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Philippa Marrack

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Amy S McKee; Michael W Munks; Matthew A Burchill; Rachel S Friedman; Jordan Jacobelli; Lei Jin; John W Kappler; Philippa Marrack
Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells.
Tomasz Sosinowski; Jason T White; Philippa Marrack; Eric W Cross; Laurent Gapin; Catherine Haluszczak; Ross M Kedl
CD8α+ dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function.
Anatoly V Rubtsov; Kira Rubtsova; John W Kappler; Philippa Marrack
TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice.

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2013: Amy S McKee; Michael W Munks; Matthew A Burchill; Rachel S Friedman; Jordan Jacobelli; Lei Jin; John W Kappler; Philippa Marrack
Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(12):E1122-31.
2013: Tomasz Sosinowski; Jason T White; Philippa Marrack; Eric W Cross; Laurent Gapin; Catherine Haluszczak; Ross M Kedl
CD8α+ dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(5):1936-47.
2013: Anatoly V Rubtsov; Kira Rubtsova; John W Kappler; Philippa Marrack
TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice.
Immunologic research 2013;55(1-3):210-6.
2013: Bernard Collins; James Hagman; Philippa Marrack; James Scott-Browne; Janice White; Eric T Clambey; John W Kappler
Ikaros promotes rearrangement of TCR α genes in an Ikaros null thymoma cell line.
European journal of immunology 2013;43(2):521-32.
2013: Megan K L Macleod; Alexandria David; Niyun Jin; John W Kappler; Laura Noges; Jieru Wang; Philippa Marrack
Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza a virus that expresses an altered nucleoprotein sequence.
PloS one 2013;8(4):e61775.
2013: Eric T Clambey; Bernard Collins; Alexandria David; Jens Eberlein; John W Kappler; Mary H Young; Philippa Marrack
The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells.
PloS one 2013;8(2):e57435.
2013: Mary H Young; Frances Crawford; Ted H Hansen; Shouxiong Huang; John Kappler; Olivier Lantz; Thierry Mallevaey; Philippa Marrack; James Scott-Browne; Lance U'Ren; Laurent Gapin
MAIT cell recognition of MR1 on bacterially infected and uninfected cells.
PloS one 2013;8(1):e53789.
2013: Lei Yin; Yang Wang; Gina Clayton; Shaodong Dai; Wei Gao; John Kappler; Philippa Marrack
Recognition of self and altered self by T cells in autoimmunity and allergy.
Protein & cell 2013;4(1):8-16.
2012: Lei Yin; Frances Crawford; John W Kappler; Philippa Marrack; Shaodong Dai
T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(45):18517-22.
2012: Lei Yin; James Scott-Browne; Laurent Gapin; John W Kappler; Philippa Marrack
T cells and their eons-old obsession with MHC.
Immunological reviews 2012;250(1):49-60.
2012: Philippa Marrack; John W Kappler
Do MHCII-presented neoantigens drive type 1 diabetes and other autoimmune diseases?
Cold Spring Harbor perspectives in medicine 2012;2(9):a007765.
2012: Romain Bedel; Manfred Brigl; John Kappler; Philippa Marrack; Jennifer L Matsuda; Janice White; Laurent Gapin
Lower TCR repertoire diversity in Traj18-deficient mice.
Nature immunology 2012;13(8):705-6.
2012: K Christopher Garcia; John W Kappler; Jarrett J Adams; Michael E Birnbaum; Laurent Gapin; James P Scott-Browne; Philippa Marrack
A closer look at TCR germline recognition.
Immunity 2012;36(6):887-8; author reply 889-90.
2012: Jennifer D Larson; Philippa Marrack; David Claypool; Anatoly V Rubtsov; Joshua M Thurman; Raul M Torres; Linda F van Dyk; Roberta Pelanda
Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(18):E1092-100.
2012: Ryan L Bjordahl; Laurent Gapin; Philippa Marrack; Yosef Refaeli
iNKT cells suppress the CD8+ T cell response to a murine Burkitt's-like B cell lymphoma.
PloS one 2012;7(8):e42635.
2011: James P Scott-Browne; Mary H Young; Frances Crawford; John W Kappler; Philippa Marrack; Laurent Gapin
Evolutionarily conserved features contribute to αβ T cell receptor specificity.
Immunity 2011;35(4):526-35.
2011: Frances Crawford; George Eisenbarth; Niyun Jin; Philippa Marrack; Aaron Michels; Maki Nakayama; Philip Pratt; Brian Stadinski; John W Kappler
Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(40):16729-34.
2011: Anatoly V Rubtsov; Kira Rubtsova; Richard T Meehan; Aryeh Fischer; Joann Z Gillis; John W Kappler; Philippa Marrack
Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c⁺ B-cell population is important for the development of autoimmunity.
Blood 2011;118(5):1305-15.
2011: Lei Yin; Frances Crawford; Shaodong Dai; Eric S Huseby; Philippa Marrack; Clamencia Pinilla; Kira Rubtsova; James Scott-Browne; John W Kappler
A single T cell receptor bound to major histocompatibility complex class I and class II glycoproteins reveals switchable TCR conformers.
Immunity 2011;35(1):23-33.
2011: Megan K L MacLeod; Amy S McKee; Alexandria David; Jieru Wang; Robert Mason; John W Kappler; Philippa Marrack
Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(19):7914-9.
2011: Thierry Mallevaey; Andrew J Clarke; James P Scott-Browne; Mary H Young; Laila C Roisman; Daniel G Pellicci; Onisha Patel; Julian P Vivian; Jennifer L Matsuda; James McCluskey; Dale I Godfrey; Philippa Marrack; Jamie Rossjohn; Laurent Gapin
A molecular basis for NKT cell recognition of CD1d-self-antigen.
Immunity 2011;34(3):315-26.
2011: Megan K L MacLeod; Alexandria David; Amy S McKee; Frances Crawford; John W Kappler; Philippa Marrack
Memory CD4 T cells that express CXCR5 provide accelerated help to B cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(5):2889-96.
2010: Michael W Munks; Amy S McKee; Megan K Macleod; Roger L Powell; Jay L Degen; Nichole A Reisdorph; John W Kappler; Philippa Marrack
Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo.
