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Kenneth Bastow
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83
Lee, Kuo-Hsiung
14
Nakagawa-Goto, Kyoko
13
Nakanishi, Yuka
12
Tachibana, Y
11
Morris-Natschke, Susan
10
Brossi, Arnold
9
Wu, Tian-Shung
8
Wang, Hui-Kang
8
Chang, Fang-Rong
8
Hamel, Ernest
6
Kashiwada, Yoshiki
6
Cragg, Gordon
6
Kuo, Sheng-Chu
6
Su, Chung-Ren
5
Vance, John
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All Publications
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2009: Dong Yizhou; Shi Qian; Nakagawa-Goto Kyoko; Wu Pei-Chi; Bastow Kenneth F; Morris-Natschke Susan L; Lee Kuo-Hsiung
Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.
Bioorganic & medicinal chemistry letters 2009;19(22):6289-92.
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2009: Su Chung-Ren; Yeh Sheau Farn; Liu Chih Miem; Damu Amooru G; Kuo Tsung-Hsiao; Chiang Po-Cheng; Bastow Kenneth F; Lee Kuo-Hsiung; Wu Tian-Shung
Anti-HBV and cytotoxic activities of pyranocoumarin derivatives.
Bioorganic & medicinal chemistry 2009;17(16):6137-43.
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2009: Dong Yizhou; Shi Qian; Liu Yi-Nan; Wang Xiang; Bastow Kenneth F; Lee Kuo-Hsiung
Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents.
Journal of medicinal chemistry 2009;52(11):3586-90.
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2008: Wu Gang; Guo Huan-Fang; Gao Kun; Liu Yi-Nan; Bastow Kenneth F; Morris-Natschke Susan L; Lee Kuo-Hsiung; Xie Lan
Synthesis of unsymmetrical biphenyls as potent cytotoxic agents.
Bioorganic & medicinal chemistry letters 2008;18(19):5272-6.
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2008: Lee Chia-Lin; Nakagawa-Goto Kyoko; Yu Donglei; Liu Yi-Nan; Bastow Kenneth F; Morris-Natschke Susan L; Chang Fang-Rong; Wu Yang-Chang; Lee Kuo-Hsiung
Cytotoxic calanquinone A from Calanthe arisanensis and its first total synthesis.
Bioorganic & medicinal chemistry letters 2008;18(15):4275-7.
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2008: Reddy M Vijaya Bhaskar; Su Chung-Ren; Chiou Wen-Fei; Liu Yi-Nan; Chen Rosemary Yin-Hwa; Bastow Kenneth F; Lee Kuo-Hsiung; Wu Tian-Shung
Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents.
Bioorganic & medicinal chemistry 2008;16(15):7358-70.
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2008: Nakagawa-Goto Kyoko; Bastow Kenneth F; Chen Tzu-Hsuan; Morris-Natschke Susan L; Lee Kuo-Hsiung
Antitumor agents 260. New desmosdumotin B analogues with improved in vitro anticancer activity.
Journal of medicinal chemistry 2008;51(11):3297-303.
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2008: Su Chung-Ren; Damu Amooru G; Chiang Po-Cheng; Bastow Kenneth F; Morris-Natschke Susan L; Lee Kuo-Hsiung; Wu Tian-Shung
Total synthesis of phenanthroindolizidine alkaloids (+/-)-antofine, (+/-)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity.
Bioorganic & medicinal chemistry 2008;16(11):6233-41.
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2008: Peng Chieh-Yu; Pan Shiow-Lin; Lee Kuo-Hsiung; Bastow Kenneth F; Teng Che-Ming
Molecular mechanism of the inhibitory effect of KS-5 on bFGF-induced angiogenesis in vitro and in vivo.
Cancer letters 2008;263(1):114-21.
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2008: Usami Yoshihide; Liu Yi-Nan; Lin An-Shen; Shibano Makio; Akiyama Toshiyuki; Itokawa Hideji; Morris-Natschke Susan L; Bastow Kenneth; Kasai Ryoji; Lee Kuo-Hsiung
Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)H NMR spectra.
