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Kenneth Bastow

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TOP 3
Qi Wang; Kenneth F Bastow; Tzu-Hsuan Chen; Kuo-Hsiung Lee; Susan L Morris-Natschke; Dao-Feng Chen
Songaricalarins A-E, cytotoxic oplopane sesquiterpenes from Ligularia songarica.
Xiao-Feng Wang; Kenneth F Bastow; Ernest Hamel; Kuo-Hsiung Lee; Susan L Morris-Natschke; Emika Ohkoshi; Sheng-Biao Wang; Lan Xie
Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin-2-amines as a new class of tubulin polymerization inhibitors.
Xiao-Feng Wang; Pei-Chi Wu; Kenneth F Bastow; Mann-Jen Hour; Rong Huang; Hsin-Yi Hung; William P Janzen; Jian Jin; Kuo-Hsiung Lee; Yi-Nan Liu; Susan L Morris-Natschke; Emika Ohkoshi; Keduo Qian; Bingjie Qin; Xing-Tao Tian; Lan Xie
Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents.

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All Publications

2013: Qi Wang; Kenneth F Bastow; Tzu-Hsuan Chen; Kuo-Hsiung Lee; Susan L Morris-Natschke; Dao-Feng Chen
Songaricalarins A-E, cytotoxic oplopane sesquiterpenes from Ligularia songarica.
Journal of natural products 2013;76(3):305-10.
2013: Xiao-Feng Wang; Kenneth F Bastow; Ernest Hamel; Kuo-Hsiung Lee; Susan L Morris-Natschke; Emika Ohkoshi; Sheng-Biao Wang; Lan Xie
Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin-2-amines as a new class of tubulin polymerization inhibitors.
Bioorganic & medicinal chemistry 2013;21(3):632-42.
2012: Xiao-Feng Wang; Pei-Chi Wu; Kenneth F Bastow; Mann-Jen Hour; Rong Huang; Hsin-Yi Hung; William P Janzen; Jian Jin; Kuo-Hsiung Lee; Yi-Nan Liu; Susan L Morris-Natschke; Emika Ohkoshi; Keduo Qian; Bingjie Qin; Xing-Tao Tian; Lan Xie
Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents.
Bioorganic & medicinal chemistry letters 2012;22(19):6224-8.
2012: Xiaoming Yang; Kenneth F Bastow; Chi-Yuan Chen; Chin-Yu Lai; Emika Ohkoshi; Shiow-Lin Pan; Qian Shi; Che-Ming Teng; Chih-Ya Wang; Tian-Shung Wu; Pan-Chyr Yang; Shuenn-chen YANG; Kuo-Hsiung Lee
Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies.
Journal of medicinal chemistry 2012;55(15):6751-61.
2012: Chiao-Ting Yen; Kenneth F Bastow; Tsong-Long Hwang; Susan L Morris-Natschke; Kyoko Goto; Yang-Chang Wu; Kuo-Hsiung Lee
Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents.
Bioorganic & medicinal chemistry letters 2012;22(12):4018-22.
2012: Hsin-Yi Hung; Kenneth F Bastow; Masuo Goto; Kyoko Goto; Emika Ohkoshi; Kuo-Hsiung Lee
Antitumor agents. 293. Nontoxic dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs.
Journal of medicinal chemistry 2012;55(11):5413-24.
2012: Ting Zhou; Kenneth F Bastow; Emika Ohkoshi; Qian Shi; Kuo-Hsiung Lee
Anti-AIDS agents 89. Identification of DCX derivatives as anti-HIV and chemosensitizing dual function agents to overcome P-gp-mediated drug resistance for AIDS therapy.
Bioorganic & medicinal chemistry letters 2012;22(9):3219-22.
2012: Yizhou Dong; Yoon Kim; Chin-Yu Lai; Eva Y-H P Lee; Susan L Morris-Natschke; Kyoko Goto; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents. 289. Design, synthesis, and anti-breast cancer activity in vivo of 4-amino-2H-benzo[h]chromen-2-one and 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogues with improved water solubility.
Journal of natural products 2012;75(3):370-7.
2012: M Vijaya Bhaskar Reddy; Kenneth F Bastow; Kuo-Hsiung Lee; Emika Ohkoshi; Keduo Qian; Yuh-Chiang Shen; Tian-Shung Wu
Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents.
European journal of medicinal chemistry 2012;47(1):97-103.
2011: Xiaoming Yang; Sung-Liang Yu; Kenneth F Bastow; Chi-Yuan Chen; Chin-Yu Lai; Jau-Chen Lin; Susan L Morris-Natschke; Shiow-Lin Pan; Qian Shi; Che-Ming Teng; Pei-Chi Wu; Tian-Shung Wu; Pan-Chyr Yang; Shuenn-chen YANG; Kuo-Hsiung Lee
Antitumor agents 288: design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents.
Journal of medicinal chemistry 2011;54(14):5097-107.
2011: Ting-Chun Kuo; Po-Cheng Chiang; Chia-Chun Yu; Kyoko Goto; Kenneth F Bastow; Kuo-Hsiung Lee; Jih-Hwa Guh
A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways.
Biochemical pharmacology 2011;81(9):1136-44.
2011: Hsiu-Hui Chan; Tsong-Long Hwang; Mopur Vijaya Bhaskar Reddy; Ding-Tzai Li; Keduo Qian; Kenneth F Bastow; Kuo-Hsiung Lee; Tian-Shung Wu
Bioactive constituents from the roots of Panax japonicus var. major and development of a LC-MS/MS method for distinguishing between natural and artifactual compounds.
Journal of natural products 2011;74(4):796-802.
2011: Yizhou Dong; Kyoko Goto; Chin-Yu Lai; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity.
Bioorganic & medicinal chemistry letters 2011;21(8):2341-4.
2011: M Vijaya Bhaskar Reddy; Yuh-Chiang Shen; Jai-Sing Yang; Tsong-Long Hwang; Kenneth F Bastow; Keduo Qian; Kuo-Hsiung Lee; Tian-Shung Wu
New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis.
Bioorganic & medicinal chemistry 2011;19(6):1895-906.
2011: Kyoko Goto; Pei-Chi Wu; Chin-Yu Lai; Ernest Hamel; Hao Zhu; Liying Zhang; Takashi Kozaka; Emika Ohkoshi; Masuo Goto; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents.
