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Franz Matschinsky

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Changhong Li; Chengyang Liu; Franz M Matschinsky; Michael J Bennett; Jie Chen; Pan Chen; Yevgeny Daikhin; Nicolai Doliba; Ilana Nissim; Itzhak Nissim; Charles A Stanley; David Stokes; Marc Yudkoff; Tingting Zhang; Ali Naji
Regulation of glucagon secretion in normal and diabetic human islets by γ-hydroxybutyrate and glycine.
Franz M Matschinsky
GKAs for diabetes therapy: why no clinically useful drug after two decades of trying?
Maria Negahdar; Pål R Njølstad; Oddmund Søvik; Ingvild Aukrust; Torgeir Flatmark; Bente B Johansson; Rohit N Kulkarni; Franz M Matschinsky; Janne Molnes; Anders Molven; Lise Bjørkhaug
GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation.

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2013: Changhong Li; Chengyang Liu; Franz M Matschinsky; Michael J Bennett; Jie Chen; Pan Chen; Yevgeny Daikhin; Nicolai Doliba; Ilana Nissim; Itzhak Nissim; Charles A Stanley; David Stokes; Marc Yudkoff; Tingting Zhang; Ali Naji
Regulation of glucagon secretion in normal and diabetic human islets by γ-hydroxybutyrate and glycine.
The Journal of biological chemistry 2013;288(6):3938-51.
2013: Franz M Matschinsky
GKAs for diabetes therapy: why no clinically useful drug after two decades of trying?
Trends in pharmacological sciences 2013;34(2):90-9.
2012: Maria Negahdar; Pål R Njølstad; Oddmund Søvik; Ingvild Aukrust; Torgeir Flatmark; Bente B Johansson; Rohit N Kulkarni; Franz M Matschinsky; Janne Molnes; Anders Molven; Lise Bjørkhaug
GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation.
Biochimica et biophysica acta 2012;1822(11):1705-15.
2012: Nicolai M Doliba; Deborah Fenner; Ramakanth Sarabu; Bogumil Zelent; Joseph Bass; Franz M Matschinsky
Repair of diverse diabetic defects of β-cells in man and mouse by pharmacological glucokinase activation.
Diabetes, obesity & metabolism 2012;14 Suppl 3():109-19.
2012: Ramakanth Sarabu; Cheryl L Spence; Thomas Steele; John Tengi; Fred T Bizzarro; Wendy L Corbett; Mark T Dvorozniak; Lisa Garofalo; Wanping Geng; Joseph F Grippo; Kevin R Guertin; Nancy-Ellen Haynes; Darryl W Hilliard; Stanley Hutchings; Wang Ka; Marek M Kabat; Robert F Kester; Zhenmin Liang; Paige E Mahaney; Linda Marcus; Franz M Matschinsky; David Moore; Michael Pignatello; Lida Qi; Jagdish Racha; Roumen Radinov; Yi Ren; Joseph Grimsby
Discovery of piragliatin--first glucokinase activator studied in type 2 diabetic patients.
Journal of medicinal chemistry 2012;55(16):7021-36.
2012: Itzhak Nissim; Ilana Nissim; Suzanne L Wehrli; Marc Yudkoff; Yevgeny Daikhin; Oksana Horyn; Franz M Matschinsky
Effects of a glucokinase activator on hepatic intermediary metabolism: study with 13C-isotopomer-based metabolomics.
The Biochemical journal 2012;444(3):537-51.
2012: Bogumil Zelent; Carol Buettger; Joseph Grimsby; Ramakanth Sarabu; Jane M Vanderkooi; A Joshua Wand; Franz M Matschinsky
Thermal stability of glucokinase (GK) as influenced by the substrate glucose, an allosteric glucokinase activator drug (GKA) and the osmolytes glycerol and urea.
Biochimica et biophysica acta 2012;1824(5):769-84.
2011: Kirsty S Cullen; Franz M Matschinsky; Loranne Agius; Catherine Arden
Susceptibility of glucokinase-MODY mutants to inactivation by oxidative stress in pancreatic β-cells.
Diabetes 2011;60(12):3175-85.
2011: Bogumil Zelent; Dorothy K Zelent; Joseph Bass; Carol Buettger; Pan Chen; Deborah Fenner; Joseph Grimsby; Monique Laberge; Stella Odili; Ramakanth Sarabu; Charles Stanley; Jane M Vanderkooi; Franz M Matschinsky
Mutational analysis of allosteric activation and inhibition of glucokinase.
The Biochemical journal 2011;440(2):203-15.
2011: Deborah Fenner; Joseph Grimsby; Hee-Kyung Hong; Yumiko Kobayashi; Akira Kohsaka; Franz M Matschinsky; Stella Odili; Sandra M Siepka; Joseph S Takahashi; Martha Hotz Vitaterna; Bogumil Zelent; Pan Chen; Joseph Bass
Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators.
The Journal of biological chemistry 2011;286(45):39560-72.
2011: Changhong Li; Ming Li; Franz M Matschinsky; Srinivas Narayan; Michael J Bennett; Pan Chen; Charles A Stanley; Thomas J Smith
Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site.
The Journal of biological chemistry 2011;286(39):34164-74.
2011: Franz M Matschinsky; Bogumil Zelent; Nicolai M Doliba; Changhong Li; Jane M Vanderkooi; Ali Naji; Ramakanth Sarabu; Joseph Grimsby
Glucokinase activators for diabetes therapy: May 2010 status report.
