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George Martin

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Fuki M Hisama; Christian Kubisch; George M Martin; Oshima Junko
Clinical utility gene card for: Werner syndrome.
George M Martin
Stochastic modulations of the pace and patterns of ageing: impacts on quasi-stochastic distributions of multiple geriatric pathologies.
George M Martin
The biology of aging: 1985-2010 and beyond.

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All Publications

2012: Fuki M Hisama; Christian Kubisch; George M Martin; Oshima Junko
Clinical utility gene card for: Werner syndrome.
European journal of human genetics : EJHG 2012;20(5):.
2012: George M Martin
Stochastic modulations of the pace and patterns of ageing: impacts on quasi-stochastic distributions of multiple geriatric pathologies.
Mechanisms of ageing and development 2012;133(4):107-11.
2011: George M Martin
The biology of aging: 1985-2010 and beyond.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(11):3756-62.
2010: Rosa-Ana Risques; Konstantin G Arbeev; Anatoli I Yashin; Svetlana V Ukraintseva; George M Martin; Peter S Rabinovitch; Oshima Junko
Leukocyte telomere length is associated with disability in older u.s. Population.
Journal of the American Geriatrics Society 2010;58(7):1289-98.
2010: Bethany H Cool; Guy C-K Chan; Lin Lee; Oshima Junko; George M Martin; Qubai Hu
A flanking gene problem leads to the discovery of a Gprc5b splice variant predominantly expressed in C57Bl/6J mouse brain and in maturing neurons.
PloS one 2010;5(4):e10351.
2010: Bethany H Cool; Galynn Zitnik; George M Martin; Qubai Hu
Structural and functional characterization of a novel FE65 protein product up-regulated in cognitively impaired FE65 knockout mice.
Journal of neurochemistry 2010;112(2):410-9.
2009: George M Martin
Epigenetic gambling and epigenetic drift as an antagonistic pleiotropic mechanism of aging.
Aging cell 2009;8(6):761-4.
2009: Yan Wang; Ming Zhang; Changjong Moon; Qubai Hu; Baiping Wang; George M Martin; Zhongsheng Sun; Hongbing Wang
The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation.
Learning & memory (Cold Spring Harbor, N.Y.) 2009;16(9):537-44.
2009: Dao-Fu Dai; Luis F Santana; Marc Vermulst; Daniela M Tomazela; Mary J Emond; Michael J MacCoss; Katherine Gollahon; George M Martin; Lawrence A Loeb; Warren C Ladiges; Peter S Rabinovitch
Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging.
Circulation 2009;119(21):2789-97.
2009: George M Martin
The 2008 American Federation For Aging Annual Research Conference: aging and cancer: two sides of the same coin?
The journals of gerontology. Series A, Biological sciences and medical sciences 2009;64(6):615-7.
2009: Nalvo F Almeida; Shuangchun Yan; Magdalen Lindeberg; David J Studholme; David J Schneider; Bradford Condon; Haijie Liu; Carlos J Viana; Andrew Warren; Clive Evans; Eric Kemen; Dan Maclean; Aurelie Angot; George M Martin; Jonathan D Jones; Alan Collmer; Joao Setubal; Boris A Vinatzer
A draft genome sequence of Pseudomonas syringae pv. tomato T1 reveals a type III effector repertoire significantly divergent from that of Pseudomonas syringae pv. tomato DC3000.
Molecular plant-microbe interactions : MPMI 2009;22(1):52-62.
2008: piper meigs treuting; Nancy J Linford; Sue E Knoblaugh; M J Emond; John F Morton; George M Martin; Peter S Rabinovitch; Warren C Ladiges
Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria.
The journals of gerontology. Series A, Biological sciences and medical sciences 2008;63(8):813-22.
2008: Alexander Kulminski; Svetlana V Ukraintseva; Konstantin G Arbeev; Kenneth G Manton; Oshima Junko; George M Martin; Anatoliy Yashin
Association between APOE epsilon 2/epsilon 3/epsilon 4 polymorphism and disability severity in a national long-term care survey sample.
Age and ageing 2008;37(3):288-93.
2008: Alexander Kulminski; Svetlana V Ukraintseva; Konstantin G Arbeev; Kenneth G Manton; Oshima Junko; George M Martin; Dora Il'yasova; Anatoliy Yashin
Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older men.
Journal of the American Geriatrics Society 2008;56(3):478-83.
2008: Robert N Butler; Richard A Miller; Daniel Perry; Bruce A Carnes; T Franklin Williams; Christine Cassel; Jacob Brody ; Marie A Bernard; Linda Partridge; Thomas Kirkwood; George M Martin; S Jay Olshansky
New model of health promotion and disease prevention for the 21st century.
BMJ (Clinical research ed.) 2008;337():a399.
2008: Shurong Huang; Rosa-Ana Risques; George M Martin; Peter S Rabinovitch; Oshima Junko
Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A.
Experimental cell research 2008;314(1):82-91.
2007: George M Martin
Clonal attenuation of somatic cells in aging mammals: a review of supportive evidence and its biomedical significance.
Annals of the New York Academy of Sciences 2007;1119():1-8.
2007: George M Martin; Aviv Bergman; Nir Barzilai
Genetic determinants of human health span and life span: progress and new opportunities.
PLoS genetics 2007;3(7):e125.
2007: George M Martin
Modalities of gene action predicted by the classical evolutionary biological theory of aging.
Annals of the New York Academy of Sciences 2007;1100():14-20.
2007: Desiree Nguyen; Dru F Leistritz; Lesley Turner; David MacGregor; Kamal Ohson; Paul Dancey; George M Martin; Oshima Junko
Collagen expression in fibroblasts with a novel LMNA mutation.
Biochemical and biophysical research communications 2007;352(3):603-8.
2007: Galynn Zitnik; Lin Wang; George M Martin; Qubai Hu
Localizations of endogenous APP/APP-proteolytic products are consistent with microtubular transport.
Journal of molecular neuroscience : MN 2007;31(1):59-68.
2007: Jing Shao; Lishan Chen; Brian Marrs; Lin Lee; Hai Huang; Kenneth G Manton; George M Martin; Oshima Junko
SOD2 polymorphisms: unmasking the effect of polymorphism on splicing.
BMC medical genetics 2007;8():7.
2007: George M Martin
The genetics and epigenetics of altered proliferative homeostasis in ageing and cancer.
Mechanisms of ageing and development 2007;128(1):9-12.
2006: George M Martin; Don Kennedy
SAGE lessons.
Science (New York, N.Y.) 2006;313(5783):17.
2006: Izumi Maezawa; Hyun-Seok Hong; Hui-Chuan Wu; Srinivas K Battina; Sandeep Rana; Takeo Iwamoto; Gary A Radke; Erik Pettersson; George M Martin; Duy H Hua; Lee-Way Jin
A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes.
Journal of neurochemistry 2006;98(1):57-67.
2006: Shurong Huang; Lin Lee; Nancy B Hanson; Catherine Lenaerts; Holger Hoehn; Martin Poot; Craig D Rubin; Da-Fu Chen; Chih-Chao Yang; Heike Juch; Thomas Dorn; Roland Spiegel; Elif Arioglu Oral; Mohammed Abid; Carla Battisti; Emanuela Lucci-Cordisco; Giovanni Neri; Erin H Steed; Alexa Kidd; William Isley; David Showalter; Janet L Vittone; Alexander Konstantinow; Johannes Ring; Peter Meyer; Sharon L Wenger; Axel von Herbay; Uwe Wollina; Markus Schuelke; Carin Espenschied; Dru F Leistritz; George M Martin; I Saira Mian; Oshima Junko
The spectrum of WRN mutations in Werner syndrome patients.
Human mutation 2006;27(6):558-67.
2006: George M Martin
Keynote lecture: an update on the what, why and how questions of ageing.
Experimental gerontology 2006;41(5):460-3.