Journal of medicinal chemistry 2011;54(5):1244-55.
2011: Kyoko Goto; Pei-Chi Wu; Kenneth F Bastow; Shuenn-chen YANG; Sung-Liang Yu; Hsuan-Yu Chen; Jau-Chen Lin; Masuo Goto; Susan L Morris-Natschke; Pan-Chyr Yang; Kuo-Hsiung Lee
Antitumor agents 283. Further elaboration of desmosdumotin C analogs as potent antitumor agents: activation of spindle assembly checkpoint as possible mode of action.
Bioorganic & medicinal chemistry 2011;19(5):1816-22.
2011: Yizhou Dong; Kyoko Goto; Chin-Yu Lai; Yoon Kim; Susan L Morris-Natschke; Eva Y-H P Lee; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents 279. Structure-activity relationship and in vivo studies of novel 2-(furan-2-yl)naphthalen-1-ol (FNO) analogs as potent and selective anti-breast cancer agents.
Bioorganic & medicinal chemistry letters 2011;21(1):52-7.
2011: Yizhou Dong; Kyoko Goto; Chin-Yu Lai; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents.
Bioorganic & medicinal chemistry letters 2011;21(1):546-9.
2010: Ting Zhou; Qian Shi; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents 286. Design, synthesis, and structure-activity relationships of 3'R,4'R-disubstituted-2',2'-dimethyldihydropyrano[2,3-f]chromone (DSP) analogues as potent chemosensitizers to overcome multidrug resistance.
Journal of medicinal chemistry 2010;53(24):8700-8.
2010: Yoshihide Usami; Kyoko Goto; Jing-Yu Lang; Yoon Kim; Chin-Yu Lai; Masuo Goto; Nobuko Sakurai; Masahiko Taniguchi; Toshiyuki Akiyama; Susan L Morris-Natschke; Kenneth F Bastow; Gordon Cragg; David J Newman; Mihoyo Fujitake; Koichi Takeya; Mien-Chie Hung; Eva Y-H P Lee; Kuo-Hsiung Lee
Antitumor Agents. 282. 2'-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent.
Journal of natural products 2010;73(9):1553-8.
2010: Kyoko Goto; Po-Cheng Chang; Chin-Yu Lai; Hsin-Yi Hung; Tzu-Hsuan Chen; Pei-Chi Wu; Hao Zhu; Alexander Sedykh; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents. 280. Multidrug resistance-selective desmosdumotin B analogues.
Journal of medicinal chemistry 2010;53(18):6699-705.
2010: Yizhou Dong; Kyoko Goto; Chin-Yu Lai; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents.
Bioorganic & medicinal chemistry letters 2010;20(14):4085-7.
2010: Takashi Kozaka; Kyoko Goto; Qian Shi; Chin-Yu Lai; Ernest Hamel; Kenneth F Bastow; Arnold Brossi; Kuo-Hsiung Lee
Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents.
Bioorganic & medicinal chemistry letters 2010;20(14):4091-4.
2010: Sergio Rosselli; Antonella Maggio; Rosa Angela Raccuglia; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee; Maurizio Bruno
Acid rearrangment of epoxy-germacranolides and absolute configuration of 1beta,10alpha-epoxy-salonitenolide.
Natural product communications 2010;5(5):675-80.
2010: Xiaoming Yang; Qian Shi; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents. 274. A new synthetic strategy for E-ring SAR study of antofine and cryptopleurine analogues.
Organic letters 2010;12(7):1416-9.
2010: Yizhou Dong; Qian Shi; Huei-Chen Pai; Chieh-Yu Peng; Shiow-Lin Pan; Che-Ming Teng; Kyoko Goto; Donglei Yu; Yi-Nan Liu; Pei-Chi Wu; Kenneth F Bastow; Susan L Morris-Natschke; Arnold Brossi; Jing-Yu Lang; Jennifer L Hsu; Mien-Chie Hung; Eva Y-H P Lee; Kuo-Hsiung Lee
Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues.
Journal of medicinal chemistry 2010;53(5):2299-308.
2010: Qi Wang; Tzu-Hsuan Chen; Kenneth F Bastow; Kuo-Hsiung Lee; Dao-Feng Chen
Altaicalarins A-D, cytotoxic bisabolane sesquiterpenes from Ligularia altaica.
Journal of natural products 2010;73(2):139-42.
2010: Chiao-Ting Yen; Kyoko Goto; Tsong-Long Hwang; Pei-Chi Wu; Susan L Morris-Natschke; Wan-Chun Lai; Kenneth F Bastow; Fang-Rong Chang; Yang-Chang Wu; Kuo-Hsiung Lee
Antitumor agents. 271: total synthesis and evaluation of brazilein and analogs as anti-inflammatory and cytotoxic agents.
Bioorganic & medicinal chemistry letters 2010;20(3):1037-9.
2010: Yizhou Dong; Qian Shi; Kyoko Goto; Pei-Chi Wu; Susan L Morris-Natschke; Arnold Brossi; Kenneth F Bastow; Jing-Yu Lang; Mien-Chie Hung; Kuo-Hsiung Lee
Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents.
Bioorganic & medicinal chemistry 2010;18(2):803-8.
2009: Sergio Rosselli; Antonella Maggio; Nicoletta Faraone; Vivienne Spadaro; Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee; Maurizio Bruno
The cytotoxic properties of natural coumarins isolated from roots of Ferulago campestris (Apiaceae) and of synthetic ester derivatives of aegelinol.
Natural product communications 2009;4(12):1701-6.
2009: Yizhou Dong; Qian Shi; Kyoko Goto; Pei-Chi Wu; Kenneth F Bastow; Susan L Morris-Natschke; Kuo-Hsiung Lee
Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.
Bioorganic & medicinal chemistry letters 2009;19(22):6289-92.
2009: Chung-Ren Su; Sheau-Farn Yeh; Chih Miem Liu; Amooru G Damu; Tsung-Hsiao Kuo; Po-Cheng Chiang; Kenneth F Bastow; Kuo-Hsiung Lee; Tian-Shung Wu
Anti-HBV and cytotoxic activities of pyranocoumarin derivatives.
Bioorganic & medicinal chemistry 2009;17(16):6137-43.
