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Juan Martín

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Carlos Barreiro; Sven Brand; Eva González-Lavado; Andreas Tauch; Juan F Martín
Heat Shock Proteome Analysis of Wild-Type Corynebacterium glutamicum ATCC 13032 and a Spontaneous Mutant Lacking GroEL1, a Dispensable Chaperone.
Marta Fernández-Aguado; Raquel Rodríguez-Castro; Fernando Teijeira; Ricardo V Ullán; Juan F Martín
The transport of phenylacetic acid across the peroxisomal membrane is mediated by the PaaT protein in Penicillium chrysogenum.
Mónica Barriuso-Iglesias; Carlos Barreiro; Alberto Sola-Landa; Juan F Martín
Transcriptional control of the F0F1-ATP synthase operon of Corynebacterium glutamicum: SigmaH factor binds to its promoter and regulates its expression at different pH values.

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2013: Carlos Barreiro; Sven Brand; Eva González-Lavado; Andreas Tauch; Juan F Martín
Heat Shock Proteome Analysis of Wild-Type Corynebacterium glutamicum ATCC 13032 and a Spontaneous Mutant Lacking GroEL1, a Dispensable Chaperone.
Journal of bacteriology 2013;195(11):2707.
2013: Marta Fernández-Aguado; Raquel Rodríguez-Castro; Fernando Teijeira; Ricardo V Ullán; Juan F Martín
The transport of phenylacetic acid across the peroxisomal membrane is mediated by the PaaT protein in Penicillium chrysogenum.
Applied microbiology and biotechnology 2013;97(7):3073-84.
2013: Mónica Barriuso-Iglesias; Carlos Barreiro; Alberto Sola-Landa; Juan F Martín
Transcriptional control of the F0F1-ATP synthase operon of Corynebacterium glutamicum: SigmaH factor binds to its promoter and regulates its expression at different pH values.
Microbial biotechnology 2013;6(2):178-88.
2013: Alberto Sola-Landa; Wolfgang Wohlleben; Rafat Amin; Antonio Rodríguez-García; Juan F Martín
Competition between the GlnR and PhoP regulators for the glnA and amtB promoters in Streptomyces coelicolor.
Nucleic acids research 2013;41(3):1767-82.
2013: Fernando Santos-Beneit; Antonio Rodríguez-García; Juan F Martín
Identification of different promoters in the absA1-absA2 two-component system, a negative regulator of antibiotic production in Streptomyces coelicolor.
Molecular genetics and genomics : MGG 2013;288(1-2):39-48.
2013: V Robles-Reglero; Irene Santamarta; R Álvarez-Álvarez; Juan F Martín; Paloma Liras
Transcriptional analysis and proteomics of the holomycin gene cluster in overproducer mutants of Streptomyces clavuligerus.
Journal of biotechnology 2013;163(1):69-76.
2013: Paula Yagüe; María T López-García; Juan F Martín; Beatriz Rioseras; Antonio Rodríguez-García; Jesús Sánchez; Angel Manteca
Transcriptomic analysis of Streptomyces coelicolor differentiation in solid sporulating cultures: first compartmentalized and second multinucleated mycelia have different and distinctive transcriptomes.
PloS one 2013;8(3):e60665.
2013: Marta Fernández-Aguado; Juan F Martín; Fernando Teijeira; Ricardo V Ullán
A vacuolar membrane protein affects drastically the biosynthesis of the ACV tripeptide and the beta-lactam pathway of Penicillium chrysogenum.
Applied microbiology and biotechnology 2013;97(2):795-808.
2012: Jorge Martín; Silvia María Albillos; Carlos García-Estrada; K Kosalková; Ricardo V Ullán; Juan F Martín
The inducers 1,3-diaminopropane and spermidine produce a drastic increase in the expression of the penicillin biosynthetic genes for prolonged time, mediated by the laeA regulator.
Fungal genetics and biology : FG & B 2012;49(12):1004-13.
2012: Rebeca Domínguez-Santos; K Kosalková; Juan F Martín; Carlos Prieto; Ricardo V Ullán; Carlos García-Estrada
The regulatory factor PcRFX1 controls the expression of the three genes of β-lactam biosynthesis in Penicillium chrysogenum.
Fungal genetics and biology : FG & B 2012;49(11):866-81.
2012: Fernando Santos-Beneit; Antonio Rodríguez-García; Juan F Martín
Overlapping binding of PhoP and AfsR to the promoter region of glnR in Streptomyces coelicolor.
Microbiological research 2012;167(9):532-5.
2012: Carlos Barreiro; Lorena T Fernández-Martínez; Carlos García-Estrada; Jesus Aparicio; Miriam Martínez-Castro; Rosario Pérez-Redondo; Carlos Prieto; Antonio Rodríguez-García; Zahra Salehi-Najafabadi; Santos-aberturas Javier; Alberto Sola-Landa; Elena Solera; Andreas Tauch; Juan F Martín
Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506).
Journal of bacteriology 2012;194(14):3756-7.
2012: Lorena T Fernández-Martínez; Fernando Santos-Beneit; Juan F Martín
Is PhoR-PhoP partner fidelity strict? PhoR is required for the activation of the pho regulon in Streptomyces coelicolor.
Molecular genetics and genomics : MGG 2012;287(7):565-73.
2012: Juan F Martín; Kay Nieselt; Antonio Rodríguez-García; Fernando Santos-Beneit; Margaret C M Smith; Alberto Sola-Landa; Nigel J Burroughs; Trond E Ellingsen; Elizabeth M H Wellington
Transcriptomic studies of phosphate control of primary and secondary metabolism in Streptomyces coelicolor.
Applied microbiology and biotechnology 2012;95(1):61-75.
2012: Dušan Goranovič; Jaka Horvat; Gregor Kopitar; Gregor Kosec; Enej Kuščer; Vasilka Magdevska; Juan F Martín; Miriam Martínez-Castro; Peter Mrak; Carlos Barreiro; Marko Blažič; Stefan Fujs; Tomaž Polak; Santos-aberturas Javier; Hrvoje Petković
FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis.
BMC microbiology 2012;12():238.
2012: Juan F Martín; Paloma Liras
Cascades and networks of regulatory genes that control antibiotic biosynthesis.
Sub-cellular biochemistry 2012;64():115-38.
2012: Santos-aberturas Javier; Cláudia M Vicente; Carmen Cañibano; Juan F Martín; Lara Martín-Sánchez; Tamara D Payero; Jesus Aparicio
Hierarchical control on polyene macrolide biosynthesis: PimR modulates pimaricin production via the PAS-LuxR transcriptional activator PimM.
PloS one 2012;7(6):e38536.
2012: Rosario Pérez-Redondo; Antonio Rodríguez-García; Irene Santamarta; Alma Botas; Juan F Martín; Paloma Liras
ArgR of Streptomyces coelicolor is a versatile regulator.
PloS one 2012;7(3):e32697.
2012: Carlos Barreiro; Juan F Martín; Carlos García-Estrada
Proteomics shows new faces for the old penicillin producer Penicillium chrysogenum.
Journal of biomedicine & biotechnology 2012;2012():105109.
2012: Katarina Kosalková; Miguel A Paniagua; Carlos Barreiro; Martha G Flórez; Carlos García-Estrada; Mohammad S Jami; Juan F Martín
Casein phosphopeptides drastically increase the secretion of extracellular proteins in Aspergillus awamori. Proteomics studies reveal changes in the secretory pathway.
Microbial cell factories 2012;11():5.
2011: Zahra Salehi-Najafabadi; Elena Solera; Carlos Barreiro; Miriam Martínez-Castro; Juan F Martín
Characterisation of a γ-butyrolactone receptor of Streptomyces tacrolimicus: effect on sporulation and tacrolimus biosynthesis.
Applied microbiology and biotechnology 2011;92(5):971-84.
2011: Carlos García-Estrada; Silvia María Albillos; Pawel Durek; María Ángeles Fernández-Bodega; Ricardo V Ullán; Hans von Döhren; Juan F Martín
A single cluster of coregulated genes encodes the biosynthesis of the mycotoxins roquefortine C and meleagrin in Penicillium chrysogenum.
Chemistry & biology 2011;18(11):1499-512.
2011: Santos-aberturas Javier; Cláudia M Vicente; Carmen Cañibano; Susana M Guerra; Juan F Martín; Tamara D Payero; Jesus Aparicio
Functional conservation of PAS-LuxR transcriptional regulators in polyene macrolide biosynthesis.
Metabolic engineering 2011;13(6):756-67.
2011: Fernando Santos-Beneit; Alberto Sola-Landa; Mónica Barriuso-Iglesias; Lorena T Fernández-Martínez; Miriam Martínez-Castro; Antonio Rodríguez-García; Juan F Martín
The RNA polymerase omega factor RpoZ is regulated by PhoP and has an important role in antibiotic biosynthesis and morphological differentiation in Streptomyces coelicolor.
Applied and environmental microbiology 2011;77(21):7586-94.
2011: F Teijeira; Ricardo V Ullán; M Fernández-Aguado; Juan F Martín
CefR modulates transporters of beta-lactam intermediates preventing the loss of penicillins to the broth and increases cephalosporin production in Acremonium chrysogenum.
Metabolic engineering 2011;13(5):532-43.
2011: Irene Santamarta; R Alvarez-Álvarez; A Kurt; M T López-García; Juan F Martín; N Nárdiz; Rosario Pérez-Redondo; Paloma Liras
Characterization of DNA-binding sequences for CcaR in the cephamycin-clavulanic acid supercluster of Streptomyces clavuligerus.
Molecular microbiology 2011;81(4):968-81.
