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Lynn Matrisian

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In Kyu Lee; Lynn M Matrisian; Jung Ho Shim; Michael N. VanSaun; D Lee Gorden
Increased metastases are associated with inflammation and matrix metalloproteinase-9 activity at incision sites in a murine model of peritoneal dissemination of colorectal cancer.
Xiaohong Li; Lynn M Matrisian; Yu Shyr; Julie A Sterling; Robert L Vessella; Kang-Hsien Fan; Simon W Hayward; Neil A Bhowmick
Loss of TGF-β responsiveness in prostate stromal cells alters chemokine levels and facilitates the development of mixed osteoblastic/osteolytic bone lesions.
Rachelle W Johnson; Mai P Nguyen; Susan Padalecki; Barry Grubbs; Alyssa R Merkel; Babatunde Oyajobi; Lynn M Matrisian; Gregory R Mundy; Julie A Sterling
TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling.

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All Publications

2013: In Kyu Lee; Lynn M Matrisian; Jung Ho Shim; Michael N. VanSaun; D Lee Gorden
Increased metastases are associated with inflammation and matrix metalloproteinase-9 activity at incision sites in a murine model of peritoneal dissemination of colorectal cancer.
The Journal of surgical research 2013;180(2):252-9.
2012: Xiaohong Li; Lynn M Matrisian; Yu Shyr; Julie A Sterling; Robert L Vessella; Kang-Hsien Fan; Simon W Hayward; Neil A Bhowmick
Loss of TGF-β responsiveness in prostate stromal cells alters chemokine levels and facilitates the development of mixed osteoblastic/osteolytic bone lesions.
Molecular cancer research : MCR 2012;10(4):494-503.
2011: Rachelle W Johnson; Mai P Nguyen; Susan Padalecki; Barry Grubbs; Alyssa R Merkel; Babatunde Oyajobi; Lynn M Matrisian; Gregory R Mundy; Julie A Sterling
TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling.
Cancer research 2011;71(3):822-31.
2011: Swati Biswas; Anwesa Chakrabarti; James Edwards; Rachelle Johnson; Scott Lonning; Lynn M Matrisian; Jeffry S Nyman; Daniel S Perrien; Tapasi Rana; Yu Shyr; Julie Sterling; JoAnn Alvarez; Austin Ayres; Gregory R Mundy
Anti-transforming growth factor ß antibody treatment rescues bone loss and prevents breast cancer metastasis to bone.
PloS one 2011;6(11):e27090.
2011: D Lee Gorden; Pavlina T Ivanova; Lynn M Matrisian; J Oliver McIntyre; David S Myers; Michael N. VanSaun; J Kelly Wright; H Alex Brown
Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model.
PloS one 2011;6(8):e22775.
2010: Michelle D Martin; Gert-Jan Kremers; Kurt W Short; Jonathan V Rocheleau; Lei Xu; David W Piston; Lynn M Matrisian; D Lee Gorden
Rapid extravasation and establishment of breast cancer micrometastases in the liver microenvironment.
Molecular cancer research : MCR 2010;8(10):1319-27.
2010: Alexandre Bruni-Cardoso; Conor C Lynch; Rafaela Rosa-Ribeiro; Lynn M Matrisian; Hernandes F Carvalho
MMP-2 contributes to the development of the mouse ventral prostate by impacting epithelial growth and morphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 2010;239(9):2386-92.
2010: Md Jashim Uddin; Brenda C Crews; Anna L Blobaum; Philip J Kingsley; D Lee Gorden; J Oliver McIntyre; Lynn M Matrisian; Kotha Subbaramaiah; Andrew J Dannenberg; David W Piston; Lawrence J Marnett
Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents.
Cancer research 2010;70(9):3618-27.
2010: Conor C Lynch; Tracy Vargo-Gogola; Lynn M Matrisian; Barbara Fingleton
Cleavage of E-Cadherin by Matrix Metalloproteinase-7 Promotes Cellular Proliferation in Nontransformed Cell Lines via Activation of RhoA.
Journal of oncology 2010;2010():530745.
2010: J Oliver McIntyre; Randy L Scherer; Lynn M Matrisian
Near-infrared optical proteolytic beacons for in vivo imaging of matrix metalloproteinase activity.
Methods in molecular biology (Clifton, N.J.) 2010;622():279-304.
2009: Martin A Cheever; James P Allison; Andrea S Ferris; Olivera J Finn; Benjamin M Hastings; Toby T Hecht; Ira Mellman; Sheila A Prindiville; Jaye L Viner; Louis M Weiner; Lynn M Matrisian
The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(17):5323-37.
2009: Sophie Thiolloy; Jennifer Halpern; Ginger E Holt; Herbert S Schwartz; Gregory R Mundy; Lynn M Matrisian; Conor C Lynch
Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase-9, contributes to tumor-induced osteolysis.
Cancer research 2009;69(16):6747-55.
2009: J Oliver McIntyre; Lynn M Matrisian
Optical proteolytic beacons for in vivo detection of matrix metalloproteinase activity.
Methods in molecular biology (Clifton, N.J.) 2009;539():155-74.
