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Pavel Martasek

Research Profile

Chemicals & Drugs

Disorders

Acute Intermittent Porphyria

Physiology

Mutation

Concepts & Ideas

Procedures

Living Beings

Anatomy

Neurons

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Czech Republic

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Publications

TOP 3
V Vobruba; Ivan Mikula; Pavla Pokorna; Olga Brantova; Olga Cerna; Jan Hridel; Oxana V Klimenko; Jiri Kobr; Pavel Martasek
Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1β proteins in pigs.
Tomas Kovarnik; Ales Kral; Lubomir Kralik; Michael Aschermann; Jan Belohlavek; Hana Benakova; Lenka Cernohousova; Martin Chval; Richard W Downe; Jan Horak; Pavel Martasek; Gary S Mintz; Hana Skalicka; Lenka Skalicka; Milan Sonka; Jana Uhrova; Andreas Wahle; Ales Linhart
The prediction of coronary artery disease based on non-invasive examinations and heme oxygenase 1 polymorphism versus virtual histology.
Radan Bruha; Martin Haluzik; Alena Jiraskova; Ivana Malikova; Zdenek Marecek; Pavel Martasek; Sona Nevsimalova; Jaromir Petrtyl; Lenka Pospisilova; Petr Urbanek; Libor Vitek; Peter Ferenci
Decreased serum antioxidant capacity in patients with Wilson disease is associated with neurological symptoms.