2011: Inmaculada Vaca; Javier Casqueiro; Renato Chávez; Angel Rumbero; Ricardo V Ullán; Juan F Martín
A preparative method for the purification of isopenicillin N from genetically blocked Acremonium chrysogenum strain TD189: studies on the degradation kinetics and storage conditions.
The Journal of antibiotics 2011;64(6):447-51.
2011: Fernando Santos-Beneit; Antonio Rodríguez-García; Juan F Martín
Complex transcriptional control of the antibiotic regulator afsS in Streptomyces: PhoP and AfsR are overlapping, competitive activators.
Journal of bacteriology 2011;193(9):2242-51.
2011: Miriam Martínez-Castro; Carlos Barreiro; Francisco Romero; Rosa Isabel Fernández-Chimeno; Juan F Martín
Streptomyces tacrolimicus sp. nov., a low producer of the immunosuppressant tacrolimus (FK506).
International journal of systematic and evolutionary microbiology 2011;61(Pt 5):1084-8.
2011: Santos-aberturas Javier; Cláudia M Vicente; Susana M Guerra; Tamara D Payero; Juan F Martín; Jesus Aparicio
Molecular control of polyene macrolide biosynthesis: direct binding of the regulator PimM to eight promoters of pimaricin genes and identification of binding boxes.
The Journal of biological chemistry 2011;286(11):9150-61.
2011: Nuria Nárdiz; Irene Santamarta; Luis M Lorenzana; Juan F Martín; Paloma Liras
A rhodanese-like protein is highly overrepresented in the mutant S. clavuligerus oppA2::aph: effect on holomycin and other secondary metabolites production.
Microbial biotechnology 2011;4(2):216-25.
2011: Juan F Martín; Alberto Sola-Landa; Fernando Santos-Beneit; Lorena T Fernández-Martínez; Carlos Prieto; Antonio Rodríguez-García
Cross-talk of global nutritional regulators in the control of primary and secondary metabolism in Streptomyces.
Microbial biotechnology 2011;4(2):165-74.
2010: Ricardo V Ullán; Fernando Teijeira; Susana M Guerra; Inmaculada Vaca; Juan F Martín
Characterization of a novel peroxisome membrane protein essential for conversion of isopenicillin N into cephalosporin C.
The Biochemical journal 2010;432(2):227-36.
2010: Juan F Martín; Ricardo V Ullán; Carlos García-Estrada
Regulation and compartmentalization of β-lactam biosynthesis.
Microbial biotechnology 2010;3(3):285-99.
2010: Rosario Pérez-Redondo; Irene Santamarta; Roel Bovenberg; Juan F Martín; Paloma Liras
The enigmatic lack of glucose utilization in Streptomyces clavuligerus is due to inefficient expression of the glucose permease gene.
Microbiology (Reading, England) 2010;156(Pt 5):1527-37.
2009: Franco Teves; Mónica Lamas-Maceiras; Carlos García-Estrada; Javier Casqueiro; Leopoldo Naranjo; Ricardo V Ullán; José-Martín Scervino; Xiaobin Wu; Tania Velasco-Conde; Juan F Martín
Transcriptional upregulation of four genes of the lysine biosynthetic pathway by homocitrate accumulation in Penicillium chrysogenum: homocitrate as a sensor of lysine-pathway distress.
Microbiology (Reading, England) 2009;155(Pt 12):3881-92.
2009: M A Fernández-Bodega; E Mauriz; A Gómez; Juan F Martín
Proteolytic activity, mycotoxins and andrastin A in Penicillium roqueforti strains isolated from Cabrales, Valdeón and Bejes-Tresviso local varieties of blue-veined cheeses.
International journal of food microbiology 2009;136(1):18-25.
2009: Sedef Tunca; Carlos Barreiro; Juan José R Coque; Juan F Martín
Two overlapping antiparallel genes encoding the iron regulator DmdR1 and the Adm proteins control siderophore [correction of sedephore] and antibiotic biosynthesis in Streptomyces coelicolor A3(2).
The FEBS journal 2009;276(17):4814-27.
2009: Miriam Martínez-Castro; Elena Solera; Juan F Martín; Carlos Barreiro
Efficient pyramidal arrangement of an ordered cosmid library: Rapid screening of genes of the tacrolimus-producer Streptomyces sp. ATCC 55098.
Journal of microbiological methods 2009;78(2):150-4.
2009: Fernando Santos-Beneit; Antonio Rodríguez-García; Alexander K Apel; Juan F Martín
Phosphate and carbon source regulation of two PhoP-dependent glycerophosphodiester phosphodiesterase genes of Streptomyces coelicolor.
Microbiology (Reading, England) 2009;155(Pt 6):1800-11.
2009: Antonio Rodríguez-García; Alberto Sola-Landa; Kristian Apel; Fernando Santos-Beneit; Juan F Martín
Phosphate control over nitrogen metabolism in Streptomyces coelicolor: direct and indirect negative control of glnR, glnA, glnII and amtB expression by the response regulator PhoP.
Nucleic acids research 2009;37(10):3230-42.
2009: Fernando Santos-Beneit; Antonio Rodríguez-García; Alberto Sola-Landa; Juan F Martín
Cross-talk between two global regulators in Streptomyces: PhoP and AfsR interact in the control of afsS, pstS and phoRP transcription.
Molecular microbiology 2009;72(1):53-68.
2009: Ramiro Godio Fernández; Juan F Martín
Modified oxidosqualene cyclases in the formation of bioactive secondary metabolites: biosynthesis of the antitumor clavaric acid.
Fungal genetics and biology : FG & B 2009;46(3):232-42.
2009: Fernando Teijeira; Ricardo V Ullán; Susana M Guerra; Carlos García-Estrada; Inmaculada Vaca; Juan F Martín
The transporter CefM involved in translocation of biosynthetic intermediates is essential for cephalosporin production.
The Biochemical journal 2009;418(1):113-24.
2009: Marta Rodríguez-Sáiz; Ramiro Godio Fernández; Vanessa Alvarez; juan luis fuente; Juan F Martín; José Luis Barredo
The NADP-dependent glutamate dehydrogenase gene from the astaxanthin producer Xanthophyllomyces dendrorhous: use of Its promoter for controlled gene expression.
Molecular biotechnology 2009;41(2):165-72.
2009: Cláudia M Vicente; Santos-aberturas Javier; Susana M Guerra; Tamara D Payero; Juan F Martín; Jesus Aparicio
PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis.
Microbial cell factories 2009;8():33.
2009: Carlos García-Estrada; Inmaculada Vaca; Ricardo V Ullán; Marco A van den Berg; Roel A L Bovenberg; Juan F Martín
Molecular characterization of a fungal gene paralogue of the penicillin penDE gene of Penicillium chrysogenum.
BMC microbiology 2009;9():104.
2009: Juan F Martín; Jesus Aparicio
Enzymology of the polyenes pimaricin and candicidin biosynthesis.
Methods in enzymology 2009;459():215-42.
2008: Ramón O García-Rico; Francisco Fierro; Elba Mauriz; Ana Gómez; María Angeles Fernández-Bodega; Juan F Martín
The heterotrimeric Galpha protein pga1 regulates biosynthesis of penicillin, chrysogenin and roquefortine in Penicillium chrysogenum.
Microbiology (Reading, England) 2008;154(Pt 11):3567-78.
2008: Carlos García-Estrada; Ricardo V Ullán; Tania Velasco-Conde; Ramiro Godio Fernández; Fernando Teijeira; Inmaculada Vaca; Raúl Feltrer; Katarina Kosalková; Elba Mauriz; Juan F Martín
Post-translational enzyme modification by the phosphopantetheinyl transferase is required for lysine and penicillin biosynthesis but not for roquefortine or fatty acid formation in Penicillium chrysogenum.
The Biochemical journal 2008;415(2):317-24.
2008: Ricardo V Ullán; Ramiro Godio Fernández; Fernando Teijeira; Inmaculada Vaca; Carlos García-Estrada; Raúl Feltrer; Katarina Kosalkova; Juan F Martín
RNA-silencing in Penicillium chrysogenum and Acremonium chrysogenum: validation studies using beta-lactam genes expression.
Journal of microbiological methods 2008;75(2):209-18.
2008: Ricardo V Ullán; Fernando Teijeira; Juan F Martín
Expression of the Acremonium chrysogenum cefT gene in Penicillum chrysogenum indicates that it encodes an hydrophilic beta-lactam transporter.
Current genetics 2008;54(3):153-61.
2008: Fernando Santos-Beneit; Antonio Rodríguez-García; Etelvina Franco-Domínguez; Juan F Martín
Phosphate-dependent regulation of the low- and high-affinity transport systems in the model actinomycete Streptomyces coelicolor.
Microbiology (Reading, England) 2008;154(Pt 8):2356-70.
2008: Carlos García-Estrada; Inmaculada Vaca; Francisco Fierro; Klaas Sjollema; Marten Veenhuis; Juan F Martín
The unprocessed preprotein form IATC103S of the isopenicillin N acyltransferase is transported inside peroxisomes and regulates its self-processing.
Fungal genetics and biology : FG & B 2008;45(6):1043-52.
2008: Juan P Gomez-Escribano; Juan F Martín; A Hesketh; M J Bibb; Paloma Liras
Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp.
Microbiology (Reading, England) 2008;154(Pt 3):744-55.
2008: Alberto Sola-Landa; Antonio Rodríguez-García; Alexander Kristian Apel; Juan F Martín
Target genes and structure of the direct repeats in the DNA-binding sequences of the response regulator PhoP in Streptomyces coelicolor.
Nucleic acids research 2008;36(4):1358-68.
2008: Mónica Barriuso-Iglesias; Daniela Schluesener; Carlos Barreiro; Ansgar Poetsch; Juan F Martín
Response of the cytoplasmic and membrane proteome of Corynebacterium glutamicum ATCC 13032 to pH changes.