2008: Mark J Sinnamon; Kathy J Carter; Barbara Fingleton; Lynn M Matrisian
Matrix metalloproteinase-9 contributes to intestinal tumourigenesis in the adenomatous polyposis coli multiple intestinal neoplasia mouse.
International journal of experimental pathology 2008;89(6):466-75.
2008: Randy L Scherer; J Oliver McIntyre; Lynn M Matrisian
Imaging matrix metalloproteinases in cancer.
Cancer metastasis reviews 2008;27(4):679-90.
2008: Lisa J McCawley; Jane Wright; Bonnie J Lafleur; Howard C Crawford; Lynn M Matrisian
Keratinocyte expression of MMP3 enhances differentiation and prevents tumor establishment.
The American journal of pathology 2008;173(5):1528-39.
2008: Gary S Dorfman; Theodore S Lawrence; Lynn M Matrisian
The Translational Research Working Group developmental pathway for interventive devices.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(18):5700-6.
2008: Richard L Schilsky; Gary Gordon; Tona M Gilmer; Sara A Courtneidge; Lynn M Matrisian; Oren Grad; William G Nelson
The Translational Research Working Group developmental pathway for anticancer agents (drugs or biologics).
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(18):5685-91.
2008: Gary S Dorfman; Daniel C Sullivan; Mitchell D Schnall; Lynn M Matrisian
The Translational Research Working Group developmental pathway for image-based assessment modalities.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(18):5678-84.
2008: Ernest T Hawk; Lynn M Matrisian; William G Nelson; Gary S Dorfman; Lisa Stevens; Jennifer Kwok; Jaye Viner; Judith Hautala; Oren Grad
The Translational Research Working Group developmental pathways: introduction and overview.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(18):5664-71.
2008: C Chad Quarles; Martin Lepage; D Lee Gorden; Barbara Fingleton; Thomas E Yankeelov; Ronald R Price; Lynn M Matrisian; John C Gore; J Oliver McIntyre
Functional colonography of Min mice using dark lumen dynamic contrast-enhanced MRI.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2008;60(3):718-26.
2008: Michelle D Martin; Kathy J Carter; Sharon R Jean-Philippe; Mayland Chang; Shahriar Mobashery; Sophie Thiolloy; Conor C Lynch; Lynn M Matrisian; Barbara Fingleton
Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background.
Cancer research 2008;68(15):6251-9.
2008: Ines Macias-Perez; Corina Borza; Xiwu Chen; Xuexian Yan; Raquel Ibanez; Glenda Mernaugh; Lynn M Matrisian; Roy Zent; Ambra Pozzi
Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer.
Cancer research 2008;68(15):6127-35.
2008: Randy L Scherer; Michael N. VanSaun; J Oliver McIntyre; Lynn M Matrisian
Optical imaging of matrix metalloproteinase-7 activity in vivo using a proteolytic nanobeacon.
Molecular imaging 2008;7(3):118-31.
2008: Mark J Sinnamon; Kathy J Carter; Lauren P Sims; Bonnie J Lafleur; Barbara Fingleton; Lynn M Matrisian
A protective role of mast cells in intestinal tumorigenesis.
Carcinogenesis 2008;29(4):880-6.
2008: Michelle D Martin; Barbara Fingleton; Conor C Lynch; Sam Wells; J Oliver McIntyre; David W Piston; Lynn M Matrisian
Establishment and quantitative imaging of a 3D lung organotypic model of mammary tumor outgrowth.
Clinical & experimental metastasis 2008;25(8):877-85.
2008: Li Yang; Jianhua Huang; Xiubao Ren; Agnieszka E Gorska; Anna Chytil; Mary E Aakre; David P Carbone; Lynn M Matrisian; Ann Richmond; P Charles Lin; Harold L Moses
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis.
Cancer cell 2008;13(1):23-35.
2007: Michelle D Martin; Lynn M Matrisian
The other side of MMPs: protective roles in tumor progression.
Cancer metastasis reviews 2007;26(3-4):717-24.
2007: Martin Lepage; William C Dow; Marco Melchior; Ying You; Barbara Fingleton; C Chad Quarles; Claude Pépin; John C Gore; Lynn M Matrisian; J Oliver McIntyre
Noninvasive detection of matrix metalloproteinase activity in vivo using a novel magnetic resonance imaging contrast agent with a solubility switch.
Molecular imaging 2007;6(6):393-403.
2007: Carlos López-Otín; Lynn M Matrisian
Emerging roles of proteases in tumour suppression.
Nature reviews. Cancer 2007;7(10):800-8.
2007: D Lee Gorden; Barbara Fingleton; Howard C Crawford; Duco E Jansen; Martin Lepage; Lynn M Matrisian
Resident stromal cell-derived MMP-9 promotes the growth of colorectal metastases in the liver microenvironment.
International journal of cancer. Journal international du cancer 2007;121(3):495-500.
2007: Conor C Lynch; Tracy Vargo-Gogola; Michelle D Martin; Barbara Fingleton; Howard C Crawford; Lynn M Matrisian
Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor.
Cancer research 2007;67(14):6760-7.
2007: Barbara Fingleton; Kathy J Carter; Lynn M Matrisian
Loss of functional Fas ligand enhances intestinal tumorigenesis in the Min mouse model.
Cancer research 2007;67(10):4800-6.