2006: Zheng Yang; Bethany H Cool; George M Martin; Qubai Hu
A dominant role for FE65 (APBB1) in nuclear signaling.
The Journal of biological chemistry 2006;281(7):4207-14.
2005: Lawrence A Loeb; Douglas C Wallace; George M Martin
The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):18769-70.
2005: George M Martin
The American Aging Association honors Huber R. Warner, PhD., Retiring Associate Director, National Institute on Aging.
Age (Dordrecht, Netherlands) 2005;27(4):319-20.
2005: George M Martin
Genetic engineering of mice to test the oxidative damage theory of aging.
Annals of the New York Academy of Sciences 2005;1055():26-34.
2005: Shurong Huang; Lishan Chen; Nataliya Libina; Joel Janes; George M Martin; Judith Campisi; Oshima Junko
Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference.
Human genetics 2005;118(3-4):444-50.
2005: Norman Wolf; Philip Penn; William R Pendergrass; Holly Van Remmen; Andrzej Bartke; Peter S Rabinovitch; George M Martin
Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence.
Experimental eye research 2005;81(3):276-85.
2005: George M Martin
Epigenetic drift in aging identical twins.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(30):10413-4.
2005: Samuel E Schriner; Nancy J Linford; George M Martin; piper meigs treuting; Charles E Ogburn; Mary J Emond; Pinar E Coskun; Warren C Ladiges; Norman Wolf; Holly Van Remmen; Douglas C Wallace; Peter S Rabinovitch
Extension of murine life span by overexpression of catalase targeted to mitochondria.
Science (New York, N.Y.) 2005;308(5730):1909-11.
2005: Qubai Hu; Lin Wang; Zheng Yang; Bethany H Cool; Galynn Zitnik; George M Martin
Endoproteolytic cleavage of FE65 converts the adaptor protein to a potent suppressor of the sAPPalpha pathway in primates.
The Journal of biological chemistry 2005;280(13):12548-58.
2005: George M Martin
Genetic modulation of senescent phenotypes in Homo sapiens.
Cell 2005;120(4):523-32.
2004: George M Martin
Genes, rates of aging, and duration of human life.
The American journal of medicine 2004;117(11):882-3.
2004: Izumi Maezawa; Lee-Way Jin; Randall L Woltjer; Nobuyo Maeda; George M Martin; Thomas J Montine; Kathleen S Montine
Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity.
Journal of neurochemistry 2004;91(6):1312-21.
2004: George M Martin
New opportunities for genetic approaches to aging research using Roy Walford's favorite animal.
Experimental gerontology 2004;39(6):913-6.
2004: George M Martin; Lawrence A Loeb
Ageing: mice and mitochondria.
Nature 2004;429(6990):357-9.
2004: Robert N Butler; Huber R Warner; T Franklin Williams; Steven Austad; Jacob Brody ; Judith Campisi; Anthony Cerami; Gene Cohen; Vincent J Cristofalo; David Drachman; Caleb E Finch; Irwin Fridovich; Calvin B Harley; Richard J Havlik; George M Martin; Richard A Miller; S Jay Olshansky; Olivia M Pereira-Smith; James R Smith; Richard L Sprott; Michael D West; John R Wilmoth; Woodring E Wright
The aging factor in health and disease: the promise of basic research on aging.
Aging clinical and experimental research 2004;16(2):104-11; discussion 111-2.
2004: Debra Revere; Sherrilynne Fuller; Paul F Bugni; George M Martin
An information extraction and representation system for rapid review of the biomedical literature.
Studies in health technology and informatics 2004;107(Pt 2):788-92.
2004: Baiping Wang; Qubai Hu; Mark G Hearn; Kimiko Shimizu; Carol B Ware; Dennis H Liggitt; Lee-Way Jin; Bethany H Cool; Daniel R Storm; George M Martin
Isoform-specific knockout of FE65 leads to impaired learning and memory.
Journal of neuroscience research 2004;75(1):12-24.
2003: Lishan Chen; Lin Lee; Brian A Kudlow; Heloisa G Dos Santos; Olav Sletvold; Yousef Shafeghati; Eleanor G Botha; Abhimanyu Garg; Nancy B Hanson; George M Martin; I Saira Mian; Brian Kennedy; Oshima Junko
LMNA mutations in atypical Werner's syndrome.
Lancet 2003;362(9382):440-5.
2003: George M Martin; Kelly LaMarco; Evelyn Strauss; Katrina L Kelner
Research on aging: the end of the beginning.
Science (New York, N.Y.) 2003;299(5611):1339-41.
2002: George M Martin
The evolutionary substrate of aging.
Archives of neurology 2002;59(11):1702-5.
2002: Galynn Zitnik; George M Martin
Age-related decline in neurogenesis: old cells or old environment?
Journal of neuroscience research 2002;70(3):258-63.
2002: Izumi Maezawa; Baiping Wang; Qubai Hu; George M Martin; Lee-Way Jin; Oshima Junko
Alterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicity.
Pathology international 2002;52(9):551-4.
2002: George M Martin
Gene action in the aging brain: an evolutionary biological perspective.
Neurobiology of aging 2002;23(5):647-54.
2002: Lee-Way Jin; Duy H Hua; Feng-Shiun Shie; Izumi Maezawa; Bryce L Sopher; George M Martin
Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death.
Journal of molecular neuroscience : MN 2002;19(1-2):57-61.
2002: George M Martin
Help wanted: physiologists for research on aging.
Science of aging knowledge environment : SAGE KE 2002;2002(9):vp2.
2002: Qubai Hu; Bethany H Cool; Baiping Wang; Mark G Hearn; George M Martin
A candidate molecular mechanism for the association of an intronic polymorphism of FE65 with resistance to very late onset dementia of the Alzheimer type.
Human molecular genetics 2002;11(4):465-75.
2002: Naoki Nihei; Natalay Kouprina; Vladimir Larionov; Oshima Junko; George M Martin; Tomohiko Ichikawa; J Carl Barrett
Functional evidence for a metastasis suppressor gene for rat prostate cancer within a 60-kilobase region on human chromosome 8p21-p12.
Cancer research 2002;62(2):367-70.
2002: George M Martin
Keynote: mechanisms of senescence--complificationists versus simplificationists.
Mechanisms of ageing and development 2002;123(2-3):65-73; discussion 75-9.
2001: Ruiben Feng; C Rampon; Ya-Ping Tang; David Shrom; J Jin; Maureen Kyin; Bryce L Sopher; M W Miller; C B Ware; George M Martin; Seong-Hun Kim; R B Langdon; Sangram S Sisodia; Joseph Zhuo Tsien
Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces.
Neuron 2001;32(5):911-26.
2001: Charles E Ogburn; K Carlberg; Mary Ann Ottinger; Donna J Holmes; George M Martin; Steven Austad
Exceptional cellular resistance to oxidative damage in long-lived birds requires active gene expression.
The journals of gerontology. Series A, Biological sciences and medical sciences 2001;56(11):B468-74.
2001: George M Martin
Frontiers of aging.
Science (New York, N.Y.) 2001;294(5540):13.
2001: George M Martin
SAGE KE: an intellectual home for scientists who seek to understand why and how organisms age.
Science of aging knowledge environment : SAGE KE 2001;2001(1):vp2.
2001: N P Singh; Charles E Ogburn; Norman S Wolf; Gerald van Belle; George M Martin
DNA double-strand breaks in mouse kidney cells with age.
Biogerontology 2001;2(4):261-70.
2000: E Castro; Steven D Edland; Lin Lee; Charles E Ogburn; S S Deeb; G Brown; A Panduro; R Riestra; R Tilvis; J Louhija; R Penttinen; R Erkkola; L Wang; George M Martin; Oshima Junko
Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis.
American journal of medical genetics 2000;95(4):374-80.
2000: George M Martin; Oshima Junko
Lessons from human progeroid syndromes.
