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Mark Mayer

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TOP 3
Suvendu Lomash; Patrick Brown; Sagar Chittori; Mark L Mayer
Anions mediate ligand binding in Adineta vaga glutamate receptor ion channels.
Janesh Kumar; Mark L Mayer
Functional insights from glutamate receptor ion channel structures.
Mark L Mayer
Emerging models of glutamate receptor ion channel structure and function.

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All Publications

2013: Suvendu Lomash; Patrick Brown; Sagar Chittori; Mark L Mayer
Anions mediate ligand binding in Adineta vaga glutamate receptor ion channels.
Structure (London, England : 1993) 2013;21(3):414-25.
2013: Janesh Kumar; Mark L Mayer
Functional insights from glutamate receptor ion channel structures.
Annual review of physiology 2013;75():313-37.
2011: Mark L Mayer
Emerging models of glutamate receptor ion channel structure and function.
Structure (London, England : 1993) 2011;19(10):1370-80.
2011: Janesh Kumar; Peter Schuck; Mark L Mayer
Structure and assembly mechanism for heteromeric kainate receptors.
Neuron 2011;71(2):319-31.
2011: Mark L Mayer
Structure and mechanism of glutamate receptor ion channel assembly, activation and modulation.
Current opinion in neurobiology 2011;21(2):283-90.
2011: Mark L Mayer
Glutamate receptor ion channels: where do all the calories go?
Nature structural & molecular biology 2011;18(3):253-4.
2011: Gregory M Alushin; David E Jane; Mark L Mayer
Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists.
Neuropharmacology 2011;60(1):126-34.
2010: Utpal Das; Janesh Kumar; Mark L Mayer; Andrew J R Plested
Domain organization and function in GluK2 subtype kainate receptors.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(18):8463-8.
2009: Andrew J R Plested; Mark L Mayer
AMPA receptor ligand binding domain mobility revealed by functional cross linking.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(38):11912-23.
2009: Charu Chaudhry; Andrew J R Plested; Peter Schuck; Mark L Mayer
Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(30):12329-34.
2009: Janesh Kumar; Peter Schuck; Rongsheng Jin; Mark L Mayer
The N-terminal domain of GluR6-subtype glutamate receptor ion channels.
Nature structural & molecular biology 2009;16(6):631-8.
2009: Charu Chaudhry; Matthew C Weston; Peter Schuck; Christian Rosenmund; Mark L Mayer
Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization.
The EMBO journal 2009;28(10):1518-30.
2009: Sheila L Dargan; Vernon R J Clarke; Gregory M Alushin; John L Sherwood; Robert Nisticò; Zuner A Bortolotto; Ann M Ogden; David Bleakman; Andrew J Doherty; David Lodge; Mark L Mayer; Stephen Fitzjohn; David E Jane; Graham Collingridge
ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function.
Neuropharmacology 2009;56(1):121-30.
2009: Andrew J R Plested; Mark L Mayer
Engineering a high-affinity allosteric binding site for divalent cations in kainate receptors.
Neuropharmacology 2009;56(1):114-20.
2008: Yongneng Yao; Chris B Harrison; Peter L Freddolino; Klaus Schulten; Mark L Mayer
Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors.
The EMBO journal 2008;27(15):2158-70.
2008: Andrew J R Plested; Ranjit Vijayan; Philip C Biggin; Mark L Mayer
Molecular basis of kainate receptor modulation by sodium.
Neuron 2008;58(5):720-35.
2007: Nigel P Dolman; Julia C A More; Andrew Alt; Jody L Knauss; Olli Pentikäinen; Carla R Glasser; David Bleakman; Mark L Mayer; Graham Collingridge; David E Jane
Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists.
Journal of medicinal chemistry 2007;50(7):1558-70.
2007: Andrew J R Plested; Mark L Mayer
Structure and mechanism of kainate receptor modulation by anions.
Neuron 2007;53(6):829-41.
2006: Matthew C Weston; Peter Schuck; Alokesh Ghosal; christian rosenmund; Mark L Mayer
Conformational restriction blocks glutamate receptor desensitization.
Nature structural & molecular biology 2006;13(12):1120-7.