2007: Laura M DeBusk; Alisha J Russell; Kohzoh Imai; Lynn M Matrisian
In the forefront of basic and translational cancer research: Seventh Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association.
Cancer research 2007;67(10):4556-9.
2007: Donald R Schwartz; Kamiar Moin; Bin Yao; Lynn M Matrisian; Lisa M Coussens; Thomas H Bugge; Barbara Fingleton; Heath Acuff Elrod; Mark Sinnamon; HIND NASSAR; Adrian E Platts; Stephen A Krawetz; Bruce E Linebaugh; Bonnie F Sloane
Hu/Mu ProtIn oligonucleotide microarray: dual-species array for profiling protease and protease inhibitor gene expression in tumors and their microenvironment.
Molecular cancer research : MCR 2007;5(5):443-54.
2007: Ian Nicoud; Christopher M Jones; Janene M Pierce; T Mark Earl; Lynn M Matrisian; Ravi Chari; D Lee Gorden
Warm hepatic ischemia-reperfusion promotes growth of colorectal carcinoma micrometastases in mouse liver via matrix metalloproteinase-9 induction.
Cancer research 2007;67(6):2720-8.
2007: Barbara Fingleton; William C Powell; Howard C Crawford; John R Couchman; Lynn M Matrisian
A rat monoclonal antibody that recognizes pro- and active MMP-7 indicates polarized expression in vivo.
Hybridoma (2005) 2007;26(1):22-7.
2006: Jennifer L Taylor; Jessica M Hattle; Steven A Dreitz; Jolynn Troudt; Linda S Izzo; Randall J Basaraba; Ian M Orme; Lynn M Matrisian; Angelo A Izzo
Role for matrix metalloproteinase 9 in granuloma formation during pulmonary Mycobacterium tuberculosis infection.
Infection and immunity 2006;74(11):6135-44.
2006: Heath Acuff Elrod; Mark Sinnamon; Barbara Fingleton; Braden Boone; Shawn Levy; Xiwu Chen; Ambra Pozzi; David P Carbone; Donald R Schwartz; Kamiar Moin; Bonnie F Sloane; Lynn M Matrisian
Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer.
Cancer research 2006;66(16):7968-75.
2006: Xiao Qin; Matthew A Corriere; Lynn M Matrisian; Raul J Guzman
Matrix metalloproteinase inhibition attenuates aortic calcification.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(7):1510-6.
2006: Eben Rosenthal; Lynn M Matrisian
Matrix metalloproteases in head and neck cancer.
Head & neck 2006;28(7):639-48.
2006: Merry Lindsey; G Patricia Escobar; Rupak Mukherjee; Danielle K Goshorn; Nina J Sheats; James A Bruce; I Matthew Mains; Jennifer K Hendrick; Kenneth W Hewett; Robert G Gourdie; Lynn M Matrisian; Francis G Spinale
Matrix metalloproteinase-7 affects connexin-43 levels, electrical conduction, and survival after myocardial infarction.
Circulation 2006;113(25):2919-28.
2006: Menon Ramkumar; J Oliver McIntyre; Lynn M Matrisian; Stephen J Fortunato
Salivary proteinase activity: a potential biomarker for preterm premature rupture of the membranes.
American journal of obstetrics and gynecology 2006;194(6):1609-15; discussion 1615.
2006: Michael N. VanSaun; Lynn M Matrisian
Matrix metalloproteinases and cellular motility in development and disease.
Birth defects research. Part C, Embryo today : reviews 2006;78(1):69-79.
2006: F Gregory Buchanan; D Lee Gorden; Pranathi Matta; Qiong Shi; Lynn M Matrisian; Raymond DuBois
Role of beta-arrestin 1 in the metastatic progression of colorectal cancer.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1492-7.
2006: Jennifer Halpern; Conor C Lynch; Jonathan Fleming; David Hamming; Michelle D Martin; Herbert S Schwartz; Lynn M Matrisian; Ginger E Holt
The application of a murine bone bioreactor as a model of tumor: bone interaction.
Clinical & experimental metastasis 2006;23(7-8):345-56.
2006: Wenyue Zhang; Lynn M Matrisian; Kenn Holmbeck; Catherine C Vick; Eben Rosenthal
Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo.
BMC cancer 2006;6():52.
2006: Heath Acuff Elrod; Kathy J Carter; Barbara Fingleton; D Lee Gorden; Lynn M Matrisian
Matrix metalloproteinase-9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment.
Cancer research 2006;66(1):259-66.
2005: Xiwu Chen; Yan Su; Barbara Fingleton; Heath Acuff Elrod; Lynn M Matrisian; Roy Zent; Ambra Pozzi
Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells.
International journal of cancer. Journal international du cancer 2005;116(1):52-61.
2005: Conor C Lynch; Atsuya Hikosaka; Heath Acuff Elrod; Michelle D Martin; Noriyasu Kawai; Rakesh K Singh; Tracy Vargo-Gogola; Jennifer L Begtrup; Todd E Peterson; Barbara Fingleton; Tomoyuki Shirai; Lynn M Matrisian; Mitsuru Futakuchi
MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL.
Cancer cell 2005;7(5):485-96.
