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Thomas Martin

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TOP 3
Kristin L Boswell; Stephen Bruinsma; Joseph M Esquibel; Hisanori Horiuchi; Declan Jonathan James; Ryutaro Shirakawa; Thomas F J Martin
Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion.
Thomas F J Martin
Role of PI(4,5)P(2) in Vesicle Exocytosis and Membrane Fusion.
Neil J Daily; Kristin L Boswell; Declan Jonathan James; Thomas F J Martin
Novel interactions of CAPS (Ca2+-dependent activator protein for secretion) with the three neuronal SNARE proteins required for vesicle fusion.

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All Publications

2012: Kristin L Boswell; Stephen Bruinsma; Joseph M Esquibel; Hisanori Horiuchi; Declan Jonathan James; Ryutaro Shirakawa; Thomas F J Martin
Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion.
The Journal of cell biology 2012;197(2):301-12.
2012: Thomas F J Martin
Role of PI(4,5)P(2) in Vesicle Exocytosis and Membrane Fusion.
Sub-cellular biochemistry 2012;59():111-30.
2010: Neil J Daily; Kristin L Boswell; Declan Jonathan James; Thomas F J Martin
Novel interactions of CAPS (Ca2+-dependent activator protein for secretion) with the three neuronal SNARE proteins required for vesicle fusion.
The Journal of biological chemistry 2010;285(46):35320-9.
2010: Declan Jonathan James; Chuenchanok Khodthong; Judith A Kowalchyk; Thomas F J Martin
Phosphatidylinositol 4,5-bisphosphate regulation of SNARE function in membrane fusion mediated by CAPS.
Advances in enzyme regulation 2010;50(1):62-70.
2009: Declan Jonathan James; Judith Kowalchyk; Neil Daily; Matt Petrie; Thomas F J Martin
CAPS drives trans-SNARE complex formation and membrane fusion through syntaxin interactions.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(41):17308-13.
2009: Mari Nojiri; Kelly M Loyet; Vadim A Klenchin; Gregory Kabachinski; Thomas F J Martin
CAPS activity in priming vesicle exocytosis requires CK2 phosphorylation.
The Journal of biological chemistry 2009;284(28):18707-14.
2008: Kara L Lynch; Roy R L Gerona; Dana M Kielar; Sascha Martens; Harvey T McMahon; Thomas F J Martin
Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion.
Molecular biology of the cell 2008;19(12):5093-103.
2008: Declan Jonathan James; Chuenchanok Khodthong; Judith A Kowalchyk; Thomas F J Martin
Phosphatidylinositol 4,5-bisphosphate regulates SNARE-dependent membrane fusion.
The Journal of cell biology 2008;182(2):355-66.
2007: Kara L Lynch; R R L Gerona; Eric C Larsen; R F Marcia; J C Mitchell; Thomas F J Martin
Synaptotagmin C2A loop 2 mediates Ca2+-dependent SNARE interactions essential for Ca2+-triggered vesicle exocytosis.
Molecular biology of the cell 2007;18(12):4957-68.
2007: Sean Speese; Matt Petrie; Kim Schuske; Michael Ailion; Kyoungsook Ann; Kouichi Iwasaki; Erik M Jorgensen; Thomas F J Martin
UNC-31 (CAPS) is required for dense-core vesicle but not synaptic vesicle exocytosis in Caenorhabditis elegans.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(23):6150-62.
2007: Kara L Lynch; Thomas F J Martin
Synaptotagmins I and IX function redundantly in regulated exocytosis but not endocytosis in PC12 cells.
Journal of cell science 2007;120(Pt 4):617-27.
2006: Yoshikatsu Aikawa; Kara L Lynch; Kristin L Boswell; Thomas F J Martin
A second SNARE role for exocytic SNAP25 in endosome fusion.
Molecular biology of the cell 2006;17(5):2113-24.
2006: Yoshikatsu Aikawa; Xiaofeng Xia; Thomas F J Martin
SNAP25, but not syntaxin 1A, recycles via an ARF6-regulated pathway in neuroendocrine cells.
