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Larry Matherly

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Christina Cherian; Aleem Gangjee; Zhanjun Hou; Sita Kugel Desmoulin; Juiwanna Kushner; Lisa Anne Polin ; Mark Stout; Lei Wang; Kathryn White; Larry H Matherly
Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter.
Chengzhi Xie; Steven A Buck; Holly Edwards; Salvatore B Lograsso; Larry H Matherly; Jeffrey W Taub; Yubin Ge
Valproic acid synergistically enhances the cytotoxicity of clofarabine in pediatric acute myeloid leukemia cells.
Sita Kugel Desmoulin; Aleem Gangjee; Zhanjun Hou; Larry H Matherly
The human proton-coupled folate transporter: Biology and therapeutic applications to cancer.

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2013: Christina Cherian; Aleem Gangjee; Zhanjun Hou; Sita Kugel Desmoulin; Juiwanna Kushner; Lisa Anne Polin ; Mark Stout; Lei Wang; Kathryn White; Larry H Matherly
Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter.
Cancer chemotherapy and pharmacology 2013;71(4):999-1011.
2012: Chengzhi Xie; Steven A Buck; Holly Edwards; Salvatore B Lograsso; Larry H Matherly; Jeffrey W Taub; Yubin Ge
Valproic acid synergistically enhances the cytotoxicity of clofarabine in pediatric acute myeloid leukemia cells.
Pediatric blood & cancer 2012;59(7):1245-51.
2012: Sita Kugel Desmoulin; Aleem Gangjee; Zhanjun Hou; Larry H Matherly
The human proton-coupled folate transporter: Biology and therapeutic applications to cancer.
Cancer biology & therapy 2012;13(14):1355-73.
2012: Sita Kugel Desmoulin; Aleem Gangjee; Zhanjun Hou; Juiwanna Kushner; Lisa Anne Polin ; Mark Stout; Lei Wang; Kathryn White; Christina Cherian; Larry H Matherly
Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter.
Molecular pharmacology 2012;82(4):591-600.
2012: Alan Menter; Joel R Morgan; Aaron D Schuler; Breck Thrash; Lei Wang; Christina Cherian; Aleem Gangjee; Stuart J Kahn; Dean Y Maeda; Larry H Matherly; John A Zebala
Intestinal transport of aminopterin enantiomers in dogs and humans with psoriasis is stereoselective: evidence for a mechanism involving the proton-coupled folate transporter.
The Journal of pharmacology and experimental therapeutics 2012;342(3):696-708.
2012: Jianmei Wu; Patricia M LoRusso; Larry H Matherly; Jing Li
Implications of plasma protein binding for pharmacokinetics and pharmacodynamics of the γ-secretase inhibitor RO4929097.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(7):2066-79.
2012: Lei Wang; Christina Cherian; Zhanjun Hou; Sita Kugel Desmoulin; Larry H Matherly; Shermaine Mitchell-Ryan; Aleem Gangjee
Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier.
Journal of medicinal chemistry 2012;55(4):1758-70.
2012: Zhanjun Hou; Benjamin Hsiung; Sita Kugel Desmoulin; Christina Cherian; Erika Etnyre; Kamiar Moin; Mary Olive; Patrick A Wloszczynski; Larry H Matherly
Identification and functional impact of homo-oligomers of the human proton-coupled folate transporter.
The Journal of biological chemistry 2012;287(7):4982-95.
2011: Sita Kugel Desmoulin; Juiwanna Kushner; Christina Cherian; Aleem Gangjee; Eric Hales; Zhanjun Hou; Lisa Anne Polin ; Mark Stout; Lei Wang; Kathryn White; Larry H Matherly
Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter.
Molecular pharmacology 2011;80(6):1096-107.
2011: Lei Wang; Kathryn White; Min-Hwang Chang; Christina Cherian; Sita Kugel Desmoulin; Andreas Fulterer; Zhanjun Hou; Juiwanna Kushner; Larry H Matherly; Shermaine Mitchell-Ryan; Lisa Anne Polin ; Michael F Romero; Mark Stout; Aleem Gangjee
Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase.
Journal of medicinal chemistry 2011;54(20):7150-64.
2011: Ana C Xavier; Chengzhi Xie; Tugce B Balci; Jason N Berman; Steven A Buck; Graham Dellaire; Alan Anthony Dombkowski; Holly Edwards; Yubin Ge; Larry H Matherly; Jeffrey W Taub
A unique role of GATA1s in Down syndrome acute megakaryocytic leukemia biology and therapy.
PloS one 2011;6(11):e27486.
2010: Shirish M Gadgeel; Michele Cote; Ann Grossbart Schwartz; Larry H Matherly; Antoinette J Wozniak; Gerold Bepler
Parameters for individualizing systemic therapy in non-small cell lung cancer.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2010;13(6):196-204.