Nature 2000;408(6809):263-6.
2000: George M Martin; S L Bressler
Transcriptional infidelity in aging cells and its relevance for the Orgel hypothesis.
Neurobiology of aging 2000;21(6):897-900; discussion 903-4.
2000: Samuel E Schriner; Charles E Ogburn; A C Smith; TG Newcomb; Warren C Ladiges; Martijn E T Dollé; Jan Vijg; Ken-Ichiro Fukuchi; George M Martin
Levels of DNA damage are unaltered in mice overexpressing human catalase in nuclei.
Free radical biology & medicine 2000;29(7):664-73.
2000: George M Martin
Molecular mechanisms of late life dementias.
Experimental gerontology 2000;35(4):439-43.
2000: George M Martin
Some new directions for research on the biology of aging.
Annals of the New York Academy of Sciences 2000;908():1-13.
2000: Samuel E Schriner; A C Smith; N H Dang; Ken-Ichiro Fukuchi; George M Martin
Overexpression of wild-type and nuclear-targeted catalase modulates resistance to oxidative stress but does not alter spontaneous mutant frequencies at APRT.
Mutation research 2000;449(1-2):21-31.
2000: Qubai Hu; Lee-Way Jin; M Y Starbuck; George M Martin
Broadly altered expression of the mRNA isoforms of FE65, a facilitator of beta amyloidogenesis, in Alzheimer cerebellum and other brain regions.
Journal of neuroscience research 2000;60(1):73-86.
2000: L Wang; Charles E Ogburn; Carol B Ware; Warren C Ladiges; H Youssoufian; George M Martin; Oshima Junko
Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.
Genetics 2000;154(1):357-62.
1999: L Wang; A E Evans; Charles E Ogburn; H Youssoufian; George M Martin; Oshima Junko
Werner helicase expression in human fetal and adult aortas.
Experimental gerontology 1999;34(8):935-41.
1999: Qubai Hu; Mark G Hearn; Lee-Way Jin; S L Bressler; George M Martin
Alternatively spliced isoforms of FE65 serve as neuron-specific and non-neuronal markers.
Journal of neuroscience research 1999;58(5):632-40.
1999: George M Martin; Oshima Junko; Matthew D Gray; Martin Poot
What geriatricians should know about the Werner syndrome.
Journal of the American Geriatrics Society 1999;47(9):1136-44.
1999: Adayabalam S Balajee; Amrita Machwe; Alfred May; Matthew D Gray; Oshima Junko; George M Martin; JO Nehlin; Robert M Brosh; David K Orren; Vilhelm A Bohr
The Werner syndrome protein is involved in RNA polymerase II transcription.
Molecular biology of the cell 1999;10(8):2655-68.
1999: George M Martin
APOE alleles and lipophylic pathogens.
Neurobiology of aging 1999;20(4):441-3.
1999: P R Prince; Charles E Ogburn; MJ Moser; Mary J Emond; George M Martin; Raymond J Monnat
Cell fusion corrects the 4-nitroquinoline 1-oxide sensitivity of Werner syndrome fibroblast cell lines.
Human genetics 1999;105(1-2):132-8.
1999: Qing Guo; L Sebastian; Bryce L Sopher; MW Miller; GW Glazner; Carol B Ware; George M Martin; Mark P Mattson
Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):4125-30.
1999: Qing Guo; L Sebastian; Bryce L Sopher; MW Miller; Carol B Ware; George M Martin; Mark P Mattson
Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.
Journal of neurochemistry 1999;72(3):1019-29.
1999: E Castro; Charles E Ogburn; Kathleen E Hunt; R Tilvis; J Louhija; R Penttinen; R Erkkola; A Panduro; R Riestra; C Piussan; S S Deeb; L Wang; Steven D Edland; George M Martin; Oshima Junko
Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians.
American journal of medical genetics 1999;82(5):399-403.
1999: Qing Guo; Weiming Fu; Bryce L Sopher; MW Miller; Carol B Ware; George M Martin; Mark P Mattson
Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.
Nature medicine 1999;5(1):101-6.
1998: Lee-Way Jin; M G Hearn; Charles E Ogburn; Nick Dang; David Nochlin; Warren C Ladiges; George M Martin
Transgenic mice over-expressing the C-99 fragment of betaPP with an alpha-secretase site mutation develop a myopathy similar to human inclusion body myositis.
The American journal of pathology 1998;153(6):1679-86.
1998: George M Martin
Atherosclerosis is the leading cause of death in the developed societies.
The American journal of pathology 1998;153(4):1319-20.
1998: Qubai Hu; Walter A Kukull; S L Bressler; Matthew D Gray; J A Cam; Eric B Larson; George M Martin; Samir S Deeb
The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type.
Human genetics 1998;103(3):295-303.
1998: George M Martin
Introduction: genetic determinants of mid- and late-life dementias.
Cellular and molecular life sciences : CMLS 1998;54(9):895-6.
1998: Matthew D Gray; L Wang; H Youssoufian; George M Martin; Oshima Junko
Werner helicase is localized to transcriptionally active nucleoli of cycling cells.
Experimental cell research 1998;242(2):487-94.
1998: L Wang; Kathleen E Hunt; George M Martin; Oshima Junko
Structure and function of the human Werner syndrome gene promoter: evidence for transcriptional modulation.
Nucleic acids research 1998;26(15):3480-5.
1998: Charles E Ogburn; Steven Austad; Donna J Holmes; J V Kiklevich; Katherine A Gollahon; Peter S Rabinovitch; George M Martin
Cultured renal epithelial cells from birds and mice: enhanced resistance of avian cells to oxidative stress and DNA damage.
The journals of gerontology. Series A, Biological sciences and medical sciences 1998;53(4):B287-92.
1998: George M Martin
The genetics of aging.
Aging (Milan, Italy) 1998;10(2):148-9.
1998: George M Martin; E Wang
Aging andlongevity: towards the next millennium. The Bat Sheva Le Rothschild International Seminar on Cellular, Molecular and Genetic Aspects of Aging and Longevity. Zichron Yaacov, Israel, 7-12 December 1997.
Molecular medicine today 1998;4(4):145.
1998: Walter A Kukull; George M Martin
APOE polymorphisms and late-onset Alzheimer disease: the importance of ethnicity.
JAMA : the journal of the American Medical Association 1998;279(10):788-9.
1997: George M Martin
Genetics and the pathobiology of ageing.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1997;352(1363):1773-80.
1997: Charles E Ogburn; Oshima Junko; Martin Poot; R Chen; Kathleen E Hunt; Katherine A Gollahon; Peter S Rabinovitch; George M Martin
An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants.
Human genetics 1997;101(2):121-5.
1997: George M Martin; I S Mian
Ageing. New mice for old questions.
Nature 1997;390(6655):18-9.
1997: Matthew D Gray; Jiang Cheng Shen; Ashwini S Kamath-Loeb; A Blank; Bryce L Sopher; George M Martin; Oshima Junko; Lawrence A Loeb
The Werner syndrome protein is a DNA helicase.
Nature genetics 1997;17(1):100-3.
1997: George M Martin
The Werner mutation: does it lead to a "public" or "private" mechanism of aging?
Molecular medicine (Cambridge, Mass.) 1997;3(6):356-8.
1997: Qing Guo; Bryce L Sopher; K Furukawa; D G Pham; N Robinson; George M Martin; Mark P Mattson
Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(11):4212-22.
1997: K A Walker; C Darrell Jennings; Joseph F Pulliam; Charles E Ogburn; George M Martin; M Urano; Mitchell S Turker
A cell line selected for resistance to ionizing radiation exhibits cross resistance to other genotoxic agents and a mutator phenotype for loss of heterozygosity events.
Somatic cell and molecular genetics 1997;23(2):111-21.
1997: George M Martin
The genetics of aging.
Hospital practice (1995) 1997;32(2):47-50, 55-6, 59-61 passim.
