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Patrick Maurel

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Sabine Gerbal-Chaloin; Irena Iankova; Patrick Maurel; Martine Daujat-Chavanieu
Nuclear receptors in the cross-talk of drug metabolism and inflammation.
Mohsan Saeed; Tetsuro Suzuki; Hiroshi Yokokawa; Tomoko Date; Claire Gondeau; Susu Hmwe; Takanobu Kato; Patrick Maurel; Takaji Wakita
Replication of hepatitis C virus genotype 3a in cultured cells.
Jacek Wójcikowski; Patrick Maurel; Wladyslawa A Daniel
Autoinduction of the metabolism of phenothiazine neuroleptics in a primary culture of human hepatocytes.

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All Publications

2013: Sabine Gerbal-Chaloin; Irena Iankova; Patrick Maurel; Martine Daujat-Chavanieu
Nuclear receptors in the cross-talk of drug metabolism and inflammation.
Drug metabolism reviews 2013;45(1):122-44.
2013: Mohsan Saeed; Tetsuro Suzuki; Hiroshi Yokokawa; Tomoko Date; Claire Gondeau; Susu Hmwe; Takanobu Kato; Patrick Maurel; Takaji Wakita
Replication of hepatitis C virus genotype 3a in cultured cells.
Gastroenterology 2013;144(1):56-58.e7.
2012: Jacek Wójcikowski; Patrick Maurel; Wladyslawa A Daniel
Autoinduction of the metabolism of phenothiazine neuroleptics in a primary culture of human hepatocytes.
Pharmacological reports : PR 2012;64(6):1578-83.
2011: Natalie Funakoshi; Pierre Blanc; Martine Daujat-Chavanieu; Cédric Duret; Patrick Maurel; Jean-Marc Pascussi; Sabine Gerbal-Chaloin
Comparison of hepatic-like cell production from human embryonic stem cells and adult liver progenitor cells: CAR transduction activates a battery of detoxification genes.
Stem cell reviews 2011;7(3):518-31.
2011: Bruna Vinci; Cédric Duret; Sylvie Klieber; Sabine Gerbal-Chaloin; Antonio Sa Cunha; Sylvain Laporte; Bertrand Suc; Patrick Maurel; Arti Ahluwalia; Martine Daujat-Chavanieu
Modular bioreactor for primary human hepatocyte culture: medium flow stimulates expression and activity of detoxification genes.
Biotechnology journal 2011;6(5):554-64.
2010: Aneta Novotna; Aneta Doricakova; Radim Vrzal; Patrick Maurel; Petr Pavek; Zdenek Dvorak
Investigation of Orlistat effects on PXR activation and CYP3A4 expression in primary human hepatocytes and human intestinal LS174T cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2010;41(2):276-80.
2010: Radim Vrzal; Sabine Gerbal-Chaloin; Patrick Maurel; Zdenek Dvorák
Comparative effects of microtubules disruption on glucocorticoid receptor functions in proliferating and quiescent cells.
International journal of toxicology 2010;29(3):326-35.
2010: Cyril Breuker; Amélie Moreau; Laila Lakhal; Viola Tamási; Yannick Parmentier; Urs Meyer; Patrick Maurel; Serge Lumbroso; Marie-José Vilarem; Jean-Marc Pascussi
Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3).
Endocrinology 2010;151(4):1653-61.
2010: Lydiane Pichard-Garcia; Philippe Briolotti; Dominique Larrey; Antonio Sa Cunha; Bertrand Suc; Sylvain Laporte; Patrick Maurel
Use of human hepatocytes to investigate HCV infection.
Methods in molecular biology (Clifton, N.J.) 2010;640():447-62.
2010: Christine Biron-Andréani; Edith Raulet; Lydiane Pichard-Garcia; Patrick Maurel
Use of human hepatocytes to investigate blood coagulation factor.
Methods in molecular biology (Clifton, N.J.) 2010;640():431-45.
2010: Sabine Gerbal-Chaloin; Cédric Duret; Edith Raulet; Francis Navarro; Pierre Blanc; Jeanne Ramos; Patrick Maurel; Martine Daujat-Chavanieu
Isolation and culture of adult human liver progenitor cells: in vitro differentiation to hepatocyte-like cells.
Methods in molecular biology (Clifton, N.J.) 2010;640():247-60.
2009: Claire Gondeau; Lydiane Pichard-Garcia; Patrick Maurel
Cellular models for the screening and development of anti-hepatitis C virus agents.
Pharmacology & therapeutics 2009;124(1):1-22.
2009: Jean Paul Brizard; Jeanne Ramos; Agnés Robert; Daniel Lafitte; Nicole Bigi; Pierre Sarda; Dalila Laoudj-Chenivesse; Francis Navarro; Pierre Blanc; eric assenat; Patrick Maurel; Jean-Marc Pascussi; Marie-José Vilarem
Identification of proteomic changes during human liver development by 2D-DIGE and mass spectrometry.
Journal of hepatology 2009;51(1):114-26.
2009: A Moreau; Christelle Téruel; Michel Beylot; Valérie Albalea; Viola Tamási; Thierry Umbdenstock; Yannick Parmentier; Antonio Sa Cunha; Bertrand Suc; Jean-Michel Fabre; Francis Navarro; Jeanne Ramos; Urs Meyer; Patrick Maurel; Marie-José Vilarem; Jean-Marc Pascussi
A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte.