2010: Chengzhi Xie; Holly Edwards; Xuelian Xu; Hui Zhou; Steven A Buck; Mark L Stout; Qun Yu; Jeffrey E Rubnitz; Larry H Matherly; Jeffrey W Taub; Yubin Ge
Mechanisms of synergistic antileukemic interactions between valproic acid and cytarabine in pediatric acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(22):5499-510.
2010: Sita Kugel Desmoulin; Yiqiang Wang; Jianmei Wu; Mark Stout; Zhanjun Hou; Andreas Fulterer; Min-Hwang Chang; Michael F Romero; Christina Cherian; Aleem Gangjee; Larry H Matherly
Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors.
Molecular pharmacology 2010;78(4):577-87.
2010: Zhanjun Hou; Jianmei Wu; Jun Ye; Christina Cherian; Larry H Matherly
Substrate-specific binding and conformational changes involving Ser313 and transmembrane domain 8 of the human reduced folate carrier, as determined by site-directed mutagenesis and protein cross-linking.
The Biochemical journal 2010;430(2):265-74.
2010: Zhanjun Hou; Christina Cherian; Joseph Drews; Jianmei Wu; Larry H Matherly
Identification of the minimal functional unit of the homo-oligomeric human reduced folate carrier.
The Journal of biological chemistry 2010;285(7):4732-40.
2010: Lei Wang; Christina Cherian; Sita Kugel Desmoulin; Lisa Anne Polin ; Yijun Deng; Jianmei Wu; Zhanjun Hou; Kathryn White; Juiwanna Kushner; Larry H Matherly; Aleem Gangjee
Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry.
Journal of medicinal chemistry 2010;53(3):1306-18.
2010: Hind Medyouf; Xiuhua Gao; Florence Armstrong; Samuel Gusscott; Qing Liu; Amanda Larson Gedman; Larry H Matherly; Kirk R Schultz; Francoise Pflumio; Mingjian James You; Andrew P Weng
Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.
Blood 2010;115(6):1175-84.
2009: Ikuko Kato; Kawsar Z Badsha; Susan J Land; Jordan M Nechvatal; Larry H Matherly; Adi L Tarca; Adhip N Majumdar; Marc D Basson; Jeffrey L Ram
DNA/RNA markers for colorectal cancer risk in preserved stool specimens: a pilot study.
Tumori 2009;95(6):753-61.
2009: Holly Edwards; Chengzhi Xie; Katherine M LaFiura; Alan Anthony Dombkowski; Steven Buck; Julie Boerner ; Jeffrey W Taub; Larry H Matherly; Yubin Ge
RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia.
Blood 2009;114(13):2744-52.
2009: Diane C Cabelof; Hiral V Patel; Qing Chen; Holly Van Remmen; Larry H Matherly; Yubin Ge; Jeffrey W Taub
Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome.
Blood 2009;114(13):2753-63.
2009: A Larson Gedman; Q Chen; S Kugel Desmoulin; Yubin Ge; Katherine M LaFiura; Christina L Haska; C Cherian; Meenakshi Devidas; Stephen B Linda; Jeffrey W Taub; Larry H Matherly
The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group.
Leukemia 2009;23(8):1417-25.
2009: Yijun Deng; Xilin Zhou; Sita Kugel Desmoulin; Jianmei Wu; Christina Cherian; Zhanjun Hou; Larry H Matherly; Aleem Gangjee
Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transporter for cellular entry.
Journal of medicinal chemistry 2009;52(9):2940-51.
2009: Zhanjun Hou; Larry H Matherly
Oligomeric structure of the human reduced folate carrier: identification of homo-oligomers and dominant-negative effects on carrier expression and function.
The Journal of biological chemistry 2009;284(5):3285-93.
2009: Rongbao Zhao; Larry H Matherly; I David Goldman
Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues.
Expert reviews in molecular medicine 2009;11():e4.
2008: Yijun Deng; Yiqiang Wang; Christina Cherian; Zhanjun Hou; Steven A Buck; Larry H Matherly; Aleem Gangjee
Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity.
Journal of medicinal chemistry 2008;51(16):5052-63.
2008: Katherine M LaFiura; H Edwards; Jeffrey W Taub; Larry H Matherly; Joseph A Fontana; Anwar N Mohamed; Yaddanapudi Ravindranath; Yubin Ge
Identification and characterization of novel AML1-ETO fusion transcripts in pediatric t(8;21) acute myeloid leukemia: a report from the Children's Oncology Group.
Oncogene 2008;27(36):4933-42.
2008: Yijun Deng; Zhanjun Hou; Lei Wang; Christina Cherian; Jianmei Wu; Aleem Gangjee; Larry H Matherly
Role of lysine 411 in substrate carboxyl group binding to the human reduced folate carrier, as determined by site-directed mutagenesis and affinity inhibition.
Molecular pharmacology 2008;73(4):1274-81.