2006: Matthew C Weston; Christoph Gertler; Mark L Mayer; christian rosenmund
Interdomain interactions in AMPA and kainate receptors regulate affinity for glutamate.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(29):7650-8.
2006: Yongneng Yao; Mark L Mayer
Characterization of a soluble ligand binding domain of the NMDA receptor regulatory subunit NR3A.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(17):4559-66.
2006: Mark L Mayer; Alokesh Ghosal; Nigel P Dolman; David E Jane
Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(11):2852-61.
2005: Mark L Mayer
Glutamate receptor ion channels.
Current opinion in neurobiology 2005;15(3):282-8.
2005: Mark L Mayer
Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity.
Neuron 2005;45(4):539-52.
2004: Michelle S Horning; Mark L Mayer
Regulation of AMPA receptor gating by ligand binding core dimers.
Neuron 2004;41(3):379-88.
2004: Mark L Mayer; Neali Armstrong
Structure and function of glutamate receptor ion channels.
Annual review of physiology 2004;66():161-81.
2003: Rongsheng Jin; Tue G Banke; Mark L Mayer; Stephen F Traynelis; James Eric Gouaux
Structural basis for partial agonist action at ionotropic glutamate receptors.
Nature neuroscience 2003;6(8):803-10.
2002: Rongsheng Jin; Michelle Horning; Mark L Mayer; James Eric Gouaux
Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate.
Biochemistry 2002;41(52):15635-43.
2002: Anders Hogner; Jette S Kastrup; R Jin; Tommy Liljefors; Mark L Mayer; Jan Egebjerg; Ingrid K Larsen; James Eric Gouaux
Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core.
Journal of molecular biology 2002;322(1):93-109.
2001: Mark L Mayer; Rich Olson; James Eric Gouaux
Mechanisms for ligand binding to GluR0 ion channels: crystal structures of the glutamate and serine complexes and a closed apo state.
Journal of molecular biology 2001;311(4):815-36.
2001: V A Panchenko; Carla R Glasser; Mark L Mayer
Structural similarities between glutamate receptor channels and K(+) channels examined by scanning mutagenesis.
The Journal of general physiology 2001;117(4):345-60.
1999: G Q Chen; Changhai Cui; Mark L Mayer; James Eric Gouaux
Functional characterization of a potassium-selective prokaryotic glutamate receptor.
Nature 1999;402(6763):817-21.
1999: V A Panchenko; Carla R Glasser; K M Partin; Mark L Mayer
Amino acid substitutions in the pore of rat glutamate receptors at sites influencing block by polyamines.
The Journal of physiology 1999;520 Pt 2():337-57.
1999: Changhai Cui; Mark L Mayer
Heteromeric kainate receptors formed by the coassembly of GluR5, GluR6, and GluR7.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(19):8281-91.
1998: Derek Bowie; G David Lange; Mark L Mayer
Activity-dependent modulation of glutamate receptors by polyamines.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(20):8175-85.
1998: C Cu; R Bähring; Mark L Mayer; C Cui
The role of hydrophobic interactions in binding of polyamines to non NMDA receptor ion channels.
Neuropharmacology 1998;37(10-11):1381-91.
1998: R Bähring; Mark L Mayer
An analysis of philanthotoxin block for recombinant rat GluR6(Q) glutamate receptor channels.
The Journal of physiology 1998;509 ( Pt 3)():635-50.
1997: R Bähring; Derek Bowie; Morris J Benveniste; Mark L Mayer
Permeation and block of rat GluR6 glutamate receptor channels by internal and external polyamines.
The Journal of physiology 1997;502 ( Pt 3)():575-89.
1997: Masayuki Sekiguchi; MW Fleck; Mark L Mayer; J Takeo; Y Chiba; S Yamashita; Keiji Wada
A novel allosteric potentiator of AMPA receptors: 4--2-(phenylsulfonylamino)ethylthio--2,6-difluoro-phenoxyaceta mide.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(15):5760-71.
1997: Li-Jin Chew; MW Fleck; P Wright; SE Scherer; Mark L Mayer; Vittorio Gallo
Growth factor-induced transcription of GluR1 increases functional AMPA receptor density in glial progenitor cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(1):227-40.