Diabetes care 2011;34 Suppl 2():S236-43.
2011: Franz M Matschinsky; Bogumil Zelent; Nicolai M Doliba; Klaus kaestner; Jane M Vanderkooi; Joseph Grimsby; Steven J Berthel; Ramakanth Sarabu
Research and development of glucokinase activators for diabetes therapy: theoretical and practical aspects.
Handbook of experimental pharmacology 2011;(203):357-401.
2010: Changhong Li; Pan Chen; Andrew Palladino; Srinivas Narayan; Laurie K Russell; Samir Sayed; Guoxiang Xiong; Jie Chen; David Stokes; Yasmeen M Butt; Patricia M Jones; Heather W Collins; Noam A Cohen; Akiva S Cohen; Itzhak Nissim; Thomas J Smith; Arnold W Strauss; Franz M Matschinsky; Michael J Bennett; Charles A Stanley
Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase.
The Journal of biological chemistry 2010;285(41):31806-18.
2010: Nicolai M Doliba; Wei Qin; Sergei A Vinogradov; David F Wilson; Franz M Matschinsky
Palmitic acid acutely inhibits acetylcholine- but not GLP-1-stimulated insulin secretion in mouse pancreatic islets.
American journal of physiology. Endocrinology and metabolism 2010;299(3):E475-85.
2010: Nan Gao; John Le Lay; Wei Qin; Nicolai M Doliba; Jonathan Schug; Alan J Fox; Olga Smirnova; Franz M Matschinsky; Klaus kaestner
Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell.
Molecular endocrinology (Baltimore, Md.) 2010;24(8):1594-604.
2010: Nancy-Ellen Haynes; Wendy L Corbett; Fred T Bizzarro; Kevin R Guertin; Darryl W Hilliard; George W Holland; Robert F Kester; Paige E Mahaney; Lida Qi; Cheryl L Spence; John Tengi; Mark T Dvorozniak; Aruna Railkar; Franz M Matschinsky; Joseph F Grippo; Joseph Grimsby; Ramakanth Sarabu
Discovery, structure-activity relationships, pharmacokinetics, and efficacy of glucokinase activator (2R)-3-cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide (RO0281675).
Journal of medicinal chemistry 2010;53(9):3618-25.
2010: Antonio L Cuesta-Muñoz; Tiinamaija Tuomi; Nadia Cobo; Hanna Koskela; Stella Odili; Amanda Stride; Carol Buettger; Timo Otonkoski; philippe froguel; Joseph Grimsby; Maria Garcia-Gimeno; Franz M Matschinsky
Clinical heterogeneity in monogenic diabetes caused by mutations in the glucokinase gene (GCK-MODY).
Diabetes care 2010;33(2):290-2.
2010: Franz M Matschinsky; Daniel Porte
Glucokinase activators (GKAs) promise a new pharmacotherapy for diabetics.
F1000 medicine reports 2010;2():.
2009: Samir Sayed; David R Langdon; Stella Odili; Pan Chen; Carol Buettger; Alisa B Schiffman; Mariko Suchi; Rebecca Taub; Joseph Grimsby; Franz M Matschinsky; Charles A Stanley
Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism caused by glucokinase activating mutations.
Diabetes 2009;58(6):1419-27.
2009: Franz M Matschinsky
Assessing the potential of glucokinase activators in diabetes therapy.
Nature reviews. Drug discovery 2009;8(5):399-416.
2008: Diva D De León; Changhong Li; Madeleine I Delson; Franz M Matschinsky; Charles A Stanley; Doris A Stoffers
Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion.
The Journal of biological chemistry 2008;283(38):25786-93.
2008: Bogumil Zelent; Stella Odili; Carol Buettger; Chiyo Shiota; Joseph Grimsby; Rebecca Taub; Mark Magnuson; Jane M Vanderkooi; Franz M Matschinsky
Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence.
The Biochemical journal 2008;413(2):269-80.
2008: Changhong Li; Itzhak Nissim; Pan Chen; Carol Buettger; Habiba Najafi; Yevgeny Daikhin; Ilana Nissim; Heather W Collins; Marc Yudkoff; Charles A Stanley; Franz M Matschinsky
Elimination of KATP channels in mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gamma-aminobutyric acid shunt.
The Journal of biological chemistry 2008;283(25):17238-49.
2007: Yumi Imai; Hiralben R Patel; Evan J Hawkins; Nicolai M Doliba; Franz M Matschinsky; Rexford S Ahima
Insulin secretion is increased in pancreatic islets of neuropeptide Y-deficient mice.
Endocrinology 2007;148(12):5716-23.
2007: Nan Gao; Peter White; Nicolai M Doliba; Maria L Golson; Franz M Matschinsky; Klaus kaestner
Foxa2 controls vesicle docking and insulin secretion in mature Beta cells.
Cell metabolism 2007;6(4):267-79.
2007: Catherine Arden; Alison Trainer; Núria de la Iglesia; Kathleen T Scougall; Anna L Gloyn; Alex J Lange; James A M Shaw; Franz M Matschinsky; Loranne Agius
Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic beta-cells: evidence for cellular instability of catalytic activity.
Diabetes 2007;56(7):1773-82.