Journal of natural products 2008;71(3):478-81.
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2007: Nakagawa-Goto Kyoko; Yamada Koji; Nakamura Seikou; Chen Tzu-Hsuan; Chiang Po-Cheng; Bastow Kenneth F; Wang Shao-Chun; Spohn Bill; Hung Mien-Chie; Lee Fang-Yu; Lee Fang-Chen; Lee Kuo-Hsiung
Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant--taxoid conjugates as novel cytotoxic agents.
Bioorganic & medicinal chemistry letters 2007;17(18):5204-9.
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2007: Tatsuzaki Jin; Taniguchi Masahiko; Bastow Kenneth F; Nakagawa-Goto Kyoko; Morris-Natschke Susan L; Itokawa Hideji; Baba Kimiye; Lee Kuo-Hsiung
Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents.
Bioorganic & medicinal chemistry 2007;15(18):6193-9.
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2007: Zhou Li-Bo; Chen Tzu-Hsuan; Bastow Kenneth F; Shibano Makio; Lee Kuo-Hsiung; Chen Dao-Feng
Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus.
Journal of natural products 2007;70(8):1263-7.
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2007: Wei Linyi; Shi Qian; Bastow Kenneth F; Brossi Arnold; Morris-Natschke Susan L; Nakagawa-Goto Kyoko; Wu Tian-Shung; Pan Shiow-Lin; Teng Che-Ming; Lee Kuo-Hsiung
Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents.
Journal of medicinal chemistry 2007;50(15):3674-80.
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2007: Damu Amooru G; Kuo Ping-Chung; Su Chung-Ren; Kuo Tsung-Hsiao; Chen Tzu-Hsuan; Bastow Kenneth F; Lee Kuo-Hsiung; Wu Tian-Shung
Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata.
Journal of natural products 2007;70(7):1146-52.
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2007: Nakagawa-Goto Kyoko; Chen Tzu-Hsuan; Peng Chieh-Yu; Bastow Kenneth F; Wu Jiu-Hong; Lee Kuo-Hsiung
Antitumor agents 259. Design, syntheses, and structure-activity relationship study of desmosdumotin C analogs.
Journal of medicinal chemistry 2007;50(14):3354-8.
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2007: Nakagawa-Goto Kyoko; Nakamura Seikou; Bastow Kenneth F; Nyarko Alexander; Peng Chieh-Yu; Lee Fang-Yu; Lee Fang-Chen; Lee Kuo-Hsiung
Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents.
Bioorganic & medicinal chemistry letters 2007;17(10):2894-8.
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2007: Rosselli Sergio; Bruno Maurizio; Maggio Antonella; Bellone Gabriella; Chen Tzu-Hsuan; Bastow Kenneth F; Lee Kuo-Hsiung
Cytotoxic activity of some natural and synthetic ent-kauranes.
Journal of natural products 2007;70(3):347-52.
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2007: Zhang Shuxing; Wei Linyi; Bastow Ken; Zheng Weifan; Brossi Arnold; Lee Kuo-Hsiung; Tropsha Alexander
Antitumor agents 252. Application of validated QSAR models to database mining: discovery of novel tylophorine derivatives as potential anticancer agents.
Journal of computer-aided molecular design 2007;21(1-3):97-112.
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2006: Tatsuzaki Jin; Bastow Kenneth F; Nakagawa-Goto Kyoko; Nakamura Seiko; Itokawa Hideji; Lee Kuo-Hsiung
Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents.
Journal of natural products 2006;69(10):1445-9.
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2006: Wei Linyi; Brossi Arnold; Kendall Ross; Bastow Kenneth F; Morris-Natschke Susan L; Shi Qian; Lee Kuo-Hsiung
Antitumor agents 251: synthesis, cytotoxic evaluation, and structure-activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents.
Bioorganic & medicinal chemistry 2006;14(19):6560-9.
