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Alain Mauviel

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Chemicals & Drugs

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Melanoma

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Carole Y Perrot; Delphine Javelaud; Alain Mauviel
Overlapping activities of TGF-β and Hedgehog signaling in cancer: therapeutic targets for cancer treatment.
Patricia Juárez; Alain Mauviel; Ryan C McKenna; Khalid S Mohammad; Maria Niewolna; Xiang H Peng; Juan Juan Yin; John M Chirgwin; Holly W Davis; Pierrick G J Fournier; Delphine Javelaud; Theresa A Guise
Halofuginone inhibits the establishment and progression of melanoma bone metastases.
Delphine Javelaud; Marie-Jeanne Pierrat; Alain Mauviel
Crosstalk between TGF-β and hedgehog signaling in cancer.

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All Publications

2013: Carole Y Perrot; Delphine Javelaud; Alain Mauviel
Overlapping activities of TGF-β and Hedgehog signaling in cancer: therapeutic targets for cancer treatment.
Pharmacology & therapeutics 2013;137(2):183-99.
2012: Patricia Juárez; Alain Mauviel; Ryan C McKenna; Khalid S Mohammad; Maria Niewolna; Xiang H Peng; Juan Juan Yin; John M Chirgwin; Holly W Davis; Pierrick G J Fournier; Delphine Javelaud; Theresa A Guise
Halofuginone inhibits the establishment and progression of melanoma bone metastases.
Cancer research 2012;72(23):6247-56.
2012: Delphine Javelaud; Marie-Jeanne Pierrat; Alain Mauviel
Crosstalk between TGF-β and hedgehog signaling in cancer.
FEBS letters 2012;586(14):2016-25.
2012: Marie-Jeanne Pierrat; Véronique Marsaud; Alain Mauviel; Delphine Javelaud
Expression of microphthalmia-associated transcription factor (MITF), which is critical for melanoma progression, is inhibited by both transcription factor GLI2 and transforming growth factor-β.
The Journal of biological chemistry 2012;287(22):17996-8004.
2012: Daniel S Widmer; Marie C Zipser; Delphine Javelaud; Alain Mauviel; Natalie Schlegel; Benedetta C Belloni; Phil F Cheng; Reinhard Dummer; Ossia M Eichhoff; Keith Hoek
Systematic classification of melanoma cells by phenotype-specific gene expression mapping.
Pigment cell & melanoma research 2012;25(3):343-53.
2011: Delphine Javelaud; Marie-Jeanne Pierrat; Simon Saule; Leon Van Kempen; Vasileia-Ismini Alexaki; Robert Ballotti; Corine Bertolotto; Véronique Delmas; Sylviane Dennler; Keith S Hoek; Alain Mauviel
GLI2 and M-MITF transcription factors control exclusive gene expression programs and inversely regulate invasion in human melanoma cells.
Pigment cell & melanoma research 2011;24(5):932-43.
2011: Delphine Javelaud; Vasileia I Alexaki; Sylviane Dennler; Theresa A Guise; Khalid S Mohammad; Alain Mauviel
TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis.
Cancer research 2011;71(17):5606-10.
2011: Delphine Javelaud; Leon van Kempen; Vasileia I Alexaki; Erwan Le Scolan; Kunxin Luo; Alain Mauviel
Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression.
Molecular cancer 2011;10(1):2.
2011: Khalid S Mohammad; Delphine Javelaud; Pierrick G J Fournier; Maria Niewolna; C Ryan McKenna; Xiang H Peng; Vu Duong; Lauren K Dunn; Alain Mauviel; Theresa A Guise
TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases.
Cancer research 2011;71(1):175-84.
2010: Kyle A DiVito; Valerie A Trabosh; You-Shin Chen; Yu Chen; Chris Albanese; Delphine Javelaud; Alain Mauviel; Cynthia M Simbulan-Rosenthal; Dean S Rosenthal
Smad7 restricts melanoma invasion by restoring N-cadherin expression and establishing heterotypic cell-cell interactions in vivo.
