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Patrick Maxwell

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Thomas M F Connor; Daniel P Gale; Guy H Neild; Dorothea Nitsch; D Deren Oygar; Retha Steenkamp; Patrick H Maxwell
Incidence of end-stage renal disease in the Turkish-Cypriot population of Northern Cyprus: a population based study.
Patrick H Maxwell
Increasing evidence that genetic variation in complement factor H related 5 (CFHR5) causes disease: a commentary on 'Atypical haemolytic uremic syndrome and genetic aberrations in the complement factor-H-related 5 gene'.
Clemens A K Lange; Ulrich F O Luhmann; Patrick H Maxwell; Freya M Mowat; Michael B Powner; Haroon Sayed; Alexander J Smith; Jane C Sowden; Emma L West; Sabu Abrahams; Robin R Ali; Marcus Fruttiger; Anastasios Georgiadis; J W B Bainbridge
Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development.

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2013: Thomas M F Connor; Daniel P Gale; Guy H Neild; Dorothea Nitsch; D Deren Oygar; Retha Steenkamp; Patrick H Maxwell
Incidence of end-stage renal disease in the Turkish-Cypriot population of Northern Cyprus: a population based study.
PloS one 2013;8(1):e54394.
2012: Patrick H Maxwell
Increasing evidence that genetic variation in complement factor H related 5 (CFHR5) causes disease: a commentary on 'Atypical haemolytic uremic syndrome and genetic aberrations in the complement factor-H-related 5 gene'.
Journal of human genetics 2012;57(8):473-4.
2012: Clemens A K Lange; Ulrich F O Luhmann; Patrick H Maxwell; Freya M Mowat; Michael B Powner; Haroon Sayed; Alexander J Smith; Jane C Sowden; Emma L West; Sabu Abrahams; Robin R Ali; Marcus Fruttiger; Anastasios Georgiadis; J W B Bainbridge
Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development.
Development (Cambridge, England) 2012;139(13):2340-50.
2012: Freya M Mowat; Alexander J Smith; Robin R Ali; Yanai Duran; Francisco Gonzalez; Clemens A Lange; Ulrich Luhmann; Patrick H Maxwell; J W B Bainbridge
Endogenous erythropoietin protects neuroretinal function in ischemic retinopathy.
The American journal of pathology 2012;180(4):1726-39.
2011: Gunnar Schley; Johannes Schödel; Deepa Shukla; Michael S Wiesener; Kerstin Amann; Kai-Uwe Eckardt; Frauke Forstreuter; Bernd Klanke; Armin Kurtz; Patrick H Maxwell; Seymour Rosen; Carsten Willam
Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury.
Journal of the American Society of Nephrology : JASN 2011;22(11):2004-15.
2011: Julie Adam; Dilair Baban; Peter Carmeliet; Mona El-Bahrawy; Roman Fischer; Norma Frizzell; Emine Hatipoglu; Benedikt M Kessler; Helen Lockstone; Patrick H Maxwell; Emma Nye; Linda O'Flaherty; Christopher W Pugh; Peter J Ratcliffe; Natasha Sahgal; Tomoyoshi Soga; Gordon W Stamp; Marcus Stevens; Nicola Ternette; Kathryn Wolhuter; Patrick J Pollard
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.
Cancer cell 2011;20(4):524-37.
2011: Salwati Shuib; Wenbin Wei; Hariom Sur; Mark Morris; Dominic McMullan; Eleanor Rattenberry; Esther Meyer; Patrick H Maxwell; Takeshi Kishida; Masahiro Yao; Farida Latif; Eamonn R Maher
Copy number profiling in von Hippel-Lindau disease renal cell carcinoma.
Genes, chromosomes & cancer 2011;50(7):479-88.
2011: Federico Formenti; Philip A Beer; Quentin P P Croft; Keith L Dorrington; Daniel P Gale; Terence R J Lappin; Guy S Lucas; Eamonn R Maher; Patrick H Maxwell; Mary F McMullin; David F O'Connor; Melanie J Percy; Christopher W Pugh; Peter J Ratcliffe; Thomas G Smith; Nick P Talbot; Peter A Robbins
Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(6):2001-11.
2011: Sarah K Harten; Margaret Ashcroft; Miguel A Esteban; Deepa Shukla; Patrick H Maxwell
Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells.
Molecular cancer 2011;10():89.