Blood 2010;116(24):5191-9.
2010: Philippa Marrack; James Scott-Browne; Megan K L MacLeod
Terminating the immune response.
Immunological reviews 2010;236():5-10.
2010: Brian D Stadinski; Li Zhang; Frances Crawford; Philippa Marrack; George S Eisenbarth; John W Kappler
Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(24):10978-83.
2010: Anatoly V Rubtsov; Kira Rubtsova; John W Kappler; Philippa Marrack
Genetic and hormonal factors in female-biased autoimmunity.
Autoimmunity reviews 2010;9(7):494-8.
2010: Brian D Stadinski; Thomas Delong; Nichole Reisdorph; Richard Reisdorph; Roger L Powell; Michael Armstrong; Jon D Piganelli; Gene Barbour; Brenda Bradley; Frances Crawford; Philippa Marrack; Sushil K Mahata; John W Kappler; Kathryn Haskins
Chromogranin A is an autoantigen in type 1 diabetes.
Nature immunology 2010;11(3):225-31.
2010: Amy S McKee; Megan K L MacLeod; John W Kappler; Philippa Marrack
Immune mechanisms of protection: can adjuvants rise to the challenge?
BMC biology 2010;8():37.
2009: Yibing Wang; Dean Becker; Tibor Vass; Janice White; Philippa Marrack; John W Kappler
A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling.
PLoS biology 2009;7(12):e1000253.
2009: Amy S McKee; Michael W Munks; Megan K L MacLeod; Courtney J Fleenor; Nico van Rooijen; John W Kappler; Philippa Marrack
Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4403-14.
2009: Adam Telerman; Robert Amson; Peter Demant; Philippa Marrack
Obituary: Jean Dausset.
Immunity 2009;31(2):171-3.
2009: Thierry Mallevaey; James P Scott-Browne; Jennifer L Matsuda; Mary H Young; Daniel G Pellicci; Onisha Patel; Meena Thakur; Lars Kjer-Nielsen; Stewart K Richardson; Vincenzo Cerundolo; Amy R Howell; James McCluskey; Dale I Godfrey; Jamie Rossjohn; Philippa Marrack; Laurent Gapin
T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire.
Immunity 2009;31(1):60-71.
2009: Kira Rubtsova; James P Scott-Browne; Frances Crawford; Shaodong Dai; Philippa Marrack; John W Kappler
Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(19):7951-6.
2009: James P Scott-Browne; Janice White; John W Kappler; Laurent Gapin; Philippa Marrack
Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection.
Nature 2009;458(7241):1043-6.
2009: Anthony L Desbien; John W Kappler; Philippa Marrack
The Epstein-Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5663-8.
2009: Megan K L MacLeod; Eric T Clambey; John W Kappler; Philippa Marrack
CD4 memory T cells: what are they and what can they do?
Seminars in immunology 2009;21(2):53-61.
2009: Philippa Marrack; Amy S McKee; Michael W Munks
Towards an understanding of the adjuvant action of aluminium.
Nature reviews. Immunology 2009;9(4):287-93.
2009: Michael F J Bassetti; Janice White; John W Kappler; Philippa Marrack
Transgenic Bcl-3 slows T cell proliferation.
International immunology 2009;21(4):339-48.
2008: Baoli Yang; Denise L Gay; Megan K L MacLeod; Xiao Cao; Tamara Hala; Eileen M Sweezer; John Kappler; Philippa Marrack; Paula M Oliver
Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells.
Nature immunology 2008;9(12):1356-63.
2008: Megan K L MacLeod; Amy McKee; Frances Crawford; Janice White; John Kappler; Philippa Marrack
CD4 memory T cells divide poorly in response to antigen because of their cytokine profile.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14521-6.
2008: Eric T Clambey; Janice White; John W Kappler; Philippa Marrack
Identification of two major types of age-associated CD8 clonal expansions with highly divergent properties.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):12997-3002.
2008: Bicheng Zhang; Jun Huang; Hong-Liang Li; Ting Liu; Yan-Yi Wang; Paul Waterman; Ai-Ping Mao; Liang-Guo Xu; Zhonghe Zhai; Depei Liu; Philippa Marrack; Hong-Bing Shu
GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth.
Cell research 2008;18(9):900-10.
2008: Shaodong Dai; Frances Crawford; Philippa Marrack; John W Kappler
The structure of HLA-DR52c: comparison to other HLA-DRB3 alleles.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11893-7.
2008: Amy S McKee; Megan MacLeod; Janice White; Frances Crawford; John W Kappler; Philippa Marrack
Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses.
International immunology 2008;20(5):659-69.
2008: Philippa Marrack; Kira Rubtsova; James Scott-Browne; John W Kappler
T cell receptor specificity for major histocompatibility complex proteins.
Current opinion in immunology 2008;20(2):203-7.
2008: Shaodong Dai; Eric S Huseby; Kira Rubtsova; James Scott-Browne; Frances Crawford; Whitney A Macdonald; Philippa Marrack; John W Kappler
Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules.
Immunity 2008;28(3):324-34.
2008: Eric S Huseby; John W Kappler; Philippa Marrack
Thymic selection stifles TCR reactivity with the main chain structure of MHC and forces interactions with the peptide side chains.
Molecular immunology 2008;45(3):599-606.
2008: Philippa Marrack; James P Scott-Browne; Shaodong Dai; Laurent Gapin; John W Kappler
Evolutionarily conserved amino acids that control TCR-MHC interaction.
Annual review of immunology 2008;26():171-203.
2007: Trine N Jørgensen; E Roper; Joshua M Thurman; Philippa Marrack; Brian L Kotzin
Type I interferon signaling is involved in the spontaneous development of lupus-like disease in B6.Nba2 and (B6.Nba2 x NZW)F(1) mice.
Genes and immunity 2007;8(8):653-62.
2007: Amy S McKee; Michael W Munks; Philippa Marrack
How do adjuvants work? Important considerations for new generation adjuvants.
Immunity 2007;27(5):687-90.
2007: James P Scott-Browne; Jennifer L Matsuda; Thierry Mallevaey; Janice White; Natalie A Borg; James McCluskey; Jamie Rossjohn; John Kappler; Philippa Marrack; Laurent Gapin
Germline-encoded recognition of diverse glycolipids by natural killer T cells.
