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Luciano Adorini

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Rachel H McMahan; Mark Pruzanski; Maxwell Smith; Xiaoxin X Wang; Luciano Adorini; Lin Ling Cheng; Karim El Kasmi; Lucy Golden-Mason; Tibor Krisko; Moshe Levi; Hugo R Rosen
Bile Acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic Fatty liver disease.
Annamaria Morelli; Erica Sarchielli; Gabriella B Vannelli; Linda Vignozzi; Ravit Yehiely-Cohen; Luciano Adorini; Marco Carini; Ilaria Cellai; Paolo Comeglio; Sandra Filippi; Mauro Gacci; Elena Maneschi; Mario Maggi
Testosterone and farnesoid X receptor agonist INT-747 counteract high fat diet-induced bladder alterations in a rabbit model of metabolic syndrome.
Luciano Adorini; Mark Pruzanski; David Shapiro
Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis.

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2013: Rachel H McMahan; Mark Pruzanski; Maxwell Smith; Xiaoxin X Wang; Luciano Adorini; Lin Ling Cheng; Karim El Kasmi; Lucy Golden-Mason; Tibor Krisko; Moshe Levi; Hugo R Rosen
Bile Acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic Fatty liver disease.
The Journal of biological chemistry 2013;288(17):11761-70.
2012: Annamaria Morelli; Erica Sarchielli; Gabriella B Vannelli; Linda Vignozzi; Ravit Yehiely-Cohen; Luciano Adorini; Marco Carini; Ilaria Cellai; Paolo Comeglio; Sandra Filippi; Mauro Gacci; Elena Maneschi; Mario Maggi
Testosterone and farnesoid X receptor agonist INT-747 counteract high fat diet-induced bladder alterations in a rabbit model of metabolic syndrome.
The Journal of steroid biochemistry and molecular biology 2012;132(1-2):80-92.
2012: Luciano Adorini; Mark Pruzanski; David Shapiro
Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis.
Drug discovery today 2012;17(17-18):988-97.
2012: Linda Vignozzi; Annamaria Morelli; Gabriella Nesi; Marie-Pierre Piccinni; Raffaella Santi; Luciano Adorini; Marco Carini; Ilaria Cellai; Paolo Comeglio; Sandra Filippi; Mauro Gacci; Federica Logiodice; Letizia Lombardelli; Mario Maggi
Antiinflammatory effect of androgen receptor activation in human benign prostatic hyperplasia cells.
The Journal of endocrinology 2012;214(1):31-43.
2012: Maura Marinozzi; Benedetto Natalini; Daniela Passeri; Luciano Adorini; Andrea Carotti; Francesca De Franco; Antonio Macchiarulo; Mark Pruzanski; Giovanni Rizzo; Emiliano Rosatelli; Emanuele Sansone; Roccaldo Sardella; Roberto Pellicciari
Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists.
Bioorganic & medicinal chemistry 2012;20(11):3429-45.
2011: Francesco Lotti; M Mancini; I Noci; Luciano Adorini; Elisabetta Baldi; Giovanni Maria Colpi; Giovanni Corona; S Degli Innocenti; Erminio Filimberti; Gianni Forti; Mario Maggi
Ultrasonographic and clinical correlates of seminal plasma interleukin-8 levels in patients attending an andrology clinic for infertility.
International journal of andrology 2011;34(6 Pt 1):600-13.
2011: Anna Baghdasaryan; Thierry Claudel; Peter Fickert; Frank J Gonzalez; Judith Gumhold; Aldo Roda; Kristina Schoonjans; Dagmar Silbert; Mario Strazzabosco; Luciano Adorini; Stefania Vecchiotti; Michael Trauner
Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output.
Hepatology (Baltimore, Md.) 2011;54(4):1303-12.
2011: Annamaria Morelli; Linda Vignozzi; Mario Maggi; Luciano Adorini
Farnesoid X receptor activation improves erectile dysfunction in models of metabolic syndrome and diabetes.
Biochimica et biophysica acta 2011;1812(8):859-66.
2011: Antimo Gioiello; Antonio Macchiarulo; Andrea Carotti; Paolo Filipponi; Gabriele Costantino; Giovanni Rizzo; Luciano Adorini; Roberto Pellicciari
Extending SAR of bile acids as FXR ligands: discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine.
Bioorganic & medicinal chemistry 2011;19(8):2650-8.
2011: Raffaella M Gadaleta; Karel J van Erpecum; Bas Oldenburg; Ellen C L Willemsen; Willem Renooij; Stefania Murzilli; Leo W J Klomp; Peter D Siersema; Marguerite E I Schipper; Silvio Danese; Giuseppe Penna; Gilles Laverny; Luciano Adorini; Antonio Moschetta; Saskia W C van Mil
Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease.
Gut 2011;60(4):463-72.
2011: Maurizio Cutolo; M Plebani; Yehuda Shoenfeld; Luciano Adorini; Angela Tincani
Vitamin D endocrine system and the immune response in rheumatic diseases.
Vitamins and hormones 2011;86():327-51.
2011: Linda Vignozzi; Annamaria Morelli; Sandra Filippi; Paolo Comeglio; Aravinda K Chavalmane; Matilde Marchetta; Mariateresa Toce; Ravit Yehiely-Cohen; Gabriella Barbara Vannelli; Luciano Adorini; Mario Maggi
Farnesoid X receptor activation improves erectile function in animal models of metabolic syndrome and diabetes.
The journal of sexual medicine 2011;8(1):57-77.
2010: Xiaoxin X Wang; Tao Jiang; Yan Shen; Yupanqui Caldas; Shinobu Miyazaki-Anzai; Hannah Santamaria; Cydney Urbanek; Nathaniel Solis; Pnina Scherzer; Linda Lewis; Frank J Gonzalez; Luciano Adorini; Mark Pruzanski; Jeffrey B Kopp; Jill W Verlander; Moshe Levi
Diabetic nephropathy is accelerated by farnesoid X receptor deficiency and inhibited by farnesoid X receptor activation in a type 1 diabetes model.
Diabetes 2010;59(11):2916-27.
2010: P Comeglio; A K Chavalmane; B Fibbi; Sandra Filippi; Matilde Marchetta; M Marini; Annamaria Morelli; Giuseppe Penna; L Vignozzi; Gabriella Barbara Vannelli; Luciano Adorini; Mario Maggi
Human prostatic urethra expresses vitamin D receptor and responds to vitamin D receptor ligation.