BMC microbiology 2008;8():225.
2008: Juan F Martín; Eduardo Gudiña; José L Barredo
Conversion of beta-carotene into astaxanthin: Two separate enzymes or a bifunctional hydroxylase-ketolase protein?
Microbial cell factories 2008;7():3.
2007: Ramiro Godio Fernández; Roberto Fouces; Juan F Martín
A squalene epoxidase is involved in biosynthesis of both the antitumor compound clavaric acid and sterols in the basidiomycete H. sublateritium.
Chemistry & biology 2007;14(12):1334-46.
2007: Katarina Kosalková; Marta Rodríguez-Sáiz; José Luis Barredo; Juan F Martín
Binding of the PTA1 transcriptional activator to the divergent promoter region of the first two genes of the penicillin pathway in different Penicillium species.
Current genetics 2007;52(5-6):229-37.
2007: Alexander K Apel; Alberto Sola-Landa; Antonio Rodríguez-García; Juan F Martín
Phosphate control of phoA, phoC and phoD gene expression in Streptomyces coelicolor reveals significant differences in binding of PhoP to their promoter regions.
Microbiology (Reading, England) 2007;153(Pt 10):3527-37.
2007: Irene Santamarta; M Teresa López-García; Rosario Pérez-Redondo; Bert Koekman; Juan F Martín; Paloma Liras
Connecting primary and secondary metabolism: AreB, an IclR-like protein, binds the ARE(ccaR) sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production.
Molecular microbiology 2007;66(2):511-24.
2007: Mandira Goswami; Eliseo Recio; Sonia Campoy; Juan F Martín; Juan José R Coque
Environmental significance of O-demethylation of chloroanisoles by soil bacterial isolates as a mechanism that improves the overall biodegradation of chlorophenols.
Environmental microbiology 2007;9(10):2512-21.
2007: Nuria Antón; Santos-aberturas Javier; Marta V Mendes; Susana M Guerra; Juan F Martín; Jesus Aparicio
PimM, a PAS domain positive regulator of pimaricin biosynthesis in Streptomyces natalensis.
Microbiology (Reading, England) 2007;153(Pt 9):3174-83.
2007: Carlos García-Estrada; Inmaculada Vaca; Mónica Lamas-Maceiras; Juan F Martín
In vivo transport of the intermediates of the penicillin biosynthetic pathway in tailored strains of Penicillium chrysogenum.
Applied microbiology and biotechnology 2007;76(1):169-82.
2007: Antonio Rodríguez-García; Carlos Barreiro; Fernando Santos-Beneit; Alberto Sola-Landa; Juan F Martín
Genome-wide transcriptomic and proteomic analysis of the primary response to phosphate limitation in Streptomyces coelicolor M145 and in a DeltaphoP mutant.
Proteomics 2007;7(14):2410-29.
2007: Ramón O García-Rico; Juan F Martín; Francisco Fierro
The pga1 gene of Penicillium chrysogenum NRRL 1951 encodes a heterotrimeric G protein alpha subunit that controls growth and development.
Research in microbiology 2007;158(5):437-46.
2007: Ricardo V Ullán; Sonia Campoy; Javier Casqueiro; Francisco J Fernández; Juan F Martín
Deacetylcephalosporin C production in Penicillium chrysogenum by expression of the isopenicillin N epimerization, ring expansion, and acetylation genes.
Chemistry & biology 2007;14(3):329-39.
2007: Marta V Mendes; Eliseo Recio; Nuria Antón; Susana M Guerra; Santos-aberturas Javier; Juan F Martín; Jesus Aparicio
Cholesterol oxidases act as signaling proteins for the biosynthesis of the polyene macrolide pimaricin.
Chemistry & biology 2007;14(3):279-90.
2007: Marta V Mendes; Sedef Tunca; Nuria Antón; Eliseo Recio; Alberto Sola-Landa; Jesus Aparicio; Juan F Martín
The two-component phoR-phoP system of Streptomyces natalensis: Inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis.
Metabolic engineering 2007;9(2):217-27.
2007: Sedef Tunca; Carlos Barreiro; Alberto Sola-Landa; Juan José R Coque; Juan F Martín
Transcriptional regulation of the desferrioxamine gene cluster of Streptomyces coelicolor is mediated by binding of DmdR1 to an iron box in the promoter of the desA gene.
The FEBS journal 2007;274(4):1110-22.
2007: M Martínez-Valladares; Ramiro Godio Fernández; MP Vara-Del Río; Juan F Martín; Fa Rojo-Vázquez
Expression of the recombinant protein disulphide isomerase of Teladorsagia circumcincta.
Parasite immunology 2007;29(1):47-56.
2006: Eliseo Recio; Jesus Aparicio; Angel Rumbero; Juan F Martín
Glycerol, ethylene glycol and propanediol elicit pimaricin biosynthesis in the PI-factor-defective strain Streptomyces natalensis npi287 and increase polyene production in several wild-type actinomycetes.
Microbiology (Reading, England) 2006;152(Pt 10):3147-56.
2006: Francisco Fierro; Carlos García-Estrada; Nancy I Castillo; Raquel Rodríguez; Tania Velasco-Conde; Juan F Martín
Transcriptional and bioinformatic analysis of the 56.8 kb DNA region amplified in tandem repeats containing the penicillin gene cluster in Penicillium chrysogenum.
Fungal genetics and biology : FG & B 2006;43(9):618-29.
2006: Juan Pablo Gomez-Escribano; Paloma Liras; Agustín Pisabarro; Juan F Martín
An rplKDelta29-PALG-32 mutation leads to reduced expression of the regulatory genes ccaR and claR and very low transcription of the ceaS2 gene for clavulanic acid biosynthesis in Streptomyces clavuligerus.
Molecular microbiology 2006;61(3):758-70.
2006: Antonio Rodríguez-García; Irene Santamarta; Rosario Pérez-Redondo; Juan F Martín; Paloma Liras
Characterization of a two-gene operon epeRA involved in multidrug resistance in Streptomyces clavuligerus.
Research in microbiology 2006;157(6):559-68.
2006: Lorena L Enríquez; Marta V Mendes; Nuria Antón; Sedef Tunca; Susana M Guerra; Juan F Martín; Jesus Aparicio
An efficient gene transfer system for the pimaricin producer Streptomyces natalensis.
FEMS microbiology letters 2006;257(2):312-8.
2006: Vanessa Alvarez; Marta Rodríguez-Sáiz; Fuente Moreno; Eduardo J Gudiña; Ramiro Godio Fernández; Juan F Martín; José Luis Barredo
The crtS gene of Xanthophyllomyces dendrorhous encodes a novel cytochrome-P450 hydroxylase involved in the conversion of beta-carotene into astaxanthin and other xanthophylls.
Fungal genetics and biology : FG & B 2006;43(4):261-72.
2006: Mónica Lamas-Maceiras; Inmaculada Vaca; Esther Rodríguez; Javier Casqueiro; Juan F Martín
Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an aryl-capping enzyme that supplies phenylacetic acid to the isopenicillin N-acyltransferase.
The Biochemical journal 2006;395(1):147-55.
2006: Sonia Campoy; Angel Rumbero; Juan F Martín; Paloma Liras
Characterization of an hyperpigmenting mutant of Monascus purpureus IB1: identification of two novel pigment chemical structures.
Applied microbiology and biotechnology 2006;70(4):488-96.
2006: Nancy Isabel Castillo; Francisco Fierro; Santiago Gutiérrez; Juan F Martín
Genome-wide analysis of differentially expressed genes from Penicillium chrysogenum grown with a repressing or a non-repressing carbon source.
Current genetics 2006;49(2):85-96.
2006: Mónica Barriuso-Iglesias; Carlos Barreiro; Fabio Flechoso; Juan F Martín
Transcriptional analysis of the F0F1 ATPase operon of Corynebacterium glutamicum ATCC 13032 reveals strong induction by alkaline pH.
Microbiology (Reading, England) 2006;152(Pt 1):11-21.
2005: Leopoldo Naranjo; Mónica Lamas-Maceiras; Ricardo V Ullán; Sonia Campoy; Fernando Teijeira; Javier Casqueiro; Juan F Martín
Characterization of the oat1 gene of Penicillium chrysogenum encoding an omega-aminotransferase: induction by L-lysine, L-ornithine and L-arginine and repression by ammonium.
Molecular genetics and genomics : MGG 2005;274(3):283-94.
2005: E M Martín de Valmaseda; Sonia Campoy; Leopoldo Naranjo; Javier Casqueiro; Juan F Martín
Lysine is catabolized to 2-aminoadipic acid in Penicillium chrysogenum by an omega-aminotransferase and to saccharopine by a lysine 2-ketoglutarate reductase. Characterization of the omega-aminotransferase.
Molecular genetics and genomics : MGG 2005;274(3):272-82.
2005: Juan F Martín; Javier Casqueiro; Paloma Liras
Secretion systems for secondary metabolites: how producer cells send out messages of intercellular communication.
Current opinion in microbiology 2005;8(3):282-93.
2005: Alberto Sola-Landa; Antonio Rodríguez-García; Etelvina Franco-Domínguez; Juan F Martín
Binding of PhoP to promoters of phosphate-regulated genes in Streptomyces coelicolor: identification of PHO boxes.
Molecular microbiology 2005;56(5):1373-85.
2005: Irene Santamarta; Rosario Pérez-Redondo; Luis M Lorenzana; Juan F Martín; Paloma Liras
Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus.
Molecular microbiology 2005;56(3):824-35.