2007: Robert L Sorenson; Laurence E Stout; T Clark Brelje; Thomas L Jetton; Franz M Matschinsky
Immunohistochemical evidence for the presence of glucokinase in the gonadotropes and thyrotropes of the anterior pituitary gland of rat and monkey.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007;55(6):555-66.
2007: Nicolai M Doliba; Suzanne Wehrli; Marko Z Vatamaniuk; Wei Qin; Carol Buettger; Heather W Collins; Franz M Matschinsky
Metabolic and ionic coupling factors in amino acid-stimulated insulin release in pancreatic beta-HC9 cells.
American journal of physiology. Endocrinology and metabolism 2007;292(6):E1507-19.
2007: Maria F Pino; Kyoung-Ah Kim; Kathy D Shelton; Jill Lindner; Stella Odili; Changhong Li; Heather W Collins; Masakazu Shiota; Franz M Matschinsky; Mark Magnuson
Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.
The Journal of biological chemistry 2007;282(18):13906-16.
2007: Olga T Hardy; Hans E Hohmeier; Thomas C Becker; Elisabetta Manduchi; Nicolai M Doliba; Rana K Gupta; Peter White; Christian J Stoeckert; Franz M Matschinsky; Christopher B Newgard; Klaus kaestner
Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.
Molecular endocrinology (Baltimore, Md.) 2007;21(3):765-73.
2006: Marko Z Vatamaniuk; Rana K Gupta; Kristen A Lantz; Nicolai M Doliba; Franz M Matschinsky; Klaus kaestner
Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation.
Diabetes 2006;55(10):2730-6.
2006: Franz M Matschinsky
Nitrosative stress, uric acid, and peripheral nerve function in early type 1 diabetes. Diabetes 51:2817-2825.
Diabetes 2006;55(9):2664.
2006: Nicolai M Doliba; Wei Qin; Marko Z Vatamaniuk; Carol Buettger; Heather W Collins; Mark Magnuson; Klaus kaestner; David F Wilson; Richard D Carr; Franz M Matschinsky
Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets.
American journal of physiology. Endocrinology and metabolism 2006;291(3):E525-35.
2006: Dorothy Zelent; Maria L Golson; Brigitte Koeberlein; Roel Quintens; Leentje Van Lommel; Carol Buettger; Heather Weik-Collins; Rebecca Taub; Joseph Grimsby; Frans Schuit; Klaus kaestner; Franz M Matschinsky
A glucose sensor role for glucokinase in anterior pituitary cells.
Diabetes 2006;55(7):1923-9.
2006: Changhong Li; Andrea Matter; Andrea Kelly; Tom Petty; Habiba Najafi; Courtney MacMullen; Yevgeny Daikhin; Itzhak Nissim; Adam Lazarow; Jae Kwagh; Heather W Collins; Betty Y L Hsu; Itzhak Nissim; Marc Yudkoff; Franz M Matschinsky; Charles A Stanley
Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice.
The Journal of biological chemistry 2006;281(22):15064-72.
2006: Jørn V Sagen; Stella Odili; Lise Bjørkhaug; Dorothy Zelent; Carol Buettger; Jae Kwagh; Charles Stanley; Knut Dahl-Jørgensen; Carine de Beaufort; Graeme I Bell; Yi Han; Joseph Grimsby; Rebecca Taub; Anders Molven; Oddmund Søvik; Pål R Njølstad; Franz M Matschinsky
From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation.
Diabetes 2006;55(6):1713-22.
2006: Changhong Li; Aron Allen; Jae Kwagh; Nicolai M Doliba; Wei Qin; Habiba Najafi; Heather W Collins; Franz M Matschinsky; Charles A Stanley; Thomas J Smith
Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase.
The Journal of biological chemistry 2006;281(15):10214-21.
2006: Franz M Matschinsky; Mark Magnuson; Dorothy Zelent; Thomas L Jetton; Nicolai M Doliba; Yi Han; Rebecca Taub; Joseph Grimsby
The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy.
Diabetes 2006;55(1):1-12.
2005: Franz M Matschinsky
Glucokinase, glucose homeostasis, and diabetes mellitus.
Current diabetes reports 2005;5(3):171-6.
2005: Anna L Gloyn; Stella Odili; Dorothy Zelent; Carol Buettger; Harriet A J Castleden; Anna M Steele; Amanda Stride; Chiyo Shiota; Mark Magnuson; Renata Lorini; Giuseppe d'Annunzio; Charles A Stanley; Jae Kwagh; Emile Van Schaftingen; Maria Veiga-da-Cunha; Fabrizio Barbetti; Pete Dunten; Yi Han; Joseph Grimsby; Rebecca Taub; Sian Ellard; Andrew T Hattersley; Franz M Matschinsky
Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.
The Journal of biological chemistry 2005;280(14):14105-13.
2005: Rana K Gupta; Marko Z Vatamaniuk; Catherine S Lee; Reed C Flaschen; James T Fulmer; Franz M Matschinsky; Stephen A Duncan; Klaus kaestner
The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.
The Journal of clinical investigation 2005;115(4):1006-15.
2005: Dorothy Zelent; Habiba Najafi; Stella Odili; Carol Buettger; H Weik-Collins; Changhong Li; Nicolai M Doliba; Joseph Grimsby; Franz M Matschinsky
Glucokinase and glucose homeostasis: proven concepts and new ideas.
Biochemical Society transactions 2005;33(Pt 1):306-10.