2005: Permila C Harrell; Lisa J McCawley; Barbara Fingleton; J Oliver McIntyre; Lynn M Matrisian
Proliferative effects of apical, but not basal, matrix metalloproteinase-7 activity in polarized MDCK cells.
Experimental cell research 2005;303(2):308-20.
2005: Madappa N Kundranda; Melodie Henderson; Kathy J Carter; Lee Gorden; Awadh Amir Binhazim; Sanhita Ray; Trevor Baptiste; Masih Shokrani; Maria L Leite-Browning; Willi Jahnen-Dechent; Lynn M Matrisian; Josiah Ochieng
The serum glycoprotein fetuin-A promotes Lewis lung carcinoma tumorigenesis via adhesive-dependent and adhesive-independent mechanisms.
Cancer research 2005;65(2):499-506.
2005: Xiwu Chen; Yan Su; Barbara Fingleton; Heath Acuff Elrod; Lynn M Matrisian; Roy Zent; Ambra Pozzi
An orthotopic model of lung cancer to analyze primary and metastatic NSCLC growth in integrin alpha1-null mice.
Clinical & experimental metastasis 2005;22(2):185-93.
2004: Barbara Fingleton; Menon Ramkumar; Kathy J Carter; P Dawn Overstreet; David L Hachey; Lynn M Matrisian; J Oliver McIntyre
Proteinase activity in human and murine saliva as a biomarker for proteinase inhibitor efficacy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(23):7865-74.
2004: Mark D Gustavson; Howard C Crawford; Barbara Fingleton; Lynn M Matrisian
Tcf binding sequence and position determines beta-catenin and Lef-1 responsiveness of MMP-7 promoters.
Molecular carcinogenesis 2004;41(3):125-39.
2004: Li Yang; Laura M DeBusk; Koari Fukuda; Barbara Fingleton; Brenda Green-Jarvis; Yu Shyr; Lynn M Matrisian; David P Carbone; P Charles Lin
Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis.
Cancer cell 2004;6(4):409-21.
2004: Lisa J McCawley; Howard C Crawford; Lloyd E King; John S Mudgett; Lynn M Matrisian
A protective role for matrix metalloproteinase-3 in squamous cell carcinoma.
Cancer research 2004;64(19):6965-72.
2004: Fazilat F Mohammed; David S Smookler; Suzanne E M Taylor; Barbara Fingleton; Zamaneh Kassiri; Otto H Sanchez; Jane L English; Lynn M Matrisian; Billie Au; Wen-Chen Yeh; Rama Khokha
Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration.
Nature genetics 2004;36(9):969-77.
2004: Madappa N Kundranda; Sanhita Ray; Margaret Saria; David Friedman; Lynn M Matrisian; Pavel Lukyanov; Josiah Ochieng
Annexins expressed on the cell surface serve as receptors for adhesion to immobilized fetuin-A.
Biochimica et biophysica acta 2004;1693(2):111-23.
2004: Maria L Leite-Browning; Lisa J McCawley; Willi Jahnen-Dechent; Lloyd E King; Lynn M Matrisian; Josiah Ochieng
Alpha 2-HS glycoprotein (fetuin-A) modulates murine skin tumorigenesis.
International journal of oncology 2004;25(2):319-24.
2004: Diana L Hulboy; Shiva Gautam; Barbara Fingleton; Lynn M Matrisian
The influence of matrix metalloproteinase-7 on early mammary tumorigenesis in the multiple intestinal neoplasia mouse.
Oncology reports 2004;12(1):13-7.
2004: Conor C Lynch; Howard C Crawford; Lynn M Matrisian; SUSAN MCDONNELL
Epidermal growth factor upregulates matrix metalloproteinase-7 expression through activation of PEA3 transcription factors.
International journal of oncology 2004;24(6):1565-72.
2004: Yves A DeClerck; Arthur M Mercurio; M Sharon Stack; Harold A Chapman; Mary M Zutter; Ruth J Muschel; Avraham Raz; Lynn M Matrisian; Bonnie F Sloane; Agnes Noel; Mary J Hendrix; Lisa M Coussens; Martin Padarathsingh
Proteases, extracellular matrix, and cancer: a workshop of the path B study section.
The American journal of pathology 2004;164(4):1131-9.
2004: J Oliver McIntyre; Barbara Fingleton; K Sam Wells; David W Piston; Conor C Lynch; Shiva Gautam; Lynn M Matrisian
Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity.
The Biochemical journal 2004;377(Pt 3):617-28.
2004: Rebecca Wagenaar-Miller; Lee Gorden; Lynn M Matrisian
Matrix metalloproteinases in colorectal cancer: is it worth talking about?
Cancer metastasis reviews 2004;23(1-2):119-35.
2003: J Oliver McIntyre; Lynn M Matrisian
Molecular imaging of proteolytic activity in cancer.
Journal of cellular biochemistry 2003;90(6):1087-97.
2003: Lynn M Matrisian; George W Sledge; Suresh Mohla
Extracellular proteolysis and cancer: meeting summary and future directions.
Cancer research 2003;63(19):6105-9.
2003: Howard C Crawford; Uma Krishna; Dawn A Israel; Lynn M Matrisian; M Kay Washington; Richard M Peek
Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa.
Gastroenterology 2003;125(4):1125-36.
