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Takayuki Maruyama

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Tohru Kambe; Takayuki Maruyama; Toru Maruyama; Hisao Nakai; Yoshihiko Nakai; Akio Nishiura; Hiroji Oida; Nobutaka Abe; Masaaki Toda
Synthesis and evaluation of γ-lactam analogs of PGE₂ as EP4 and EP2/EP4 agonists.
Tohru Kambe; Takayuki Maruyama; Toru Maruyama; Hisao Nakai; Yoshihiko Nakai; Akio Nishiura; Hiroji Oida; Nobutaka Abe; Hideyuki Yoshida; Masaaki Toda
Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists.
Tohru Kambe; Takayuki Maruyama; Toru Maruyama; Chiaki Minamoto; Toshihiko Nagase; Hisao Nakai; Seiji Ogawa; Kiyoto Sakata; Masaaki Toda
Synthesis and evaluation of novel modified γ-lactam prostanoids as EP4 subtype-selective agonists.

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2012: Tohru Kambe; Takayuki Maruyama; Toru Maruyama; Hisao Nakai; Yoshihiko Nakai; Akio Nishiura; Hiroji Oida; Nobutaka Abe; Masaaki Toda
Synthesis and evaluation of γ-lactam analogs of PGE₂ as EP4 and EP2/EP4 agonists.
Bioorganic & medicinal chemistry 2012;20(11):3502-22.
2012: Tohru Kambe; Takayuki Maruyama; Toru Maruyama; Hisao Nakai; Yoshihiko Nakai; Akio Nishiura; Hiroji Oida; Nobutaka Abe; Hideyuki Yoshida; Masaaki Toda
Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists.
Bioorganic & medicinal chemistry 2012;20(7):2235-51.
2012: Tohru Kambe; Takayuki Maruyama; Toru Maruyama; Chiaki Minamoto; Toshihiko Nagase; Hisao Nakai; Seiji Ogawa; Kiyoto Sakata; Masaaki Toda
Synthesis and evaluation of novel modified γ-lactam prostanoids as EP4 subtype-selective agonists.
Bioorganic & medicinal chemistry 2012;20(2):702-13.
2011: Tohru Kambe; Toru Maruyama; Takayuki Maruyama; Hisao Nakai; Masayuki Nakano; Kiyoto Sakata; Akiteru Seki; Tomoyuki Shono; Yoshiyuki Yamaura; Masaaki Toda
Discovery of orally available 8-aza-5-thiaProstaglandin E1 analogs as highly selective EP4 agonists.
Chemical & pharmaceutical bulletin 2011;59(12):1523-34.
2011: Tohru Kambe; Toru Maruyama; Takayuki Maruyama; Atsushi Naganawa; Hisao Nakai; Akiteru Seki; Masaki Asada; Masaaki Toda
Discovery of an 8-aza-5-thiaProstaglandin E1 analog as a highly selective EP4 receptor agonist.
Chemical & pharmaceutical bulletin 2011;59(12):1494-508.
2006: Atsushi Naganawa; Toshiaki Matsui; Masaki Ima; Koji Yoshida; Hiroshi Tsuruta; Shingo Yamamoto; Hiroshi Yamamoto; Hiroki Okada; Takayuki Maruyama; Hisao Nakai; Kigen Kondo; Masaaki Toda
Optimization of sulfonamide derivatives as highly selective EP1 receptor antagonists.
Bioorganic & medicinal chemistry 2006;14(23):7774-89.
2006: Atsushi Naganawa; Toshiaki Matsui; Masaki Ima; Tetsuji Saito; Masayuki Murota; Yoshiyuki Aratani; Hideomi Kijima; Hiroshi Yamamoto; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Masaaki Toda
Further optimization of sulfonamide analogs as EP1 receptor antagonists: synthesis and evaluation of bioisosteres for the carboxylic acid group.
Bioorganic & medicinal chemistry 2006;14(21):7121-37.
2006: Atsushi Naganawa; Toshiaki Matsui; Tetsuji Saito; Masaki Ima; Tadashi Tatsumi; Shingo Yamamoto; Masayuki Murota; Hiroshi Yamamoto; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Discovery of heteroaryl sulfonamides as new EP1 receptor selective antagonists.
Bioorganic & medicinal chemistry 2006;14(19):6628-39.
2006: Atsushi Naganawa; Tetsuji Saito; Yuuki Nagao; Hiromu Egashira; Maki Iwahashi; Tohru Kambe; Masatoshi Koketsu; Hiroshi Yamamoto; Michiyoshi Kobayashi; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Discovery of new chemical leads for selective EP1 receptor antagonists.
Bioorganic & medicinal chemistry 2006;14(16):5562-77.
