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Gema Mateo

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Bruno Paiva; Julia Almeida; Martin Pérez-Andrés; Gema Mateo; Antonio López; Ana Rasillo; María-Belén Vídriales; Ma Consuelo López-Berges; Jesús F San Miguel; Alberto Orfao
Utility of flow cytometry immunophenotyping in multiple myeloma and other clonal plasma cell-related disorders.
Ernesto Pérez-Persona; Gema Mateo; Ramón García-Sanz; María-Victoria Mateos; Natalia de Las Heras; Alfonso García de Coca; José M Hernández; Josefina Galende; Guillermo Martín-Nuñez; Abelardo Bárez; José M Alonso; Alejandro Martín; Consuelo López-Berges; Alberto Orfao; Jesús F San Miguel; María-Belén Vidriales
Risk of progression in smouldering myeloma and monoclonal gammopathies of unknown significance: comparative analysis of the evolution of monoclonal component and multiparameter flow cytometry of bone marrow plasma cells.
Bruno Paiva; Maria-Belén Vidriales; Gema Mateo; Jose J Pérez; Maria Angeles Montalbán; Anna Sureda; Laura Montejano; Norma C Gutiérrez; Alfonso García de Coca; Natalia de las Heras; Maria Victoria Mateos; Maria Consuelo López-Berges; Raimundo García-Boyero; Josefina Galende; Jose Hernández; Luis Palomera; Dolores Carrera; Rafael Martínez; Javier de la Rubia; Alejandro Martín; Yolanda González; Joan Bladé; Juan José Lahuerta; Alberto Orfao; Jesús F San Miguel
The persistence of immunophenotypically normal residual bone marrow plasma cells at diagnosis identifies a good prognostic subgroup of symptomatic multiple myeloma patients.

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All Publications

2010: Bruno Paiva; Julia Almeida; Martin Pérez-Andrés; Gema Mateo; Antonio López; Ana Rasillo; María-Belén Vídriales; Ma Consuelo López-Berges; Jesús F San Miguel; Alberto Orfao
Utility of flow cytometry immunophenotyping in multiple myeloma and other clonal plasma cell-related disorders.
Cytometry. Part B, Clinical cytometry 2010;78(4):239-52.
2010: Ernesto Pérez-Persona; Gema Mateo; Ramón García-Sanz; María-Victoria Mateos; Natalia de Las Heras; Alfonso García de Coca; José M Hernández; Josefina Galende; Guillermo Martín-Nuñez; Abelardo Bárez; José M Alonso; Alejandro Martín; Consuelo López-Berges; Alberto Orfao; Jesús F San Miguel; María-Belén Vidriales
Risk of progression in smouldering myeloma and monoclonal gammopathies of unknown significance: comparative analysis of the evolution of monoclonal component and multiparameter flow cytometry of bone marrow plasma cells.
British journal of haematology 2010;148(1):110-4.
2009: Bruno Paiva; Maria-Belén Vidriales; Gema Mateo; Jose J Pérez; Maria Angeles Montalbán; Anna Sureda; Laura Montejano; Norma C Gutiérrez; Alfonso García de Coca; Natalia de las Heras; Maria Victoria Mateos; Maria Consuelo López-Berges; Raimundo García-Boyero; Josefina Galende; Jose Hernández; Luis Palomera; Dolores Carrera; Rafael Martínez; Javier de la Rubia; Alejandro Martín; Yolanda González; Joan Bladé; Juan José Lahuerta; Alberto Orfao; Jesús F San Miguel
The persistence of immunophenotypically normal residual bone marrow plasma cells at diagnosis identifies a good prognostic subgroup of symptomatic multiple myeloma patients.
Blood 2009;114(20):4369-72.
2008: Bruno Paiva; Maria-Belén Vidriales; Jorge Cerveró; Gema Mateo; Jose J Pérez; Maria A Montalbán; Anna Sureda; Laura Montejano; Norma C Gutiérrez; Alfonso García de Coca; Natalia de Las Heras; Maria V Mateos; Maria C López-Berges; Raimundo García-Boyero; Josefina Galende; Jose Hernández; Luis Palomera; Dolores Carrera; Rafael Martínez; Javier de la Rubia; Alejandro Martín; Joan Bladé; Juan J Lahuerta; Alberto Orfao; Jesús F San Miguel
Multiparameter flow cytometric remission is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation.
Blood 2008;112(10):4017-23.