Nature immunology 2007;8(10):1105-13.
2007: David A Hildeman; Trine Jorgensen; John Kappler; Philippa Marrack
Apoptosis and the homeostatic control of immune responses.
Current opinion in immunology 2007;19(5):516-21.
2007: Trine N Jorgensen; Amy McKee; Michael Wang; Ella Kushnir; Janice White; Yosef Refaeli; John W Kappler; Philippa Marrack
Bim and Bcl-2 mutually affect the expression of the other in T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):3417-24.
2007: Philippa Marrack
Conference summary.
Proceedings of the American Thoracic Society 2007;4(5):469-71.
2007: Khie Khiong; Masaaki Murakami; Chika Kitabayashi; Naoko Ueda; Shin-ichiro Sawa; Akemi Sakamoto; Brian L Kotzin; Stephen Rozzo; Katsuhiko Ishihara; Marileila Verella-Garcia; John Kappler; Philippa Marrack; Toshio Hirano
Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model.
The Journal of clinical investigation 2007;117(5):1270-81.
2007: Eric T Clambey; John W Kappler; Philippa Marrack
CD8 T cell clonal expansions & aging: a heterogeneous phenomenon with a common outcome.
Experimental gerontology 2007;42(5):407-11.
2007: Fred W Peyerl; Shaodong Dai; G A Murphy; F Crawford; J White; Philippa Marrack; John W Kappler
Elucidation of some Bax conformational changes through crystallization of an antibody-peptide complex.
Cell death and differentiation 2007;14(3):447-52.
2006: Xinqi Liu; Yanan Zhu; Shaodong Dai; Janice White; Fred W Peyerl; John W Kappler; Philippa Marrack
Bcl-xl does not have to bind Bax to protect T cells from death.
The Journal of experimental medicine 2006;203(13):2953-61.
2006: Paula M Oliver; Xiao Cao; George Scott Worthen; Peijun Shi; Natalie Briones; Megan MacLeod; Janice White; Patricia Kirby; John Kappler; Philippa Marrack; Baoli Yang
Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation.
Immunity 2006;25(6):929-40.
2006: Eric S Huseby; Frances Crawford; Janice White; Philippa Marrack; John W Kappler
Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide.
Nature immunology 2006;7(11):1191-9.
2006: Trine N Jørgensen; Joshua M Thurman; Shozo Izui; Michael T Falta; Troy E Metzger; S A Flannery; John Kappler; Philippa Marrack; Brian L Kotzin
Genetic susceptibility to polyI:C-induced IFNalpha/beta-dependent accelerated disease in lupus-prone mice.
Genes and immunity 2006;7(7):555-67.
2006: Richard A Willis; John W Kappler; Philippa Marrack
CD8 T cell competition for dendritic cells in vivo is an early event in activation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(32):12063-8.
2006: Jennifer M Robertson; Megan MacLeod; Vanessa S Marsden; John W Kappler; Philippa Marrack
Not all CD4+ memory T cells are long lived.
Immunological reviews 2006;211():49-57.
2006: Yanan Zhu; Xinqi Liu; David A Hildeman; Fred W Peyerl; Janice White; Ella Kushnir; John Kappler; Philippa Marrack
Bax does not have to adopt its final form to drive T cell death.
The Journal of experimental medicine 2006;203(5):1147-52.
2006: Philippa Marrack
Thymocytes and bone marrow cells in 1966: where did we go from there?
The Journal of allergy and clinical immunology 2006;117(4):962-4.
2006: Frances Crawford; Kimberly R Jordan; Brian Stadinski; Yibing Wang; Eric S Huseby; Philippa Marrack; Jill E Slansky; John W Kappler
Use of baculovirus MHC/peptide display libraries to characterize T-cell receptor ligands.
Immunological reviews 2006;210():156-70.
2006: Paula M Oliver; Tibor Vass; John Kappler; Philippa Marrack
Loss of the proapoptotic protein, Bim, breaks B cell anergy.
The Journal of experimental medicine 2006;203(3):731-41.
2006: John Kappler; Ralph Kubo; Kathryn Haskins; Charles Hannum; Philippa Marrack; Michele Pigeon; Bradley McIntyre; James Allison; Ian Trowbridge
The major histocompatibility complex-restricted antigen receptor on T cells in mouse and man: identification of constant and variable peptides. 1983.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):2683-90.
2006: Vanessa S Marsden; John W Kappler; Philippa Marrack
Homeostasis of the memory T cell pool.
International archives of allergy and immunology 2006;139(1):63-74.
2005: Eric T Boder; Jerome R Bill; Andrew W Nields; Philippa Marrack; John W Kappler
Yeast surface display of a noncovalent MHC class II heterodimer complexed with antigenic peptide.
Biotechnology and bioengineering 2005;92(4):485-91.
2005: Eric S Huseby; Janice White; Frances Crawford; Tibor Vass; Dean Becker; Clemencia Pinilla; Philippa Marrack; John W Kappler
How the T cell repertoire becomes peptide and MHC specific.
Cell 2005;122(2):247-60.
2005: Michael T Falta; Andrew P Fontenot; Edward F Rosloniec; Frances Crawford; Christina L Roark; Jerome R Bill; Philippa Marrack; John Kappler; Brian L Kotzin
Class II major histocompatibility complex-peptide tetramer staining in relation to functional avidity and T cell receptor diversity in the mouse CD4(+) T cell response to a rheumatoid arthritis-associated antigen.
Arthritis and rheumatism 2005;52(6):1885-96.
2005: Eric T Clambey; Linda F van Dyk; John W Kappler; Philippa Marrack
Non-malignant clonal expansions of CD8+ memory T cells in aged individuals.
Immunological reviews 2005;205():170-89.
2005: Yibing Wang; Anatoyla Rubtsov; Ryan Heiser; Janice White; Frances Crawford; Philippa Marrack; John W Kappler
Using a baculovirus display library to identify MHC class I mimotopes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2476-81.