2009: Yizhou Dong; Qian Shi; Yi-Nan Liu; Xiang Wang; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents.
Journal of medicinal chemistry 2009;52(11):3586-90.
2009: Chia-Lin Lee; Fang-Rong Chang; Ming-Hon Yen; Donglei Yu; Yi-Nan Liu; Kenneth F Bastow; Susan L Morris-Natschke; Yang-Chang Wu; Kuo-Hsiung Lee
Cytotoxic phenanthrenequinones and 9,10-dihydrophenanthrenes from Calanthe arisanensis.
Journal of natural products 2009;72(2):210-3.
2008: Gang Wu; Huan-Fang Guo; Kun Gao; Yi-Nan Liu; Kenneth F Bastow; Susan L Morris-Natschke; Kuo-Hsiung Lee; Lan Xie
Synthesis of unsymmetrical biphenyls as potent cytotoxic agents.
Bioorganic & medicinal chemistry letters 2008;18(19):5272-6.
2008: Chia-Lin Lee; Kyoko Goto; Donglei Yu; Yi-Nan Liu; Kenneth F Bastow; Susan L Morris-Natschke; Fang-Rong Chang; Yang-Chang Wu; Kuo-Hsiung Lee
Cytotoxic calanquinone A from Calanthe arisanensis and its first total synthesis.
Bioorganic & medicinal chemistry letters 2008;18(15):4275-7.
2008: M Vijaya Bhaskar Reddy; Chung-Ren Su; Wen-Fei Chiou; Yi-Nan Liu; Rosemary Yin-Hwa Chen; Kenneth F Bastow; Kuo-Hsiung Lee; Tian-Shung Wu
Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents.
Bioorganic & medicinal chemistry 2008;16(15):7358-70.
2008: Kyoko Goto; Kenneth F Bastow; Tzu-Hsuan Chen; Susan L Morris-Natschke; Kuo-Hsiung Lee
Antitumor agents 260. New desmosdumotin B analogues with improved in vitro anticancer activity.
Journal of medicinal chemistry 2008;51(11):3297-303.
2008: Chung-Ren Su; Amooru G Damu; Po-Cheng Chiang; Kenneth F Bastow; Susan L Morris-Natschke; Kuo-Hsiung Lee; Tian-Shung Wu
Total synthesis of phenanthroindolizidine alkaloids (+/-)-antofine, (+/-)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity.
Bioorganic & medicinal chemistry 2008;16(11):6233-41.
2008: Chieh-Yu Peng; Shiow-Lin Pan; Kuo-Hsiung Lee; Kenneth F Bastow; Che-Ming Teng
Molecular mechanism of the inhibitory effect of KS-5 on bFGF-induced angiogenesis in vitro and in vivo.
Cancer letters 2008;263(1):114-21.
2008: Yoshihide Usami; Yi-Nan Liu; An-Shen Lin; Makio Shibano; Toshiyuki Akiyama; Hideji Itokawa; Susan L Morris-Natschke; Kenneth F Bastow; Ryoji Kasai; Kuo-Hsiung Lee
Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)H NMR spectra.
Journal of natural products 2008;71(3):478-81.
2007: Kyoko Goto; Koji Yamada; Seikou Nakamura; Tzu-Hsuan Chen; Po-Cheng Chiang; Kenneth F Bastow; Shao-Chun Wang; Bill Spohn; Mien-Chie Hung; Fang-Yu Lee; Fang-Chen Lee; Kuo-Hsiung Lee
Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant--taxoid conjugates as novel cytotoxic agents.
Bioorganic & medicinal chemistry letters 2007;17(18):5204-9.
2007: Jin Tatsuzaki; Masahiko Taniguchi; Kenneth F Bastow; Kyoko Goto; Susan L Morris-Natschke; Hideji Itokawa; Kimiye Baba; Kuo-Hsiung Lee
Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents.
Bioorganic & medicinal chemistry 2007;15(18):6193-9.
2007: Li-Bo Zhou; Tzu-Hsuan Chen; Kenneth F Bastow; Makio Shibano; Kuo-Hsiung Lee; Dao-Feng Chen
Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus.
Journal of natural products 2007;70(8):1263-7.
2007: Linyi Wei; Qian Shi; Kenneth F Bastow; Arnold Brossi; Susan L Morris-Natschke; Kyoko Goto; Tian-Shung Wu; Shiow-Lin Pan; Che-Ming Teng; Kuo-Hsiung Lee
Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents.
Journal of medicinal chemistry 2007;50(15):3674-80.
2007: Kyoko Goto; Tzu-Hsuan Chen; Chieh-Yu Peng; Kenneth F Bastow; Jiu-Hong Wu; Kuo-Hsiung Lee
Antitumor agents 259. Design, syntheses, and structure-activity relationship study of desmosdumotin C analogs.
Journal of medicinal chemistry 2007;50(14):3354-8.
2007: Amooru G Damu; Ping-Chung Kuo; Chung-Ren Su; Tsung-Hsiao Kuo; Tzu-Hsuan Chen; Kenneth F Bastow; Kuo-Hsiung Lee; Tian-Shung Wu
Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata.
Journal of natural products 2007;70(7):1146-52.
2007: Kyoko Goto; Seikou Nakamura; Kenneth F Bastow; Alexander Nyarko; Chieh-Yu Peng; Fang-Yu Lee; Fang-Chen Lee; Kuo-Hsiung Lee
Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents.
Bioorganic & medicinal chemistry letters 2007;17(10):2894-8.
2007: Sergio Rosselli; Maurizio Bruno; Antonella Maggio; Gabriella Bellone; Tzu-Hsuan Chen; Kenneth F Bastow; Kuo-Hsiung Lee
Cytotoxic activity of some natural and synthetic ent-kauranes.
Journal of natural products 2007;70(3):347-52.
2007: Shuxing Zhang; Linyi Wei; Kenneth F Bastow; Weifan Zheng; Arnold Brossi; Kuo-Hsiung Lee; Alexander Tropsha
Antitumor agents 252. Application of validated QSAR models to database mining: discovery of novel tylophorine derivatives as potential anticancer agents.
Journal of computer-aided molecular design 2007;21(1-3):97-112.
2006: Pei-Lin Wu; Yu-Lin Hsu; Tian-Shung Wu; Kenneth F Bastow; Kuo-Hsiung Lee
Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis.