Hepatology (Baltimore, Md.) 2009;49(6):2068-79.
2008: Pavla Henklova; Radim Vrzal; Barbora Papouskova; Petr Bednar; Petra Jancova; Eva Anzenbacherova; Jitka Ulrichova; Patrick Maurel; Petr Pavek; Zdenek Dvorak
SB203580, a pharmacological inhibitor of p38 MAP kinase transduction pathway activates ERK and JNK MAP kinases in primary cultures of human hepatocytes.
European journal of pharmacology 2008;593(1-3):16-23.
2008: Sonia Molina; Dorothée Missé; Stephane Roche; Stéphanie Badiou; Jean-Paul Cristol; Claude Bonfils; Jean-François Dierick; Francisco Veas; Thierry Levayer; Dominique Bonnefont-Rousselot; Patrick Maurel; Joliette Coste; Chantal Fournier-Wirth
Identification of apolipoprotein C-III as a potential plasmatic biomarker associated with the resolution of hepatitis C virus infection.
Proteomics. Clinical applications 2008;2(5):751-61.
2008: Radim Vrzal; Martine Daujat-Chavanieu; Jean-Marc Pascussi; Jitka Ulrichova; Patrick Maurel; Zdenek Dvorak
Microtubules-interfering agents restrict aryl hydrocarbon receptor-mediated CYP1A2 induction in primary cultures of human hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor.
European journal of pharmacology 2008;581(3):244-54.
2008: Tania Onica; Kathleen Nichols; Meghan Larin; Lorraine Ng; Ann Maslen; Zdenek Dvorak; Jean-Marc Pascussi; Marie-José Vilarem; Patrick Maurel; Gordon M Kirby
Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter.
Molecular pharmacology 2008;73(2):451-60.
2008: Zdenek Dvorak; Radim Vrzal; Pavla Henklova; Petra Jancova; Eva Anzenbacherova; Patrick Maurel; Lucie Svecova; Petr Pavek; Jiri Ehrmann; Roman Havlik; Petr Bednar; Karel Lemr; Jitka Ulrichova
JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes.
Biochemical pharmacology 2008;75(2):580-8.
2008: Amélie Moreau; Marie-José Vilarem; Patrick Maurel; Jean-Marc Pascussi
Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response.
Molecular pharmaceutics 2008;5(1):35-41.
2008: Sonia Molina; Valérie Castet; Lydiane Pichard-Garcia; Czeslaw Wychowski; Eliane F Meurs; Jean-Marc Pascussi; Camille Sureau; Jean-Michel Fabre; Antonio SaCunha; Dominique Larrey; Jean Dubuisson; Joliette Coste; Jane A McKeating; Patrick Maurel; Chantal Fournier-Wirth
Serum-derived hepatitis C virus infection of primary human hepatocytes is tetraspanin CD81 dependent.
Journal of virology 2008;82(1):569-74.
2008: Jean-Marc Pascussi; Sabine Gerbal-Chaloin; Cédric Duret; Martine Daujat-Chavanieu; Marie-José Vilarem; Patrick Maurel
The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences.
Annual review of pharmacology and toxicology 2008;48():1-32.
2007: Raul González; Juan A Collado; Sandra Nell; Javier Briceño; María José Tamayo; Enrique Fraga; Angel Bernardos; Pedro López-Cillero; Jean-Marc Pascussi; Sebastian Rufian Peña; Marie-José Vilarem; Manuel De la Mata; Regina Brigelius-Flohe; Patrick Maurel; Jordi Muntané
Cytoprotective properties of alpha-tocopherol are related to gene regulation in cultured D-galactosamine-treated human hepatocytes.
Free radical biology & medicine 2007;43(10):1439-52.
2007: Amélie Moreau; Patrick Maurel; Marie-José Vilarem; Jean-Marc Pascussi
Constitutive androstane receptor-vitamin D receptor crosstalk: consequence on CYP24 gene expression.
Biochemical and biophysical research communications 2007;360(1):76-82.
2007: Georges Abou-Jaoudé; Sonia Molina; Patrick Maurel; Camille Sureau
Myristoylation signal transfer from the large to the middle or the small HBV envelope protein leads to a loss of HDV particles infectivity.
Virology 2007;365(1):204-9.
2007: Cédric Duret; Sabine Gerbal-Chaloin; Jeanne Ramos; Jean-Michel Fabre; Eric Jacquet; Francis Navarro; Pierre Blanc; Antonio Sa Cunha; Patrick Maurel; Martine Daujat-Chavanieu
Isolation, characterization, and differentiation to hepatocyte-like cells of nonparenchymal epithelial cells from adult human liver.
Stem cells (Dayton, Ohio) 2007;25(7):1779-90.
2007: Jean-Marc Pascussi; Agnes Robert; Amelie Moreau; Jeanne Ramos; Paulette Bioulac-Sage; Francis Navarro; Pierre Blanc; eric assenat; Patrick Maurel; Marie-José Vilarem
Differential regulation of constitutive androstane receptor expression by hepatocyte nuclear factor4alpha isoforms.
Hepatology (Baltimore, Md.) 2007;45(5):1146-53.
2007: Sonia Molina; Valérie Castet; Chantal Fournier-Wirth; Lydiane Pichard-Garcia; Rachel Avner; Dror Harats; Joseph Roitelman; Ronald Barbaras; Pierre Graber; Paola Ghersa; Moshe Smolarsky; Ada Funaro; Fabio Malavasi; Dominique Larrey; Joliette Coste; Jean-Michel Fabre; Antonio Sa Cunha; Patrick Maurel
The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus.