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All Publications

2013: V Vobruba; Ivan Mikula; Pavla Pokorna; Olga Brantova; Olga Cerna; Jan Hridel; Oxana V Klimenko; Jiri Kobr; Pavel Martasek
Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1β proteins in pigs.
Experimental lung research 2013;39(1):1-8.
2013: Tomas Kovarnik; Ales Kral; Lubomir Kralik; Michael Aschermann; Jan Belohlavek; Hana Benakova; Lenka Cernohousova; Martin Chval; Richard W Downe; Jan Horak; Pavel Martasek; Gary S Mintz; Hana Skalicka; Lenka Skalicka; Milan Sonka; Jana Uhrova; Andreas Wahle; Ales Linhart
The prediction of coronary artery disease based on non-invasive examinations and heme oxygenase 1 polymorphism versus virtual histology.
The Journal of invasive cardiology 2013;25(1):32-7.
2012: Radan Bruha; Martin Haluzik; Alena Jiraskova; Ivana Malikova; Zdenek Marecek; Pavel Martasek; Sona Nevsimalova; Jaromir Petrtyl; Lenka Pospisilova; Petr Urbanek; Libor Vitek; Peter Ferenci
Decreased serum antioxidant capacity in patients with Wilson disease is associated with neurological symptoms.
Journal of inherited metabolic disease 2012;35(3):541-8.
2011: Mateusz Kolanczyk; Markus Pech; Tomasz Zemojtel; Hiroshi Yamamoto; Ivan Mikula; Maria-Antonietta Calvaruso; Mariël van den Brand; Ricarda Richter; Bjoern Fischer; Anita Ritz; Nadine Kossler; Boris Thurisch; Ralf Spoerle; jan smeitink; Uwe Kornak; Danny Chan; Martin Vingron; Pavel Martasek; Robert N Lightowlers; Leo G J Nijtmans; Markus Schuelke; Knud H Nierhaus; Stefan Mundlos
NOA1 is an essential GTPase required for mitochondrial protein synthesis.
Molecular biology of the cell 2011;22(1):1-11.
2011: Radan Bruha; Zdenek Marecek; Lenka Pospisilova; Sona Nevsimalova; Libor Vitek; Pavel Martasek; Jiri Nevoral; Jaromir Petrtyl; Petr Urbanek; Alena Jiraskova; Peter Ferenci
Long-term follow-up of Wilson disease: natural history, treatment, mutations analysis and phenotypic correlation.
Liver international : official journal of the International Association for the Study of the Liver 2011;31(1):83-91.
2010: Angela Burgess; Ming Li; Luca Vanella; Dong Hyun Kim; Rita Rezzani; Luigi Fabrizio Rodella; Komal Sodhi; Martina Canestraro; Pavel Martasek; Stephen J Peterson; Attallah Kappas; Nader G Abraham
Adipocyte heme oxygenase-1 induction attenuates metabolic syndrome in both male and female obese mice.
Hypertension 2010;56(6):1124-30.
2010: Dana Douderova; Xiaoye Schneider-Yin; Stephan Lautenschlager; Vladimir Saudek; Martin Theiler; Günther Hofbauer; Piotr J Dziunycz; Noritaka Oyama; Lars E French; Pavel Martasek; Elisabeth I Minder
Lichen sclerosus et atrophicus-like skin lesions in a patient carrying a novel hydroxymethylbilane synthase mutation.
Blood cells, molecules & diseases 2010;45(2):176-9.
2010: Dana Ulbrichova Douderova; Jiri Zeman; Pavel Martasek
Novel human pathological mutations. Gene symbol: HMBS. Disease: porphyria, acute intermittent.
Human genetics 2010;127(4):477.
2010: Oxana V Klimenko; Vaclav Vobruba; Pavel Martasek
Influence of the lung mechanical ventilation with injurious parameters on 7-ketocholesterol synthesis in Sus Scrofa.
BMB reports 2010;43(4):257-62.
2010: Daniela Zahorakova; Olga Ulmanova; David Kemlink; Marie Kofrankova; Jan Roth; Pavel Martasek; Evzen Ruzicka
No association with the ETM2 locus in Czech patients with familial essential tremor.
Neuro endocrinology letters 2010;31(4):549-52.
2010: Ondrej Fiala; Lenka Pospisilova; Jana Prochazkova; Milada Matejckova; Pavel Martasek; Lucie Novakova; Jan Roth; Evzen Ruzicka
Parkin mutations and phenotypic features in Czech patients with early-onset Parkinson's disease.
Neuro endocrinology letters 2010;31(2):187-92.
2010: Dana Ulbrichova Douderova; Rivka Mamet; Gabriel Munter; Pavel Martasek; Nili Schoenfeld
Novel human pathological mutations. Gene symbol: HMBS. Disease: Acute intermittent porphyria.
Human genetics 2010;127(1):114.
2009: Dana Ulbrichova-Douderova; Pavel Martasek
Detection of DNA variations in the polymorphic hydroxymethylbilane synthase gene by high-resolution melting analysis.
Analytical biochemistry 2009;395(1):41-8.
2009: Dana Ulbrichova Douderova; Matous Hrdinka; Vladimir Saudek; Pavel Martasek
Acute intermittent porphyria--impact of mutations found in the hydroxymethylbilane synthase gene on biochemical and enzymatic protein properties.
The FEBS journal 2009;276(7):2106-15.
2009: Ivan Mikula; Suzanne Durocher; Pavel Martasek; Bulent Mutus; Anny SLAMA-SCHWOK