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2006: Horiuch Masafumi; Murakami Chihiro; Fukamiya Narihiko; Yu Donglei; Chen Tzu-Hsuan; Bastow Kenneth F; Zhang De-Cheng; Takaishi Yoshihisa; Imakura Yasuhiro; Lee Kuo-Hsiung
Tripfordines A-C, sesquiterpene pyridine alkaloids from Tripterygium wilfordii, and structure anti-HIV activity relationships of Tripterygium alkaloids.
Journal of natural products 2006;69(9):1271-4.
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2006: Wang Xihong; Nakagawa-Goto Kyoko; Bastow Kenneth F; Don Ming-Jaw; Lin Yun-Lian; Wu Tian-Shung; Lee Kuo-Hsiung
Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents.
Journal of medicinal chemistry 2006;49(18):5631-4.
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2006: Kuo Ping-Chung; Kuo Tsung-Hsiao; Damu Amooru G; Su Chung-Ren; Lee E-Jian; Wu Tian-Shung; Shu Rexen; Chen Chou-Ming; Bastow Kenneth F; Chen Tzu-Hsuan; Lee Kuo-Hsiung
Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata.
Organic letters 2006;8(14):2953-6.
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2006: Lin Li; Shi Qian; Nyarko Alexander K; Bastow Kenneth F; Wu Chin-Chung; Su Ching-Yuan; Shih Charles C-Y; Lee Kuo-Hsiung
Antitumor agents. 250. Design and synthesis of new curcumin analogues as potential anti-prostate cancer agents.
Journal of medicinal chemistry 2006;49(13):3963-72.
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2006: Sakurai Nobuko; Nakagawa-Goto Kyoko; Ito Junko; Sakurai Yojiro; Nakanishi Yuka; Bastow Kenneth F; Cragg Gordon; Lee Kuo-Hsiung
Cytotoxic Alangium alkaloids from Alangium longiflorum.
Phytochemistry 2006;67(9):894-7.
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2006: Akanitapichat Pannarat; Wangmaneerat Aree; Wilairat Prapon; Bastow Kenneth F
Anti-herpes virus activity of Dunbaria bella Prain.
Journal of ethnopharmacology 2006;105(1-2):64-8.
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2006: Sakurai Yojiro; Sakurai Nobuko; Taniguchi Masahiko; Nakanishi Yuka; Bastow Kenneth F; Wang Xihong; Cragg Gordon M; Lee Kuo-Hsiung
Rautandiols A and B, pterocarpans and cytotoxic constituents from Neorautanenia mitis.
Journal of natural products 2006;69(3):397-9.
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2005: Bruno Maurizio; Rosselli Sergio; Maggio Antonella; Raccuglia Rosa Angela; Bastow Kenneth F; Wu Chin-Chung; Lee Kuo-Hsiung
Cytotoxic activity of some natural and synthetic sesquiterpene lactones.
Planta medica 2005;71(12):1176-8.
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2005: Bruno Maurizio; Rosselli Sergio; Maggio Antonella; Raccuglia Rosa Angela; Bastow Kenneth F; Lee Kuo-Hsiung
Cytotoxic activity of some natural and synthetic guaianolides.
Journal of natural products 2005;68(7):1042-6.
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2005: Nakamura Seikou; Kozuka Mutsuo; Bastow Kenneth F; Tokuda Harukuni; Nishino Hoyoku; Suzuki Madoka; Tatsuzaki Jin; Morris Natschke Susan L; Kuo Sheng-Chu; Lee Kuo-Hsiung
Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters.
Bioorganic & medicinal chemistry 2005;13(14):4396-401.
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2005: Nakagawa-Goto Kyoko; Bastow Kenneth F; Wu Jiu-Hong; Tokuda Harukuni; Lee Kuo-Hsiung
Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs.
Bioorganic & medicinal chemistry letters 2005;15(12):3016-9.
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2005: Nakagawa-Goto Kyoko; Wu Jiu-Hong; Bastow Kenneth F; Wu Chin-Chung; Lee Kuo-Hsiung
Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives.