2008: Yubin Ge; Katherine M LaFiura; Alan Anthony Dombkowski; Q Chen; Scott G Payton; Steven Buck; S Salagrama; A E Diakiw; Larry H Matherly; Jeffrey W Taub
The role of the proto-oncogene ETS2 in acute megakaryocytic leukemia biology and therapy.
Leukemia 2008;22(3):521-9.
2008: Jordan M Nechvatal; Jeffrey L Ram; Marc D Basson; Phanramphoei Namprachan; Stephanie R Niec; Kawsar Z Badsha; Larry H Matherly; Adhip N Majumdar; Ikuko Kato
Fecal collection, ambient preservation, and DNA extraction for PCR amplification of bacterial and human markers from human feces.
Journal of microbiological methods 2008;72(2):124-32.
2008: David Patterson; Christine Graham; Christina Cherian; Larry H Matherly
A humanized mouse model for the reduced folate carrier.
Molecular genetics and metabolism 2008;93(2):95-103.
2008: Larry H Matherly; Zhanjun Hou
Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter.
Vitamins and hormones 2008;79():145-84.
2007: Lawrence H Lash; David A Putt; Feng Xu; Larry H Matherly
Role of rat organic anion transporter 3 (Oat3) in the renal basolateral transport of glutathione.
Chemico-biological interactions 2007;170(2):124-34.
2007: Andong Qiu; Sang Hee Min; Michaela Jansen; Usha Malhotra; Eugenia Tsai; Diane C Cabelof; Larry H Matherly; Rongbao Zhao; Myles H Akabas; I David Goldman
Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction.
American journal of physiology. Cell physiology 2007;293(5):C1669-78.
2007: Katherine M LaFiura; Dawn Bielawski; Norberto C Posecion; Enrique M Ostrea; Larry H Matherly; Jeffrey W Taub; Yubin Ge
Association between prenatal pesticide exposures and the generation of leukemia-associated T(8;21).
Pediatric blood & cancer 2007;49(5):624-8.
2007: Larry H Matherly; Zhanjun Hou; Yijun Deng
Human reduced folate carrier: translation of basic biology to cancer etiology and therapy.
Cancer metastasis reviews 2007;26(1):111-28.
2007: Scott G Payton; Christina L Haska; Robin M Flatley; Yubin Ge; Larry H Matherly
Effects of 5' untranslated region diversity on the posttranscriptional regulation of the human reduced folate carrier.
Biochimica et biophysica acta 2007;1769(2):131-8.
2007: Yubin Ge; Christina L Haska; Katherine M LaFiura; Meenakshi Devidas; Stephen B Linda; Mingjun Liu; Ron L Thomas; Jeffrey W Taub; Larry H Matherly
Prognostic role of the reduced folate carrier, the major membrane transporter for methotrexate, in childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(2 Pt 1):451-7.
2006: Zhanjun Hou; Jun Ye; Christina L Haska; Larry H Matherly
Transmembrane domains 4, 5, 7, 8, and 10 of the human reduced folate carrier are important structural or functional components of the transmembrane channel for folate substrates.
The Journal of biological chemistry 2006;281(44):33588-96.
2006: Diane C Cabelof; Yuji Ikeno; Abraham Nyska; Rita A Busuttil; Njwen Anyangwe; Jan Vijg; Larry H Matherly; James Tucker; Samuel H Wilson; Arlan G Richardson; Ahmad R Heydari
Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate.
Cancer research 2006;66(15):7460-5.
2006: Diane C Cabelof; Julian J Raffoul; Yubin Ge; Holly Van Remmen; Larry H Matherly; Ahmad R Heydari
Age-related loss of the DNA repair response following exposure to oxidative stress.
The journals of gerontology. Series A, Biological sciences and medical sciences 2006;61(5):427-34.
2006: Sezen Gurdag; Jayant J Khandare; Sarah E Stapels; Larry H Matherly; Rangaramanujam M Kannan
Activity of dendrimer-methotrexate conjugates on methotrexate-sensitive and -resistant cell lines.
Bioconjugate chemistry 2006;17(2):275-83.
2006: Li V Yang; Junmei Wan; Yubin Ge; Z Fu; S Y Kim; Y Fujiwara; Jeffrey W Taub; Larry H Matherly; James F Eliason; Li Li
The GATA site-dependent hemogen promoter is transcriptionally regulated by GATA1 in hematopoietic and leukemia cells.
Leukemia 2006;20(3):417-25.
2006: Feng Xu; David A Putt; Larry H Matherly; Lawrence H Lash
Modulation of expression of rat mitochondrial 2-oxoglutarate carrier in NRK-52E cells alters mitochondrial transport and accumulation of glutathione and susceptibility to chemically induced apoptosis.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1175-86.