1997: L Ye; Tsuneharu Miki; Jun Nakura; Oshima Junko; Kouzin Kamino; H Rakugi; H Ikegami; J Higaki; Steven D Edland; George M Martin; Toshio Ogihara
Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population.
American journal of medical genetics 1997;68(4):494-8.
1997: Chang-En Yu; Oshima Junko; Ellen M Wijsman; Jun Nakura; T Miki; C Piussan; S Matthews; Y H Fu; J Mulligan; George M Martin; Gerard D Schellenberg
Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group.
American journal of human genetics 1997;60(2):330-41.
1996: Qing Guo; K Furukawa; Bryce L Sopher; D G Pham; J Xie; N Robinson; George M Martin; Mark P Mattson
Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide.
Neuroreport 1996;8(1):379-83.
1996: Oshima Junko; Chang-En Yu; C Piussan; G Klein; J Jabkowski; S Balci; T Miki; Jun Nakura; T Ogihara; J Ells; M Smith; M I Melaragno; M Fraccaro; Susi Scappaticci; J Matthews; S Ouais; A Jarzebowicz; Gerard D Schellenberg; George M Martin
Homozygous and compound heterozygous mutations at the Werner syndrome locus.
Human molecular genetics 1996;5(12):1909-13.
1996: K Furukawa; Bryce L Sopher; Russell E Rydel; Jim G Begley; D G Pham; George M Martin; M Fox; Mark P Mattson
Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain.
Journal of neurochemistry 1996;67(5):1882-96.
1996: Oshima Junko; W T Brown; George M Martin
No detectable mutations at Werner helicase locus in progeria.
Lancet 1996;348(9034):1106.
1996: Bryce L Sopher; Ken-Ichiro Fukuchi; Terrance J Kavanagh; Clement E Furlong; George M Martin
Neurodegenerative mechanisms in Alzheimer disease. A role for oxidative damage in amyloid beta protein precursor-mediated cell death.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1996;29(2-3):153-68.
1996: S L Bressler; Matthew D Gray; Bryce L Sopher; Qubai Hu; M G Hearn; D G Pham; MB Dinulos; Ken-Ichiro Fukuchi; Sangram S Sisodia; M A Miller; Christine M Disteche; George M Martin
cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein.
Human molecular genetics 1996;5(10):1589-98.
1996: George M Martin; Walter A Kukull
Do cultural differences affect Alzheimer disease?
JAMA : the journal of the American Medical Association 1996;276(12):993-5.
1996: Jun Nakura; T Miki; L Ye; Noriaki Mitsuda; Y Zhao; K Kihara; Chang-En Yu; Oshima Junko; Ken-Ichiro Fukuchi; Ellen M Wijsman; Gerard D Schellenberg; George M Martin; S i Murano; Katsuyuki Hashimoto; Y Fujiwara; Toshio Ogihara
Narrowing the position of the Werner syndrome locus by homozygosity analysis-extension of homozygosity analysis.
Genomics 1996;36(1):130-41.
1996: Ken-Ichiro Fukuchi; L Ho; Steven G Younkin; D D Kunkel; Charles E Ogburn; Renée C LeBoeuf; C E Furlong; Samir S Deeb; David Nochlin; J Wegiel; Henryk M Wisniewski; George M Martin
High levels of circulating beta-amyloid peptide do not cause cerebral beta-amyloidosis in transgenic mice.
The American journal of pathology 1996;149(1):219-27.
1996: Katrina Goddard; Chang-En Yu; Oshima Junko; T Miki; Jun Nakura; C Piussan; George M Martin; Gerard D Schellenberg; Ellen M Wijsman
Toward localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: lessons learned from analysis of 35 chromosome 8p11.1-21.1 markers.
American journal of human genetics 1996;58(6):1286-302.
1996: V P Schulz; Virginia A Zakian; Charles E Ogburn; J McKay; A A Jarzebowicz; Steven D Edland; George M Martin
Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells.
Human genetics 1996;97(6):750-4.
1996: Ken-Ichiro Fukuchi; T Ohman; N Dang; A C Smith; C E Furlong; George M Martin
Overexpressions of cDNAs for beta-amyloid precursor proteins 695, 751, and 770 enhance the secretion of beta-amyloid precursor protein derivatives and the survival of P19-derived neurons.
Journal of neurochemistry 1996;66(5):2201-4.
1996: George M Martin; Steven Austad; Thomas Johnson
Genetic analysis of ageing: role of oxidative damage and environmental stresses.
Nature genetics 1996;13(1):25-34.
1996: Chang-En Yu; Oshima Junko; Y H Fu; Ellen M Wijsman; Fuki M Hisama; R Alisch; S Matthews; Jun Nakura; T Miki; S Ouais; George M Martin; J Mulligan; Gerard D Schellenberg
Positional cloning of the Werner's syndrome gene.
Science (New York, N.Y.) 1996;272(5259):258-62.
1996: George M Martin
Fak and focal adhesions.
Japanese journal of cancer research : Gann 1996;87(3):inside front cover.
1996: George M Martin
Somatic mutagenesis and antimutagenesis in aging research.
Mutation research 1996;350(1):35-41.
1996: George M Martin; Charles E Ogburn; Lorel M Colgin; A M Gown; Steven D Edland; Raymond J Monnat
Somatic mutations are frequent and increase with age in human kidney epithelial cells.
Human molecular genetics 1996;5(2):215-21.
1996: George M Martin
Genetic modulation of the senescent phenotype of Homo sapiens.
Experimental gerontology 1996;31(1-2):49-59.
1995: N Eriksen; S B Kumar; Ken-Ichiro Fukuchi; George M Martin; E P Benditt
Molecular mimicry: histone H3 and mycobacterial protein epitopes.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):2150-3.
1995: Oshima Junko; Judith Campisi; T C Tannock; George M Martin
Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors.
Journal of cellular physiology 1995;162(2):277-83.
1994: M G Hearn; Steven D Edland; Charles E Ogburn; A C Smith; Thomas D Bird; George M Martin; Ken-Ichiro Fukuchi
Trypsin inhibitor activities of fibroblasts increase with age of donor and are unaltered in familial Alzheimer's disease.
Experimental gerontology 1994;29(6):611-23.
1994: George M Martin
Genetic modulation of telomeric terminal restriction-fragment length: relevance for clonal aging and late-life disease.
American journal of human genetics 1994;55(5):866-9.
1994: Bryce L Sopher; Ken-Ichiro Fukuchi; A C Smith; Kathleen A Leppig; Clement E Furlong; George M Martin
Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the beta-amyloid precursor protein.
Brain research. Molecular brain research 1994;26(1-2):207-17.
1994: Oshima Junko; Chang-En Yu; M Boehnke; J L Weber; S Edelhoff; M J Wagner; Dan E Wells; S Wood; Christine M Disteche; George M Martin
Integrated mapping analysis of the Werner syndrome region of chromosome 8.
Genomics 1994;23(1):100-13.
1994: Charles E Ogburn; Mitchell S Turker; Terrance J Kavanagh; Christine M Disteche; A C Smith; Ken-Ichiro Fukuchi; George M Martin
Oxygen-resistant multipotent embryonic carcinoma cell lines exhibit antimutator phenotypes.
Somatic cell and molecular genetics 1994;20(5):361-70.
1994: Ken-Ichiro Fukuchi; D D Kunkel; Philip A Schwartzkroin; K Kamino; Charles E Ogburn; C E Furlong; George M Martin
Overexpression of a C-terminal portion of the beta-amyloid precursor protein in mouse brains by transplantation of transformed neuronal cells.
Experimental neurology 1994;127(2):253-64.
1994: Ken-Ichiro Fukuchi; M G Hearn; S S Deeb; A C Smith; N Dang; J Miyazaki; Mark Bothwell; George M Martin
Activity assays of nine heterogeneous promoters in neural and other cultured cells.
