Joan Massagué

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Physiology

Sign-in to see full Profile

Sign-in to see all Coauthors

Publications

TOP 3
Gao Sheng; Alarcón Claudio; Sapkota Gopal; Rahman Sadia; Chen Pan-Yu; Goerner Nina; Macias Maria J; Erdjument-Bromage Hediye; Tempst Paul; Massagué Joan
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling.
Alarcón Claudio; Zaromytidou Alexia-Ileana; Xi Qiaoran; Gao Sheng; Yu Jianzhong; Fujisawa Sho; Barlas Afsar; Miller Alexandria N; Manova-Todorova Katia; Macias Maria J; Sapkota Gopal; Pan Duojia; Massagué Joan
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways.
Lu Xin; Wang Qiongqing; Hu Guohong; Van Poznak Catherine; Fleisher Martin; Reiss Michael; Massagué Joan; Kang Yibin
ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Joan Massagué (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Gao Sheng; Alarcón Claudio; Sapkota Gopal; Rahman Sadia; Chen Pan-Yu; Goerner Nina; Macias Maria J; Erdjument-Bromage Hediye; Tempst Paul; Massagué Joan
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling.
Molecular cell 2009;36(3):457-68.
2009: Alarcón Claudio; Zaromytidou Alexia-Ileana; Xi Qiaoran; Gao Sheng; Yu Jianzhong; Fujisawa Sho; Barlas Afsar; Miller Alexandria N; Manova-Todorova Katia; Macias Maria J; Sapkota Gopal; Pan Duojia; Massagué Joan
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways.
Cell 2009;139(4):757-69.
2009: Lu Xin; Wang Qiongqing; Hu Guohong; Van Poznak Catherine; Fleisher Martin; Reiss Michael; Massagué Joan; Kang Yibin
ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis.
Genes & development 2009;23(16):1882-94.
2009: Nguyen Don X; Chiang Anne C; Zhang Xiang H-F; Kim Juliet Y; Kris Mark G; Ladanyi Marc; Gerald William L; Massagué Joan
WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis.
Cell 2009;138(1):51-62.
2009: Zhang Xiang H-F; Wang Qiongqing; Gerald William; Hudis Clifford A; Norton Larry; Smid Marcel; Foekens John A; Massagué Joan
Latent bone metastasis in breast cancer tied to Src-dependent survival signals.
Cancer cell 2009;16(1):67-78.
2009: Bos Paula D; Zhang Xiang H-F; Nadal Cristina; Shu Weiping; Gomis Roger R; Nguyen Don X; Minn Andy J; van de Vijver Marc J; Gerald William L; Foekens John A; Massagué Joan
Genes that mediate breast cancer metastasis to the brain.
Nature 2009;459(7249):1005-9.
2009: Nguyen Don X; Bos Paula D; Massagué Joan
Metastasis: from dissemination to organ-specific colonization.
Nature reviews. Cancer 2009;9(4):274-84.
2009: Padua David; Massagué Joan
Roles of TGFbeta in metastasis.
Cell research 2009;19(1):89-102.
2008: Chiang Anne C; Massagué Joan
Molecular basis of metastasis.
The New England journal of medicine 2008;359(26):2814-23.
2008: Massagué Joan
TGFbeta in Cancer.
Cell 2008;134(2):215-30.
2008: Padua David; Zhang Xiang H-F; Wang Qiongqing; Nadal Cristina; Gerald William L; Gomis Roger R; Massagué Joan
TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4.
Cell 2008;133(1):66-77.
2008: Hall Alan; Massagué Joan
Cell regulation.
Current opinion in cell biology 2008;20(2):117-8.
2008: Massagué Joan
A very private TGF-beta receptor embrace.
Molecular cell 2008;29(2):149-50.
2008: Tavazoie Sohail F; Alarcón Claudio; Oskarsson Thordur; Padua David; Wang Qiongqing; Bos Paula D; Gerald William L; Massagué Joan
Endogenous human microRNAs that suppress breast cancer metastasis.
Nature 2008;451(7175):147-52.
2008: Xi Qiaoran; He Wei; Zhang Xiang H-F; Le Hong-Van; Massagué Joan
Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program.
The Journal of biological chemistry 2008;283(2):1146-55.
2007: Gupta Gaorav P; Perk Jonathan; Acharyya Swarnali; de Candia Paola; Mittal Vivek; Todorova-Manova Katia; Gerald William L; Brogi Edi; Benezra Robert; Massagué Joan
ID genes mediate tumor reinitiation during breast cancer lung metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(49):19506-11.
2007: Nguyen Don X; Massagué Joan
Genetic determinants of cancer metastasis.
Nature reviews. Genetics 2007;8(5):341-52.
2007: Gupta Gaorav P; Nguyen Don X; Chiang Anne C; Bos Paula D; Kim Juliet Y; Nadal Cristina; Gomis Roger R; Manova-Todorova Katia; Massagué Joan
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis.
Nature 2007;446(7137):765-70.