Journal of endocrinological investigation 2010;33(10):730-8.
2010: Silvano Sozzani; Massimo Locati; Angelo Vacca; Luciano Adorini; Gianpietro Semenzato
The Italian Society of Immunology: past, present and future.
European journal of immunology 2010;40(10):2664-6.
2010: Giovanni Rizzo; Daniela Passeri; Francesca De Franco; Gianmario Ciaccioli; Loredana Donadio; Giorgia Rizzo; Stefano Orlandi; Bahman Sadeghpour; Xiaoxin X Wang; Tao Jiang; Moshe Levi; Mark Pruzanski; Luciano Adorini
Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist.
Molecular pharmacology 2010;78(4):617-30.
2010: Costanza Sagrinati; Mariangela Sottili; Benedetta Mazzinghi; Elisa Borgogni; Luciano Adorini; Mario Serio; Paola Romagnani; Clara Crescioli
Comparison between VDR analogs and current immunosuppressive drugs in relation to CXCL10 secretion by human renal tubular cells.
Transplant international : official journal of the European Society for Organ Transplantation 2010;23(9):914-23.
2010: Gilles Laverny; Giuseppe Penna; Stefania Vetrano; Carmen Correale; Manuela Nebuloni; Silvio Danese; Luciano Adorini
Efficacy of a potent and safe vitamin D receptor agonist for the treatment of inflammatory bowel disease.
Immunology letters 2010;131(1):49-58.
2010: Benedetta Fibbi; Giuseppe Penna; Annamaria Morelli; Luciano Adorini; Mario Maggi
Chronic inflammation in the pathogenesis of benign prostatic hyperplasia.
International journal of andrology 2010;33(3):475-88.
2010: Luciano Adorini; Giuseppe Penna; Benedetta Fibbi; Mario Maggi
Vitamin D receptor agonists target static, dynamic, and inflammatory components of benign prostatic hyperplasia.
Annals of the New York Academy of Sciences 2010;1193():146-52.
2009: Xiaoxin X Wang; Tao Jiang; Yan Shen; Luciano Adorini; Mark Pruzanski; Frank J Gonzalez; Pnina Scherzer; Linda Lewis; Shinobu Miyazaki-Anzai; Moshe Levi
The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria.
American journal of physiology. Renal physiology 2009;297(6):F1587-96.
2009: Giuseppe Penna; Benedetta Fibbi; Mario Maggi; Luciano Adorini
Prostate autoimmunity: from experimental models to clinical counterparts.
Expert review of clinical immunology 2009;5(5):577-86.
2009: Luciano Adorini
Vitamin D receptor polymorphisms in primary biliary cirrhosis: a functional connection?
Journal of hepatology 2009;50(6):1071-3.
2009: Luciano Adorini; Giuseppe Penna
Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists.
Human immunology 2009;70(5):345-52.
2009: Gilles Laverny; Giuseppe Penna; Milan Uskokovic; Stanislaw Marczak; Hubert Maehr; Pawel Jankowski; Caroline Ceailles; Paul Vouros; Brenden Smith; Matthew Robinson; G Satyanarayana Reddy; Luciano Adorini
Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3.
Journal of medicinal chemistry 2009;52(8):2204-13.
2009: Jun Tang; Ru Zhou; Dror Luger; Wei Zhu; Phyllis B Silver; Rafael S Grajewski; Shao-Bo Su; Chi-Chao Chan; Luciano Adorini; Rachel R Caspi
Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):4624-32.
2009: Giuseppe Penna; Benedetta Fibbi; Susana Amuchastegui; Chiara Cossetti; Francesca Aquilano; Gilles Laverny; Mauro Gacci; Clara Crescioli; Mario Maggi; Luciano Adorini
Human benign prostatic hyperplasia stromal cells as inducers and targets of chronic immuno-mediated inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4056-64.
2009: Giuseppe Penna; Benedetta Fibbi; Susana Amuchastegui; Elisa Corsiero; Gilles Laverny; Enrico Silvestrini; Aravinda Chavalmane; Annamaria Morelli; Erica Sarchielli; Gabriella Barbara Vannelli; Mauro Gacci; Enrico Colli; Mario Maggi; Luciano Adorini
The vitamin D receptor agonist elocalcitol inhibits IL-8-dependent benign prostatic hyperplasia stromal cell proliferation and inflammatory response by targeting the RhoA/Rho kinase and NF-kappaB pathways.
The Prostate 2009;69(5):480-93.
2009: Luciano Adorini; Giuseppe Penna
Induction of tolerogenic dendritic cells by vitamin D receptor agonists.
Handbook of experimental pharmacology 2009;(188):251-73.
2008: Hong Jin Lee; Shiby Paul; Nadi Atalla; Paul E Thomas; Xinjie Lin; Ill Yang; Brian Buckley; Gang Lu; Xi Zheng; You-Rong Lou; Allan H Conney; Hubert Maehr; Luciano Adorini; Milan Uskokovic; Nanjoo Suh
Gemini vitamin D analogues inhibit estrogen receptor-positive and estrogen receptor-negative mammary tumorigenesis without hypercalcemic toxicity.
Cancer prevention research (Philadelphia, Pa.) 2008;1(6):476-84.
2008: Luciano Adorini; Giuseppe Penna
Control of autoimmune diseases by the vitamin D endocrine system.
Nature clinical practice. Rheumatology 2008;4(8):404-12.
2008: E Borgogni; E Sarchielli; M Sottili; Veronica Santarlasci; Lorenzo Cosmi; Stefania Gelmini; A Lombardi; G Cantini; Giuliano Perigli; Michaela Luconi; Gabriella Barbara Vannelli; Francesco Annunziato; Luciano Adorini; Mario Serio; Clara Crescioli
Elocalcitol inhibits inflammatory responses in human thyroid cells and T cells.
Endocrinology 2008;149(7):3626-34.
2008: Annamaria Morelli; Roberta Squecco; Paola Failli; Sandra Filippi; Linda Vignozzi; Aravinda K Chavalmane; Benedetta Fibbi; Rosa Mancina; Giorgia Luciani; Mauro Gacci; Enrico Colli; Fabio Francini; Luciano Adorini; Mario Maggi
The vitamin D receptor agonist elocalcitol upregulates L-type calcium channel activity in human and rat bladder.