2005: Marta V Mendes; Nuria Antón; Juan F Martín; Jesus Aparicio
Characterization of the polyene macrolide P450 epoxidase from Streptomyces natalensis that converts de-epoxypimaricin into pimaricin.
The Biochemical journal 2005;386(Pt 1):57-62.
2005: Francisco J Flores; Carlos Barreiro; Juan José R Coque; Juan F Martín
Functional analysis of two divalent metal-dependent regulatory genes dmdR1 and dmdR2 in Streptomyces coelicolor and proteome changes in deletion mutants.
The FEBS journal 2005;272(3):725-35.
2005: Carlos Barreiro; Eva González-Lavado; Sven Brand; Andreas Tauch; Juan F Martín
Heat shock proteome analysis of wild-type Corynebacterium glutamicum ATCC 13032 and a spontaneous mutant lacking GroEL1, a dispensable chaperone.
Journal of bacteriology 2005;187(3):884-9.
2004: Ricardo V Ullán; Javier Casqueiro; Leopoldo Naranjo; Inmaculada Vaca; Juan F Martín
Expression of cefD2 and the conversion of isopenicillin N into penicillin N by the two-component epimerase system are rate-limiting steps in cephalosporin biosynthesis.
Molecular genetics and genomics : MGG 2004;272(5):562-70.
2004: Ramiro Godio Fernández; R Fouces; E J Gudiña; Juan F Martín
Agrobacterium tumefaciens-mediated transformation of the antitumor clavaric acid-producing basidiomycete Hypholoma sublateritium.
Current genetics 2004;46(5):287-94.
2004: Alvaro de la Fuente; Juan F Martín; Antonio Rodríguez-García; Paloma Liras
Two proteins with ornithine acetyltransferase activity show different functions in Streptomyces clavuligerus: Oat2 modulates clavulanic acid biosynthesis in response to arginine.
Journal of bacteriology 2004;186(19):6501-7.
2004: Eliseo Recio; Angel Colinas; Angel Rumbero; Jesus Aparicio; Juan F Martín
PI factor, a novel type quorum-sensing inducer elicits pimaricin production in Streptomyces natalensis.
The Journal of biological chemistry 2004;279(40):41586-93.
2004: Marta Lombraña; Francisco J Moralejo; Rosa Pinto; Juan F Martín
Modulation of Aspergillus awamori thaumatin secretion by modification of bipA gene expression.
Applied and environmental microbiology 2004;70(9):5145-52.
2004: Juan F Martín
Phosphate control of the biosynthesis of antibiotics and other secondary metabolites is mediated by the PhoR-PhoP system: an unfinished story.
Journal of bacteriology 2004;186(16):5197-201.
2004: Carlos Barreiro; Eva González-Lavado; Miroslav Pátek; Juan F Martín
Transcriptional analysis of the groES-groEL1, groEL2, and dnaK genes in Corynebacterium glutamicum: characterization of heat shock-induced promoters.
Journal of bacteriology 2004;186(14):4813-7.
2004: Jesus Aparicio; Marta V Mendes; Nuria Antón; Eliseo Recio; Juan F Martín
Polyene macrolide antibiotic biosynthesis.
Current medicinal chemistry 2004;11(12):1645-56.
2004: Luis M Lorenzana; Rosario Pérez-Redondo; Irene Santamarta; Juan F Martín; Paloma Liras
Two oligopeptide-permease-encoding genes in the clavulanic acid cluster of Streptomyces clavuligerus are essential for production of the beta-lactamase inhibitor.
Journal of bacteriology 2004;186(11):3431-8.
2004: Francisco J Flores; Juan F Martín
Iron-regulatory proteins DmdR1 and DmdR2 of Streptomyces coelicolor form two different DNA-protein complexes with iron boxes.
The Biochemical journal 2004;380(Pt 2):497-503.
2004: Mónica Fernández; Yolanda Cuadrado; Jesus Aparicio; Juan F Martín
Role of homoserine and threonine pathway intermediates as precursors for the biosynthesis of aminoethoxyvinylglycine in Streptomyces sp. NRRL 5331.
Microbiology (Reading, England) 2004;150(Pt 5):1467-74.
2004: Nuria Antón; Marta V Mendes; Juan F Martín; Jesus Aparicio
Identification of PimR as a positive regulator of pimaricin biosynthesis in Streptomyces natalensis.
Journal of bacteriology 2004;186(9):2567-75.
2004: Yolanda Cuadrado; Mónica Fernández; Eliseo Recio; Jesus Aparicio; Juan F Martín
Characterization of the ask-asd operon in aminoethoxyvinylglycine-producing Streptomyces sp. NRRL 5331.
Applied microbiology and biotechnology 2004;64(2):228-36.
2004: Leopoldo Naranjo; Eva Martín de Valmaseda; Javier Casqueiro; Ricardo V Ullán; Mónica Lamas-Maceiras; Oscar Bañuelos; Juan F Martín
Inactivation of the lys7 gene, encoding saccharopine reductase in Penicillium chrysogenum, leads to accumulation of the secondary metabolite precursors piperideine-6-carboxylic acid and pipecolic acid from alpha-aminoadipic acid.
Applied and environmental microbiology 2004;70(2):1031-9.
2004: Francisco Fierro; Federico Laich; Ramón O García-Rico; Juan F Martín
High efficiency transformation of Penicillium nalgiovense with integrative and autonomously replicating plasmids.
International journal of food microbiology 2004;90(2):237-48.
2004: Juan F Martín; Ricardo V Ullán; Javier Casqueiro
Novel genes involved in cephalosporin biosynthesis: the three-component isopenicillin N epimerase system.
Advances in biochemical engineering/biotechnology 2004;88():91-109.
2003: Oscar Bañuelos; Leopoldo Naranjo; Javier Casqueiro; Santiago Gutiérrez; Juan F Martín
Co-transformation with autonomous replicating and integrative plasmids in Penicillium chrysogenum is highly efficient and leads in some cases to rescue of the intact integrative plasmid.
Fungal genetics and biology : FG & B 2003;40(2):83-92.
2003: Juan F Martín; Carlos Barreiro; Eva González-Lavado; Mónica Barriuso
Ribosomal RNA and ribosomal proteins in corynebacteria.
Journal of biotechnology 2003;104(1-3):41-53.
2003: Sonia Campoy; Flor Pérez; Juan F Martín; Santiago Gutiérrez; Paloma Liras
Stable transformants of the azaphilone pigment-producing Monascus purpureus obtained by protoplast transformation and Agrobacterium-mediated DNA transfer.
Current genetics 2003;43(6):447-52.
2003: Rosa Elena Cardoza; Santiago Gutiérrez; N Ortega; A Colina; Javier Casqueiro; Juan F Martín
Expression of a synthetic copy of the bovine chymosin gene in Aspergillus awamori from constitutive and pH-regulated promoters and secretion using two different pre-pro sequences.
Biotechnology and bioengineering 2003;83(3):249-59.
2003: Francisco J Fernández; Rosa Elena Cardoza; Eduardo Montenegro; Javier Velasco; Santiago Gutiérrez; Juan F Martín
The isopenicillin N acyltransferases of Aspergillus nidulans and Penicillium chrysogenum differ in their ability to maintain the 40-kDa alphabeta heterodimer in an undissociated form.
European journal of biochemistry / FEBS 2003;270(9):1958-68.
2003: Maria José Hijarrubia; Jesus Aparicio; Juan F Martín
Domain structure characterization of the multifunctional alpha-aminoadipate reductase from Penicillium chrysogenum by limited proteolysis. Activation of alpha-aminoadipate does not require the peptidyl carrier protein box or the reduction domain.
The Journal of biological chemistry 2003;278(10):8250-6.
2002: Juan F Martín; Arnold L Demain
Unraveling the methionine-cephalosporin puzzle in Acremonium chrysogenum.
Trends in biotechnology 2002;20(12):502-7.
2002: Alvaro de la Fuente; Luis M Lorenzana; Juan F Martín; Paloma Liras
Mutants of Streptomyces clavuligerus with disruptions in different genes for clavulanic acid biosynthesis produce large amounts of holomycin: possible cross-regulation of two unrelated secondary metabolic pathways.
Journal of bacteriology 2002;184(23):6559-65.
2002: Ricardo V Ullán; G Liu; Javier Casqueiro; Santiago Gutiérrez; Oscar Bañuelos; Juan F Martín
The cefT gene of Acremonium chrysogenum C10 encodes a putative multidrug efflux pump protein that significantly increases cephalosporin C production.
Molecular genetics and genomics : MGG 2002;267(5):673-83.
2002: Maria José Hijarrubia; Jesus Aparicio; Juan F Martín
Nitrate regulation of alpha-aminoadipate reductase formation and lysine inhibition of its activity in Penicillium chrysogenum and Acremonium chrysogenum.
Applied microbiology and biotechnology 2002;59(2-3):270-7.
2002: Francisco J Moralejo; Rosa Elena Cardoza; Santiago Gutierrez; Marta Lombraña; Francisco Fierro; Juan F Martín
Silencing of the aspergillopepsin B (pepB) gene of Aspergillus awamori by antisense RNA expression or protease removal by gene disruption results in a large increase in thaumatin production.
Applied and environmental microbiology 2002;68(7):3550-9.
2002: Irene Santamarta; Antonio Rodríguez-García; Rosario Pérez-Redondo; Juan F Martín; Paloma Liras
CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus.
Journal of bacteriology 2002;184(11):3106-13.
2002: Mónica Fernández; Yolanda Cuadrado; Eliseo Recio; Jesus Aparicio; Juan F Martín
Characterization of the hom-thrC-thrB cluster in aminoethoxyvinylglycine-producing Streptomyces sp. NRRL 5331.