Journal of hepatology 2007;46(3):411-9.
2007: Zdenek Dvorák; Patrick Maurel; Marie-José Vilarem; Jitka Ulrichová; Martin Modrianský
Expression and transcriptional activities of nuclear receptors involved in regulation of drug-metabolizing enzymes are not altered by colchicine: focus on PXR, CAR, and GR in primary human hepatocytes.
Cell biology and toxicology 2007;23(2):63-73.
2006: Adrien Breiman; Damien Vitour; Myriam Vilasco; Catherine Ottone; Sonia Molina; Lydiane Pichard; Chantal Fournier; David Delgrange; Pierre Charneau; Gilles Duverlie; Czeslaw Wychowski; Patrick Maurel; Eliane F Meurs
A hepatitis C virus (HCV) NS3/4A protease-dependent strategy for the identification and purification of HCV-infected cells.
The Journal of general virology 2006;87(Pt 12):3587-98.
2006: Jean-Marc Pascussi; Patrick Maurel; Marie-José Vilarem
Response to Zhou et al. Osteomalacia is a frequent complication resulting from long-term therapy with drugs such as phenytoin, carbamazepine, and phenobarbital.
The Journal of clinical investigation 2006;116(10):2564.
2006: Cedric Duret; Martine Daujat-Chavanieu; Jean-Marc Pascussi; Lydiane Pichard-Garcia; Patrick Balaguer; Jean-Michel Fabre; Marie-José Vilarem; Patrick Maurel; Sabine Gerbal-Chaloin
Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.
Molecular pharmacology 2006;70(1):329-39.
2006: Sabine Gerbal-Chaloin; Lydiane Pichard-Garcia; Jean-Michel Fabre; Antonio Sa Cunha; Lorenz Poellinger; Patrick Maurel; Martine Daujat-Chavanieu
Role of CYP3A4 in the regulation of the aryl hydrocarbon receptor by omeprazole sulphide.
Cellular signalling 2006;18(5):740-50.
2006: Zdenek Dvorák; Radim Vrzal; Jitka Ulrichová; Jean-Marc Pascussi; Patrick Maurel; Martin Modriansky
Involvement of cytoskeleton in AhR-dependent CYP1A1 expression.
Current drug metabolism 2006;7(3):301-13.
2006: eric assenat; Sabine Gerbal-Chaloin; Patrick Maurel; Marie-José Vilarem; Jean-Marc Pascussi
Is nuclear factor kappa-B the missing link between inflammation, cancer and alteration in hepatic drug metabolism in patients with cancer?
European journal of cancer (Oxford, England : 1990) 2006;42(6):785-92.
2006: Jacek Wójcikowski; Patrick Maurel; Wladyslawa A Daniel
Characterization of human cytochrome p450 enzymes involved in the metabolism of the piperidine-type phenothiazine neuroleptic thioridazine.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(3):471-6.
2006: Zdenek Dvorák; Radim Vrzal; Patrick Maurel; Jitka Ulrichová
Differential effects of selected natural compounds with anti-inflammatory activity on the glucocorticoid receptor and NF-kappaB in HeLa cells.
Chemico-biological interactions 2006;159(2):117-28.
2006: Lydiane Pichard; Edith Raulet; Gérard Fabre; Jean-Bernard Ferrini; Jean-Claude Ourlin; Patrick Maurel
Human hepatocyte culture.
Methods in molecular biology (Clifton, N.J.) 2006;320():283-93.
2005: Zdenek Dvorák; Martin Modrianský; Jitka Ulrichová; Patrick Maurel; Marie-José Vilarem; Jean-Marc Pascussi
Disruption of microtubules leads to glucocorticoid receptor degradation in HeLa cell line.
Cellular signalling 2005;17(2):187-96.
2005: Pavel Kosina; Patrick Maurel; Jitka Ulrichová; Zdenek Dvorák
Effect of silybin and its glycosides on the expression of cytochromes P450 1A2 and 3A4 in primary cultures of human hepatocytes.
Journal of biochemical and molecular toxicology 2005;19(3):149-53.
2005: Jean-Marc Pascussi; Agnes Robert; Minh Nguyen; Odile Walrant-Debray; Michèle Garabedian; Pascal Martin; Thierry Pineau; Jean Saric; Fréderic Navarro; Patrick Maurel; Marie-José Vilarem
Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia.
The Journal of clinical investigation 2005;115(1):177-86.
2004: Zdenek Dvorák; Patrick Maurel; Jitka Ulrichová; Martin Modrianský
Microtubule disarray in primary cultures of human hepatocytes inhibits transcriptional activity of the glucocorticoid receptor via activation of c-jun N-terminal kinase.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2004;148(2):135-9.
2004: Zdenek Dvorák; Martin Modrianský; Jitka Ulrichová; Patrick Maurel
Speculations on the role of the microtubule network in glucocorticoid receptor signaling.
Cell biology and toxicology 2004;20(6):333-43.
2004: eric assenat; Sabine Gerbal-Chaloin; Dominique Larrey; Jean Saric; Jean-Michel Fabre; Patrick Maurel; Marie-José Vilarem; Jean-Marc Pascussi
Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance.
Hepatology (Baltimore, Md.) 2004;40(4):951-60.