American journal of physiology. Cell physiology 2008;294(5):C1206-14.
2008: Benedetta Fibbi; Annamaria Morelli; Mirca Marini; Xin-Hua Zhang; Rosa Mancina; Linda Vignozzi; Sandra Filippi; Aravinda Chavalmane; Enrico Silvestrini; Enrico Colli; Luciano Adorini; Gabriella Barbara Vannelli; Mario Maggi
Atorvastatin but not elocalcitol increases sildenafil responsiveness in spontaneously hypertensive rats by regulating the RhoA/ROCK pathway.
Journal of andrology 2008;29(1):70-84.
2007: Giuseppe Penna; Susana Amuchastegui; Gilles Laverny; Luciano Adorini
Vitamin D receptor agonists in the treatment of autoimmune diseases: selective targeting of myeloid but not plasmacytoid dendritic cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22 Suppl 2():V69-73.
2007: Giuseppe Penna; Susana Amuchastegui; Chiara Cossetti; Francesca Aquilano; Roberto Mariani; Nadia Giarratana; Elena De Carli; Benedetta Fibbi; Luciano Adorini
Spontaneous and prostatic steroid binding protein peptide-induced autoimmune prostatitis in the nonobese diabetic mouse.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(3):1559-67.
2007: Luciano Adorini; Susana Amuchastegui; Elisa Corsiero; Gilles Laverny; Thomas Le Meur; Giuseppe Penna
Vitamin D receptor agonists as anti-inflammatory agents.
Expert review of clinical immunology 2007;3(4):477-89.
2007: Edward Garay; Pawel Jankowski; Paulo Lizano; Stanislaw Marczak; Hubert Maehr; Luciano Adorini; Milan R Uskokovic; George P Studzinski
Calcitriol derivatives with two different side-chains at C-20. Part 4: further chain modifications that alter VDR-dependent monocytic differentiation potency in human leukemia cells.
Bioorganic & medicinal chemistry 2007;15(13):4444-55.
2007: Catherine Spina; L Ton; Min Yao; Hubert Maehr; M Michael Wolfe; Milan R Uskokovic; Luciano Adorini; Michael F Holick
Selective vitamin D receptor modulators and their effects on colorectal tumor growth.
The Journal of steroid biochemistry and molecular biology 2007;103(3-5):757-62.
2007: Hubert Maehr; Milan R Uskokovic; Luciano Adorini; Giuseppe Penna; Roberto Mariani; Paola Panina; Nadia Passini; Elisa Bono; Silvia Perego; Mauro Biffi; Michael Holick; Catherine Spina; Nanjoo Suh
Calcitriol derivatives with two different side chains at C-20 III. An epimeric pair of the gemini family with unprecedented antiproliferative effects on tumor cells and renin mRNA expression inhibition.
The Journal of steroid biochemistry and molecular biology 2007;103(3-5):277-81.
2007: Luciano Adorini; Giuseppe Penna; Susana Amuchastegui; Chiara Cossetti; Francesca Aquilano; Roberto Mariani; Benedetta Fibbi; Annamaria Morelli; Milan R Uskokovic; Enrico Colli; Mario Maggi
Inhibition of prostate growth and inflammation by the vitamin D receptor agonist BXL-628 (elocalcitol).
The Journal of steroid biochemistry and molecular biology 2007;103(3-5):689-93.
2007: Annamaria Morelli; Linda Vignozzi; Sandra Filippi; Gabriella Barbara Vannelli; Stefano Ambrosini; Rosa Mancina; Clara Crescioli; Silvia Donati; Benedetta Fibbi; Enrico Colli; Luciano Adorini; Mario Maggi
BXL-628, a vitamin D receptor agonist effective in benign prostatic hyperplasia treatment, prevents RhoA activation and inhibits RhoA/Rho kinase signaling in rat and human bladder.
The Prostate 2007;67(3):234-47.
2007: Giuseppe Penna; Massimiliano Di Marco; Susana Amuchastegui; Selene Degli Innocenti; Marco Carini; Gianluca Giubilei; Benedetta Fibbi; Enrico Colli; Mario Maggi; Luciano Adorini
Seminal plasma cytokines and chemokines in prostate inflammation: interleukin 8 as a predictive biomarker in chronic prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia.
European urology 2007;51(2):524-33; discussion 533.
2007: Nadia Giarratana; Giuseppe Penna; Luciano Adorini
Animal models of spontaneous autoimmune disease: type 1 diabetes in the nonobese diabetic mouse.
Methods in molecular biology (Clifton, N.J.) 2007;380():285-311.
2007: Giuseppe Penna; Susana Amuchastegui; Nadia Giarratana; Kenn C Daniel; MARISA VULCANO; Silvano Sozzani; Luciano Adorini
1,25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(1):145-53.
2006: Giuseppe Penna; Susana Amuchastegui; Chiara Cossetti; Francesca Aquilano; Roberto Mariani; Francesca Sanvito; Claudio Doglioni; Luciano Adorini
Treatment of experimental autoimmune prostatitis in nonobese diabetic mice by the vitamin D receptor agonist elocalcitol.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(12):8504-11.
2006: Moray J Campbell; Luciano Adorini
The vitamin D receptor as a therapeutic target.
Expert opinion on therapeutic targets 2006;10(5):735-48.
2006: Mario Maggi; Clara Crescioli; Annamaria Morelli; Enrico Colli; Luciano Adorini
Pre-clinical evidence and clinical translation of benign prostatic hyperplasia treatment by the vitamin D receptor agonist BXL-628 (Elocalcitol).
Journal of endocrinological investigation 2006;29(7):665-74.
2006: Sara Marchiani; Lorella Bonaccorsi; Pietro Ferruzzi; Clara Crescioli; Monica Muratori; Luciano Adorini; Gianni Forti; Mario Maggi; Elisabetta Baldi
The vitamin D analogue BXL-628 inhibits growth factor-stimulated proliferation and invasion of DU145 prostate cancer cells.
Journal of cancer research and clinical oncology 2006;132(6):408-16.
2006: Luciano Adorini; Kenn C Daniel; Giuseppe Penna
Vitamin D receptor agonists, cancer and the immune system: an intricate relationship.
Current topics in medicinal chemistry 2006;6(12):1297-301.