2003: Sergey Filippov; Ingrid Caras; Richard Murray; Lynn M Matrisian; Harold A Chapman; Steven Shapiro; Stephen J Weiss
Matrilysin-dependent elastolysis by human macrophages.
The Journal of experimental medicine 2003;198(6):925-35.
2003: Christine Rivat; Nathalie Le Floch; Michèle Sabbah; Isabelle Teyrol; Gérard Redeuilh; Erik Bruyneel; Marc Mareel; Lynn M Matrisian; Howard C Crawford; Christian Gespach; Samir Attoub
Synergistic cooperation between the AP-1 and LEF-1 transcription factors in activation of the matrilysin promoter by the src oncogene: implications in cellular invasion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(12):1721-3.
2003: Rebecca Wagenaar-Miller; G Hanley; RL Shattuck-Brandt; Raymond DuBois; R L Bell; Lynn M Matrisian; D W Morgan
Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction.
British journal of cancer 2003;88(9):1445-52.
2003: Tomoko Kure; Jin-Hong Chang; Takuji Kato; Everardo Hernández-Quintela; Hongqing Ye; Paul Chung-Shien Lu; Lynn M Matrisian; Damien Gatinel; Steven Shapiro; Faris Gosheh; Dimitri T Azar; Faris Gosheh
Corneal neovascularization after excimer keratectomy wounds in matrilysin-deficient mice.
Investigative ophthalmology & visual science 2003;44(1):137-44.
2002: Tracy Vargo-Gogola; Howard C Crawford; Barbara Fingleton; Lynn M Matrisian
Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand.
Archives of biochemistry and biophysics 2002;408(2):155-61.
2002: Conor C Lynch; Lynn M Matrisian
Matrix metalloproteinases in tumor-host cell communication.
Differentiation; research in biological diversity 2002;70(9-10):561-73.
2002: Gerald R Cunha; Lynn M Matrisian
It's not my fault, blame it on my microenvironment.
Differentiation; research in biological diversity 2002;70(9-10):469-72.
2002: Maria L Leite-Browning; Lisa J McCawley; OKSOON CHOI; Lynn M Matrisian; Josiah Ochieng
Interactions of alpha2-HS-glycoprotein (fetuin) with MMP-3 and murine squamous cell carcinoma cells.
International journal of oncology 2002;21(5):965-71.
2002: Tracy Vargo-Gogola; Barbara Fingleton; Howard C Crawford; Lynn M Matrisian
Matrilysin (matrix metalloproteinase-7) selects for apoptosis-resistant mammary cells in vivo.
Cancer research 2002;62(19):5559-63.
2002: Ken J Newell; Lynn M Matrisian; David K Driman
Matrilysin (matrix metalloproteinase-7) expression in ulcerative colitis-related tumorigenesis.
Molecular carcinogenesis 2002;34(2):59-63.
2002: Howard C Crawford; Charles R Scoggins; M Kay Washington; Lynn M Matrisian; Steven D Leach
Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas.
The Journal of clinical investigation 2002;109(11):1437-44.
2002: Lisa M Coussens; Barbara Fingleton; Lynn M Matrisian
Matrix metalloproteinase inhibitors and cancer: trials and tribulations.
Science (New York, N.Y.) 2002;295(5564):2387-92.
2002: Constance E Brinckerhoff; Lynn M Matrisian
Matrix metalloproteinases: a tail of a frog that became a prince.
Nature reviews. Molecular cell biology 2002;3(3):207-14.
2001: Barbara Fingleton; Tracy Vargo-Gogola; Howard C Crawford; Lynn M Matrisian
Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosis.
Neoplasia (New York, N.Y.) 2001;3(6):459-68.
2001: Lisa J McCawley; Lynn M Matrisian
Matrix metalloproteinases: they're not just for matrix anymore!
Current opinion in cell biology 2001;13(5):534-40.
2001: Diana L Hulboy; Lynn M Matrisian; Howard C Crawford
Loss of JunB activity enhances stromelysin 1 expression in a model of the epithelial-to-mesenchymal transition of mouse skin tumors.
Molecular and cellular biology 2001;21(16):5478-87.
2001: R Agnihotri; Howard C Crawford; Hirotaka Haro; Lynn M Matrisian; Matthew C Havrda; Lucy Liaw
Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin).
The Journal of biological chemistry 2001;276(30):28261-7.
2001: Dana M Brantley; CL Chen; Rebecca Cook; PB Bushdid; J L Bradberry; F Kittrell; D Medina; Lynn M Matrisian; LD Kerr; Fiona E Yull
Nuclear factor-kappaB (NF-kappaB) regulates proliferation and branching in mouse mammary epithelium.
Molecular biology of the cell 2001;12(5):1445-55.
2001: Lynn M Matrisian; G R Cunha; Suresh Mohla
Epithelial-stromal interactions and tumor progression: meeting summary and future directions.
Cancer research 2001;61(9):3844-6.
2001: Rebecca Wagenaar-Miller; Howard C Crawford; Lynn M Matrisian
Stabilized beta-catenin immortalizes colonic epithelial cells.
Cancer research 2001;61(5):2097-104.
2001: Howard C Crawford; Barbara Fingleton; Mark D Gustavson; Natasza A Kurpios; Rebecca Wagenaar-Miller; J A Hassell; Lynn M Matrisian
The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors.