2005: Peter R Hoffmann; Jennifer Kench; Andrea Vondracek; Ellen Kruk; David L Daleke; Michael Jordan; Philippa Marrack; Peter M Henson; Valerie A Fadok
Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1393-404.
2004: Paula M Oliver; Michael Wang; Yanan Zhu; Janice White; John Kappler; Philippa Marrack
Loss of Bim allows precursor B cell survival but not precursor B cell differentiation in the absence of interleukin 7.
The Journal of experimental medicine 2004;200(9):1179-87.
2004: Michael B Jordan; David A Hildeman; John Kappler; Philippa Marrack
An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder.
Blood 2004;104(3):735-43.
2004: Michael B Jordan; David M Mills; John Kappler; Philippa Marrack; John C Cambier
Promotion of B cell immune responses via an alum-induced myeloid cell population.
Science (New York, N.Y.) 2004;304(5678):1808-10.
2004: Yanan Zhu; Bradley J Swanson; Michael Wang; David A Hildeman; Brian C Schaefer; Xinqi Liu; Hiroyuki Suzuki; Katsuyoshi Mihara; John Kappler; Philippa Marrack
Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(20):7681-6.
2004: Shyra J Gardai; David A Hildeman; Steve K Frankel; Ben B Whitlock; S Courtney Frasch; Niels Borregaard; Philippa Marrack; Donna L Bratton; Peter M Henson
Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils.
The Journal of biological chemistry 2004;279(20):21085-95.
2004: Eric S Huseby; John Kappler; Philippa Marrack
TCR-MHC/peptide interactions: kissing-cousins or a shotgun wedding?
European journal of immunology 2004;34(5):1243-50.
2004: Frances Crawford; Eric S Huseby; Janice White; Philippa Marrack; John W Kappler
Mimotopes for alloreactive and conventional T cells in a peptide-MHC display library.
PLoS biology 2004;2(4):E90.
2004: Brian C Schaefer; John W Kappler; Abraham Kupfer; Philippa Marrack
Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(4):1004-9.
2004: Philippa Marrack; John Kappler
Control of T cell viability.
Annual review of immunology 2004;22():765-87.
2003: David A Hildeman; Thomas Mitchell; Bruce Aronow; Sara Wojciechowski; John Kappler; Philippa Marrack
Control of Bcl-2 expression by reactive oxygen species.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15035-40.
2003: Vanessa L Ott; John C Cambier; John Kappler; Philippa Marrack; Bradley J Swanson
Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4.
Nature immunology 2003;4(10):974-81.
2003: Eric S Huseby; Frances Crawford; Janice White; John Kappler; Philippa Marrack
Negative selection imparts peptide specificity to the mature T cell repertoire.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11565-70.
2003: Xinqi Liu; Shaodong Dai; Yanan Zhu; Philippa Marrack; John W Kappler
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function.
Immunity 2003;19(3):341-52.
2003: Linh Lu; Jörg Vollmer; Corinne Moulon; Hans Ulrich Weltzien; Philippa Marrack; John Kappler
Components of the ligand for a Ni++ reactive human T cell clone.
The Journal of experimental medicine 2003;197(5):567-74.
2003: David A Hildeman; Thomas Mitchell; John Kappler; Philippa Marrack
T cell apoptosis and reactive oxygen species.
The Journal of clinical investigation 2003;111(5):575-81.
2003: Ross M Kedl; John W Kappler; Philippa Marrack
Epitope dominance, competition and T cell affinity maturation.
Current opinion in immunology 2003;15(1):120-7.
2003: Michael B Jordan; Nico van Rooijen; Shozo Izui; John Kappler; Philippa Marrack
Liposomal clodronate as a novel agent for treating autoimmune hemolytic anemia in a mouse model.
Blood 2003;101(2):594-601.
2002: Thomas C Mitchell; Teague Kent; David A Hildeman; Jeremy Bender; William A Rees; Ross M Kedl; Brad Swanson; John W Kappler; Philippa Marrack
Stronger correlation of bcl-3 than bcl-2, bcl-xL, costimulation, or antioxidants with adjuvant-induced T cell survival.
Annals of the New York Academy of Sciences 2002;975():114-31.
2002: Bradley J Swanson; Masaaki Murakami; Thomas C Mitchell; John Kappler; Philippa Marrack
RANTES production by memory phenotype T cells is controlled by a posttranscriptional, TCR-dependent process.
Immunity 2002;17(5):605-15.
2002: Masaaki Murakami; Akemi Sakamoto; Jeremy Bender; John Kappler; Philippa Marrack
CD25+CD4+ T cells contribute to the control of memory CD8+ T cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8832-7.
2002: Xinqi Liu; Shaodong Dai; Frances Crawford; Rachel Fruge; Philippa Marrack; John Kappler
Alternate interactions define the binding of peptides to the MHC molecule IA(b).
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8820-5.
2002: David A Hildeman; Yanan Zhu; Thomas C Mitchell; Philippe Bouillet; Andreas Strasser; John Kappler; Philippa Marrack
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.
Immunity 2002;16(6):759-67.
2002: David A Hildeman; Yanan Zhu; Thomas C Mitchell; John Kappler; Philippa Marrack
Molecular mechanisms of activated T cell death in vivo.
Current opinion in immunology 2002;14(3):354-9.
2002: daved fremont; Shaodong Dai; Herbert Chiang; Frances Crawford; Philippa Marrack; John Kappler
Structural basis of cytochrome c presentation by IE(k).
The Journal of experimental medicine 2002;195(8):1043-52.
2002: Angela Rico de Souza; Bradley Swanson; Jennifer Robertson; Jeremy Bender; John Kappler; Philippa Marrack
Some properties of T cells in animals.
Advances in experimental medicine and biology 2002;512():121-8.
2002: Lone M Veng; Kimberly B Bjugstad; Curt R Freed; Philippa Marrack; Edward D Clarkson; K Patricia Bell; Cindy Hutt; W Michael Zawada
Xenografts of MHC-deficient mouse embryonic mesencephalon improve behavioral recovery in hemiparkinsonian rats.
Cell transplantation 2002;11(1):5-16.
2002: Ross M Kedl; Brian C Schaefer; John W Kappler; Philippa Marrack
T cells down-modulate peptide-MHC complexes on APCs in vivo.