Bioorganic & medicinal chemistry 2005;13(6):2325-30.
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2005: Lai Ya-Yun; Huang Li-Jiau; Lee Kuo-Hsiung; Xiao Zhiyan; Bastow Kenneth F; Yamori Takao; Kuo Sheng-Chu
Synthesis and biological relationships of 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents.
Bioorganic & medicinal chemistry 2005;13(1):265-75.
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2005: Nakagawa-Goto Kyoko; Chen Cyril X; Hamel Ernest; Wu Chin-Chung; Bastow Kenneth F; Brossi Arnold; Lee Kuo-Hsiung
Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives.
Bioorganic & medicinal chemistry letters 2005;15(1):235-8.
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2004: Bastow K F
New acridone inhibitors of human herpes virus replication.
Current drug targets. Infectious disorders 2004;4(4):323-30.
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2004: Liaw Chih-Chuang; Chang Fang-Rong; Wu Yang-Chang; Wang Hui-Kang; Nakanishi Yuka; Bastow Kenneth F; Lee Kuo-Hsiung
Montacin and cis-montacin, two new cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona montana.
Journal of natural products 2004;67(11):1804-8.
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2004: Wang Xihong; Bastow Kenneth F; Sun Chang-Ming; Lin Yun-Lian; Yu Hsi-Jung; Don Ming-Jaw; Wu Tian-Shung; Nakamura Seikou; Lee Kuo-Hsiung
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
Journal of medicinal chemistry 2004;47(23):5816-9.
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2004: Liaw Chih-Chuang; Chang Fang-Rong; Wu Chin-Chung; Chen Shu-Li; Bastow Kenneth F; Hayashi Ken-ichiro; Nozaki Hiroshi; Lee Kuo-Hsiung; Wu Yang-Chang
Nine new cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana.
Planta medica 2004;70(10):948-59.
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2004: Xiao Zhiyan; Bastow Kenneth F; Vance John R; Sidwell Robert S; Wang Hui-Kang; Chen Ming S; Shi Qian; Lee Kuo-Hsiung
Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives.
Journal of medicinal chemistry 2004;47(21):5140-8.
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2004: Murakami Chihiro; Fukamiya Narihiko; Tamura Sadaaki; Okano Masayoshi; Bastow Kenneth F; Tokuda Harukuni; Mukainaka Teruo; Nishino Hoyoky; Lee Kuo-Hsiung
Multidrug-resistant cancer cell susceptibility to cytotoxic quassinoids, and cancer chemopreventive effects of quassinoids and canthin alkaloids.
Bioorganic & medicinal chemistry 2004;12(18):4963-8.
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2004: Hayashi Ken-ichiro; Chang Fang-Rong; Nakanishi Yuka; Bastow Kenneth F; Cragg Gordon; McPhail Andrew T; Nozaki Hiroshi; Lee Kuo-Hsiung
Antitumor agents. 233. Lantalucratins A-F, new cytotoxic naphthoquinones from Lantana involucrata.
Journal of natural products 2004;67(6):990-3.
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2004: Xiao Zhiyan; Vance John R; Bastow Kenneth F; Brossi Arnold; Wang Hui-Kang; Lee Kuo-Hsiung
Antitumor agents. Part 235: Novel 4'-ester etoposide analogues as potent DNA topoisomerase II inhibitors with improved therapeutic potential.
Bioorganic & medicinal chemistry 2004;12(12):3363-9.
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2004: Xiao Zhiyan; Bastow Kenneth F; Vance John R; Lee Kuo-Hsiung
Antitumor agents. Part 227: Studies on novel 4'-O-demethyl-epipodophyllotoxins as antitumor agents targeting topoisomerase II.
Bioorganic & medicinal chemistry 2004;12(12):3339-44.
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2004: Han Shiqing; Xiao Zhiyan; Bastow Kenneth F; Lee Kuo-Hsiung
Antitumor agents. Part 230: C4'-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(11):2979-82.