In vitro cellular & developmental biology. Animal 1994;30A(5):300-5.
1994: Terrance J Kavanagh; G Raghu; Collin C White; George M Martin; Peter S Rabinovitch; David Eaton
Enhancement of glutathione content in glutathione synthetase-deficient fibroblasts from a patient with 5-oxoprolinuria via metabolic cooperation with normal fibroblasts.
Experimental cell research 1994;212(1):69-76.
1993: Ken-Ichiro Fukuchi; Charles E Ogburn; A C Smith; D D Kunkel; C E Furlong; Samir S Deeb; David Nochlin; Shuzo M Sumi; George M Martin
Transgenic animal models for Alzheimer's disease.
Annals of the New York Academy of Sciences 1993;695():217-23.
1993: George M Martin
Clonal attenuation: causes and consequences.
Journal of gerontology 1993;48(5):B171-2.
1993: George M Martin
FRAR course on laboratory approaches to aging. "Orphan" phenotypes in gerontological research.
Aging (Milan, Italy) 1993;5(4):325-32.
1993: Ken-Ichiro Fukuchi; Bryce L Sopher; C E Furlong; A C Smith; N Dang; George M Martin
Selective neurotoxicity of COOH-terminal fragments of the beta-amyloid precursor protein.
Neuroscience letters 1993;154(1-2):145-8.
1993: Ken-Ichiro Fukuchi; B Sopher; George M Martin
Neurotoxicity of beta-amyloid.
Nature 1993;361(6408):122-3.
1993: E M Bryant; Thomas D Bird; Charles E Ogburn; G H Traylor; T H Lampe; George M Martin
Lack of detectable radiation hypersensitivity in lymphoblastoid cells from multiple pedigrees of familial Alzheimer disease.
Alzheimer disease and associated disorders 1993;7(2):88-97.
1993: Ellen M Wijsman; Thomas D Bird; George M Martin; Gerard D Schellenberg
The Seattle Alzheimer's disease data set.
Genetic epidemiology 1993;10(6):365-9.
1993: George M Martin
Abiotrophic gene action in Homo sapiens: potential mechanisms and significance for the pathobiology of aging.
Genetica 1993;91(1-3):265-77.
1992: Ken-Ichiro Fukuchi; K Kamino; S S Deeb; Clement E Furlong; J A Sundstrom; A C Smith; George M Martin
Expression of a carboxy-terminal region of the beta-amyloid precursor protein in a heterogeneous culture of neuroblastoma cells: evidence for altered processing and selective neurotoxicity.
Brain research. Molecular brain research 1992;16(1-2):37-46.
1992: George M Martin
Clonal attenuation and cell senescence: the next 30 years.
Experimental gerontology 1992;27(4):455-9.
1992: Ken-Ichiro Fukuchi; Samir S Deeb; K Kamino; Charles E Ogburn; AD Snow; R T Sekiguchi; Thomas N Wight; H Piussan; George M Martin
Increased expression of beta-amyloid protein precursor and microtubule-associated protein tau during the differentiation of murine embryonal carcinoma cells.
Journal of neurochemistry 1992;58(5):1863-73.
1992: Gerard D Schellenberg; George M Martin; E M Wijsman; Jun Nakura; T Miki; T Ogihara
Homozygosity mapping and Werner's syndrome.
Lancet 1992;339(8799):1002.
1992: G D Zitnik; Sarah A Bingel; Shuzo M Sumi; George M Martin
Survival curves, reproductive life span and age-related pathology of Mus caroli.
Laboratory animal science 1992;42(2):119-26.
1992: Gerard D Schellenberg; M Boehnke; Ellen M Wijsman; D K Moore; George M Martin; Thomas D Bird
Genetic association and linkage analysis of the apolipoprotein CII locus and familial Alzheimer's disease.
Annals of neurology 1992;31(2):223-7.
1992: Ken-Ichiro Fukuchi; K Kamino; Samir S Deeb; A C Smith; T Dang; George M Martin
Overexpression of amyloid precursor protein alters its normal processing and is associated with neurotoxicity.
Biochemical and biophysical research communications 1992;182(1):165-73.
1991: Mitchell S Turker; K Z Duffin; A C Smith; George M Martin; A W Martin; D L DiMartino; D S Kersey
Multidrug resistance phenotype associated with selection of an aminopterin resistant dog kidney cell line.
Pharmacogenetics 1991;1(3):149-60.
1991: Gerard D Schellenberg; L Anderson; S O'dahl; E M Wisjman; A D Sadovnick; Melvyn Ball; Eric B Larson; Walter A Kukull; George M Martin; Allen D Roses
APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease.
American journal of human genetics 1991;49(3):511-7.
1991: George M Martin
Genetic and environmental modulations of chromosomal stability: their roles in aging and oncogenesis.
Annals of the New York Academy of Sciences 1991;621():401-17.
1990: Terrance J Kavanagh; A Grossmann; E P Jaecks; J C Jinneman; David Eaton; George M Martin; Peter S Rabinovitch
Proliferative capacity of human peripheral blood lymphocytes sorted on the basis of glutathione content.
Journal of cellular physiology 1990;145(3):472-80.
1990: George M Martin; Gerard D Schellenberg; E M Wijsman; Thomas D Bird
Alzheimer's disease. Dominant susceptibility genes.
Nature 1990;347(6289):124.
1990: Ken-Ichiro Fukuchi; K Tanaka; Y Kumahara; K Marumo; M B Pride; George M Martin; R J Monnat
Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients.
Human genetics 1990;84(3):249-52.
1989: Thomas D Bird; Gerard D Schellenberg; Ellen M Wijsman; George M Martin
Evidence for etiologic heterogeneity in Alzheimer's disease.
Neurobiology of aging 1989;10(5):432-4; discussion 446-8.
1989: Ken-Ichiro Fukuchi; George M Martin; Raymond J Monnat
Mutator phenotype of Werner syndrome is characterized by extensive deletions.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5893-7.
1989: Mitchell S Turker; Karen Swisshelm; A C Smith; George M Martin
A partial methylation profile for a CpG site is stably maintained in mammalian tissues and cultured cell lines.
The Journal of biological chemistry 1989;264(20):11632-6.
1989: Ken-Ichiro Fukuchi; George M Martin; S S Deeb
Sequence of the protease inhibitor domain of the A4 amyloid protein precursor of Mus domesticus.
Nucleic acids research 1989;17(13):5396.
1989: Mitchell S Turker; Peter J Stambrook; Jay Tischfield; A C Smith; George M Martin
Allelic variation linked to adenine phosphoribosyltransferase locus in mouse teratocarcinoma cell line and feral-derived mouse strains.
Somatic cell and molecular genetics 1989;15(2):159-66.
1989: George M Martin
Genetic modulation of the senescent phenotype in Homo sapiens.
Genome / National Research Council Canada = Génome / Conseil national de recherches Canada 1989;31(1):390-7.
1989: Gerard D Schellenberg; Thomas D Bird; Ellen M Wijsman; D K Moore; George M Martin
The genetics of Alzheimer's disease.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1989;43(7):463-8.
1988: Terrance J Kavanagh; George M Martin; John Livesey; Peter S Rabinovitch
Direct evidence of intercellular sharing of glutathione via metabolic cooperation.
Journal of cellular physiology 1988;137(2):353-9.
1988: Mitchell S Turker; Raymond J Monnat; Ken-Ichiro Fukuchi; P A Johnston; Charles E Ogburn; Richard E Weller; J F Park; George M Martin
A novel class of unstable 6-thioguanine-resistant cells from dog and human kidneys.
Cell biology and toxicology 1988;4(2):211-23.
1988: Norman S Wolf; W E Giddens; George M Martin
Life table analysis and pathologic observations in male mice of a long-lived hybrid strain (Af X C57BL/6)F1.
Journal of gerontology 1988;43(3):B71-8.