Nature immunology 2002;3(1):27-32.
2001: Brian C Schaefer; M L Schaefer; John W Kappler; Philippa Marrack; Ross M Kedl
Observation of antigen-dependent CD8+ T-cell/ dendritic cell interactions in vivo.
Cellular immunology 2001;214(2):110-22.
2001: Brian C Schaefer; Thomas C Mitchell; John W Kappler; Philippa Marrack
A novel family of retroviral vectors for the rapid production of complex stable cell lines.
Analytical biochemistry 2001;297(1):86-93.
2001: Ross M Kedl; M Jordan; TA Potter; John Kappler; Philippa Marrack; Steven W Dow
CD40 stimulation accelerates deletion of tumor-specific CD8(+) T cells in the absence of tumor-antigen vaccination.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10811-6.
2001: Philippa Marrack; Jeremy Bender; Michael Jordan; WA Rees; J Robertson; Brian C Schaefer; John Kappler
Major histocompatibility complex proteins and TCRs: do they really go together like a horse and carriage?
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):617-21.
2001: N Wilson; daved fremont; Philippa Marrack; John Kappler
Mutations changing the kinetics of class II MHC peptide exchange.
Immunity 2001;14(5):513-22.
2001: Thomas C Mitchell; David A Hildeman; Ross M Kedl; Teague Kent; Brian C Schaefer; J White; Yanan Zhu; John Kappler; Philippa Marrack
Immunological adjuvants promote activated T cell survival via induction of Bcl-3.
Nature immunology 2001;2(5):397-402.
2001: CC Ku; John Kappler; Philippa Marrack
The growth of the very large CD8+ T cell clones in older mice is controlled by cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2186-93.
2000: Ross M Kedl; WA Rees; David A Hildeman; Brian C Schaefer; T Mitchell; John Kappler; Philippa Marrack
T cells compete for access to antigen-bearing antigen-presenting cells.
The Journal of experimental medicine 2000;192(8):1105-13.
2000: Philippa Marrack; Jeremy Bender; David A Hildeman; Michael Jordan; T Mitchell; M Murakami; A Sakamoto; Brian C Schaefer; B Swanson; John Kappler
Homeostasis of alpha beta TCR+ T cells.
Nature immunology 2000;1(2):107-11.
2000: CC Ku; M Murakami; A Sakamoto; John Kappler; Philippa Marrack
Control of homeostasis of CD8+ memory T cells by opposing cytokines.
Science (New York, N.Y.) 2000;288(5466):675-8.
2000: Philippa Marrack; T Mitchell; David A Hildeman; Ross M Kedl; Teague Kent; J Bender; W Rees; B C Schaefer; John Kappler
Genomic-scale analysis of gene expression in resting and activated T cells.
Current opinion in immunology 2000;12(2):206-9.
2000: Teague Kent; Brian C Schaefer; David A Hildeman; Jeremy Bender; T Mitchell; John W Kappler; Philippa Marrack
Activation-induced inhibition of interleukin 6-mediated T cell survival and signal transducer and activator of transcription 1 signaling.
The Journal of experimental medicine 2000;191(6):915-26.
2000: Brian L Kotzin; Michael T Falta; F Crawford; Edward F Rosloniec; Jerome R Bill; Philippa Marrack; John Kappler
Use of soluble peptide-DR4 tetramers to detect synovial T cells specific for cartilage antigens in patients with rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):291-6.
1999: Teague Kent; David A Hildeman; Ross M Kedl; T Mitchell; WA Rees; Brian C Schaefer; Jeremy Bender; John Kappler; Philippa Marrack
Activation changes the spectrum but not the diversity of genes expressed by T cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12691-6.
1999: Brian C Schaefer; Marti Ware; Philippa Marrack; Gary R Fanger; John W Kappler; Gary L Johnson; CR Monks
Live cell fluorescence imaging of T cell MEKK2: redistribution and activation in response to antigen stimulation of the T cell receptor.
Immunity 1999;11(4):411-21.
1999: WA Rees; Jeremy Bender; Teague Kent; Ross M Kedl; Frances Crawford; Philippa Marrack; John Kappler
An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9781-6.
1999: Jeremy Bender; T Mitchell; John Kappler; Philippa Marrack
CD4+ T cell division in irradiated mice requires peptides distinct from those responsible for thymic selection.
The Journal of experimental medicine 1999;190(3):367-74.
1999: David A Hildeman; T Mitchell; Teague Kent; Peter M Henson; Brian Day; John Kappler; Philippa Marrack
Reactive oxygen species regulate activation-induced T cell apoptosis.
Immunity 1999;10(6):735-44.
1999: T Mitchell; John Kappler; Philippa Marrack
Bystander virus infection prolongs activated T cell survival.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4527-35.
1999: Janice White; Frances Crawford; daved fremont; Philippa Marrack; John Kappler
Soluble class I MHC with beta2-microglobulin covalently linked peptides: specific binding to a T cell hybridoma.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2671-6.
1999: Philippa Marrack; John Kappler; T Mitchell
Type I interferons keep activated T cells alive.
The Journal of experimental medicine 1999;189(3):521-30.
1998: N A Wilson; P Wolf; H Ploegh; Leszek Ignatowicz; John Kappler; Philippa Marrack
Invariant chain can bind MHC class II at a site other than the peptide binding groove.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4777-84.
1998: Philippa Marrack; T Mitchell; J Bender; David A Hildeman; Ross M Kedl; Teague Kent; John Kappler
T-cell survival.
Immunological reviews 1998;165():279-85.
1998: daved fremont; F Crawford; Philippa Marrack; Wayne A Hendrickson; John Kappler
Crystal structure of mouse H2-M.
Immunity 1998;9(3):385-93.
1998: Frances Crawford; H Kozono; Janice White; Philippa Marrack; John Kappler
Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes.
Immunity 1998;8(6):675-82.
1998: C P Liu; Frances Crawford; Philippa Marrack; John Kappler
T cell positive selection by a high density, low affinity ligand.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4522-6.
1998: Anthony T Vella; Steven W Dow; TA Potter; John Kappler; Philippa Marrack
Cytokine-induced survival of activated T cells in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3810-5.