Isoform-specific differences in the nitrite reductase activity of nitric oxide synthases under hypoxia.
The Biochemical journal 2009;418(3):673-82.
2009: Edward Beaumont; Jean-Christophe Lambry; Mireille Blanchard-Desce; Pavel Martasek; Satya P Panda; Ernst E H van Faassen; Jean-Claude Brochon; Eric Deprez; Anny SLAMA-SCHWOK
NO formation by neuronal NO-synthase can be controlled by ultrafast electron injection from a nanotrigger.
Chembiochem : a European journal of chemical biology 2009;10(4):690-701.
2009: Dana Ulbrichova Douderova; Xiaoye Schneider-Yin; Rivka Mamet; Vladimir Saudek; Pavel Martasek; Elisabeth I Minder; Nili Schoenfeld
Correlation between biochemical findings, structural and enzymatic abnormalities in mutated HMBS identified in six Israeli families with acute intermittent porphyria.
Blood cells, molecules & diseases 2009;42(2):167-73.
2009: Lenka Slachtova; David Kemlink; Pavel Martasek; P Kabicek
Does bilirubin level correspond to interaction of c.-3279T>G and A(TA)7TAA variants in UGT1A1 gene?
Cellular and molecular biology (Noisy-le-Grand, France) 2009;55(1):98-101.
2008: Edward Beaumont; Jean-Christophe Lambry; Anne-Claire Robin; Pavel Martasek; Mireille Blanchard-Desce; Anny SLAMA-SCHWOK
Two photon-induced electron injection from a nanotrigger in native endothelial NO-synthase.
Chemphyschem : a European journal of chemical physics and physical chemistry 2008;9(16):2325-31.
2008: Daniela Zahorakova; Vera Jüttnerova; Jiri Zeman; Pavel Martasek
Gene symbol: MECP2. Disease: Rett syndrome.
Human genetics 2008;124(3):315.
2008: Dana Ulbrichova Douderova; Ismail Kurt; Jiri Zeman; Pavel Martasek
Gene symbol: HMBS. Disease: Porphyria, acute intermittent.
Human genetics 2008;124(3):315.
2008: Xiaoye Schneider-Yin; Dana Ulbrichova Douderova; Rivka Mamet; Pavel Martasek; Christopher C Marohnic; Avner Tzvi Goren; Elisabeth I Minder; Nili Schoenfeld
Characterization of two missense variants in the hydroxymethylbilane synthase gene in the Israeli population, which differ in their associations with acute intermittent porphyria.
Molecular genetics and metabolism 2008;94(3):343-6.
2007: Jiwon Seo; Jotato Igarashi; Huiying Li; Pavel Martasek; Linda Roman; Thomas L Poulos; Richard B Silverman
Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water.
Journal of medicinal chemistry 2007;50(9):2089-99.
2007: Daniela Zahorakova; Robert Rosipal; Jan Hadac; Alena Zumrova; Vladimir Bzduch; Nadezda Misovicova; Alice Baxova; Jirí Zeman; Pavel Martasek
Mutation analysis of the MECP2 gene in patients of Slavic origin with Rett syndrome: novel mutations and polymorphisms.
Journal of human genetics 2007;52(4):342-8.
2006: Isabelle Salard; Emilie Mercey; Eleni A Rekka; Jean-Luc Boucher; Pierre Nioche; Ivan Mikula; Pavel Martasek; C.S. Raman; Daniel Mansuy
Analogies and surprising differences between recombinant nitric oxide synthase-like proteins from Staphylococcus aureus and Bacillus anthracis in their interactions with l-arginine analogs and iron ligands.
Journal of inorganic biochemistry 2006;100(12):2024-33.
2006: Clément Gautier; Ivan Mikula; Pierre Nioche; Pavel Martasek; C.S. Raman; Anny SLAMA-SCHWOK
Dynamics of NO rebinding to the heme domain of NO synthase-like proteins from bacterial pathogens.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2006;15(4):312-27.
2006: Tomasz Zemojtel; Andreas Fröhlich; M Cristina Palmieri; Mateusz Kolanczyk; Ivan Mikula; Lucjan S Wyrwicz; Erich E Wanker; Stefan Mundlos; Martin Vingron; Pavel Martasek; Jörg Durner
Plant nitric oxide synthase: a never-ending story?
Trends in plant science 2006;11(11):524-5; author reply 526-8.
2006: Haitao Ji; José A Gómez-Vidal; Pavel Martasek; Linda Roman; Richard B Silverman
Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors.
Journal of medicinal chemistry 2006;49(21):6254-63.
2006: Clément Gautier; Ernst E van Faassen; Ivan Mikula; Pavel Martasek; Anny SLAMA-SCHWOK
Endothelial nitric oxide synthase reduces nitrite anions to NO under anoxia.
Biochemical and biophysical research communications 2006;341(3):816-21.
2006: Tomasz Zemojtel; Mateusz Kolanczyk; Nadine Kossler; Sigmar Stricker; Rudi Lurz; Ivan Mikula; Marlena Duchniewicz; Markus Schuelke; Pedram Ghafourifar; Pavel Martasek; Martin Vingron; Stefan Mundlos
Mammalian mitochondrial nitric oxide synthase: characterization of a novel candidate.
FEBS letters 2006;580(2):455-62.
