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Lawrence Marsh

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Estelle Sontag; Andrew Tran; Guocheng Yang; Namita Agrawal; Rebecca Aron; Steven Finkbeiner; Charles G Glabe; Alice Lau; Gregor P Lotz; J Lawrence Marsh; Paul J Muchowski; Mihaela Necula; Leslie M Thompson
Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models.
Haiqun Jia; Alice Lau; J Lawrence Marsh; Judit Pallos; Heather Plasterer; Judith Purcell; James R Rusche; Ghazaleh Sadri-Vakili; Gavin R Sangrey; Shefali Sharma; Adeela Syed; Bin Tang; Yi Chen; Andrew Cooper; Shayna B Darnell; Joel M Gottesfeld; Vincent Jacques; Leslie M Thompson; Elizabeth A Thomas
Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease.
Laszlo Bodai; Judit Pallos; Leslie Michels Thompson; J Lawrence Marsh
Pcaf modulates polyglutamine pathology in a Drosophila model of Huntington's disease.

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All Publications

2012: Estelle Sontag; Andrew Tran; Guocheng Yang; Namita Agrawal; Rebecca Aron; Steven Finkbeiner; Charles G Glabe; Alice Lau; Gregor P Lotz; J Lawrence Marsh; Paul J Muchowski; Mihaela Necula; Leslie M Thompson
Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(32):11109-19.
2012: Haiqun Jia; Alice Lau; J Lawrence Marsh; Judit Pallos; Heather Plasterer; Judith Purcell; James R Rusche; Ghazaleh Sadri-Vakili; Gavin R Sangrey; Shefali Sharma; Adeela Syed; Bin Tang; Yi Chen; Andrew Cooper; Shayna B Darnell; Joel M Gottesfeld; Vincent Jacques; Leslie M Thompson; Elizabeth A Thomas
Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease.
Neurobiology of disease 2012;46(2):351-61.
2012: Laszlo Bodai; Judit Pallos; Leslie Michels Thompson; J Lawrence Marsh
Pcaf modulates polyglutamine pathology in a Drosophila model of Huntington's disease.
Neuro-degenerative diseases 2012;9(2):104-6.
2010: Giulia Ossato; Michelle A Digman; Charity Aiken; Tamas Lukacsovich; J Lawrence Marsh; Enrico Gratton
A two-step path to inclusion formation of huntingtin peptides revealed by number and brightness analysis.
Biophysical journal 2010;98(12):3078-85.
2010: Rakez Kayed; Isabel Canto; Leonid Breydo; Suhail Rasool; Tamas Lukacsovich; Jessica Wu; Ricardo Albay; Anna Pensalfini; Stephen Yeung; Elizabeth Head; J Lawrence Marsh; Charles G Glabe
Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers.
Molecular neurodegeneration 2010;5():57.
2009: Leslie Michels Thompson; Charity T Aiken; Linda S Kaltenbach; Namita Agrawal; Katalin Illes; Ali Khoshnan; Marta Martinez-Vincente; Montserrat Arrasate; Jacqueline Gire O'Rourke; Hasan Khashwji; Tamas Lukacsovich; Ya-Zhen Zhu; Alice L Lau; Ashish Massey; Michael R Hayden; Scott O Zeitlin; Steven Finkbeiner; Kim N Green; Frank M LaFerla; Gillian P Bates; Lan Huang; Paul H Patterson; Donald C Lo; Ana Maria Cuervo; J Lawrence Marsh; Joan S Steffan
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
The Journal of cell biology 2009;187(7):1083-99.
2009: R Najdi; A Syed; L Arce; Heidi Theisen; J-Ht Ting; F Atcha; A V Nguyen; M Martinez; Randall F Holcombe; R A Edwards; J Lawrence Marsh; Marian L Waterman
A Wnt kinase network alters nuclear localization of TCF-1 in colon cancer.
Oncogene 2009;28(47):4133-46.
2009: Charity T Aiken; Joan S Steffan; Cortnie M Guerrero; Hasan Khashwji; Tamas Lukacsovich; Danielle Simmons; Judy M Purcell; Kimia Menhaji; Ya-Zhen Zhu; Kim Green; Frank Laferla; Lan Huang; Leslie Michels Thompson; J Lawrence Marsh
Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity.