2007: Minn Andy J; Gupta Gaorav P; Padua David; Bos Paula; Nguyen Don X; Nuyten Dimitry; Kreike Bas; Zhang Yi; Wang Yixin; Ishwaran Hemant; Foekens John A; van de Vijver Marc; Massagué Joan
Lung metastasis genes couple breast tumor size and metastatic spread.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(16):6740-5.
2007: Sapkota Gopal; Alarcón Claudio; Spagnoli Francesca M; Brivanlou Ali H; Massagué Joan
Balancing BMP signaling through integrated inputs into the Smad1 linker.
Molecular cell 2007;25(3):441-54.
2007: Massagué Joan
Sorting out breast-cancer gene signatures.
The New England journal of medicine 2007;356(3):294-7.
2007: Li Feng; Tiede Benjamin; Massagué Joan; Kang Yibin
Beyond tumorigenesis: cancer stem cells in metastasis.
Cell research 2007;17(1):3-14.
2006: Sapkota Gopal; Knockaert Marie; Alarcón Claudio; Montalvo Ermelinda; Brivanlou Ali H; Massagué Joan
Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways.
The Journal of biological chemistry 2006;281(52):40412-9.
2006: Gupta Gaorav P; Massagué Joan
Cancer metastasis: building a framework.
Cell 2006;127(4):679-95.
2006: Gomis Roger R; Alarcón Claudio; Nadal Cristina; Van Poznak Catherine; Massagué Joan
C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells.
Cancer cell 2006;10(3):203-14.
2006: Gomis Roger R; Alarcón Claudio; He Wei; Wang Qiongqing; Seoane Joan; Lash Alex; Massagué Joan
A FoxO-Smad synexpression group in human keratinocytes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(34):12747-52.
2006: Norton Larry; Massagué Joan
Is cancer a disease of self-seeding?
Nature medicine 2006;12(8):875-8.
2006: Knockaert Marie; Sapkota Gopal; Alarcón Claudio; Massagué Joan; Brivanlou Ali H
Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(32):11940-5.
2006: He Wei; Dorn David C; Erdjument-Bromage Hediye; Tempst Paul; Moore Malcolm A S; Massagué Joan
Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.
Cell 2006;125(5):929-41.
2006: Massagué Joan; Gomis Roger R
The logic of TGFbeta signaling.
FEBS letters 2006;580(12):2811-20.
2005: Massagué Joan; Seoane Joan; Wotton David
Smad transcription factors.
Genes & development 2005;19(23):2783-810.
2005: Thomas Dori A; Massagué Joan
TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance.
Cancer cell 2005;8(5):369-80.
2005: Kang Yibin; He Wei; Tulley Shaun; Gupta Gaorav P; Serganova Inna; Chen Chang-Rung; Manova-Todorova Katia; Blasberg Ronald; Gerald William L; Massagué Joan
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(39):13909-14.
2005: Le Hong-Van; Minn Andy J; Massagué Joan
Cyclin-dependent kinase inhibitors uncouple cell cycle progression from mitochondrial apoptotic functions in DNA-damaged cancer cells.
The Journal of biological chemistry 2005;280(36):32018-25.
2005: Minn Andy J; Gupta Gaorav P; Siegel Peter M; Bos Paula D; Shu Weiping; Giri Dilip D; Viale Agnes; Olshen Adam B; Gerald William L; Massagué Joan
Genes that mediate breast cancer metastasis to lung.
Nature 2005;436(7050):518-24.
2005: Minn Andy J; Kang Yibin; Serganova Inna; Gupta Gaorav P; Giri Dilip D; Doubrovin Mikhail; Ponomarev Vladimir; Gerald William L; Blasberg Ronald; Massagué Joan
Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors.
The Journal of clinical investigation 2005;115(1):44-55.
2005: Gupta G P; Minn A J; Kang Y; Siegel P M; Serganova I; Cordón-Cardo C; Olshen A B; Gerald W L; Massagué J
Identifying site-specific metastasis genes and functions.
Cold Spring Harbor symposia on quantitative biology 2005;70():149-58.
2004: Gupta Gaorav P; Massagué Joan
Platelets and metastasis revisited: a novel fatty link.
The Journal of clinical investigation 2004;114(12):1691-3.
2004: Massagué Joan
G1 cell-cycle control and cancer.
Nature 2004;432(7015):298-306.
2004: Scandura Joseph M; Boccuni Piernicola; Massagué Joan; Nimer Stephen D
Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(42):15231-6.
2004: Kang Yibin; Massagué Joan
Epithelial-mesenchymal transitions: twist in development and metastasis.
Cell 2004;118(3):277-9.
2004: Calonge María Julia; Seoane Joan; Massagué Joan
Opposite Smad and chicken ovalbumin upstream promoter transcription factor inputs in the regulation of the collagen VII gene promoter by transforming growth factor-beta.
The Journal of biological chemistry 2004;279(22):23759-65.
2004: Seoane Joan; Le Hong-Van; Shen Lijian; Anderson Stewart A; Massagué Joan