1988: George M Martin; Mitchell S Turker
Model systems for the genetic analysis of mechanisms of aging.
Journal of gerontology 1988;43(2):B33-9.
1988: George M Martin
Constitutional, somatic genetic and environmental aspects of the phenotypic diversity of aging in human subjects.
Basic life sciences 1988;43():183-90.
1988: George M Martin
Constitutional genetic markers of aging.
Experimental gerontology 1988;23(4-5):257-70.
1987: Terrance J Kavanagh; George M Martin; M H el-Fouly; James E Trosko; C C Chang; Peter S Rabinovitch
Flow cytometry and scrape-loading/dye transfer as a rapid quantitative measure of intercellular communication in vitro.
Cancer research 1987;47(22):6046-51.
1987: S Aizawa; L A Loeb; George M Martin
Aphidicolin-resistant mutator strains of mouse teratocarcinoma.
Molecular & general genetics : MGG 1987;208(1-2):342-8.
1987: Gerard D Schellenberg; Samir S Deeb; M Boehnke; E M Bryant; George M Martin; T H Lampe; Thomas D Bird
Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type.
Journal of neurogenetics 1987;4(2-3):97-108.
1987: George M Martin
Interactions of aging and environmental agents: the gerontological perspective.
Progress in clinical and biological research 1987;228():25-80.
1987: G D Zitnik; George M Martin
Murine "housekeeping" enzyme (genetic locus: Idh-1) is regulated in an allele-specific manner.
Developmental genetics 1987;8(3):135-50.
1986: J Starr; S Sela; C M Disteche; P S Rabinovitch; C E Ogburn; A C Smith; George M Martin
Resistance to paraquat in a mammalian cell line.
Somatic cell and molecular genetics 1986;12(2):141-52.
1986: Mitchell S Turker; Jay A Tischfield; P Rabinovitch; Peter J Stambrook; J J Trill; A C Smith; Charles E Ogburn; George M Martin
Differentiation alters the unstable expression of adenine phosphoribosyltransferase in mouse teratocarcinoma cells.
Journal of experimental pathology 1986;2(4):299-311.
1985: Mitchell S Turker; George M Martin
Induction of adenine salvage in mouse cell lines deficient in adenine phosphoribosyltransferase.
Molecular and cellular biology 1985;5(10):2662-8.
1985: K Subba Rao; George M Martin; L A Loeb
Fidelity of DNA polymerase-beta in neurons from young and very aged mice.
Journal of neurochemistry 1985;45(4):1273-8.
1985: S Aizawa; M Ohashi; L A Loeb; George M Martin
Multipotent mutator strain of mouse teratocarcinoma cells.
Somatic cell and molecular genetics 1985;11(3):211-6.
1985: George M Martin; A C Smith; D J Ketterer; C E Ogburn; C M Disteche
Increased chromosomal aberrations in first metaphases of cells isolated from the kidneys of aged mice.
Israel journal of medical sciences 1985;21(3):296-301.
1985: Mitchell S Turker; Charles E Ogburn; George M Martin
Subpopulations of fibroblasts from mouse skeletal muscle defined by clonal variation for 5' nucleotidase expression.
Journal of cellular physiology 1985;122(2):171-7.
1985: J R Silber; M Fry; George M Martin; L A Loeb
Fidelity of DNA polymerases isolated from regenerating liver chromatin of aging Mus musculus.
The Journal of biological chemistry 1985;260(2):1304-10.
1985: D Salk; K Au; H Hoehn; George M Martin
Cytogenetic aspects of Werner syndrome.
Advances in experimental medicine and biology 1985;190():541-6.
1985: D Salk; E Bryant; H Hoehn; P Johnston; George M Martin
Growth characteristics of Werner syndrome cells in vitro.
Advances in experimental medicine and biology 1985;190():305-11.
1985: George M Martin
Genetics and aging; the Werner syndrome as a segmental progeroid syndrome.
Advances in experimental medicine and biology 1985;190():161-70.
1984: P L Horn; Mitchell S Turker; Charles E Ogburn; Christine M Disteche; George M Martin
A cloning assay for 6-thioguanine resistance provides evidence against certain somatic mutational theories of aging.
Journal of cellular physiology 1984;121(2):309-15.
1984: M Fry; J Silber; L A Loeb; George M Martin
Delayed and reduced cell replication and diminishing levels of DNA polymerase-alpha in regenerating liver of aging mice.
Journal of cellular physiology 1984;118(3):225-32.
1984: George M Martin; Charles E Ogburn; K Au; Christine M Disteche
Altered differentiation, indefinite growth potential, diminished tumorigenicity, and suppressed chimerization potential of hybrids between mouse teratocarcinoma cells and thymocytes.
Journal of experimental pathology 1984;1(2):103-33.
1984: Mitchell S Turker; A C Smith; George M Martin
High frequency "switching" at the adenine phosphoribosyltransferase locus in multipotent mouse teratocarcinoma stem cells.
Somatic cell and molecular genetics 1984;10(1):55-69.
1983: S Aizawa; L A Loeb; George M Martin
Mouse teratocarcinoma cells resistant to aphidicolin and arabinofuranosyl cytosine: isolation and initial characterization.
Journal of cellular physiology 1983;115(1):9-14.
1983: P K Liu; C C Chang; James E Trosko; D K Dube; George M Martin; L A Loeb
Mammalian mutator mutant with an aphidicolin-resistant DNA polymerase alpha.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(3):797-801.
1983: George M Martin; C E Ogburn; T N Wight
Comparative rates of decline in the primary cloning efficiencies of smooth muscle cells from the aging thoracic aorta of two murine species of contrasting maximum life span potentials.
The American journal of pathology 1983;110(2):236-45.
1983: E M Bryant; George M Martin; H Hoehn
Fragile X expression studied by clonal analysis and somatic cell hybridization.
Cytogenetics and cell genetics 1983;35(3):223-5.
1982: William R Pendergrass; A C Saulewicz; G C Burmer; P S Rabinovitch; Thomas H Norwood; George M Martin
Evidence that a critical threshold of DNA polymerase-alpha activity may be required for the initiation of DNA synthesis in mammalian cell heterokaryons.
Journal of cellular physiology 1982;113(1):141-51.
1982: P S Rabinovitch; George M Martin
Encephalomyocarditis virus as a probe of errors in macromolecular synthesis in aging mice.
Mechanisms of ageing and development 1982;20(2):155-63.
1982: P Johnston; D Salk; George M Martin; H Hoehn
Cultivated cells from mid-trimester amniotic fluids: IV. Cell type indentification via one and two-dimensional electrophoresis of clonal whole cell homogenates.
Prenatal diagnosis 1982;2(2):79-88.
1982: P S Rabinovitch; George M Martin; H Hoehn
Interphase flow-cytogenetics: correlation of DNA fluorescence to aneuploidy in human fibroblast cultures.
Human genetics 1982;61(3):246-9.
1982: George M Martin; T Kirkwood; M Fry; S Goldstein; W T Brown; D Salk
Workshop on aging and genetics.
Progress in clinical and biological research 1982;103 Pt A():339-42.
1982: George M Martin
Syndromes of accelerated aging.
National Cancer Institute monograph 1982;60():241-7.
1981: A O Martinez; T H Norwood; George M Martin
Growth inhibition and morphologic modulation of human fibroblastlike cells by erythromycin.
In vitro 1981;17(11):979-84.
1981: S Kim; George M Martin
Preparation of cell-size unilamellar liposomes with high captured volume and defined size distribution.
Biochimica et biophysica acta 1981;646(1):1-9.
1981: M Fry; L A Loeb; George M Martin
On the activity and fidelity of chromatin-associated hepatic DNA polymerase-beta in aging murine species of different life spans.
Journal of cellular physiology 1981;106(3):435-44.
1981: D Salk; E Bryant; K Au; H Hoehn; George M Martin
Systematic growth studies, cocultivation, and cell hybridization studies of Werner syndrome cultured skin fibroblasts.
