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Bruce Mayer

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TOP 3
Jonathon A Ditlev; Bruce J Mayer; Leslie M Loew
There is more than one way to model an elephant. Experiment-driven modeling of the actin cytoskeleton.
Dongmyung Oh; Joshua A Jadwin; Kazuya Machida; Bruce J Mayer; Mari Ogiue-Ikeda; Ji Yu
Fast rebinding increases dwell time of Src homology 2 (SH2)-containing proteins near the plasma membrane.
Bruce J Mayer
Perspective: Dynamics of receptor tyrosine kinase signaling complexes.

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All Publications

2013: Jonathon A Ditlev; Bruce J Mayer; Leslie M Loew
There is more than one way to model an elephant. Experiment-driven modeling of the actin cytoskeleton.
Biophysical journal 2013;104(3):520-32.
2012: Dongmyung Oh; Joshua A Jadwin; Kazuya Machida; Bruce J Mayer; Mari Ogiue-Ikeda; Ji Yu
Fast rebinding increases dwell time of Src homology 2 (SH2)-containing proteins near the plasma membrane.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(35):14024-9.
2012: Bruce J Mayer
Perspective: Dynamics of receptor tyrosine kinase signaling complexes.
FEBS letters 2012;586(17):2575-9.
2012: Jonathon A Ditlev; Greg Huber; Leslie M Loew; Paul J Michalski; William A Mohler; Gonzalo M Rivera; Bruce J Mayer
Stoichiometry of Nck-dependent actin polymerization in living cells.
The Journal of cell biology 2012;197(5):643-58.
2010: J Zheng; K Machida; S Antoku; K Y Ng; Kevin P Claffey; Bruce J Mayer
Proteins that bind the Src homology 3 domain of CrkI have distinct roles in Crk transformation.
Oncogene 2010;29(48):6378-89.
2010: Kazuya Machida; Steven Eschrich; Jiannong Li; Yun Bai; John Koomen; Bruce J Mayer; Eric Haura
Characterizing tyrosine phosphorylation signaling in lung cancer using SH2 profiling.
PloS one 2010;5(10):e13470.
2009: Susumu Antoku; Bruce J Mayer
Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signals.
Journal of cell science 2009;122(Pt 22):4228-38.
2009: Bruce J Mayer; Michael L Blinov; Leslie M Loew
Molecular machines or pleiomorphic ensembles: signaling complexes revisited.
Journal of biology 2009;8(9):81.
2009: Kazuya Machida; Bruce J Mayer
Detection of protein-protein interactions by far-western blotting.
Methods in molecular biology (Clifton, N.J.) 2009;536():313-29.
2008: Susumu Antoku; Kalle Saksela; Gonzalo M Rivera; Bruce J Mayer
A crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors.
Journal of cell science 2008;121(Pt 18):3071-82.
2008: Bruce J Mayer
Clues to the evolution of complex signaling machinery.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(28):9453-4.
2007: Kazuya Machida; Christopher M Thompson; Kevin Dierck; Karl Jablonowski; Satu Kärkkäinen; Bernard Liu; Haimin Zhang; Bernard Liu; Debra K Newman; Peter Nollau; Tony Pawson; G Herma Renkema; Kalle Saksela; Martin R Schiller; Dong-guk Shin; Bruce J Mayer
High-throughput phosphotyrosine profiling using SH2 domains.
Molecular cell 2007;26(6):899-915.
2006: Kevin Dierck; Kazuya Machida; Anja Voigt; Julian Thimm; Martin Horstmann; Walter Fiedler; Bruce J Mayer; Peter Nollau
Quantitative multiplexed profiling of cellular signaling networks using phosphotyrosine-specific DNA-tagged SH2 domains.
Nature methods 2006;3(9):737-44.
2006: G M Rivera; S Antoku; S Gelkop; Nah-Young Shin; Steven K Hanks; T Pawson; Bruce J Mayer
Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(25):9536-41.
2006: Bruce J Mayer
Protein-protein interactions in signaling cascades.
Methods in molecular biology (Clifton, N.J.) 2006;332():79-99.
2005: Kazuya Machida; Bruce J Mayer
The SH2 domain: versatile signaling module and pharmaceutical target.
Biochimica et biophysica acta 2005;1747(1):1-25.
2004: Gonzalo M Rivera; César A Briceño; Fuminao Takeshima; Scott B Snapper; Bruce J Mayer
Inducible clustering of membrane-targeted SH3 domains of the adaptor protein Nck triggers localized actin polymerization.
Current biology : CB 2004;14(1):11-22.
2003: Alok Sharma; Susumu Antoku; Kosaku Fujiwara; Bruce J Mayer
Functional interaction trap: a strategy for validating the functional consequences of tyrosine phosphorylation of specific substrates in vivo.
Molecular & cellular proteomics : MCP 2003;2(11):1217-24.
2003: Kazuya Machida; Bruce J Mayer; Peter Nollau