2006: Jean-Charles Deybach; M Badminton; Hervé Puy; Sverre Sandberg; J Frank; P Harper; Pavel Martasek; Elisabeth I Minder; S Parker; S Thunell; G Elder
European porphyria initiative (EPI): a platform to develop a common approach to the management of porphyrias and to promote research in the field.
Physiological research / Academia Scientiarum Bohemoslovaca 2006;55 Suppl 2():S67-73.
2006: Dana Ulbrichova Douderova; E Flachsova; Matous Hrdinka; J Saligova; J Bazar; C.S. Raman; Pavel Martasek
De Novo mutation found in the porphobilinogen deaminase gene in Slovak acute intermittent porphyria patient: molecular biochemical study.
Physiological research / Academia Scientiarum Bohemoslovaca 2006;55 Suppl 2():S145-54.
2006: Matous Hrdinka; Hervé Puy; Pavel Martasek
May 2006 update in porphobilinogen deaminase gene polymorphisms and mutations causing acute intermittent porphyria: comparison with the situation in Slavic population.
Physiological research / Academia Scientiarum Bohemoslovaca 2006;55 Suppl 2():S119-36.
2004: Katerina Vesela; Hana Hansikova; Marketa Tesarova; Pavel Martasek; Milan Elleder; Josef Houstek; Jirí Zeman
Clinical, biochemical and molecular analyses of six patients with isolated cytochrome c oxidase deficiency due to mutations in the SCO2 gene.
Acta paediatrica (Oslo, Norway : 1992) 2004;93(10):1312-7.
2004: Ying Tong Gao; Susan M E Smith; J Brice Weinberg; Heathr Montgomery; Elena Newman; J Guy Guillemette; Dipak K Ghosh; Linda Roman; Pavel Martasek; John Salerno
Thermodynamics of oxidation-reduction reactions in mammalian nitric-oxide synthase isoforms.
The Journal of biological chemistry 2004;279(18):18759-66.
2004: Vladimir Bzduch; D Zahorakova; E Grechanina; E P Zdibskaja; I G Goldfarb; Jirí Zeman; Pavel Martasek
A case of Rett syndrome from Ukraine--clinical diagnosis confirmed by mutation analysis of the MECP2 gene.
Bratislavské lekárske listy 2004;105(9):299-302.
2003: Satoshi Katsumoto; Susan M E Smith; Pavel Martasek; John Salerno
Competition and binding of arginine, imidazole, and aminoguanidine to endothelial nitric oxide synthase: aminoguanidine is a poor model for substrate, intermediate, and arginine analog inhibitor binding.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2003;8(3):149-54.
2002: Albert Huisman; Ingrid H Vos; Ernst E van Faassen; Jaap A Joles; Hermann-Josef Gröne; Pavel Martasek; Anton-Jan van Zonneveld; Anatoly F Vanin; ton rabelink
Anti-inflammatory effects of tetrahydrobiopterin on early rejection in renal allografts: modulation of inducible nitric oxide synthase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(9):1135-7.
2002: Ulrich Gross; Hervé Puy; Alexandra Kühnel; U Meissauer; Jean-Charles Deybach; Karl Jacob; Pavel Martasek; Yves Nordmann; Manfred O Doss
Molecular, immunological, enzymatic and biochemical studies of coproporphyrinogen oxidase deficiency in a family with hereditary coproporphyria.
Cellular and molecular biology (Noisy-le-Grand, France) 2002;48(1):49-55.
2001: Susan M E Smith; Caroline Sham; Linda Roman; Pavel Martasek; John Salerno
Titration of low K(d) binding sites: binding of arginine analogs to nitric oxide synthases.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2001;5(5):442-52.
2000: Erik S G Stroes; Ernst E van Faassen; M Yo; Pavel Martasek; Peter Boer; R Govers; ton rabelink
Folic acid reverts dysfunction of endothelial nitric oxide synthase.
Circulation research 2000;86(11):1129-34.
1999: Y Lee; Pavel Martasek; Linda Roman; Bettie Sue Masters; Richard B Silverman
Imidazole-containing amino acids as selective inhibitors of nitric oxide synthases.
Bioorganic & medicinal chemistry 1999;7(9):1941-51.
1999: H Huang; Pavel Martasek; Linda Roman; Bettie Sue Masters; Richard B Silverman
N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase.
Journal of medicinal chemistry 1999;42(16):3147-53.
1999: Y Lee; Michael A Marletta; Pavel Martasek; Linda Roman; Bettie Sue Masters; Richard B Silverman
Conformationally-restricted arginine analogues as alternative substrates and inhibitors of nitric oxide synthases.
Bioorganic & medicinal chemistry 1999;7(6):1097-104.
1999: D L Tierney; H Huang; Pavel Martasek; Bettie Sue Masters; Richard B Silverman; Brian M Hoffman
ENDOR spectroscopic evidence for the position and structure of NG-hydroxy-L-arginine bound to holo-neuronal nitric oxide synthase.
Biochemistry 1999;38(12):3704-10.
1998: Andrew G Roberts; Hervé Puy; Tamara A Dailey; Rhian R Morgan; Sharon D Whatley; Harry A. Dailey; Pavel Martasek; Yves Nordmann; Jean-Charles Deybach; George H Elder