The Journal of biological chemistry 2009;284(43):29427-36.
2009: J Lawrence Marsh; Tamas Lukacsovich; Leslie Michels Thompson
Animal models of polyglutamine diseases and therapeutic approaches.
The Journal of biological chemistry 2009;284(12):7431-5.
2008: Judit Pallos; Laszlo Bodai; Tamas Lukacsovich; Judith M Purcell; Joan S Steffan; Leslie Michels Thompson; J Lawrence Marsh
Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease.
Human molecular genetics 2008;17(23):3767-75.
2008: Barbara L Apostol; Danielle A Simmons; Chiara Zuccato; Katalin Illes; Judit Pallos; Malcolm Casale; Paola Conforti; Catarina Ramos; Margaret Roarke; Satish Kathuria; Elena Cattaneo; J Lawrence Marsh; Leslie Michels Thompson
CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice.
Molecular and cellular neurosciences 2008;39(1):8-20.
2007: Fawzia A Atcha; Adeela Syed; Beibei Wu; Nate P Hoverter; Noriko N Yokoyama; Ju-Hui T Ting; Jesus E Munguia; Harry J Mangalam; J Lawrence Marsh; Beibei Wu
A unique DNA binding domain converts T-cell factors into strong Wnt effectors.
Molecular and cellular biology 2007;27(23):8352-63.
2007: Heidi Theisen; Adeela Syed; Baochi T Nguyen; Tamas Lukacsovich; Judith Purcell; Gyan Prakash Srivastava; David Iron; Karin Gaudenz; Qing Nie; Frederic Y M Wan; Marian L Waterman; J Lawrence Marsh
Wingless directly represses DPP morphogen expression via an armadillo/TCF/Brinker complex.
PloS one 2007;2(1):e142.
2007: Erica Rockabrand; Natalia Slepko; Antonello Pantalone; Vidya N Nukala; Aleksey G Kazantsev; J Lawrence Marsh; Patrick G Sullivan; Joan S Steffan; Stefano L Sensi; Leslie Michels Thompson
The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.
Human molecular genetics 2007;16(1):61-77.
2006: J Lawrence Marsh; Leslie Michels Thompson
Drosophila in the study of neurodegenerative disease.
Neuron 2006;52(1):169-78.
2006: Natalia Slepko; Anusri M Bhattacharyya; George R Jackson; Joan S Steffan; J Lawrence Marsh; Leslie Michels Thompson; Ronald B. Wetzel
Normal-repeat-length polyglutamine peptides accelerate aggregation nucleation and cytotoxicity of expanded polyglutamine proteins.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14367-72.
2006: Urvee A Desai; Judit Pallos; Aye Aye K Ma; Brent R Stockwell; Leslie Michels Thompson; J Lawrence Marsh; Marc I Diamond
Biologically active molecules that reduce polyglutamine aggregation and toxicity.
Human molecular genetics 2006;15(13):2114-24.
2006: Barbara L Apostol; Katalin Illes; Judit Pallos; Laszlo Bodai; Jun Wu; Andrew Strand; Erik S Schweitzer; James M Olson; Aleksey G Kazantsev; J Lawrence Marsh; Leslie Michels Thompson
Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity.
Human molecular genetics 2006;15(2):273-85.
2005: Anthony Nguyen; Andrea Rosner; Tatjana Milovanovic; Christopher Hope; Kestutis Planutis; Baisakhi Saha; Benjaporn Chaiwun; Fritz Lin; S Ashraf Imam; J Lawrence Marsh; Randall F Holcombe
Wnt pathway component LEF1 mediates tumor cell invasion and is expressed in human and murine breast cancers lacking ErbB2 (her-2/neu) overexpression.
International journal of oncology 2005;27(4):949-56.
2005: Claudia Mieko Mizutani; Qing Nie; Frederic Y M Wan; Yong-Tao Zhang; Peter Vilmos; Rui Sousa-Neves; Ethan Bier; J Lawrence Marsh; Arthur D Lander
Formation of the BMP activity gradient in the Drosophila embryo.
Developmental cell 2005;8(6):915-24.