2002: Toru Maruyama; Shin-Itsu Kuwabe; Yasufumi Kawanaka; Tai Shiraishi; Yoshiyuki Shinagawa; Kiyoto Sakata; Akiteru Seki; Yoko Kishida; Hideyuki Yoshida; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Shinsuke Hashimoto; Masanori Kawamura; Kigen Kondo; Masaaki Toda
Design and synthesis of a selective EP4-receptor agonist. Part 4: practical synthesis and biological evaluation of a novel highly selective EP4-receptor agonist.
Bioorganic & medicinal chemistry 2002;10(7):2103-10.
2002: Kousuke Tani; Atsushi Naganawa; Akiharu Ishida; Hiromu Egashira; Yoshihiko Odagaki; Toru Miyazaki; Tomoyuki Hasegawa; Yasufumi Kawanaka; Kenji Sagawa; Hiroyuki Harada; Mikio Ogawa; Takayuki Maruyama; Hisao Nakai; Shuichi Ohuchida; Kigen Kondo; Masaaki Toda
A practical synthesis and biological evaluation of 9-halogenated PGF analogues.
Bioorganic & medicinal chemistry 2002;10(6):1883-94.
2002: Toru Maruyama; Masaki Asada; Tai Shiraishi; Hideyuki Yoshida; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Design and synthesis of a selective EP4-receptor agonist. Part 3: 16-phenyl-5-thiaPGE(1) and 9-beta-halo derivatives with improved stability.
Bioorganic & medicinal chemistry 2002;10(6):1743-59.
2002: Kousuke Tani; Atsushi Naganawa; Akiharu Ishida; Hiromu Egashira; Kenji Sagawa; Hiroyuki Harada; Mikio Ogawa; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Development of a highly selective EP2-receptor agonist. Part 2: identification of 16-hydroxy-17,17-trimethylene 9beta-chloro PGF derivatives.
Bioorganic & medicinal chemistry 2002;10(4):1107-14.
2002: Kousuke Tani; Atsushi Naganawa; Akiharu Ishida; Kenji Sagawa; Hiroyuki Harada; Mikio Ogawa; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Development of a highly selective EP2-receptor agonist. Part 1: identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives.
Bioorganic & medicinal chemistry 2002;10(4):1093-106.
2002: Toru Maruyama; Masaki Asada; Tai Shiraishi; Akiharu Ishida; Hideyuki Yoshida; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Design and synthesis of a selective EP4-receptor agonist. Part 2: 3,7-dithiaPGE1 derivatives with high selectivity.
Bioorganic & medicinal chemistry 2002;10(4):989-1008.
2002: Toru Maruyama; Masaki Asada; Tai Shiraishi; Hiromu Egashira; Hideyuki Yoshida; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Design and synthesis of a selective EP4-receptor agonist. Part 1: discovery of 3,7-dithiaPGE1 derivatives and identification of their omega chains.
Bioorganic & medicinal chemistry 2002;10(4):975-88.
2001: Takayuki Maruyama; Masaki Asada; Tai Shiraishi; K Sakata; A Seki; Hideyuki Yoshida; Y Shinagawa; T Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Design and synthesis of a highly selective EP4-receptor agonist. Part 2: 5-thia and 9beta-haloPG derivatives with improved stability.
Bioorganic & medicinal chemistry letters 2001;11(15):2033-5.
2001: Takayuki Maruyama; Masaki Asada; Tai Shiraishi; Akiharu Ishida; Hiromu Egashira; Hideyuki Yoshida; T Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Design and synthesis of a highly selective EP4-receptor agonist. Part 1: 3,7-dithiaPG derivatives with high selectivity.
Bioorganic & medicinal chemistry letters 2001;11(15):2029-31.
2001: Kousuke Tani; Atsushi Naganawa; Akiharu Ishida; Hiromu Egashira; Kenji Sagawa; Hiroyuki Harada; Mikio Ogawa; Takayuki Maruyama; Shuichi Ohuchida; Hisao Nakai; Kigen Kondo; Masaaki Toda
Design and synthesis of a highly selective EP2-receptor agonist.
Bioorganic & medicinal chemistry letters 2001;11(15):2025-8.
2000: Takayuki Maruyama; Shuichi Ohuchida
[Selective agonists and antagonists for prostaglandin E2 receptor subtypes].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(6 Suppl):1001-7.
1997: Y Nakayama; K Senokuchi; K Sakaki; Masashi Kato; Takayuki Maruyama; T Miyazaki; H Ito; Hisao Nakai; M Kawamura
New serine protease inhibitors with leukotriene B4 (LTB4) receptor binding affinity.
Bioorganic & medicinal chemistry 1997;5(5):971-85.