Molecular and cellular biology 2001;21(4):1370-83.
2001: Lisa J McCawley; Lynn M Matrisian
Tumor progression: defining the soil round the tumor seed.
Current biology : CB 2001;11(1):R25-7.
2001: Veerle Noë; Barbara Fingleton; K Jacobs; Howard C Crawford; S Vermeulen; Wim F A Steelant; Erik Bruyneel; Lynn M Matrisian; Marc Mareel
Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1.
Journal of cell science 2001;114(Pt 1):111-118.
2000: Lynn M Matrisian
Quick guide. Matrix metalloproteinases.
Current biology : CB 2000;10(19):R692.
2000: Randy Fenrick; Lilin Wang; John Nip; Joseph M Amann; Robert J. Rooney; Jennifer Walker-Daniels; Howard C Crawford; Diana L Hulboy; Michael S Kinch; Lynn M Matrisian; Scott W Hiebert
TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1.
Molecular and cellular biology 2000;20(16):5828-39.
2000: Lisa J McCawley; Lynn M Matrisian
Matrix metalloproteinases: multifunctional contributors to tumor progression.
Molecular medicine today 2000;6(4):149-56.
2000: John MacDougall; Lynn M Matrisian
Targets of extinction: identification of genes whose expression is repressed as a consequence of somatic fusion between cells representing basal and luminal mammary epithelial phenotypes.
Journal of cell science 2000;113 ( Pt 3)():409-23.
2000: Hirotaka Haro; Howard C Crawford; Barbara Fingleton; Kenichi Shinomiya; Dan M Spengler; Lynn M Matrisian
Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption.
The Journal of clinical investigation 2000;105(2):143-50.
2000: Hirotaka Haro; Howard C Crawford; Barbara Fingleton; John MacDougall; Kenichi Shinomiya; Dan M Spengler; Lynn M Matrisian
Matrix metalloproteinase-3-dependent generation of a macrophage chemoattractant in a model of herniated disc resorption.
The Journal of clinical investigation 2000;105(2):133-41.
1999: W C Powell; Barbara Fingleton; CL Wilson; M Boothby; Lynn M Matrisian
The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis.
Current biology : CB 1999;9(24):1441-7.
1999: Lynn M Matrisian
Cancer biology: extracellular proteinases in malignancy.
Current biology : CB 1999;9(20):R776-8.
1999: Howard C Crawford; Barbara Fingleton; LA Rudolph-Owen; Kathleen Heppner Goss; Bonnee Rubinfeld; Paul Polakis; Lynn M Matrisian
The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors.
Oncogene 1999;18(18):2883-91.
1999: RL Shattuck-Brandt; L W Lamps; Kathleen Heppner Goss; Raymond DuBois; Lynn M Matrisian
Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms.
Molecular carcinogenesis 1999;24(3):177-87.
1999: Barbara Fingleton; Kathleen Heppner Goss; Howard C Crawford; Lynn M Matrisian
Matrilysin in early stage intestinal tumorigenesis.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1999;107(1):102-10.
1998: LA Rudolph-Owen; R Chan; W J Muller; Lynn M Matrisian
The matrix metalloproteinase matrilysin influences early-stage mammary tumorigenesis.
Cancer research 1998;58(23):5500-6.
1998: LA Rudolph-Owen; Ov D Slayden; Lynn M Matrisian; Robert M Brenner
Matrix metalloproteinase expression in Macaca mulatta endometrium: evidence for zone-specific regulatory tissue gradients.
Biology of reproduction 1998;59(6):1349-59.
1998: Kathleen Heppner Goss; P D Brown; Lynn M Matrisian
Differing effects of endogenous and synthetic inhibitors of metalloproteinases on intestinal tumorigenesis.
International journal of cancer. Journal international du cancer 1998;78(5):629-35.
1998: Howard C Crawford; Lynn M Matrisian; Lucy Liaw
Distinct roles of osteopontin in host defense activity and tumor survival during squamous cell carcinoma progression in vivo.
Cancer research 1998;58(22):5206-15.
1998: LA Rudolph-Owen; Lynn M Matrisian
Matrix metalloproteinases in remodeling of the normal and neoplastic mammary gland.
Journal of mammary gland biology and neoplasia 1998;3(2):177-89.
1998: LA Rudolph-Owen; P Cannon; Lynn M Matrisian
Overexpression of the matrix metalloproteinase matrilysin results in premature mammary gland differentiation and male infertility.
Molecular biology of the cell 1998;9(2):421-35.
1997: LA Rudolph-Owen; Diana L Hulboy; CL Wilson; John S Mudgett; Lynn M Matrisian
Coordinate expression of matrix metalloproteinase family members in the uterus of normal, matrilysin-deficient, and stromelysin-1-deficient mice.
Endocrinology 1997;138(11):4902-11.
1997: Ann F Chambers; Lynn M Matrisian
Changing views of the role of matrix metalloproteinases in metastasis.
Journal of the National Cancer Institute 1997;89(17):1260-70.
1997: K L Bruner; Lynn M Matrisian; W H Rodgers; F Gorstein; Kevin G Osteen
Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice.