2010: Fredrik Hedborg; Reiner Fischer-Colbrie; Nurtena Ostlin; Bengt Sandstedt; Maxine G B Tran; Patrick H Maxwell
Differentiation in neuroblastoma: diffusion-limited hypoxia induces neuro-endocrine secretory protein 55 and other markers of a chromaffin phenotype.
PloS one 2010;5(9):.
2009: John C Chambers; Weihua Zhang; Yun Li; Joban Sehmi; Mark N Wass; Delilah Zabaneh; Clive J Hoggart; Henry Bayele; Mark I McCarthy; Leena Peltonen; Nelson B Freimer; Kaila Surjit Srai; Patrick H Maxwell; Michael J E Sternberg; Aimo Ruokonen; Goncalo Abecasis; Marjo-Riitta Jarvelin; James Scott; Paul Elliott; Jaspal S Kooner
Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels.
Nature genetics 2009;41(11):1170-2.
2009: Michael S Wiesener; Patrick H Maxwell; Kai-Uwe Eckardt
Novel insights into the role of the tumor suppressor von Hippel Lindau in cellular differentiation, ciliary biology, and cyst repression.
Journal of molecular medicine (Berlin, Germany) 2009;87(9):871-7.
2009: Daqing Ma; Ta Lim; Jing Xu; Haidy Tang; Yanjie Wan; Hailin Zhao; Mahmuda Hossain; Patrick H Maxwell; Mervyn Maze
Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation.
Journal of the American Society of Nephrology : JASN 2009;20(4):713-20.
2009: Melanie Volke; Daniel P Gale; Ulrike Maegdefrau; Gunnar Schley; Bernd Klanke; Anja Bosserhoff; Patrick H Maxwell; Kai-Uwe Eckardt; Christina Warnecke
Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors.
PloS one 2009;4(11):e7875.
2008: Gautam U Mehta; Sharon B Shively; Heng Duong; Maxine G B Tran; Travis J Moncrief; Jonathan H Smith; Jie Li; Nancy A Edwards; Russell R Lonser; Zhengping Zhuang; Marsha J Merrill; Mark Raffeld; Patrick H Maxwell; Edward H Oldfield; Alexander O Vortmeyer
Progression of epididymal maldevelopment into hamartoma-like neoplasia in VHL disease.
Neoplasia (New York, N.Y.) 2008;10(10):1146-53.
2008: Tammie Bishop; Denis Gallagher; Alberto Pascual; Craig A Lygate; Joseph P de Bono; Lynn G Nicholls; Patricia Ortega-Saenz; Henrik Oster; Bhathiya Wijeyekoon; Andrew I Sutherland; Alexandra Grosfeld; Julian Aragones; Martin Schneider; Katie van Geyte; Dania Teixeira; Antonio Diez-juan; Jose Lopez-Barneo; Keith M Channon; Patrick H Maxwell; Christopher W Pugh; Alun M Davies; Peter Carmeliet; Peter J Ratcliffe
Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.
Molecular and cellular biology 2008;28(10):3386-400.
2008: Prapapan Rajatapiti; Irene W J M van der Horst; Jessica D de Rooij; Maxine G B Tran; Patrick H Maxwell; Dick Tibboel; Robbert Rottier; Ronald R de Krijger
Expression of hypoxia-inducible factors in normal human lung development.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2008;11(3):193-9.
2008: Peter Hill; Deepa Shukla; Maxine G B Tran; Julian Aragones; H Terence Cook; Peter Carmeliet; Patrick H Maxwell
Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury.
Journal of the American Society of Nephrology : JASN 2008;19(1):39-46.
2008: Thomas G Smith; J T Brooks; George M Balanos; Terence R J Lappin; D M Layton; D L Leedham; C Liu; Patrick H Maxwell; M F McMullin; C J McNamara; M J Percy; Christopher W Pugh; Peter J Ratcliffe; Nick P Talbot; Marilyn Treacy; Peter A Robbins
Mutation of the von Hippel-Lindau gene alters human cardiopulmonary physiology.
Advances in experimental medicine and biology 2008;605():51-6.
2007: Michael S Wiesener; Philine Münchenhagen; Markus Gläser; Bettina A Sobottka; Karl X Knaup; Katrin Jozefowski; Jan Steffen Jürgensen; Jan Roigas; Christina Warnecke; Hermann-Josef Gröne; Patrick H Maxwell; Carsten Willam; Kai-Uwe Eckardt
Erythropoietin gene expression in renal carcinoma is considerably more frequent than paraneoplastic polycythemia.