Microbiology (Reading, England) 2002;148(Pt 5):1413-20.
2002: Federico Laich; Francisco Fierro; Juan F Martín
Production of penicillin by fungi growing on food products: identification of a complete penicillin gene cluster in Penicillium griseofulvum and a truncated cluster in Penicillium verrucosum.
Applied and environmental microbiology 2002;68(3):1211-9.
2002: Oscar Bañuelos; Javier Casqueiro; S Steidl; Santiago Gutiérrez; Axel A Brakhage; Juan F Martín
Subcellular localization of the homocitrate synthase in Penicillium chrysogenum.
Molecular genetics and genomics : MGG 2002;266(5):711-9.
2001: M Santos; Laureana Rebordinos; Santiago Gutiérrez; Rosa Elena Cardoza; Juan F Martín; Jesús Manuel Cantoral
Characterization of the gdhA gene from the phytopathogen Botrytis cinerea.
Fungal genetics and biology : FG & B 2001;34(3):193-206.
2001: Javier Velasco; Santiago Gutiérrez; Javier Casqueiro; Francisco Fierro; Sonia Campoy; Juan F Martín
Cloning and characterization of the gene cahB encoding a cephalosporin C acetylhydrolase from Acremonium chrysogenum.
Applied microbiology and biotechnology 2001;57(3):350-6.
2001: K Kosalková; Ana Teresa Marcos; Juan F Martín
A moderate amplification of the mecB gene encoding cystathionine-gamma-lyase stimulates cephalosporin biosynthesis in Acremonium chrysogenum.
Journal of industrial microbiology & biotechnology 2001;27(4):252-8.
2001: Francisco J Moralejo; Adrian J Watson; David J Jeenes; David B Archer; Juan F Martín
A defined level of protein disulfide isomerase expression is required for optimal secretion of thaumatin by Aspegillus awamori.
Molecular genetics and genomics : MGG 2001;266(2):246-53.
2001: AL Leitão; Francisco Enguita; Juan F Martín; J F Santos Oliveira
Effect of exogenous lysine on the expression of early cephamycin C biosynthetic genes and antibiotic production in Nocardia lactamdurans MA4213.
Applied microbiology and biotechnology 2001;56(5-6):670-5.
2001: Marta V Mendes; Eliseo Recio; R Fouces; R Luiten; Juan F Martín; Jesus Aparicio
Engineered biosynthesis of novel polyenes: a pimaricin derivative produced by targeted gene disruption in Streptomyces natalensis.
Chemistry & biology 2001;8(7):635-44.
2001: Oscar Bañuelos; Javier Casqueiro; Santiago Gutiérrez; Juan F Martín
Intrachromosomal recombination after targeted monocopy integration in Penicillium chrysogenum: stabilization of the direct repeats to prevent loss of the inserted gene.
Current genetics 2001;39(4):231-6.
2001: V Hernándo-Rico; Juan F Martín; Irene Santamarta; Paloma Liras
Structure of the ask-asd operon and formation of aspartokinase subunits in the cephamycin producer 'Amycolatopsis lactamdurans'.
Microbiology (Reading, England) 2001;147(Pt 6):1547-55.
2001: R S Moura; Juan F Martín; A Martín; Paloma Liras
Substrate analysis and molecular cloning of the extracellular alkaline phosphatase of Streptomyces griseus.
Microbiology (Reading, England) 2001;147(Pt 6):1525-33.
2001: Carlos Barreiro; Eva González-Lavado; Juan F Martín
Organization and transcriptional analysis of a six-gene cluster around the rplK-rplA operon of Corynebacterium glutamicum encoding the ribosomal proteins L11 and L1.
Applied and environmental microbiology 2001;67(5):2183-90.
2001: G Liu; Javier Casqueiro; Oscar Bañuelos; Rosa Elena Cardoza; Santiago Gutiérrez; Juan F Martín
Targeted inactivation of the mecB gene, encoding cystathionine-gamma-lyase, shows that the reverse transsulfuration pathway is required for high-level cephalosporin biosynthesis in Acremonium chrysogenum C10 but not for methionine induction of the cephalosporin genes.
Journal of bacteriology 2001;183(5):1765-72.
2001: Maria José Hijarrubia; Jesus Aparicio; Javier Casqueiro; Juan F Martín
Characterization of the lys2 gene of Acremonium chrysogenum encoding a functional alpha-aminoadipate activating and reducing enzyme.
Molecular & general genetics : MGG 2001;264(6):755-62.
2001: Ana Teresa Marcos; K Kosalková; Rosa Elena Cardoza; Francisco Fierro; Santiago Gutiérrez; Juan F Martín
Characterization of the reverse transsulfuration gene mecB of Acremonium chrysogenum, which encodes a functional cystathionine-gamma-lyase.
Molecular & general genetics : MGG 2001;264(6):746-54.
2000: Francisco J Moralejo; Rosa Elena Cardoza; Santiago Gutiérrez; H Sisniega; I Faus; Juan F Martín
Overexpression and lack of degradation of thaumatin in an aspergillopepsin A-defective mutant of Aspergillus awamori containing an insertion in the pepA gene.
Applied microbiology and biotechnology 2000;54(6):772-7.
2000: Jesus Aparicio; R Fouces; Marta V Mendes; N Olivera; Juan F Martín
A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis.
Chemistry & biology 2000;7(11):895-905.
2000: Antonio Rodríguez-García; Alvaro de la Fuente; Rosario Pérez-Redondo; Juan F Martín; Paloma Liras
Characterization and expression of the arginine biosynthesis gene cluster of Streptomyces clavuligerus.
Journal of molecular microbiology and biotechnology 2000;2(4):543-50.
2000: Rosa Elena Cardoza; Javier Velasco; Juan F Martín; P Liras
A cephalosporin C acetylhydrolase is present in the cultures of Nocardia lactamdurans.
Applied microbiology and biotechnology 2000;54(3):406-12.
2000: Oscar Bañuelos; Javier Casqueiro; Santiago Gutiérrez; Juan F Martín
Overexpression of the lys1 gene in Penicillium chrysogenum: homocitrate synthase levels, alpha-aminoadipic acid pool and penicillin production.
Applied microbiology and biotechnology 2000;54(1):69-77.
2000: Juan F Martín
Molecular control of expression of penicillin biosynthesis genes in fungi: regulatory proteins interact with a bidirectional promoter region.
Journal of bacteriology 2000;182(9):2355-62.
2000: E Amador; Juan F Martín; J M Castro
A Brevibacterium lactofermentum 16S rRNA gene used as target site for homologous recombination.
FEMS microbiology letters 2000;185(2):199-204.
2000: Carlos Barreiro; Agustín Pisabarro; Juan F Martín
Characterization of the ribosomal rrnD operon of the cephamycin-producer 'Nocardia lactamdurans' shows that this actinomycete belongs to the genus Amycolatopsis.
Systematic and applied microbiology 2000;23(1):15-24.
2000: V K Chary; Fuente Moreno; AL Leitão; Paloma Liras; Juan F Martín
Overexpression of the lat gene in Nocardia lactamdurans from strong heterologous promoters results in very high levels of lysine-6-aminotransferase and up to two-fold increase in cephamycin C production.
Applied microbiology and biotechnology 2000;53(3):282-8.
2000: Marta V Mendes; Jesus Aparicio; Juan F Martín
Complete nucleotide sequence and characterization of pSNA1 from pimaricin-producing Streptomyces natalensis that replicates by a rolling circle mechanism.
Plasmid 2000;43(2):159-65.
2000: K Kosalková; Ana Teresa Marcos; Francisco Fierro; V Hernando-Rico; Santiago Gutiérrez; Juan F Martín
A novel heptameric sequence (TTAGTAA) is the binding site for a protein required for high level expression of pcbAB, the first gene of the penicillin biosynthesis in Penicillium chrysogenum.
The Journal of biological chemistry 2000;275(4):2423-30.
2000: Oscar Bañuelos; Javier Casqueiro; Santiago Gutiérrez; Jorge Riaño; Juan F Martín
The specific transport system for lysine is fully inhibited by ammonium in Penicillium chrysogenum: an ammonium-insensitive system allows uptake in carbon-starved cells.
Antonie van Leeuwenhoek 2000;77(1):91-100.
1999: Rosario Pérez-Redondo; Antonio Rodríguez-García; Juan F Martín; Paloma Liras
Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: evidence for two different genes in formation of the C3 unit.
Journal of bacteriology 1999;181(22):6922-8.
1999: Javier Casqueiro; Oscar Bañuelos; Santiago Gutiérrez; Maria José Hijarrubia; Juan F Martín
Intrachromosomal recombination between direct repeats in Penicillium chrysogenum: gene conversion and deletion events.
Molecular & general genetics : MGG 1999;261(6):994-1000.
1999: Jesus Aparicio; A J Colina; E Ceballos; Juan F Martín
The biosynthetic gene cluster for the 26-membered ring polyene macrolide pimaricin. A new polyketide synthase organization encoded by two subclusters separated by functionalization genes.
The Journal of biological chemistry 1999;274(15):10133-9.
1999: E Amador; J M Castro; A Correia; Juan F Martín
Structure and organization of the rrnD operon of 'Brevibacterium lactofermentum': analysis of the 16S rRNA gene.
Microbiology (Reading, England) 1999;145 ( Pt 4)():915-24.
1999: Santiago Gutiérrez; Ana Teresa Marcos; Javier Casqueiro; K Kosalková; Francisco J Fernández; Javier Velasco; Juan F Martín
Transcription of the pcbAB, pcbC and penDE genes of Penicillium chrysogenum AS-P-78 is repressed by glucose and the repression is not reversed by alkaline pHs.
Microbiology (Reading, England) 1999;145 ( Pt 2)():317-24.