Organic letters 2006;8(23):5207-10.
2006: Jin Tatsuzaki; Kenneth F Bastow; Kyoko Goto; Seiko Nakamura; Hideji Itokawa; Kuo-Hsiung Lee
Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents.
Journal of natural products 2006;69(10):1445-9.
2006: Linyi Wei; Arnold Brossi; Ross Kendall; Kenneth F Bastow; Susan L Morris-Natschke; Qian Shi; Kuo-Hsiung Lee
Antitumor agents 251: synthesis, cytotoxic evaluation, and structure-activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents.
Bioorganic & medicinal chemistry 2006;14(19):6560-9.
2006: Xihong Wang; Kyoko Goto; Kenneth F Bastow; Ming-Jaw Don; Yun-Lian Lin; Tian-Shung Wu; Kuo-Hsiung Lee
Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents.
Journal of medicinal chemistry 2006;49(18):5631-4.
2006: Masafumi Horiuch; Chihiro Murakami; Narihiko Fukamiya; Donglei Yu; Tzu-Hsuan Chen; Kenneth F Bastow; De-Cheng Zhang; Yoshihisa Takaishi; Yasuhiro Imakura; Kuo-Hsiung Lee
Tripfordines A-C, sesquiterpene pyridine alkaloids from Tripterygium wilfordii, and structure anti-HIV activity relationships of Tripterygium alkaloids.
Journal of natural products 2006;69(9):1271-4.
2006: Ping-Chung Kuo; Tsung-Hsiao Kuo; Amooru G Damu; Chung-Ren Su; E-Jian Lee; Tian-Shung Wu; Rexen Shu; Chou-Ming Chen; Kenneth F Bastow; Tzu-Hsuan Chen; Kuo-Hsiung Lee
Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata.
Organic letters 2006;8(14):2953-6.
2006: Li Lin; Qian Shi; Alexander K Nyarko; Kenneth F Bastow; Chin-Chung Wu; Ching-Yuan Su; Charles C-Y Shih; Kuo-Hsiung Lee
Antitumor agents. 250. Design and synthesis of new curcumin analogues as potential anti-prostate cancer agents.
Journal of medicinal chemistry 2006;49(13):3963-72.
2006: Nobuko Sakurai; Kyoko Goto; Junko Ito; Yojiro Sakurai; Yuka Nakanishi; Kenneth F Bastow; Gordon Cragg; Kuo-Hsiung Lee
Cytotoxic Alangium alkaloids from Alangium longiflorum.
Phytochemistry 2006;67(9):894-7.
2006: Pannarat Akanitapichat; Aree Wangmaneerat; Prapon Wilairat; Kenneth F Bastow
Anti-herpes virus activity of Dunbaria bella Prain.
Journal of ethnopharmacology 2006;105(1-2):64-8.
2006: Yojiro Sakurai; Nobuko Sakurai; Masahiko Taniguchi; Yuka Nakanishi; Kenneth F Bastow; Xihong Wang; Gordon Cragg; Kuo-Hsiung Lee
Rautandiols A and B, pterocarpans and cytotoxic constituents from Neorautanenia mitis.
Journal of natural products 2006;69(3):397-9.
2005: Maurizio Bruno; Sergio Rosselli; Antonella Maggio; Rosa Angela Raccuglia; Kenneth F Bastow; Chin-Chung Wu; Kuo-Hsiung Lee
Cytotoxic activity of some natural and synthetic sesquiterpene lactones.
Planta medica 2005;71(12):1176-8.
2005: Seikou Nakamura; Mutsuo Kozuka; Kenneth F Bastow; Harukuni Tokuda; Hoyoku Nishino; Madoka Suzuki; Jin Tatsuzaki; Susan L Morris-Natschke; Sheng-Chu Kuo; Kuo-Hsiung Lee
Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters.
Bioorganic & medicinal chemistry 2005;13(14):4396-401.
2005: Maurizio Bruno; Sergio Rosselli; Antonella Maggio; Rosa Angela Raccuglia; Kenneth F Bastow; Kuo-Hsiung Lee
Cytotoxic activity of some natural and synthetic guaianolides.
Journal of natural products 2005;68(7):1042-6.
2005: Kyoko Goto; Kenneth F Bastow; Jiu-Hong Wu; Harukuni Tokuda; Kuo-Hsiung Lee
Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs.
Bioorganic & medicinal chemistry letters 2005;15(12):3016-9.
2005: Kyoko Goto; Jiu-Hong Wu; Kenneth F Bastow; Chin-Chung Wu; Kuo-Hsiung Lee
Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives.
Bioorganic & medicinal chemistry 2005;13(6):2325-30.
2005: Ya-Yun Lai; Li-Jiau Huang; Kuo-Hsiung Lee; Zhiyan Xiao; Kenneth F Bastow; Takao Yamori; Sheng-Chu Kuo
Synthesis and biological relationships of 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents.
Bioorganic & medicinal chemistry 2005;13(1):265-75.
2005: Kyoko Goto; Cyril X Chen; Ernest Hamel; Chin-Chung Wu; Kenneth F Bastow; Arnold Brossi; Kuo-Hsiung Lee
Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives.
Bioorganic & medicinal chemistry letters 2005;15(1):235-8.
2004: Kenneth F Bastow
New acridone inhibitors of human herpes virus replication.
Current drug targets. Infectious disorders 2004;4(4):323-30.
2004: Xihong Wang; Kenneth F Bastow; Chang-Ming Sun; Yun-Lian Lin; Hsi-Jung Yu; Ming-Jaw Don; Tian-Shung Wu; Seikou Nakamura; Kuo-Hsiung Lee
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
Journal of medicinal chemistry 2004;47(23):5816-9.
2004: Naonobu Tanaka; Yoshihisa Takaishi; Yasuhiro Shikishima; Yuka Nakanishi; Kenneth F Bastow; Kuo-Hsiung Lee; Gisho Honda; Michiho Ito; Yoshio Takeda; Olimjon K Kodzhimatov; Ozodbek Ashurmetov
Prenylated benzophenones and xanthones from Hypericum scabrum.
Journal of natural products 2004;67(11):1870-5.
2004: Chih-Chuang Liaw; Fang-Rong Chang; Yang-Chang Wu; Hui-Kang Wang; Yuka Nakanishi; Kenneth F Bastow; Kuo-Hsiung Lee
Montacin and cis-montacin, two new cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona montana.