International journal of cancer. Journal international du cancer 2007;121(11):2434-42.
2007: Serafim Kiriakidis; Miguel A Esteban; Patrick H Maxwell
Genetic insights into the hypoxia-inducible factor (HIF) pathway.
Advances in enzyme regulation 2007;47():288-306.
2006: Alexander O Vortmeyer; Maxine G B Tran; Weifen Zeng; Sven Gläsker; C Riley; M Tsokos; Barbara Ikejiri; Marsha J Merrill; Mark Raffeld; Zhengping Zhuang; Russell R Lonser; Patrick H Maxwell; Edward H Oldfield
Evolution of VHL tumourigenesis in nerve root tissue.
The Journal of pathology 2006;210(3):374-82.
2006: Sven Gläsker; Maxine G B Tran; S B Shively; Barbara Ikejiri; Russell R Lonser; Patrick H Maxwell; Zhengping Zhuang; Edward H Oldfield; Alexander O Vortmeyer
Epididymal cystadenomas and epithelial tumourlets: effects of VHL deficiency on the human epididymis.
The Journal of pathology 2006;210(1):32-41.
2006: Miguel A Esteban; Sarah K Harten; Maxine G B Tran; Patrick H Maxwell
Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein.
Journal of the American Society of Nephrology : JASN 2006;17(7):1801-6.
2006: Thomas G Smith; Jerome T Brooks; George M Balanos; Terence R J Lappin; D Mark Layton; Dawn L Leedham; Chun Liu; Patrick H Maxwell; Mary Frances McMullin; Christopher J McNamara; Melanie J Percy; Christopher W Pugh; Peter J Ratcliffe; Nick P Talbot; Marilyn Treacy; Peter A Robbins
Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology.
PLoS medicine 2006;3(7):e290.
2006: Carsten Willam; Patrick H Maxwell; Lynn Nichols; Craig A Lygate; Ya-Min Tian; Wanja M Bernhardt; Michael S Wiesener; Peter J Ratcliffe; Kai-Uwe Eckardt; Christopher W Pugh
HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
Journal of molecular and cellular cardiology 2006;41(1):68-77.
2006: Miguel A Esteban; Maxine G B Tran; Sarah K Harten; Peter Hill; Maria C Castellanos; Ashish Chandra; Raju R Raval; Tim S O'brien; Patrick H Maxwell
Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.
Cancer research 2006;66(7):3567-75.
2006: Melanie J Percy; Quan Zhao; Adrian Flores; Claire Harrison; Terence R J Lappin; Patrick H Maxwell; Mary Frances McMullin; Frank S Lee
A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(3):654-9.
2006: Anne R Kinderlerer; Rivka Steinberg; Michael Johns; Sarah K Harten; Elaine A Lidington; Dorian O Haskard; Patrick H Maxwell; Justin C Mason
Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis.
Arthritis research & therapy 2006;8(4):R130.
2005: Daisy W J van der Schaft; Femke Hillen; Patrick Pauwels; Dawn A Kirschmann; Karolien Castermans; mirjam oude egbrink; Maxine G B Tran; Rafael Sciot; Esther Hauben; Pancras Hogendoorn; Olivier Delattre; Patrick H Maxwell; Mary J C Hendrix; Arjan W Griffioen
Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia.
Cancer research 2005;65(24):11520-8.
2005: Sven Gläsker; Russell R Lonser; Maxine G B Tran; Barbara Ikejiri; John A Butman; Weifen Zeng; Patrick H Maxwell; Zhengping Zhuang; Edward H Oldfield; Alexander O Vortmeyer
Effects of VHL deficiency on endolymphatic duct and sac.
Cancer research 2005;65(23):10847-53.
2005: Patrick H Maxwell
Hypoxia-inducible factor as a physiological regulator.
Experimental physiology 2005;90(6):791-7.
2005: Patrick H Maxwell
The HIF pathway in cancer.
Seminars in cell & developmental biology 2005;16(4-5):523-30.
2005: Patrick H Maxwell
A common pathway for genetic events leading to pheochromocytoma.
Cancer cell 2005;8(2):91-3.
2005: Raju R Raval; Kah Weng Lau; Maxine G B Tran; Heidi M Sowter; Stefano J Mandriota; Ji-Liang Li; Christopher W Pugh; Patrick H Maxwell; Adrian L Harris; Peter J Ratcliffe
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.
Molecular and cellular biology 2005;25(13):5675-86.