2006: Yubin Ge; Alan Anthony Dombkowski; Katherine M LaFiura; Dana A Tatman; Ravikiran S Yedidi; Mark L Stout; Steven Buck; Gita V Massey; David L Becton; Howard J Weinstein; Yaddanapudi Ravindranath; Larry H Matherly; Jeffrey W Taub
Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia.
Blood 2006;107(4):1570-81.
2006: Mingjun Liu; Yubin Ge; Scott G Payton; Amro Aboukameel; Stephen Buck; Robin M Flatley; Christina L Haska; Ramzi M Mohammad; Jeffrey W Taub; Larry H Matherly
Transcriptional regulation of the human reduced folate carrier in childhood acute lymphoblastic leukemia cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(2):608-16.
2005: Scott G Payton; Mingjun Liu; Yubin Ge; Larry H Matherly
Transcriptional regulation of the human reduced folate carrier A1/A2 promoter: Identification of critical roles for the USF and GATA families of transcription factors.
Biochimica et biophysica acta 2005;1731(2):115-24.
2005: Zhanjun Hou; Sarah E Stapels; Christina L Haska; Larry H Matherly
Localization of a substrate binding domain of the human reduced folate carrier to transmembrane domain 11 by radioaffinity labeling and cysteine-substituted accessibility methods.
The Journal of biological chemistry 2005;280(43):36206-13.
2005: Yubin Ge; Tanya L Jensen; Dana A Tatman; Mark L Stout; Steven Buck; Yaddanapudi Ravindranath; Larry H Matherly; Jeffrey W Taub
Role of USF1 in the differential expression of the human deoxycytidine kinase gene in acute myeloid leukemia.
Leukemia 2005;19(4):677-9.
2005: Mingjun Liu; Yubin Ge; Diane C Cabelof; Amro Aboukameel; Ahmad R Heydari; Ramzi M Mohammad; Larry H Matherly
Structure and regulation of the murine reduced folate carrier gene: identification of four noncoding exons and promoters and regulation by dietary folates.
The Journal of biological chemistry 2005;280(7):5588-97.
2005: Yubin Ge; Mark L Stout; Dana A Tatman; Tanya L Jensen; Steven Buck; Ron L Thomas; Yaddanapudi Ravindranath; Larry H Matherly; Jeffrey W Taub
GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia.
Journal of the National Cancer Institute 2005;97(3):226-31.
2005: Scott G Payton; Johnathan R Whetstine; Yubin Ge; Larry H Matherly
Transcriptional regulation of the human reduced folate carrier promoter C: synergistic transactivation by Sp1 and C/EBP beta and identification of a downstream repressor.
Biochimica et biophysica acta 2005;1727(1):45-57.
2004: Teah L Witt; Sarah E Stapels; Larry H Matherly
Restoration of transport activity by co-expression of human reduced folate carrier half-molecules in transport-impaired K562 cells: localization of a substrate binding domain to transmembrane domains 7-12.
The Journal of biological chemistry 2004;279(45):46755-63.
2004: Mingjun Liu; Johnathan R Whetstine; Scott G Payton; Yubin Ge; Robin M Flatley; Larry H Matherly
Roles of USF, Ikaros and Sp proteins in the transcriptional regulation of the human reduced folate carrier B promoter.
The Biochemical journal 2004;383(Pt 2):249-57.
2004: Jeffrey W Taub; Gina Mundschau; Yubin Ge; Janet Poulik; Faisal Qureshi; Tanya Jensen; S Jill James; Larry H Matherly; Joshua Wechsler; John D Crispino
Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome.
Blood 2004;104(5):1588-9.
2004: Robin M Flatley; Scott G Payton; Jeffrey W Taub; Larry H Matherly
Primary acute lymphoblastic leukemia cells use a novel promoter and 5'noncoding exon for the human reduced folate carrier that encodes a modified carrier translated from an upstream translational start.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(15):5111-22.
2004: Yotam Kaufman; Stavit Drori; Peter Cole; Barton A. Kamen; Jenny Sirota; Ilan Ifergan; Myriam Weyl Ben Arush; Ronit Elhasid; Dvora Sahar; G J L Kaspers; Gerrit Jansen; Larry H Matherly; Gideon Rechavi; Amos Toren; Yehuda G Assaraf
Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia.
Cancer 2004;100(4):773-82.
2004: Wei Cao; Larry H Matherly
Analysis of the membrane topology for transmembrane domains 7-12 of the human reduced folate carrier by scanning cysteine accessibility methods.
The Biochemical journal 2004;378(Pt 1):201-6.
2004: Yubin Ge; Tanya L Jensen; Mark L Stout; Robin M Flatley; Patrick J Grohar; Yaddanapudi Ravindranath; Larry H Matherly; Jeffrey W Taub
The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines.
Cancer research 2004;64(2):728-35.
2003: Yubin Ge; Tanya L Jensen; Larry H Matherly; Jeffrey W Taub
Physical and functional interactions between USF and Sp1 proteins regulate human deoxycytidine kinase promoter activity.