Journal of natural products 2004;67(11):1804-8.
2004: Zhiyan Xiao; Kenneth F Bastow; John R Vance; Robert S Sidwell; Hui-Kang Wang; Ming S Chen; Qian Shi; Kuo-Hsiung Lee
Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives.
Journal of medicinal chemistry 2004;47(21):5140-8.
2004: Chih-Chuang Liaw; Fang-Rong Chang; Chin-Chung Wu; Shu-Li Chen; Kenneth F Bastow; Ken-ichiro Hayashi; Hiroshi Nozaki; Kuo-Hsiung Lee; Yang-Chang Wu
Nine new cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana.
Planta medica 2004;70(10):948-59.
2004: Chihiro Murakami; Narihiko Fukamiya; Sadaaki Tamura; Masayoshi Okano; Kenneth F Bastow; Harukuni Tokuda; Teruo Mukainaka; Hoyoky Nishino; Kuo-Hsiung Lee
Multidrug-resistant cancer cell susceptibility to cytotoxic quassinoids, and cancer chemopreventive effects of quassinoids and canthin alkaloids.
Bioorganic & medicinal chemistry 2004;12(18):4963-8.
2004: Naonobu Tanaka; Nobuyuki Ooba; Hongquan Duan; Yoshihisa Takaishi; Yuka Nakanishi; Kenneth F Bastow; Kuo-Hsiung Lee
Kaurane and abietane diterpenoids from Tripterygium doianum (Celastraceae).
Phytochemistry 2004;65(14):2071-6.
2004: Zhiyan Xiao; John R Vance; Kenneth F Bastow; Arnold Brossi; Hui-Kang Wang; Kuo-Hsiung Lee
Antitumor agents. Part 235: Novel 4'-ester etoposide analogues as potent DNA topoisomerase II inhibitors with improved therapeutic potential.
Bioorganic & medicinal chemistry 2004;12(12):3363-9.
2004: Zhiyan Xiao; Kenneth F Bastow; John R Vance; Kuo-Hsiung Lee
Antitumor agents. Part 227: Studies on novel 4'-O-demethyl-epipodophyllotoxins as antitumor agents targeting topoisomerase II.
Bioorganic & medicinal chemistry 2004;12(12):3339-44.
2004: Shiqing Han; Zhiyan Xiao; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents. Part 230: C4'-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(11):2979-82.
2004: Kenichiro Hayashi; Fang-Rong Chang; Yuka Nakanishi; Kenneth F Bastow; Gordon Cragg; Andrew T McPhail; Hiroshi Nozaki; Kuo-Hsiung Lee
Antitumor agents. 233. Lantalucratins A-F, new cytotoxic naphthoquinones from Lantana involucrata.
Journal of natural products 2004;67(6):990-3.
2004: Yong-Hong Wang; Ai-Jun Hou; Lei Chen; Dao-Feng Chen; Han-Dong Sun; Qin-Shi Zhao; Kenneth F Bastow; Yuka Nakanish; Xi-Hong Wang; Kuo-Hsiung Lee
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
Journal of natural products 2004;67(5):757-61.
2004: Zhiyan Xiao; Shiqing Han; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents.
Bioorganic & medicinal chemistry letters 2004;14(6):1581-4.
2003: Christopher T Lowden; Kenneth F Bastow
Anti-herpes simplex virus activity of substituted 1-hydroxyacridones.
Journal of medicinal chemistry 2003;46(23):5015-20.
2003: Fang-Rong Chang; Kenichiro Hayashi; I-Hsiao Chen; Chih-Chuang Liaw; Kenneth F Bastow; Yuka Nakanishi; Hiroshi Nozaki; Gordon Cragg; Yang-Chang Wu; Kuo-Hsiung Lee
Antitumor agents. 228. five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii.
Journal of natural products 2003;66(11):1416-20.
2003: Ping-Chung Kuo; Li-Shian Shi; Amooru G Damu; Chung-Ren Su; Chieh-Hung Huang; Chih-Huang Ke; Jin-Bin Wu; Ai-Jeng Lin; Kenneth F Bastow; Kuo-Hsiung Lee; Tian-Shung Wu
Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia.
Journal of natural products 2003;66(10):1324-7.
2003: Yi Xia; Zheng-Yu Yang; Peng Xia; Kenneth F Bastow; Yuka Nakanishi; Priya Nampoothiri; Ernest Hamel; Arnold Brossi; Kuo-Hsiung Lee
Antitumor agents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters.
Bioorganic & medicinal chemistry letters 2003;13(17):2891-3.
2003: Christopher T Lowden; Kenneth F Bastow
Cell culture replication of herpes simplex virus and, or human cytomegalovirus is inhibited by 3,7-dialkoxylated, 1-hydroxyacridone derivatives.
Antiviral research 2003;59(3):143-54.
2003: Yuka Nakanishi; Fang-Rong Chang; Chih-Chuang Liaw; Yang-Chang Wu; Kenneth F Bastow; Kuo-Hsiung Lee
Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.
Journal of medicinal chemistry 2003;46(15):3185-8.
2003: Jiu-Hong Wu; Fang-Rong Chang; Kenichiro Hayashi; Hiroaki Shiraki; Chih-Chuang Liaw; Yuka Nakanishi; Kenneth F Bastow; Donglei Yu; Ih-Sheng Chen; Kuo-Hsiung Lee
Antitumor agents. Part 218: Cappamensin A, a new In vitro anticancer principle, from Capparis sikkimensis.
Bioorganic & medicinal chemistry letters 2003;13(13):2223-5.
2003: Hironori Ohtsu; Yuka Nakanishi; Kenneth F Bastow; Fang-Yu Lee; Kuo-Hsiung Lee
Antitumor agents 216. Synthesis and evaluation of paclitaxel-camptothecin conjugates as novel cytotoxic agents.
Bioorganic & medicinal chemistry 2003;11(8):1851-7.
2003: Qian Zhang; Ying Chen; Yun Qing Zheng; Peng Xia; Yi Xia; Zheng Yu Yang; Kenneth F Bastow; Susan L Morris-Natschke; Kuo-Hsiung Lee
Synthesis and bioactivity of 4,10-dimethyl-pyridino[2,3-h]quinolin-2(1H)-one-9-carboxylic acid and its esters.