2006: Milan R Uskokovic; Percy Manchand; Stanislaw Marczak; Hubert Maehr; Pawel Jankowski; Luciano Adorini; G Satyanarayana Reddy
C-20 cyclopropyl vitamin D3 analogs.
Current topics in medicinal chemistry 2006;6(12):1289-96.
2005: Giuseppe Penna; Andrea Roncari; Susana Amuchastegui; Kenn C Daniel; Emilio Berti; Marco COLONna; Luciano Adorini
Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+ regulatory T cells by 1,25-dihydroxyvitamin D3.
Blood 2005;106(10):3490-7.
2005: Manuela Del Cornò; Maria Cristina Gauzzi; Giuseppe Penna; Filippo Belardelli; Luciano Adorini; Sandra Gessani
Human immunodeficiency virus type 1 gp120 and other activation stimuli are highly effective in triggering alpha interferon and CC chemokine production in circulating plasmacytoid but not myeloid dendritic cells.
Journal of virology 2005;79(19):12597-601.
2005: Catherine Spina; Vin Tangpricha; Min Yao; W Zhou; M Michael Wolfe; Hubert Maehr; Milan R Uskokovic; Luciano Adorini; Michael F Holick
Colon cancer and solar ultraviolet B radiation and prevention and treatment of colon cancer in mice with vitamin D and its Gemini analogs.
The Journal of steroid biochemistry and molecular biology 2005;97(1-2):111-20.
2005: Elena Riboldi; Tiziana Musso; Emanuela Moroni; Chiara Urbinati; Sergio Bernasconi; MARCO RUSNATI; Luciano Adorini; Marco Presta; Silvano Sozzani
Cutting edge: proangiogenic properties of alternatively activated dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):2788-92.
2005: Luciano Adorini; Susana Amuchastegui; Kenn C Daniel
Prevention of chronic allograft rejection by Vitamin D receptor agonists.
Immunology letters 2005;100(1):34-41.
2005: Angelica P Olcott; Jide Tian; Valerie Walker; Hoa Dang; Blake Middleton; Luciano Adorini; Lorraine Washburn; Daniel L Kaufman
Antigen-based therapies using ignored determinants of beta cell antigens can more effectively inhibit late-stage autoimmune disease in diabetes-prone mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):1991-9.
2005: Susana Amuchastegui; Kenn C Daniel; Luciano Adorini
Inhibition of acute and chronic allograft rejection in mouse models by BXL-628, a nonhypercalcemic vitamin D receptor agonist.
Transplantation 2005;80(1):81-7.
2005: Giuseppe Penna; Nadia Giarratana; Susana Amuchastegui; Roberto Mariani; Kenn C Daniel; Luciano Adorini
Manipulating dendritic cells to induce regulatory T cells.
Microbes and infection / Institut Pasteur 2005;7(7-8):1033-9.
2005: Maria Cristina Gauzzi; Cristina Purificato; Lucia Conti; Luciano Adorini; Filippo Belardelli; Sandra Gessani
IRF-4 expression in the human myeloid lineage: up-regulation during dendritic cell differentiation and inhibition by 1alpha,25-dihydroxyvitamin D3.
Journal of leukocyte biology 2005;77(6):944-7.
2005: Luciano Adorini
Intervention in autoimmunity: the potential of vitamin D receptor agonists.
Cellular immunology 2005;233(2):115-24.
2005: Clara Crescioli; Annamaria Morelli; Luciano Adorini; Pietro Ferruzzi; Michaela Luconi; Gabriella Barbara Vannelli; Mirca Marini; Stefania Gelmini; Benedetta Fibbi; Silvia Donati; Donata Villari; Gianni Forti; Enrico Colli; Karl-Erik Andersson; Mario Maggi
Human bladder as a novel target for vitamin D receptor ligands.
The Journal of clinical endocrinology and metabolism 2005;90(2):962-72.
2005: Maria Cristina Gauzzi; Cristina Purificato; Karim Donato; Yixin Jin; Ling Wang; Kenn C Daniel; Azzam A Maghazachi; Filippo Belardelli; Luciano Adorini; Sandra Gessani
Suppressive effect of 1alpha,25-dihydroxyvitamin D3 on type I IFN-mediated monocyte differentiation into dendritic cells: impairment of functional activities and chemotaxis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):270-6.
2004: Hubert Maehr; Milan R Uskokovic; Luciano Adorini; G Satyanarayana Reddy
Calcitriol derivatives with two different side chains at C-20. II. Diastereoselective syntheses of the metabolically produced 24(R)-hydroxygemini.
Journal of medicinal chemistry 2004;47(26):6476-84.
2004: Luciano Adorini
Antigen-based immunointervention in human autoimmune diseases.
Trends in biotechnology 2004;22(11):547-9.
2004: Nadia Giarratana; Giuseppe Penna; Susana Amuchastegui; Roberto Mariani; Kenn C Daniel; Luciano Adorini
A vitamin D analog down-regulates proinflammatory chemokine production by pancreatic islets inhibiting T cell recruitment and type 1 diabetes development.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2280-7.
2004: Luciano Adorini
Immunotherapeutic approaches in multiple sclerosis.
Journal of the neurological sciences 2004;223(1):13-24.
2004: Luciano Adorini; Giuseppe Penna; Nadia Giarratana; Andrea Roncari; Susana Amuchastegui; Kenn C Daniel; Milan R Uskokovic
Dendritic cells as key targets for immunomodulation by Vitamin D receptor ligands.
The Journal of steroid biochemistry and molecular biology 2004;89-90(1-5):437-41.
2004: Christopher J Olivera; Craig M Bula; June E Bishop; Luciano Adorini; Percy Manchand; Milan R Uskokovic; Anthony W Norman
Characterization of five 19-nor-analogs of 1alpha,25(OH)2-Vitamin D3 with 20-cyclopropyl-modified side-chains: implications for ligand binding and calcemic properties.
The Journal of steroid biochemistry and molecular biology 2004;89-90(1-5):99-106.
2004: Hubert Maehr; Milan R Uskokovic; G Satyanarayana Reddy; Luciano Adorini
Calcitriol derivatives with two different side chains at C-20. 24-hydroxy derivatives as metabolic products and molecular probes for VDR exploration.
The Journal of steroid biochemistry and molecular biology 2004;89-90(1-5):35-8.