2005: Gary P Kobinger; Shaoping Deng; Jean-Pierre Louboutin; Marko Z Vatamaniuk; Victor M Rivera; Moh-Moh Lian; James F Markmann; Tim Clackson; Steven E Raper; Franz M Matschinsky; James M Wilson
Pharmacologically regulated regeneration of functional human pancreatic islets.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(1):105-11.
2004: Kristen A Lantz; Marko Z Vatamaniuk; John E Brestelli; Joshua R Friedman; Franz M Matschinsky; Klaus kaestner
Foxa2 regulates multiple pathways of insulin secretion.
The Journal of clinical investigation 2004;114(4):512-20.
2004: A Schmitz; Chyng-Yann Shiue; Q Feng; Grace G Shiue; Shaoping Deng; Michael Pourdehnad; Ralf Schirrmacher; Marko Z Vatamaniuk; Nicolai M Doliba; Franz M Matschinsky; Bryan Wolf; Frank Rösch; Ali Naji; Abass Alavi
Synthesis and evaluation of fluorine-18 labeled glyburide analogs as beta-cell imaging agents.
Nuclear medicine and biology 2004;31(4):483-91.
2004: Nicolai M Doliba; Wei Qin; Marko Z Vatamaniuk; Changhong Li; Dorothy Zelent; Habiba Najafi; Carol Buettger; Heather W Collins; Richard D Carr; Mark Magnuson; Franz M Matschinsky
Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine.
American journal of physiology. Endocrinology and metabolism 2004;286(5):E834-43.
2004: Changhong Li; Carol Buettger; Jae Kwagh; Andrea Matter; Yevgeny Daikhin; Itzhak Nissim; Heather W Collins; Marc Yudkoff; Charles A Stanley; Franz M Matschinsky
A signaling role of glutamine in insulin secretion.
The Journal of biological chemistry 2004;279(14):13393-401.
2004: Shaoping Deng; Marko Z Vatamaniuk; Xiaolun Huang; Nicolai M Doliba; Moh-Moh Lian; Adam Frank; H ERGUN VELIDEDEOGLU; Niraj Desai; Brigitte Koeberlein; Bryan Wolf; Clyde F Barker; Ali Naji; Franz M Matschinsky; James F Markmann
Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects.
Diabetes 2004;53(3):624-32.
2004: Gary P Kobinger; Shaoping Deng; Jean-Pierre Louboutin; Marko Z Vatamaniuk; Franz M Matschinsky; James F Markmann; Steven E Raper; James M Wilson
Transduction of human islets with pseudotyped lentiviral vectors.
Human gene therapy 2004;15(2):211-9.
2003: Pål R Njølstad; Jørn V Sagen; Lise Bjørkhaug; Stella Odili; Naim Shehadeh; Doua Bakry; S.Umit Sarici; Faruk Alpay; Janne Molnes; Anders Molven; Oddmund Søvik; Franz M Matschinsky
Permanent neonatal diabetes caused by glucokinase deficiency: inborn error of the glucose-insulin signaling pathway.
Diabetes 2003;52(11):2854-60.
2003: Ewan Bell; Xiaopei Cao; Jacob A Moibi; Scott R Greene; Robert Young; Matteo Trucco; Zhiyong Gao; Franz M Matschinsky; Shaoping Deng; James F Markman; Ali Naji; Bryan A Wolf
Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets.
Diabetes 2003;52(11):2731-9.
2003: Anna L Gloyn; Kees Noordam; Michèl A A P Willemsen; Sian Ellard; Wayne W K Lam; Ian W Campbell; Paula Midgley; Chiyo Shiota; Carol Buettger; Mark Magnuson; Franz M Matschinsky; Andrew T Hattersley
Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations.
Diabetes 2003;52(9):2433-40.
2003: Joseph Grimsby; Ramakanth Sarabu; Wendy L Corbett; Nancy-Ellen Haynes; Fred T Bizzarro; John W Coffey; Kevin R Guertin; Darryl W Hilliard; Robert F Kester; Paige E Mahaney; Linda Marcus; Lida Qi; Cheryl L Spence; John Tengi; Mark Magnuson; Chang An Chu; Mark T Dvorozniak; Franz M Matschinsky; Joseph F Grippo
Allosteric activators of glucokinase: potential role in diabetes therapy.
Science (New York, N.Y.) 2003;301(5631):370-3.
2003: James F Markmann; Shaoping Deng; Xiaolun Huang; Niraj Desai; H ERGUN VELIDEDEOGLU; Chengyang Lui; Adam Frank; Eileen Markmann; Maral Palanjian; Kenneth L Brayman; Bryan Wolf; Ewan Bell; Marko Vitamaniuk; Nicolai M Doliba; Franz M Matschinsky; Clyde F Barker; Ali Naji
Insulin independence following isolated islet transplantation and single islet infusions.
Annals of surgery 2003;237(6):741-9; discussion 749-50.
2003: James F Markmann; Shaoping Deng; Niraj Desai; Xiaolun Huang; H ERGUN VELIDEDEOGLU; Adam Frank; Chengyang Liu; Kenneth L Brayman; Moh-Moh Lian; Bryan Wolf; Ewan Bell; Marko Vitamaniuk; Nicolai M Doliba; Franz M Matschinsky; Eileen Markmann; Clyde F Barker; Ali Naji
The use of non-heart-beating donors for isolated pancreatic islet transplantation.
Transplantation 2003;75(9):1423-9.
