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Wakako Maruyama

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Keiko Inaba-Hasegawa; Wakako Maruyama; Yukihiro Akao; Makoto Naoi
Rasagiline and selegiline, inhibitors of type B monoamine oxidase, induce type A monoamine oxidase in human SH-SY5Y cells.
Keiko Inaba-Hasegawa; Wakako Maruyama; Yukihiro Akao; Makoto Naoi
Type A monoamine oxidase is associated with induction of neuroprotective Bcl-2 by rasagiline, an inhibitor of type B monoamine oxidase.
Makoto Naoi; Keiko Inaba-Hasegawa; Wakako Maruyama; Yukihiro Akao
Type A monoamine oxidase regulates life and death of neurons in neurodegeneration and neuroprotection.

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2013: Keiko Inaba-Hasegawa; Wakako Maruyama; Yukihiro Akao; Makoto Naoi
Rasagiline and selegiline, inhibitors of type B monoamine oxidase, induce type A monoamine oxidase in human SH-SY5Y cells.
Journal of neural transmission (Vienna, Austria : 1996) 2013;120(3):435-44.
2012: Keiko Inaba-Hasegawa; Wakako Maruyama; Yukihiro Akao; Makoto Naoi
Type A monoamine oxidase is associated with induction of neuroprotective Bcl-2 by rasagiline, an inhibitor of type B monoamine oxidase.
Journal of neural transmission (Vienna, Austria : 1996) 2012;119(4):405-14.
2011: Makoto Naoi; Keiko Inaba-Hasegawa; Wakako Maruyama; Yukihiro Akao
Type A monoamine oxidase regulates life and death of neurons in neurodegeneration and neuroprotection.
International review of neurobiology 2011;100():85-106.
2009: Makoto Naoi; Hong Yi; Wakako Maruyama; Keiko Inaba; Masayo Shamoto-Nagai; Yukihiro Akao; Manfred Gerlach; Peter Riederer
Glutathione redox status in mitochondria and cytoplasm differentially and sequentially activates apoptosis cascade in dopamine-melanin-treated SH-SY5Y cells.
Neuroscience letters 2009;465(2):118-22.
2009: Makoto Naoi; Wakako Maruyama; Hong Yi; Keiko Inaba; Yukihiro Akao; Masayo Shamoto-Nagai
Mitochondria in neurodegenerative disorders: regulation of the redox state and death signaling leading to neuronal death and survival.
Journal of neural transmission (Vienna, Austria : 1996) 2009;116(11):1371-81.
2009: Kazushige Mizoguchi; Ryuji Ikeda; Hirotaka Shoji; Yayoi Tanaka; Xue-Long Jin; Yoshio Kase; Shuichi Takeda; Wakako Maruyama; Takeshi Tabira
Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced anxiety in rats: comparison with diazepam.
Journal of natural medicines 2009;63(1):69-74.
2008: Xuebo Liu; Naruomi Yamada; Wakako Maruyama; Toshihiko Osawa
Formation of dopamine adducts derived from brain polyunsaturated fatty acids: mechanism for Parkinson disease.
The Journal of biological chemistry 2008;283(50):34887-95.
2008: Kazushige Mizoguchi; Hirotaka Shoji; Ryuji Ikeda; Yayoi Tanaka; Wakako Maruyama; Takeshi Tabira
Suppression of glucocorticoid secretion enhances cholinergic transmission in rat hippocampus.
Brain research bulletin 2008;76(6):612-5.
2008: Makoto Naoi; Wakako Maruyama; Hong Yi; Yuriko Yamaoka; Masayo Shamoto-Nagai; Yukihiro Akao; Manfred Gerlach; Masashi Tanaka; Peter Riederer
Neuromelanin selectively induces apoptosis in dopaminergic SH-SY5Y cells by deglutathionylation in mitochondria: involvement of the protein and melanin component.
Journal of neurochemistry 2008;105(6):2489-500.
2007: Makoto Naoi; Wakako Maruyama; Hong Yi; Yukihiro Akao; Y Yamaoka; Masayo Shamoto-Nagai
Neuroprotection by propargylamines in Parkinson's disease: intracellular mechanism underlying the anti-apoptotic function and search for clinical markers.
Journal of neural transmission. Supplementum 2007;(72):121-31.