2004: Clara Crescioli; Pietro Ferruzzi; Andrea Caporali; Maurizio Scaltriti; Saverio Bettuzzi; Rosa Mancina; Stefania Gelmini; Mario Serio; Donata Villari; Gabriella Barbara Vannelli; Enrico Colli; Luciano Adorini; Mario Maggi
Inhibition of prostate cell growth by BXL-628, a calcitriol analogue selected for a phase II clinical trial in patients with benign prostate hyperplasia.
European journal of endocrinology / European Federation of Endocrine Societies 2004;150(4):591-603.
2004: Luciano Adorini; Nadia Giarratana; Giuseppe Penna
Pharmacological induction of tolerogenic dendritic cells and regulatory T cells.
Seminars in immunology 2004;16(2):127-34.
2004: Francesco Ria; Alexandra Gallard; Claudia Raja Gabaglia; Jean-Charles Guéry; Eli E Sercarz; Luciano Adorini
Selection of similar naive T cell repertoires but induction of distinct T cell responses by native and modified antigen.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3447-53.
2003: Silvia Gregori; Nadia Giarratana; Simona Smiroldo; Luciano Adorini
Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4040-7.
2003: Clara Crescioli; Pietro Ferruzzi; Andrea Caporali; Rosa Mancina; Alessandra Comerci; Monica Muratori; Maurizio Scaltriti; Gabriella Barbara Vannelli; S Smiroldo; R Mariani; Donata Villari; Saverio Bettuzzi; Mario Serio; Luciano Adorini; Mario Maggi
Inhibition of spontaneous and androgen-induced prostate growth by a nonhypercalcemic calcitriol analog.
Endocrinology 2003;144(7):3046-57.
2003: Sylvie Trembleau; Giuseppe Penna; Silvia Gregori; Nadia Giarratana; Luciano Adorini
IL-12 administration accelerates autoimmune diabetes in both wild-type and IFN-gamma-deficient nonobese diabetic mice, revealing pathogenic and protective effects of IL-12-induced IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(11):5491-501.
2003: Nathan R Martinez; Petra Augstein; Antonis K Moustakas; George K Papadopoulos; Silvia Gregori; Luciano Adorini; David C Jackson; Leonard C Harrison
Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide.
The Journal of clinical investigation 2003;111(9):1365-71.
2003: Luciano Adorini
Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting autoimmune diabetes.
Annals of the New York Academy of Sciences 2003;987():258-61.
2003: MARISA VULCANO; Sofie Struyf; Patrizia Scapini; Marco A Cassatella; Sergio Bernasconi; Raffaella Bonecchi; Angelica Calleri; Giuseppe Penna; Luciano Adorini; Walter Luini; Alberto Mantovani; Jo Van Damme; Silvano Sozzani
Unique regulation of CCL18 production by maturing dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(7):3843-9.
2003: Daniele D'Ambrosio; Francesco Sinigaglia; Luciano Adorini
Special attractions for suppressor T cells.
Trends in immunology 2003;24(3):122-6.
2003: Luciano Adorini; Giuseppe Penna; Nadia Giarratana; Milan R Uskokovic
Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases.
Journal of cellular biochemistry 2003;88(2):227-33.
2002: Clara Crescioli; Donata Villari; Gianni Forti; Pietro Ferruzzi; Luisa Petrone; Gabriella Barbara Vannelli; Luciano Adorini; Roberto Salerno; Mario Serio; Mario Maggi
Des (1-3) IGF-I-stimulated growth of human stromal BPH cells is inhibited by a vitamin D3 analogue.
Molecular and cellular endocrinology 2002;198(1-2):69-75.
2002: Giuseppe Penna; MARISA VULCANO; Andrea Roncari; Fabio Facchetti; Silvano Sozzani; Luciano Adorini
Cutting edge: differential chemokine production by myeloid and plasmacytoid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(12):6673-6.
2002: Gianvito Martino; Luciano Adorini; Peter Rieckmann; Jan Hillert; Boris Kallmann; Giancarlo Comi; Massimo Filippi
Inflammation in multiple sclerosis: the good, the bad, and the complex.
Lancet neurology 2002;1(8):499-509.
2002: Luca Polastri; Francesca Galbiati; Federico Bertuzzi; Paolo Fiorina; Rita Nano; Silvia Gregori; Luca Aldrighetti; Guido Pozza; Antonio Secchi; Luciano Adorini; Alberto M Davalli
Secretory defects induced by immunosuppressive agents on human pancreatic beta-cells.
Acta diabetologica 2002;39(4):229-33.
2002: Giuseppe Penna; MARISA VULCANO; Silvano Sozzani; Luciano Adorini
Differential migration behavior and chemokine production by myeloid and plasmacytoid dendritic cells.
Human immunology 2002;63(12):1164-71.
2002: Luciano Adorini
1,25-Dihydroxyvitamin D3 analogs as potential therapies in transplantation.
Current opinion in investigational drugs (London, England : 2000) 2002;3(10):1458-63.
2002: Francesca Galbiati; Luca Polastri; Silvia Gregori; Massimo Freschi; Mara Casorati; Ugo Cavallaro; Paolo Fiorina; Federico Bertuzzi; Alessandro Zerbi; Guido Pozza; Luciano Adorini; Franco Folli; Gerhard Christofori; Alberto M Davalli
Antitumorigenic and antiinsulinogenic effects of calcitriol on insulinoma cells and solid beta-cell tumors.
Endocrinology 2002;143(10):4018-30.
2002: Sandra Columba-Cabezas; Barbara Serafini; Elena Ambrosini; Massimo Sanchez; Giuseppe Penna; Luciano Adorini; Francesca Aloisi
Induction of macrophage-derived chemokine/CCL22 expression in experimental autoimmune encephalomyelitis and cultured microglia: implications for disease regulation.
Journal of neuroimmunology 2002;130(1-2):10-21.
2002: Fabiola Aguilar Torrentera; Jon D Laman; Marjan Van Meurs; Luciano Adorini; Eric Muraille; Yves Carlier
Endogenous interleukin-12 is critical for controlling the late but not the early stage of Leishmania mexicana infection in C57BL/6 mice.
Infection and immunity 2002;70(9):5075-80.
2002: Luciano Adorini
Immunomodulatory effects of vitamin D receptor ligands in autoimmune diseases.
International immunopharmacology 2002;2(7):1017-28.
2002: S I Ymer; Dexing Huang; Giuseppe Penna; Silvia Gregori; K Branson; Luciano Adorini; Grant Morahan
Polymorphisms in the Il12b gene affect structure and expression of IL-12 in NOD and other autoimmune-prone mouse strains.