2003: Zhiyong Gao; Robert A Young; Guizhu Li; Habiba Najafi; Carol Buettger; Siam S Sukumvanich; Ryan K Wong; Bryan A Wolf; Franz M Matschinsky
Distinguishing features of leucine and alpha-ketoisocaproate sensing in pancreatic beta-cells.
Endocrinology 2003;144(5):1949-57.
2003: Shaoping Deng; Marko Z Vatamaniuk; Moh-Moh Lian; Nicolai M Doliba; Jing Wang; Ewan Bell; Bryan Wolf; Steven E Raper; Franz M Matschinsky; James F Markmann
Insulin gene transfer enhances the function of human islet grafts.
Diabetologia 2003;46(3):386-93.
2003: Nicolai M Doliba; Marko Z Vatamaniuk; Carol Buettger; Wei Qin; Heather W Collins; Suzanne Wehrli; Richard D Carr; Franz M Matschinsky
Differential effects of glucose and glyburide on energetics and Na+ levels of betaHC9 cells: nuclear magnetic resonance spectroscopy and respirometry studies.
Diabetes 2003;52(2):394-402.
2003: Changhong Li; Habiba Najafi; Yevgeny Daikhin; Itzhak Nissim; Heather W Collins; Marc Yudkoff; Franz M Matschinsky; Charles A Stanley
Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets.
The Journal of biological chemistry 2003;278(5):2853-8.
2002: Andrea Kelly; Changhong Li; Zhiyong Gao; Charles A Stanley; Franz M Matschinsky
Glutaminolysis and insulin secretion: from bedside to bench and back.
Diabetes 2002;51 Suppl 3():S421-6.
2002: Franz M Matschinsky
Regulation of pancreatic beta-cell glucokinase: from basics to therapeutics.
Diabetes 2002;51 Suppl 3():S394-404.
2002: Zhiyong Gao; Robert A Young; Matteo M Trucco; Scott R Greene; Erik L Hewlett; Franz M Matschinsky; Bryan A Wolf
Protein kinase A translocation and insulin secretion in pancreatic beta-cells: studies with adenylate cyclase toxin from Bordetella pertussis.
The Biochemical journal 2002;368(Pt 2):397-404.
2002: Catherine S Lee; Newman J Sund; Marko Z Vatamaniuk; Franz M Matschinsky; Doris A Stoffers; Klaus kaestner
Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo.
Diabetes 2002;51(8):2546-51.
2002: Henrik Christesen; Bendt Brock Jacobsen; Stella Odili; Carol Buettger; Antonio Cuesta Muñoz; Torben Hansen; Klaus Brusgaard; Ornella Massa; Mark Magnuson; Chiyo Shiota; Franz M Matschinsky; Fabrizio Barbetti
The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy.
Diabetes 2002;51(4):1240-6.
2001: Ornella Massa; Franco Meschi; Antonio Cuesta Muñoz; A Caumo; Franco Cerutti; Sonia Toni; Valentino Cherubini; laura Guazzarotti; N Sulli; Franz M Matschinsky; Renata Lorini; Dario Iafusco; Fabrizio Barbetti
High prevalence of glucokinase mutations in Italian children with MODY. Influence on glucose tolerance, first-phase insulin response, insulin sensitivity and BMI. Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetes (SIEDP).
Diabetologia 2001;44(7):898-905.
2001: Newman J Sund; Marko Z Vatamaniuk; M Casey; S L Ang; Mark Magnuson; Doris A Stoffers; Franz M Matschinsky; Klaus kaestner
Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia.
Genes & development 2001;15(13):1706-15.
2001: Pål R Njølstad; Oddmund Søvik; A Cuesta-Muñoz; Lise Bjørkhaug; Ornella Massa; Fabrizio Barbetti; DAG UNDLIEN; Chiyo Shiota; Mark Magnuson; Anders Molven; Franz M Matschinsky; Graeme I Bell
Neonatal diabetes mellitus due to complete glucokinase deficiency.
The New England journal of medicine 2001;344(21):1588-92.
2000: Joseph Grimsby; John W Coffey; M T Dvorozniak; J Magram; G Li; Franz M Matschinsky; Chiyo Shiota; S Kaur; Mark Magnuson; Joseph F Grippo
Characterization of glucokinase regulatory protein-deficient mice.
The Journal of biological chemistry 2000;275(11):7826-31.
1999: E A Davis; A Cuesta-Muñoz; M Raoul; Carol Buettger; IR Sweet; M Moates; Mark Magnuson; Franz M Matschinsky
Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis.
Diabetologia 1999;42(10):1175-86.
1999: Bhuvaneshwari Mahalingam; Antonio Cuesta Muñoz; E A Davis; Franz M Matschinsky; Robert W Harrison; Irene T Weber
Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia.
Diabetes 1999;48(9):1698-705.
1999: CV Burke; Carol Buettger; E A Davis; Steven J McClane; Franz M Matschinsky; Steven E Raper
Cell-biological assessment of human glucokinase mutants causing maturity-onset diabetes of the young type 2 (MODY-2) or glucokinase-linked hyperinsulinaemia (GK-HI).
The Biochemical journal 1999;342 ( Pt 2)():345-52.
1999: ZY Gao; Guizhu Li; Habiba Najafi; Bryan A Wolf; Franz M Matschinsky
Glucose regulation of glutaminolysis and its role in insulin secretion.
Diabetes 1999;48(8):1535-42.