2007: Masayo Shamoto-Nagai; Wakako Maruyama; Y Hashizume; M Yoshida; Toshihiko Osawa; Peter Riederer; Makoto Naoi
In parkinsonian substantia nigra, alpha-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proteasome activity.
Journal of neural transmission (Vienna, Austria : 1996) 2007;114(12):1559-67.
2007: Kazushige Mizoguchi; Nan Sun; Xue-Long Jin; Yoshio Kase; Shuichi Takeda; Wakako Maruyama; Takeshi Tabira
Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced dysfunction of glucocorticoid negative feedback system in rat brain.
Pharmacology, biochemistry, and behavior 2007;86(1):55-61.
2006: Masayo Shamoto-Nagai; Wakako Maruyama; Hong Yi; Yukihiro Akao; F Tribl; Manfred Gerlach; Toshihiko Osawa; Peter Riederer; Makoto Naoi
Neuromelanin induces oxidative stress in mitochondria through release of iron: mechanism behind the inhibition of 26S proteasome.
Journal of neural transmission (Vienna, Austria : 1996) 2006;113(5):633-44.
2006: K Matsumoto; Yukihiro Akao; Hong Yi; Masayo Shamoto-Nagai; Wakako Maruyama; Makoto Naoi
Overexpression of amyloid precursor protein induces susceptibility to oxidative stress in human neuroblastoma SH-SY5Y cells.
Journal of neural transmission (Vienna, Austria : 1996) 2006;113(2):125-35.
2006: Wakako Maruyama; Masayo Shamoto-Nagai; Yukihiro Akao; Peter Riederer; Makoto Naoi
The effect of neuromelanin on the proteasome activity in human dopaminergic SH-SY5Y cells.
Journal of neural transmission. Supplementum 2006;(70):125-32.
2005: Makoto Naoi; Wakako Maruyama; Masayo Shamoto-Nagai; Hong Yi; Yukihiro Akao; Masashi Tanaka
Oxidative stress in mitochondria: decision to survival and death of neurons in neurodegenerative disorders.
Molecular neurobiology 2005;31(1-3):81-93.
2004: Masayo Shamoto-Nagai; Wakako Maruyama; Yukihiro Akao; Toshihiko Osawa; F Tribl; Manfred Gerlach; Fabio A Zucca; Luigi Zecca; Peter Riederer; Makoto Naoi
Neuromelanin inhibits enzymatic activity of 26S proteasome in human dopaminergic SH-SY5Y cells.
Journal of neural transmission (Vienna, Austria : 1996) 2004;111(10-11):1253-65.
2004: Masashi Tanaka; Vicente M Cabrera; Ana M González; José M Larruga; Takeshi Takeyasu; Noriyuki Fuku; Li-Jun Guo; Raita Hirose; Yasunori Fujita; Miyuki Kurata; Ken-ichi Shinoda; Kazuo Umetsu; Yoshiji Yamada; Yoshiharu Oshida; Yuzo Sato; Nobutaka Hattori; Yoshikuni Mizuno; Yasumichi Arai; Nobuyoshi Hirose; Shigeo Ohta; Osamu Ogawa; Yasushi Tanaka; Ryuzo Kawamori; Masayo Shamoto-Nagai; Wakako Maruyama; Hiroshi Shimokata; Ryota Suzuki; Hidetoshi Shimodaira
Mitochondrial genome variation in eastern Asia and the peopling of Japan.
Genome research 2004;14(10A):1832-50.
2004: Yukihiro Akao; Norio Seki; Yoshihito Nakagawa; Hong Yi; Kenji Matsumoto; Yukie Ito; Kuniyasu Ito; Masamitu Funaoka; Wakako Maruyama; Makoto Naoi; Yoshinori Nozawa
A highly bioactive lignophenol derivative from bamboo lignin exhibits a potent activity to suppress apoptosis induced by oxidative stress in human neuroblastoma SH-SY5Y cells.
Bioorganic & medicinal chemistry 2004;12(18):4791-801.
2004: Wakako Maruyama; Hong Yi; Tsutomu Takahashi; Seiichiro Shimazu; Hironori Ohde; Fumio Yoneda; Kinuko Iwasa; Makoto Naoi
Neuroprotective function of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane, [R-(-)-BPAP], against apoptosis induced by N-methyl(R)salsolinol, an endogenous dopaminergic neurotoxin, in human dopaminergic neuroblastoma SH-SY5Y cells.