The Journal of biological chemistry 2003;278(50):49901-10.
2003: Maoxiang Li; Jun-Ying Zhou; Yubin Ge; Larry H Matherly; Gen Sheng Wu
The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation.
The Journal of biological chemistry 2003;278(42):41059-68.
2003: Wei Cao; Larry H Matherly
Characterization of a cysteine-less human reduced folate carrier: localization of a substrate-binding domain by cysteine-scanning mutagenesis and cysteine accessibility methods.
The Biochemical journal 2003;374(Pt 1):27-36.
2003: Yubin Ge; Tanya L Jensen; Larry H Matherly; Jeffrey W Taub
Transcriptional regulation of the cystathionine-beta -synthase gene in Down syndrome and non-Down syndrome megakaryocytic leukemia cell lines.
Blood 2003;101(4):1551-7.
2003: Gert Lubec; M Bajo; Myeong Sook Cheon; H Bajova; Larry H Matherly
Increased expression of human reduced folate carrier in fetal Down syndrome brain.
Journal of neural transmission. Supplementum 2003;(67):95-103.
2003: Larry H Matherly; I David Goldman
Membrane transport of folates.
Vitamins and hormones 2003;66():403-56.
2003: Xiang Y Liu; Teah L Witt; Larry H Matherly
Restoration of high-level transport activity by human reduced folate carrier/ThTr1 thiamine transporter chimaeras: role of the transmembrane domain 6/7 linker region in reduced folate carrier function.
The Biochemical journal 2003;369(Pt 1):31-7.
2002: Teah L Witt; Larry H Matherly
Identification of lysine-411 in the human reduced folate carrier as an important determinant of substrate selectivity and carrier function by systematic site-directed mutagenesis.
Biochimica et biophysica acta 2002;1567(1-2):56-62.
2002: Yubin Ge; Tanya L Jensen; Larry H Matherly; Jeffrey W Taub
Synergistic regulation of human cystathionine-beta-synthase-1b promoter by transcription factors NF-YA isoforms and Sp1.
Biochimica et biophysica acta 2002;1579(2-3):73-80.
2002: A J Gifford; Michelle Haber; Teah L Witt; Johnathan R Whetstine; Jeffrey W Taub; Larry H Matherly; Murray D Norris
Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells.
Leukemia 2002;16(12):2379-87.
2002: Johnathan R Whetstine; Teah L Witt; Larry H Matherly
The human reduced folate carrier gene is regulated by the AP2 and sp1 transcription factor families and a functional 61-base pair polymorphism.
The Journal of biological chemistry 2002;277(46):43873-80.
2002: Yubin Ge; T Jensen; S Jill James; David L Becton; Gita V Massey; Howard J Weinstein; Yaddanapudi Ravindranath; Larry H Matherly; Jeffrey W Taub
High frequency of the 844ins68 cystathionine-beta-synthase gene variant in Down syndrome children with acute myeloid leukemia.
Leukemia 2002;16(11):2339-41.
2002: Lawrence H Lash; David A Putt; Larry H Matherly
Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter.
The Journal of pharmacology and experimental therapeutics 2002;303(2):476-86.
2002: Johnathan R Whetstine; Robin M Flatley; Larry H Matherly
The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter.
The Biochemical journal 2002;367(Pt 3):629-40.
2002: Masashi Adachi; Janardhan Sampath; Lu-Bin Lan; Daxi Sun; Philip Hargrove; Robin M Flatley; Ann Tatum; Mary Z Edwards; Michele Wezeman; Larry H Matherly; Richard Drake; John D Schuetz
Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing.
The Journal of biological chemistry 2002;277(41):38998-9004.
2002: Xiang Y Liu; Larry H Matherly
Analysis of membrane topology of the human reduced folate carrier protein by hemagglutinin epitope insertion and scanning glycosylation insertion mutagenesis.
Biochimica et biophysica acta 2002;1564(2):333-42.
2002: Jeffrey W Taub; Mark A Konrad; Yubin Ge; John M Naber; Jackie S Scott; Larry H Matherly; Yaddanapudi Ravindranath
High frequency of leukemic clones in newborn screening blood samples of children with B-precursor acute lymphoblastic leukemia.
Blood 2002;99(8):2992-6.
2002: Jeffrey W Taub; Larry H Matherly; Yaddanapudi Ravindranath; G J L Kaspers; M G Rots; C H Zantwijk
Polymorphisms in methylenetetrahydrofolate reductase and methotrexate sensitivity in childhood acute lymphoblastic leukemia.
Leukemia 2002;16(4):764-5.
2002: Janardhan Sampath; Masashi Adachi; Sigrid Hatse; Lieve Naesens; J Balzarini; Robin M Flatley; Larry H Matherly; John D Schuetz
Role of MRP4 and MRP5 in biology and chemotherapy.
AAPS pharmSci 2002;4(3):E14.
