Yasuhiro Masubuchi

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Fujiyama Nobuhiro; Shitara Yoshihisa; Ito Kousei; Masubuchi Yasuhiro; Horie Toshiharu
Down-regulation of hepatic transporters for BSP in rats with indomethacin-induced intestinal injury.
Masubuchi Yasuhiro; Kawasaki Mamiko; Horie Toshiharu
Down-regulation of hepatic cytochrome P450 enzymes associated with cisplatin-induced acute renal failure in male rats.
Tachibana Masaya; Tanaka Makoto; Masubuchi Yasuhiro; Horie Toshiharu
Acyl glucuronidation of fluoroquinolone antibiotics by the UDP-glucuronosyltransferase 1A subfamily in human liver microsomes.

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2007: Fujiyama Nobuhiro; Shitara Yoshihisa; Ito Kousei; Masubuchi Yasuhiro; Horie Toshiharu
Down-regulation of hepatic transporters for BSP in rats with indomethacin-induced intestinal injury.
Biological & pharmaceutical bulletin 2007;30(3):556-61.
2006: Masubuchi Yasuhiro; Kawasaki Mamiko; Horie Toshiharu
Down-regulation of hepatic cytochrome P450 enzymes associated with cisplatin-induced acute renal failure in male rats.
Archives of toxicology 2006;80(6):347-53.
2005: Tachibana Masaya; Tanaka Makoto; Masubuchi Yasuhiro; Horie Toshiharu
Acyl glucuronidation of fluoroquinolone antibiotics by the UDP-glucuronosyltransferase 1A subfamily in human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(6):803-11.
2005: Masubuchi Yasuhiro; Suda Chieko; Horie Toshiharu
Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice.
Journal of hepatology 2005;42(1):110-6.
2004: Masubuchi Yasuhiro; Horie Toshiharu
Endotoxin-mediated disturbance of hepatic cytochrome P450 function and development of endotoxin tolerance in the rat model of dextran sulfate sodium-induced experimental colitis.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(4):437-41.
2003: Masubuchi Yasuhiro; Horie Toshiharu
Resistance to indomethacin-induced down-regulation of hepatic cytochrome P450 enzymes in the mice with non-functional Toll-like receptor 4.
Journal of hepatology 2003;39(3):349-56.
2003: Ji Bin; Masubuchi Y; Horie T
The relationship between oxidative metabolism and lipid peroxidation in rat liver microsomes.
Research communications in molecular pathology and pharmacology 2003;113-114():181-92.
2002: Masubuchi Yasuhiro; Ose Atsushi; Horie Toshiharu
Diclofenac-induced inactivation of CYP3A4 and its stimulation by quinidine.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(10):1143-8.
2002: Doi Hirokazu; Iwasaki Hiromi; Masubuchi Yasuhiro; Nishigaki Ryuichiro; Horie Toshiharu
Chemiluminescence associated with the oxidative metabolism of salicylic acid in rat liver microsomes.
Chemico-biological interactions 2002;140(2):109-19.
2002: Yamamoto K; Masubuchi Y; Narimatsu S; Kobayashi S; Horie T
Toxicity of ethacrynic acid in isolated rat hepatocytes.
Toxicology in vitro : an international journal published in association with BIBRA 2002;16(2):151-8.
2002: Masubuchi Yasuhiro; Masuda Emi; Horie Toshiharu
Multiple mechanisms in indomethacin-induced impairment of hepatic cytochrome P450 enzymes in rats.
Gastroenterology 2002;122(3):774-83.
2002: Masubuchi Yasuhiro; Nakayama Shintaro; Horie Toshiharu
Role of mitochondrial permeability transition in diclofenac-induced hepatocyte injury in rats.
Hepatology (Baltimore, Md.) 2002;35(3):544-51.
2002: Isozaki Masanao; Masubuchi Yasuhiro; Horie Toshiharu
Evaluation of drug-induced hepatotoxicity by plasma retinol binding protein.
In vivo (Athens, Greece) 2002;16(1):61-5.
2002: Isozaki Masanao; Ito Kousei; Masubuchi Yasuhiro; Horie Toshiharu
Plasma retinol binding protein for monitoring the acetaminophen-induced hepatotoxicity.
Drug metabolism and pharmacokinetics 2002;17(6):540-5.
2001: Masubuchi Y; Nakano T; Ose A; Horie T
Differential selectivity in carbamazepine-induced inactivation of cytochrome P450 enzymes in rat and human liver.
Archives of toxicology 2001;75(9):538-43.
2001: Narimatsu S; Arai T; Masubuchi Y; Horie T; Hosokawa M; Ueno K; Kataoka H; Yamamoto S; Ishikawa T; Cho A K
Inactivation of rat cytochrome P450 2D enzyme by a further metabolite of 4-hydroxypropranolol, the major and active metabolite of propranolol.
