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Marta Martínez-Júlvez

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Publications

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Milagros Medina; Patricia Ferreira; Marta Martínez-Júlvez
Flavoproteins and flavoenzymes with biomedical and therapeutic impact.
Ana Serrano; Patricia Ferreira; Marta Martínez-Júlvez; Milagros Medina
The prokaryotic FAD synthetase family: a potential drug target.
Ana Serrano; Adrián Velázquez-Campoy; Susana Frago; Beatriz Herguedas; Marta Martínez-Júlvez; Milagros Medina
Key residues at the riboflavin kinase catalytic site of the bifunctional riboflavin kinase/FMN adenylyltransferase from Corynebacterium ammoniagenes.

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All Publications

2013: Milagros Medina; Patricia Ferreira; Marta Martínez-Júlvez
Flavoproteins and flavoenzymes with biomedical and therapeutic impact.
Current pharmaceutical design 2013;19(14):2497-8.
2013: Ana Serrano; Patricia Ferreira; Marta Martínez-Júlvez; Milagros Medina
The prokaryotic FAD synthetase family: a potential drug target.
Current pharmaceutical design 2013;19(14):2637-48.
2013: Ana Serrano; Adrián Velázquez-Campoy; Susana Frago; Beatriz Herguedas; Marta Martínez-Júlvez; Milagros Medina
Key residues at the riboflavin kinase catalytic site of the bifunctional riboflavin kinase/FMN adenylyltransferase from Corynebacterium ammoniagenes.
Cell biochemistry and biophysics 2013;65(1):57-68.
2012: Marta Martínez-Júlvez; Igor N Olekhnovich; Adriana L Rojas; Paul S Hoffman; Vladimir Espinosa Angarica; Javier Sancho
Structure of RdxA--an oxygen-insensitive nitroreductase essential for metronidazole activation in Helicobacter pylori.
The FEBS journal 2012;279(23):4306-17.
2012: C Marcuello; Marta Martínez-Júlvez; R de Miguel; Carlos Gómez-Moreno; Anabel Lostao
An efficient method for enzyme immobilization evidenced by atomic force microscopy.
Protein engineering, design & selection : PEDS 2012;25(11):715-23.
2012: Ana Sánchez-Azqueta; Matías A Musumeci; Eduardo A Ceccarelli; Marta Martínez-Júlvez; Milagros Medina
Structural backgrounds for the formation of a catalytically competent complex with NADP(H) during hydride transfer in ferredoxin-NADP(+) reductases.
Biochimica et biophysica acta 2012;1817(7):1063-71.
2012: Beatriz González; Marta Martínez-Júlvez; Rebeca Ortega; Yolanda Pérez-Pertejo; Ainhoa Revilla-Guarinos; Julia Sanz-Aparicio; Adrián Velázquez-Campoy; Francisco Garrido; María Angeles Pajares
NADP+ binding to the regulatory subunit of methionine adenosyltransferase II increases intersubunit binding affinity in the hetero-trimer.
PloS one 2012;7(11):e50329.
2011: Erandi Lira-Navarrete; Marta Martínez-Júlvez; Pedro Merino; Santosh Panjikar; Tomas Tejero; Jessika Valero-González; Raquel Villanueva; Ramon Hurtado-Guerrero
Structural insights into the mechanism of protein O-fucosylation.
PloS one 2011;6(9):e25365.
2010: M J Martínez-Pérez; R de Miguel; C Carbonera; Marta Martínez-Júlvez; Anabel Lostao; C Piquer; C Gómez-Moreno; J Bartolomé; F Luis
Size-dependent properties of magnetoferritin.
Nanotechnology 2010;21(46):465707.
2010: José Ramón Peregrina; Ana Sánchez-Azqueta; Beatriz Herguedas; Marta Martínez-Júlvez; Milagros Medina
Role of specific residues in coenzyme binding, charge-transfer complex formation, and catalysis in Anabaena ferredoxin NADP+-reductase.
Biochimica et biophysica acta 2010;1797(9):1638-46.
2010: Beatriz Herguedas; Marta Martínez-Júlvez; Susana Frago; Milagros Medina; Juan A Hermoso
Oligomeric state in the crystal structure of modular FAD synthetase provides insights into its sequential catalysis in prokaryotes.
Journal of molecular biology 2010;400(2):218-30.