2001: Yubin Ge; Larry H Matherly; Jeffrey W Taub
Transcriptional regulation of cell-specific expression of the human cystathionine beta -synthase gene by differential binding of Sp1/Sp3 to the -1b promoter.
The Journal of biological chemistry 2001;276(47):43570-9.
2001: Johnathan R Whetstine; A J Gifford; Teah L Witt; Xiang Y Liu; Robin M Flatley; M Norris; Michelle Haber; Jeffrey W Taub; Yaddanapudi Ravindranath; Larry H Matherly
Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G/A variant at position 80 and transport properties of the His(27) and Arg(27) carriers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(11):3416-22.
2001: Xiang Y Liu; Larry H Matherly
Functional interactions between arginine-133 and aspartate-88 in the human reduced folate carrier: evidence for a charge-pair association.
The Biochemical journal 2001;358(Pt 2):511-6.
2001: Yubin Ge; M A Konrad; Larry H Matherly; Jeffrey W Taub
Transcriptional regulation of the human cystathionine beta-synthase -1b basal promoter: synergistic transactivation by transcription factors NF-Y and Sp1/Sp3.
The Biochemical journal 2001;357(Pt 1):97-105.
2001: S J Shah; Jeffrey W Taub; Teah L Witt; Bradley Pollock; BC Ding; D S Moore; Michael D Amylon; Jeanette Pullen; Yaddanapudi Ravindranath; Larry H Matherly
Relationship of p15 and p16 gene alterations to elevated dihydrofolate reductase in childhood acute lymphoblastic leukaemia.
British journal of haematology 2001;113(3):746-56.
2001: BC Ding; Johnathan R Whetstine; Teah L Witt; J D Schuetz; Larry H Matherly
Repression of human reduced folate carrier gene expression by wild type p53.
The Journal of biological chemistry 2001;276(12):8713-9.
2001: BC Ding; Teah L Witt; Bharati Hukku; Hong-Qiang Heng; long zhang; Larry H Matherly
Association of deletions and translocation of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia cells.
Biochemical pharmacology 2001;61(6):665-75.
2001: Johnathan R Whetstine; Larry H Matherly
The basal promoters for the human reduced folate carrier gene are regulated by a GC-box and a cAMP-response element/AP-1-like element. Basis for tissue-specific gene expression.
The Journal of biological chemistry 2001;276(9):6350-8.
2001: Larry H Matherly
Molecular and cellular biology of the human reduced folate carrier.
Progress in nucleic acid research and molecular biology 2001;67():131-62.
2000: Hamid M Said; Nabendu Chatterjee; R U Haq; Veedamali S Subramanian; Alvaro Ortiz; Larry H Matherly; F M Sirotnak; C Halsted; Stanley A Rubin
Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency.
American journal of physiology. Cell physiology 2000;279(6):C1889-95.
2000: Jeffrey W Taub; Xi Huang; Yubin Ge; JA Dutcher; Mark L Stout; Ramzi M Mohammad; Yaddanapudi Ravindranath; Larry H Matherly
Cystathionine-beta-synthase cDNA transfection alters the sensitivity and metabolism of 1-beta-D-arabinofuranosylcytosine in CCRF-CEM leukemia cells in vitro and in vivo: a model of leukemia in Down syndrome.
Cancer research 2000;60(22):6421-6.
1999: Larry H Matherly; Jeffrey W Taub
Molecular and cellular correlates of methotrexate response in childhood acute lymphoblastic leukemia.
Leukemia & lymphoma 1999;35(1-2):1-20.
1999: Jeffrey W Taub; Xi Huang; Larry H Matherly; Mark L Stout; Steven Buck; Gita V Massey; David L Becton; Myron N Chang; Howard J Weinstein; Yaddanapudi Ravindranath
Expression of chromosome 21-localized genes in acute myeloid leukemia: differences between Down syndrome and non-Down syndrome blast cells and relationship to in vitro sensitivity to cytosine arabinoside and daunorubicin.
Blood 1999;94(4):1393-400.
1999: SC Wong; long zhang; Teah L Witt; SA Proefke; A Bhushan; Larry H Matherly
Impaired membrane transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier.
The Journal of biological chemistry 1999;274(15):10388-94.
1998: long zhang; SC Wong; Larry H Matherly
Structure and organization of the human reduced folate carrier gene.
Biochimica et biophysica acta 1998;1442(2-3):389-93.
1998: SC Wong; long zhang; SA Proefke; Larry H Matherly
Effects of the loss of capacity for N-glycosylation on the transport activity and cellular localization of the human reduced folate carrier.
Biochimica et biophysica acta 1998;1375(1-2):6-12.
1998: A J Gifford; Maria Kavallaris; Janice Madafiglio; Larry H Matherly; BW Stewart; Michelle Haber; Murray D Norris
P-glycoprotein-mediated methotrexate resistance in CCRF-CEM sublines deficient in methotrexate accumulation due to a point mutation in the reduced folate carrier gene.