Pigment cell & melanoma research 2010;23(6):795-808.
2010: Vasileia-Ismini Alexaki; Delphine Javelaud; Leon C L Van Kempen; Khalid S Mohammad; Sylviane Dennler; Flavie Luciani; Keith S Hoek; Patricia Juàrez; James S Goydos; Pierrick J Fournier; Claire Sibon; Corine Bertolotto; Franck Verrecchia; Simon Saule; Veronique Delmas; Robert Ballotti; Lionel Larue; philippe saiag; Theresa A Guise; Alain Mauviel
GLI2-mediated melanoma invasion and metastasis.
Journal of the National Cancer Institute 2010;102(15):1148-59.
2010: Peggy Sextius; Claire Marionnet; Francois-Xavier Bon; Albane Lamy de La Chapelle; Charlotte Tacheau; Morad Lahfa; Alain Mauviel; Bruno A. Bernard; Jacques Leclaire; Françoise Bernerd; Louis Dubertret
Large scale study of epidermal recovery after stratum corneum removal: dynamics of genomic response.
Experimental dermatology 2010;19(3):259-68.
2010: Meinhard Schiller; Sylviane Dennler; Ulf Anderegg; Agatha Kokot; Jan C Simon; Thomas A Luger; Alain Mauviel; Markus Böhm
Increased cAMP levels modulate transforming growth factor-beta/Smad-induced expression of extracellular matrix components and other key fibroblast effector functions.
The Journal of biological chemistry 2010;285(1):409-21.
2009: Sylviane Dennler; Jocelyne André; Franck Verrecchia; Alain Mauviel
Cloning of the human GLI2 Promoter: transcriptional activation by transforming growth factor-beta via SMAD3/beta-catenin cooperation.
The Journal of biological chemistry 2009;284(46):31523-31.
2009: Meryem C Güller; Jocelyne André; Agnès Legrand; Niclas Setterblad; Alain Mauviel; Franck Verrecchia; Fanny Daniel; Dominique Bernuau
c-Fos accelerates hepatocyte conversion to a fibroblastoid phenotype through ERK-mediated upregulation of paxillin-Serine178 phosphorylation.
Molecular carcinogenesis 2009;48(6):532-44.
2009: Sanaa El Marsafy; Martine Bagot; Armand Bensussan; Alain Mauviel
Dendritic cells in the skin--potential use for melanoma treatment.
Pigment cell & melanoma research 2009;22(1):30-41.
2008: Charlotte Tacheau; Juliette Fontaine; Jennifer Loy; Alain Mauviel; Franck Verrecchia
TGF-beta induces connexin43 gene expression in normal murine mammary gland epithelial cells via activation of p38 and PI3K/AKT signaling pathways.
Journal of cellular physiology 2008;217(3):759-68.
2008: Meryem Güller; Kahina Toualbi-Abed; Agnès Legrand; Laurence Michel; Alain Mauviel; Dominique Bernuau; Fanny Daniel
c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1.
World journal of gastroenterology : WJG 2008;14(41):6339-46.
2008: Vasileia-Ismini Alexaki; Delphine Javelaud; Alain Mauviel
JNK supports survival in melanoma cells by controlling cell cycle arrest and apoptosis.
Pigment cell & melanoma research 2008;21(4):429-38.
2008: Chalotte Tacheau; Julien Laboureau; Alain Mauviel; Franck Verrecchia
TNF-alpha represses connexin43 expression in HaCat keratinocytes via activation of JNK signaling.
Journal of cellular physiology 2008;216(2):438-44.
2008: Esther Potier; Elisabeth Ferreira; Sylviane Dennler; Alain Mauviel; Karim Oudina; Delphine Logeart-Avramoglou; Hervé Petite
Desferrioxamine-driven upregulation of angiogenic factor expression by human bone marrow stromal cells.