1997: CC Ku; B Kotzin; John Kappler; Philippa Marrack
CD8+ T-cell clones in old mice.
Immunological reviews 1997;160():139-44.
1997: C P Liu; David Parker; John Kappler; Philippa Marrack
Selection of antigen-specific T cells by a single IEk peptide combination.
The Journal of experimental medicine 1997;186(9):1441-50.
1997: Leszek Ignatowicz; W Rees; Rafal Pacholczyk; Hanna Ignatowicz; Ella Kushnir; John Kappler; Philippa Marrack
T cells can be activated by peptides that are unrelated in sequence to their selecting peptide.
Immunity 1997;7(2):179-86.
1997: A Vella; Teague Kent; James N Ihle; John Kappler; Philippa Marrack
Interleukin 4 (IL-4) or IL-7 prevents the death of resting T cells: stat6 is probably not required for the effect of IL-4.
The Journal of experimental medicine 1997;186(2):325-30.
1997: Teague Kent; Philippa Marrack; John W Kappler; AT Vella
IL-6 rescues resting mouse T cells from apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5791-6.
1997: J L Seibel; N Wilson; H Kozono; Philippa Marrack; John W Kappler
Influence of the NH2-terminal amino acid of the T cell receptor alpha chain on major histocompatibility complex (MHC) class II + peptide recognition.
The Journal of experimental medicine 1997;185(11):1919-27.
1997: AT Vella; T Mitchell; B Groth; Peter Linsley; J M Green; Craig Thompson; John W Kappler; Philippa Marrack
CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4714-20.
1997: Abdel Rahim A Hamad; Philippa Marrack; John W Kappler
Transcytosis of staphylococcal superantigen toxins.
The Journal of experimental medicine 1997;185(8):1447-54.
1997: Philippa Marrack; John Kappler
Positive selection of thymocytes bearing alpha beta T cell receptors.
Current opinion in immunology 1997;9(2):250-5.
1997: CC Ku; John Kappler; Philippa Marrack
Characteristics and maintenance of CD8+ T-cell clones found in old mice.
Mechanisms of ageing and development 1997;94(1-3):41-53.
1997: Eckard H Hamelmann; AT Vella; A Oshiba; John W Kappler; Philippa Marrack; Erwin W Gelfand
Allergic airway sensitization induces T cell activation but not airway hyperresponsiveness in B cell-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1350-5.
1997: C P Liu; W J Lin; M Huang; John W Kappler; Philippa Marrack
Development and function of T cells in T cell antigen receptor/CD3 zeta knockout mice reconstituted with Fc epsilon RI gamma.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):616-21.
1996: C P Liu; John W Kappler; Philippa Marrack
Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage.
The Journal of experimental medicine 1996;184(5):1619-30.
1996: Leszek Ignatowicz; John Kappler; David Parker; Philippa Marrack
The responses of mature T cells are not necessarily antagonized by their positively selecting peptide.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(5):1827-31.
1996: daved fremont; Wayne A Hendrickson; Philippa Marrack; John Kappler
Structures of an MHC class II molecule with covalently bound single peptides.
Science (New York, N.Y.) 1996;272(5264):1001-4.
1996: Leszek Ignatowicz; J Kappler; Philippa Marrack
The repertoire of T cells shaped by a single MHC/peptide ligand.
Cell 1996;84(4):521-9.
1996: AT Vella; M T Scherer; L Schultz; John W Kappler; Philippa Marrack
B cells are not essential for peripheral T-cell tolerance.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(2):951-5.
1995: M T Scherer; Leszek Ignatowicz; A Pullen; John Kappler; Philippa Marrack
The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire.
The Journal of experimental medicine 1995;182(5):1493-504.
1995: Leszek Ignatowicz; G Winslow; J Bill; John Kappler; Philippa Marrack
Cell surface expression of class II MHC proteins bound by a single peptide.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(8):3852-62.
1995: AT Vella; J E McCormack; Peter Linsley; John W Kappler; Philippa Marrack
Lipopolysaccharide interferes with the induction of peripheral T cell death.
Immunity 1995;2(3):261-70.
1994: John Kappler; J White; H Kozono; J Clements; Philippa Marrack
Binding of a soluble alpha beta T-cell receptor to superantigen/major histocompatibility complex ligands.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(18):8462-6.
1994: Abdel Rahim A Hamad; A Herman; Philippa Marrack; John W Kappler
Monoclonal antibodies defining functional sites on the toxin superantigen staphylococcal enterotoxin B.
The Journal of experimental medicine 1994;180(2):615-21.
1994: H Kozono; J White; J Clements; Philippa Marrack; John Kappler
Production of soluble MHC class II proteins with covalently bound single peptides.
Nature 1994;369(6476):151-4.
1994: J P Donahue; N S Ricalton; C E Behrendt; C Rittershaus; S Calaman; Philippa Marrack; John W Kappler; Brian L Kotzin
Genetic analysis of low V beta 3 expression in humans.
The Journal of experimental medicine 1994;179(5):1701-6.
1994: G M Winslow; Philippa Marrack; John W Kappler
Processing and major histocompatibility complex binding of the MTV7 superantigen.
Immunity 1994;1(1):23-33.
1994: J E McCormack; J Kappler; Philippa Marrack
Stimulation with specific antigen can block superantigen-mediated deletion of T cells in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):2086-90.
1994: P Hugo; John W Kappler; Dale I Godfrey; Philippa Marrack
Thymic epithelial cell lines that mediate positive selection can also induce thymocyte clonal deletion.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(3):1022-31.
1994: Philippa Marrack; John Kappler
Subversion of the immune system by pathogens.
Cell 1994;76(2):323-32.
1994: Leszek Ignatowicz; John W Kappler; Philippa Marrack; M T Scherer
Identification of two V beta 7-specific viral superantigens.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(1):65-71.
1993: J E Callahan; John W Kappler; Philippa Marrack
Unexpected expansions of CD8-bearing cells in old mice.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(12):6657-69.
1993: Philippa Marrack; Leszek Ignatowicz; John W Kappler; J Boymel; J H Freed
Comparison of peptides bound to spleen and thymus class II.