International journal of cancer. Journal international du cancer 1998;78(2):176-81.
1998: long zhang; Jeffrey W Taub; M Williamson; SC Wong; Bharati Hukku; Jeanette Pullen; Yaddanapudi Ravindranath; Larry H Matherly
Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: relationship to immunophenotype and ploidy.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(9):2169-77.
1998: long zhang; S C Wong; Larry H Matherly
Transcript heterogeneity of the human reduced folate carrier results from the use of multiple promoters and variable splicing of alternative upstream exons.
The Biochemical journal 1998;332 ( Pt 3)():773-80.
1998: SC Wong; long zhang; SA Proefke; Bharati Hukku; Larry H Matherly
Gene amplification and increased expression of the reduced folate carrier in transport elevated K562 cells.
Biochemical pharmacology 1998;55(7):1135-8.
1997: Larry H Matherly; Jeffrey W Taub; S C Wong; P M Simpson; R Ekizian; Steven Buck; M Williamson; Michael D Amylon; Jeanette Pullen; Bruce M Camitta; Yaddanapudi Ravindranath
Increased frequency of expression of elevated dihydrofolate reductase in T-cell versus B-precursor acute lymphoblastic leukemia in children.
Blood 1997;90(2):578-89.
1997: SC Wong; R McQuade; SA Proefke; A Bhushan; Larry H Matherly
Human K562 transfectants expressing high levels of reduced folate carrier but exhibiting low transport activity.
Biochemical pharmacology 1997;53(2):199-206.
1997: Jacques Jolivet; M P Faure; S C Wong; Jeffrey W Taub; Larry H Matherly
Confocal microscopy visualization of antifolate uptake by the reduced folate carrier in human leukaemic cells.
British journal of cancer 1997;76(6):734-8.
1996: Larry H Matherly; Jeffrey W Taub
Methotrexate pharmacology and resistance in childhood acute lymphoblastic leukemia.
Leukemia & lymphoma 1996;21(5-6):359-68.
1996: Jeffrey W Taub; Larry H Matherly; Mark L Stout; Steven Buck; James G Gurney; Yaddanapudi Ravindranath
Enhanced metabolism of 1-beta-D-arabinofuranosylcytosine in Down syndrome cells: a contributing factor to the superior event free survival of Down syndrome children with acute myeloid leukemia.
Blood 1996;87(8):3395-403.
1996: B E Miller; Larry H Matherly; M Lehotan; Gloria H Heppner
Rates of development of methotrexate resistance in heterogeneous mouse mammary tumor cell cultures.
Journal of experimental therapeutics & oncology 1996;1(1):30-8.
1995: SC Wong; SA Proefke; A Bhushan; Larry H Matherly
Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells.
The Journal of biological chemistry 1995;270(29):17468-75.
1995: Larry H Matherly; Jeffrey W Taub; Yaddanapudi Ravindranath; SA Proefke; SC Wong; P Gimotty; S Buck; J E Wright; Andre Rosowsky
Elevated dihydrofolate reductase and impaired methotrexate transport as elements in methotrexate resistance in childhood acute lymphoblastic leukemia.
Blood 1995;85(2):500-9.
1994: Andre Rosowsky; H Bader; J E Wright; Khandan Keyomarsi; Larry H Matherly
Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin.
Journal of medicinal chemistry 1994;37(14):2167-74.
1994: Larry H Matherly; S M Angeles
Role of N-glycosylation in the structure and function of the methotrexate membrane transporter from CCRF-CEM human lymphoblastic leukemia cells.
Biochemical pharmacology 1994;47(6):1094-8.
1993: Larry H Matherly; S M Angeles; J J McGuire
Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired antifolate membrane transport.
Biochemical pharmacology 1993;46(12):2185-95.
1993: Larry H Matherly; S M Angeles
Determinants of the disparate antitumor effects of (6R)5,10-dideaza-5,6,7,8- tetrahydrofolate and methotrexate toward methotrexate resistant CCRF-CEM cells, characterized by severely impaired antifolate membrane transport.
Advances in experimental medicine and biology 1993;338():783-6.
1992: Larry H Matherly; S M Angeles; C A Czajkowski
Characterization of transport-mediated methotrexate resistance in human tumor cells with antibodies to the membrane carrier for methotrexate and tetrahydrofolate cofactors.
The Journal of biological chemistry 1992;267(32):23253-60.
1991: Larry H Matherly; C A Czajkowski; S M Angeles
Identification of a highly glycosylated methotrexate membrane carrier in K562 human erythroleukemia cells up-regulated for tetrahydrofolate cofactor and methotrexate transport.
Cancer research 1991;51(13):3420-6.
1990: Larry H Matherly; S P Muench
Evidence for a localized conversion of endogenous tetrahydrofolate cofactors to dihydrofolate as an important element in antifolate action in murine leukemia cells.