2004: Jan Steffen Jürgensen; Christian Rosenberger; Michael S Wiesener; Christina Warnecke; Jan H Hörstrup; Michael Gräfe; Sebastian Philipp; Wanja Griethe; Patrick H Maxwell; Ulrich Frei; Sebastian Bachmann; Roland Willenbrock; Kai-Uwe Eckardt
Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(12):1415-7.
2004: Patrick H Maxwell
HIF-1's relationship to oxygen: simple yet sophisticated.
Cell cycle (Georgetown, Tex.) 2004;3(2):156-9.
2004: Carsten Willam; Lynn G Nicholls; Peter J Ratcliffe; Christopher W Pugh; Patrick H Maxwell
The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha.
Advances in enzyme regulation 2004;44():75-92.
2003: Michael S Wiesener; Jan Steffen Jürgensen; Christian Rosenberger; Charlotte K Scholze; Jan H Hörstrup; Christina Warnecke; Stefano J Mandriota; Ingo Bechmann; Ulrich Frei; Christopher W Pugh; Peter J Ratcliffe; Sebastian Bachmann; Patrick H Maxwell; Kai-Uwe Eckardt
Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(2):271-3.
2003: Michael S Wiesener; Patrick H Maxwell
HIF and oxygen sensing; as important to life as the air we breathe?
Annals of medicine 2003;35(3):183-90.
2002: Carsten Willam; Norma Masson; Ya-Min Tian; S Aleema Mahmood; Michael I Wilson; Roy Bicknell; Kai-Uwe Eckardt; Patrick H Maxwell; Peter J Ratcliffe; Christopher W Pugh
Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10423-8.
2002: Patrick H Maxwell
Oxygen homeostasis and cancer: insights from a rare disease.
Clinical medicine (London, England) 2002;2(4):356-62.
2002: Christian Rosenberger; Stefano J Mandriota; Jan Steffen Jürgensen; Michael S Wiesener; Jan H Hörstrup; Ulrich Frei; Peter J Ratcliffe; Patrick H Maxwell; Sebastian Bachmann; Kai-Uwe Eckardt
Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys.
Journal of the American Society of Nephrology : JASN 2002;13(7):1721-32.
2002: Wai-Ching Hon; Michael I Wilson; Karl Harlos; Timothy D W Claridge; Christopher J Schofield; Christopher W Pugh; Patrick H Maxwell; Peter J Ratcliffe; David I Stuart; E Yvonne Jones
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Nature 2002;417(6892):975-8.
2002: Luke A McNeill; Kirsty S Hewitson; Jonathan Gleadle; Louise E Horsfall; Neil J Oldham; Patrick H Maxwell; Christopher W Pugh; Peter J Ratcliffe; Christopher J Schofield
The use of dioxygen by HIF prolyl hydroxylase (PHD1).
Bioorganic & medicinal chemistry letters 2002;12(12):1547-50.
2002: Stefano J Mandriota; Kevin J Turner; David R Davies; Paul G Murray; Neil V Morgan; Heidi M Sowter; Charles C Wykoff; Eamonn R Maher; Adrian L Harris; Peter J Ratcliffe; Patrick H Maxwell
HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron.
Cancer cell 2002;1(5):459-68.
2002: Kevin J Turner; John W Moore; Adam Jones; Claire F Taylor; Darren Cuthbert-Heavens; Cheng Han; Russell Leek; Kevin C Gatter; Patrick H Maxwell; Peter J Ratcliffe; David W Cranston; Adrian L Harris
Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.
Cancer research 2002;62(10):2957-61.
2002: Patrick H Maxwell; Peter J Ratcliffe
Oxygen sensors and angiogenesis.
Seminars in cell & developmental biology 2002;13(1):29-37.
2002: David R Mole; Christopher W Pugh; Peter J Ratcliffe; Patrick H Maxwell
Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.
Advances in enzyme regulation 2002;42():333-47.
2001: EC Vaux; SM Wood; Matthew E Cockman; Lynn G Nicholls; KM Yeates; Christopher W Pugh; Patrick H Maxwell; Peter J Ratcliffe
Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor.
The Journal of biological chemistry 2001;276(47):44323-30.
2001: Andrew C R Epstein; Jonathan Gleadle; Luke A McNeill; Kirsty S Hewitson; JF O'Rourke; David R Mole; Mridul Mukherji; Eric Metzen; Michael I Wilson; A Dhanda; Ya-Min Tian; Norma Masson; D L Hamilton; Panu M Jaakkola; R Barstead; Jonathan Hodgkin; Patrick H Maxwell; Christopher W Pugh; Christopher J Schofield; Peter J Ratcliffe
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
Cell 2001;107(1):43-54.