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
Cell 2004;117(2):211-23.
2004: Xu Lan; Massagué Joan
Nucleocytoplasmic shuttling of signal transducers.
Nature reviews. Molecular cell biology 2004;5(3):209-19.
2003: Siegel Peter M; Massagué Joan
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
Nature reviews. Cancer 2003;3(11):807-21.
2003: Massagué Joan
New concepts in tissue-specific metastases.
Clinical advances in hematology & oncology : H&O 2003;1(10):576-7.
2003: Xu Lan; Alarcón Claudio; Cöl Seda; Massagué Joan
Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import.
The Journal of biological chemistry 2003;278(43):42569-77.
2003: Siegel Peter M; Shu Weiping; Massagué Joan
Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression.
The Journal of biological chemistry 2003;278(37):35444-50.
2003: Siegel Peter M; Shu Weiping; Cardiff Robert D; Muller William J; Massagué Joan
Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8430-5.
2003: Kang Yibin; Siegel Peter M; Shu Weiping; Drobnjak Maria; Kakonen Sanna M; Cordón-Cardo Carlos; Guise Theresa A; Massagué Joan
A multigenic program mediating breast cancer metastasis to bone.
Cancer cell 2003;3(6):537-49.
2003: Shi Yigong; Massagué Joan
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
Cell 2003;113(6):685-700.
2003: Chai Jijie; Wu Jia-Wei; Yan Nieng; Massagué Joan; Pavletich Nikola P; Shi Yigong
Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding.
The Journal of biological chemistry 2003;278(22):20327-31.
2003: Kang Yibin; Chen Chang-Rung; Massagué Joan
A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.
Molecular cell 2003;11(4):915-26.
2003: García-Sainz J Adolfo; Vilchis-Landeros M Magdalena; Juárez Patricia; López-Casillas Fernando; Hernández-Pando Rogelio; Massagué Joan
[Receptors and functions of TGF-beta, a crucial cytokine in wound healing]
Gaceta médica de México 2003;139(2):126-43.
2002: Seoane Joan; Le Hong-Van; Massagué Joan
Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage.
Nature 2002;419(6908):729-34.
2002: Blain Stacy W; Massagué Joan
Breast cancer banishes p27 from nucleus.
Nature medicine 2002;8(10):1076-8.
2002: Xu Lan; Kang Yibin; Cöl Seda; Massagué Joan
Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus.
Molecular cell 2002;10(2):271-82.
2002: Chen Chang-Rung; Kang Yibin; Siegel Peter M; Massagué Joan
E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression.
Cell 2002;110(1):19-32.
2002: López-Rovira Teresa; Chalaux Elisabet; Massagué Joan; Rosa Jose Luis; Ventura Francesc
Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene.
The Journal of biological chemistry 2002;277(5):3176-85.
2001: Wu J W; Hu M; Chai J; Seoane J; Huse M; Li C; Rigotti D J; Kyin S; Muir T W; Fairman R; Massagué J; Shi Y
Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling.
Molecular cell 2001;8(6):1277-89.
2001: Huse M; Muir T W; Xu L; Chen Y G; Kuriyan J; Massagué J
The TGF beta receptor activation process: an inhibitor- to substrate-binding switch.
Molecular cell 2001;8(3):671-82.
2001: Seoane J; Pouponnot C; Staller P; Schader M; Eilers M; Massagué J
TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b.
Nature cell biology 2001;3(4):400-8.
2001: Staller P; Peukert K; Kiermaier A; Seoane J; Lukas J; Karsunky H; Möröy T; Bartek J; Massagué J; Hänel F; Eilers M
Repression of p15INK4b expression by Myc through association with Miz-1.
Nature cell biology 2001;3(4):392-9.
2001: Lo R S; Wotton D; Massagué J
Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF.
The EMBO journal 2001;20(1-2):128-36.
2001: Chen C R; Kang Y; Massagué J
Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):992-9.
2000: Massagué J
How cells read TGF-beta signals.
Nature reviews. Molecular cell biology 2000;1(3):169-78.
2000: Massagué J; Blain S W; Lo R S
TGFbeta signaling in growth control, cancer, and heritable disorders.
Cell 2000;103(2):295-309.
2000: Blain S W; Massagué J
Different sensitivity of the transforming growth factor-beta cell cycle arrest pathway to c-Myc and MDM-2.
The Journal of biological chemistry 2000;275(41):32066-70.
2000: Xu L; Chen Y G; Massagué J
The nuclear import function of Smad2 is masked by SARA and unmasked by TGFbeta-dependent phosphorylation.
Nature cell biology 2000;2(8):559-62.
2000: Massagué J; Wotton D