Biological & pharmaceutical bulletin 2001;24(9):988-94.
2001: Masubuchi Y; Ose A; Horie T
Mechanism-based inactivation of CYP2C11 by diclofenac.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(9):1190-5.
2001: Gao F; Nakamaru M; Masubuchi Y; Horie T
Protective effect of a synthetic analog of prostaglandin E(1) on the small intestinal damage induced by the administration of methotrexate to rats.
Journal of pharmaceutical sciences 2001;90(8):1040-8.
2001: Ji B; Masubuchi Y; Horie T
A possible mechanism of naproxen-induced lipid peroxidation in rat liver microsomes.
Pharmacology & toxicology 2001;89(1):43-8.
2001: Yamamoto K; Masubuchi Y; Narimatsu S; Kobayashi S; Horie T
Rat liver microsomal lipid peroxidation produced during the oxidative metabolism of ethacrynic acid.
Pharmacology & toxicology 2001;88(4):176-80.
2001: Isozaki M; Masubuchi Y; Horie T
Retinol binding protein in plasma to evaluate the hepatotoxicity of rats treated with CCl4.
Research communications in molecular pathology and pharmacology 2001;110(5-6):303-10.
2001: Narimatsu S; Kobayashi N; Asaoka K; Masubuchi Y; Horie T; Hosokawa M; Ishikawa T; Ohmori S; Kitada M; Miyano J; Kataoka H; Yamamoto S
High-performance liquid chromatographic analysis of the sulfation of 4-hydroxypropranolol enantiomers by monkey liver cytosol.
Chirality 2001;13(3):140-7.
2000: Narimatsu S; Kobayashi N; Masubuchi Y; Horie T; Kakegawa T; Kobayashi H; Hardwick J P; Gonzalez F J; Shimada N; Ohmori S; Kitada M; Asaoka K; Kataoka H; Yamamoto S; Satoh T
Species difference in enantioselectivity for the oxidation of propranolol by cytochrome P450 2D enzymes.
Chemico-biological interactions 2000;127(1):73-90.
2000: Masubuchi Y; Yamada S; Horie T
Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs.
The Journal of pharmacology and experimental therapeutics 2000;292(3):982-7.
1999: Masubuchi Y; Horie T
Mechanism-based inactivation of cytochrome P450s 1A2 and 3A4 by dihydralazine in human liver microsomes.
Chemical research in toxicology 1999;12(10):1028-32.
1999: Masubuchi Y; Yamada S; Horie T
Diphenylamine as an important structure of nonsteroidal anti-inflammatory drugs to uncouple mitochondrial oxidative phosphorylation.
Biochemical pharmacology 1999;58(5):861-5.
1999: Narimatsu S; Yamamoto S; Kato R; Masubuchi Y; Horie T
Contribution of flavin-containing monooxygenase and cytochrome P450 to imipramine N-oxidation in rat hepatic microsomes.
Biological & pharmaceutical bulletin 1999;22(6):567-71.
1999: Masubuchi Y; Konishi M; Horie T
Imipramine- and mianserin-induced acute cell injury in primary cultured rat hepatocytes: implication of different cytochrome P450 enzymes.
Archives of toxicology 1999;73(3):147-51.
1999: Narimatsu S; Yamamoto S; Koitabashi T; Kato R; Masubuchi Y; Suzuki T; Horie T
Biphasic kinetics of imipramine N-oxidation in rat brain microsomes.
Biological & pharmaceutical bulletin 1999;22(3):253-6.
1998: Masubuchi Y; Saito H; Horie T
Structural requirements for the hepatotoxicity of nonsteroidal anti-inflammatory drugs in isolated rat hepatocytes.
The Journal of pharmacology and experimental therapeutics 1998;287(1):208-13.
1998: Doi H; Masubuchi Y; Narimatsu S; Nishigaki R; Horie T
Salicylic acid-induced lipid peroxidation in rat liver microsomes.
Research communications in molecular pathology and pharmacology 1998;100(3):265-71.
1998: Masubuchi Y; Horie T
Dihydralazine-induced inactivation of cytochrome P450 enzymes in rat liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(4):338-42.
1998: Horie T; Nakamaru M; Masubuchi Y
Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice.
Life sciences 1998;62(15):1333-8.
1998: Nakamaru M; Masubuchi Y; Narimatsu S; Awazu S; Horie T
Evaluation of damaged small intestine of mouse following methotrexate administration.
Cancer chemotherapy and pharmacology 1998;41(2):98-102.
1997: Masubuchi Y; Iwasa T; Hosokawa S; Suzuki T; Horie T; Imaoka S; Funae Y; Narimatsu S
Selective deficiency of debrisoquine 4-hydroxylase activity in mouse liver microsomes.