Life sciences 2004;75(1):107-17.
2004: Wakako Maruyama; Atusmi Nitta; Masayo Shamoto-Nagai; Yoko Hirata; Yukihiro Akao; Moussa Yodim; Shoei Furukawa; Toshitaka Nabeshima; Makoto Naoi
N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor.
Neurochemistry international 2004;44(6):393-400.
2003: Masayo Shamoto-Nagai; Wakako Maruyama; Yoji Kato; Ken-ichi Isobe; Masashi Tanaka; Makoto Naoi; Toshihiko Osawa
An inhibitor of mitochondrial complex I, rotenone, inactivates proteasome by oxidative modification and induces aggregation of oxidized proteins in SH-SY5Y cells.
Journal of neuroscience research 2003;74(4):589-97.
2003: Wakako Maruyama; Marta Weinstock; Moussa B H Youdim; Masayo Nagai; Makoto Naoi
Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor.
Neuroscience letters 2003;341(3):233-6.
2002: Masashi Tanaka; Noriyuki Fuku; Takeshi Takeyasu; Li-Jun Guo; Raita Hirose; Miyuki Kurata; Harm-Jan W Borgeld; Yoshiji Yamada; Wakako Maruyama; Yasumichi Arai; Nobuyoshi Hirose; Yoshiharu Oshida; Yuzo Sato; Nobutaka Hattori; Yoshikuni Mizuno; So Iwata; Kunio Yagi
Golden mean to longevity: rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease.
Journal of neuroscience research 2002;70(3):347-55.
2002: Wakako Maruyama; Makoto Naoi
Cell death in Parkinson's disease.
Journal of neurology 2002;249 Suppl 2():II6-10.
2002: Wakako Maruyama; Yukihiro Akao; Maria-Cristina Carrillo; Kenichi Kitani; Moussa B H Youdium; Makoto Naoi
Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes.
Neurotoxicology and teratology 2002;24(5):675-82.
2002: Yukihiro Akao; Wakako Maruyama; Shigeomi Shimizu; Hong Yi; Yoshihito Nakagawa; Masayo Shamoto-Nagai; Moussa B H Youdim; Yoshihide Tsujimoto; Makoto Naoi
Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan.
Journal of neurochemistry 2002;82(4):913-23.
2002: Yukihiro Akao; Wakako Maruyama; Hong Yi; Masayo Shamoto-Nagai; Moussa B H Youdim; Makoto Naoi
An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic bcl-2 in human dopaminergic SH-SY5Y cells.
Neuroscience letters 2002;326(2):105-8.
2002: Wakako Maruyama; T Takahashi; Moussa B H Youdim; Makoto Naoi
The anti-Parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human dopaminergic neuroblastoma SH-SY5Y cells.
Journal of neural transmission (Vienna, Austria : 1996) 2002;109(4):467-81.
2002: Wakako Maruyama; Tomoko Oya-Ito; Masayo Shamoto-Nagai; Toshihiko Osawa; Makoto Naoi
Glyceraldehyde-3-phospate dehydrogenase is translocated into nuclei through Golgi apparatus during apoptosis induced by 6-hydroxydopamine in human dopaminergic SH-SY5Y cells.
Neuroscience letters 2002;321(1-2):29-32.
2002: Masashi Tanaka; Harm-Jan W Borgeld; Jin Zhang; Shin-ichi Muramatsu; Jian-Sheng Gong; Makoto Yoneda; Wakako Maruyama; Makoto Naoi; Tohru Ibi; Ko Sahashi; Masayo Shamoto; Noriyuki Fuku; Miyuki Kurata; Yoshiji Yamada; Kumi Nishizawa; Yukihiro Akao; Nobuko Ohishi; Shigeaki Miyabayashi; Hiraku Umemoto; Tatsuo Muramatsu; Koichi Furukawa; Akihiko Kikuchi; Imaharu Nakano; Keiya Ozawa; Kunio Yagi
Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria.
Journal of biomedical science 2002;9(6 Pt 1):534-41.