Bioorganic & medicinal chemistry 2003;11(6):1031-4.
2003: Kenichiro Hayashi; Yuka Nakanishi; Kenneth F Bastow; Gordon Cragg; Hiroshi Nozaki; Kuo-Hsiung Lee
Antitumor agents. 221.1 buceracidins A and B, two new flavanones from Bucida buceras.
Journal of natural products 2003;66(1):125-7.
2002: Junko Ishida; Hironori Ohtsu; Yoko Tachibana; Yuka Nakanishi; Kenneth F Bastow; Masahiro Nagai; Hui-Kang Wang; Hideji Itokawa; Kuo-Hsiung Lee
Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents.
Bioorganic & medicinal chemistry 2002;10(11):3481-7.
2002: Shiqing Han; Ernest Hamel; Kenneth F Bastow; Andrew T McPhail; Arnold Brossi; Kuo-Hsiung Lee
Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.
Bioorganic & medicinal chemistry letters 2002;12(20):2851-3.
2002: Youichi Shinozaki; Narihiko Fukamiya; Chieko Uchiyama; Masayoshi Okano; Kiyoshi Tagahara; Kenneth F Bastow; Kuo-Hsiung Lee
Multidrug resistant cancer cells susceptibility to cytotoxic taxane diterpenes from Taxus yunnanensis and Taxus chinensis.
Bioorganic & medicinal chemistry letters 2002;12(19):2785-8.
2002: Prapai Wongsinkongman; Arnold Brossi; Hui-Kang Wang; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents. Part 209: Pheophorbide-a derivatives as photo-Independent cytotoxic agents.
Bioorganic & medicinal chemistry 2002;10(3):583-91.
2002: Kenichiro Hayashi; Yuka Nakanishi; Kenneth F Bastow; Gordon Cragg; Hiroshi Nozaki; Kuo-Hsiung Lee
Antitumor agents. Part 212. Bucidarasins A-C, three new cytotoxic clerodane diterpenes from Bucida buceras.
Bioorganic & medicinal chemistry letters 2002;12(3):345-8.
2002: Pannarat Akanitapichat; Kenneth F Bastow
The antiviral agent 5-chloro-1,3-dihydroxyacridone interferes with assembly and maturation of herpes simplex virus.
Antiviral research 2002;53(2):113-26.
2001: Qian Shi; Hui-Kang Wang; Kenneth F Bastow; Y Tachibana; K Chen; F Y Lee; Kuo-Hsiung Lee
Antitumor agents 210. Synthesis and evaluation of taxoid-epipodophyllotoxin conjugates as novel cytotoxic agents.
Bioorganic & medicinal chemistry 2001;9(11):2999-3004.
2001: Kinuko Iwasa; Masataka Moriyasu; Y Tachibana; H S Kim; Y Wataya; Wolfgang Wiegrebe; Kenneth F Bastow; L Mark Cosentino; Mutsuo Kozuka; Kuo-Hsiung Lee
Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents.
Bioorganic & medicinal chemistry 2001;9(11):2871-84.
2001: Y Na; V S Li; Y Nakanishi; Kenneth F Bastow; Harold Kohn
Synthesis, DNA cross-linking activity, and cytotoxicity of dimeric mitomycins.
Journal of medicinal chemistry 2001;44(21):3453-62.
2001: H H Cheng; Hui-Kang Wang; J Ito; Kenneth F Bastow; Y Tachibana; Y Nakanishi; Z Xu; T Y Luo; Kuo-Hsiung Lee
Cytotoxic pheophorbide-related compounds from Clerodendrum calamitosum and C. cyrtophyllum.
Journal of natural products 2001;64(7):915-9.
2001: Lallan Mishra; R Sinha; Hideji Itokawa; Kenneth F Bastow; Y Tachibana; Y Nakanishi; N Kilgore; Kuo-Hsiung Lee
Anti-HIV and cytotoxic activities of Ru(II)/Ru(III) polypyridyl complexes containing 2,6-(2'-benzimidazolyl)-pyridine/chalcone as co-ligand.
Bioorganic & medicinal chemistry 2001;9(7):1667-71.
2001: Yi Xia; Zheng-Yu Yang; M J Hour; Sheng-Chu Kuo; Peng Xia; Kenneth F Bastow; Yuka Nakanishi; P Namrpoothiri; T Hackl; Ernest Hamel; H K Lee
Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones.
Bioorganic & medicinal chemistry letters 2001;11(9):1193-6.
2001: D S VanVliet; Y Tachibana; Kenneth F Bastow; Eng-Shang Huang; Kuo-Hsiung Lee
Antitumor agents. 207. Design, synthesis, and biological testing of 4beta-anilino-2-fluoro-4'-demethylpodophyllotoxin analogues as cytotoxic and antiviral agents.
Journal of medicinal chemistry 2001;44(9):1422-8.
2001: P Krishnan; Kenneth F Bastow
Novel mechanism of cellular DNA topoisomerase II inhibition by the pyranonaphthoquinone derivatives alpha-lapachone and beta-lapachone.
Cancer chemotherapy and pharmacology 2001;47(3):187-98.
2000: Z Xu; Fang-Rong Chang; Hui-Kang Wang; Yoshiki Kashiwada; Andrew T McPhail; Kenneth F Bastow; Y Tachibana; M Cosentino; Kuo-Hsiung Lee
Anti-HIV agents 45(1) and antitumor agents 205.(2) two new sesquiterpenes, leitneridanins A and B, and the cytotoxic and anti-HIV principles from Leitneria floridana.
Journal of natural products 2000;63(12):1712-5.
2000: Mann-Jen Hour; Li-Jiau Huang; Sheng-Chu Kuo; Y Xia; Kenneth F Bastow; Y Nakanishi; E Hamel; Kuo-Hsiung Lee
6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry 2000;43(23):4479-87.
2000: P Krishnan; Kenneth F Bastow
Novel mechanisms of DNA topoisomerase II inhibition by pyranonaphthoquinone derivatives-eleutherin, alpha lapachone, and beta lapachone.
Biochemical pharmacology 2000;60(9):1367-79.