Human genetics 1981;58(3):310-6.
1981: D Salk; K Au; H Hoehn; George M Martin
Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism.
Cytogenetics and cell genetics 1981;30(2):92-107.
1981: D Salk; K Au; H Hoehn; M R Stenchever; George M Martin
Evidence of clonal attenuation, clonal succession, and clonal expansion in mass cultures of aging Werner's syndrome skin fibroblasts.
Cytogenetics and cell genetics 1981;30(2):108-17.
1981: D Salk; K Au; H Hoehn; George M Martin
Effects of radical-scavenging enzymes and reduced oxygen exposure on growth and chromosome abnormalities of Werner syndrome cultured skin fibroblasts.
Human genetics 1981;57(3):269-75.
1980: M Fry; C W Shearman; George M Martin; L A Loeb
On the fidelity of deoxyribonucleic acid synthesis directed by chromatin-associated deoxyribonucleic acid polymerase beta.
Biochemistry 1980;19(25):5939-46.
1980: H Hoehn; M Simpson; E M Bryant; P S Rabinovitch; D Salk; George M Martin
Effects of chromosome constitution on growth and longevity of human skin fibroblast cultures.
American journal of medical genetics 1980;7(2):141-54.
1980: George M Martin; H Hoehn; E M Bryant
Evidence against somatic mutation as a mechanism of clonal senescence.
Advances in experimental medicine and biology 1980;129():139-45.
1980: George M Martin
Genotropic theories of aging: an overview.
Advances in pathobiology 1980;7():5-20.
1979: T H Norwood; H Hoehn; D Salk; George M Martin
Cellular aging in Werner's syndrome: a unique phenotype?
The Journal of investigative dermatology 1979;73(1):92-6.
1979: A S Lubiniecki; William A Blattner; George M Martin; P J Fialkow; H Dosik; C Eatherly; Joseph Fraumeni
SV40 T-antigen expression in cultured fibroblasts from patients with Down syndrome and their parents.
American journal of human genetics 1979;31(4):469-77.
1979: E M Bryant; H Hoehn; George M Martin
Normalisation of sister chromatid exchange frequencies in Bloom's syndrome by euploid cell hybridisation.
Nature 1979;279(5716):795-6.
1979: George M Martin
Genetic and evolutionary aspects of aging.
Federation proceedings 1979;38(6):1962-7.
1979: T H Norwood; W Pendergrass; P Bornstein; George M Martin
DNA synthesis of sublethally injured cells in heterokaryons and its relevance to clonal senescence.
Experimental cell research 1979;119(1):15-21.
1979: George M Martin
Proliferative homeostasis and its age-related aberrations.
Mechanisms of ageing and development 1979;9(5-6):385-91.
1978: A O Martinez; T H Norwood; J W Prothero; George M Martin
Evidence for clonal attenuation of growth potential in HeLa cells.
In vitro 1978;14(12):996-1002.
1978: E M Bryant; E Crouch; P Bornstein; George M Martin; P Johnston; H Hoehn
Regulation of growth and gene activity in euploid hybrids between human neonatal fibroblasts and epithelioid amniotic fluid cells.
American journal of human genetics 1978;30(4):392-405.
1978: H Hoehn; E M Bryant; George M Martin
The replicative life spans of euploid hybrids derived from short-lived and long-lived human skin fibroblast cultures.
Cytogenetics and cell genetics 1978;21(5):282-95.
1978: George M Martin
Genetic syndromes in man with potential relevance to the pathobiology of aging.
Birth defects original article series 1978;14(1):5-39.
1977: George M Martin
Cellular aging--postreplicative cells. A review (Part II).
The American journal of pathology 1977;89(2):513-30.
1977: George M Martin
Cellular aging--clonal senescence. A review (Part I).
The American journal of pathology 1977;89(2):484-512.
1977: George M Martin
Presentation of the Rous-Whipple Award to Richmond T. Prehn, MD.
The American journal of pathology 1977;88(1):2-4.
1977: R E Anderson; E S Benson; D Korn; George M Martin; S L Robbins; D G Scarpelli; R E Scully; W M Thurlebeck; B M Wagner; S I Zacks
Carcinogenesis testing and the pathologist.
Human pathology 1977;8(3):353-4.
1977: R H Ruvalcaba; S Churesigaew; S A Myhre; V C Kelley; George M Martin
Children who age rapidly--progeroid syndromes: case report of a new variant.
Clinical pediatrics 1977;16(3):248-52.
1977: H Hoehn; K Au; L E Karp; George M Martin
Somatic stability of variant C-band heterochromatin.
Human genetics 1977;35(2):163-8.
1976: T H Norwood; C J Zeigler; George M Martin
Dimethyl sulfoxide enhances polyethylene glycol-mediated somatic cell fusion.
Somatic cell genetics 1976;2(3):263-70.
1976: W R Pendergrass; George M Martin; P Bornstein
Evidence contrary to the protein error hypothesis for in vitro senescence.
Journal of cellular physiology 1976;87(1):3-13.
1975: H Hoehn; E M Bryant; P Johnston; T H Norwood; George M Martin
Non-selective isolation, stability and longevity of hybrids between normal human somatic cells.
Nature 1975;258(5536):608-10.
1975: H Hoehn; E M Bryant; A G Fantel; George M Martin
Cultivated cells from diagnostic amniocentesis in second trimester pregnancies. III. The fetal urine as a potential source of clonable cells.
Humangenetik 1975;29(4):285-90.
1975: T H Norwood; W R Pendergrass; George M Martin
Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential.
The Journal of cell biology 1975;64(3):551-6.
1975: H Hoehn; E M Bryant; K Au; T H Norwood; H Boman; George M Martin
Variegated translocation mosaicism in human skin fibroblast cultures.
Cytogenetics and cell genetics 1975;15(5):282-98.
1975: H Hoehn; E M Bryant; L E Karp; George M Martin
Cultivated cells from diagnostic amniocentesis in second trimester pregnancies. II. Cytogenetic parameters as functions of clonal type and preparative technique.
Clinical genetics 1975;7(1):29-36.
1975: George M Martin; C Ogburn; C Sprague
Senescence and vascular disease.
Advances in experimental medicine and biology 1975;61():163-93.
1975: George M Martin; C A Sprague; T H Norwood; W R Pendergrass; P Bornstein; H Hoehn; W P Arend
Do hyperplastoid cell lines "differentiate themselves to death"?
Advances in experimental medicine and biology 1975;53():67-90.
1974: H Hoehn; E M Bryant; L E Karp; George M Martin
Cultivated cells from diagnostic amniocentesis in second trimester pregnancies. I. Clonal morphology and growth potential.
Pediatric research 1974;8(8):746-54.
1974: George M Martin; H Hoehn
Genetics and human disease.
Human pathology 1974;5(4):387-405.
1974: T H Norwood; W R Pendergrass; C A Sprague; George M Martin
Dominance of the senescent phenotype in heterokaryons between replicative and post-replicative human fibroblast-like cells.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(6):2231-5.
1974: G C Boffey; George M Martin
A new solvent system for the thin-layer chromatographic separation of the Dansyl derivatives of some biogenic amines.
Journal of chromatography 1974;90(1):178-80.
1974: C A Sprague; H Hoehn; George M Martin
Ploidy of living clones of human somatic cells determined by mensuration at metaphase.
The Journal of cell biology 1974;60(3):781-4.
1974: George M Martin; C A Sprague; T H Norwood; W R Pendergrass
Clonal selection, attenuation and differentiation in an in vitro model of hyperplasia.
The American journal of pathology 1974;74(1):137-54.
1973: D M Purnell; George M Martin
A morphologic mutation in Aspergillus nidulans associated with increased virulence for mice.
Mycopathologia et mycologia applicata 1973;51(1):75-9.