Transcriptional control by the TGF-beta/Smad signaling system.
The EMBO journal 2000;19(8):1745-54.
2000: Massagué J; Chen Y G
Controlling TGF-beta signaling.
Genes & development 2000;14(6):627-44.
2000: Hata A; Seoane J; Lagna G; Montalvo E; Hemmati-Brivanlou A; Massagué J
OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways.
Cell 2000;100(2):229-40.
2000: Wu G; Chen Y G; Ozdamar B; Gyuricza C A; Chong P A; Wrana J L; Massagué J; Shi Y
Structural basis of Smad2 recognition by the Smad anchor for receptor activation.
Science (New York, N.Y.) 2000;287(5450):92-7.
1999: Wotton D; Lo R S; Swaby L A; Massagué J
Multiple modes of repression by the Smad transcriptional corepressor TGIF.
The Journal of biological chemistry 1999;274(52):37105-10.
1999: Lo R S; Massagué J
Ubiquitin-dependent degradation of TGF-beta-activated smad2.
Nature cell biology 1999;1(8):472-8.
1999: Pasche B; Kolachana P; Nafa K; Satagopan J; Chen Y G; Lo R S; Brener D; Yang D; Kirstein L; Oddoux C; Ostrer H; Vineis P; Varesco L; Jhanwar S; Luzzatto L; Massagué J; Offit K
TbetaR-I(6A) is a candidate tumor susceptibility allele.
Cancer research 1999;59(22):5678-82.
1999: Calonge M J; Massagué J
Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells.
The Journal of biological chemistry 1999;274(47):33637-43.
1999: Warner B J; Blain S W; Seoane J; Massagué J
Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.
Molecular and cellular biology 1999;19(9):5913-22.
1999: Wotton D; Lo R S; Lee S; Massagué J
A Smad transcriptional corepressor.
Cell 1999;97(1):29-39.
1999: Kretzschmar M; Doody J; Timokhina I; Massagué J
A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras.
Genes & development 1999;13(7):804-16.
1999: Ulloa L; Doody J; Massagué J
Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.
Nature 1999;397(6721):710-3.
1999: Huse M; Chen Y G; Massagué J; Kuriyan J
Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12.
Cell 1999;96(3):425-36.
1999: Chen Y G; Massagué J
Smad1 recognition and activation by the ALK1 group of transforming growth factor-beta family receptors.
The Journal of biological chemistry 1999;274(6):3672-7.
1999: Iavarone A; Massagué J
E2F and histone deacetylase mediate transforming growth factor beta repression of cdc25A during keratinocyte cell cycle arrest.
Molecular and cellular biology 1999;19(1):916-22.
1998: Shi Y; Wang Y F; Jayaraman L; Yang H; Massagué J; Pavletich N P
Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling.
Cell 1998;94(5):585-94.
1998: Pouponnot C; Jayaraman L; Massagué J
Physical and functional interaction of SMADs and p300/CBP.
The Journal of biological chemistry 1998;273(36):22865-8.
1998: Chen Y G; Hata A; Lo R S; Wotton D; Shi Y; Pavletich N; Massagué J
Determinants of specificity in TGF-beta signal transduction.
Genes & development 1998;12(14):2144-52.
1998: Pasche B; Luo Y; Rao P H; Nimer S D; Dmitrovsky E; Caron P; Luzzatto L; Offit K; Cordon-Cardo C; Renault B; Satagopan J M; Murty V V; Massagué J
Type I transforming growth factor beta receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract.
Cancer research 1998;58(13):2727-32.
1998: Hata A; Shi Y; Massagué J
TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.
Molecular medicine today 1998;4(6):257-62.
1998: Kretzschmar M; Massagué J
SMADs: mediators and regulators of TGF-beta signaling.
Current opinion in genetics & development 1998;8(1):103-11.
1998: Lo R S; Chen Y G; Shi Y; Pavletich N P; Massagué J
The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors.
The EMBO journal 1998;17(4):996-1005.
1998: Hata A; Lagna G; Massagué J; Hemmati-Brivanlou A
Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor.
Genes & development 1998;12(2):186-97.
1998: Massagué J
TGF-beta signal transduction.
Annual review of biochemistry 1998;67():753-91.
1997: Liu F; Pouponnot C; Massagué J
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.
Genes & development 1997;11(23):3157-67.
1997: Kretzschmar M; Doody J; Massagué J
Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1.
Nature 1997;389(6651):618-22.
1997: Blain S W; Montalvo E; Massagué J
Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4.
The Journal of biological chemistry 1997;272(41):25863-72.
1997: Zou H; Wieser R; Massagué J; Niswander L
Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage.