2005: T Byun; Misagh Karimi; J Lawrence Marsh; Tatjana Milovanovic; Fritz Lin; Randall F Holcombe
Expression of secreted Wnt antagonists in gastrointestinal tissues: potential role in stem cell homeostasis.
Journal of clinical pathology 2005;58(5):515-9.
2005: Rui Sousa-Neves; Tamas Lukacsovich; Claudia Mieko Mizutani; John Locke; Lynn Podemski; J Lawrence Marsh
High-resolution mapping of the Drosophila fourth chromosome using site-directed terminal deficiencies.
Genetics 2005;170(1):127-38.
2005: Namita Agrawal; Judit Pallos; Natalia Slepko; Barbara L Apostol; Laszlo Bodai; Ling-Wen Chang; Ann-Shyn Chiang; Leslie Michels Thompson; J Lawrence Marsh
Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(10):3777-81.
2005: Peter Vilmos; Rui Sousa-Neves; Tamas Lukacsovich; J Lawrence Marsh
crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling.
EMBO reports 2005;6(3):262-7.
2004: Tatjana Milovanovic; Kestutis Planutis; Anthony Nguyen; J Lawrence Marsh; Fritz Lin; Christopher Hope; Randall F Holcombe
Expression of Wnt genes and frizzled 1 and 2 receptors in normal breast epithelium and infiltrating breast carcinoma.
International journal of oncology 2004;25(5):1337-42.
2004: Lynn Podemski; Rui Sousa-Neves; J Lawrence Marsh; John Locke
Molecular mapping of deletion breakpoints on chromosome 4 of Drosophila melanogaster.
Chromosoma 2004;112(8):381-8.
2004: J Lawrence Marsh; Leslie Michels Thompson
Can flies help humans treat neurodegenerative diseases?
BioEssays : news and reviews in molecular, cellular and developmental biology 2004;26(5):485-96.
2004: Joan S Steffan; Namita Agrawal; Judit Pallos; Erica Rockabrand; Lloyd C Trotman; Natalia Slepko; Katalin Illes; Tamas Lukacsovich; Ya-Zhen Zhu; Elena Cattaneo; Pier Paolo Pandolfi; Leslie Michels Thompson; J Lawrence Marsh
SUMO modification of Huntingtin and Huntington's disease pathology.
Science (New York, N.Y.) 2004;304(5667):100-4.
2003: Laszlo Bodai; Judit Pallos; Leslie Michels Thompson; J Lawrence Marsh
Altered protein acetylation in polyglutamine diseases.
Current medicinal chemistry 2003;10(23):2577-87.
2003: Sonia K Pollitt; Judit Pallos; Jieya Shao; Urvee A Desai; Aye Aye K Ma; Leslie Michels Thompson; J Lawrence Marsh; Marc I Diamond
A rapid cellular FRET assay of polyglutamine aggregation identifies a novel inhibitor.
Neuron 2003;40(4):685-94.
2003: J Lawrence Marsh; Judit Pallos; Leslie Michels Thompson
Fly models of Huntington's disease.
Human molecular genetics 2003;12 Spec No 2():R187-93.
2003: Leslie Michels Thompson; J Lawrence Marsh
Invertebrate models of neurologic disease: insights into pathogenesis and therapy.
Current neurology and neuroscience reports 2003;3(5):442-8.
2003: Barbara L Apostol; Aleksey G Kazantsev; Simona Raffioni; Katalin Illes; Judit Pallos; Laszlo Bodai; Natalia Slepko; James E Bear; Frank B Gertler; Steven M Hersch; David E Housman; J Lawrence Marsh; Leslie Michels Thompson
A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):5950-5.
2003: Emma Hockly; Victoria M Richon; Ben Woodman; Donna L Smith; Xianbo Zhou; Eddie Rosa; Kirupa Sathasivam; Shabnam Ghazi-Noori; Amarbirpal Mahal; Philip A S Lowden; Joan S Steffan; J Lawrence Marsh; Leslie Michels Thompson; Cathryn M Lewis; Paul A Marks; Gillian P Bates
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):2041-6.
2002: Randall F Holcombe; J Lawrence Marsh; Marian L Waterman; Fritz Lin; Tatjana Milovanovic; T Truong
Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma.