2004: Jean-Marc Pascussi; Sabine Gerbal-Chaloin; Lionel Drocourt; E Assénat; Dominique Larrey; Lydiane Pichard-Garcia; Marie-José Vilarem; Patrick Maurel
Cross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequences.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(7):633-64.
2004: Christine Biron-Andréani; Corinne Bezat-Bouchahda; Edith Raulet; Lydiane Pichard-Garcia; Jean-Michel Fabre; Jean Saric; Jacques Baulieux; Jean-François Schved; Patrick Maurel
Secretion of functional plasma haemostasis proteins in long-term primary cultures of human hepatocytes.
British journal of haematology 2004;125(5):638-46.
2004: Jacek Wójcikowski; Lydiane Pichard-Garcia; Patrick Maurel; Wladyslawa A Daniel
The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2004;14(3):199-208.
2004: Lydiane Pichard-Garcia; Richard John Weaver; Nina Eckett; Graeme Scarfe; Jean-Michel Fabre; Catherine Lucas; Patrick Maurel
The olivacine derivative s 16020 (9-hydroxy-5,6-dimethyl-N-[2-(dimethylamino)ethyl)-6H-pyrido(4,3-B)-carbazole-1-carboxamide) induces CYP1A and its own metabolism in human hepatocytes in primary culture.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(1):80-8.
2003: Jean-Marc Pascussi; Zdenek Dvorák; Sabine Gerbal-Chaloin; eric assenat; Patrick Maurel; Marie-José Vilarem
Pathophysiological factors affecting CAR gene expression.
Drug metabolism reviews 2003;35(4):255-68.
2003: Jean-Claude Ourlin; Frederic Lasserre; Thierry Pineau; Jean-Michel Fabre; Antonio Sa Cunha; Patrick Maurel; Marie-José Vilarem; Jean-Marc Pascussi
The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.
Molecular endocrinology (Baltimore, Md.) 2003;17(9):1693-703.
2003: Jacek Wójcikowski; Lydiane Pichard-Garcia; Patrick Maurel; Wladyslawa A Daniel
Effects of cytochrome P-450 inducers on the perazine metabolism in a primary culture of human hepatocytes.
Polish journal of pharmacology 2003;55(4):655-8.
2003: Zdenek Dvorak; Martin Modriansky; Lydiane Pichard-Garcia; Patrick Balaguer; Marie-José Vilarem; Jitka Ulrichová; Patrick Maurel; Jean-Marc Pascussi
Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation.
Molecular pharmacology 2003;64(1):160-9.
2003: Camille Sureau; Chantal Fournier-Wirth; Patrick Maurel
Role of N glycosylation of hepatitis B virus envelope proteins in morphogenesis and infectivity of hepatitis delta virus.
Journal of virology 2003;77(9):5519-23.
2003: Jacek Wójcikowski; Lydiane Pichard-Garcia; Patrick Maurel; Wladyslawa A Daniel
Contribution of human cytochrome p-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine.
British journal of pharmacology 2003;138(8):1465-74.
2003: Jean-Marc Pascussi; Sabine Gerbal-Chaloin; Lionel Drocourt; Patrick Maurel; Marie-José Vilarem
The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.
Biochimica et biophysica acta 2003;1619(3):243-53.
2003: Elsa Rodrigues; Marie-José Vilarem; Vera Ribeiro; Patrick Maurel; Maria C Lechner
Two CCAAT/enhancer binding protein sites in the cytochrome P4503A1 locus. Potential role in the glucocorticoid response.
European journal of biochemistry / FEBS 2003;270(3):556-64.
2003: Jean-Marc Pascussi; Maryvonne Busson-Le Coniat; Patrick Maurel; Marie-José Vilarem
Transcriptional analysis of the orphan nuclear receptor constitutive androstane receptor (NR1I3) gene promoter: identification of a distal glucocorticoid response element.
Molecular endocrinology (Baltimore, Md.) 2003;17(1):42-55.
2002: Valérie Castet; Chantal Fournier; Alexandre Soulier; Rozenn Brillet; Joliette Coste; Dominique Larrey; Daniel Dhumeaux; Patrick Maurel; Jean-Michel Pawlotsky
Alpha interferon inhibits hepatitis C virus replication in primary human hepatocytes infected in vitro.
Journal of virology 2002;76(16):8189-99.
2002: Lionel Drocourt; Jean-Claude Ourlin; Jean-Marc Pascussi; Patrick Maurel; Marie-José Vilarem
Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.
The Journal of biological chemistry 2002;277(28):25125-32.
2002: Jacek Wójcikowski; Lydiane Pichard-Garcia; Patrick Maurel; Wladyslawa A Daniel
Perazine as a potent inhibitor of human CYP1A2 but not CYP3A4.
Polish journal of pharmacology 2002;54(4):407-10.
2002: Zdenek Dvorak; Jitka Ulrichova; Lydiane Pichard-Garcia; Martin Modriansky; Patrick Maurel
Comparative effect of colchicine and colchiceine on cytotoxicity and CYP gene expression in primary human hepatocytes.
Toxicology in vitro : an international journal published in association with BIBRA 2002;16(3):219-27.
2002: Sabine Gerbal-Chaloin; Martine Daujat; Jean-Marc Pascussi; Lydiane Pichard-Garcia; Marie-José Vilarem; Patrick Maurel
Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor.
The Journal of biological chemistry 2002;277(1):209-17.