2002: T Yamamoto; Wakako Maruyama; Y Kato; Hong Yi; Masayo Shamoto-Nagai; Masashi Tanaka; Yuzo Sato; Makoto Naoi
Selective nitration of mitochondrial complex I by peroxynitrite: involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells.
Journal of neural transmission (Vienna, Austria : 1996) 2002;109(1):1-13.
2001: Wakako Maruyama; Y Akao; Moussa B H Youdim; B A Davis; Makoto Naoi
Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol.
Journal of neurochemistry 2001;78(4):727-35.
2001: Wakako Maruyama; Moussa B H Youdim; Makoto Naoi
Antiapoptotic properties of rasagiline, N-propargylamine-1(R)-aminoindan, and its optical (S)-isomer, TV1022.
Annals of the New York Academy of Sciences 2001;939():320-9.
2001: Kenichi Kitani; Chiyoko Minami; Takako Yamamoto; Wakako Maruyama; Setsuko Kanai; Gwen O Ivy; Maria-Cristina Carrillo
Do antioxidant strategies work against aging and age-associated disorders? Propargylamines: a possible antioxidant strategy.
Annals of the New York Academy of Sciences 2001;928():248-60.
2001: Kentaro Oh-Hashi; Wakako Maruyama; K i Isobe
Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells.
Free radical biology & medicine 2001;30(2):213-21.
2001: Wakako Maruyama; Alan A Boulton; BA Davis; P Dostert; Makoto Naoi
Enantio-specific induction of apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopaminergic SH-SY5Y cells: suppression of apoptosis by N-(2-heptyl)-N-methylpropargylamine.
Journal of neural transmission (Vienna, Austria : 1996) 2001;108(1):11-24.
2000: Wakako Maruyama; Makoto Naoi
[Studies on endogenous toxins as pathogenic factors in idiopathic parkinson's disease].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2000;116(6):333-42.
2000: Wakako Maruyama; K Sango; K Iwasa; Chiyoko Minami; P Dostert; M Kawai; Masataka Moriyasu; Makoto Naoi
Dopaminergic neurotoxins, 6,7-dihydroxy-1-(3', 4'-dihydroxybenzyl)-isoquinolines, cause different types of cell death in SH-SY5Y cells: apoptosis was induced by oxidized papaverolines and necrosis by reduced tetrahydropapaverolines.
Neuroscience letters 2000;291(2):89-92.
2000: Wakako Maruyama; Takako Yamamoto; Kenichi Kitani; Maria-Cristina Carrillo; Moussa B H Youdim; Makoto Naoi
Mechanism underlying anti-apoptotic activity of a (-)deprenyl-related propargylamine, rasagiline.
Mechanisms of ageing and development 2000;116(2-3):181-91.
2000: Maria-Cristina Carrillo; Chiyoko Minami; Kenichi Kitani; Wakako Maruyama; K Ohashi; Takako Yamamoto; Makoto Naoi; Setsuko Kanai; Moussa B H Youdim
Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat.
Life sciences 2000;67(5):577-85.
2000: K Sango; Wakako Maruyama; K Matsubara; P Dostert; Chiyoko Minami; M Kawai; Makoto Naoi
Enantio-selective occurrence of (S)-tetrahydropapaveroline in human brain.
Neuroscience letters 2000;283(3):224-6.
2000: Wakako Maruyama; Yukihiro Akao; Moussa B H Youdim; Makoto Naoi
Neurotoxins induce apoptosis in dopamine neurons: protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022.
Journal of neural transmission. Supplementum 2000;(60):171-86.
2000: Kenichi Kitani; Chiyoko Minami; Wakako Maruyama; Setsuko Kanai; Gwen O Ivy; Maria-Cristina Carrillo
Common properties for propargylamines of enhancing superoxide dismutase and catalase activities in the dopaminergic system in the rat: implications for the life prolonging effect of (-)deprenyl.
Journal of neural transmission. Supplementum 2000;(60):139-56.
2000: Wakako Maruyama; M Strolin-Benedetti; Makoto Naoi
N-methyl(R)salsolinol and a neutral N-methyltransferase as pathogenic factors in Parkinson's disease.
Neurobiology (Budapest, Hungary) 2000;8(1):55-68.