Molecular pathology : MP 2002;55(4):220-6.
2002: Aleksey G Kazantsev; Heli A Walker; Natalia Slepko; James E Bear; Elizabeth Preisinger; Joan S Steffan; Ya-Zhen Zhu; Frank B Gertler; David E Housman; J Lawrence Marsh; Leslie Michels Thompson
A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila.
Nature genetics 2002;30(4):367-76.
2001: Joan S Steffan; Laszlo Bodai; Judit Pallos; M Poelman; A McCampbell; Barbara L Apostol; Aleksey G Kazantsev; E Schmidt; Ya-Zhen Zhu; M Greenwald; R Kurokawa; David E Housman; G R Jackson; J Lawrence Marsh; Leslie Michels Thompson
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.
Nature 2001;413(6857):739-43.
2001: Peter Vilmos; Karin Gaudenz; Z Hegedus; J Lawrence Marsh
The Twisted gastrulation family of proteins, together with the IGFBP and CCN families, comprise the TIC superfamily of cysteine rich secreted factors.
Molecular pathology : MP 2001;54(5):317-23.
2001: J J Ross; Osamu Shimmi; Peter Vilmos; Anna Petryk; H Kim; Karin Gaudenz; Spencer B Hermanson; Stephen C Ekker; Michael B O'Connor; J Lawrence Marsh
Twisted gastrulation is a conserved extracellular BMP antagonist.
Nature 2001;410(6827):479-83.
2000: J Lawrence Marsh; H Walker; Heidi Theisen; Y Z Zhu; T Fielder; J Purcell; L M Thompson
Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila.
Human molecular genetics 2000;9(1):13-25.
1999: J Lawrence Marsh; Heidi Theisen
Regeneration in insects.
Seminars in cell & developmental biology 1999;10(4):365-75.
1999: O Marcu; DG Stathakis; J Lawrence Marsh
Assignment of the UGDH locus encoding UDP-glucose dehydrogenase to human chromosome band 4p15.1 by radiation hybrid mapping.
Cytogenetics and cell genetics 1999;86(3-4):244-5.
1998: Richard H Lathrop; Malcolm Casale; Douglas J Tobias; J Lawrence Marsh; Leslie Michels Thompson
Modeling protein homopolymeric repeats: possible polyglutamine structural motifs for Huntington's disease.
Proceedings / ... International Conference on Intelligent Systems for Molecular Biology ; ISMB. International Conference on Intelligent Systems for Molecular Biology 1998;6():105-14.
1997: Theodor E Haerry; T R Heslip; J Lawrence Marsh; Michael B O'Connor
Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila.
Development (Cambridge, England) 1997;124(16):3055-64.
1997: T R Heslip; Heidi Theisen; H Walker; J Lawrence Marsh
Shaggy and dishevelled exert opposite effects on Wingless and Decapentaplegic expression and on positional identity in imaginal discs.
Development (Cambridge, England) 1997;124(5):1069-78.
1996: Heidi Theisen; Theodor E Haerry; Michael B O'Connor; J Lawrence Marsh
Developmental territories created by mutual antagonism between Wingless and Decapentaplegic.
Development (Cambridge, England) 1996;122(12):3939-48.
1996: D Wang; J Lawrence Marsh; Francisco J Ayala
Evolutionary changes in the expression pattern of a developmentally essential gene in three Drosophila species.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):7103-7.
1995: A Grens; E Mason; J Lawrence Marsh; Hans R Bode
Evolutionary conservation of a cell fate specification gene: the Hydra achaete-scute homolog has proneural activity in Drosophila.
Development (Cambridge, England) 1995;121(12):4027-35.
1994: H Theisen; J Purcell; M Bennett; D Kansagara; A Syed; J Lawrence Marsh
dishevelled is required during wingless signaling to establish both cell polarity and cell identity.
Development (Cambridge, England) 1994;120(2):347-60.
1992: L J Scherer; J D McPherson; JJ Wasmuth; J Lawrence Marsh
Human dopa decarboxylase: localization to human chromosome 7p11 and characterization of hepatic cDNAs.
Genomics 1992;13(2):469-71.