2008: Gema Mateo; M Angeles Montalbán; Maria-Belén Vidriales; Juan J Lahuerta; Maria V Mateos; Norma Gutiérrez; Laura Rosiñol; Laura Montejano; Joan Bladé; Rafael Martínez; Javier de la Rubia; Joaquín Diaz-Mediavilla; Anna Sureda; José M Ribera; José M Ojanguren; Felipe de Arriba; Luis Palomera; María José Terol; Alberto Orfao; Jesús F San Miguel
Prognostic value of immunophenotyping in multiple myeloma: a study by the PETHEMA/GEM cooperative study groups on patients uniformly treated with high-dose therapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(16):2737-44.
2008: María-Victoria Mateos; José M Hernández; Miguel T Hernández; Norma C Gutiérrez; Luis Palomera; Marta Fuertes; Pedro Garcia-Sanchez; Juán J Lahuerta; Javier de la Rubia; María José Terol; Anna Sureda; Joan Bargay; Paz Ribas; Adrian Alegre; Felipe de Arriba; Albert Oriol; Dolores Carrera; José García-Laraña; Ramón García-Sanz; Joan Bladé; Felipe Prósper; Gema Mateo; Dixie Esseltine; Helgi van de Velde; Jesús F San Miguel
Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: updated time-to-events results and prognostic factors for time to progression.
Haematologica 2008;93(4):560-5.
2007: Ernesto Pérez-Persona; María-Belén Vidriales; Gema Mateo; Ramón García-Sanz; Maria V Mateos; Alfonso García de Coca; Josefina Galende; Guillermo Martín-Nuñez; José M Alonso; Natalia de Las Heras; Jesús M Hernández; Alejandro Martín; Consuelo López-Berges; Alberto Orfao; Jesús F San Miguel
New criteria to identify risk of progression in monoclonal gammopathy of uncertain significance and smoldering multiple myeloma based on multiparameter flow cytometry analysis of bone marrow plasma cells.
Blood 2007;110(7):2586-92.
2006: Maria V Mateos; Jesús M Hernández; Miguel-T Hernández; Norma C Gutiérrez; Luis Palomera; Marta Fuertes; Joaquín Díaz-Mediavilla; Juan José Lahuerta; Javier de la Rubia; María José Terol; Anna Sureda; Joan Bargay; Paz Ribas; Felipe de Arriba; Adrián Alegre; Albert Oriol; Dolores Carrera; José García-Laraña; Ramón García-Sanz; Joan Bladé; Felipe Prósper; Gema Mateo; Dixie Esseltine; Helgi van de Velde; Jesús F San Miguel
Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: results of a multicenter phase 1/2 study.
Blood 2006;108(7):2165-72.
2006: Jesús F San Miguel; Norma C Gutiérrez; Gema Mateo; Alberto Orfao
Conventional diagnostics in multiple myeloma.
European journal of cancer (Oxford, England : 1990) 2006;42(11):1510-9.
2006: Patricia Maiso; Xonia Carvajal-Vergara; Enrique M Ocio; Ricardo López-Pérez; Gema Mateo; Norma C Gutiérrez; Peter Atadja; Atanasio Pandiella; Jesús F San Miguel
The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance.
Cancer research 2006;66(11):5781-9.
2006: Martin Pérez-Andres; Julia Almeida; Marta Martin-Ayuso; María Jesús Moro; Guillermo Martin-Nuñez; Josefina Galende; Jose Hernandez; Gema Mateo; Jesús F San Miguel; Alberto Orfao
Characterization of bone marrow T cells in monoclonal gammopathy of undetermined significance, multiple myeloma, and plasma cell leukemia demonstrates increased infiltration by cytotoxic/Th1 T cells demonstrating a squed TCR-Vbeta repertoire.
Cancer 2006;106(6):1296-305.
2005: María Eugenia Sarasquete; Ramón García-Sanz; David González; Joaquín Martínez; Gema Mateo; Pilar Martínez; José Maria Ribera; Jesús M Hernández; Juan José Lahuerta; Alberto Orfão; Marcos González; Jesús F San Miguel
Minimal residual disease monitoring in multiple myeloma: a comparison between allelic-specific oligonucleotide real-time quantitative polymerase chain reaction and flow cytometry.
Haematologica 2005;90(10):1365-72.
2005: Xonia Carvajal-Vergara; Soraya Tabera; Juan Carlos Montero; Azucena Esparís-Ogando; Ricardo López-Pérez; Gema Mateo; Norma C Gutiérrez; Marisa Parmo-Cabañas; Joaquin Teixidó; Jesús F San Miguel; Atanasio Pandiella
Multifunctional role of Erk5 in multiple myeloma.