The Journal of experimental medicine 1993;178(6):2173-83.
1993: P Hugo; John W Kappler; J E McCormack; Philippa Marrack
Fibroblasts can induce thymocyte positive selection in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):10335-9.
1993: P Hugo; John W Kappler; Philippa Marrack
Positive selection of TcR alpha beta thymocytes: is cortical thymic epithelium an obligatory participant in the presentation of major histocompatibility complex protein?
Immunological reviews 1993;135():133-55.
1993: Philippa Marrack; G M Winslow; Y Choi; M Scherer; A Pullen; J White; John W Kappler
The bacterial and mouse mammary tumor virus superantigens; two different families of proteins with the same functions.
Immunological reviews 1993;131():79-92.
1993: J White; A Pullen; K Choi; Philippa Marrack; John W Kappler
Antigen recognition properties of mutant V beta 3+ T cell receptors are consistent with an immunoglobulin-like structure for the receptor.
The Journal of experimental medicine 1993;177(1):119-25.
1993: Philippa Marrack
T cell tolerance.
Harvey lectures 1993;89():147-55.
1993: M T Scherer; Leszek Ignatowicz; G M Winslow; John W Kappler; Philippa Marrack
Superantigens: bacterial and viral proteins that manipulate the immune system.
Annual review of cell biology 1993;9():101-28.
1992: P Hugo; John W Kappler; Dale I Godfrey; Philippa Marrack
A cell line that can induce thymocyte positive selection.
Nature 1992;360(6405):679-82.
1992: G M Winslow; M T Scherer; John W Kappler; Philippa Marrack
Detection and biochemical characterization of the mouse mammary tumor virus 7 superantigen (Mls-1a).
Cell 1992;71(5):719-30.
1992: Leszek Ignatowicz; John Kappler; Philippa Marrack
The effects of chronic infection with a superantigen-producing virus.
The Journal of experimental medicine 1992;175(4):917-23.
1992: Y Choi; Philippa Marrack; John W Kappler
Structural analysis of a mouse mammary tumor virus superantigen.
The Journal of experimental medicine 1992;175(3):847-52.
1992: John W Kappler; A Herman; J Clements; Philippa Marrack
Mutations defining functional regions of the superantigen staphylococcal enterotoxin B.
The Journal of experimental medicine 1992;175(2):387-96.
1991: J E McCormack; T Wade; H Morales; John Kappler; Philippa Marrack
Analysis of class II MHC structure in thymic nurse cells.
Cellular immunology 1991;138(2):413-22.
1991: A Herman; N Labrecque; Jacques Thibodeau; Philippa Marrack; John W Kappler; Rafick-Pierre Sekaly
Identification of the staphylococcal enterotoxin A superantigen binding site in the beta 1 domain of the human histocompatibility antigen HLA-DR.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(22):9954-8.
1991: Y Choi; John W Kappler; Philippa Marrack
A superantigen encoded in the open reading frame of the 3' long terminal repeat of mouse mammary tumour virus.
Nature 1991;350(6315):203-7.
1991: Philippa Marrack; E Kushnir; John Kappler
A maternally inherited superantigen encoded by a mammary tumour virus.
Nature 1991;349(6309):524-6.
1991: J E McCormack; John Kappler; Philippa Marrack; J Y Westcott
Production of prostaglandin E2 and prostacyclin by thymic nurse cells in culture.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(1):239-43.
1991: A Herman; John W Kappler; Philippa Marrack; A M Pullen
Superantigens: mechanism of T-cell stimulation and role in immune responses.
Annual review of immunology 1991;9():745-72.
1990: A Herman; G Croteau; Rafick-Pierre Sekaly; John Kappler; Philippa Marrack
HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells.
The Journal of experimental medicine 1990;172(3):709-17.
1990: A M Pullen; T Wade; Philippa Marrack; John W Kappler
Identification of the region of T cell receptor beta chain that interacts with the self-superantigen MIs-1a.
Cell 1990;61(7):1365-74.
1990: Philippa Marrack; John Kappler
The staphylococcal enterotoxins and their relatives.
Science (New York, N.Y.) 1990;248(4956):705-11.
1990: J E Callahan; A Herman; John W Kappler; Philippa Marrack
Stimulation of B10.BR T cells with superantigenic staphylococcal toxins.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(7):2473-9.
1990: Philippa Marrack; M Blackman; E Kushnir; John Kappler
The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells.
The Journal of experimental medicine 1990;171(2):455-64.
1990: W T Golde; M McDuffie; John Kappler; Philippa Marrack
Identification of a new cell surface glycoprotein with accessory function in murine T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(3):804-10.
1990: A M Pullen; W Potts; E K Wakeland; John Kappler; Philippa Marrack
Surprisingly uneven distribution of the T cell receptor V beta repertoire in wild mice.
The Journal of experimental medicine 1990;171(1):49-62.
1989: H G Burgert; J White; H U Weltzien; Philippa Marrack; John W Kappler
Reactivity of V beta 17a+ CD8+ T cell hybrids. Analysis using a new CD8+ T cell fusion partner.
The Journal of experimental medicine 1989;170(6):1887-904.
1989: Y W Choi; B Kotzin; L Herron; J Callahan; Philippa Marrack; John Kappler
Interaction of Staphylococcus aureus toxin "superantigens" with human T cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):8941-5.
1989: J White; M Blackman; J Bill; John Kappler; Philippa Marrack; D P Gold; W Born
Two better cell lines for making hybridomas expressing specific T cell receptors.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(6):1822-5.
1989: John W Kappler; E Kushnir; Philippa Marrack
Analysis of V beta 17a expression in new mouse strains bearing the V beta a haplotype.
The Journal of experimental medicine 1989;169(5):1533-41.
1989: A M Pullen; Philippa Marrack; John W Kappler
Evidence that Mls-2 antigens which delete V beta 3+ T cells are controlled by multiple genes.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(9):3033-7.
1989: R T Kubo; Willi K Born; John W Kappler; Philippa Marrack; M Pigeon
Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(8):2736-42.
1989: Philippa Marrack; J McCormack; John Kappler
Presentation of antigen, foreign major histocompatibility complex proteins and self by thymus cortical epithelium.