1999: Javier Casqueiro; Santiago Gutiérrez; Oscar Bañuelos; Maria José Hijarrubia; Juan F Martín
Gene targeting in Penicillium chrysogenum: disruption of the lys2 gene leads to penicillin overproduction.
Journal of bacteriology 1999;181(4):1181-8.
1999: Oscar Bañuelos; Javier Casqueiro; Francisco Fierro; Maria José Hijarrubia; Santiago Gutiérrez; Juan F Martín
Characterization and lysine control of expression of the lys1 gene of Penicillium chrysogenum encoding homocitrate synthase.
Gene 1999;226(1):51-9.
1999: Santiago Gutiérrez; Francisco Fierro; Javier Casqueiro; Juan F Martín
Gene organization and plasticity of the beta-lactam genes in different filamentous fungi.
Antonie van Leeuwenhoek 1999;75(1-2):81-94.
1999: Juan F Martín; Javier Casqueiro; K Kosalková; Ana Teresa Marcos; Santiago Gutiérrez
Penicillin and cephalosporin biosynthesis: mechanism of carbon catabolite regulation of penicillin production.
Antonie van Leeuwenhoek 1999;75(1-2):21-31.
1999: Francisco Fierro; Juan F Martín
Molecular mechanisms of chromosomal rearrangement in fungi.
Critical reviews in microbiology 1999;25(1):1-17.
1998: Paloma Liras; Antonio Rodríguez-García; Juan F Martín
Evolution of the clusters of genes for beta-lactam antibiotics: a model for evolutive combinatorial assembly of new beta-lactams.
International microbiology : the official journal of the Spanish Society for Microbiology 1998;1(4):271-8.
1998: Javier Casqueiro; Santiago Gutiérrez; Oscar Bañuelos; Francisco Fierro; Javier Velasco; Juan F Martín
Characterization of the lys2 gene of Penicillium chrysogenum encoding alpha-aminoadipic acid reductase.
Molecular & general genetics : MGG 1998;259(5):549-56.
1998: FJ Pérez-Llarena; Antonio Rodríguez-García; Francisco Enguita; Juan F Martín; Paloma Liras
The pcd gene encoding piperideine-6-carboxylate dehydrogenase involved in biosynthesis of alpha-aminoadipic acid is located in the cephamycin cluster of Streptomyces clavuligerus.
Journal of bacteriology 1998;180(17):4753-6.
1998: Juan F Martín
New aspects of genes and enzymes for beta-lactam antibiotic biosynthesis.
Applied microbiology and biotechnology 1998;50(1):1-15.
1998: Rosa Elena Cardoza; Francisco J Moralejo; Santiago Gutiérrez; Javier Casqueiro; Francisco Fierro; Juan F Martín
Characterization and nitrogen-source regulation at the transcriptional level of the gdhA gene of Aspergillus awamori encoding an NADP-dependent glutamate dehydrogenase.
Current genetics 1998;34(1):50-9.
1998: Rosario Pérez-Redondo; Antonio Rodríguez-García; Juan F Martín; Paloma Liras
The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene.
Gene 1998;211(2):311-21.
1998: Agustín Pisabarro; A Correia; Juan F Martín
Pulsed-field gel electrophoresis analysis of the genome of Rhodococcus fascians: genome size and linear and circular replicon composition in virulent and avirulent strains.
Current microbiology 1998;36(5):302-8.
1998: Agustín Pisabarro; A Correia; Juan F Martín
Characterization of the rrnB operon of the plant pathogen Rhodococcus fascians and targeted integrations of exogenous genes at rrn loci.
Applied and environmental microbiology 1998;64(4):1276-82.
1997: Santiago Gutiérrez; Javier Velasco; Ana Teresa Marcos; Francisco J Fernández; Francisco Fierro; José Luis Barredo; Bruno Díez; Juan F Martín
Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum.
Applied microbiology and biotechnology 1997;48(5):606-14.
1997: Fuente Moreno; Angel Rumbero; Juan F Martín; Paloma Liras
Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes.
The Biochemical journal 1997;327 ( Pt 1)():59-64.
1997: FJ Pérez-Llarena; Juan F Martín; M Galleni; Juan José R Coque; Fuente Moreno; J M Frère; Paloma Liras
The bla gene of the cephamycin cluster of Streptomyces clavuligerus encodes a class A beta-lactamase of low enzymatic activity.
Journal of bacteriology 1997;179(19):6035-40.
1997: J Blanco; Juan José R Coque; Javier Velasco; Juan F Martín
Cloning, expression in Streptomyces lividans and biochemical characterization of a thermostable endo-beta-1,4-xylanase of Thermomonospora alba ULJB1 with cellulose-binding ability.
Applied microbiology and biotechnology 1997;48(2):208-17.
1997: Maria José Hijarrubia; Javier Casqueiro; Santiago Gutiérrez; Francisco J Fernández; Juan F Martín
Characterization of the bip gene of Aspergillus awamori encoding a protein with an HDEL retention signal homologous to the mammalian BiP involved in polypeptide secretion.
Current genetics 1997;32(2):139-46.
1997: J A Oguiza; Ana Teresa Marcos; Juan F Martín
Transcriptional analysis of the sigA and sigB genes of Brevibacterium lactofermentum.
FEMS microbiology letters 1997;153(1):111-7.
1997: Antonio Rodríguez-García; M Ludovice; Juan F Martín; Paloma Liras
Arginine boxes and the argR gene in Streptomyces clavuligerus: evidence for a clear regulation of the arginine pathway.
Molecular microbiology 1997;25(2):219-28.
1997: J Romero; Juan F Martín; Paloma Liras; Arnold L Demain; N Rius
Partial purification, characterization and nitrogen regulation of the lysine epsilon-aminotransferase of Streptomyces clavuligerus.
Journal of industrial microbiology & biotechnology 1997;18(4):241-6.
1997: FJ Pérez-Llarena; Paloma Liras; Antonio Rodríguez-García; Juan F Martín
A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds.
Journal of bacteriology 1997;179(6):2053-9.
1996: Francisco Enguita; Paloma Liras; A L Leitão; Juan F Martín
Interaction of the two proteins of the methoxylation system involved in cephamycin C biosynthesis. Immunoaffinity, protein cross-linking, and fluorescence spectroscopy studies.
The Journal of biological chemistry 1996;271(52):33225-30.
1996: C Fernández-González; José A. Gil; Luis Mateos; A Schwarzer; A Schäfer; Jörn Kalinowski; Alfred Pühler; Juan F Martín
Construction of L-lysine-overproducing strains of Brevibacterium lactofermentum by targeted disruption of the hom and thrB genes.
Applied microbiology and biotechnology 1996;46(5-6):554-8.
1996: Juan José R Coque; Fuente Moreno; Paloma Liras; Juan F Martín
Overexpression of the Nocardia lactamdurans alpha-aminoadipyl-cysteinyl-valine synthetase in Streptomyces lividans. The purified multienzyme uses cystathionine and 6-oxopiperidine 2-carboxylate as substrates for synthesis of the tripeptide.
European journal of biochemistry / FEBS 1996;242(2):264-70.
1996: J A Oguiza; Ana Teresa Marcos; M Malumbres; Juan F Martín
The galE gene encoding the UDP-galactose 4-epimerase of Brevibacterium lactofermentum is coupled transcriptionally to the dmdR gene.
Gene 1996;177(1-2):103-7.
1996: J Blanco; Juan José R Coque; Juan F Martín
Characterization of the secA gene of Streptomyces lividans encoding a protein translocase which complements and Escherichia coli mutant defective in the ATPase activity of SecA.
Gene 1996;176(1-2):61-5.
1996: M Malumbres; Juan F Martín
Molecular control mechanisms of lysine and threonine biosynthesis in amino acid-producing corynebacteria: redirecting carbon flow.
FEMS microbiology letters 1996;143(2-3):103-14.
1996: V Kumar; Fuente Moreno; A L Leitão; Paloma Liras; Juan F Martín
Effect of amplification or targeted disruption of the beta-lactamase gene of Nocardia lactamdurans on cephamycin biosynthesis.
Applied microbiology and biotechnology 1996;45(5):621-8.
1996: A Correia; Agustín Pisabarro; J M Castro; Juan F Martín
Cloning and characterization of an IS-like element present in the genome of Brevibacterium lactofermentum ATCC 13869.
Gene 1996;170(1):91-4.
1996: Francisco Enguita; Fuente Moreno; Juan F Martín; Paloma Liras
An inducible expression system of histidine-tagged proteins in Streptomyces lividans for one-step purification by Ni2+ affinity chromatography.
FEMS microbiology letters 1996;137(2-3):135-40.
1996: R F Cadenas; C Fernández-González; Juan F Martín; José A. Gil
Construction of new cloning vectors for Brevibacterium lactofermentum.
FEMS microbiology letters 1996;137(1):63-8.
1996: Juan José R Coque; Francisco Enguita; R E Cardoza; Juan F Martín; Paloma Liras
Characterization of the cefF gene of Nocardia lactamdurans encoding a 3'-methylcephem hydroxylase different from the 7-cephem hydroxylase.
Applied microbiology and biotechnology 1996;44(5):605-9.
1996: Francisco Fierro; E Montenegro; Santiago Gutiérrez; Juan F Martín
Mutants blocked in penicillin biosynthesis show a deletion of the entire penicillin gene cluster at a specific site within a conserved hexanucleotide sequence.
Applied microbiology and biotechnology 1996;44(5):597-604.
1996: J A Oguiza; Ana Teresa Marcos; M Malumbres; Juan F Martín
Multiple sigma factor genes in Brevibacterium lactofermentum: characterization of sigA and sigB.