Molecular biology of the cell 2006;17(2):711-22.
2005: Laurent Waselle; Roy R L Gerona; Nicolas Vitale; Thomas F J Martin; Marie-France Bader; Romano Regazzi
Role of phosphoinositide signaling in the control of insulin exocytosis.
Molecular endocrinology (Baltimore, Md.) 2005;19(12):3097-106.
2005: Trillium Blackmer; Eric C Larsen; Cheryl Bartleson; Judith A Kowalchyk; Eun-Ja Yoon; Anita M Preininger; Simon Alford; Heidi E Hamm; Thomas F J Martin
G protein betagamma directly regulates SNARE protein fusion machinery for secretory granule exocytosis.
Nature neuroscience 2005;8(4):421-5.
2005: Yoshikatsu Aikawa; Thomas F J Martin
ADP-ribosylation factor 6 regulation of phosphatidylinositol-4,5-bisphosphate synthesis, endocytosis, and exocytosis.
Methods in enzymology 2005;404():422-31.
2004: Ruslan Grishanin; Judith A Kowalchyk; Vadim A Klenchin; Kyoungsook Ann; Cynthia A Earles; Edwin R Chapman; Roy R L Gerona; Thomas F J Martin
CAPS acts at a prefusion step in dense-core vesicle exocytosis as a PIP2 binding protein.
Neuron 2004;43(4):551-62.
2003: Dina Speidel; Frederique Varoqueaux; Carsten Enk; Mari Nojiri; Ruslan Grishanin; Thomas F J Martin; Kay Hofmann; Nils Brose; Kerstin Reim
A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function.
The Journal of biological chemistry 2003;278(52):52802-9.
2003: Chih-Tien Wang; Juu-Chin Lu; Jihong Bai; Payne Y Chang; Thomas F J Martin; Edwin R Chapman; Meyer B Jackson
Different domains of synaptotagmin control the choice between kiss-and-run and full fusion.
Nature 2003;424(6951):943-7.
2003: Yoshikatsu Aikawa; Thomas F J Martin
ARF6 regulates a plasma membrane pool of phosphatidylinositol(4,5)bisphosphate required for regulated exocytosis.
The Journal of cell biology 2003;162(4):647-59.
2003: Thomas F J Martin
Tuning exocytosis for speed: fast and slow modes.
Biochimica et biophysica acta 2003;1641(2-3):157-65.
2003: Ward C Tucker; J Michael Edwardson; Jihong Bai; Hyun-Jung Kim; Thomas F J Martin; Edwin R Chapman
Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells.
The Journal of cell biology 2003;162(2):199-209.
2003: Thomas F J Martin; Ruslan Grishanin
PC12 cells as a model for studies of regulated secretion in neuronal and endocrine cells.
Methods in cell biology 2003;71():267-86.
2002: James J Wassenberg; Thomas F J Martin
Role of CAPS in dense-core vesicle exocytosis.
Annals of the New York Academy of Sciences 2002;971():201-9.
2002: Ruslan Grishanin; Vadim A Klenchin; Kelly M Loyet; Judith A Kowalchyk; Kyoungsook Ann; Thomas F J Martin
Membrane association domains in Ca2+-dependent activator protein for secretion mediate plasma membrane and dense-core vesicle binding required for Ca2+-dependent exocytosis.
The Journal of biological chemistry 2002;277(24):22025-34.
2002: Xiaodong Zhang; Mindy J Kim-Miller; Mitsunori Fukuda; Judith A Kowalchyk; Thomas F J Martin
Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis.
Neuron 2002;34(4):599-611.
2002: Thomas F J Martin
Prime movers of synaptic vesicle exocytosis.
Neuron 2002;34(1):9-12.
2002: Mitsunori Fukuda; Judith A Kowalchyk; Xiaodong Zhang; Thomas F J Martin; Katsuhiko Mikoshiba
Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells.
The Journal of biological chemistry 2002;277(7):4601-4.