1996: K M Partin; MW Fleck; Mark L Mayer
AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(21):6634-47.
1996: MW Fleck; R Bähring; D K Patneau; Mark L Mayer
AMPA receptor heterogeneity in rat hippocampal neurons revealed by differential sensitivity to cyclothiazide.
Journal of neurophysiology 1996;75(6):2322-33.
1996: K M Partin; Mark L Mayer
Negative allosteric modulation of wild-type and mutant AMPA receptors by GYKI 53655.
Molecular pharmacology 1996;49(1):142-8.
1995: Derek Bowie; Mark L Mayer
Inward rectification of both AMPA and kainate subtype glutamate receptors generated by polyamine-mediated ion channel block.
Neuron 1995;15(2):453-62.
1995: K M Partin; Derek Bowie; Mark L Mayer
Structural determinants of allosteric regulation in alternatively spliced AMPA receptors.
Neuron 1995;14(4):833-43.
1995: Morris J Benveniste; Mark L Mayer
Trapping of glutamate and glycine during open channel block of rat hippocampal neuron NMDA receptors by 9-aminoacridine.
The Journal of physiology 1995;483 ( Pt 2)():367-84.
1994: K M Partin; D K Patneau; Mark L Mayer
Cyclothiazide differentially modulates desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants.
Molecular pharmacology 1994;46(1):129-38.
1994: Chris J McBain; Mark L Mayer
N-methyl-D-aspartic acid receptor structure and function.
Physiological reviews 1994;74(3):723-60.
1994: Vittorio Gallo; D K Patneau; Mark L Mayer; Flora M Vaccarino
Excitatory amino acid receptors in glial progenitor cells: molecular and functional properties.
Glia 1994;11(2):94-101.
1994: L A Wong; Mark L Mayer; D E Jane; J C Watkins
Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(6):3881-97.
1994: D K Patneau; P W Wright; C Winters; Mark L Mayer; Vittorio Gallo
Glial cells of the oligodendrocyte lineage express both kainate- and AMPA-preferring subtypes of glutamate receptor.
Neuron 1994;12(2):357-71.
1993: K M Partin; D K Patneau; C A Winters; Mark L Mayer; Andres Buonanno
Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A.
Neuron 1993;11(6):1069-82.
1993: L A Wong; Mark L Mayer
Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors.
Molecular pharmacology 1993;44(3):504-10.
1993: D K Patneau; L Vyklicky; Mark L Mayer
Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(8):3496-509.
1993: Morris J Benveniste; Mark L Mayer
Multiple effects of spermine on N-methyl-D-aspartic acid receptor responses of rat cultured hippocampal neurones.
The Journal of physiology 1993;464():131-63.
1992: Morris J Benveniste; Mark L Mayer
Effect of extracellular pH on the potency of N-methyl-D-aspartic acid receptor competitive antagonists.
Molecular pharmacology 1992;42(4):679-86.
1992: Mark L Mayer; Morris J Benveniste; D K Patneau; L Vyklicky
Pharmacologic properties of NMDA receptors.
Annals of the New York Academy of Sciences 1992;648():194-204.
1992: D K Patneau; Mark L Mayer; D E Jane; J C Watkins
Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(2):595-606.
1991: L Vyklicky; D K Patneau; Mark L Mayer
Modulation of excitatory synaptic transmission by drugs that reduce desensitization at AMPA/kainate receptors.
Neuron 1991;7(6):971-84.
1991: Morris J Benveniste; Mark L Mayer
Structure-activity analysis of binding kinetics for NMDA receptor competitive antagonists: the influence of conformational restriction.
British journal of pharmacology 1991;104(1):207-21.
1991: D K Patneau; Mark L Mayer
Kinetic analysis of interactions between kainate and AMPA: evidence for activation of a single receptor in mouse hippocampal neurons.
Neuron 1991;6(5):785-98.
1991: Morris J Benveniste; Mark L Mayer
Kinetic analysis of antagonist action at N-methyl-D-aspartic acid receptors. Two binding sites each for glutamate and glycine.
Biophysical journal 1991;59(3):560-73.