Journal of bacteriology 1996;178(2):550-3.
1995: Antonio Rodríguez-García; Juan F Martín; Paloma Liras
The argG gene of Streptomyces clavuligerus has low homology to unstable argG from other actinomycetes: effect of amplification on clavulanic acid biosynthesis.
Gene 1995;167(1-2):9-15.
1995: Juan José R Coque; F J Pérez-Llarena; Francisco Enguita; Fuente Moreno; Juan F Martín; Paloma Liras
Characterization of the cmcH genes of Nocardia lactamdurans and Streptomyces clavuligerus encoding a functional 3'-hydroxymethylcephem O-carbamoyltransferase for cephamycin biosynthesis.
Gene 1995;162(1):21-7.
1995: Francisco Fierro; José Luis Barredo; Bruno Díez; S Gutierrez; Francisco J Fernández; Juan F Martín
The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):6200-4.
1995: Juan José R Coque; Francisco Enguita; Juan F Martín; Paloma Liras
A two-protein component 7 alpha-cephem-methoxylase encoded by two genes of the cephamycin C cluster converts cephalosporin C to 7-methoxycephalosporin C.
Journal of bacteriology 1995;177(8):2230-5.
1995: Ana Teresa Marcos; Santiago Gutiérrez; Bruno Díez; Francisco J Fernández; J A Oguiza; Juan F Martín
Three genes hrdB, hrdD and hrdT of Streptomyces griseus IMRU 3570, encoding sigma factor-like proteins, are differentially expressed under specific nutritional conditions.
Gene 1995;153(1):41-8.
1995: M Malumbres; Luis Mateos; C Guerrero; Juan F Martín
Molecular cloning of the hom-thrC-thrB cluster from Bacillus sp. ULM1: expression of the thrC gene in Escherichia coli and corynebacteria, and evolutionary relationships of the threonine genes.
Folia microbiologica 1995;40(6):595-606.
1995: J A Oguiza; X Tao; Ana Teresa Marcos; Juan F Martín; J R Murphy
Molecular cloning, DNA sequence analysis, and characterization of the Corynebacterium diphtheriae dtxR homolog from Brevibacterium lactofermentum.
Journal of bacteriology 1995;177(2):465-7.
1995: Juan F Martín; Santiago Gutiérrez
Genes for beta-lactam antibiotic biosynthesis.
Antonie van Leeuwenhoek 1995;67(2):181-200.
1994: Luis Mateos; Agustín Pisabarro; Miroslav Pátek; M Malumbres; C Guerrero; Bernhard J Eikmanns; Hermann Sahm; Juan F Martín
Transcriptional analysis and regulatory signals of the hom-thrB cluster of Brevibacterium lactofermentum.
Journal of bacteriology 1994;176(23):7362-71.
1994: H Yu; E Serpe; J Romero; Juan José R Coque; K Maeda; M Oelgeschläger; G Hintermann; Paloma Liras; Juan F Martín; Arnold L Demain
Possible involvement of the lysine epsilon-aminotransferase gene (lat) in the expression of the genes encoding ACV synthetase (pcbAB) and isopenicillin N synthase (pcbC) in Streptomyces clavuligerus.
Microbiology (Reading, England) 1994;140 ( Pt 12)():3367-77.
1994: C V Kumar; Juan José R Coque; Juan F Martín
Efficient Transformation of the Cephamycin C Producer Nocardia lactamdurans and Development of Shuttle and Promoter-Probe Cloning Vectors.
Applied and environmental microbiology 1994;60(11):4086-93.
1994: A Correia; Juan F Martín; J M Castro
Pulsed-field gel electrophoresis analysis of the genome of amino acid producing corynebacteria: chromosome sizes and diversity of restriction patterns.
Microbiology (Reading, England) 1994;140 ( Pt 10)():2841-7.
1994: Francisco J Fernández; S Gutierrez; Javier Velasco; E Montenegro; Ana Teresa Marcos; Juan F Martín
Molecular characterization of three loss-of-function mutations in the isopenicillin N-acyltransferase gene (penDE) of Penicillium chrysogenum.
Journal of bacteriology 1994;176(16):4941-8.
1994: M Malumbres; Luis Mateos; M A Lumbreras; C Guerrero; Juan F Martín
Analysis and expression of the thrC gene of Brevibacterium lactofermentum and characterization of the encoded threonine synthase.
Applied and environmental microbiology 1994;60(7):2209-19.
1994: J A Asturias; Juan F Martín; Paloma Liras
Biosynthesis and phosphate control of candicidin by Streptomyces acrimycini JI2236: effect of amplification of the pabAB gene.
Journal of industrial microbiology 1994;13(3):183-9.
1994: C Guerrero; Luis Mateos; M Malumbres; Juan F Martín
Directed mutagenesis of a regulatory palindromic sequence upstream from the Brevibacterium lactofermentum tryptophan operon.
Gene 1994;138(1-2):35-41.
1994: Juan F Martín; Santiago Gutiérrez; Francisco J Fernández; Javier Velasco; Francisco Fierro; Ana Teresa Marcos; K Kosalkova
Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins.
Antonie van Leeuwenhoek 1994;65(3):227-43.
1993: Francisco Fierro; Santiago Gutiérrez; Bruno Díez; Juan F Martín
Resolution of four large chromosomes in penicillin-producing filamentous fungi: the penicillin gene cluster is located on chromosome II (9.6 Mb) in Penicillium notatum and chromosome I (10.4 Mb) in Penicillium chrysogenum.
Molecular & general genetics : MGG 1993;241(5-6):573-8.
1993: M Malumbres; José A. Gil; Juan F Martín
Codon preference in corynebacteria.
Gene 1993;134(1):15-24.
1993: J A Oguiza; M Malumbres; G Eriani; Agustín Pisabarro; Luis Mateos; F Martin; Juan F Martín
A gene encoding arginyl-tRNA synthetase is located in the upstream region of the lysA gene in Brevibacterium lactofermentum: regulation of argS-lysA cluster expression by arginine.
Journal of bacteriology 1993;175(22):7356-62.
1993: J A DeModena; Santiago Gutiérrez; Javier Velasco; Francisco J Fernández; R A Fachini; J L Galazzo; D E Hughes; Juan F Martín
The production of cephalosporin C by Acremonium chrysogenum is improved by the intracellular expression of a bacterial hemoglobin.
Bio/technology (Nature Publishing Company) 1993;11(8):926-9.
1993: E Alvarez; B Meesschaert; E Montenegro; Santiago Gutiérrez; Bruno Díez; José Luis Barredo; Juan F Martín
The isopenicillin-N acyltransferase of Penicillium chrysogenum has isopenicillin-N amidohydrolase, 6-aminopenicillanic acid acyltransferase and penicillin amidase activities, all of which are encoded by the single penDE gene.
European journal of biochemistry / FEBS 1993;215(2):323-32.
1993: Agustín Pisabarro; M Malumbres; Luis Mateos; J A Oguiza; Juan F Martín
A cluster of three genes (dapA, orf2, and dapB) of Brevibacterium lactofermentum encodes dihydrodipicolinate synthase, dihydrodipicolinate reductase, and a third polypeptide of unknown function.
Journal of bacteriology 1993;175(9):2743-9.
1993: L M Criado; Juan F Martín; José A. Gil
The pab gene of Streptomyces griseus, encoding p-aminobenzoic acid synthase, is located between genes possibly involved in candicidin biosynthesis.
Gene 1993;126(1):135-9.
1993: Juan José R Coque; Paloma Liras; Juan F Martín
Genes for a beta-lactamase, a penicillin-binding protein and a transmembrane protein are clustered with the cephamycin biosynthetic genes in Nocardia lactamdurans.
The EMBO journal 1993;12(2):631-9.
1993: J M Cantoral; Santiago Gutiérrez; Francisco Fierro; S Gil-Espinosa; H van Liempt; Juan F Martín
Biochemical characterization and molecular genetics of nine mutants of Penicillium chrysogenum impaired in penicillin biosynthesis.
The Journal of biological chemistry 1993;268(1):737-44.
1993: Juan José R Coque; Juan F Martín; Paloma Liras
Characterization and expression in Streptomyces lividans of cefD and cefE genes from Nocardia lactamdurans: the organization of the cephamycin gene cluster differs from that in Streptomyces clavuligerus.
Molecular & general genetics : MGG 1993;236(2-3):453-8.
1992: R F Cadenas; José A. Gil; Juan F Martín
Expression of Streptomyces genes encoding extracellular enzymes in Brevibacterium lactofermentum: secretion proceeds by removal of the same leader peptide as in Streptomyces lividans.
Applied microbiology and biotechnology 1992;38(3):362-9.
1992: E Montenegro; Francisco Fierro; F J Fernandez; Santiago Gutiérrez; Juan F Martín
Resolution of chromosomes III and VI of Aspergillus nidulans by pulsed-field gel electrophoresis shows that the penicillin biosynthetic pathway genes pcbAB, pcbC, and penDE are clustered on chromosome VI (3.0 megabases).
Journal of bacteriology 1992;174(21):7063-7.
1992: Santiago Gutiérrez; Javier Velasco; F J Fernandez; Juan F Martín
The cefG gene of Cephalosporium acremonium is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase.
Journal of bacteriology 1992;174(9):3056-64.
1992: C Guerrero; Luis Mateos; M Malumbres; Juan F Martín
The bleomycin resistance gene of transposon Tn5 is an excellent marker for transformation of corynebacteria.
Applied microbiology and biotechnology 1992;36(6):759-62.
1991: Juan F Martín
Biochemistry and molecular genetics of penicillin production in Penicillium chrysogenum.
Annals of the New York Academy of Sciences 1991;646():193-201.