Journal of tissue engineering and regenerative medicine 2008;2(5):272-8.
2008: Erwan Le Scolan; Qingwei Zhu; Long Wang; Abhik Bandyopadhyay; Delphine Javelaud; Alain Mauviel; Luzhe Sun; Kunxin Luo
Transforming growth factor-beta suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation.
Cancer research 2008;68(9):3277-85.
2008: Delphine Javelaud; Vasileia-Ismini Alexaki; Alain Mauviel
Transforming growth factor-beta in cutaneous melanoma.
Pigment cell & melanoma research 2008;21(2):123-32.
2008: Kahina Toualbi-Abed; Fanny Daniel; Meryem C Güller; Agnès Legrand; Jose Luis Mauriz; Alain Mauviel; Dominique Bernuau
Jun D cooperates with p65 to activate the proximal kappaB site of the cyclin D1 promoter: role of PI3K/PDK-1.
Carcinogenesis 2008;29(3):536-43.
2007: Charlotte Tacheau; Laurence Michel; Dominique Farge; Alain Mauviel; Franck Verrecchia
Involvement of ERK signaling in halofuginone-driven inhibition of fibroblast ability to contract collagen lattices.
European journal of pharmacology 2007;573(1-3):65-9.
2007: Sylviane Dennler; Jocelyne André; Ismini Alexaki; Allen G Li; Thierry Magnaldo; Peter ten Dijke; Xiao-Jing Wang; Franck Verrecchia; Alain Mauviel
Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo.
Cancer research 2007;67(14):6981-6.
2007: Franck Verrecchia; Alain Mauviel
Transforming growth factor-beta and fibrosis.
World journal of gastroenterology : WJG 2007;13(22):3056-62.
2007: Nina Roos; Nicolas Poulalhon; Dominique Farge; Isabelle Madelaine; Alain Mauviel; Franck Verrecchia
In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophenolate mofetil.
The Journal of pharmacology and experimental therapeutics 2007;321(2):583-9.
2007: Franck Verrecchia; Julien Laboureau; O Verola; N Roos; R Porcher; P Bruneval; M Ertault; Kiet Phong TIEV; Laurence Michel; Alain Mauviel; Dominique Farge
Skin involvement in scleroderma--where histological and clinical scores meet.
Rheumatology (Oxford, England) 2007;46(5):833-41.
2007: Delphine Javelaud; Khalid S Mohammad; Christopher R McKenna; Pierrick Fournier; Flavie Luciani; Maryla Niewolna; Jocelyne André; Véronique Delmas; Lionel Larue; Theresa A Guise; Alain Mauviel
Stable overexpression of Smad7 in human melanoma cells impairs bone metastasis.
Cancer research 2007;67(5):2317-24.
2006: Alejandro J Urtreger; Santiago E Werbajh; Franck Verrecchia; Alain Mauviel; Lydia Puricelli; Alberto R Kornblihtt; Elisa Bal de Kier Joffé
Fibronectin is distinctly downregulated in murine mammary adenocarcinoma cells with high metastatic potential.
Oncology reports 2006;16(6):1403-10.
2006: Nicolas Poulalhon; Dominique Farge; Nina Roos; Charlotte Tacheau; Cindy Neuzillet; Laurence Michel; Alain Mauviel; Franck Verrecchia
Modulation of collagen and MMP-1 gene expression in fibroblasts by the immunosuppressive drug rapamycin. A direct role as an antifibrotic agent?
The Journal of biological chemistry 2006;281(44):33045-52.
2006: Franck Verrecchia; Alain Mauviel; Dominique Farge
Transforming growth factor-beta signaling through the Smad proteins: role in systemic sclerosis.
Autoimmunity reviews 2006;5(8):563-9.
2006: Meinhard Schiller; M Böhm; Sylviane Dennler; J M Ehrchen; Alain Mauviel
Mitogen- and stress-activated protein kinase 1 is critical for interleukin-1-induced, CREB-mediated, c-fos gene expression in keratinocytes.