2001: Chih-Tien Wang; Ruslan Grishanin; Cynthia A Earles; Payne Y Chang; Thomas F J Martin; Edwin R Chapman; Meyer B Jackson
Synaptotagmin modulation of fusion pore kinetics in regulated exocytosis of dense-core vesicles.
Science (New York, N.Y.) 2001;294(5544):1111-5.
2001: Markus R Wenk; Lorenzo Pellegrini; Vadim A Klenchin; Gilbert Di Paolo; Sunghoe Chang; Laurie Daniell; M Arioka; Thomas F J Martin; Pietro De Camilli
PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse.
Neuron 2001;32(1):79-88.
2001: Robert Renden; B Berwin; W Davis; Kyoungsook Ann; C T Chin; Robert Kreber; Barry Ganetzky; Thomas F J Martin; Kendal Broadie
Drosophila CAPS is an essential gene that regulates dense-core vesicle release and synaptic vesicle fusion.
Neuron 2001;31(3):421-37.
2001: Thomas F J Martin
PI(4,5)P(2) regulation of surface membrane traffic.
Current opinion in cell biology 2001;13(4):493-9.
2001: Trillium Blackmer; Eric C Larsen; Michiko Takahashi; Thomas F J Martin; Simon Alford; Heidi E Hamm
G protein betagamma subunit-mediated presynaptic inhibition: regulation of exocytotic fusion downstream of Ca2+ entry.
Science (New York, N.Y.) 2001;292(5515):293-7.
2000: R C Desai; B Vyas; Cynthia A Earles; J Troy Littleton; J A Kowalchyck; Thomas F J Martin; Edwin R Chapman
The C2B domain of synaptotagmin is a Ca(2+)-sensing module essential for exocytosis.
The Journal of cell biology 2000;150(5):1125-36.
2000: Vadim A Klenchin; Thomas F J Martin
Priming in exocytosis: attaining fusion-competence after vesicle docking.
Biochimie 2000;82(5):399-407.
2000: Roy R L Gerona; Eric C Larsen; Judith A Kowalchyk; Thomas F J Martin
The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes.
The Journal of biological chemistry 2000;275(9):6328-36.
1999: Abdeladim Elhamdani; Thomas F J Martin; Judith A Kowalchyk; Cristina R Artalejo
Ca(2+)-dependent activator protein for secretion is critical for the fusion of dense-core vesicles with the membrane in calf adrenal chromaffin cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(17):7375-83.
1999: Scott E Phillips; B Sha; L Topalof; Zhigang Xie; James G Alb; Vadim A Klenchin; Philip Swigart; Shamshad Cockcroft; Thomas F J Martin; M Luo; Vytas A Bankaitis
Yeast Sec14p deficient in phosphatidylinositol transfer activity is functional in vivo.
Molecular cell 1999;4(2):187-97.
1998: Vadim A Klenchin; Judith A Kowalchyk; Thomas F J Martin
Large dense-core vesicle exocytosis in PC12 cells.
Methods (San Diego, Calif.) 1998;16(2):204-8.
1998: L J Robinson; Thomas F J Martin
Docking and fusion in neurosecretion.
Current opinion in cell biology 1998;10(4):483-92.
1998: A Tandon; Serguei Bannykh; Judith A Kowalchyk; A Banerjee; Thomas F J Martin; William E Balch
Differential regulation of exocytosis by calcium and CAPS in semi-intact synaptosomes.
Neuron 1998;21(1):147-54.
1998: B Berwin; E Floor; Thomas F J Martin
CAPS (mammalian UNC-31) protein localizes to membranes involved in dense-core vesicle exocytosis.
Neuron 1998;21(1):137-45.
1998: Kelly M Loyet; Judith A Kowalchyk; A Chaudhary; J Chen; G D Prestwich; Thomas F J Martin
Specific binding of phosphatidylinositol 4,5-bisphosphate to calcium-dependent activator protein for secretion (CAPS), a potential phosphoinositide effector protein for regulated exocytosis.