1999: Wakako Maruyama; Makoto Naoi
Neuroprotection by (-)-deprenyl and related compounds.
Mechanisms of ageing and development 1999;111(2-3):189-200.
1999: Kentaro Oh-Hashi; Wakako Maruyama; H Yi; Tsutomu Takahashi; Makoto Naoi; K i Isobe
Mitogen-activated protein kinase pathway mediates peroxynitrite-induced apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells.
Biochemical and biophysical research communications 1999;263(2):504-9.
1999: Yukihiro Akao; Yoshihito Nakagawa; Wakako Maruyama; T Takahashi; Makoto Naoi
Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, is mediated by activation of caspase 3.
Neuroscience letters 1999;267(3):153-6.
1999: Wakako Maruyama; T Abe; H Tohgi; Makoto Naoi
An endogenous MPTP-like dopaminergic neurotoxin, N-methyl(R)salsolinol, in the cerebrospinal fluid decreases with progression of Parkinson's disease.
Neuroscience letters 1999;262(1):13-6.
1999: Makoto Naoi; Wakako Maruyama
N-methyl(R)salsolinol, a dopamine neurotoxin, in Parkinson's disease.
Advances in neurology 1999;80():259-64.
1998: Wakako Maruyama; Tsutomu Takahashi; Makoto Naoi
(-)-Deprenyl protects human dopaminergic neuroblastoma SH-SY5Y cells from apoptosis induced by peroxynitrite and nitric oxide.
Journal of neurochemistry 1998;70(6):2510-5.
1998: Makoto Naoi; Wakako Maruyama; N Nakao; Tohru Ibi; Ko Sahashi; M S Benedetti
(R)salsolinol N-methyltransferase activity increases in parkinsonian lymphocytes.
Annals of neurology 1998;43(2):212-6.
1998: N Morikawa; Makoto Naoi; Wakako Maruyama; S Ohta; Y Kotake; H Kawai; T Niwa; P Dostert; Yoshikuni Mizuno
Effects of various tetrahydroisoquinoline derivatives on mitochondrial respiration and the electron transfer complexes.
Journal of neural transmission (Vienna, Austria : 1996) 1998;105(6-7):677-88.
1998: Chiyoko Minami; Y Deng; Wakako Maruyama; Tsutomu Takahashi; M Kawai; D Nakahara; Makoto Naoi
Generation of reactive oxygen species accounts for cytotoxicity of an endogenous dopaminergic neurotoxin, (R)-N-methylsalsolinol, to differentiated dopaminergic SH-SY5Y cells.
Journal of neural transmission (Vienna, Austria : 1996) 1998;105(4-5):397-405.
1998: Makoto Naoi; Wakako Maruyama; T Kasamatsu; P Dostert
Oxidation of N-methyl(R)salsolinol: involvement to neurotoxicity and neuroprotection by endogenous catechol isoquinolines.
Journal of neural transmission. Supplementum 1998;52():125-38.
1997: Makoto Naoi; Wakako Maruyama; K Matsubara; Y Hashizume
A neutral N-methyltransferase activity in the striatum determines the level of an endogenous MPP+-like neurotoxin, 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion, in the substantia nigra of human brains.
Neuroscience letters 1997;235(1-2):81-4.
1997: Wakako Maruyama; M S Benedetti; T Takahashi; Makoto Naoi
A neurotoxin N-methyl(R)salsolinol induces apoptotic cell death in differentiated human dopaminergic neuroblastoma SH-SY5Y cells.
Neuroscience letters 1997;232(3):147-50.
1997: Wakako Maruyama; Makoto Naoi; T Kasamatsu; Y Hashizume; Tsutomu Takahashi; K Kohda; P Dostert
An endogenous dopaminergic neurotoxin, N-methyl-(R)-salsolinol, induces DNA damage in human dopaminergic neuroblastoma SH-SY5Y cells.
Journal of neurochemistry 1997;69(1):322-9.
1997: Y Deng; Wakako Maruyama; M Kawai; P Dostert; H Yamamura; Tsutomu Takahashi; Makoto Naoi
Assay for the (R)- and (S)-enantiomers of salsolinols in biological samples and foods with ion-pair high-performance liquid chromatography using beta-cyclodextrin as a chiral mobile phase additive.