Oncogene 2006;25(32):4449-57.
2006: Marie-Catherine Vozenin-Brotons; Alain Mauviel
[How to model the events in cutaneous fibrosis?].
Médecine sciences : M/S 2006;22(2):172-7.
2006: Sylviane Dennler; Julien Laboureau; Dominique Farge; Alain Mauviel; Franck Verrecchia
[Involvement of TGFbeta1 in fibrotic diseases: role of its effectors, the Smad proteins].
La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne 2006;27(1):46-9.
2005: Delphine Javelaud; Véronique Delmas; Maria Möller; Peggy Sextius; Jocelyne André; Suzanne Menashi; Lionel Larue; Alain Mauviel
Stable overexpression of Smad7 in human melanoma cells inhibits their tumorigenicity in vitro and in vivo.
Oncogene 2005;24(51):7624-9.
2005: Ariel R Krakowski; Julien Laboureau; Alain Mauviel; Mina J Bissell; Kunxin Luo
Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(35):12437-42.
2005: Delphine Javelaud; Alain Mauviel
Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis.
Oncogene 2005;24(37):5742-50.
2005: Sylviane Dennler; Valérie Pendaries; Charlotte Tacheau; Monica Costas; Alain Mauviel; Franck Verrecchia
The steroid receptor co-activator-1 (SRC-1) potentiates TGF-beta/Smad signaling: role of p300/CBP.
Oncogene 2005;24(11):1936-45.
2005: Eric E Gabison; Thanh Hoang-Xuan; Alain Mauviel; Suzanne Menashi
EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair.
Biochimie 2005;87(3-4):361-8.
2005: Alain Mauviel
Transforming growth factor-beta: a key mediator of fibrosis.
Methods in molecular medicine 2005;117():69-80.
2005: Eric E Gabison; SAMIA MOURAH; Emanuelle Steinfels; Li Yan; Thanh Hoang-Xuan; Mitchel A Watsky; Bart De Wever; Fabien Calvo; Alain Mauviel; Suzanne Menashi
Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction.
The American journal of pathology 2005;166(1):209-19.
2004: Meinhard Schiller; Delphine Javelaud; Alain Mauviel
TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing.
Journal of dermatological science 2004;35(2):83-92.
2004: Franck Verrecchia; Alain Mauviel
TGF-beta and TNF-alpha: antagonistic cytokines controlling type I collagen gene expression.
Cellular signalling 2004;16(8):873-80.
2004: Delphine Javelaud; Alain Mauviel
Mammalian transforming growth factor-betas: Smad signaling and physio-pathological roles.
The international journal of biochemistry & cell biology 2004;36(7):1161-5.
2004: Florence Brellier; Claire Marionnet; Odile Chevallier-Lagente; Rune Toftgard; Alain Mauviel; Alain Sarasin; Thierry Magnaldo
Ultraviolet irradiation represses PATCHED gene transcription in human epidermal keratinocytes through an activator protein-1-dependent process.
Cancer research 2004;64(8):2699-704.
2004: Sandhya Xavier; Ester Piek; Makiko Fujii; Delphine Javelaud; Alain Mauviel; Kathleen C Flanders; Amram Samuni; Angelina Felici; Michael Reiss; Shai Yarkoni; Anastasia L Sowers; James B Mitchell; Anita B Roberts; Angelo Russo
Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone.
The Journal of biological chemistry 2004;279(15):15167-76.
2004: Delphine Javelaud; Alain Mauviel
[Transforming growth factor-betas: smad signaling and roles in physiopathology].
Pathologie-biologie 2004;52(1):50-4.
2003: Meinhard Schiller; Franck Verrecchia; Alain Mauviel
Cyclic adenosine 3',5'-monophosphate-elevating agents inhibit transforming growth factor-beta-induced SMAD3/4-dependent transcription via a protein kinase A-dependent mechanism.