Blood 2005;105(11):4492-9.
2005: Gema Mateo; Mariana Castellanos; Ana Rasillo; Norma C Gutiérrez; Maria A Montalbán; M Luisa Martín; Jesús Ma Hernández; Ma Consuelo López-Berges; Laura Montejano; Joan Bladé; Maria V Mateos; Anna Sureda; Javier de la Rubia; Joaquín Díaz-Mediavilla; Atanasio Pandiella; Juan José Lahuerta; Alberto Orfao; Jesús F San Miguel
Genetic abnormalities and patterns of antigenic expression in multiple myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(10):3661-7.
2005: Azucena Esparís-Ogando; Adrián Alegre; Beatriz Aguado; Gema Mateo; Norma C Gutiérrez; Joan Bladé; David P Schenkein; Atanasio Pandiella; Jesús F San Miguel
Bortezomib is an efficient agent in plasma cell leukemias.
International journal of cancer. Journal international du cancer 2005;114(4):665-7.
2005: Enrique M Ocio; Gema Mateo; Belen Vidriales; Maria-Consuelo Lopez-Berges; Ramon Garcia-Sanz; Jesus M Hernandez; Alberto Orfao; Jesús F San Miguel
Cell cycle analysis of Waldenstrom's macroglobulinemia.
Clinical lymphoma 2005;5(4):250-2.
2005: Enrique M Ocio; Jesus M Hernandez; Gema Mateo; Maria Luz Sanchez; Belen Gonzalez; Belen Vidriales; Norma C Gutierrez; Alberto Orfao; Jesús F San Miguel
Immunophenotypic and cytogenetic comparison of Waldenstrom's macroglobulinemia with splenic marginal zone lymphoma.
Clinical lymphoma 2005;5(4):241-5.
2005: M Pérez-Andrés; Julia Almeida; Marta Martín-Ayuso; María Jesús Moro; G Martín-Nuñez; Josefina Galende; D Borrego; M J Rodríguez; F Ortega; Jose Hernandez; I Moreno; M Domínguez; Gema Mateo; Jesús F San Miguel; Alberto Orfao
Clonal plasma cells from monoclonal gammopathy of undetermined significance, multiple myeloma and plasma cell leukemia show different expression profiles of molecules involved in the interaction with the immunological bone marrow microenvironment.
Leukemia 2005;19(3):449-55.
2004: Ramón García-Sanz; M I González-Fraile; Gema Mateo; Jesús M Hernández; Ma Consuelo López-Berges; N de las Heras; Javier Fernández-Calvo; F Ortega; Juan A Portero; Abelardo Bárez; Josefina Galende; Alberto Orfão; Jesús F San Miguel
Proliferative activity of plasma cells is the most relevant prognostic factor in elderly multiple myeloma patients.
International journal of cancer. Journal international du cancer 2004;112(5):884-9.
2004: Norma C Gutiérrez; Juan L García; Jesús M Hernández; Eva Lumbreras; Mariana Castellanos; Ana Rasillo; Gema Mateo; Jesús M Hernández; Sonia Pérez; Alberto Orfao; Jesús F San Miguel
Prognostic and biologic significance of chromosomal imbalances assessed by comparative genomic hybridization in multiple myeloma.
Blood 2004;104(9):2661-6.
2004: Jesús M Hernández; Ramón García-Sanz; E Golvano; Joan Bladé; J Fernandez-Calvo; Jesús Trujillo; J A Soler; Santiago Gardella; Félix Carbonell; Gema Mateo; Jesús F San Miguel
Randomized comparison of dexamethasone combined with melphalan versus melphalan with prednisone in the treatment of elderly patients with multiple myeloma.
British journal of haematology 2004;127(2):159-64.
2004: M Pérez-Andrés; M Santiago; J Almeida; Gema Mateo; A Porwit-MacDonald; E Bjorklund; G Valet; Jaco Kraan; Jan W Gratama; Jean-Luc D'Hautcourt; H Merle-Beral; M Lima; M A Montalban; Jesús F San Miguel; I Orfao
Immunophenotypic approach to the identification and characterization of clonal plasma cells from patients with monoclonal gammopathies.
Journal of biological regulators and homeostatic agents 2004;18(3-4):392-8.
2003: Atanasio Pandiella; Xonia Carvajal-Vergara; Soraya Tabera; Gema Mateo; Norma C Gutiérrez; Jesús F San Miguel
Imatinib mesylate (STI571) inhibits multiple myeloma cell proliferation and potentiates the effect of common antimyeloma agents.