The Journal of biological chemistry 1998;273(14):8337-43.
1998: C J Jeng; S A McCarroll; Thomas F J Martin; E Floor; J Adams; David E Krantz; S Butz; R Edwards; E S Schweitzer
Thy-1 is a component common to multiple populations of synaptic vesicles.
The Journal of cell biology 1998;140(3):685-98.
1998: Thomas F J Martin
Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking.
Annual review of cell and developmental biology 1998;14():231-64.
1998: Thomas F J Martin
Mechanisms of protein secretion in endocrine and exocrine cells.
Vitamins and hormones 1998;54():207-26.
1997: Thomas F J Martin; Kelly M Loyet; V A Barry; Judith A Kowalchyk
The role of PtdIns(4,5)P2 in exocytotic membrane fusion.
Biochemical Society transactions 1997;25(4):1137-41.
1997: Kyoungsook Ann; Judith A Kowalchyk; Kelly M Loyet; Thomas F J Martin
Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis.
The Journal of biological chemistry 1997;272(32):19637-40.
1997: Thomas F J Martin
Phosphoinositides as spatial regulators of membrane traffic.
Current opinion in neurobiology 1997;7(3):331-8.
1997: Thomas F J Martin; Judith A Kowalchyk
Docked secretory vesicles undergo Ca2+-activated exocytosis in a cell-free system.
The Journal of biological chemistry 1997;272(22):14447-53.
1996: A Banerjee; Judith A Kowalchyk; Bibhuti R Dasgupta; Thomas F J Martin
SNAP-25 is required for a late postdocking step in Ca2+-dependent exocytosis.
The Journal of biological chemistry 1996;271(34):20227-30.
1996: A Banerjee; V A Barry; Bibhuti R Dasgupta; Thomas F J Martin
N-Ethylmaleimide-sensitive factor acts at a prefusion ATP-dependent step in Ca2+-activated exocytosis.
The Journal of biological chemistry 1996;271(34):20223-6.
1995: J C Hay; P L Fisette; G H Jenkins; K Fukami; T Takenawa; Richard A Anderson; Thomas F J Martin
ATP-dependent inositide phosphorylation required for Ca(2+)-activated secretion.
Nature 1995;374(6518):173-7.
1995: Thomas F J Martin; J C Hay; A Banerjee; V A Barry; K Ann; H C Yom; B W Porter; Judith A Kowalchyk
Late ATP-dependent and Ca++-activated steps of dense core granule exocytosis.
Cold Spring Harbor symposia on quantitative biology 1995;60():197-204.
1994: Thomas F J Martin
The molecular machinery for fast and slow neurosecretion.
Current opinion in neurobiology 1994;4(5):626-32.
1994: Thomas F J Martin
Identification of proteins required for Ca(2+)-activated secretion.
Annals of the New York Academy of Sciences 1994;710():328-32.
1993: A Banerjee; Thomas F J Martin; Bibhuti R Dasgupta
Nerve growth factor induces sensitivity to botulinum neurotoxin type A in norepinephrine-secreting PC12 cells.
Neuroscience letters 1993;164(1-2):93-6.
1993: J C Hay; Thomas F J Martin
Phosphatidylinositol transfer protein required for ATP-dependent priming of Ca(2+)-activated secretion.
Nature 1993;366(6455):572-5.
1993: R Lomneth; J Gimenez; Thomas F J Martin; Bibhuti R Dasgupta
Calcium-dependent release of norepinephrine from permeabilized PC12 cells is inhibited by approximately 48 and approximately 112 kDa fragments of botulinum neurotoxin type E.
Neuropharmacology 1993;32(3):285-9.
1992: T Nishizaki; J H Walent; Judith A Kowalchyk; Thomas F J Martin
A key role for a 145-kDa cytosolic protein in the stimulation of Ca(2+)-dependent secretion by protein kinase C.
The Journal of biological chemistry 1992;267(33):23972-81.
