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Craig McArdle

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Jason N A Pont; Craig A McArdle; Andrés López Bernal
Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
Craig A McArdle
Gonadotropin-releasing hormone receptor signaling: biased and unbiased.
Guadalupe Rivero; Elizabeth M Rosethorne; Chris P Bailey; Steven J Charlton; Alex Cooke; Graeme Henderson; Cornelius Krasel; Javier Llorente; Craig A McArdle; Jamie McPherson; Stuart J Mundell; Eamonn Kelly
Endomorphin-2: a biased agonist at the μ-opioid receptor.

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All Publications

2012: Jason N A Pont; Craig A McArdle; Andrés López Bernal
Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
Molecular endocrinology (Baltimore, Md.) 2012;26(10):1743-56.
2012: Craig A McArdle
Gonadotropin-releasing hormone receptor signaling: biased and unbiased.
Mini reviews in medicinal chemistry 2012;12(9):841-50.
2012: Guadalupe Rivero; Elizabeth M Rosethorne; Chris P Bailey; Steven J Charlton; Alex Cooke; Graeme Henderson; Cornelius Krasel; Javier Llorente; Craig A McArdle; Jamie McPherson; Stuart J Mundell; Eamonn Kelly
Endomorphin-2: a biased agonist at the μ-opioid receptor.
Molecular pharmacology 2012;82(2):178-88.
2012: Ann R Finch; Rebecca M Perrett; Krasimira Tsaneva-Atanasova; Christopher J Caunt; Craig A McArdle
Dual specificity phosphatases 10 and 16 are positive regulators of EGF-stimulated ERK activity: indirect regulation of ERK signals by JNK/p38 selective MAPK phosphatases.
Cellular signalling 2012;24(5):1002-11.
2012: Krasimira Tsaneva-Atanasova; Rebecca M Perrett; Stephen P Armstrong; Christopher J Caunt; Craig A McArdle
Decoding neurohormone pulse frequency by convergent signalling modules.
Biochemical Society transactions 2012;40(1):273-8.
2012: Christopher J Caunt; Craig A McArdle
ERK phosphorylation and nuclear accumulation: insights from single-cell imaging.
Biochemical Society transactions 2012;40(1):224-9.
2012: Krasimira Tsaneva-Atanasova; Petros Mina; Stephen P Armstrong; Christopher J Caunt; Craig A McArdle
Decoding GnRH neurohormone pulse frequency by convergent signalling modules.
Journal of the Royal Society, Interface / the Royal Society 2012;9(66):170-82.
2012: Christopher J Caunt; Robert C Fowkes; Rebecca M Perett; Craig A McArdle
Mechanisms of GnRH-induced extracellular signal-regulated kinase nuclear localization.
PloS one 2012;7(7):e40077.
2011: S P Armstrong; Christopher J Caunt; Ann R Finch; Craig A McArdle
Using automated imaging to interrogate gonadotrophin-releasing hormone receptor trafficking and function.
Molecular and cellular endocrinology 2011;331(2):194-204.
2010: J J Walker; John R Terry; Krasimira Tsaneva-Atanasova; S P Armstrong; Craig A McArdle; Stafford L Lightman
Encoding and decoding mechanisms of pulsatile hormone secretion.
Journal of neuroendocrinology 2010;22(12):1226-38.
2010: Gavin I Welsh; Lorna J Hale; Vera Eremina; Marie Jeansson; Yoshiro Maezawa; Rachel Lennon; Deborah A Pons; Rachel J Owen; Simon C Satchell; Mervyn J Miles; Christopher J Caunt; Craig A McArdle; Hermann Pavenstädt; Jeremy M Tavaré; Andrew M Herzenberg; C Ronald Kahn; Peter W Mathieson; Susan E Quaggin; Moin A Saleem; Richard J M Coward
Insulin signaling to the glomerular podocyte is critical for normal kidney function.
Cell metabolism 2010;12(4):329-40.
2010: Stephen P Armstrong; Christopher J Caunt; RC Fowkes; Krasimira Tsaneva-Atanasova; Craig A McArdle
Pulsatile and sustained gonadotropin-releasing hormone (GnRH) receptor signaling: does the ERK signaling pathway decode GnRH pulse frequency?
The Journal of biological chemistry 2010;285(32):24360-71.