Genes & development 1997;11(17):2191-203.
1997: Shi Y; Hata A; Lo R S; Massagué J; Pavletich N P
A structural basis for mutational inactivation of the tumour suppressor Smad4.
Nature 1997;388(6637):87-93.
1997: Hata A; Lo R S; Wotton D; Lagna G; Massagué J
Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4.
Nature 1997;388(6637):82-7.
1997: Arribas J; López-Casillas F; Massagué J
Role of the juxtamembrane domains of the transforming growth factor-alpha precursor and the beta-amyloid precursor protein in regulated ectodomain shedding.
The Journal of biological chemistry 1997;272(27):17160-5.
1997: Iavarone A; Massagué J
Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15.
Nature 1997;387(6631):417-22.
1997: Kretzschmar M; Liu F; Hata A; Doody J; Massagué J
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.
Genes & development 1997;11(8):984-95.
1997: Reynisdóttir I; Massagué J
The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.
Genes & development 1997;11(4):492-503.
1997: Zou H; Choe K M; Lu Y; Massagué J; Niswander L
BMP signaling and vertebrate limb development.
Cold Spring Harbor symposia on quantitative biology 1997;62():269-72.
1996: Luo Y; Marx S O; Kiyokawa H; Koff A; Massagué J; Marks A R
Rapamycin resistance tied to defective regulation of p27Kip1.
Molecular and cellular biology 1996;16(12):6744-51.
1996: Lagna G; Hata A; Hemmati-Brivanlou A; Massagué J
Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.
Nature 1996;383(6603):832-6.
1996: Russo A A; Jeffrey P D; Patten A K; Massagué J; Pavletich N P
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
Nature 1996;382(6589):325-31.
1996: Massagué J
TGFbeta signaling: receptors, transducers, and Mad proteins.
Cell 1996;85(7):947-50.
1996: Ventura F; Liu F; Doody J; Massagué J
Interaction of transforming growth factor-beta receptor I with farnesyl-protein transferase-alpha in yeast and mammalian cells.
The Journal of biological chemistry 1996;271(24):13931-4.
1996: Liu F; Hata A; Baker J C; Doody J; Cárcamo J; Harland R M; Massagué J
A human Mad protein acting as a BMP-regulated transcriptional activator.
Nature 1996;381(6583):620-3.
1996: Arribas J; Coodly L; Vollmer P; Kishimoto T K; Rose-John S; Massagué J
Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors.
The Journal of biological chemistry 1996;271(19):11376-82.
1996: Lee M H; Nikolic M; Baptista C A; Lai E; Tsai L H; Massagué J
The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(8):3259-63.
1996: Orlow I; Iavarone A; Crider-Miller S J; Bonilla F; Latres E; Lee M H; Gerald W L; Massagué J; Weissman B E; Cordón-Cardó C
Cyclin-dependent kinase inhibitor p57KIP2 in soft tissue sarcomas and Wilms'tumors.
Cancer research 1996;56(6):1219-21.
1996: Reid L H; Crider-Miller S J; West A; Lee M H; Massagué J; Weissman B E
Genomic organization of the human p57KIP2 gene and its analysis in the G401 Wilms' tumor assay.
Cancer research 1996;56(6):1214-8.
1996: Weis-Garcia F; Massagué J
Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling.
The EMBO journal 1996;15(2):276-89.
1996: Massagué J; Weis-Garcia F
Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals.
Cancer surveys 1996;27():41-64.
1995: Reynisdóttir I; Polyak K; Iavarone A; Massagué J
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.
Genes & development 1995;9(15):1831-45.
1995: Liu F; Ventura F; Doody J; Massagué J
Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.
Molecular and cellular biology 1995;15(7):3479-86.
1995: Jeffrey P D; Russo A A; Polyak K; Gibbs E; Hurwitz J; Massagué J; Pavletich N P
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.
Nature 1995;376(6538):313-20.
1995: Wieser R; Wrana J L; Massagué J
GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.
The EMBO journal 1995;14(10):2199-208.
1995: Luo Y; Hurwitz J; Massagué J
Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1.
Nature 1995;375(6527):159-61.
1995: Cárcamo J; Zentella A; Massagué J
Disruption of transforming growth factor beta signaling by a mutation that prevents transphosphorylation within the receptor complex.
Molecular and cellular biology 1995;15(3):1573-81.
1995: Lee M H; Reynisdóttir I; Massagué J
Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.
Genes & development 1995;9(6):639-49.
1995: Vivien D; Attisano L; Wrana J L; Massagué J