Journal of chromatography. B, Biomedical sciences and applications 1997;689(2):313-20.
1997: Wakako Maruyama; G Sobue; K Matsubara; Y Hashizume; P Dostert; Makoto Naoi
A dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl(R)salsolinol, and its oxidation product, 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion, accumulate in the nigro-striatal system of the human brain.
Neuroscience letters 1997;223(1):61-4.
1997: Makoto Naoi; Wakako Maruyama; P Dostert; Y Hashizume
N-methyl-(R)salsolinol as a dopaminergic neurotoxin: from an animal model to an early marker of Parkinson's disease.
Journal of neural transmission. Supplementum 1997;50():89-105.
1997: Tsutomu Takahashi; Wakako Maruyama; Y Deng; P Dostert; D Nakahara; T Niwa; S Ohta; Makoto Naoi
Cytotoxicity of endogenous isoquinolines to human dopaminergic neuroblastoma SH-SY5Y cells.
Journal of neural transmission (Vienna, Austria : 1996) 1997;104(1):59-66.
1996: K Matsubara; Yuta Kobayashi; Y Tanabe; Wakako Maruyama; Y Ishinaga; T Idzu; K Kimura; Makoto Naoi
Modulation of tryptophan hydroxylase activity in vitro by ethanol depends on biopterin cofactor concentration.
Alcohol (Fayetteville, N.Y.) 1996;13(5):455-9.
1996: Y Deng; Wakako Maruyama; H Yamamura; M Kawai; P Dostert; Makoto Naoi
Mechanism of enantioseparation of salsolinols, endogenous neurotoxins in human brain, with ion-pair chromatography using beta-cyclodextrin as a mobile phase additive.
Analytical chemistry 1996;68(17):2826-31.
1996: Makoto Naoi; Wakako Maruyama; P Dostert; Kohfuku Kohda; Toyo Kaiya
A novel enzyme enantio-selectively synthesizes (R)salsolinol, a precursor of a dopaminergic neurotoxin, N-methyl(R)salsolinol.
Neuroscience letters 1996;212(3):183-6.
1996: Wakako Maruyama; Makoto Naoi; H Narabayashi
The metabolism of L-DOPA and L-threo-3,4-dihydroxyphenylserine and their effects on monoamines in the human brain: analysis of the intraventricular fluid from parkinsonian patients.
Journal of the neurological sciences 1996;139(1):141-8.
1996: Wakako Maruyama; Tomio Abe; H Tohgi; P Dostert; Makoto Naoi
A dopaminergic neurotoxin, (R)-N-methylsalsolinol, increases in Parkinsonian cerebrospinal fluid.
Annals of neurology 1996;40(1):119-22.
1996: Makoto Naoi; Wakako Maruyama; P Dostert; Y Hashizume; D Nakahara; T Takahashi; M Ota
Dopamine-derived endogenous 1(R),2(N)-dimethyl-6,7-dihydroxy- 1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioral studies.
Brain research 1996;709(2):285-95.
1996: Wakako Maruyama; Y Hashizume; K Matsubara; Makoto Naoi
Identification of 3-nitro-L-tyrosine, a product of nitric oxide and superoxide, as an indicator of oxidative stress in the human brain.
Journal of chromatography. B, Biomedical applications 1996;676(1):153-8.
1996: Wakako Maruyama; H Narabayashi; P Dostert; Makoto Naoi
Stereospecific occurrence of a parkinsonism-inducing catechol isoquinoline, N-methyl(R)salsolinol, in the human intraventricular fluid.
Journal of neural transmission (Vienna, Austria : 1996) 1996;103(8-9):1069-76.
1995: K Matsubara; T Idzu; Yuta Kobayashi; D Nakahara; Wakako Maruyama; S Kobayashi; K Kimura; Makoto Naoi
N-methyl-4-phenylpyridinium and an endogenously formed analog, N-methylated beta-carbolinium, inhibit striatal tyrosine hydroxylation in freely moving rats.
Neuroscience letters 1995;199(3):199-202.
1995: Y Deng; Wakako Maruyama; P Dostert; Tsutomu Takahashi; M Kawai; Makoto Naoi
Determination of the (R)- and (S)-enantiomers of salsolinol and N-methylsalsolinol by use of a chiral high-performance liquid chromatographic column.