2009: Beatriz Herguedas; Marta Martínez-Júlvez; Susana Frago; Milagros Medina; Juan A Hermoso
Crystallization and preliminary X-ray diffraction studies of FAD synthetase from Corynebacterium ammoniagenes.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 12):1285-8.
2009: Nunilo Cremades; Adrián Velázquez-Campoy; Marta Martínez-Júlvez; José L Neira; Inmaculada Pérez-Dorado; Juan A Hermoso; Pilar Jiménez; Angel Lanas; Paul S Hoffman; javier sancho
Discovery of specific flavodoxin inhibitors as potential therapeutic agents against Helicobacter pylori infection.
ACS chemical biology 2009;4(11):928-38.
2009: Marta Martínez-Júlvez; Milagros Medina; Adrián Velázquez-Campoy
Binding thermodynamics of ferredoxin:NADP+ reductase: two different protein substrates and one energetics.
Biophysical journal 2009;96(12):4966-75.
2009: José Ramón Peregrina; Beatriz Herguedas; Juan A Hermoso; Marta Martínez-Júlvez; Milagros Medina
Protein motifs involved in coenzyme interaction and enzymatic efficiency in anabaena ferredoxin-NADP+ reductase.
Biochemistry 2009;48(14):3109-19.
2009: Guillermina Goñi; Beatriz Herguedas; Manuel Hervás; José Ramón Peregrina; Miguel A De la Rosa; Carlos Gómez-Moreno; José A Navarro; Juan A Hermoso; Marta Martínez-Júlvez; Milagros Medina
Flavodoxin: a compromise between efficiency and versatility in the electron transfer from Photosystem I to Ferredoxin-NADP(+) reductase.
Biochimica et biophysica acta 2009;1787(3):144-54.
2008: Susana Frago; Marta Martínez-Júlvez; Ana Serrano; Milagros Medina
Structural analysis of FAD synthetase from Corynebacterium ammoniagenes.
BMC microbiology 2008;8():160.
2007: Susana Frago; Guillermina Goñi; Beatriz Herguedas; José Ramón Peregrina; Ana Serrano; Inmaculada Perez-Dorado; Rafael Molina; Carlos Gómez-Moreno; Juan A Hermoso; Marta Martínez-Júlvez; Stephen G Mayhew; Milagros Medina
Tuning of the FMN binding and oxido-reduction properties by neighboring side chains in Anabaena flavodoxin.
Archives of biochemistry and biophysics 2007;467(2):206-17.
2007: Marta Martínez-Júlvez; Nunilo Cremades; Marta Bueno; Inmaculada Pérez-Dorado; Celia Maya; Santiago Cuesta-Lopez; Diego Prada; Fernando Falo; Juan A Hermoso; javier sancho
Common conformational changes in flavodoxins induced by FMN and anion binding: the structure of Helicobacter pylori apoflavodoxin.
Proteins 2007;69(3):581-94.
2007: Jesus Tejero; José Ramón Peregrina; Marta Martínez-Júlvez; Aldo Gutiérrez; Carlos Gómez-Moreno; Nigel S Scrutton; Milagros Medina
Catalytic mechanism of hydride transfer between NADP+/H and ferredoxin-NADP+ reductase from Anabaena PCC 7119.
Archives of biochemistry and biophysics 2007;459(1):79-90.
2005: Jesus Tejero; Inmaculada Pérez-Dorado; Celia Maya; Marta Martínez-Júlvez; Julia Sanz-Aparicio; Carlos Gómez-Moreno; Juan A Hermoso; Milagros Medina
C-terminal tyrosine of ferredoxin-NADP+ reductase in hydride transfer processes with NAD(P)+/H.
Biochemistry 2005;44(41):13477-90.
2005: Tomas Mayoral; Marta Martínez-Júlvez; Inmaculada Pérez-Dorado; Julia Sanz-Aparicio; Carlos Gómez-Moreno; Milagros Medina; Juan A Hermoso
Structural analysis of interactions for complex formation between Ferredoxin-NADP+ reductase and its protein partners.
Proteins 2005;59(3):592-602.
2005: Marta Martínez-Júlvez; Jesus Tejero; José Ramón Peregrina; Isabel Nogués; Susana Frago; Carlos Gómez-Moreno; Milagros Medina
Towards a new interaction enzyme:coenzyme.
Biophysical chemistry 2005;115(2-3):219-24.