2010: Ann R Finch; Christopher J Caunt; Stephen P Armstrong; Craig A McArdle
Plasma membrane expression of gonadotropin-releasing hormone receptors: regulation by peptide and nonpeptide antagonists.
Molecular endocrinology (Baltimore, Md.) 2010;24(2):423-35.
2010: Ann R Finch; Kathleen R Sedgley; S P Armstrong; Christopher J Caunt; Craig A McArdle
Trafficking and signalling of gonadotrophin-releasing hormone receptors: an automated imaging approach.
British journal of pharmacology 2010;159(4):751-60.
2010: Christopher J Caunt; Stephen P Armstrong; Craig A McArdle
Using high-content microscopy to study gonadotrophin-releasing hormone regulation of ERK.
Methods in molecular biology (Clifton, N.J.) 2010;661():507-24.
2009: Stephen P Armstrong; Christopher J Caunt; RC Fowkes; Krasimira Tsaneva-Atanasova; Craig A McArdle
Pulsatile and sustained gonadotropin-releasing hormone (GnRH) receptor signaling: does the Ca2+/NFAT signaling pathway decode GnRH pulse frequency?
The Journal of biological chemistry 2009;284(51):35746-57.
2009: Ann R Finch; Christopher J Caunt; Stephen P Armstrong; Craig A McArdle
Agonist-induced internalization and downregulation of gonadotropin-releasing hormone receptors.
American journal of physiology. Cell physiology 2009;297(3):C591-600.
2009: Stephen Paul Armstrong; Christopher J Caunt; Craig A McArdle
Gonadotropin-releasing hormone and protein kinase C signaling to ERK: spatiotemporal regulation of ERK by docking domains and dual-specificity phosphatases.
Molecular endocrinology (Baltimore, Md.) 2009;23(4):510-9.
2008: Christopher J Caunt; Stephen P Armstrong; Caroline A Rivers; Michael R Norman; Craig A McArdle
Spatiotemporal regulation of ERK2 by dual specificity phosphatases.
The Journal of biological chemistry 2008;283(39):26612-23.
2008: Christopher J Caunt; Caroline A Rivers; Becky L Conway-Campbell; Michael R Norman; Craig A McArdle
Epidermal growth factor receptor and protein kinase C signaling to ERK2: spatiotemporal regulation of ERK2 by dual specificity phosphatases.
The Journal of biological chemistry 2008;283(10):6241-52.
2008: Ann R Finch; Kathleen R Sedgley; Christopher J Caunt; Craig A McArdle
Plasma membrane expression of GnRH receptors: regulation by antagonists in breast, prostate, and gonadotrope cell lines.
The Journal of endocrinology 2008;196(2):353-67.
2006: Kathleen R Sedgley; Ann R Finch; Christopher J Caunt; Craig A McArdle
Intracellular gonadotropin-releasing hormone receptors in breast cancer and gonadotrope lineage cells.
The Journal of endocrinology 2006;191(3):625-36.
2006: Christopher J Caunt; Ann R Finch; Kathleen R Sedgley; Craig A McArdle
GnRH receptor signalling to ERK: kinetics and compartmentalization.
Trends in endocrinology and metabolism: TEM 2006;17(8):308-13.
2006: Christopher J Caunt; Ann R Finch; Kathleen R Sedgley; Craig A McArdle
Seven-transmembrane receptor signalling and ERK compartmentalization.
Trends in endocrinology and metabolism: TEM 2006;17(7):276-83.
2006: Christopher J Caunt; Ann R Finch; Kathleen R Sedgley; Lisa Oakley; Louis M Luttrell; Craig A McArdle
Arrestin-mediated ERK activation by gonadotropin-releasing hormone receptors: receptor-specific activation mechanisms and compartmentalization.
The Journal of biological chemistry 2006;281(5):2701-10.
2006: M P Smith; V J Ayad; Stuart J Mundell; Craig A McArdle; Eamonn Kelly; Andrés López Bernal
Internalization and desensitization of the oxytocin receptor is inhibited by Dynamin and clathrin mutants in human embryonic kidney 293 cells.
Molecular endocrinology (Baltimore, Md.) 2006;20(2):379-88.