1992: J C Hay; Thomas F J Martin
Resolution of regulated secretion into sequential MgATP-dependent and calcium-dependent stages mediated by distinct cytosolic proteins.
The Journal of cell biology 1992;119(1):139-51.
1992: K P Hsieh; Thomas F J Martin
Thyrotropin-releasing hormone and gonadotropin-releasing hormone receptors activate phospholipase C by coupling to the guanosine triphosphate-binding proteins Gq and G11.
Molecular endocrinology (Baltimore, Md.) 1992;6(10):1673-81.
1992: J H Walent; B W Porter; Thomas F J Martin
A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells.
Cell 1992;70(5):765-75.
1991: Thomas F J Martin; J E Lewis; Judith A Kowalchyk
Phospholipase C-beta 1 is regulated by a pertussis toxin-insensitive G-protein.
The Biochemical journal 1991;280 ( Pt 3)():753-60.
1991: R Lomneth; Thomas F J Martin; Bibhuti R Dasgupta
Botulinum neurotoxin light chain inhibits norepinephrine secretion in PC12 cells at an intracellular membranous or cytoskeletal site.
Journal of neurochemistry 1991;57(4):1413-21.
1990: Thomas F J Martin; K P Hsieh; B W Porter
The sustained second phase of hormone-stimulated diacylglycerol accumulation does not activate protein kinase C in GH3 cells.
The Journal of biological chemistry 1990;265(13):7623-31.
1989: Thomas F J Martin; Judith A Kowalchyk
Reconstitution of a solubilized membrane but not cytosolic phospholipase C with membrane-associated Gp from GH3 cells.
The Journal of biological chemistry 1989;264(35):20917-22.
1989: G Martínez de la Escalera; B W Porter; Thomas F J Martin; Richard I Weiner
Dopamine withdrawal and addition of thyrotropin-releasing hormone stimulate membrane translocation of protein kinase-C and phosphorylation of an endogenous 80K substrate in enriched lactotrophs.
Endocrinology 1989;125(3):1168-73.
1989: S M Bajjalieh; Thomas F J Martin; E Floor
Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co-purifies with brain synaptic vesicles.
The Journal of biological chemistry 1989;264(24):14354-60.
1989: Thomas F J Martin; J H Walent
A new method for cell permeabilization reveals a cytosolic protein requirement for Ca2+ -activated secretion in GH3 pituitary cells.
The Journal of biological chemistry 1989;264(17):10299-308.
1986: Thomas F J Martin; S M Bajjalieh; D O Lucas; Judith A Kowalchyk
Thyrotropin-releasing hormone stimulation of polyphosphoinositide hydrolysis in GH3 cell membranes is GTP dependent but insensitive to cholera or pertussis toxin.
The Journal of biological chemistry 1986;261(22):10141-9.
1986: Thomas F J Martin; D O Lucas; S M Bajjalieh; Judith A Kowalchyk
Thyrotropin-releasing hormone activates a Ca2+-dependent polyphosphoinositide phosphodiesterase in permeable GH3 cells. GTP gamma S potentiation by a cholera and pertussis toxin-insensitive mechanism.
The Journal of biological chemistry 1986;261(6):2918-27.
1985: D O Lucas; S M Bajjalieh; Judith A Kowalchyk; Thomas F J Martin
Direct stimulation by thyrotropin-releasing hormone (TRH) of polyphosphoinositide hydrolysis in GH3 cell membranes by a guanine nucleotide-modulated mechanism.
Biochemical and biophysical research communications 1985;132(2):721-8.
1984: Thomas F J Martin; Judith A Kowalchyk
Evidence for the role of calcium and diacylglycerol as dual second messengers in thyrotropin-releasing hormone action: involvement of Ca+2.
Endocrinology 1984;115(4):1527-36.
1984: Thomas F J Martin; Judith A Kowalchyk
Evidence for the role of calcium and diacylglycerol as dual second messengers in thyrotropin-releasing hormone action: involvement of diacylglycerol.
Endocrinology 1984;115(4):1517-26.