Oncogene 2003;22(55):8881-90.
2003: Claire Marionnet; Françoise Bernerd; Arnaud Dumas; Franck Verrecchia; Karine Mollier; Delphine Compan; Bruno A. Bernard; Morad Lahfa; Jacques Leclaire; Chantal Medaisko; Bruno Mehul; Sophie Seité; Alain Mauviel; Louis Dubertret
Modulation of gene expression induced in human epidermis by environmental stress in vivo.
The Journal of investigative dermatology 2003;121(6):1447-58.
2003: Valérie Pendaries; Franck Verrecchia; Serge Michel; Alain Mauviel
Retinoic acid receptors interfere with the TGF-beta/Smad signaling pathway in a ligand-specific manner.
Oncogene 2003;22(50):8212-20.
2003: Maryvonne Laurent; Cécile Martinerie; Hélène Thibout; M P Hoffman; Franck Verrecchia; Yves Le Bouc; Alain Mauviel; H K Kleinman
NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR-alpha-dependent mechanism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(13):1919-21.
2003: Jeanne Wendling; Aimé Marchand; Alain Mauviel; Franck Verrecchia
5-fluorouracil blocks transforming growth factor-beta-induced alpha 2 type I collagen gene (COL1A2) expression in human fibroblasts via c-Jun NH2-terminal kinase/activator protein-1 activation.
Molecular pharmacology 2003;64(3):707-13.
2003: Eric E Gabison; Philippe Chastang; Suzanne Menashi; SAMIA MOURAH; Serge Doan; Michelle Oster; Alain Mauviel; Thanh Hoang-Xuan
Late corneal perforation after photorefractive keratectomy associated with topical diclofenac: involvement of matrix metalloproteinases.
Ophthalmology 2003;110(8):1626-31.
2003: Delphine Javelaud; Julien Laboureau; Eric E Gabison; Franck Verrecchia; Alain Mauviel
Disruption of basal JNK activity differentially affects key fibroblast functions important for wound healing.
The Journal of biological chemistry 2003;278(27):24624-8.
2003: Eric E Gabison; Thanh Hoang-Xuan; Alain Mauviel; Suzanne Menashi
[Metalloproteinases and angiogenesis].
Pathologie-biologie 2003;51(3):161-6.
2003: Kiyoshi Higashi; Yutaka Inagaki; Noriyuki Suzuki; Shinichi Mitsui; Alain Mauviel; Hideo Kaneko; Iwao Nakatsuka
Y-box-binding protein YB-1 mediates transcriptional repression of human alpha 2(I) collagen gene expression by interferon-gamma.
The Journal of biological chemistry 2003;278(7):5156-62.
2003: Franck Verrecchia; Charlotte Tacheau; Erwin F Wagner; Alain Mauviel
A central role for the JNK pathway in mediating the antagonistic activity of pro-inflammatory cytokines against transforming growth factor-beta-driven SMAD3/4-specific gene expression.
The Journal of biological chemistry 2003;278(3):1585-93.
2002: Bertrand Arnulf; Aude Villemain; Christophe Nicot; Elodie Mordelet; Pierre Charneau; Joelle Kersual; Yael Zermati; Alain Mauviel; Ali Bazarbachi; Olivier Hermine
Human T-cell lymphotropic virus oncoprotein Tax represses TGF-beta 1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis.
Blood 2002;100(12):4129-38.
2002: Franck Verrecchia; Erwin F Wagner; Alain Mauviel
Distinct involvement of the Jun-N-terminal kinase and NF-kappaB pathways in the repression of the human COL1A2 gene by TNF-alpha.
EMBO reports 2002;3(11):1069-74.
2002: Marcia Pessah; Jacqueline Marais; Céline Prunier; Nathalie Ferrand; François Lallemand; Alain Mauviel; Azeddine Atfi
c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activity.
The Journal of biological chemistry 2002;277(32):29094-100.