2002: Lydiane Pichard-Garcia; Sabine Gerbal-Chaloin; Jean-Bernard Ferrini; Jean-Michel Fabre; Patrick Maurel
Use of long-term cultures of human hepatocytes to study cytochrome P450 gene expression.
Methods in enzymology 2002;357():311-21.
2002: A Kistler; H Liechti; Lydiane Pichard; E Wolz; G Oesterhelt; A Hayes; Patrick Maurel
Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes.
Archives of toxicology 2002;75(11-12):665-75.
2001: Katerina Cervenková; M Belejova; Jaroslav Veselý; Z Chmela; Miroslav Rypka; Jitka Ulrichová; Martin Modrianský; Patrick Maurel
Cell suspensions, cell cultures, and tissue slices--important metabolic in vitro systems.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2001;145(2):57-60.
2001: Jean-Marc Pascussi; Lionel Drocourt; Sabine Gerbal-Chaloin; Jean-Michel Fabre; Patrick Maurel; Marie-José Vilarem
Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.
European journal of biochemistry / FEBS 2001;268(24):6346-58.
2001: Lionel Drocourt; Jean-Marc Pascussi; eric assenat; Jean-Michel Fabre; Patrick Maurel; Marie-José Vilarem
Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(10):1325-31.
2001: Jean-Bernard Ferrini; E Rodrigues; V Dulic; Lydiane Pichard-Garcia; J M Fabr; P Blanc; Patrick Maurel
Expression and DNA-binding activity of C/EBPalpha and C/EBPbeta in human liver and differentiated primary hepatocytes.
Journal of hepatology 2001;35(2):170-7.
2001: Sabine Gerbal-Chaloin; Jean-Marc Pascussi; Lydiane Pichard-Garcia; Martine Daujat; F Waechter; Jean-Michel Fabre; N Carrère; Patrick Maurel
Induction of CYP2C genes in human hepatocytes in primary culture.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(3):242-51.
2000: Jean-Marc Pascussi; Sabine Gerbal-Chaloin; Jean-Michel Fabre; Patrick Maurel; Marie-José Vilarem
Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation.
Molecular pharmacology 2000;58(6):1441-50.
2000: Jean-Marc Pascussi; Sabine Gerbal-Chaloin; Lydiane Pichard-Garcia; Martine Daujat; Jean-Michel Fabre; Patrick Maurel; Marie-José Vilarem
Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes.
Biochemical and biophysical research communications 2000;274(3):707-13.
2000: Jean-Marc Pascussi; Lionel Drocourt; Jean-Michel Fabre; Patrick Maurel; Marie-José Vilarem
Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators.
Molecular pharmacology 2000;58(2):361-72.
2000: Zdenek Dvorák; Jitka Ulrichová; Martin Modrianský; Patrick Maurel
Effect of colchicine and its derivatives on the expression of selected isoforms of cytochrome P450 in primary cultures of human hepatocytes.
Acta Universitatis Palackianae Olomucensis Facultatis Medicae 2000;143():47-50.
2000: Lydiane Pichard-Garcia; R Hyland; J Baulieu; Jean-Michel Fabre; A Milton; Patrick Maurel
Human hepatocytes in primary culture predict lack of cytochrome P-450 3A4 induction by eletriptan in vivo.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(1):51-7.
1999: Jean-Marc Pascussi; Y Jounaidi; Lionel Drocourt; Jacques Domergue; C Balabaud; Patrick Maurel; Marie-José Vilarem
Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene.
Biochemical and biophysical research communications 1999;260(2):377-81.
1998: C Fournier; Camille Sureau; Joliette Coste; Jacques Ducos; Georges-Philippe Pageaux; Dominique Larrey; Jacques Domergue; Patrick Maurel
In vitro infection of adult normal human hepatocytes in primary culture by hepatitis C virus.
The Journal of general virology 1998;79 ( Pt 10)():2367-74.
1998: Jean-Claude Ourlin; Marie-José Vilarem; Martine Daujat; M C Harricane; Patrick Maurel
Lipid-mediated gene transfer into normal adult human hepatocytes in primary culture.
Methods in molecular biology (Clifton, N.J.) 1998;107():371-80.
1998: Jean-Bernard Ferrini; Jean-Claude Ourlin; Lydiane Pichard; G Fabre; Patrick Maurel
Human hepatocyte culture.
Methods in molecular biology (Clifton, N.J.) 1998;107():341-52.
1998: C Calleja; Jean-Marc Pascussi; J C Mani; Patrick Maurel; Marie-José Vilarem
The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor.
Nature medicine 1998;4(1):92-6.
1997: Jean-Bernard Ferrini; Lydiane Pichard; Jacques Domergue; Patrick Maurel
Long-term primary cultures of adult human hepatocytes.
Chemico-biological interactions 1997;107(1-2):31-45.
1997: N Dzeletovic; Jacqueline McGuire; Martine Daujat; J Tholander; M Ema; Y Fujii-Kuriyama; J Bergman; Patrick Maurel; Lorenz Poellinger
Regulation of dioxin receptor function by omeprazole.
The Journal of biological chemistry 1997;272(19):12705-13.
1997: J Greuet; Lydiane Pichard; Jean-Claude Ourlin; C Bonfils; Jacques Domergue; P Le Treut; Patrick Maurel
Effect of cell density and epidermal growth factor on the inducible expression of CYP3A and CYP1A genes in human hepatocytes in primary culture.