2005: James N Hislop; Christopher J Caunt; Kathleen R Sedgley; Eammon Kelly; Stuart J Mundell; Lisa D Green; Craig A McArdle
Internalization of gonadotropin-releasing hormone receptors (GnRHRs): does arrestin binding to the C-terminal tail target GnRHRs for dynamin-dependent internalization?
Journal of molecular endocrinology 2005;35(1):177-89.
2004: Christopher J Caunt; James N Hislop; Eamonn Kelly; Anne-Lise Matharu; Lisa D Green; Kathleen R Sedgley; Ann R Finch; Craig A McArdle
Regulation of gonadotropin-releasing hormone receptors by protein kinase C: inside out signalling and evidence for multiple active conformations.
Endocrinology 2004;145(8):3594-602.
2004: Ann R Finch; Lisa Green; James N Hislop; Eamonn Kelly; Craig A McArdle
Signaling and antiproliferative effects of type I and II gonadotropin-releasing hormone receptors in breast cancer cells.
The Journal of clinical endocrinology and metabolism 2004;89(4):1823-32.
2003: J Franklin; James N Hislop; A Flynn; Craig A McArdle
Signalling and anti-proliferative effects mediated by gonadotrophin-releasing hormone receptors after expression in prostate cancer cells using recombinant adenovirus.
The Journal of endocrinology 2003;176(2):275-84.
2002: Craig A McArdle; J Franklin; Lisa Green; James N Hislop
The gonadotrophin-releasing hormone receptor: signalling, cycling and desensitisation.
Archives of physiology and biochemistry 2002;110(1-2):113-22.
2002: Craig A McArdle; J Franklin; Lisa Green; James N Hislop
Signalling, cycling and desensitisation of gonadotrophin-releasing hormone receptors.
The Journal of endocrinology 2002;173(1):1-11.
2001: Craig A McArdle; J J Evans
The circus in the pituitary.
Trends in endocrinology and metabolism: TEM 2001;12(10):429-30.
2001: HM Everest; James N Hislop; Tom Harding; James B Uney; A Flynn; Robert P Millar; Craig A McArdle
Signaling and antiproliferative effects mediated by GnRH receptors after expression in breast cancer cells using recombinant adenovirus.
Endocrinology 2001;142(11):4663-72.
2001: James N Hislop; HM Everest; A Flynn; Tom Harding; James B Uney; Brigitte E Troskie; Robert P Millar; Craig A McArdle
Differential internalization of mammalian and non-mammalian gonadotropin-releasing hormone receptors. Uncoupling of dynamin-dependent internalization from mitogen-activated protein kinase signaling.
The Journal of biological chemistry 2001;276(43):39685-94.
2001: Gary B Willars; J E Royall; Stefan R Nahorski; F El-Gehani; HM Everest; Craig A McArdle
Rapid down-regulation of the type I inositol 1,4,5-trisphosphate receptor and desensitization of gonadotropin-releasing hormone-mediated Ca2+ responses in alpha T3-1 gonadotropes.
The Journal of biological chemistry 2001;276(5):3123-9.
2000: James N Hislop; M T Madziva; HM Everest; Tom Harding; James B Uney; Gary B Willars; Robert P Millar; Brigitte E Troskie; James S Davidson; Craig A McArdle
Desensitization and internalization of human and xenopus gonadotropin-releasing hormone receptors expressed in alphaT4 pituitary cells using recombinant adenovirus.
Endocrinology 2000;141(12):4564-75.
2000: RC Fowkes; Craig A McArdle
C-type natriuretic peptide: an important neuroendocrine regulator?
Trends in endocrinology and metabolism: TEM 2000;11(8):333-8.
2000: RC Fowkes; W Forrest-Owen; Craig A McArdle
C-type natriuretic peptide (CNP) effects in anterior pituitary cell lines: evidence for homologous desensitisation of CNP-stimulated cGMP accumulation in alpha T3-1 gonadotroph-derived cells.
The Journal of endocrinology 2000;166(1):195-203.
2000: B Williams; M Bence; HM Everest; W Forrest-Owen; Stafford L Lightman; Craig A McArdle
GABAA receptor mediated elevation of Ca2+ and modulation of gonadotrophin-releasing hormone action in alphaT3-1 gonadotropes.
Journal of neuroendocrinology 2000;12(2):159-66.