1973: H Hoehn; George M Martin
Clonal variants of constitutive heterochromatin of human fibroblasts after recovery from mitomycin treatment.
Chromosoma 1973;43(2):203-10.
1973: P J Fialkow; George M Martin; C A Sprague
Replicative life-span of cultured skin fibroblasts from young mothers of subjects with Down's syndrome: failure to detect accelerated ageing.
American journal of human genetics 1973;25(3):317-22.
1973: D M Purnell; George M Martin
Heterozygous diploid strains of Aspergillus nidulans: enhanced virulence for mice in comparison to a prototrophic haploid strain.
Mycopathologia et mycologia applicata 1973;49(4):307-19.
1973: George M Martin; C A Sprague
Symposium on in vitro studies related to atherogenesis. Life histories of hyperplastoid cell lines from aorta and skin.
Experimental and molecular pathology 1973;18(2):125-41.
1973: H Hoehn; George M Martin
Nonrandom arrangement of human chromatin: topography of disomic markers X, Y, and 1h plus 1.
Cytogenetics and cell genetics 1973;12(6):443-52.
1973: H Hoehn; C A Sprague; George M Martin
Effects of cytochalasin B on cultivated human diploid fibroblasts and its use for the isolation of tetraploid clones.
Experimental cell research 1973;76(1):170-4.
1972: George M Martin; C A Sprague
Clonal senescence and atherosclerosis.
Lancet 1972;2(7791):1370-1.
1972: H Hoehn; George M Martin
Heritable alteration of human constitutive heterochromatin induced by mitomycin C.
Experimental cell research 1972;75(1):275-8.
1972: P J Fialkow; George M Martin; G Klein; P Clifford; S Singh
Evidence for a clonal origin of head and neck tumors.
International journal of cancer. Journal international du cancer 1972;9(1):133-42.
1971: D M Purnell; George M Martin
Aspergillus nidulans: association of certain alkaline phosphatase mutations with decreased virulence for mice.
The Journal of infectious diseases 1971;123(3):305-6.
1970: George M Martin; C A Sprague
Vinblastine induces multipolar mitoses in tetraploid human cells.
Experimental cell research 1970;63(2):466-7.
1970: George M Martin; B R Schwartz; M A Derr
Human lymphoid cell lines: potential hazards to laboratory workers.
Lancet 1970;2(7676):772.
1970: George M Martin; C A Sprague; C J Epstein
Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.
Laboratory investigation; a journal of technical methods and pathology 1970;23(1):86-92.
1970: C A Sprague; P W Kohnen; George M Martin
Sirenomelia. Chromosomal breaks and abnormal associations in cultures from the fused lower limb.
Archives of pathology 1970;90(1):29-30.
1969: George M Martin
Nutrition and cancer.
Lancet 1969;2(7628):1014.
1969: George M Martin; C A Sprague
Parasexual cycle in cultivated human somatic cells.
Science (New York, N.Y.) 1969;166(3906):761-3.
1969: George M Martin; M A Derr; C A Sprague
Alkaline phosphatase constitutivity: a marker for the estimation of somatic cell "mutation" in man.
Annals of the New York Academy of Sciences 1969;166(2):433-46.
1967: George M Martin; C Sprague; J S Bryant
Mitotic nondisjunction in cultivated human cells.
Nature 1967;214(5088):612-3.
1967: G J Todaro; George M Martin
Increased susceptibility of Down's syndrome fibroblasts to transformation by SV40.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1967;124(4):1232-6.
1967: G L Dorn; George M Martin; D M Purnell
Genetic and cytoplasmic control of undifferentiated growth in Aspergillus nidulans.
Life sciences 1967;6(6):629-33.
1967: T G Papayannopoulou; George M Martin
Alkaline phosphatase "constitutive" clones: evidence for de-novo heterogeneity of established human skin fibroblast strains.
Experimental cell research 1967;45(1):72-84.
1966: R M Loder; George M Martin
Establishment of human skin fibroblast cultures with an automatic wedge biopsy instrument.
The Journal of investigative dermatology 1966;47(6):603-5.
1966: George M Martin
Clonal variation of derepressed phosphatase in chromosomally mosaic cell cultures from a child with Down's syndrome.
Experimental cell research 1966;44(2):341-50.
1966: H Platter; George M Martin
Tryptophane transport in cultures of human fibroblasts.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1966;123(1):140-3.
1966: George M Martin; A Tuan
A definitive cloning technique for human fibroblast cultures.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1966;123(1):138-40.
1966: George M Martin
Hazards of inactivity.
JAMA : the journal of the American Medical Association 1966;196(10):909-10.
1966: C J Epstein; George M Martin; A L Schultz; A G Motulsky
Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process.
Medicine 1966;45(3):177-221.
1966: George M Martin; C Sprague; W B Dunham
Chromosomal analysis of "leukocyte" cell lines.
Laboratory investigation; a journal of technical methods and pathology 1966;15(4):692-9.
1965: C J Epstein; George M Martin; A G Motulsky
Werner's syndrome; caricature of aging. A genetic model for the study of degenerative diseases.
Transactions of the Association of American Physicians 1965;78():73-81.
1964: George M Martin
ALKALINE PHOSPHATASE OF HUMAN SKIN FIBROBLAST CULTURES. II. KINETICS OF VARIOUS "INDUCTIONS".
Experimental and molecular pathology 1964;90():634-47.
1964: George M Martin
ALKALINE PHOSPHATASE OF HUMAN SKIN FIBROBLAST CULTURES. I. A MICROASSAY DEMONSTRATING STRAIN VARIATION.
Experimental and molecular pathology 1964;90():622-33.
1964: George M Martin
VARIATION OF ALKALINE PHOSPHATASE ACTIVITY AMONG CELLS OF INDUCIBLE AND CONSTITUTIVE STRAINS OF HUMAN FIBROBLASTS.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1964;116():490-3.
1964: George M Martin
COPPER CONTENT OF HAIR AND NAILS OF NORMAL INDIVIDUALS AND OF PATIENTS WITH HEPATOLENTICULAR DEGENERATION.
Nature 1964;202():903-4.
1964: George M Martin
USE OF TRIS(HYDROXYMETHYL)AMINOMETHANE BUFFERS IN CULTURES OF DIPLOID HUMAN FIBROBLASTS.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1964;116():167-71.
1964: George M Martin
CULTURE OF REPLICATE MONOLAYERS OF FIBROBLASTS UNDER IDENTICAL CONDITIONS.
Nature 1964;201():1338-40.
1964: George M Martin; M A DERR; E P BENDITT
CERULOPLASMINS OF SEVERAL ANIMAL SPECIES. COMPARISON OF ELECTROPHORETIC MOBILITIES AND SUBSTRATE SPECIFICITY.
Laboratory investigation; a journal of technical methods and pathology 1964;13():282-7.
1962: J F AFONSO; George M Martin; F S NISCO; R R DE ALVAREZ
Melanogenic ovarian tumors.
American journal of obstetrics and gynecology 1962;84():667-76.
1961: R MCALISTER; George M Martin; E P BENDITT
Evidence for multiple caeruloplasmin components in human serum.
Nature 1961;190():927-9.
1960: George M Martin; E P BENDITT; N ERIKSEN
Enzymic oxidation of the indole nucleus of 5-hydroxytryptamine: properties of an enzyme in human serum and of the products of oxidation.
Archives of biochemistry and biophysics 1960;90():208-17.
1960: George M Martin; E P BENDITT; N ERIKSEN
Vanadium catalysis of the oxidation of catechol amines, dihydroxyphenylalanine and 5-hydroxyindoles.
Nature 1960;186():884-5.
1960: N ERIKSEN; George M Martin; E P BENDITT
Oxidation of the indole nucleus of 5-hydroxytryptamine and the formation of pigments: isolation and partial characterization of a dimer of 5-hydroxytryptamine.
The Journal of biological chemistry 1960;235():1662-7.