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2004: Wang Yong-Hong; Hou Ai-Jun; Chen Lei; Chen Dao-Feng; Sun Han-Dong; Zhao Qin-Shi; Bastow Kenneth F; Nakanish Yuka; Wang Xi-Hong; Lee Kuo-Hsiung
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
Journal of natural products 2004;67(5):757-61.
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2004: Xiao Zhiyan; Han Shiqing; Bastow Kenneth F; Lee Kuo-Hsiung
Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents.
Bioorganic & medicinal chemistry letters 2004;14(6):1581-4.
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2003: Chang Fang-Rong; Hayashi Ken-Ichiro; Chen I-Hsiao; Liaw Chih-Chuang; Bastow Kenneth F; Nakanishi Yuka; Nozaki Hiroshi; Cragg Gordon M; Wu Yang-Chang; Lee Kuo-Hsiung
Antitumor agents. 228. five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii.
Journal of natural products 2003;66(11):1416-20.
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2003: Lowden Christopher T; Bastow Kenneth F
Anti-herpes simplex virus activity of substituted 1-hydroxyacridones.
Journal of medicinal chemistry 2003;46(23):5015-20.
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2003: Kuo Ping-Chung; Shi Li-Shian; Damu Amooru G; Su Chung-Ren; Huang Chieh-Hung; Ke Chih-Huang; Wu Jin-Bin; Lin Ai-Jeng; Bastow Kenneth F; Lee Kuo-Hsiung; Wu Tian-Shung
Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia.
Journal of natural products 2003;66(10):1324-7.
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2003: Xia Yi; Yang Zheng-Yu; Xia Peng; Bastow Kenneth F; Nakanishi Yuka; Nampoothiri Priya; Hamel Ernest; Brossi Arnold; Lee Kuo-Hsiung
Antitumor agents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters.
Bioorganic & medicinal chemistry letters 2003;13(17):2891-3.
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2003: Lowden C T; Bastow K F
Cell culture replication of herpes simplex virus and, or human cytomegalovirus is inhibited by 3,7-dialkoxylated, 1-hydroxyacridone derivatives.
Antiviral research 2003;59(3):143-54.
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2003: Nakanishi Yuka; Chang Fang-Rong; Liaw Chih-Chuang; Wu Yang-Chang; Bastow Kenneth F; Lee Kuo-Hsiung
Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.
Journal of medicinal chemistry 2003;46(15):3185-8.
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2003: Wu Jiu Hong; Chang Fang Rong; Hayashi Ken ichiro; Shiraki Hiroaki; Liaw Chih Chuang; Nakanishi Yuka; Bastow Kenneth F; Yu Donglei; Chen Ih Sheng; Lee Kuo Hsiung
Antitumor agents. Part 218: Cappamensin A, a new In vitro anticancer principle, from Capparis sikkimensis.
Bioorganic & medicinal chemistry letters 2003;13(13):2223-5.
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2003: Ohtsu Hironori; Nakanishi Yuka; Bastow Kenneth F; Lee Fang-Yu; Lee Kuo Hsiung
Antitumor agents 216. Synthesis and evaluation of paclitaxel-camptothecin conjugates as novel cytotoxic agents.
Bioorganic & medicinal chemistry 2003;11(8):1851-7.
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2003: Zhang Qian; Chen Ying; Zheng Yun Qing; Xia Peng; Xia Yi; Yang Zheng Yu; Bastow Kenneth F; Morris-Natschke Susan L; Lee Kuo Hsiung
Synthesis and bioactivity of 4,10-dimethyl-pyridino[2,3-h]quinolin-2(1H)-one-9-carboxylic acid and its esters.
Bioorganic & medicinal chemistry 2003;11(6):1031-4.
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2003: Hayashi Ken-Ichiro; Nakanishi Yuka; Bastow Kenneth F; Cragg Gordon; Nozaki Hiroshi; Lee Kuo-Hsiung
Antitumor agents. 221.1 buceracidins A and B, two new flavanones from Bucida buceras.