2002: Olivier Ferrigno; François Lallemand; Franck Verrecchia; Sébastien L'Hoste; Jacques Camonis; Azeddine Atfi; Alain Mauviel
Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling.
Oncogene 2002;21(32):4879-84.
2002: Franck Verrecchia; Alain Mauviel
Control of connective tissue gene expression by TGF beta: role of Smad proteins in fibrosis.
Current rheumatology reports 2002;4(2):143-9.
2002: Franck Verrecchia; Alain Mauviel
Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation.
The Journal of investigative dermatology 2002;118(2):211-5.
2001: Franck Verrecchia; L Vindevoghel; Robert J Lechleider; Jouni Uitto; Anita B Roberts; Alain Mauviel
Smad3/AP-1 interactions control transcriptional responses to TGF-beta in a promoter-specific manner.
Oncogene 2001;20(26):3332-40.
2001: Franck Verrecchia; M L Chu; Alain Mauviel
Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach.
The Journal of biological chemistry 2001;276(20):17058-62.
2001: Franck Verrecchia; J Rossert; Alain Mauviel
Blocking sp1 transcription factor broadly inhibits extracellular matrix gene expression in vitro and in vivo: implications for the treatment of tissue fibrosis.
The Journal of investigative dermatology 2001;116(5):755-63.
2001: Franck Verrecchia; Charlotte Tacheau; Marina Schorpp-Kistner; Peter Angel; Alain Mauviel
Induction of the AP-1 members c-Jun and JunB by TGF-beta/Smad suppresses early Smad-driven gene activation.
Oncogene 2001;20(18):2205-11.
2001: DJ Kouba; H Nakano; T Nishiyama; J Kang; Jouni Uitto; Alain Mauviel
Tumor necrosis factor-alpha induces distinctive NF-kappa B signaling within human dermal fibroblasts.
The Journal of biological chemistry 2001;276(9):6214-24.
2001: M P Gras; Franck Verrecchia; Jouni Uitto; Alain Mauviel
Downregulation of human type VII collagen (COL7A1) promoter activity by dexamethasone. Identification of a glucocorticoid receptor binding region.
Experimental dermatology 2001;10(1):28-34.
2000: Franck Verrecchia; Marcia Pessah; Azeddine Atfi; Alain Mauviel
Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation.
The Journal of biological chemistry 2000;275(39):30226-31.
1999: Patrizia Teofoli; Alessandra Frezzolini; Pietro Puddu; Ornella De Pità; Alain Mauviel; Torello Lotti
The role of proopiomelanocortin-derived peptides in skin fibroblast and mast cell functions.
Annals of the New York Academy of Sciences 1999;885():268-76.
1999: Torello Lotti; Patrizia Teofoli; B Bianchi; Alain Mauviel
POMC and fibroblast biology.
Annals of the New York Academy of Sciences 1999;885():262-7.
1999: Sirpa Kivirikko; Alain Mauviel; T Pihlajaniemi; Jouni Uitto
Cytokine modulation of type XV collagen gene expression in human dermal fibroblast cultures.
Experimental dermatology 1999;8(5):407-12.
1999: DJ Kouba; K Y Chung; T Nishiyama; L Vindevoghel; A Kon; John F Klement; Jouni Uitto; Alain Mauviel
Nuclear factor-kappa B mediates TNF-alpha inhibitory effect on alpha 2(I) collagen (COL1A2) gene transcription in human dermal fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(7):4226-34.
1999: A Kon; L Vindevoghel; DJ Kouba; Y Fujimura; Jouni Uitto; Alain Mauviel
Cooperation between SMAD and NF-kappaB in growth factor regulated type VII collagen gene expression.
Oncogene 1999;18(10):1837-44.
1999: Ulrich Rodeck; T Nishiyama; Alain Mauviel
Independent regulation of growth and SMAD-mediated transcription by transforming growth factor beta in human melanoma cells.
Cancer research 1999;59(3):547-50.