Hepatology (Baltimore, Md.) 1997;25(5):1166-75.
1997: Jean-Claude Ourlin; Marie-José Vilarem; Martine Daujat; M C Harricane; Jacques Domergue; H Joyeux; J Baulieux; Patrick Maurel
Lipid-mediated transfection of normal adult human hepatocytes in primary culture.
Analytical biochemistry 1997;247(1):34-44.
1997: Jean-Claude Ourlin; Y Jounaïdi; Patrick Maurel; Marie-José Vilarem
Role of the liver-enriched transcription factors C/EBP alpha and DBP in the expression of human CYP3A4 and CYP3A7.
Journal of hepatology 1997;26 Suppl 2():54-62.
1996: J Greuet; Lydiane Pichard; C Bonfils; Jacques Domergue; Patrick Maurel
The fetal specific gene CYP3A7 is inducible by rifampicin in adult human hepatocytes in primary culture.
Biochemical and biophysical research communications 1996;225(2):689-94.
1996: Martine Daujat; S Charrasse; I Fabre; P Lesca; Y Jounaïdi; C Larroque; Lorenz Poellinger; Patrick Maurel
Induction of CYP1A1 gene by benzimidazole derivatives during Caco-2 cell differentiation. Evidence for an aryl-hydrocarbon receptor-mediated mechanism.
European journal of biochemistry / FEBS 1996;237(3):642-52.
1996: Y Jounaïdi; V Hyrailles; L Gervot; Patrick Maurel
Detection of CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein?
Biochemical and biophysical research communications 1996;221(2):466-70.
1996: Lydiane Pichard; Jacques Domergue; G Fourtanier; P Koch; H F Schran; Patrick Maurel
Metabolism of the new immunosuppressor cyclosporin G by human liver cytochromes P450.
Biochemical pharmacology 1996;51(5):591-8.
1995: Lydiane Pichard; G Gillet; C Bonfils; Jacques Domergue; J P Thénot; Patrick Maurel
Oxidative metabolism of zolpidem by human liver cytochrome P450S.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(11):1253-62.
1995: J Muntané-Relat; Jean-Claude Ourlin; Jacques Domergue; Patrick Maurel
Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture.
Hepatology (Baltimore, Md.) 1995;22(4 Pt 1):1143-53.
1995: P Blanc; J Liautard; J Greuet; J P Daures; J M Fabre; D Larrey; H Michel; Patrick Maurel
Effect of anti-ulcer drugs on DNA synthesis in adult normal human hepatocytes in culture.
Hepatology (Baltimore, Md.) 1995;22(3):814-9.
1995: P Lesca; B Peryt; Gilberte Larrieu; M Alvinerie; Pierre Galtier; Martine Daujat; Patrick Maurel; L Hoogenboom
Evidence for the ligand-independent activation of the AH receptor.
Biochemical and biophysical research communications 1995;209(2):474-82.
1995: Lydiane Pichard; R Curi-Pedrosa; C Bonfils; E Jacqz-Aigrain; Jacques Domergue; H Joyeux; J Cosme; F P Guengerich; Patrick Maurel
Oxidative metabolism of lansoprazole by human liver cytochromes P450.
Molecular pharmacology 1995;47(2):410-8.
1994: Y Jounaïdi; P S Guzelian; Patrick Maurel; Marie-José Vilarem
Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7.
Biochemical and biophysical research communications 1994;205(3):1741-7.
1994: Antoinette Lemoine; Daniel Azoulay; A Dennison; L Kiffel; Lydiane Pichard; V Furlan; T Bienvenu; G Fredj; Brigitte Debuire; Patrick Maurel
FK 506 renal toxicity and lack of detectable cytochrome P-450 3A in the liver graft of a patient undergoing liver transplantation.
Hepatology (Baltimore, Md.) 1994;20(6):1472-7.
1994: P Lesca; R Witkamp; Patrick Maurel; Pierre Galtier
The pig as a model for studying AH receptor and other PAH-binding proteins in man.
Biochemical and biophysical research communications 1994;200(1):475-81.
1994: G R Park; Lydiane Pichard; M Tinel; C Larroque; A Elston; J Domerque; B Dexionne; Patrick Maurel
What changes drug metabolism in critically ill patients? Two preliminary studies in isolated human hepatocytes.
Anaesthesia 1994;49(3):188-9.
1993: X R Zhou-Pan; Eric Sérée; X J Zhou; M Placidi; Patrick Maurel; Yves Barra; Roger Rahmani
Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions.
Cancer research 1993;53(21):5121-6.
1993: Jean-Michel Fabre; R Pedrosa; A Bonardet; Lydiane Pichard; B Descomps; Jacques Domergue; H Baumel; Patrick Maurel
Metabolism of cyclosporine after orthotopic liver transplantation.
Biochemical pharmacology 1993;46(7):1151-7.
1993: P Lesca; B Peryt; S Soues; Patrick Maurel; J P Cravedi
Detection and characterization of a novel hepatic 8 S binding protein for benzo[a]pyrene distinct from the Ah receptor.
Archives of biochemistry and biophysics 1993;303(1):114-24.
1993: Antoinette Lemoine; J C Gautier; Daniel Azoulay; L Kiffel; C Belloc; F P Guengerich; Patrick Maurel; P Beaune; J P Leroux
Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver.
Molecular pharmacology 1993;43(5):827-32.