Signaling activity of homologous and heterologous transforming growth factor-beta receptor kinase complexes.
The Journal of biological chemistry 1995;270(13):7134-41.
1995: Letsou A; Arora K; Wrana J L; Simin K; Twombly V; Jamal J; Staehling-Hampton K; Hoffmann F M; Gelbart W M; Massagué J
Drosophila Dpp signaling is mediated by the punt gene product: a dual ligand-binding type II receptor of the TGF beta receptor family.
Cell 1995;80(6):899-908.
1995: Arribas J; Massagué J
Transforming growth factor-alpha and beta-amyloid precursor protein share a secretory mechanism.
The Journal of cell biology 1995;128(3):433-41.
1994: Ventura F; Doody J; Liu F; Wrana J L; Massagué J
Reconstitution and transphosphorylation of TGF-beta receptor complexes.
The EMBO journal 1994;13(23):5581-9.
1994: Kato J Y; Matsuoka M; Polyak K; Massagué J; Sherr C J
Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.
Cell 1994;79(3):487-96.
1994: Wrana J L; Attisano L; Wieser R; Ventura F; Massagué J
Mechanism of activation of the TGF-beta receptor.
Nature 1994;370(6488):341-7.
1994: Brummel T J; Twombly V; Marqués G; Wrana J L; Newfeld S J; Attisano L; Massagué J; O'Connor M B; Gelbart W M
Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila.
Cell 1994;78(2):251-61.
1994: Penton A; Chen Y; Staehling-Hampton K; Wrana J L; Attisano L; Szidonya J; Cassill J A; Massagué J; Hoffmann F M
Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor.
Cell 1994;78(2):239-50.
1994: Polyak K; Lee M H; Erdjument-Bromage H; Koff A; Roberts J M; Tempst P; Massagué J
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.
Cell 1994;78(1):59-66.
1994: Cárcamo J; Weis F M; Ventura F; Wieser R; Wrana J L; Attisano L; Massagué J
Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.
Molecular and cellular biology 1994;14(6):3810-21.
1994: Attisano L; Wrana J L; López-Casillas F; Massagué J
TGF-beta receptors and actions.
Biochimica et biophysica acta 1994;1222(1):71-80.
1994: Mathew S; Murty V V; Cheifetz S; George D; Massagué J; Chaganti R S
Transforming growth factor receptor gene TGFBR2 maps to human chromosome band 3p22.
Genomics 1994;20(1):114-5.
1994: Wrana J L; Tran H; Attisano L; Arora K; Childs S R; Massagué J; O'Connor M B
Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex.
Molecular and cellular biology 1994;14(2):944-50.
1994: López-Casillas F; Payne H M; Andres J L; Massagué J
Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites.
The Journal of cell biology 1994;124(4):557-68.
1994: Roberts J M; Koff A; Polyak K; Firpo E; Collins S; Ohtsubo M; Massagué J
Cyclins, Cdks, and cyclin kinase inhibitors.
Cold Spring Harbor symposia on quantitative biology 1994;59():31-8.
1993: Wieser R; Attisano L; Wrana J L; Massagué J
Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region.
Molecular and cellular biology 1993;13(12):7239-47.
1993: Attisano L; Cárcamo J; Ventura F; Weis F M; Massagué J; Wrana J L
Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors.
Cell 1993;75(4):671-80.
1993: Childs S R; Wrana J L; Arora K; Attisano L; O'Connor M B; Massagué J
Identification of a Drosophila activin receptor.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9475-9.
1993: Bosenberg M W; Massagué J
Juxtacrine cell signaling molecules.
Current opinion in cell biology 1993;5(5):832-8.
1993: López-Casillas F; Wrana J L; Massagué J
Betaglycan presents ligand to the TGF beta signaling receptor.
Cell 1993;73(7):1435-44.
1993: Bosenberg M W; Pandiella A; Massagué J
Activated release of membrane-anchored TGF-alpha in the absence of cytosol.
The Journal of cell biology 1993;122(1):95-101.
1993: Koff A; Ohtsuki M; Polyak K; Roberts J M; Massagué J
Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.
Science (New York, N.Y.) 1993;260(5107):536-9.
1993: Massagué J; Pandiella A
Membrane-anchored growth factors.
Annual review of biochemistry 1993;62():515-41.
1992: Bosenberg M W; Pandiella A; Massagué J
The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGF alpha into soluble growth factor.
Cell 1992;71(7):1157-65.
1992: Wrana J L; Attisano L; Cárcamo J; Zentella A; Doody J; Laiho M; Wang X F; Massagué J
TGF beta signals through a heteromeric protein kinase receptor complex.
Cell 1992;71(6):1003-14.
1992: Pandiella A; Bosenberg M W; Huang E J; Besmer P; Massagué J