Journal of chromatography. B, Biomedical applications 1995;670(1):47-54.
1995: Wakako Maruyama; P Dostert; K Matsubara; Makoto Naoi
N-methyl(R)salsolinol produces hydroxyl radicals: involvement to neurotoxicity.
Free radical biology & medicine 1995;19(1):67-75.
1995: Wakako Maruyama; P Dostert; Makoto Naoi
Dopamine-derived 1-methyl-6,7-dihydroxyisoquinolines as hydroxyl radical promoters and scavengers in the rat brain: in vivo and in vitro studies.
Journal of neurochemistry 1995;64(6):2635-43.
1995: Makoto Naoi; Wakako Maruyama; P Dostert
Dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines; oxidation and neurotoxicity.
Progress in brain research 1995;106():227-39.
1995: Makoto Naoi; Wakako Maruyama; J H Zhang; T Takahashi; Y Deng; P Dostert
Enzymatic oxidation of the dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, into 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion.
Life sciences 1995;57(11):1061-6.
1994: Makoto Naoi; Wakako Maruyama; S Sasuga; Y Deng; P Dostert; S Ohta; T Takahashi
Inhibition of type A monoamine oxidase by 2(N)-methyl-6,7-dihydroxyisoquinolinium ions.
Neurochemistry international 1994;25(5):475-81.
1994: Wakako Maruyama; M Naoi; H Narabayashi
[Study on the metabolism of droxidopa in humans].
Rinshō shinkeigaku = Clinical neurology 1994;34(10):991-5.
1994: Wakako Maruyama; Makoto Naoi; H Narabayashi
[The effect of droxidopa on the monoamine metabolsim in the human brain].
Rinshō shinkeigaku = Clinical neurology 1994;34(10):985-90.
1994: K Matsubara; M Ota; T Takahashi; Wakako Maruyama; Makoto Naoi
Structural studies of condensation products of biogenic amines as inhibitors of tryptophan hydroxylase.
Brain research 1994;655(1-2):121-7.
1994: Makoto Naoi; Wakako Maruyama; T Takahashi; M Ota; H Parvez
Inhibition of tryptophan hydroxylase by dopamine and the precursor amino acids.
Biochemical pharmacology 1994;48(1):207-11.
1994: D Nakahara; Wakako Maruyama; H Hashiguti; Makoto Naoi
Characterization of the in vivo action of (R)-salsolinol, an endogenous metabolite of alcohol, on serotonin and dopamine metabolism: a microdialysis study.
Brain research 1994;644(2):226-32.
1994: Makoto Naoi; Wakako Maruyama; P Dostert
Binding of 1,2(N)-dimethyl-6,7-dihydroxy-isoquinolinium ion to melanin: effects of ferrous and ferric ion on the binding.
Neuroscience letters 1994;171(1-2):9-12.
1994: M Kajita; Toshimitsu Niwa; Wakako Maruyama; D Nakahara; N Takeda; H Yoshizumi; A Tatematsu; Kazuyoshi Watanabe; Makoto Naoi; Toshiharu Nagatsu
Endogenous synthesis of N-methylnorsalsolinol in rat brain during in vivo microdialysis with epinine.
Journal of chromatography. B, Biomedical applications 1994;654(2):263-9.
1994: Wakako Maruyama; D Nakahara; Makoto Naoi
A new metabolic pathway of L-threo-3,4-dihydroxyphenylserine, a precursor amino acid of norepinephrine, in the brain. Studies by in vivo microdialysis.
Journal of neural transmission. Parkinson's disease and dementia section 1994;7(1):21-33.
1994: Wakako Maruyama; A Ota; A Takahashi; Toshiharu Nagatsu; Makoto Naoi
Food-derived heterocyclic amines, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and related amines, as inhibitors of monoamine metabolism.
Journal of neural transmission. Supplementum 1994;41():327-33.
1994: Makoto Naoi; Wakako Maruyama; T Niwa; Toshiharu Nagatsu
Novel toxins and Parkinson's disease: N-methylation and oxidation as metabolic bioactivation of neurotoxin.
Journal of neural transmission. Supplementum 1994;41():197-205.