Nature 1989;338(6215):503-5.
1989: A M Pullen; J W Kappler; Philippa Marrack
Tolerance to self antigens shapes the T-cell repertoire.
Immunological reviews 1989;107():125-39.
1989: J White; A Herman; A M Pullen; R Kubo; John W Kappler; Philippa Marrack
The V beta-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice.
Cell 1989;56(1):27-35.
1989: John W Kappler; A Pullen; J Callahan; Y Choi; A Herman; J White; W Potts; E Wakeland; Philippa Marrack
Consequences of self and foreign superantigen interaction with specific V beta elements of the murine TCR alpha beta.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():401-7.
1988: J Yague; M Blackman; Willi K Born; Philippa Marrack; J Kappler; E Palmer
The structure of V alpha and J alpha segments in the mouse.
Nucleic acids research 1988;16(23):11355-64.
1988: A M Carbone; Philippa Marrack; John W Kappler
Demethylated CD8 gene in CD4+ T cells suggests that CD4+ cells develop from CD8+ precursors.
Science (New York, N.Y.) 1988;242(4882):1174-6.
1988: M McDuffie; N Roehm; John W Kappler; Philippa Marrack
Involvement of major histocompatibility complex products in tolerance induction in the thymus.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(6):1840-7.
1988: T Wade; J Bill; Philippa Marrack; E Palmer; John W Kappler
Molecular basis for the nonexpression of V beta 17 in some strains of mice.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(6):2165-7.
1988: A M Carbone; Philippa Marrack; John W Kappler
Remethylation at sites 5' of the murine Lyt-2 gene in association with shutdown of Lyt-2 expression.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(4):1369-75.
1988: D Gay; Soren Buus; J Pasternak; J Kappler; Philippa Marrack
The T-cell accessory molecule CD4 recognizes a monomorphic determinant on isolated Ia.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(15):5629-33.
1988: Philippa Marrack; D Lo; R Brinster; R Palmiter; L Burkly; R H Flavell; John Kappler
The effect of thymus environment on T cell development and tolerance.
Cell 1988;53(4):627-34.
1988: Willi K Born; J White; John Kappler; Philippa Marrack
Rearrangement of IgH genes in normal thymocyte development.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(9):3228-32.
1988: Philippa Marrack; E Kushnir; W Born; M McDuffie; John Kappler
The development of helper T cell precursors in mouse thymus.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(8):2508-14.
1988: M A Blackman; John W Kappler; Philippa Marrack
T-cell specificity and repertoire.
Immunological reviews 1988;101():5-19.
1987: M McDuffie; N Roehm; W Born; Philippa Marrack; John W Kappler
T cell receptor/MHC interactions in the thymus and the shaping of the T cell repertoire.
Transplantation proceedings 1987;19(6 Suppl 7):111-6.
1987: Philippa Marrack; John Kappler
The T cell receptor.
Science (New York, N.Y.) 1987;238(4830):1073-9.
1987: T H Finkel; M McDuffie; John W Kappler; Philippa Marrack; J C Cambier
Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking.
Nature 1987;330(6144):179-81.
1987: John W Kappler; N Roehm; Philippa Marrack
T cell tolerance by clonal elimination in the thymus.
Cell 1987;49(2):273-80.
1987: John W Kappler; T Wade; J White; E Kushnir; M Blackman; J Bill; N Roehm; Philippa Marrack
A T cell receptor V beta segment that imparts reactivity to a class II major histocompatibility complex product.
Cell 1987;49(2):263-71.
1987: W Born; M McDuffie; N Roehm; E Kushnir; J White; D Thorpe; J Stefano; John Kappler; Philippa Marrack
Expression and role of the T cell receptor in early thymocyte differentiation in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(4):999-1008.
1985: N W Roehm; A Carbone; E Kushnir; B A Taylor; R J Riblet; Philippa Marrack; John W Kappler
The major histocompatibility complex-restricted antigen receptor on T cells: the genetics of expression of an allotype.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(3):2176-82.
1984: N W Roehm; H J Leibson; Albert Zlotnik; John Kappler; Philippa Marrack; J C Cambier
Interleukin-induced increase in Ia expression by normal mouse B cells.
The Journal of experimental medicine 1984;160(3):679-94.
1984: H J Leibson; M Gefter; Albert Zlotnik; Philippa Marrack; John W Kappler
Role of gamma-interferon in antibody-producing responses.
Nature 1984;309(5971):799-801.
1983: Albert Zlotnik; W K Roberts; A Vasil; E Blumenthal; F Larosa; H J Leibson; R O Endres; S D Graham; J White; J Hill; P Henson; J R Klein; M J Bevan; Philippa Marrack; John W Kappler
Coordinate production by a T cell hybridoma of gamma interferon and three other lymphokine activities: multiple activities of a single lymphokine?
Journal of immunology (Baltimore, Md. : 1950) 1983;131(2):794-800.
1983: N W Roehm; Philippa Marrack; John W Kappler
Helper signals in the plaque-forming cell response to protein-bound haptens.
The Journal of experimental medicine 1983;158(2):317-33.
1983: R O Endres; E Kushnir; John W Kappler; Philippa Marrack; S C Kinsky
A requirement for nonspecific T cell factors in antibody responses to "T cell independent" antigens.
Journal of immunology (Baltimore, Md. : 1950) 1983;130(2):781-4.
1982: N W Roehm; Philippa Marrack; John W Kappler
Antigen-specific, H-2-restricted helper T cell hybridomas.
The Journal of experimental medicine 1982;156(1):191-204.
1982: Philippa Marrack; S D Graham; E Kushnir; H J Leibson; N Roehm; John W Kappler
Nonspecific factors in B cell responses.
Immunological reviews 1982;63():33-49.
1982: R O Endres; E Kushnir; John W Kappler; Philippa Marrack; S C Kinsky
A role for T cell helper factors in antibody responses to "T-independent" antigens.
Lymphokine research 1982;1(4):99-106.
1981: H J Leibson; Philippa Marrack; John W Kappler
B cell helper factors. I. Requirement for both interleukin 2 and another 40,000 mol wt factor.
The Journal of experimental medicine 1981;154(5):1681-93.