1990: Mark L Mayer
Glutamate: three meetings but how many receptors? Excitatory Amino Acids 1990: a Fidia Research Foundation Symposium, Padua, Italy, May 21-26, 1990. Excitatory Amino Acid Receptors in the Brain: Functions and Disorders, Montreal, Canada, June 23-24, 1990. Excitatory Amino Acids: an Update Official Satellite of the XIth IUPHAR Congress, Flims, Switzerland, June 28-29, 1990.
The New biologist 1990;2(10):865-9.
1990: L Vyklický; Morris J Benveniste; Mark L Mayer
Modulation of N-methyl-D-aspartic acid receptor desensitization by glycine in mouse cultured hippocampal neurones.
The Journal of physiology 1990;428():313-31.
1990: Morris J Benveniste; J Clements; L Vyklický; Mark L Mayer
A kinetic analysis of the modulation of N-methyl-D-aspartic acid receptors by glycine in mouse cultured hippocampal neurones.
The Journal of physiology 1990;428():333-57.
1990: D K Patneau; Mark L Mayer
Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(7):2385-99.
1990: Mark L Mayer; R J Miller
Excitatory amino acid receptors, second messengers and regulation of intracellular Ca2+ in mammalian neurons.
Trends in pharmacological sciences 1990;11(6):254-60.
1990: Morris J Benveniste; J M Mienville; E Sernagor; Mark L Mayer
Concentration-jump experiments with NMDA antagonists in mouse cultured hippocampal neurons.
Journal of neurophysiology 1990;63(6):1373-84.
1990: Mark L Mayer; L Vyklicky; D K Patneau
Glutamate receptors in cultures of mouse hippocampus studied with fast applications of agonists, modulators and drugs.
Advances in experimental medicine and biology 1990;268():3-11.
1989: Mark L Mayer; L Vyklicky
The action of zinc on synaptic transmission and neuronal excitability in cultures of mouse hippocampus.
The Journal of physiology 1989;415():351-65.
1989: Mark L Mayer; L Vyklicky; Gary L Westbrook
Modulation of excitatory amino acid receptors by group IIB metal cations in cultured mouse hippocampal neurones.
The Journal of physiology 1989;415():329-50.
1989: Mark L Mayer; L Vyklicky; J Clements
Regulation of NMDA receptor desensitization in mouse hippocampal neurons by glycine.
Nature 1989;338(6214):425-7.
1989: E Sernagor; D Kuhn; L Vyklicky; Mark L Mayer
Open channel block of NMDA receptor responses evoked by tricyclic antidepressants.
Neuron 1989;2(3):1221-7.
1989: Mark L Mayer; L Vyklicky
Concanavalin A selectively reduces desensitization of mammalian neuronal quisqualate receptors.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(4):1411-5.
1989: K Sugiyama; A Brunori; Mark L Mayer
Glial uptake of excitatory amino acids influences neuronal survival in cultures of mouse hippocampus.
Neuroscience 1989;32(3):779-91.
1988: I D Forsythe; Gary L Westbrook; Mark L Mayer
Modulation of excitatory synaptic transmission by glycine and zinc in cultures of mouse hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(10):3733-41.
1988: Mark L Mayer; Gary L Westbrook; L Vyklický
Sites of antagonist action on N-methyl-D-aspartic acid receptors studied using fluctuation analysis and a rapid perfusion technique.
Journal of neurophysiology 1988;60(2):645-63.
1988: Mark L Mayer; K Sugiyama
A modulatory action of divalent cations on transient outward current in cultured rat sensory neurones.
The Journal of physiology 1988;396():417-33.
1987: Mark L Mayer; Gary L Westbrook
Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurones.
The Journal of physiology 1987;394():501-27.
1987: Mark L Mayer; A B MacDermott; Gary L Westbrook; S J Smith; J L Barker
Agonist- and voltage-gated calcium entry in cultured mouse spinal cord neurons under voltage clamp measured using arsenazo III.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1987;7(10):3230-44.
1986: A B MacDermott; Mark L Mayer; Gary L Westbrook; S J Smith; J L Barker
NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones.
Nature 1986;321(6069):519-22.