Cleavage of membrane-anchored growth factors involves distinct protease activities regulated through common mechanisms.
The Journal of biological chemistry 1992;267(33):24028-33.
1992: Cheifetz S; Bellón T; Calés C; Vera S; Bernabeu C; Massagué J; Letarte M
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.
The Journal of biological chemistry 1992;267(27):19027-30.
1992: Zentella A; Massagué J
Transforming growth factor beta induces myoblast differentiation in the presence of mitogens.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):5176-80.
1992: Massagué J; Andres J; Attisano L; Cheifetz S; López-Casillas F; Ohtsuki M; Wrana J L
TGF-beta receptors.
Molecular reproduction and development 1992;32(2):99-104.
1992: Massagué J
Receptors for the TGF-beta family.
Cell 1992;69(7):1067-70.
1992: Andres J L; DeFalcis D; Noda M; Massagué J
Binding of two growth factor families to separate domains of the proteoglycan betaglycan.
The Journal of biological chemistry 1992;267(9):5927-30.
1992: Massagué J; Weinberg R A
Negative regulators of growth.
Current opinion in genetics & development 1992;2(1):28-32.
1992: Ohtsuki M; Massagué J
Evidence for the involvement of protein kinase activity in transforming growth factor-beta signal transduction.
Molecular and cellular biology 1992;12(1):261-5.
1992: Attisano L; Wrana J L; Cheifetz S; Massagué J
Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors.
Cell 1992;68(1):97-108.
1992: Massagué J; Cheifetz S; Laiho M; Ralph D A; Weis F M; Zentella A
Transforming growth factor-beta.
Cancer surveys 1992;12():81-103.
1992: Wrana J L; Cárcamo J; Attisano L; Cheifetz S; Zentella A; López-Casillas F; Massagué J
The type II TGF-beta receptor signals diverse responses in cooperation with the type I receptor.
Cold Spring Harbor symposia on quantitative biology 1992;57():81-6.
1991: Andres J L; Rönnstrand L; Cheifetz S; Massagué J
Purification of the transforming growth factor-beta (TGF-beta) binding proteoglycan betaglycan.
The Journal of biological chemistry 1991;266(34):23282-7.
1991: Cheifetz S; Massagué J
Isoform-specific transforming growth factor-beta binding proteins with membrane attachments sensitive to phosphatidylinositol-specific phospholipase C.
The Journal of biological chemistry 1991;266(31):20767-72.
1991: López-Casillas F; Cheifetz S; Doody J; Andres J L; Lane W S; Massagué J
Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system.
Cell 1991;67(4):785-95.
1991: Zentella A; Weis F M; Ralph D A; Laiho M; Massagué J
Early gene responses to transforming growth factor-beta in cells lacking growth-suppressive RB function.
Molecular and cellular biology 1991;11(10):4952-8.
1991: Laiho M; Weis F M; Boyd F T; Ignotz R A; Massagué J
Responsiveness to transforming growth factor-beta (TGF-beta) restored by genetic complementation between cells defective in TGF-beta receptors I and II.
The Journal of biological chemistry 1991;266(14):9108-12.
1991: Pandiella A; Massagué J
Multiple signals activate cleavage of the membrane transforming growth factor-alpha precursor.
The Journal of biological chemistry 1991;266(9):5769-73.
1991: Pandiella A; Massagué J
Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):1726-30.
1991: Laiho M; Rönnstrand L; Heino J; Decaprio J A; Ludlow J W; Livingston D M; Massagué J
Control of junB and extracellular matrix protein expression by transforming growth factor-beta 1 is independent of simian virus 40 T antigen-sensitive growth-sensitive growth-inhibitory events.
Molecular and cellular biology 1991;11(2):972-8.
1990: Massagué J
Transforming growth factor-alpha. A model for membrane-anchored growth factors.
The Journal of biological chemistry 1990;265(35):21393-6.
1990: Cheifetz S; Hernandez H; Laiho M; ten Dijke P; Iwata K K; Massagué J
Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms.
The Journal of biological chemistry 1990;265(33):20533-8.
1990: Laiho M; Weis M B; Massagué J
Concomitant loss of transforming growth factor (TGF)-beta receptor types I and II in TGF-beta-resistant cell mutants implicates both receptor types in signal transduction.
The Journal of biological chemistry 1990;265(30):18518-24.
1990: Laiho M; DeCaprio J A; Ludlow J W; Livingston D M; Massagué J
Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation.
Cell 1990;62(1):175-85.
1990: Heino J; Massagué J