The Journal of clinical investigation 1997;99(12):2851-7.
1997: CL Wilson; Kathleen Heppner Goss; Patricia A Labosky; Brigid L M Hogan; Lynn M Matrisian
Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1402-7.
1997: Diana L Hulboy; L A Rudolph; Lynn M Matrisian
Matrix metalloproteinases as mediators of reproductive function.
Molecular human reproduction 1997;3(1):27-45.
1996: Robert M Brenner; L Rudolph; Lynn M Matrisian; Ov D Slayden
Non-human primate models; artificial menstrual cycles, endometrial matrix metalloproteinases and s.c. endometrial grafts.
Human reproduction (Oxford, England) 1996;11 Suppl 2():150-64.
1996: W C Powell; F E Domann; J M Mitchen; Lynn M Matrisian; Raymond B Nagle; George Bowden
Matrilysin expression in the involuting rat ventral prostate.
The Prostate 1996;29(3):159-68.
1996: Kathleen Heppner Goss; Lynn M Matrisian; R A Jensen; W H Rodgers
Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.
The American journal of pathology 1996;149(1):273-82.
1996: C L Wilson; Lynn M Matrisian
Matrilysin: an epithelial matrix metalloproteinase with potentially novel functions.
The international journal of biochemistry & cell biology 1996;28(2):123-36.
1996: M Gaire; C D Barro; LD Kerr; F Carlisle; Lynn M Matrisian
Protein kinase C isotypes required for phorbol-ester induction of stromelysin-1 in rat fibroblasts.
Molecular carcinogenesis 1996;15(2):124-33.
1996: J D Knox; Douglas R Boreham; J A Walker; DP Morrison; Lynn M Matrisian; Raymond B Nagle; George Bowden
Mapping of the metalloproteinase gene matrilysin (MMP7) to human chromosome 11q21-->q22.
Cytogenetics and cell genetics 1996;72(2-3):179-82.
1996: W C Powell; Lynn M Matrisian
Complex roles of matrix metalloproteinases in tumor progression.
Current topics in microbiology and immunology 1996;213 ( Pt 1)():1-21.
1996: Howard C Crawford; Lynn M Matrisian
Mechanisms controlling the transcription of matrix metalloproteinase genes in normal and neoplastic cells.
Enzyme & protein 1996;49(1-3):20-37.
1996: J P Witty; S A Foster; G P Stricklin; Lynn M Matrisian; P H Stern
Parathyroid hormone-induced resorption in fetal rat limb bones is associated with production of the metalloproteinases collagenase and gelatinase B.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996;11(1):72-8.
1995: John MacDougall; Lynn M Matrisian
Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis.
Cancer metastasis reviews 1995;14(4):351-62.
1995: Lynn M Matrisian; M L Tykocinski; M Padarathsingh
Lessons to be learned from hematopoietic malignancies. Workshop report from the Division of Research Grants, National Institutes of Health.
The American journal of pathology 1995;147(5):1519-21.
1995: J P Witty; J H Wright; Lynn M Matrisian
Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development.
Molecular biology of the cell 1995;6(10):1287-303.
1995: K L Bruner; W H Rodgers; L I Gold; M Korc; J T Hargrove; Lynn M Matrisian; Kevin G Osteen
Transforming growth factor beta mediates the progesterone suppression of an epithelial metalloproteinase by adjacent stroma in the human endometrium.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(16):7362-6.
1995: C L Wilson; Kathleen Heppner Goss; L A Rudolph; Lynn M Matrisian
The metalloproteinase matrilysin is preferentially expressed by epithelial cells in a tissue-restricted pattern in the mouse.
Molecular biology of the cell 1995;6(7):851-69.
1995: J P Witty; T Lempka; Robert J Coffey; Lynn M Matrisian
Decreased tumor formation in 7,12-dimethylbenzanthracene-treated stromelysin-1 transgenic mice is associated with alterations in mammary epithelial cell apoptosis.
Cancer research 1995;55(7):1401-6.
1994: Kevin G Osteen; W H Rodgers; M Gaire; J T Hargrove; F Gorstein; Lynn M Matrisian
Stromal-epithelial interaction mediates steroidal regulation of metalloproteinase expression in human endometrium.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(21):10129-33.
1994: W H Rodgers; Lynn M Matrisian; Linda C Giudice; B Dsupin; P Cannon; Christina A Svitek; F Gorstein; Kevin G Osteen
Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones.
The Journal of clinical investigation 1994;94(3):946-53.
1994: J P Witty; SUSAN MCDONNELL; K J Newell; P Cannon; M Navre; Robert James Tressler; Lynn M Matrisian
Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivo.
Cancer research 1994;54(17):4805-12.
1994: J H Wright; SUSAN MCDONNELL; Giuseppe Portella; George Bowden; Allan Balmain; Lynn M Matrisian
A switch from stromal to tumor cell expression of stromelysin-1 mRNA associated with the conversion of squamous to spindle carcinomas during mouse skin tumor progression.
Molecular carcinogenesis 1994;10(4):207-15.
1994: K J Newell; J P Witty; W H Rodgers; Lynn M Matrisian
Expression and localization of matrix-degrading metalloproteinases during colorectal tumorigenesis.
Molecular carcinogenesis 1994;10(4):199-206.