1998: ZY Gao; M Chen; Heather W Collins; Franz M Matschinsky; Virginia M-Y Lee; Bryan A Wolf
Mechanisms of spontaneous cytosolic Ca2+ transients in differentiated human neuronal cells.
The European journal of neuroscience 1998;10(7):2416-25.
1998: ZY Gao; G Xu; Magdalena M Stwora-Wojczyk; Franz M Matschinsky; Virginia M-Y Lee; Bryan A Wolf
Retinoic acid induction of calcium channel expression in human NT2N neurons.
Biochemical and biophysical research communications 1998;247(2):407-13.
1998: ZY Gao; Heather W Collins; Franz M Matschinsky; Virginia M-Y Lee; Bryan A Wolf
Cytotoxic effect of beta-amyloid on a human differentiated neuron is not mediated by cytoplasmic Ca2+ accumulation.
Journal of neurochemistry 1998;70(4):1394-400.
1998: Franz M Matschinsky; Benjamin Glaser; Mark Magnuson
Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.
Diabetes 1998;47(3):307-15.
1998: Benjamin Glaser; P Kesavan; M Heyman; E Davis; A Cuesta; Adina Buchs; Charles A Stanley; Paul S Thornton; M Alan Permutt; Franz M Matschinsky; KC Herold
Familial hyperinsulinism caused by an activating glucokinase mutation.
The New England journal of medicine 1998;338(4):226-30.
1997: Y Liang; Carol Buettger; D K Berner; Franz M Matschinsky
Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (beta HC9).
Diabetologia 1997;40(9):1018-27.
1997: Y Liang; S M Cushman; R R Whitesell; Franz M Matschinsky
GLUT1 is adequate for glucose uptake in GLUT2-deficient insulin-releasing beta-cells.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1997;29(6):255-60.
1997: Franz M Matschinsky; Heather W Collins
Essential biochemical design features of the fuel-sensing system in pancreatic beta-cells.
Chemistry & biology 1997;4(4):249-57.
1997: IR Sweet; Habiba Najafi; Guizhu Li; J Grodberg; Franz M Matschinsky
Measurement and modeling of glucose-6-phosphatase in pancreatic islets.
The American journal of physiology 1997;272(4 Pt 1):E696-711.
1997: P Kesavan; L Wang; E Davis; A Cuesta; IR Sweet; K Niswender; Mark Magnuson; Franz M Matschinsky
Structural instability of mutant beta-cell glucokinase: implications for the molecular pathogenesis of maturity-onset diabetes of the young (type-2).
The Biochemical journal 1997;322 ( Pt 1)():57-63.
1997: IR Sweet; Franz M Matschinsky
Are there kinetic advantages of GLUT2 in pancreatic glucose sensing?
Diabetologia 1997;40(1):112-9.
1996: IR Sweet; G Li; Habiba Najafi; D Berner; Franz M Matschinsky
Effect of a glucokinase inhibitor on energy production and insulin release in pancreatic islets.
The American journal of physiology 1996;271(3 Pt 1):E606-25.
1996: Z Gao; R J Konrad; H Collins; Franz M Matschinsky; P L Rothenberg; Bryan A Wolf
Wortmannin inhibits insulin secretion in pancreatic islets and beta-TC3 cells independent of its inhibition of phosphatidylinositol 3-kinase.
Diabetes 1996;45(7):854-62.
1996: Y Liang; Guang Bai; Nicolai M Doliba; Carol Buettger; L Wang; D K Berner; Franz M Matschinsky
Glucose metabolism and insulin release in mouse beta HC9 cells, as model for wild-type pancreatic beta-cells.
The American journal of physiology 1996;270(5 Pt 1):E846-57.
1996: Franz M Matschinsky
Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm.
Diabetes 1996;45(2):223-41.
1995: C Z Shi; R N Dhir; P Kesavan; S L Zhang; Franz M Matschinsky; S Heyner
Mouse embryonic stem cells express receptors of the insulin family of growth factors.
Molecular reproduction and development 1995;42(2):173-9.
1995: Y Liang; P Kesavan; L Q Wang; Kevin D Niswender; Y Tanizawa; M Alan Permutt; Mark Magnuson; Franz M Matschinsky
Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme.
The Biochemical journal 1995;309 ( Pt 1)():167-73.
1995: IR Sweet; Franz M Matschinsky
Mathematical model of beta-cell glucose metabolism and insulin release. I. Glucokinase as glucosensor hypothesis.
The American journal of physiology 1995;268(4 Pt 1):E775-88.
1994: Y Liang; Thomas L Jetton; E C Zimmerman; Habiba Najafi; D K Berner; Franz M Matschinsky; Mark Magnuson
Effects of glucose on insulin secretion, glucokinase activity, and transgene expression in transgenic mouse islets containing an upstream glucokinase promoter-human growth hormone fusion gene.
Diabetes 1994;43(9):1138-45.
1994: Y Liang; S Bonner-Weir; Y J Wu; C D Berdanier; D K Berner; S Efrat; Franz M Matschinsky
In situ glucose uptake and glucokinase activity of pancreatic islets in diabetic and obese rodents.
The Journal of clinical investigation 1994;93(6):2473-81.
1994: C Z Shi; Heather W Collins; Carol Buettger; WT Garside; Franz M Matschinsky; S Heyner
Insulin family growth factors have specific effects on protein synthesis in preimplantation mouse embryos.