1994: Wakako Maruyama; Makoto Naoi
Inhibition of tyrosine hydroxylase by a dopamine neurotoxin, 1-methyl-4-phenylpyridinium ion: depletion of allostery to the biopterin cofactor.
Life sciences 1994;55(3):207-12.
1994: T Takahashi; Y Deng; Wakako Maruyama; P Dostert; M Kawai; Makoto Naoi
Uptake of a neurotoxin-candidate, (R)-1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline into human dopaminergic neuroblastoma SH-SY5Y cells by dopamine transport system.
Journal of neural transmission. General section 1994;98(2):107-18.
1993: Wakako Maruyama; D Nakahara; P Dostert; H Hashiguchi; S Ohta; M Hirobe; A Takahashi; Toshiharu Nagatsu; Makoto Naoi
Selective release of serotonin by endogenous alkaloids, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines, (R)- and (S)salsolinol, in the rat striatum; in vivo microdialysis study.
Neuroscience letters 1993;149(2):115-8.
1993: Makoto Naoi; Wakako Maruyama
Type B monoamine oxidase and neurotoxins.
European neurology 1993;33 Suppl 1():31-7.
1993: M Minami; Wakako Maruyama; P Dostert; Toshiharu Nagatsu; Makoto Naoi
Inhibition of type A and B monoamine oxidase by 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines and their N-methylated derivatives.
Journal of neural transmission. General section 1993;92(2-3):125-35.
1993: Wakako Maruyama; T Takahashi; M Minami; A Takahashi; P Dostert; Toshiharu Nagatsu; Makoto Naoi
Cytotoxicity of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines.
Advances in neurology 1993;60():224-30.
1993: H Hashiguti; D Nakahara; Wakako Maruyama; Makoto Naoi; T Ikeda
Simultaneous determination of in vivo hydroxylation of tyrosine and tryptophan in rat striatum by microdialysis-HPLC: relationship between dopamine and serotonin biosynthesis.
Journal of neural transmission. General section 1993;93(3):213-23.
1993: Wakako Maruyama; D Nakahara; P Dostert; A Takahashi; Makoto Naoi
Naturally-occurring isoquinolines perturb monamine metabolism in the brain: studied by in vivo microdialysis.
Journal of neural transmission. General section 1993;94(2):91-102.
1992: Wakako Maruyama; D Nakahara; M Ota; T Takahashi; A Takahashi; Toshiharu Nagatsu; Makoto Naoi
N-methylation of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, (R)-salsolinol, in rat brains: in vivo microdialysis study.
Journal of neurochemistry 1992;59(2):395-400.
1992: Toshimitsu Niwa; Wakako Maruyama; D Nakahara; N Takeda; H Yoshizumi; A Tatematsu; A Takahashi; P Dostert; Makoto Naoi; Toshiharu Nagatsu
Endogenous synthesis of N-methylsalsolinol, an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, in rat brain during in vivo microdialysis with salsolinol, as demonstrated by gas chromatography-mass spectrometry.
Journal of chromatography 1992;578(1):109-15.
1992: M Minami; T Takahashi; Wakako Maruyama; A Takahashi; P Dostert; Toshiharu Nagatsu; Makoto Naoi
Inhibition of tyrosine hydroxylase by R and S enantiomers of salsolinol, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline.
Journal of neurochemistry 1992;58(6):2097-101.
1992: Wakako Maruyama; Makoto Naoi; A Takahashi; H Watanabe; Y Konagaya; K Mokuno; S Hasegawa; D Nakahara
The mechanism of perturbation in monoamine metabolism by L-dopa therapy: in vivo and in vitro studies.
Journal of neural transmission. General section 1992;90(3):183-97.
1992: M Minami; T Takahashi; Wakako Maruyama; A Takahashi; Toshiharu Nagatsu; Makoto Naoi
Allosteric effect of tetrahydrobiopterin cofactors on tyrosine hydroxylase activity.
Life sciences 1992;50(1):15-20.
1991: Wakako Maruyama; M Minami; A Ota; T Takahashi; A Takahashi; Toshiharu Nagatsu; Makoto Naoi
Reduction of enzymatic activity of tyrosine hydroxylase by a heterocyclic amine, 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole (Trp-P-1), was due to reduced affinity to a cofactor biopterin.
Neuroscience letters 1991;125(1):85-8.