1991: A Daza; Juan F Martín; T Vigal; José A. Gil
Analysis of the promoter region of saf, a Streptomyces griseus gene that increases production of extracellular enzymes.
Gene 1991;108(1):63-71.
1991: T Vigal; José A. Gil; A Daza; M D García-González; P Villadas; Juan F Martín
Effects of replacement of promoters and modification of the leader peptide region of the amy gene of Streptomyces griseus on synthesis and secretion of alpha-amylase by Streptomyces lividans.
Molecular & general genetics : MGG 1991;231(1):88-96.
1991: Juan José R Coque; Paloma Liras; L Laiz; Juan F Martín
A gene encoding lysine 6-aminotransferase, which forms the beta-lactam precursor alpha-aminoadipic acid, is located in the cluster of cephamycin biosynthetic genes in Nocardia lactamdurans.
Journal of bacteriology 1991;173(19):6258-64.
1991: José Luis Barredo; Juan F Martín
Genes directly involved in the biosynthesis of beta-lactam antibiotics.
Microbiología (Madrid, Spain) 1991;7(1):1-12.
1991: Juan José R Coque; Juan F Martín; J G Calzada; Paloma Liras
The cephamycin biosynthetic genes pcbAB, encoding a large multidomain peptide synthetase, and pcbC of Nocardia lactamdurans are clustered together in an organization different from the same genes in Acremonium chrysogenum and Penicillium chrysogenum.
Molecular microbiology 1991;5(5):1125-33.
1991: Santiago Gutiérrez; Bruno Díez; E Montenegro; Juan F Martín
Characterization of the Cephalosporium acremonium pcbAB gene encoding alpha-aminoadipyl-cysteinyl-valine synthetase, a large multidomain peptide synthetase: linkage to the pcbC gene as a cluster of early cephalosporin biosynthetic genes and evidence of multiple functional domains.
Journal of bacteriology 1991;173(7):2354-65.
1991: T Vigal; José A. Gil; A Daza; M D García-González; Juan F Martín
Cloning, characterization and expression of an alpha-amylase gene from Streptomyces griseus IMRU3570.
Molecular & general genetics : MGG 1991;225(2):278-88.
1991: R F Cadenas; Juan F Martín; José A. Gil
Construction and characterization of promoter-probe vectors for Corynebacteria using the kanamycin-resistance reporter gene.
Gene 1991;98(1):117-21.
1991: M García-Domínguez; Paloma Liras; Juan F Martín
Cloning and characterization of the isopenicillin N synthase gene of Streptomyces griseus NRRL 3851 and studies of expression and complementation of the cephamycin pathway in Streptomyces clavuligerus.
Antimicrobial agents and chemotherapy 1991;35(1):44-52.
1991: Santiago Gutiérrez; Bruno Díez; E Alvarez; José Luis Barredo; Juan F Martín
Expression of the penDE gene of Penicillium chrysogenum encoding isopenicillin N acyltransferase in Cephalosporium acremonium: production of benzylpenicillin by the transformants.
Molecular & general genetics : MGG 1991;225(1):56-64.
1990: Bruno Díez; Santiago Gutiérrez; José Luis Barredo; P van Solingen; L H van der Voort; Juan F Martín
The cluster of penicillin biosynthetic genes. Identification and characterization of the pcbAB gene encoding the alpha-aminoadipyl-cysteinyl-valine synthetase and linkage to the pcbC and penDE genes.
The Journal of biological chemistry 1990;265(27):16358-65.
1990: J A Asturias; Paloma Liras; Juan F Martín
Phosphate control of pabS gene transcription during candicidin biosynthesis.
Gene 1990;93(1):79-84.
1990: Paloma Liras; J A Asturias; Juan F Martín
Phosphate control sequences involved in transcriptional regulation of antibiotic biosynthesis.
Trends in biotechnology 1990;8(7):184-9.
1990: José A. Gil; L M Criado; T Alegre; Juan F Martín
Use of a cloned gene involved in candicidin production to discover new polyene producer Streptomyces strains.
FEMS microbiology letters 1990;58(1):15-8.
1990: E Montenegro; José Luis Barredo; Santiago Gutiérrez; Bruno Díez; E Alvarez; Juan F Martín
Cloning, characterization of the acyl-CoA:6-amino penicillanic acid acyltransferase gene of Aspergillus nidulans and linkage to the isopenicillin N synthase gene.
Molecular & general genetics : MGG 1990;221(3):322-30.
1990: J M Mesas; José A. Gil; Juan F Martín
Characterization and partial purification of L-asparaginase from Corynebacterium glutamicum.
Journal of general microbiology 1990;136(3):515-9.
1989: José Luis Barredo; Bruno Díez; E Alvarez; Juan F Martín
Large amplification of a 35-kb DNA fragment carrying two penicillin biosynthetic genes in high penicillin producing strains of Penicillium chrysogenum.
Current genetics 1989;16(5-6):453-9.
1989: José Luis Barredo; P van Solingen; Bruno Díez; E Alvarez; J M Cantoral; A Kattevilder; E B Smaal; M A Groenen; A E Veenstra; Juan F Martín
Cloning and characterization of the acyl-coenzyme A: 6-aminopenicillanic-acid-acyltransferase gene of Penicillium chrysogenum.
Gene 1989;83(2):291-300.
1989: A Daza; Juan F Martín; A Dominguez; José A. Gil
Sporulation of several species of Streptomyces in submerged cultures after nutritional downshift.
Journal of general microbiology 1989;135(9):2483-91.
1989: Bruno Díez; José Luis Barredo; E Alvarez; J M Cantoral; P van Solingen; M A Groenen; A E Veenstra; Juan F Martín
Two genes involved in penicillin biosynthesis are linked in a 5.1 kb SalI fragment in the genome of Penicillium chrysogenum.
Molecular & general genetics : MGG 1989;218(3):572-6.
1989: A Rebollo; José A. Gil; Paloma Liras; J A Asturias; Juan F Martín
Cloning and characterization of a phosphate-regulated promoter involved in phosphate control of candicidin biosynthesis.
Gene 1989;79(1):47-58.
1989: José Luis Barredo; J M Cantoral; E Alvarez; Bruno Díez; Juan F Martín
Cloning, sequence analysis and transcriptional study of the isopenicillin N synthase of Penicillium chrysogenum AS-P-78.
Molecular & general genetics : MGG 1989;216(1):91-8.
1988: M Malumbres; Luis Mateos; C Guerrero; Juan F Martín
Nucleotide sequence of the threonine synthase (thrC) gene of Brevibacterium lactofermentum.
Nucleic acids research 1988;16(20):9859.
1988: J M Cantoral; José Luis Barredo; E Alvarez; Bruno Díez; Juan F Martín
Nucleotide sequence of the Penicillium chrysogenum pyrG (orotidine-5'-phosphate decarboxylase) gene.
Nucleic acids research 1988;16(16):8177.
1988: J M Castro; Paloma Liras; L Laíz; J Cortés; Juan F Martín
Purification and characterization of the isopenicillin N synthase of Streptomyces lactamdurans.
Journal of general microbiology 1988;134(1):133-41.
1987: Luis Mateos; G del Real; A Aguilar; Juan F Martín
Nucleotide sequence of the homoserine dehydrogenase (thr A) gene of Brevibacterium lactofermentum.
Nucleic acids research 1987;15(24):10598.
1987: J Cortés; Juan F Martín; J M Castro; L Láiz; Paloma Liras
Purification and characterization of a 2-oxoglutarate-linked ATP-independent deacetoxycephalosporin C synthase of Streptomyces lactamdurans.
Journal of general microbiology 1987;133(11):3165-74.
1987: E Alvarez; J M Cantoral; José Luis Barredo; Bruno Díez; Juan F Martín
Purification to homogeneity and characterization of acyl coenzyme A:6-aminopenicillanic acid acyltransferase of Penicillium chrysogenum.
Antimicrobial agents and chemotherapy 1987;31(11):1675-82.
1987: Luis Mateos; G del Real; A Aguilar; Juan F Martín
Nucleotide sequence of the homoserine kinase (thr B) gene of Brevibacterium lactofermentum.
Nucleic acids research 1987;15(9):3922.
1987: Luis Mateos; G del Real; A Aguilar; Juan F Martín
Cloning and expression in Escherichia coli of the homoserine kinase (thrB) gene from Brevibacterium lactofermentum.
Molecular & general genetics : MGG 1987;206(3):361-7.
1987: R I Santamaría; Juan F Martín; José A. Gil
Identification of a promoter sequence in the plasmid pUL340 of Brevibacterium lactofermentum and construction of new cloning vectors for corynebacteria containing two selectable markers.
Gene 1987;56(2-3):199-208.
1986: J Cortés; Paloma Liras; J M Castro; Juan F Martín
Glucose regulation of cephamycin biosynthesis in Streptomyces lactamdurans is exerted on the formation of alpha-aminoadipyl-cysteinyl-valine and deacetoxycephalosporin C synthase.
Journal of general microbiology 1986;132(7):1805-14.
1985: G del Real; A Aguilar; Juan F Martín
Cloning and expression of tryptophan genes from Brevibacterium lactofermentum in Escherichia coli.
Biochemical and biophysical research communications 1985;133(3):1013-9.
1985: José A. Gil; G Naharro; J R Villanueva; Juan F Martín
Characterization and regulation of p-aminobenzoic acid synthase from Streptomyces griseus.
Journal of general microbiology 1985;131(6):1279-87.
1980: José A. Gil; Paloma Liras; G Naharro; J R Villanueva; Juan F Martín
Regulation by aromatic amino acids of the biosynthesis of candicidin by Streptomyces griseus.
Journal of general microbiology 1980;118(1):189-95.