Cell adhesion to collagen and decreased myogenic gene expression implicated in the control of myogenesis by transforming growth factor beta.
The Journal of biological chemistry 1990;265(18):10181-4.
1990: Teixido J; Wong S T; Lee D C; Massagué J
Generation of transforming growth factor-alpha from the cell surface by an O-glycosylation-independent multistep process.
The Journal of biological chemistry 1990;265(11):6410-5.
1990: Massagué J
The transforming growth factor-beta family.
Annual review of cell biology 1990;6():597-641.
1990: Massagué J; Cheifetz S; Boyd F T; Andres J L
TGF-beta receptors and TGF-beta binding proteoglycans: recent progress in identifying their functional properties.
Annals of the New York Academy of Sciences 1990;593():59-72.
1990: Boyd F T; Cheifetz S; Andres J; Laiho M; Massagué J
Transforming growth factor-beta receptors and binding proteoglycans.
Journal of cell science. Supplement 1990;13():131-8.
1989: Heino J; Massagué J
Transforming growth factor-beta switches the pattern of integrins expressed in MG-63 human osteosarcoma cells and causes a selective loss of cell adhesion to laminin.
The Journal of biological chemistry 1989;264(36):21806-11.
1989: Andres J L; Stanley K; Cheifetz S; Massagué J
Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta.
The Journal of cell biology 1989;109(6 Pt 1):3137-45.
1989: Cheifetz S; Massagué J
Transforming growth factor-beta (TGF-beta) receptor proteoglycan. Cell surface expression and ligand binding in the absence of glycosaminoglycan chains.
The Journal of biological chemistry 1989;264(20):12025-8.
1989: Boyd F T; Massagué J
Transforming growth factor-beta inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor.
The Journal of biological chemistry 1989;264(4):2272-8.
1989: Heino J; Ignotz R A; Hemler M E; Crouse C; Massagué J
Regulation of cell adhesion receptors by transforming growth factor-beta. Concomitant regulation of integrins that share a common beta 1 subunit.
The Journal of biological chemistry 1989;264(1):380-8.
1989: Ignotz R A; Heino J; Massagué J
Regulation of cell adhesion receptors by transforming growth factor-beta. Regulation of vitronectin receptor and LFA-1.
The Journal of biological chemistry 1989;264(1):389-92.
1988: Cheifetz S; Ling N; Guillemin R; Massagué J
A surface component on GH3 pituitary cells that recognizes transforming growth factor-beta, activin, and inhibin.
The Journal of biological chemistry 1988;263(33):17225-8.
1988: Cheifetz S; Andres J L; Massagué J
The transforming growth factor-beta receptor type III is a membrane proteoglycan. Domain structure of the receptor.
The Journal of biological chemistry 1988;263(32):16984-91.
1988: Cheifetz S; Bassols A; Stanley K; Ohta M; Greenberger J; Massagué J
Heterodimeric transforming growth factor beta. Biological properties and interaction with three types of cell surface receptors.
The Journal of biological chemistry 1988;263(22):10783-9.
1988: Teixidó J; Massagué J
Structural properties of a soluble bioactive precursor for transforming growth factor-alpha.
The Journal of biological chemistry 1988;263(8):3924-9.
1988: Bassols A; Massagué J
Transforming growth factor beta regulates the expression and structure of extracellular matrix chondroitin/dermatan sulfate proteoglycans.
The Journal of biological chemistry 1988;263(6):3039-45.
1987: Ignotz R A; Massagué J
Cell adhesion protein receptors as targets for transforming growth factor-beta action.
Cell 1987;51(2):189-97.
1987: Ohta M; Greenberger J S; Anklesaria P; Bassols A; Massagué J
Two forms of transforming growth factor-beta distinguished by multipotential haematopoietic progenitor cells.
Nature 1987;329(6139):539-41.
1987: Massagué J; Cheifetz S; Ignotz R A; Boyd F T
Multiple type-beta transforming growth factors and their receptors.
Journal of cellular physiology. Supplement 1987;Suppl 5():43-7.

Sign-in to see more

Sign-in free and Explore the Exciting World of BiomedExperts:

NetworkView

Joan Massagué

Research Profile (preview)

Chemicals & Drugs

Physiology

Anatomy

Concepts & Ideas

Genes & Molecular Sequences

Living Beings

Phenomena

Network (preview)

Publications

Sign in free and see...

Visualized networks:

GeoTargeted Searches:

Research Profiles:

Geonetwork of Joan Massagué (preview)

All Publications