British journal of haematology 2003;123(5):858-68.
2003: Gema Mateo; Mercedes Corral; Julia Almeida; Consuelo López-Berges; maría Jesús Nieto; Antonia García-Marcos; Lourdes Vázquez; Consuelo del Cañizo; Alberto Orfao; Jesús F San Miguel
Immunophenotypic analysis of peripheral blood stem cell harvests from patients with multiple myeloma.
Haematologica 2003;88(9):1013-21.
2003: Jesús F San Miguel; María-Belén Vidriales; Enrique M Ocio; Gema Mateo; F Sánchez-Guijo; María Luz Sánchez; Luis Escribano; Abelardo Bárez; María Jesús Moro; José Hernández; C Aguilera; R Cuello; J García-Frade; R López; Juan A Portero; Alberto Orfao
Immunophenotypic analysis of Waldenstrom's macroglobulinemia.
Seminars in oncology 2003;30(2):187-95.
2002: Alejandro Martín; Ramón García-Sanz; José Hernández; Joan Bladé; Begoña Suquía; Javier Fernández-Calvo; Marcos González; Gema Mateo; Alberto Orfao; Jesús F San Miguel
Pamidronate induces bone formation in patients with smouldering or indolent myeloma, with no significant anti-tumour effect.
British journal of haematology 2002;118(1):239-42.
2002: Jesús F San Miguel; Julia Almeida; Gema Mateo; Joan Bladé; Consuelo López-Berges; Dolores Caballero; José Hernández; María Jesús Moro; Javier Fernández-Calvo; Joaquín Díaz-Mediavilla; Luis Palomera; Alberto Orfao
Immunophenotypic evaluation of the plasma cell compartment in multiple myeloma: a tool for comparing the efficacy of different treatment strategies and predicting outcome.
Blood 2002;99(5):1853-6.
2001: María Dolores Tabernero; Aglae Bortoluci; I Alaejos; Ma Consuelo López-Berges; Ana Rasillo; Ramón García-Sanz; M García; José María Sayagués; Marcos González; Gema Mateo; Jesús F San Miguel; Alberto Orfao
Adult precursor B-ALL with BCR/ABL gene rearrangements displays a unique immunophenotype based on the pattern of CD10, CD34, CD13 and CD38 expresssion.
Leukemia 2001;15(3):406-14.
2000: Norma C Gutiérrez; Jesús M Hernández; Juan L García; Julia Almeida; Gema Mateo; MI González; José Hernández; Javier Fernández-Calvo; Jesús F San Miguel
Correlation between cytogenetic abnormalities and disease characteristics in multiple myeloma: monosomy of chromosome 13 and structural abnormalities of 11q are associated with a high percentage of S-phase plasma cells.
Haematologica 2000;85(11):1146-52.
2000: Ricardo López-Pérez; Ramón García-Sanz; David González; Ana Balanzategui; M Carmen Chillón; I Alaejos; Maria V Mateos; María Dolores Caballero; Gema Mateo; Maria J Nieto; Marcos González; Jesús F San Miguel
The detection of contaminating clonal cells in apheresis products is related to response and outcome in multiple myeloma undergoing autologous peripheral blood stem cell transplantation.
Leukemia 2000;14(8):1493-9.
1999: Julia Almeida; Alberto Orfao; M Ocqueteau; Gema Mateo; Mercedes Corral; María Dolores Caballero; J Blade; María Jesús Moro; Jose Hernandez; Jesús F San Miguel
High-sensitive immunophenotyping and DNA ploidy studies for the investigation of minimal residual disease in multiple myeloma.
British journal of haematology 1999;107(1):121-31.
1999: Julia Almeida; Alberto Orfao; Gema Mateo; M Ocqueteau; Ramón García-Sanz; María Jesús Moro; Jose Hernandez; F Ortega; D Borrego; Abelardo Barez; M Mejido; Jesús F San Miguel
Immunophenotypic and DNA content characteristics of plasma cells in multiple myeloma and monoclonal gammopathy of undetermined significance.
Pathologie-biologie 1999;47(2):119-27.
1998: J M Hernández; Norma C Gutiérrez; J Almeida; J L García; M A Sánchez; Gema Mateo; A Ríos; Jesús F San Miguel
IL-4 improves the detection of cytogenetic abnormalities in multiple myeloma and increases the proportion of clonally abnormal metaphases.
British journal of haematology 1998;103(1):163-7.