1993: X J Zhou; X R Zhou-Pan; T Gauthier; M Placidi; Patrick Maurel; Roger Rahmani
Human liver microsomal cytochrome P450 3A isozymes mediated vindesine biotransformation. Metabolic drug interactions.
Biochemical pharmacology 1993;45(4):853-61.
1992: B Peryt; Patrick Maurel; P Lesca
Characterization of the 4 S polycyclic aromatic hydrocarbon-binding protein in human liver and cells.
Archives of biochemistry and biophysics 1992;298(2):420-30.
1992: Martine Daujat; B Peryt; P Lesca; G Fourtanier; Jacques Domergue; Patrick Maurel
Omeprazole, an inducer of human CYP1A1 and 1A2, is not a ligand for the Ah receptor.
Biochemical and biophysical research communications 1992;188(2):820-5.
1992: Lydiane Pichard; I Fabre; Martine Daujat; Jacques Domergue; H Joyeux; Patrick Maurel
Effect of corticosteroids on the expression of cytochromes P450 and on cyclosporin A oxidase activity in primary cultures of human hepatocytes.
Molecular pharmacology 1992;41(6):1047-55.
1992: P Blanc; H Etienne; Martine Daujat; I Fabre; F Zindy; Jacques Domergue; C Astre; B Saint Aubert; H Michel; Patrick Maurel
Mitotic responsiveness of cultured adult human hepatocytes to epidermal growth factor, transforming growth factor alpha, and human serum.
Gastroenterology 1992;102(4 Pt 1):1340-50.
1992: I Dalet-Beluche; X Boulenc; Gérard Fabre; Patrick Maurel; C Bonfils
Purification of two cytochrome P450 isozymes related to CYP2A and CYP3A gene families from monkey (baboon, Papio papio) liver microsomes. Cross reactivity with human forms.
European journal of biochemistry / FEBS 1992;204(2):641-8.
1992: M Maurice; Lydiane Pichard; Martine Daujat; I Fabre; H Joyeux; Jacques Domergue; Patrick Maurel
Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary culture.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(2):752-8.
1992: Jean-Michel Fabre; R Pedrosa; A Bonardet; Lydiane Pichard; B Descomps; Jacques Domergue; H Baumel; Patrick Maurel
[Cyclosporin A metabolism and induction of cytochrome P-450 in orthoptic hepatic transplantation in rats].
Chirurgie; mémoires de l'Académie de chirurgie 1992;118(10):665-71.
1991: P Blanc; H Etienne; Martine Daujat; I Fabre; Lydiane Pichard; Jacques Domergue; H Joyeux; G Fourtanier; Patrick Maurel
Antiproliferative effect of FK 506 and cyclosporine on adult human hepatocytes in culture.
Transplantation proceedings 1991;23(6):2821-4.
1991: Lydiane Pichard; I Fabre; Jacques Domergue; H Joyeux; Patrick Maurel
Effect of FK 506 on human hepatic cytochromes P-450: interaction with CyA.
Transplantation proceedings 1991;23(6):2791-3.
1991: Martine Daujat; P Clair; C Astier; I Fabre; Thierry Pineau; M Yerle; J Gellin; Patrick Maurel
Induction, regulation and messenger half-life of cytochromes P450 IA1, IA2 and IIIA6 in primary cultures of rabbit hepatocytes. CYP 1A1, 1A2 and 3A6 chromosome location in the rabbit and evidence that post-transcriptional control of gene IA2 does not involve mRNA stabilization.
European journal of biochemistry / FEBS 1991;200(2):501-10.
1991: Thierry Pineau; Martine Daujat; Lydiane Pichard; F Girard; J Angevain; C Bonfils; Patrick Maurel
Developmental expression of rabbit cytochrome P450 CYP1A1, CYP1A2 and CYP3A6 genes. Effect of weaning and rifampicin.
European journal of biochemistry / FEBS 1991;197(1):145-53.
1991: Lydiane Pichard; Jean-Michel Fabre; Jacques Domergue; Gérard Fabre; B Saint-Aubert; G Mourad; Patrick Maurel
Molecular mechanism of cyclosporine A drug interactions: inducers and inhibitors of cytochrome P450 screening in primary cultures of human hepatocytes.
Transplantation proceedings 1991;23(1 Pt 2):978-9.
1991: Martine Daujat; Lydiane Pichard; I Fabre; Thierry Pineau; Gérard Fabre; C Bonfils; Patrick Maurel
Induction protocols for cytochromes P450IIIA in vivo and in primary cultures of animal and human hepatocytes.
Methods in enzymology 1991;206():345-53.
1990: D Diaz; I Fabre; Martine Daujat; B Saint Aubert; P Bories; H Michel; Patrick Maurel
Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450.
Gastroenterology 1990;99(3):737-47.
1990: Lydiane Pichard; G Gillet; I Fabre; I Dalet-Beluche; C Bonfils; J P Thenot; Patrick Maurel
Identification of the rabbit and human cytochromes P-450IIIA as the major enzymes involved in the N-demethylation of diltiazem.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(5):711-9.
1990: Lydiane Pichard; I Fabre; Gérard Fabre; Jacques Domergue; B Saint Aubert; G Mourad; Patrick Maurel
Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(5):595-606.
1990: Thierry Pineau; Pierre Galtier; C Bonfils; Jean Derancourt; Patrick Maurel
Purification of a sheep liver cytochrome P-450 from the P450IIIA gene subfamily. Its contribution to the N-dealkylation of veterinary drugs.