Journal of natural products 2003;66(1):125-7.
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2002: Ishida Junko; Ohtsu Hironori; Tachibana Yoko; Nakanishi Yuka; Bastow Kenneth F; Nagai Masahiro; Wang Hui-Kang; Itokawa Hideji; Lee Kuo-Hsiung
Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents.
Bioorganic & medicinal chemistry 2002;10(11):3481-7.
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2002: Han Shiqing; Hamel Ernest; Bastow Kenneth F; McPhail Andrew T; Brossi Arnold; Lee Kuo-Hsiung
Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.
Bioorganic & medicinal chemistry letters 2002;12(20):2851-3.
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2002: Shinozaki Youichi; Fukamiya Narihiko; Uchiyama Chieko; Okano Masayoshi; Tagahara Kiyoshi; Bastow Kenneth F; Lee Kuo-Hsiung
Multidrug resistant cancer cells susceptibility to cytotoxic taxane diterpenes from Taxus yunnanensis and Taxus chinensis.
Bioorganic & medicinal chemistry letters 2002;12(19):2785-8.
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2002: Wongsinkongman Prapai; Brossi Arnold; Wang Hui-Kang; Bastow Kenneth F; Lee Kuo-Hsiung
Antitumor agents. Part 209: Pheophorbide-a derivatives as photo-Independent cytotoxic agents.
Bioorganic & medicinal chemistry 2002;10(3):583-91.
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2002: Hayashi Ken-ichiro; Nakanishi Yuka; Bastow Kenneth F; Cragg Gordon; Nozaki Hiroshi; Lee Kuo-Hsiung
Antitumor agents. Part 212. Bucidarasins A-C, three new cytotoxic clerodane diterpenes from Bucida buceras.
Bioorganic & medicinal chemistry letters 2002;12(3):345-8.
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2002: Akanitapichat P; Bastow K F
The antiviral agent 5-chloro-1,3-dihydroxyacridone interferes with assembly and maturation of herpes simplex virus.
Antiviral research 2002;53(2):113-26.
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2001: Shi Q; Wang H K; Bastow K F; Tachibana Y; Chen K; Lee F Y; Lee K H
Antitumor agents 210. Synthesis and evaluation of taxoid-epipodophyllotoxin conjugates as novel cytotoxic agents.
Bioorganic & medicinal chemistry 2001;9(11):2999-3004.
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2001: Iwasa K; Moriyasu M; Tachibana Y; Kim H S; Wataya Y; Wiegrebe W; Bastow K F; Cosentino L M; Kozuka M; Lee K H
Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents.
Bioorganic & medicinal chemistry 2001;9(11):2871-84.
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2001: Cheng H H; Wang H K; Ito J; Bastow K F; Tachibana Y; Nakanishi Y; Xu Z; Luo T Y; Lee K H
Cytotoxic pheophorbide-related compounds from Clerodendrum calamitosum and C. cyrtophyllum.
Journal of natural products 2001;64(7):915-9.
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2001: Xia Y; Yang Z Y; Hour M J; Kuo S C; Xia P; Bastow K F; Nakanishi Y; Namrpoothiri P; Hackl T; Hamel E; Lee H K
Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones.
Bioorganic & medicinal chemistry letters 2001;11(9):1193-6.
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2001: VanVliet D S; Tachibana Y; Bastow K F; Huang E S; Lee K H
Antitumor agents. 207. Design, synthesis, and biological testing of 4beta-anilino-2-fluoro-4'-demethylpodophyllotoxin analogues as cytotoxic and antiviral agents.
Journal of medicinal chemistry 2001;44(9):1422-8.
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2001: Krishnan P; Bastow K F
Novel mechanism of cellular DNA topoisomerase II inhibition by the pyranonaphthoquinone derivatives alpha-lapachone and beta-lapachone.
Cancer chemotherapy and pharmacology 2001;47(3):187-98.