Genes and immunity 2002;3(3):151-7.
2002: Silvia Gregori; Nadia Giarratana; Simona Smiroldo; Milan R Uskokovic; Luciano Adorini
A 1alpha,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice.
Diabetes 2002;51(5):1367-74.
2002: Chantal Mathieu; Luciano Adorini
The coming of age of 1,25-dihydroxyvitamin D(3) analogs as immunomodulatory agents.
Trends in molecular medicine 2002;8(4):174-9.
2002: Daniela Mazzeo; Silvano Sacco; Pietro Di Lucia; Giuseppe Penna; Luciano Adorini; Paola Panina-Bordignon; Pietro Ghezzi
Thiol antioxidants inhibit the formation of the interleukin-12 heterodimer: a novel mechanism for the inhibition of IL-12 production.
Cytokine 2002;17(6):285-93.
2002: Luciano Adorini; Silvia Gregori; Leonard C Harrison
Understanding autoimmune diabetes: insights from mouse models.
Trends in molecular medicine 2002;8(1):31-8.
2001: Sylvie Trembleau; Silvia Gregori; Giuseppe Penna; I Gorny; Luciano Adorini
IL-12 administration reveals diabetogenic T cells in genetically resistant I-Ealpha-transgenic nonobese diabetic mice: resistance to autoimmune diabetes is associated with binding of Ealpha-derived peptides to the I-A(g7) molecule.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(7):4104-14.
2001: Gianvito Martino; Roberto Furlan; G Comi; Luciano Adorini
The ependymal route to the CNS: an emerging gene-therapy approach for MS.
Trends in immunology 2001;22(9):483-90.
2001: Silvia Gregori; Mara Casorati; S Amuchastegui; Simona Smiroldo; Alberto M Davalli; Luciano Adorini
Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):1945-53.
2001: Giuseppe Penna; S Sozzani; Luciano Adorini
Cutting edge: selective usage of chemokine receptors by plasmacytoid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):1862-6.
2001: Roberto Furlan; Elena Brambilla; Ruffini Francesca; PL Poliani; Alessandra Bergami; Pierfrancesco Marconi; Diego Franciotta; Giuseppe Penna; Giancarlo Comi; Luciano Adorini; Gianvito Martino
Intrathecal delivery of IFN-gamma protects C57BL/6 mice from chronic-progressive experimental autoimmune encephalomyelitis by increasing apoptosis of central nervous system-infiltrating lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1821-9.
2001: Jide Tian; S Gregori; Luciano Adorini; Daniel L Kaufman
The frequency of high avidity T cells determines the hierarchy of determinant spreading.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7144-50.
2001: PL Poliani; Herbert P M Brok; Roberto Furlan; Ruffini Francesca; Alessandra Bergami; G Desina; Pierfrancesco Marconi; Marco Rovaris; Antonio Uccelli; Joseph C Glorioso; Giuseppe Penna; Luciano Adorini; Giancarlo Comi; B 't Hart; Gianvito Martino
Delivery to the central nervous system of a nonreplicative herpes simplex type 1 vector engineered with the interleukin 4 gene protects rhesus monkeys from hyperacute autoimmune encephalomyelitis.
Human gene therapy 2001;12(8):905-20.
2001: Giuseppe Penna; Luciano Adorini
Inhibition of costimulatory pathways for T-cell activation by 1,25-dihydroxyvitamin D(3).
Transplantation proceedings 2001;33(3):2083-4.
2001: Silvia Gregori; Mara Casorati; S Amuchastegui; Simona Smiroldo; Alberto M Davalli; Luciano Adorini
Transplantation tolerance by 1,25-dihydroxyvitamin D(3)-induced costimulation blockade.
Transplantation proceedings 2001;33(1-2):219-20.
2001: Luciano Adorini; Giuseppe Penna; Mara Casorati; Alberto M Davalli; Silvia Gregori
Induction of transplantation tolerance by 1,25-dihydroxyvitamin D(3).
Transplantation proceedings 2001;33(1-2):58-9.
2001: Roberto Furlan; PL Poliani; Pierfrancesco Marconi; Alessandra Bergami; Ruffini Francesca; Luciano Adorini; Joseph C Glorioso; Giancarlo Comi; Gianvito Martino
Central nervous system gene therapy with interleukin-4 inhibits progression of ongoing relapsing-remitting autoimmune encephalomyelitis in Biozzi AB/H mice.
Gene therapy 2001;8(1):13-9.
2001: Francesca Galbiati; Luciano Adorini
Protocol for diversion of a CD4+ response to the T-helper 2 cell pathway.
Methods in molecular biology (Clifton, N.J.) 2001;156():233-44.
2000: Sylvie Trembleau; Giuseppe Penna; Silvia Gregori; Giovanni Magistrelli; Antonella Isacchi; Luciano Adorini
Early Th1 response in unprimed nonobese diabetic mice to the tyrosine phosphatase-like insulinoma-associated protein 2, an autoantigen in type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):6748-55.
2000: Gianvito Martino; PL Poliani; Roberto Furlan; Pierfrancesco Marconi; Joseph C Glorioso; Luciano Adorini; G Comi
Cytokine therapy in immune-mediated demyelinating diseases of the central nervous system: a novel gene therapy approach.
Journal of neuroimmunology 2000;107(2):184-90.
2000: Francesca Aloisi; Barbara Serafini; Luciano Adorini
Glia-T cell dialogue.
Journal of neuroimmunology 2000;107(2):111-7.
2000: Silvia Gregori; Elisa Bono; F Gallazzi; Juergen Hammer; Leonard C Harrison; Luciano Adorini
The motif for peptide binding to the insulin-dependent diabetes mellitus-associated class II MHC molecule I-Ag7 validated by phage display library.
International immunology 2000;12(4):493-503.
2000: Francesca Aloisi; Francesco Ria; Luciano Adorini
Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes.
Immunology today 2000;21(3):141-7.
2000: Giuseppe Penna; Luciano Adorini
1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2405-11.
2000: Francesca Aloisi; R De Simone; Sandra Columba-Cabezas; Giuseppe Penna; Luciano Adorini
Functional maturation of adult mouse resting microglia into an APC is promoted by granulocyte-macrophage colony-stimulating factor and interaction with Th1 cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):1705-12.