The Journal of pharmacology and experimental therapeutics 1997;282(3):1435-41.
1997: Narimatsu S; Arai T; Watanabe T; Masubuchi Y; Horie T; Suzuki T; Ishikawa T; Tsutsui M; Kumagai Y; Cho A K
Covalent binding of a reactive metabolite derived from propranolol and its active metabolite 4-hydroxypropranolol to hepatic microsomal proteins of the rat.
Chemical research in toxicology 1997;10(3):289-95.
1996: Narimatsu S; Mizukami T; Huang Y; Masubuchi Y; Suzuki T
In-vitro metabolic interaction of bunitrolol enantiomers in rabbit liver microsomes.
The Journal of pharmacy and pharmacology 1996;48(11):1185-9.
1996: Narimatsu S; Gotoh M; Masubuchi Y; Horie T; Ohmori S; Kitada M; Kageyama T; Asaoka K; Yamamoto I; Suzuki T
Stereoselectivity in bunitrolol 4-hydroxylation in liver microsomes from marmosets and Japanese monkeys.
Biological & pharmaceutical bulletin 1996;19(11):1429-33.
1996: Masubuchi Y; Igarashi S; Suzuki T; Horie T; Narimatsu S
Imipramine-induced inactivation of a cytochrome P450 2D enzyme in rat liver microsomes: in relation to covalent binding of its reactive intermediate.
The Journal of pharmacology and experimental therapeutics 1996;279(2):724-31.
1996: Masubuchi Y; Iwasa T; Fujita S; Suzuki T; Horie T; Narimatsu S
Regioselectivity and substrate concentration-dependency of involvement of the CYP2D subfamily in oxidative metabolism of amitriptyline and nortriptyline in rat liver microsomes.
The Journal of pharmacy and pharmacology 1996;48(9):925-9.
1996: Narimatsu S; Mochida M; Matsumoto T; Masubuchi Y; Horie T; Nagata K; Funae Y; Cho A K; Suzuki T
Cytochrome P450 enzymes involved in the enhancement of propranolol N-desisopropylation after repeated administration of propranolol in rats.
Chemico-biological interactions 1996;101(3):207-24.
1996: Masubuchi Y; Yamamoto K; Suzuki T; Horie T; Narimatsu S
Characterization of the oxidation reactions catalyzed by CYP2D enzyme in rat renal microsomes.
Life sciences 1996;58(26):2431-7.
1996: Narimatsu S; Tachibana M; Masubuchi Y; Suzuki T
Cytochrome P4502D and -2C enzymes catalyze the oxidative N-demethylation of the parkinsonism-inducing substance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in rat liver microsomes.
Chemical research in toxicology 1996;9(1):93-8.
1995: Kariya S; Isozaki S; Masubuchi Y; Suzuki T; Narimatsu S
Possible pharmacokinetic and pharmacodynamic factors affecting parkinsonism inducement by cinnarizine and flunarizine.
Biochemical pharmacology 1995;50(10):1645-50.
1995: Masubuchi Y; Takahashii C; Fujio N; Horie T; Suzuki T; Imaoka S; Funae Y; Narimatsu S
Inhibition and induction of cytochrome P450 isozymes after repetitive administration of imipramine in rats.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(9):999-1003.
1995: Narimatsu S; Tachibana M; Masubuchi Y; Imaoka S; Funae Y; Suzuki T
Cytochrome P450 isozymes involved in aromatic hydroxylation and side-chain N-desisopropylation of alprenolol in rat liver microsomes.
Biological & pharmaceutical bulletin 1995;18(8):1060-5.
1995: Narimatsu S; Watanabe T; Masubuchi Y; Horie T; Kumagai Y; Cho A K; Imaoka S; Funae Y; Ishikawa T; Suzuki T
Characterization of a chemically reactive propranolol metabolite that binds to microsomal proteins of rat liver.
Chemical research in toxicology 1995;8(5):721-8.
1994: Masubuchi Y; Narimatsu S; Hosokawa S; Suzuki T
Role of the CYP2D subfamily in metabolism-dependent covalent binding of propranolol to liver microsomal protein in rats.
Biochemical pharmacology 1994;48(10):1891-8.
1994: Masubuchi Y; Hosokawa S; Horie T; Suzuki T; Ohmori S; Kitada M; Narimatsu S
Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(6):909-15.
1994: Narimatsu S; Huang Y; Mizukami T; Masubuchi Y; Suzuki T
Development of a high-performance liquid chromatographic method for the analysis of enatiomer/enantiomer interaction in oxidative metabolism of bunitrolol in rat liver microsomes.
Analytical biochemistry 1994;222(1):256-61.
1994: Narimatsu S; Masubuchi Y; Hosokawa S; Ohmori S; Kitada M; Suzuki T
Involvement of a cytochrome P4502D subfamily in human liver microsomal bunitrolol 4-hydroxylation.