1998: L Vindevoghel; Robert J Lechleider; A Kon; Mark de Caestecker; Jouni Uitto; Anita B Roberts; Alain Mauviel
SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14769-74.
1998: L Vindevoghel; A Kon; Robert J Lechleider; Jouni Uitto; Anita B Roberts; Alain Mauviel
Smad-dependent transcriptional activation of human type VII collagen gene (COL7A1) promoter by transforming growth factor-beta.
The Journal of biological chemistry 1998;273(21):13053-7.
1998: K Higashi; DJ Kouba; Y J Song; Jouni Uitto; Alain Mauviel
A proximal element within the human alpha 2(I) collagen (COL1A2) promoter, distinct from the tumor necrosis factor-alpha response element, mediates transcriptional repression by interferon-gamma.
Matrix biology : journal of the International Society for Matrix Biology 1998;16(8):447-56.
1997: Patrizia Teofoli; K Motoki; Torello Lotti; Jouni Uitto; Alain Mauviel
Propiomelanocortin (POMC) gene expression by normal skin and keloid fibroblasts in culture: modulation by cytokines.
Experimental dermatology 1997;6(3):111-5.
1997: L Vindevoghel; K Y Chung; A Davis; DJ Kouba; Sirpa Kivirikko; Hansjuerg Alder; Jouni Uitto; Alain Mauviel
A GT-rich sequence binding the transcription factor Sp1 is crucial for high expression of the human type VII collagen gene (COL7A1) in fibroblasts and keratinocytes.
The Journal of biological chemistry 1997;272(15):10196-204.
1997: Renato V Iozzo; J Pillarisetti; B Sharma; A D Murdoch; Keith G Danielson; Jouni Uitto; Alain Mauviel
Structural and functional characterization of the human perlecan gene promoter. Transcriptional activation by transforming growth factor-beta via a nuclear factor 1-binding element.
The Journal of biological chemistry 1997;272(8):5219-28.
1996: Alain Mauviel; K Korang; Manoranjan Santra; D Tewari; J Uitto; Renato V Iozzo
Identification of a bimodal regulatory element encompassing a canonical AP-1 binding site in the proximal promoter region of the human decorin gene.
The Journal of biological chemistry 1996;271(40):24824-9.
1996: Alain Mauviel; K Y Chung; A Agarwal; K Tamai; Jouni Uitto
Cell-specific induction of distinct oncogenes of the Jun family is responsible for differential regulation of collagenase gene expression by transforming growth factor-beta in fibroblasts and keratinocytes.
The Journal of biological chemistry 1996;271(18):10917-23.
1996: K Y Chung; A Agarwal; Jouni Uitto; Alain Mauviel
An AP-1 binding sequence is essential for regulation of the human alpha2(I) collagen (COL1A2) promoter activity by transforming growth factor-beta.
The Journal of biological chemistry 1996;271(6):3272-8.
1995: K Korang; A M Christiano; J Uitto; Alain Mauviel
Differential cytokine modulation of the genes LAMA3, LAMB3, and LAMC2, encoding the constitutive polypeptides, alpha 3, beta 3, and gamma 2, of human laminin 5 in epidermal keratinocytes.
FEBS letters 1995;368(3):556-8.
1995: Alain Mauviel; Manoranjan Santra; Y Q Chen; J Uitto; Renato V Iozzo
Transcriptional regulation of decorin gene expression. Induction by quiescence and repression by tumor necrosis factor-alpha.
The Journal of biological chemistry 1995;270(19):11692-700.
1995: K Tamai; H Ishikawa; Alain Mauviel; J Uitto
Interferon-gamma coordinately upregulates matrix metalloprotease (MMP)-1 and MMP-3, but not tissue inhibitor of metalloproteases (TIMP), expression in cultured keratinocytes.
The Journal of investigative dermatology 1995;104(3):384-90.
1995: L Li; S Gotta; Alain Mauviel; J Varga
L-tryptophan induces expression of collagenase gene in human fibroblasts: demonstration of enhanced AP-1 binding and AP-1 binding site-driven promoter activity.