Biochemical pharmacology 1990;39(12):2005-14.
1990: Larry H Matherly; C A Czajkowski; S P Muench; J T Psiakis
Role for cytosolic folate-binding proteins in the compartmentation of endogenous tetrahydrofolates and the 5-formyl tetrahydrofolate-mediated enhancement of 5-fluoro-2'-deoxyuridine antitumor activity in vitro.
Cancer research 1990;50(11):3262-9.
1989: Larry H Matherly; John D Schuetz; E Westin; I David Goldman
A method for the synchronization of cultured cells with aphidicolin: application to the large-scale synchronization of L1210 cells and the study of the cell cycle regulation of thymidylate synthase and dihydrofolate reductase.
Analytical biochemistry 1989;182(2):338-45.
1989: John D Schuetz; E H Westin; Larry H Matherly; R Pincus; Paul Steven Swerdlow; I David Goldman
Membrane protein changes in an L1210 leukemia cell line with a translocation defect in the methotrexate-tetrahydrofolate cofactor transport carrier.
The Journal of biological chemistry 1989;264(27):16261-7.
1988: John D Schuetz; Larry H Matherly; E H Westin; I David Goldman
Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line.
The Journal of biological chemistry 1988;263(20):9840-7.
1987: Larry H Matherly; C K Barlowe; V M Phillips; I David Goldman
The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue.
The Journal of biological chemistry 1987;262(2):710-7.
1987: I David Goldman; Larry H Matherly
Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates.
NCI monographs : a publication of the National Cancer Institute 1987;(5):17-26.
1987: Larry H Matherly; Richard Seither; I David Goldman
Metabolism of the diaminoantifolates: biosynthesis and pharmacology of the 7-hydroxyl and polyglutamyl metabolites of methotrexate and related antifolates.
Pharmacology & therapeutics 1987;35(1-2):27-56.
1986: Larry H Matherly; C K Barlowe; I David Goldman
Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells.
Cancer research 1986;46(2):588-93.
1985: Larry H Matherly; M K Voss; L A Anderson; D W Fry; I David Goldman
Enhanced polyglutamylation of aminopterin relative to methotrexate in the Ehrlich ascites tumor cell in vitro.
Cancer research 1985;45(3):1073-8.
1985: I David Goldman; Larry H Matherly
The cellular pharmacology of methotrexate.
Pharmacology & therapeutics 1985;28(1):77-102.
1984: Larry H Matherly; L A Anderson; I David Goldman
Role of the cellular oxidation-reduction state in methotrexate binding to dihydrofolate reductase and dissociation induced by reduced folates.
Cancer research 1984;44(6):2325-30.
1984: Gérard Fabre; I Fabre; Larry H Matherly; J P Cano; I David Goldman
Synthesis and properties of 7-hydroxymethotrexate polyglutamyl derivatives in Ehrlich ascites tumor cells in vitro.
The Journal of biological chemistry 1984;259(8):5066-72.
1984: Gérard Fabre; Larry H Matherly; I Fabre; J P Cano; I David Goldman
Interactions between 7-hydroxymethotrexate and methotrexate at the cellular level in the Ehrlich ascites tumor in vitro.
Cancer research 1984;44(3):970-5.
1983: Gérard Fabre; Larry H Matherly; R Favre; Jacques Catalin; J P Cano
In vitro formation of polyglutamyl derivatives of methotrexate and 7-hydroxymethotrexate in human lymphoblastic leukemia cells.
Cancer research 1983;43(10):4648-52.
1983: Larry H Matherly; D W Fry; I David Goldman
Role of methotrexate polyglutamylation and cellular energy metabolism in inhibition of methotrexate binding to dihydrofolate reductase by 5-formyltetrahydrofolate in Ehrlich ascites tumor cells in vitro.
Cancer research 1983;43(6):2694-9.
1983: Larry H Matherly; A T Phillips
Identification of the enol tautomer of imidazolone propionate as the urocanase reaction product.
Archives of biochemistry and biophysics 1983;220(1):314-7.
1982: Larry H Matherly; K A Johnson; A T Phillips
Transient-state kinetic analysis of urocanase.
Biochemistry 1982;21(11):2795-8.
1982: Larry H Matherly; C W DeBrosse; A T Phillips
A covalent nicotinamide adenine dinucleotide intermediate in the urocanase reaction.
Biochemistry 1982;21(11):2789-94.
1981: R M Egan; Larry H Matherly; A T Phillips
Mechanism of urocanase as studied by deuterium isotope effects and labeling patterns.
Biochemistry 1981;20(1):132-7.
1980: Larry H Matherly; A T Phillips
Substrate-mediated inactivation of urocanase from Pseudomonas putida. Evidence for an essential sulfhydryl group.
Biochemistry 1980;19(25):5814-8.