Biological & pharmaceutical bulletin 1994;17(6):803-7.
1994: Kagimoto N; Masubuchi Y; Fujita S; Narimatsu S; Suzuki T
Kinetic analysis of propranolol-induced impairment of its own metabolism in rats.
The Journal of pharmacy and pharmacology 1994;46(6):528-30.
1993: Masubuchi Y; Umeda S; Igarashi S; Fujita S; Narimatsu S; Suzuki T
Participation of the CYP2D subfamily in lidocaine 3-hydroxylation and formation of a reactive metabolite covalently bound to liver microsomal protein in rats.
Biochemical pharmacology 1993;46(10):1867-9.
1993: Masubuchi Y; Yamamoto L A; Uesaka M; Fujita S; Narimatsu S; Suzuki T
Substrate stereoselectivity and enantiomer/enantiomer interaction in propranolol metabolism in rat liver microsomes.
Biochemical pharmacology 1993;46(10):1759-65.
1993: Masubuchi Y; Kagimoto N; Narimatsu S; Fujita S; Suzuki T
Regioselective contribution of the cytochrome P-450 2D subfamily to propranolol metabolism in rat liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(6):1012-6.
1993: Narimatsu S; Kariya S; Isozaki S; Ohmori S; Kitada M; Hosokawa S; Masubuchi Y; Suzuki T
Involvement of CYP2D6 in oxidative metabolism of cinnarizine and flunarizine in human liver microsomes.
Biochemical and biophysical research communications 1993;193(3):1262-8.
1993: Suzuki T; Ishida R; Matsui S; Masubuchi Y; Narimatzu S
Kinetic analysis of mutual metabolic inhibition of lidocaine and propranolol in rat liver microsomes.
Biochemical pharmacology 1993;45(7):1528-30.
1992: Ishida R; Suzuki K; Masubuchi Y; Narimatsu S; Fujita S; Suzuki T
Enzymatic basis for the non-linearity of hepatic elimination of propranolol in the isolated perfused rat liver.
Biochemical pharmacology 1992;44(12):2281-8.
1992: Masubuchi Y; Araki J; Narimatsu S; Suzuki T
Metabolic activation of lidocaine and covalent binding to rat liver microsomal protein.
Biochemical pharmacology 1992;43(12):2551-7.
1992: Ishida R; Obara S; Masubuchi Y; Narimatsu S; Fujita S; Suzuki T
Induction of propranolol metabolism by the azo dye sudan III in rats.
Biochemical pharmacology 1992;43(11):2489-92.
1992: Suzuki T; Narimatsu S; Fujita S; Masubuchi Y; Umeda S; Imaoka S; Funae Y
Purification and characterization of a cytochrome P-450 isozyme catalyzing bunitrolol 4-hydroxylation in liver microsomes of male rats.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(3):367-73.
1992: Masubuchi Y; Suzuki K; Fujita S; Suzuki T
A possible mechanism of the impairment of hepatic microsomal monooxygenase activities after multiple administration of propranolol in rats.
Biochemical pharmacology 1992;43(4):757-62.
1992: Masubuchi Y; Narimatsu S; Suzuki T
Activation of propranolol and irreversible binding to rat liver microsomes: strain differences and effects of inhibitors.
Biochemical pharmacology 1992;43(3):635-7.
1992: Suzuki T; Fujita S; Narimatsu S; Masubuchi Y; Tachibana M; Ohta S; Hirobe M
Cytochrome P450 isozymes catalyzing 4-hydroxylation of parkinsonism-related compound 1,2,3,4-tetrahydroisoquinoline in rat liver microsomes.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(2):771-6.
1991: Suzuki T; Narimatsu S; Fujita S; Masubuchi Y; Umeda S
Impairment of bunitrolol 4-hydroxylase activity in liver microsomes of dark agouti rats.
Biochemical pharmacology 1991;42(11):2241-4.
1991: Masubuchi Y; Umeda S; Chiba M; Fujita S; Suzuki T
Selective 3-hydroxylation deficiency of lidocaine and its metabolite in Dark Agouti rats.
Biochemical pharmacology 1991;42(3):693-5.
1991: Masubuchi Y; Fujita S; Chiba M; Kagimoto N; Umeda S; Suzuki T
Impairment of debrisoquine 4-hydroxylase and related monooxygenase activities in the rat following treatment with propranolol.
Biochemical pharmacology 1991;41(6-7):861-5.
1988: Fujita S; Matsunaga T; Masubuchi Y; Suzuki T
Possible mechanism of Sudan III-induced prevention of chemical carcinogenesis in rats.
Cancer research 1988;48(2):254-9.

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Yasuhiro Masubuchi

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