2000: Masao Fukushima; Narihiko Fukamiya; Masayoshi Okano; Tatsuo Nehira; Kiyoshi Tagahara; Shun-Xiang Zhang; De-Cheng Zhang; Y Tachibana; Kenneth F Bastow; Kuo-Hsiung Lee
Cytotoxity of non-alkaloidal taxane diterpenes from Taxus chinensis against a paclitaxel-resistant cell line.
Cancer letters 2000;158(2):151-4.
2000: P Krishnan; Kenneth F Bastow
The 9-position in berberine analogs is an important determinant of DNA topoisomerase II inhibition.
Anti-cancer drug design 2000;15(4):255-64.
2000: Masataka Itoigawa; Yoshiki Kashiwada; C Ito; H Furukawa; Y Tachibana; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
Journal of natural products 2000;63(7):893-7.
2000: Yi Xia; Zheng-Yu Yang; Peng Xia; Kenneth F Bastow; Yuka Nakanishi; Kuo-Hsiung Lee
Antitumor agents. Part 202: novel 2'-amino chalcones: design, synthesis and biological evaluation.
Bioorganic & medicinal chemistry letters 2000;10(8):699-701.
2000: J Y Chang; X Guo; H X Chen; Z Jiang; Qin Fu; H K Wang; Kenneth F Bastow; Xiao-Kang Zhu; Jian Guan; Kuo-Hsiung Lee; Yung-Chi Cheng
Unique biochemical, cytotoxic, and antitumor activity of camptothecin and 4beta-amino-4'-O-demethylepipodophyllotoxin conjugates.
Biochemical pharmacology 2000;59(5):497-508.
2000: Pannarat Akanitapichat; Christopher T Lowden; Kenneth F Bastow
1,3-Dihydroxyacridone derivatives as inhibitors of herpes virus replication.
Antiviral research 2000;45(2):123-34.
2000: Y Tachibana; Xiao-Kang Zhu; P Krishnan; Kuo-Hsiung Lee; Kenneth F Bastow
Characterization of human lung cancer cells resistant to 4'-O-demethyl-4beta-(2"-nitro-4"-fluoroanilino)-4-desoxypodophyllotoxin , a unique compound in the epipodophyllotoxin antitumor class.
Anti-cancer drugs 2000;11(1):19-28.
1999: Junko Ishida; Hui-Kang Wang; Kenneth F Bastow; CQ Hu; Kuo-Hsiung Lee
Antitumor agents 201. Cytotoxicity of harmine and beta-carboline analogs.
Bioorganic & medicinal chemistry letters 1999;9(23):3319-24.
1999: M Ohyama; T Tanaka; T Ito; M Iinuma; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives.
Bioorganic & medicinal chemistry letters 1999;9(20):3057-60.
1999: S X Zhang; Kenneth F Bastow; Y Tachibana; Sheng-Chu Kuo; Ernest Hamel; Anthony B Mauger; V L Narayanan; Kuo-Hsiung Lee
Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry 1999;42(20):4081-7.
1999: John R Vance; Kenneth F Bastow
Inhibition of DNA topoisomerase II catalytic activity by the antiviral agents 7-chloro-1,3-dihydroxyacridone and 1,3,7-trihydroxyacridone.
Biochemical pharmacology 1999;58(4):703-8.
1999: Xiao-Kang Zhu; Jian Guan; Y Tachibana; Kenneth F Bastow; S J Cho; H H Cheng; Yung-Chi Cheng; M Gurwith; Kuo-Hsiung Lee
Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles.
Journal of medicinal chemistry 1999;42(13):2441-6.
1999: Zheng-Yu Yang; Yi Xia; Peng Xia; Y Tachibana; Kenneth F Bastow; Kuo-Hsiung Lee
Antitumor agents 187: synthesis and cytotoxicity of substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-one and related compounds.
Bioorganic & medicinal chemistry letters 1999;9(5):713-6.
1998: Jian Guan; Xiao-Kang Zhu; Y Tachibana; Kenneth F Bastow; Arnold Brossi; Ernest Hamel; Kuo-Hsiung Lee
Antitumor agents. Part 186: Synthesis and biological evaluation of demethylcolchiceinamide analogues as cytotoxic DNA topoisomerase II inhibitors.
Bioorganic & medicinal chemistry 1998;6(11):2127-31.
1998: Jian Guan; Xiao-Kang Zhu; Y Tachibana; Kenneth F Bastow; Arnold Brossi; Ernest Hamel; Kuo-Hsiung Lee
Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.
Journal of medicinal chemistry 1998;41(11):1956-61.
1998: MC Miller; Kenneth F Bastow; C N Stineman; John R Vance; S C Song; DX West; Iris H Hall
The cytotoxicity of 2-formyl and 2-acetyl-(6-picolyl)-4N-substituted thiosemicarbazones and their copper(II) complexes.
Archiv der Pharmazie 1998;331(4):121-7.
1998: Yi Xia; Zheng-Yu Yang; Peng Xia; Kenneth F Bastow; Y Tachibana; Sheng-Chu Kuo; Ernest Hamel; T Hackl; Kuo-Hsiung Lee
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
Journal of medicinal chemistry 1998;41(7):1155-62.
1997: Kenneth F Bastow; H K Wang; Yung-Chi Cheng; Kuo-Hsiung Lee
Antitumor agents--CLXXIII. Synthesis and evaluation of camptothecin-4 beta-amino-4'-O-demethyl epipodophyllotoxin conjugates as inhibitors of mammalian DNA topoisomerases and as cytotoxic agents.
Bioorganic & medicinal chemistry 1997;5(8):1481-8.
1997: Barry Goz; Kenneth F Bastow
A possible role for topoisomerase II in cell death and N-phosphonoacetyl-L-aspartate-resistance frequency and its enhancement by 1-beta-D-arabinofuranosyl cytosine and 5-fluoro-2'-deoxyuridine.
Mutation research 1997;384(2):89-106.
1997: MC Miller; A Sood; BF Spielvogel; Kenneth F Bastow; Iris H Hall
Cytotoxic action of carboxyborane heterocyclic amine adducts.
Metal-based drugs 1997;4(4):229-41.
1996: X Chen; Kenneth F Bastow; Barry Goz; Louis S Kucera; Susan L Morris-Natschke; K S Ishaq
Synthesis and evaluation of novel thymidine analogs as antitumor and antiviral agents.