Cellular & molecular biology research 1995;41(5):361-8.
1994: Eric F Bernstein; Y Q Chen; K Tamai; K J Shepley; K S Resnik; H Zhang; R Tuan; Alain Mauviel; J Uitto
Enhanced elastin and fibrillin gene expression in chronically photodamaged skin.
The Journal of investigative dermatology 1994;103(2):182-6.
1994: Alain Mauviel; C Halcin; P Vasiloudes; W C Parks; Markku T Kurkinen; J Uitto
Uncoordinate regulation of collagenase, stromelysin, and tissue inhibitor of metalloproteinases genes by prostaglandin E2: selective enhancement of collagenase gene expression in human dermal fibroblasts in culture.
Journal of cellular biochemistry 1994;54(4):465-72.
1994: J Varga; L Li; Alain Mauviel; J Jeffrey; Sergio A Jimenez
L-Tryptophan in supraphysiologic concentrations stimulates collagenase gene expression in human skin fibroblasts.
Laboratory investigation; a journal of technical methods and pathology 1994;70(2):183-91.
1994: Y Q Chen; Alain Mauviel; J Ryynänen; S Sollberg; J Uitto
Type VII collagen gene expression by human skin fibroblasts and keratinocytes in culture: influence of donor age and cytokine responses.
The Journal of investigative dermatology 1994;102(2):205-9.
1994: Alain Mauviel; J C Lapière; C Halcin; C H Evans; J Uitto
Differential cytokine regulation of type I and type VII collagen gene expression in cultured human dermal fibroblasts.
The Journal of biological chemistry 1994;269(1):25-8.
1993: Alain Mauviel
Cytokine regulation of metalloproteinase gene expression.
Journal of cellular biochemistry 1993;53(4):288-95.
1993: Alain Mauviel; Y Q Chen; Veli-Matti Kähäri; I Ledo; M Wu; L Rudnicka; J Uitto
Human recombinant interleukin-1 beta up-regulates elastin gene expression in dermal fibroblasts. Evidence for transcriptional regulation in vitro and in vivo.
The Journal of biological chemistry 1993;268(9):6520-4.
1992: Alain Mauviel; Sakari Reitamo; Anita Remitz; J C Lapière; M Ceska; M Baggiolini; A Walz; C H Evans; J Uitto
Leukoregulin, a T cell-derived cytokine, induces IL-8 gene expression and secretion in human skin fibroblasts. Demonstration and secretion in human skin fibroblasts. Demonstration of enhanced NF-kappa B binding and NF-kappa B-driven promoter activity.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(9):2969-76.
1992: Alain Mauviel; Veli-Matti Kähäri; Markku T Kurkinen; C H Evans; J Uitto
Leukoregulin, a T-cell derived cytokine, upregulates stromelysin-1 gene expression in human dermal fibroblasts: evidence for the role of AP-1 in transcriptional activation.
Journal of cellular biochemistry 1992;50(1):53-61.
1992: Alain Mauviel; C H Evans; J Uitto
Leukoregulin down-regulates type I collagen mRNA levels and promoter activity in human dermal fibroblasts, and counteracts the up-regulation elicited by transforming growth factor-beta.
The Biochemical journal 1992;284 ( Pt 3)():629-32.
1992: Alain Mauviel; Veli-Matti Kähäri; C H Evans; J Uitto
Transcriptional activation of fibroblast collagenase gene expression by a novel lymphokine, leukoregulin.
The Journal of biological chemistry 1992;267(8):5644-8.
1992: Alain Mauviel; Veli-Matti Kähäri; Y Q Chen; Markku T Kurkinen; C H Evans; J Uitto
Transcriptional activation of fibroblast stromelysin-1 and collagenase gene expression by a novel lymphokine, leukoregulin.
Transactions of the Association of American Physicians 1992;105():100-9.