Molecular characterization of homozygous variegate porphyria.
Human molecular genetics 1998;7(12):1921-5.
1997: H Q Zhang; Walter Fast; Michael A Marletta; Pavel Martasek; Richard B Silverman
Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine.
Journal of medicinal chemistry 1997;40(24):3869-70.
1997: John Salerno; D E Harris; K Irizarry; B Patel; A J Morales; Susan M E Smith; Pavel Martasek; Linda Roman; Bettie Sue Masters; C L Jones; B A Weissman; P Lane; Q Liu; Steven S Gross
An autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthase.
The Journal of biological chemistry 1997;272(47):29769-77.
1997: Guillermo García-Cardeña; Pavel Martasek; Bettie Sue Masters; P M Skidd; J Couet; Shengwen Li; M P Lisanti; William C Sessa
Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo.
The Journal of biological chemistry 1997;272(41):25437-40.
1997: Jeannette Vásquez-Vivar; Pavel Martasek; Neil Hogg; Bettie Sue Masters; Kirkwood A Pritchard; Balaraman Kalyanaraman
Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin.
Biochemistry 1997;36(38):11293-7.
1997: Catharina T Migita; John Salerno; Bettie Sue Masters; Pavel Martasek; K McMillan; Masao Ikeda-Saito
Substrate binding-induced changes in the EPR spectra of the ferrous nitric oxide complexes of neuronal nitric oxide synthase.
Biochemistry 1997;36(36):10987-92.
1997: Richard B Silverman; H Huang; Michael A Marletta; Pavel Martasek
Selective inhibition of neuronal nitric oxide synthase by N omega-nitroarginine-and phenylalanine-containing dipeptides and dipeptide esters.
Journal of medicinal chemistry 1997;40(18):2813-7.
1997: Robert Rosipal; Hervé Puy; Jérôme Lamoril; Pavel Martasek; Yves Nordmann; Jean-Charles Deybach
Molecular analysis of porphobilinogen (PBG) deaminase gene mutations in acute intermittent porphyria: first study in patients of Slavic origin.
Scandinavian journal of clinical and laboratory investigation 1997;57(3):217-24.
1997: Jeannette Vásquez-Vivar; Neil Hogg; Kirkwood A Pritchard; Pavel Martasek; Balaraman Kalyanaraman
Superoxide anion formation from lucigenin: an electron spin resonance spin-trapping study.
FEBS letters 1997;403(2):127-30.
1996: John Salerno; Pavel Martasek; Linda Roman; Bettie Sue Masters
Electron paramagnetic resonance spectroscopy of the heme domain of inducible nitric oxide synthase: binding of ligands at the arginine site induces changes in the heme ligation geometry.
Biochemistry 1996;35(24):7626-30.
1996: Bettie Sue Masters; K McMillan; Essam Sheta; J S Nishimura; Linda Roman; Pavel Martasek
Neuronal nitric oxide synthase, a modular enzyme formed by convergent evolution: structure studies of a cysteine thiolate-liganded heme protein that hydroxylates L-arginine to produce NO. as a cellular signal.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(5):552-8.
1996: Pavel Martasek; Q Liu; J Liu; Linda Roman; Steven S Gross; William C Sessa; Bettie Sue Masters
Characterization of bovine endothelial nitric oxide synthase expressed in E. coli.
Biochemical and biophysical research communications 1996;219(2):359-65.
1996: Bettie Sue Masters; K McMillan; J Nishimura; Pavel Martasek; Linda Roman; E Sheta; Steven S Gross; J Salerno
Understanding the structural aspects of neuronal nitric oxide synthase (NOS) using microdissection by molecular cloning techniques: molecular dissection of neuronal NOS.
Advances in experimental medicine and biology 1996;387():163-9.
1995: Linda Roman; Essam Sheta; Pavel Martasek; Steven S Gross; Q Liu; Bettie Sue Masters
High-level expression of functional rat neuronal nitric oxide synthase in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8428-32.
1995: J S Nishimura; Pavel Martasek; K McMillan; J Salerno; Q Liu; Steven S Gross; Bettie Sue Masters
Modular structure of neuronal nitric oxide synthase: localization of the arginine binding site and modulation by pterin.
Biochemical and biophysical research communications 1995;210(2):288-94.
1995: Jérôme Lamoril; Pavel Martasek; Jean-Charles Deybach; Vasco Da Silva; Bernard Grandchamp; Yves Nordmann
A molecular defect in coproporphyrinogen oxidase gene causing harderoporphyria, a variant form of hereditary coproporphyria.
Human molecular genetics 1995;4(2):275-8.
1988: P Kotal; Milan Jirsa; I Klepacek; Pavel Martasek; V Kordac
Porphyrinostatic effect of isonicotinic acid hydrazide on porphyric chick embryo and yeast.
The International journal of biochemistry 1988;20(11):1281-3.