2003: Isabel Nogués; Marta Martínez-Júlvez; José A Navarro; Manuel Hervás; Lorena Armenteros; Miguel A De la Rosa; Tammy B Brodie; John K Hurley; Gordon Tollin; Carlos Gómez-Moreno; Milagros Medina
Role of hydrophobic interactions in the flavodoxin mediated electron transfer from photosystem I to ferredoxin-NADP+ reductase in Anabaena PCC 7119.
Biochemistry 2003;42(7):2036-45.
2002: John K Hurley; Renaud Morales; Marta Martínez-Júlvez; Tammy B Brodie; Milagros Medina; Carlos Gómez-Moreno; Gordon Tollin
Structure-function relationships in Anabaena ferredoxin/ferredoxin:NADP(+) reductase electron transfer: insights from site-directed mutagenesis, transient absorption spectroscopy and X-ray crystallography.
Biochimica et biophysica acta 2002;1554(1-2):5-21.
2001: Marta Martínez-Júlvez; Isabel Nogués; Merche Faro; John K Hurley; Tammy B Brodie; Tomas Mayoral; Julia Sanz-Aparicio; Juan A Hermoso; Marian T Stankovich; Milagros Medina; Gordon Tollin; Carlos Gómez-Moreno
Role of a cluster of hydrophobic residues near the FAD cofactor in Anabaena PCC 7119 ferredoxin-NADP+ reductase for optimal complex formation and electron transfer to ferredoxin.
The Journal of biological chemistry 2001;276(29):27498-510.
1999: Marta Martínez-Júlvez; Milagros Medina; Carlos Gómez-Moreno
Ferredoxin-NADP(+) reductase uses the same site for the interaction with ferredoxin and flavodoxin.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 1999;4(5):568-78.
1999: John K Hurley; James T Hazzard; Marta Martínez-Júlvez; Milagros Medina; Carlos Gómez-Moreno; Gordon Tollin
Electrostatic forces involved in orienting Anabaena ferredoxin during binding to Anabaena ferredoxin:NADP+ reductase: site-specific mutagenesis, transient kinetic measurements, and electrostatic surface potentials.
Protein science : a publication of the Protein Society 1999;8(8):1614-22.
1998: Marta Martínez-Júlvez; Juan A Hermoso; John K Hurley; Tomas Mayoral; Julia Sanz-Aparicio; Gordon Tollin; Carlos Gómez-Moreno; Milagros Medina
Role of Arg100 and Arg264 from Anabaena PCC 7119 ferredoxin-NADP+ reductase for optimal NADP+ binding and electron transfer.
Biochemistry 1998;37(51):17680-91.
1998: Carlos Gómez-Moreno; Marta Martínez-Júlvez; Milagros Medina; John K Hurley; Gordon Tollin
Protein-protein interaction in electron transfer reactions: the ferredoxin/flavodoxin/ferredoxin:NADP+ reductase system from Anabaena.
Biochimie 1998;80(10):837-46.
1998: Marta Martínez-Júlvez; Milagros Medina; John K Hurley; R Hafezi; Tammy B Brodie; Gordon Tollin; Carlos Gómez-Moreno
Lys75 of Anabaena ferredoxin-NADP+ reductase is a critical residue for binding ferredoxin and flavodoxin during electron transfer.
Biochemistry 1998;37(39):13604-13.
1998: S Schmitz; Marta Martínez-Júlvez; Carlos Gómez-Moreno; H Böhme
Interaction of positively charged amino acid residues of recombinant, cyanobacterial ferredoxin:NADP+ reductase with ferredoxin probed by site directed mutagenesis.
Biochimica et biophysica acta 1998;1363(1):85-93.
1996: Marta Martínez-Júlvez; John K Hurley; Gordon Tollin; Carlos Gómez-Moreno; María F Fillat
Overexpression in E. coli of the complete petH gene product from Anabaena: purification and properties of a 49 kDa ferredoxin-NADP+ reductase.
Biochimica et biophysica acta 1996;1297(2):200-6.
1996: Marta Martínez-Júlvez; María F Fillat; Carlos Gómez-Moreno
Kinetic characterization of Anabaena ferredoxin-NADP+ reductase mutants.
Biochemical Society transactions 1996;24(1):33S.
1996: Carlos Gómez-Moreno; Marta Martínez-Júlvez; María F Fillat; John K Hurley; Gordon Tollin
Molecular recognition in protein complexes involved in electron transfer.
Biochemical Society transactions 1996;24(1):111-6.