Molecular reproduction and development 1994;37(4):398-406.
1994: Thomas L Jetton; Y Liang; C C Pettepher; E C Zimmerman; F G Cox; K Horvath; Franz M Matschinsky; Mark Magnuson
Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut.
The Journal of biological chemistry 1994;269(5):3641-54.
1994: C Z Shi; Heather W Collins; WT Garside; Carol Buettger; Franz M Matschinsky; S Heyner
Protein databases for compacted eight-cell and blastocyst-stage mouse embryos.
Molecular reproduction and development 1994;37(1):34-47.
1993: P Ronner; Franz M Matschinsky; T L Hang; A J Epstein; Carol Buettger
Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells.
Diabetes 1993;42(12):1760-72.
1993: Franz M Matschinsky; Y Liang; P Kesavan; L Wang; P Froguel; G Velho; D Cohen; M Alan Permutt; Y Tanizawa; Thomas L Jetton
Glucokinase as pancreatic beta cell glucose sensor and diabetes gene.
The Journal of clinical investigation 1993;92(5):2092-8.
1992: Y Liang; Habiba Najafi; R M Smith; E C Zimmerman; Mark Magnuson; M Tal; Franz M Matschinsky
Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture.
Diabetes 1992;41(7):792-806.
1992: John C Oberholtzer; Carol Buettger; M C Summers; Franz M Matschinsky
Metabolic labelling and quantitation of proteins synthesized by single chick cochleas.
Hearing research 1992;60(1):103-9.
1992: H Collins; Habiba Najafi; Carol Buettger; J Rombeau; R G Settle; Franz M Matschinsky
Identification of glucose response proteins in two biological models of beta-cell adaptation to chronic high glucose exposure.
The Journal of biological chemistry 1992;267(2):1357-66.
1991: A Ghosh; P Ronner; E Cheong; P Khalid; Franz M Matschinsky
The role of ATP and free ADP in metabolic coupling during fuel-stimulated insulin release from islet beta-cells in the isolated perfused rat pancreas.
The Journal of biological chemistry 1991;266(34):22887-92.
1991: K G Lurie; A Loy; J Dutton; Franz M Matschinsky
Measurement of extracellular space in the rabbit AV node.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1991;39(12):1671-7.
1991: P Ronner; E Cheong; P Khalid; R W Tuman; Franz M Matschinsky
Effect of linogliride on hormone release from perfused rat pancreas. Fuel dependence and desensitization by tolbutamide.
Diabetes 1991;40(7):878-84.
1991: Y Liang; Thomas L Jetton; E C Zimmerman; Habiba Najafi; Franz M Matschinsky; Mark Magnuson
Effects of alternate RNA splicing on glucokinase isoform activities in the pancreatic islet, liver, and pituitary.
The Journal of biological chemistry 1991;266(11):6999-7007.
1991: Y Liang; Franz M Matschinsky
Content of CoA-esters in perifused rat islets stimulated by glucose and other fuels.
Diabetes 1991;40(3):327-33.
1991: J W Starnes; E Cheong; Franz M Matschinsky
Hormone secretion by isolated perfused pancreas of aging Fischer 344 rats.
The American journal of physiology 1991;260(1 Pt 1):E59-66.
1990: Y Liang; Habiba Najafi; Franz M Matschinsky
Glucose regulates glucokinase activity in cultured islets from rat pancreas.
The Journal of biological chemistry 1990;265(28):16863-6.
1990: A Loy; K G Lurie; A Ghosh; J M Wilson; L C MacGregor; Franz M Matschinsky
Diabetes and the myo-inositol paradox.
Diabetes 1990;39(10):1305-12.
1990: Heather W Collins; Carol Buettger; Franz M Matschinsky
High-resolution two-dimensional polyacrylamide gel electrophoresis reveals a glucose-response protein of 65 kDa in pancreatic islet cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(14):5494-8.
1990: Franz M Matschinsky
Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes.
Diabetes 1990;39(6):647-52.
1989: Barbara E Corkey; M C Glennon; K S Chen; Jude T Deeney; Franz M Matschinsky; Marc Prentki
A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells.
The Journal of biological chemistry 1989;264(36):21608-12.
1989: Jean-Francois H Geschwind; Marcia Hiriart; M C Glennon; Habiba Najafi; Barbara E Corkey; Franz M Matschinsky; Marc Prentki
Selective activation of Ca2+ influx by extracellular ATP in a pancreatic beta-cell line (HIT).
Biochimica et biophysica acta 1989;1012(1):107-15.
1988: T Shimizu; J C Parker; Habiba Najafi; Franz M Matschinsky
Control of glucose metabolism in pancreatic beta-cells by glucokinase, hexokinase, and phosphofructokinase. Model study with cell lines derived from beta-cells.
Diabetes 1988;37(11):1524-30.
1988: Marc Prentki; M C Glennon; A P Thomas; R L Morris; Franz M Matschinsky; Barbara E Corkey
Cell-specific patterns of oscillating free Ca2+ in carbamylcholine-stimulated insulinoma cells.
The Journal of biological chemistry 1988;263(23):11044-7.
1988: I Sussman; Franz M Matschinsky
Diabetes affects sorbitol and myo-inositol levels of neuroectodermal tissue during embryogenesis in rat.
Diabetes 1988;37(7):974-81.
1988: T Shimizu; Franz M Matschinsky
Characteristics of glucokinase of the Kirkman insulinoma.