2000: F Mattner; Simona Smiroldo; Francesca Galbiati; M Muller; Pietro Di Lucia; PL Poliani; Gianvito Martino; Paola Panina-Bordignon; Luciano Adorini
Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D(3).
European journal of immunology 2000;30(2):498-508.
2000: Francesca Galbiati; Lars Rogge; Luciano Adorini
IL-12 receptor regulation in IL-12-deficient BALB/c and C57BL/6 mice.
European journal of immunology 2000;30(1):29-37.
1999: Francesca Aloisi; Francesco Ria; Sandra Columba-Cabezas; H Hess; Giuseppe Penna; Luciano Adorini
Relative efficiency of microglia, astrocytes, dendritic cells and B cells in naive CD4+ T cell priming and Th1/Th2 cell restimulation.
European journal of immunology 1999;29(9):2705-14.
1999: Sylvie Trembleau; Giuseppe Penna; Silvia Gregori; Harold D Chapman; D V Serreze; J Magram; Luciano Adorini
Pancreas-infiltrating Th1 cells and diabetes develop in IL-12-deficient nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(5):2960-8.
1999: Roberto Furlan; Gianvito Martino; Francesca Galbiati; PL Poliani; Simona Smiroldo; Alessandra Bergami; G Desina; Giancarlo Comi; R Flavell; M S Su; Luciano Adorini
Caspase-1 regulates the inflammatory process leading to autoimmune demyelination.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(5):2403-9.
1999: Silvia Gregori; Sylvie Trembleau; Giuseppe Penna; F Gallazzi; Juergen Hammer; George K Papadopoulos; Luciano Adorini
A peptide binding motif for I-Eg7, the MHC class II molecule that protects E alpha-transgenic nonobese diabetic mice from autoimmune diabetes.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(11):6630-40.
1999: Francesca Aloisi; Giuseppe Penna; E Polazzi; Luisa Minghetti; Luciano Adorini
CD40-CD154 interaction and IFN-gamma are required for IL-12 but not prostaglandin E2 secretion by microglia during antigen presentation to Th1 cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1384-91.
1999: Francesca Galbiati; Luciano Adorini
Non-MHC-linked genetic polymorphism controls selective development of Th2 but not inhibition of Th1 cells by soluble antigen administration.
Microbes and infection / Institut Pasteur 1999;1(1):73-7.
1998: Roberto Furlan; PL Poliani; Francesca Galbiati; Alessandra Bergami; LM Grimaldi; G Comi; Luciano Adorini; Gianvito Martino
Central nervous system delivery of interleukin 4 by a nonreplicative herpes simplex type 1 viral vector ameliorates autoimmune demyelination.
Human gene therapy 1998;9(17):2605-17.
1998: L Moiola; Francesca Galbiati; Gianvito Martino; S Amadio; E Brambilla; G Comi; A Vincent; L M Grimaldi; Luciano Adorini
IL-12 is involved in the induction of experimental autoimmune myasthenia gravis, an antibody-mediated disease.
European journal of immunology 1998;28(8):2487-97.
1998: Gianvito Martino; Roberto Furlan; Francesca Galbiati; PL Poliani; Alessandra Bergami; LM Grimaldi; Luciano Adorini; G Comi
A gene therapy approach to treat demyelinating diseases using non-replicative herpetic vectors engineered to produce cytokines.
Multiple sclerosis (Houndmills, Basingstoke, England) 1998;4(3):222-7.
1998: Francesco Ria; Giuseppe Penna; Luciano Adorini
Th1 cells induce and Th2 inhibit antigen-dependent IL-12 secretion by dendritic cells.
European journal of immunology 1998;28(6):2003-16.
1998: Francesca Aloisi; Francesco Ria; Giuseppe Penna; Luciano Adorini
Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):4671-80.
1998: Francesca Galbiati; Lars Rogge; Jean-Charles Guéry; Simona Smiroldo; Luciano Adorini
Regulation of the IL-12 receptor beta2 subunit by soluble antigen and IL-12 in vivo.
European journal of immunology 1998;28(1):209-20.
1997: Sylvie Trembleau; Giuseppe Penna; Silvia Gregori; M K Gately; Luciano Adorini
Deviation of pancreas-infiltrating cells to Th2 by interleukin-12 antagonist administration inhibits autoimmune diabetes.
European journal of immunology 1997;27(9):2330-9.
1997: Jean-Charles Guéry; Francesca Galbiati; Simona Smiroldo; Luciano Adorini
Non-MHC-linked Th2 cell development induced by soluble protein administration predicts susceptibility to Leishmania major infection.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(5):2147-53.
1997: Francesca Aloisi; Giuseppe Penna; J Cerase; B Menéndez Iglesias; Luciano Adorini
IL-12 production by central nervous system microglia is inhibited by astrocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1604-12.
1997: Jean-Charles Guéry; Francesco Ria; Francesca Galbiati; Luciano Adorini
Normal B cells fail to secrete interleukin-12.
European journal of immunology 1997;27(7):1632-9.
1997: Luciano Adorini; Sylvie Trembleau
Immune deviation towards Th2 inhibits Th-1-mediated autoimmune diabetes.
Biochemical Society transactions 1997;25(2):625-9.
1997: Luciano Adorini; Jean-Charles Guéry; Francesco Ria; Francesca Galbiati
B cells present antigen to CD4+ T cells, but fail to produce IL-12. Selective APC for Th2 cell development?
Annals of the New York Academy of Sciences 1997;815():401-11.
1997: Leonard C Harrison; Margo Honeyman; Sylvie Trembleau; Silvia Gregori; F Gallazzi; Petra Augstein; Vladimir Brusic; Juergen Hammer; Luciano Adorini
A peptide-binding motif for I-A(g7), the class II major histocompatibility complex (MHC) molecule of NOD and Biozzi AB/H mice.
The Journal of experimental medicine 1997;185(6):1013-21.
1997: Luciano Adorini; Francesca Aloisi; Francesca Galbiati; M K Gately; Silvia Gregori; Giuseppe Penna; Francesco Ria; Simona Smiroldo; Sylvie Trembleau
Targeting IL-12, the key cytokine driving Th1-mediated autoimmune diseases.
Chemical immunology 1997;68():175-97.
1997: Jean-Charles Guéry; Francesco Ria; Francesca Galbiati; Luciano Adorini
Antigen presentation and IL-12 production by dendritic cells in vivo.