1994: SUSAN MCDONNELL; J H Wright; M Gaire; Lynn M Matrisian
Expression and regulation of stromelysin and matrilysin by growth factors and oncogenes.
Biochemical Society transactions 1994;22(1):58-63.
1994: M Gaire; Z Magbanua; SUSAN MCDONNELL; L McNeil; David H Lovett; Lynn M Matrisian
Structure and expression of the human gene for the matrix metalloproteinase matrilysin.
The Journal of biological chemistry 1994;269(3):2032-40.
1994: Lynn M Matrisian; J Wright; K Newell; J P Witty
Matrix-degrading metalloproteinases in tumor progression.
Princess Takamatsu symposia 1994;24():152-61.
1994: Lynn M Matrisian; M Gaire; W H Rodgers; Kevin G Osteen
Metalloproteinase expression and hormonal regulation during tissue remodeling in the cycling human endometrium.
Contributions to nephrology 1994;107():94-100.
1994: Howard C Crawford; Lynn M Matrisian
Tumor and stromal expression of matrix metalloproteinases and their role in tumor progression.
Invasion & metastasis 1994;14(1-6):234-45.
1993: W H Rodgers; Kevin G Osteen; Lynn M Matrisian; M Navre; Linda C Giudice; F Gorstein
Expression and localization of matrilysin, a matrix metalloproteinase, in human endometrium during the reproductive cycle.
American journal of obstetrics and gynecology 1993;168(1 Pt 1):253-60.
1992: Lynn M Matrisian
The matrix-degrading metalloproteinases.
BioEssays : news and reviews in molecular, cellular and developmental biology 1992;14(7):455-63.
1992: Lynn M Matrisian; G L Ganser; LD Kerr; R W Pelton; L D Wood
Negative regulation of gene expression by TGF-beta.
Molecular reproduction and development 1992;32(2):111-20.
1992: LD Kerr; Bruce E Magun; Lynn M Matrisian
The role of C-Fos in growth factor regulation of stromelysin/transin gene expression.
Matrix (Stuttgart, Germany). Supplement 1992;1():176-83.
1991: G L Ganser; G P Stricklin; Lynn M Matrisian
EGF and TGF alpha influence in vitro lung development by the induction of matrix-degrading metalloproteinases.
The International journal of developmental biology 1991;35(4):453-61.
1991: Lynn M Matrisian; SUSAN MCDONNELL; D B Miller; M Navre; E A Seftor; M J Hendrix
The role of the matrix metalloproteinase stromelysin in the progression of squamous cell carcinomas.
The American journal of the medical sciences 1991;302(3):157-62.
1991: A J Park; Lynn M Matrisian; A F Kells; R Pearson; Z Y Yuan; M Navre
Mutational analysis of the transin (rat stromelysin) autoinhibitor region demonstrates a role for residues surrounding the "cysteine switch".
The Journal of biological chemistry 1991;266(3):1584-90.
1991: SUSAN MCDONNELL; M Navre; Robert J Coffey; Lynn M Matrisian
Expression and localization of the matrix metalloproteinase pump-1 (MMP-7) in human gastric and colon carcinomas.
Molecular carcinogenesis 1991;4(6):527-33.
1990: SUSAN MCDONNELL; Lynn M Matrisian
Stromelysin in tumor progression and metastasis.
Cancer metastasis reviews 1990;9(4):305-19.
1990: SUSAN MCDONNELL; LD Kerr; Lynn M Matrisian
Epidermal growth factor stimulation of stromelysin mRNA in rat fibroblasts requires induction of proto-oncogenes c-fos and c-jun and activation of protein kinase C.
Molecular and cellular biology 1990;10(8):4284-93.
1990: N J Sipes; D A Miller; C C Bascom; J K Winkler; Lynn M Matrisian; Harold L Moses
Altered regulation of protein disulfide isomerase in cells resistant to the growth-inhibitory effects of transforming growth factor beta 1.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(5):241-6.
1990: LD Kerr; D B Miller; Lynn M Matrisian
TGF-beta 1 inhibition of transin/stromelysin gene expression is mediated through a Fos binding sequence.
Cell 1990;61(2):267-78.
1990: Lynn M Matrisian; George Bowden
Stromelysin/transin and tumor progression.
Seminars in cancer biology 1990;1(2):107-15.
1988: LD Kerr; Jeffrey T Holt; Lynn M Matrisian
Growth factors regulate transin gene expression by c-fos-dependent and c-fos-independent pathways.
Science (New York, N.Y.) 1988;242(4884):1424-7.
1988: LD Kerr; N E Olashaw; Lynn M Matrisian
Transforming growth factor beta 1 and cAMP inhibit transcription of epidermal growth factor- and oncogene-induced transin RNA.
The Journal of biological chemistry 1988;263(32):16999-7005.
1988: L E Ostrowski; J Finch; P Krieg; Lynn M Matrisian; G Patskan; J F O'Connell; J Phillips; Thomas Slaga; R Breathnach; George Bowden
Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression.
Molecular carcinogenesis 1988;1(1):13-9.
1986: Lynn M Matrisian; George Bowden; P Krieg; G Fürstenberger; J P Briand; P Leroy; R Breathnach
The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(24):9413-7.