2001: Norma Masson; Carsten Willam; Patrick H Maxwell; Christopher W Pugh; Peter J Ratcliffe
Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation.
The EMBO journal 2001;20(18):5197-206.
2001: Steven C Clifford; Dewi Astuti; L Hooper; Patrick H Maxwell; Peter J Ratcliffe; Eamonn R Maher
The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma.
Oncogene 2001;20(36):5067-74.
2001: David R Mole; Patrick H Maxwell; Christopher W Pugh; Peter J Ratcliffe
Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.
IUBMB life 2001;52(1-2):43-7.
2001: Michael S Wiesener; Philine Münchenhagen; I Berger; Neil V Morgan; Jan Roigas; A Schwiertz; Jan Steffen Jürgensen; G Gruber; Patrick H Maxwell; S A Löning; Ulrich Frei; Eamonn R Maher; Hermann-Josef Gröne; Kai-Uwe Eckardt
Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas.
Cancer research 2001;61(13):5215-22.
2001: Patrick H Maxwell; Christopher W Pugh; Peter J Ratcliffe
Activation of the HIF pathway in cancer.
Current opinion in genetics & development 2001;11(3):293-9.
2001: Steven C Clifford; Matthew E Cockman; AC Smallwood; David R Mole; Emma R Woodward; Patrick H Maxwell; Peter J Ratcliffe; Eamonn R Maher
Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.
Human molecular genetics 2001;10(10):1029-38.
2001: Patrick H Maxwell; C Buckley; Jonathan Gleadle; P D Mason
Nasty shock after an anti-emetic.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2001;16(5):1069-72.
2001: Panu M Jaakkola; David R Mole; Ya-Min Tian; Michael I Wilson; J Gielbert; S J Gaskell; Holger F Hebestreit; Mridul Mukherji; Christopher J Schofield; Patrick H Maxwell; Christopher W Pugh; A von Kriegsheim; Peter J Ratcliffe
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
Science (New York, N.Y.) 2001;292(5516):468-72.
2001: Patrick H Maxwell; Christopher W Pugh; Peter J Ratcliffe
The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.
Advances in experimental medicine and biology 2001;502():365-76.
2001: Charles C Wykoff; Christopher W Pugh; Adrian L Harris; Patrick H Maxwell; Peter J Ratcliffe
The HIF pathway: implications for patterns of gene expression in cancer.
Novartis Foundation symposium 2001;240():212-25; discussion 225-31.
2001: Christopher W Pugh; Jonathan Gleadle; Patrick H Maxwell
Hypoxia and oxidative stress in breast cancer. Hypoxia signalling pathways.
Breast cancer research : BCR 2001;3(5):313-7.
2000: Charles C Wykoff; Nigel J P Beasley; Peter H Watson; Kevin J Turner; Jaromir Pastorek; Amen Sibtain; George D Wilson; Helen Turley; Kate L Talks; Patrick H Maxwell; Christopher W Pugh; Peter J Ratcliffe; Adrian L Harris
Hypoxia-inducible expression of tumor-associated carbonic anhydrases.
Cancer research 2000;60(24):7075-83.
2000: Charles C Wykoff; Christopher W Pugh; Patrick H Maxwell; Adrian L Harris; Peter J Ratcliffe
Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling.
Oncogene 2000;19(54):6297-305.
2000: Matthew E Cockman; Norma Masson; David R Mole; Panu M Jaakkola; GW Chang; Steven C Clifford; Eamonn R Maher; Christopher W Pugh; Peter J Ratcliffe; Patrick H Maxwell
Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.
The Journal of biological chemistry 2000;275(33):25733-41.
2000: Kate L Talks; Helen Turley; Kevin C Gatter; Patrick H Maxwell; Christopher W Pugh; Peter J Ratcliffe; Adrian L Harris
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
The American journal of pathology 2000;157(2):411-21.
2000: X Ren; Keith L Dorrington; Patrick H Maxwell; Peter A Robbins
Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to hypoxia in humans.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;89(2):680-6.
1999: Patrick H Maxwell; Michael S Wiesener; GW Chang; Steven C Clifford; EC Vaux; Matthew E Cockman; Charles C Wykoff; Christopher W Pugh; Eamonn R Maher; Peter J Ratcliffe
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
Nature 1999;399(6733):271-5.