Journal of medicinal chemistry 1996;39(17):3412-7.
1996: Hui-Kang Wang; Kenneth F Bastow; L Mark Cosentino; Kuo-Hsiung Lee
Antitumor agents. 166. Synthesis and biological evaluation of 5,6,7,8-substituted-2-phenylthiochromen-4-ones.
Journal of medicinal chemistry 1996;39(10):1975-80.
1996: SJ Cho; Yoshiki Kashiwada; Kenneth F Bastow; Yung-Chi Cheng; Kuo-Hsiung Lee
Antitumor agents. 164. Podophenazine, 2'',3''-dichloropodophenazine, benzopodophenazine, and their 4 beta-p-nitroaniline derivatives as novel DNA topoisomerase II inhibitors.
Journal of medicinal chemistry 1996;39(7):1396-402.
1994: Kenneth F Bastow; M Itoigawa; H Furukawa; Yoshiki Kashiwada; I D Bori; L M Ballas; Kuo-Hsiung Lee
Antiproliferative actions of 7-substituted 1,3-dihydroxyacridones; possible involvement of DNA topoisomerase II and protein kinase C as biochemical targets.
Bioorganic & medicinal chemistry 1994;2(12):1403-11.
1994: A Sood; BF Spielvogel; W J Powell; Kenneth F Bastow; M C Miller; Iris H Hall
Cytotoxicity of ribo-and arabinoside boron nucleosides in tissue culture cells.
Anticancer research 1994;14(4A):1483-8.
1993: Kenneth F Bastow; H Tatematsu; L Sun; Y Fukushima; Kuo-Hsiung Lee
Synthesis and biological evaluation of tetrademethyl isocolchicine derivatives as inhibitors of DNA topoisomerase action in vitro.
Bioorganic & medicinal chemistry 1993;1(3):227-34.
1993: Kenneth F Bastow; I D Bori; Y Fukushima; Yoshiki Kashiwada; T Tanaka; G Nonaka; I Nishioka; Kuo-Hsiung Lee
Inhibition of DNA topoisomerases by sanguiin H-6, a cytotoxic dimeric ellagitannin from Sanguisorba officinalis.
Planta medica 1993;59(3):240-5.
1993: Yoshiki Kashiwada; G Nonaka; I Nishioka; K J Lee; I Bori; Y Fukushima; Kenneth F Bastow; Kuo-Hsiung Lee
Tannins as potent inhibitors of DNA topoisomerase II in vitro.
Journal of pharmaceutical sciences 1993;82(5):487-92.
1989: Kenneth F Bastow; B S Zhou; Yung-Chi Cheng
Human topoisomerase 1 messenger RNA is not destabilized by the herpes simplex virus type 2 virion-associated shut-off function.
Virus genes 1989;2(4):357-65.
1989: B S Zhou; Kenneth F Bastow; Yung-Chi Cheng
Characterization of the 3' region of the human DNA topoisomerase I gene.
Cancer research 1989;49(14):3922-7.
1988: J S Gibbs; H C Chiou; Kenneth F Bastow; Y C Cheng; Donald M Coen
Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6672-6.
1987: Yung-Chi Cheng; Ginger E Dutschman; Kenneth F Bastow; M G Sarngadharan; R Y Ting
Human immunodeficiency virus reverse transcriptase. General properties and its interactions with nucleoside triphosphate analogs.
The Journal of biological chemistry 1987;262(5):2187-9.
1986: Kenneth F Bastow; J Bouchard; X J Ren; Y C Cheng
Synthesis of dihydrofolate reductase and metabolism of related RNA in a methotrexate resistant human cell line infected with herpes simplex virus type 2.
Virology 1986;149(2):199-207.
1985: J Bouchard; Kenneth F Bastow; M C Starnes; R Prabhu; Y C Cheng
Characterization of dihydrofolate reductase-related DNA and RNA from human KB cell subclones containing different amounts of enzyme.
Cancer research 1985;45(4):1717-22.
1984: K B Frank; D D Derse; Kenneth F Bastow; Yung-Chi Cheng
Novel interaction of aphidicolin with herpes simplex virus DNA polymerase and polymerase-associated exonuclease.
The Journal of biological chemistry 1984;259(21):13282-6.
1984: Yung-Chi Cheng; S P Grill; Ginger E Dutschman; K B Frank; J F Chiou; Kenneth F Bastow; K Nakayama
Effects of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new antiherpesvirus compound, on synthesis of macromolecules in herpes simplex virus-infected cells.
Antimicrobial agents and chemotherapy 1984;26(3):283-8.
1984: Kenneth F Bastow; R Prabhu; Y C Cheng
The intracellular content of dihydrofolate reductase: possibilities for control and implications for chemotherapy.
Advances in enzyme regulation 1984;22():15-26.
1983: Yung-Chi Cheng; S P Grill; Ginger E Dutschman; K Nakayama; Kenneth F Bastow
Metabolism of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new anti-herpes virus compound, in herpes simplex virus-infected cells.
The Journal of biological chemistry 1983;258(20):12460-4.
1983: Kenneth F Bastow; D D Derse; Yung-Chi Cheng
Susceptibility of phosphonoformic acid-resistant herpes simplex virus variants to arabinosylnucleosides and aphidicolin.
Antimicrobial agents and chemotherapy 1983;23(6):914-7.
1982: D Derse; Kenneth F Bastow; Y Cheng
Characterization of the DNA polymerases induced by a group of herpes simplex virus type I variants selected for growth in the presence of phosphonoformic acid.
The Journal of biological chemistry 1982;257(17):10251-60.
1982: B A Domin; S P Grill; Kenneth F Bastow; Yung-Chi Cheng
Effect of methotrexate on dihydrofolate reductase activity in methotrexate-resistant human KB cells.
Molecular pharmacology 1982;21(2):478-82.
1982: A Minson; S E Bell; Kenneth F Bastow
Correlation of the virus sequence content and biological properties of cells carrying the herpes simplex virus type 2 thymidine kinase gene.
The Journal of general virology 1982;58 Pt 1():127-38.
1980: G Darby; Brendan Larder; Kenneth F Bastow; H J Field
Sensitivity of viruses to phosphorylated 9-(2-hydroxyethoxymethyl)guanine revealed in TK-transformed cells.
The Journal of general virology 1980;48(Pt 2):451-4.