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2000: Xu Z; Chang F R; Wang H K; Kashiwada Y; McPhail A T; Bastow K F; Tachibana Y; Cosentino M; Lee K H
Anti-HIV agents 45(1) and antitumor agents 205.(2) two new sesquiterpenes, leitneridanins A and B, and the cytotoxic and anti-HIV principles from Leitneria floridana.
Journal of natural products 2000;63(12):1712-5.
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2000: Hour M J; Huang L J; Kuo S C; Xia Y; Bastow K; Nakanishi Y; Hamel E; Lee K H
6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry 2000;43(23):4479-87.
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2000: Krishnan P; Bastow K F
Novel mechanisms of DNA topoisomerase II inhibition by pyranonaphthoquinone derivatives-eleutherin, alpha lapachone, and beta lapachone.
Biochemical pharmacology 2000;60(9):1367-79.
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2000: Fukushima M; Fukamiya N; Okano M; Nehira T; Tagahara K; Zhang S X; Zhang D C; Tachibana Y; Bastow K F; Lee K H
Cytotoxity of non-alkaloidal taxane diterpenes from Taxus chinensis against a paclitaxel-resistant cell line.
Cancer letters 2000;158(2):151-4.
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2000: Krishnan P; Bastow K F
The 9-position in berberine analogs is an important determinant of DNA topoisomerase II inhibition.
Anti-cancer drug design 2000;15(4):255-64.
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2000: Itoigawa M; Kashiwada Y; Ito C; Furukawa H; Tachibana Y; Bastow K F; Lee K H
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
Journal of natural products 2000;63(7):893-7.
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2000: Xia Y; Yang Z Y; Xia P; Bastow K F; Nakanishi Y; Lee K H
Antitumor agents. Part 202: novel 2'-amino chalcones: design, synthesis and biological evaluation.
Bioorganic & medicinal chemistry letters 2000;10(8):699-701.
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2000: Chang J Y; Guo X; Chen H X; Jiang Z; Fu Q; Wang H K; Bastow K F; Zhu X K; Guan J; Lee K H; Cheng Y C
Unique biochemical, cytotoxic, and antitumor activity of camptothecin and 4beta-amino-4'-O-demethylepipodophyllotoxin conjugates.
Biochemical pharmacology 2000;59(5):497-508.
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2000: Akanitapichat P; Lowden C T; Bastow K F
1,3-Dihydroxyacridone derivatives as inhibitors of herpes virus replication.
Antiviral research 2000;45(2):123-34.
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2000: Tachibana Y; Zhu X K; Krishnan P; Lee K H; Bastow K F
Characterization of human lung cancer cells resistant to 4'-O-demethyl-4beta-(2"-nitro-4"-fluoroanilino)-4-desoxypodophyllotoxin , a unique compound in the epipodophyllotoxin antitumor class.
Anti-cancer drugs 2000;11(1):19-28.
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1999: Ishida J; Wang H K; Bastow K F; Hu C Q; Lee K H
Antitumor agents 201. Cytotoxicity of harmine and beta-carboline analogs.
Bioorganic & medicinal chemistry letters 1999;9(23):3319-24.
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1999: Ohyama M; Tanaka T; Ito T; Iinuma M; Bastow K F; Lee K H
Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives.
Bioorganic & medicinal chemistry letters 1999;9(20):3057-60.
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1999: Zhang S X; Bastow K F; Tachibana Y; Kuo S C; Hamel E; Mauger A; Narayanan V L; Lee K H
Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry 1999;42(20):4081-7.
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1999: Vance J R; Bastow K F
Inhibition of DNA topoisomerase II catalytic activity by the antiviral agents 7-chloro-1,3-dihydroxyacridone and 1,3,7-trihydroxyacridone.
Biochemical pharmacology 1999;58(4):703-8.
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1999: Zhu X K; Guan J; Tachibana Y; Bastow K F; Cho S J; Cheng H H; Cheng Y C; Gurwith M; Lee K H
Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles.
Journal of medicinal chemistry 1999;42(13):2441-6.