1999: Christopher W Pugh; GW Chang; Matthew E Cockman; Andrew C R Epstein; Jonathan Gleadle; Patrick H Maxwell; Lynn G Nicholls; JF O'Rourke; Peter J Ratcliffe; E C Raybould; Ya-Min Tian; Michael S Wiesener; M Wood; Charles C Wykoff; KM Yeates
Regulation of gene expression by oxygen levels in mammalian cells.
Advances in nephrology from the Necker Hospital 1999;29():191-206.
1998: Michael S Wiesener; Helen Turley; W E Allen; Carsten Willam; Kai-Uwe Eckardt; Kate L Talks; SM Wood; Kevin C Gatter; Adrian L Harris; Christopher W Pugh; Peter J Ratcliffe; Patrick H Maxwell
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.
Blood 1998;92(7):2260-8.
1998: SM Wood; Michael S Wiesener; KM Yeates; N Okada; Christopher W Pugh; Patrick H Maxwell; Peter J Ratcliffe
Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.
The Journal of biological chemistry 1998;273(14):8360-8.
1998: Peter J Ratcliffe; JF O'Rourke; Patrick H Maxwell; Christopher W Pugh
Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression.
The Journal of experimental biology 1998;201(Pt 8):1153-62.
1997: Peter J Ratcliffe; Patrick H Maxwell; Christopher W Pugh
Beyond erythropoietin: the oxygen sensor.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1997;12(9):1842-8.
1997: Patrick H Maxwell; D J Ferguson; Lynn G Nicholls; M H Johnson; Peter J Ratcliffe
The interstitial response to renal injury: fibroblast-like cells show phenotypic changes and have reduced potential for erythropoietin gene expression.
Kidney international 1997;52(3):715-24.
1997: Patrick H Maxwell; Gabi U Dachs; Jonathan Gleadle; Lynn G Nicholls; Adrian L Harris; Ian Stratford; O Hankinson; Christopher W Pugh; Peter J Ratcliffe
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):8104-9.
1997: Peter J Ratcliffe; B L Ebert; J D Firth; Jonathan Gleadle; Patrick H Maxwell; M Nagao; JF O'Rourke; Christopher W Pugh; SM Wood
Oxygen regulated gene expression: erythropoietin as a model system.
Kidney international 1997;51(2):514-26.
1997: Patrick H Maxwell; D J Ferguson; Lynn G Nicholls; J P Iredale; Christopher W Pugh; M H Johnson; Peter J Ratcliffe
Sites of erythropoietin production.
Kidney international 1997;51(2):393-401.
1997: JF O'Rourke; Gabi U Dachs; Jonathan Gleadle; Patrick H Maxwell; Christopher W Pugh; Ian Stratford; SM Wood; Peter J Ratcliffe
Hypoxia response elements.
Oncology research 1997;9(6-7):327-32.
1995: Peter J Ratcliffe; B L Ebert; D J Ferguson; J D Firth; Jonathan Gleadle; Patrick H Maxwell; Christopher W Pugh
Regulation of the erythropoietin gene.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1995;10 Suppl 2():18-27.
1994: Patrick H Maxwell; D J Ferguson; M K Osmond; Christopher W Pugh; A Heryet; B G Doe; M H Johnson; Peter J Ratcliffe
Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells.
Blood 1994;84(6):1823-30.
1994: Patrick H Maxwell; M K Osmond; Christopher W Pugh; A Heryet; Lynn G Nicholls; C C Tan; B G Doe; D J Ferguson; M H Johnson; Peter J Ratcliffe
Erythropoietin-producing cells in transgenic mice expressing SV40 large T antigen directed by erythropoietin control sequences.
Annals of the New York Academy of Sciences 1994;718():356-8.
1994: Christopher W Pugh; B L Ebert; O Ebrahim; Patrick H Maxwell; Peter J Ratcliffe
Analysis of cis-acting sequences required for operation of the erythropoietin 3' enhancer in different cell lines.
Annals of the New York Academy of Sciences 1994;718():31-9; discussion 39-40.
1993: Patrick H Maxwell; M K Osmond; Christopher W Pugh; A Heryet; Lynn G Nicholls; C C Tan; B G Doe; D J Ferguson; M H Johnson; Peter J Ratcliffe
Identification of the renal erythropoietin-producing cells using transgenic mice.
Kidney international 1993;44(5):1149-62.
1993: Patrick H Maxwell; Christopher W Pugh; Peter J Ratcliffe
Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2423-7.