Profiling the global tyrosine phosphorylation state.
Molecular & cellular proteomics : MCP 2003;2(4):215-33.
2002: Kosaku Fujiwara; Kari Poikonen; Lourdes Aleman; Minna Valtavaara; Kalle Saksela; Bruce J Mayer
A single-chain antibody/epitope system for functional analysis of protein-protein interactions.
Biochemistry 2002;41(42):12729-38.
2002: Maria Carla Parrini; Ming Lei; Stephen C Harrison; Bruce J Mayer
Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1.
Molecular cell 2002;9(1):73-83.
2001: Peter Nollau; Bruce J Mayer
Profiling the global tyrosine phosphorylation state by Src homology 2 domain binding.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13531-6.
2001: Rajat Rohatgi; Peter Nollau; Hsin-Yi Henry Ho; Marc W Kirschner; Bruce J Mayer
Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway.
The Journal of biological chemistry 2001;276(28):26448-52.
2001: Tohru Miyoshi-Akiyama; Lourdes Aleman; J M Smith; carolyn adler; Bruce J Mayer
Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor.
Oncogene 2001;20(30):4058-69.
2001: Bruce J Mayer
SH3 domains: complexity in moderation.
Journal of cell science 2001;114(Pt 7):1253-63.
2000: carolyn adler; Tohru Miyoshi-Akiyama; Lourdes Aleman; M Tanaka; J M Smith; Bruce J Mayer
Abl family kinases and Cbl cooperate with the Nck adaptor to modulate Xenopus development.
The Journal of biological chemistry 2000;275(46):36472-8.
2000: Ming Lei; W Lu; W Meng; Maria Carla Parrini; Michael J Eck; Bruce J Mayer; Stephen C Harrison
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.
Cell 2000;102(3):387-97.
2000: F Chen; Le Ma; Maria Carla Parrini; X Mao; M Lopez; C Wu; Peter W Marks; L Davidson; David J Kwiatkowski; Tomas Kirchhausen; Stuart H Orkin; F S Rosen; Bruce J Mayer; Marc W Kirschner; F W Alt
Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability.
Current biology : CB 2000;10(13):758-65.
1999: Bruce J Mayer
Protein-protein interactions in signaling cascades.
Molecular biotechnology 1999;13(3):201-13.
1999: Mark W Kieran; S Katz; B Vail; Leonard I Zon; Bruce J Mayer
Concentration-dependent positive and negative regulation of a MAP kinase by a MAP kinase kinase.
Oncogene 1999;18(48):6647-57.
1999: Maria Carla Parrini; Bruce J Mayer
Engineering temperature-sensitive SH3 domains.
Chemistry & biology 1999;6(10):679-87.
1999: J M Smith; S Katz; Bruce J Mayer
Activation of the Abl tyrosine kinase in vivo by Src homology 3 domains from the Src homology 2/Src homology 3 adaptor Nck.
The Journal of biological chemistry 1999;274(39):27956-62.
1999: Bruce J Mayer
Endocytosis: EH domains lend a hand.
Current biology : CB 1999;9(2):R70-3.
1999: W Lu; Bruce J Mayer
Mechanism of activation of Pak1 kinase by membrane localization.
Oncogene 1999;18(3):797-806.
1998: R W Gupta; Bruce J Mayer
Dominant-negative mutants of the SH2/SH3 adapters Nck and Grb2 inhibit MAP kinase activation and mesoderm-specific gene induction by eFGF in Xenopus.
Oncogene 1998;17(17):2155-65.
1998: Aki Manninen; Marita Hiipakka; Mauno Vihinen; W Lu; Bruce J Mayer; Kalle Saksela
SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase.
Virology 1998;250(2):273-82.
1998: Bruce J Mayer
Protein-protein interactions in signaling cascades.
Methods in molecular biology (Clifton, N.J.) 1998;84():33-48.
1998: Bruce J Mayer; R Gupta
Functions of SH2 and SH3 domains.
Current topics in microbiology and immunology 1998;228():1-22.
1997: Bruce J Mayer
Signal transduction: clamping down on Src activity.
Current biology : CB 1997;7(5):R295-8.
1997: M Tanaka; W Lu; R Gupta; Bruce J Mayer
Expression of mutated Nck SH2/SH3 adaptor respecifies mesodermal cell fate in Xenopus laevis development.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4493-8.
1997: W Lu; S Katz; R Gupta; Bruce J Mayer
Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.
Current biology : CB 1997;7(2):85-94.
1995: M Tanaka; R Gupta; Bruce J Mayer
Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins.
Molecular and cellular biology 1995;15(12):6829-37.
1995: Bruce J Mayer; Michael J Eck
SH3 domains. Minding your p's and q's.
Current biology : CB 1995;5(4):364-7.
1995: Bruce J Mayer; H Hirai; R Sakai
Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases.
Current biology : CB 1995;5(3):296-305.