Metabolism: clinical and experimental 1988;37(7):631-4.
1988: John C Oberholtzer; Carol Buettger; M C Summers; Franz M Matschinsky
The 28-kDa calbindin-D is a major calcium-binding protein in the basilar papilla of the chick.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(10):3387-90.
1988: T Shimizu; B B Knowles; Franz M Matschinsky
Control of glucose phosphorylation and glucose usage in clonal insulinoma cells.
Diabetes 1988;37(5):563-8.
1988: Barbara E Corkey; Keith Tornheim; Jude T Deeney; M C Glennon; J C Parker; Franz M Matschinsky; Neil B Ruderman; Marc Prentki
Linked oscillations of free Ca2+ and the ATP/ADP ratio in permeabilized RINm5F insulinoma cells supplemented with a glycolyzing cell-free muscle extract.
The Journal of biological chemistry 1988;263(9):4254-8.
1988: Barbara E Corkey; Jude T Deeney; M C Glennon; Franz M Matschinsky; Marc Prentki
Regulation of steady-state free Ca2+ levels by the ATP/ADP ratio and orthophosphate in permeabilized RINm5F insulinoma cells.
The Journal of biological chemistry 1988;263(9):4247-53.
1988: I P Sussman; L C MacGregor; B R Masters; Franz M Matschinsky
Quantitative histochemical determination of Na+ and K+ in microscopic samples using carbon furnace atomic absorption spectrometry.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1988;36(3):237-44.
1987: M E Schneider; Douglas Cotanche; D M Fambrough; James C Saunders; Franz M Matschinsky
Immunocytochemical and quantitative studies of Na+,K+-ATPase distribution in the developing chick cochlea.
Hearing research 1987;31(1):39-53.
1987: Marc Prentki; Franz M Matschinsky
Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion.
Physiological reviews 1987;67(4):1185-248.
1987: Marc Prentki; M C Glennon; Jean-Francois H Geschwind; Franz M Matschinsky; Barbara E Corkey
Cyclic AMP raises cytosolic Ca2+ and promotes Ca2+ influx in a clonal pancreatic beta-cell line (HIT T-15).
FEBS letters 1987;220(1):103-7.
1987: M D Meglasson; C D Manning; Habiba Najafi; Franz M Matschinsky
Fuel-stimulated insulin secretion by clonal hamster beta-cell line HIT T-15.
Diabetes 1987;36(4):477-84.
1986: M D Meglasson; C D Manning; Habiba Najafi; Franz M Matschinsky
Glucose transport by radiation-induced insulinoma and clonal pancreatic beta-cells.
Diabetes 1986;35(12):1340-4.
1986: Franz M Matschinsky; A K Ghosh; M D Meglasson; M Prentki; V June; D von Allman
Metabolic concomitants in pure, pancreatic beta cells during glucose-stimulated insulin secretion.
The Journal of biological chemistry 1986;261(30):14057-61.
1986: M D Meglasson; P T Burch; D K Berner; Habiba Najafi; Franz M Matschinsky
Identification of glucokinase as an alloxan-sensitive glucose sensor of the pancreatic beta-cell.
Diabetes 1986;35(10):1163-73.
1986: Marc Prentki; Jude T Deeney; Franz M Matschinsky; S K Joseph
Neomycin: a specific drug to study the inositol-phospholipid signalling system?
FEBS letters 1986;197(1-2):285-8.
1986: John C Oberholtzer; M E Schneider; M C Summers; James C Saunders; Franz M Matschinsky
The developmental appearance of a major basilar papilla-specific protein in the chick.
Hearing research 1986;23(2):161-8.
1986: Franz M Matschinsky; M Meglasson; A Ghosh; M Appel; F Bedoya; Marc Prentki; B Corkey; T Shimizu; D Berner; Habiba Najafi
Biochemical design features of the pancreatic islet cell glucose-sensory system.
Advances in experimental medicine and biology 1986;211():459-69.
1985: P T Burch; D K Berner; Habiba Najafi; M D Meglasson; Franz M Matschinsky
Regulatory role of fructose-2,6-bisphosphate in pancreatic islet glucose metabolism remains unsettled.
Diabetes 1985;34(10):1014-8.
1984: P T Burch; D K Berner; A Leontire; A Vogin; B M Matschinsky; Franz M Matschinsky
Metabolic adaption of pancreatic islet tissue in aging rats.
Journal of gerontology 1984;39(1):2-6.
1983: M D Meglasson; P T Burch; M Hoenig; W L Chick; Franz M Matschinsky
Identification and significance of glucokinase in transplantable insulinomas.
The Journal of biological chemistry 1983;258(4):2094-7.
1983: M D Meglasson; P T Burch; D K Berner; Habiba Najafi; A P Vogin; Franz M Matschinsky
Chromatographic resolution and kinetic characterization of glucokinase from islets of Langerhans.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(1):85-9.
1981: P T Burch; M D Trus; D K Berner; A Leontire; K C Zawalich; Franz M Matschinsky
Adaptation of glycolytic enzymes: glucose use and insulin release in rat pancreatic islets during fasting and refeeding.
Diabetes 1981;30(11):923-8.
1981: Michael Trus; W S Zawalich; P T Burch; D K Berner; V A Weill; Franz M Matschinsky
Regulation of glucose metabolism in pancreatic islets.
Diabetes 1981;30(11):911-22.