Biochemical pharmacology 1990;39(5):901-9.
1990: C Bonfils; J Combalbert; Thierry Pineau; J Angevin; C Larroque; Jean Derancourt; J P Capony; Patrick Maurel
Ontogenesis of rabbit liver cytochrome P450. Evidence for a cytochrome P450-IIE (3a)-related form prevailing during the post-natal period.
European journal of biochemistry / FEBS 1990;188(1):187-94.
1989: Cécile Ged; J M Rouillon; Lydiane Pichard; J Combalbert; N Bressot; P Bories; H Michel; P Beaune; Patrick Maurel
The increase in urinary excretion of 6 beta-hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction.
British journal of clinical pharmacology 1989;28(4):373-87.
1989: C Larroque; R Lange; Patrick Maurel; R Langlois; J E van Lier
Rat liver microsomal progesterone metabolism: evidence for differential troleandomycin and pregnenolone 16 alpha-carbonitrile inductive effects in the cytochrome P-450 III family.
Journal of steroid biochemistry 1989;33(2):277-86.
1989: J Combalbert; I Fabre; Gérard Fabre; I Dalet; Jean Derancourt; J P Cano; Patrick Maurel
Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(2):197-207.
1988: I J Marie; C Dalet; J M Blanchard; Cécile Astre; A Szawlowski; B Saint Aubert; H Joyeux; Patrick Maurel
Inhibition of cytochrome P-450p (P450IIIA1) gene expression during liver regeneration from two-thirds hepatectomy in the rat.
Biochemical pharmacology 1988;37(18):3515-21.
1988: I Fabre; Gérard Fabre; Patrick Maurel; P Bertault-Peres; J P Cano
Metabolism of cyclosporin A. III. Interaction of the macrolide antibiotic, erythromycin, using rabbit hepatocytes and microsomal fractions.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(2):296-301.
1988: C Dalet; P Clair; Martine Daujat; Philippe FORT; J M Blanchard; Patrick Maurel
Complete sequence of cytochrome P450 3c cDNA and presence of two mRNA species with 3' untranslated regions of different lengths.
DNA (Mary Ann Liebert, Inc.) 1988;7(1):39-46.
1987: Martine Daujat; Lydiane Pichard; C Dalet; C Larroque; C Bonfils; Denis POMPON; D Li; P S Guzelian; Patrick Maurel
Expression of five forms of microsomal cytochrome P-450 in primary cultures of rabbit hepatocytes treated with various classes of inducers.
Biochemical pharmacology 1987;36(21):3597-606.
1987: P Bertault-Peres; C Bonfils; Gérard Fabre; S Just; J P Cano; Patrick Maurel
Metabolism of cyclosporin A. II. Implication of the macrolide antibiotic inducible cytochrome P-450 3c from rabbit liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(3):391-8.
1987: Gérard Fabre; P Bertault-Peres; I Fabre; Patrick Maurel; S Just; J P Cano
Metabolism of cyclosporin A. I. Study in freshly isolated rabbit hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(3):384-90.
1986: C Dalet; J M Blanchard; P Guzelian; J Barwick; H Hartle; Patrick Maurel
Cloning of a cDNA coding for P-450 LM3c from rabbit liver microsomes and regulation of its expression.
Nucleic acids research 1986;14(15):5999-6015.
1986: C Bonfils; C Larroque; Patrick Maurel
Purification and characterization of a new form of cytochrome P-450 (LM2b) from untreated male rabbit liver microsomes.
Biochemical and biophysical research communications 1986;134(3):1101-8.
1985: S A Wrighton; Erin G Schuetz; Paul B Watkins; Patrick Maurel; J Barwick; B S Bailey; H T Hartle; B Young; P Guzelian
Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat.
Molecular pharmacology 1985;28(3):312-21.
1985: C Bonfils; I Dalet-Beluche; Patrick Maurel
Triacetyloleandomycin as inducer of cytochrome P-450 LM3c from rabbit liver microsomes.
Biochemical pharmacology 1985;34(14):2445-50.
1983: C Bonfils; C Dalet; I Dalet-Beluche; Patrick Maurel
Cytochrome P-450 isozyme LM3b from rabbit liver microsomes. Induction by triacetyloleandomycin purification and characterization.
The Journal of biological chemistry 1983;258(9):5358-62.
1983: C Dalet; K K Andersson; I Dalet-Beluche; C Bonfils; Patrick Maurel
Polyamines as modulators of drug oxidation reactions catalyzed by cytochrome P-450 from liver microsomes.
Biochemical pharmacology 1983;32(4):593-601.
1982: C Bonfils; I Dalet-Beluche; Patrick Maurel
Induction by triacetyloleandomycin and partial purification of a LM3 form of cytochrome P-450 from rabbit liver microsomes.
Biochemical and biophysical research communications 1982;104(3):1011-7.
1981: C Bonfils; C Balny; Patrick Maurel
Direct evidence for electron transfer from ferrous cytochrome b5 to the oxyferrous intermediate of liver microsomal cytochrome P-450 LM2.
The Journal of biological chemistry 1981;256(18):9457-65.
1981: K K Andersson; C Dalet; C Bonfils; Patrick Maurel
Effect of polyamine on microsomal cytochrome P-450 stimulation of rate and improved coupling of NADPH oxidation to hydroxylation.
Biochemical and biophysical research communications 1981;98(1):311-6.