Advances in experimental medicine and biology 1997;417():317-21.
1997: Jean-Charles Guéry; Francesco Ria; Francesca Galbiati; Simona Smiroldo; Luciano Adorini
The mode of protein antigen administration determines preferential presentation of peptide-class II complexes by lymph node dendritic or B cells.
International immunology 1997;9(1):9-15.
1996: Luciano Adorini; Silvia Gregori; J Magram; Sylvie Trembleau
The role of IL-12 in the pathogenesis of Th1 cell-mediated autoimmune diseases.
Annals of the New York Academy of Sciences 1996;795():208-15.
1996: S Degermann; E Pria; Luciano Adorini
Soluble protein but not peptide administration diverts the immune response of a clonal CD4+ T cell population to the T helper 2 cell pathway.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(8):3260-9.
1996: Jean-Charles Guéry; Francesco Ria; Luciano Adorini
Dendritic cells but not B cells present antigenic complexes to class II-restricted T cells after administration of protein in adjuvant.
The Journal of experimental medicine 1996;183(3):751-7.
1996: J C Guery; Francesca Galbiati; Simona Smiroldo; Luciano Adorini
Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice.
The Journal of experimental medicine 1996;183(2):485-97.
1996: Luciano Adorini; Jean-Charles Guéry; Sylvie Trembleau
Manipulation of the Th1/Th2 cell balance: an approach to treat human autoimmune diseases?
Autoimmunity 1996;23(1):53-68.
1995: Sylvie Trembleau; Patrizio Giacomini; Jean-Charles Guéry; Andrea Setini; Juergen Hammer; A Sette; E Appella; Luciano Adorini
DR alpha: E beta heterodimers in DRA transgenic mice hinder expression of E alpha: E beta molecules and are more efficient in antigen presentation.
International immunology 1995;7(12):1927-38.
1995: Luciano Adorini; J Magram; S Trembeau
The role of endogenous IL12 in the induction of Th1-cell-mediated autoimmune diseases.
Research in immunology 1995;146(7-8):645-51.
1995: Sylvie Trembleau; T Germann; M K Gately; Luciano Adorini
The role of IL-12 in the induction of organ-specific autoimmune diseases.
Immunology today 1995;16(8):383-6.
1995: Sylvie Trembleau; Giuseppe Penna; E Bosi; A Mortara; M K Gately; Luciano Adorini
Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.
The Journal of experimental medicine 1995;181(2):817-21.
1995: Jean-Charles Guéry; A Sette; E Appella; Luciano Adorini
Constitutive presentation of dominant epitopes from endogenous naturally processed self-beta 2-microglobulin to class II-restricted T cells leads to self-tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(2):545-54.
1995: Luciano Adorini; Jean-Charles Guéry; Sylvie Trembleau
Advances in selective immunosuppression.
Advances in pharmacology (San Diego, Calif.) 1995;33():255-85.
1993: Luciano Adorini; Jean-Charles Guéry; S Fuchs; V Ortiz-Navarrete; Günter J Hämmerling; Frank Momburg
Processing of endogenously synthesized hen egg-white lysozyme retained in the endoplasmic reticulum or in secretory form gives rise to a similar but not identical set of epitopes recognized by class II-restricted T cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(7):3576-86.
1993: Luciano Adorini; Jean-Charles Guéry; G Rodriguez-Tarduchy; Sylvie Trembleau
Selective immunosuppression.
Immunology today 1993;14(6):285-9.
1993: U Hurtenbach; E Lier; Luciano Adorini; ZA Nagy
Prevention of autoimmune diabetes in non-obese diabetic mice by treatment with a class II major histocompatibility complex-blocking peptide.
The Journal of experimental medicine 1993;177(5):1499-504.
1993: Jean-Charles Guéry; M Neagu; G Rodriguez-Tarduchy; Luciano Adorini
Selective immunosuppression by administration of major histocompatibility complex class II-binding peptides. II. Preventive inhibition of primary and secondary in vivo antibody responses.
The Journal of experimental medicine 1993;177(5):1461-8.
1993: Luciano Adorini; Jean-Charles Guéry; G Rodriguez-Tarduchy; Sylvie Trembleau
Selective immunosuppression.
Trends in pharmacological sciences 1993;14(5):178-82.
1993: A Valli; A Sette; L Kappos; Carla Oseroff; John Sidney; GC Miescher; M Hochberger; Ekkehard D Albert; Luciano Adorini
Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients.
The Journal of clinical investigation 1993;91(2):616-28.
1993: Luciano Adorini; Jean-Charles Guéry
Suppression of T-cell activation by administration of MHC class II-binding peptides.
Immunology series 1993;59():331-43.
1993: Jean-Charles Guéry; Luciano Adorini
Selective immunosuppression of class II-restricted T cells by MHC class II-binding peptides.
Critical reviews in immunology 1993;13(3-4):195-206.
1992: Jean-Charles Guéry; A Sette; J Leighton; A Dragomir; Luciano Adorini
Selective immunosuppression by administration of major histocompatibility complex (MHC) class II-binding peptides. I. Evidence for in vivo MHC blockade preventing T cell activation.
The Journal of experimental medicine 1992;175(5):1345-52.
1992: Luciano Adorini; Jean-Charles Guéry; Sylvie Trembleau
Approaches toward peptide-based immunotherapy of autoimmune diseases.
Springer seminars in immunopathology 1992;14(2):187-99.
1991: Luciano Adorini; J Moreno; Frank Momburg; Günter J Hämmerling; Jean-Charles Guéry; A Valli; S Fuchs
Exogenous peptides compete for the presentation of endogenous antigens to major histocompatibility complex class II-restricted T cells.
The Journal of experimental medicine 1991;174(4):945-8.
1991: Luciano Adorini; A Valli; Jean-Charles Guéry
Inhibition of T cell activation by blockade of MHC class II molecules.
Seminars in immunology 1991;3(4):231-6.
1991: J Leighton; A Sette; John Sidney; E Appella; C Ehrhardt; S Fuchs; Luciano Adorini
Comparison of structural requirements for interaction of the same peptide with I-Ek and I-Ed molecules in the activation of MHC class II-restricted T cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(1):198-204.
1990: S Muller; Luciano Adorini; A Juretic; ZA Nagy
Selective in vivo inhibition of T cell activation by class II MHC-binding peptides administered in soluble form.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(12):4006-11.