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1999: Yang Z Y; Xia Y; Xia P; Tachibana Y; Bastow K F; Lee K H
Antitumor agents 187: synthesis and cytotoxicity of substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-one and related compounds.
Bioorganic & medicinal chemistry letters 1999;9(5):713-6.
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1998: Guan J; Zhu X K; Tachibana Y; Bastow K F; Brossi A; Hamel E; Lee K H
Antitumor agents. Part 186: Synthesis and biological evaluation of demethylcolchiceinamide analogues as cytotoxic DNA topoisomerase II inhibitors.
Bioorganic & medicinal chemistry 1998;6(11):2127-31.
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1998: Guan J; Zhu X K; Tachibana Y; Bastow K F; Brossi A; Hamel E; Lee K H
Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.
Journal of medicinal chemistry 1998;41(11):1956-61.
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1998: Miller M C; Bastow K F; Stineman C N; Vance J R; Song S C; West D X; Hall I H
The cytotoxicity of 2-formyl and 2-acetyl-(6-picolyl)-4N-substituted thiosemicarbazones and their copper(II) complexes.
Archiv der Pharmazie 1998;331(4):121-7.
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1998: Xia Y; Yang Z Y; Xia P; Bastow K F; Tachibana Y; Kuo S C; Hamel E; Hackl T; Lee K H
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
Journal of medicinal chemistry 1998;41(7):1155-62.
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1997: Bastow K F; Wang H K; Cheng Y C; Lee K H
Antitumor agents--CLXXIII. Synthesis and evaluation of camptothecin-4 beta-amino-4'-O-demethyl epipodophyllotoxin conjugates as inhibitors of mammalian DNA topoisomerases and as cytotoxic agents.
Bioorganic & medicinal chemistry 1997;5(8):1481-8.
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1997: Miller M C; Sood A; Spielvogel B F; Bastow K; Hall I H
Cytotoxic action of carboxyborane heterocyclic amine adducts.
Metal-based drugs 1997;4(4):229-41.
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1996: Wang H K; Bastow K F; Cosentino L M; Lee K H
Antitumor agents. 166. Synthesis and biological evaluation of 5,6,7,8-substituted-2-phenylthiochromen-4-ones.
Journal of medicinal chemistry 1996;39(10):1975-80.
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1996: Cho S J; Kashiwada Y; Bastow K F; Cheng Y C; Lee K H
Antitumor agents. 164. Podophenazine, 2'',3''-dichloropodophenazine, benzopodophenazine, and their 4 beta-p-nitroaniline derivatives as novel DNA topoisomerase II inhibitors.
Journal of medicinal chemistry 1996;39(7):1396-402.
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1994: Bastow K F; Itoigawa M; Furukawa H; Kashiwada Y; Bori I D; Ballas L M; Lee K H
Antiproliferative actions of 7-substituted 1,3-dihydroxyacridones; possible involvement of DNA topoisomerase II and protein kinase C as biochemical targets.
Bioorganic & medicinal chemistry 1994;2(12):1403-11.
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1993: Bastow K F; Tatematsu H; Sun L; Fukushima Y; Lee K H
Synthesis and biological evaluation of tetrademethyl isocolchicine derivatives as inhibitors of DNA topoisomerase action in vitro.
Bioorganic & medicinal chemistry 1993;1(3):227-34.
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1993: Bastow K F; Bori I D; Fukushima Y; Kashiwada Y; Tanaka T; Nonaka G; Nishioka I; Lee K H
Inhibition of DNA topoisomerases by sanguiin H-6, a cytotoxic dimeric ellagitannin from Sanguisorba officinalis.
Planta medica 1993;59(3):240-5.
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1993: Kashiwada Y; Nonaka G; Nishioka I; Lee K J; Bori I; Fukushima Y; Bastow K F; Lee K H
Tannins as potent inhibitors of DNA topoisomerase II in vitro.
Journal of pharmaceutical sciences 1993;82(5):487-92.
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