2000: B Williams; AN Brooks; Tom Aldridge; William D Pennie; R Stephenson; Craig A McArdle
Oestradiol is a potent mitogen and modulator of GnRH signalling in alphaT3-1 cells: are these effects causally related?
The Journal of endocrinology 2000;164(1):31-43.
1999: D Assefa; Adam J Pawson; Craig A McArdle; Robert P Millar; Colleen A Flanagan; Roger W Roeske; James S Davidson
A new photoreactive antagonist cross-links to the N-terminal domain of the gonadotropin-releasing hormone receptor.
Molecular and cellular endocrinology 1999;156(1-2):179-88.
1999: RC Fowkes; W Forrest-Owen; B Williams; Craig A McArdle
C-type natriuretic peptide (CNP) effects on intracellular calcium [Ca2+]i in mouse gonadotrope-derived alphaT3-1 cell line.
Regulatory peptides 1999;84(1-3):43-9.
1999: Craig A McArdle; James S Davidson; Gary B Willars
The tail of the gonadotrophin-releasing hormone receptor: desensitization at, and distal to, G protein-coupled receptors.
Molecular and cellular endocrinology 1999;151(1-2):129-36.
1999: Sonia D Birkett; Jamie Y Jeremy; S M Watts; Nilima Shukla; Gianni Angelini; Craig A McArdle
Inhibition of intracellular Ca2+ mobilisation by low antiproliferative concentrations of thapsigargin in human vascular smooth-muscle cells.
Journal of cardiovascular pharmacology 1999;33(2):204-11.
1999: W Forrest-Owen; Gary B Willars; Stefan R Nahorski; D Assefa; James S Davidson; James N Hislop; Craig A McArdle
The lack of gonadotrophin-releasing hormone (GnRH) receptor desensitisation in alphaT3-1 cells is not due to GnRH receptor reserve or phosphatidylinositol 4,5-bis-phosphate pool size.
Molecular and cellular endocrinology 1999;147(1-2):161-73.
1998: Gary B Willars; Craig A McArdle; Stefan R Nahorski
Acute desensitization of phospholipase C-coupled muscarinic M3 receptors but not gonadotropin-releasing hormone receptors co-expressed in alphaT3-1 cells: implications for mechanisms of rapid desensitization.
The Biochemical journal 1998;333 ( Pt 2)():301-8.
1997: Craig A McArdle; W Forrest-Owen
Pituitary adenylate cyclase-activating polypeptide (PACAP) actions on alphaT3-1 gonadotrophs show desensitization.
Journal of neuroendocrinology 1997;9(12):893-901.
1997: John J Evans; W Forrest-Owen; Craig A McArdle
Oxytocin receptor-mediated activation of phosphoinositidase C and elevation of cytosolic calcium in the gonadotrope-derived alphaT3-1 cell line.
Endocrinology 1997;138(5):2049-55.
1996: Craig A McArdle
Functional interaction between gonadotropin-releasing hormone and PACAP in gonadotropes and alpha T3-1 cells.
Annals of the New York Academy of Sciences 1996;805():112-20; discussion 120-1.
1996: Craig A McArdle; Gary B Willars; R C Fowkes; Stefan R Nahorski; James S Davidson; W Forrest-Owen
Desensitization of gonadotropin-releasing hormone action in alphaT3-1 cells due to uncoupling of inositol 1,4,5-trisphosphate generation and Ca2+ mobilization.
The Journal of biological chemistry 1996;271(39):23711-7.
1996: Craig A McArdle; Raymond Counis
GnRH and PACAP action in gonadotropes: cross-talk between phosphoinositidase C and adenylyl cyclase mediated signaling pathways.
Trends in endocrinology and metabolism: TEM 1996;7(5):168-75.
1996: James S Davidson; Craig A McArdle; P Davies; R Elario; Colleen A Flanagan; Robert P Millar
Asn102 of the gonadotropin-releasing hormone receptor is a critical determinant of potency for agonists containing C-terminal glycinamide.
The Journal of biological chemistry 1996;271(26):15510-4.
1996: James S Davidson; Colleen A Flanagan; P D Davies; Janet Patricia Hapgood; D Myburgh; R Elario; Robert P Millar; W Forrest-Owen; Craig A McArdle
Incorporation of an additional glycosylation site enhances expression of functional human gonadotropin-releasing hormone receptor.
Endocrine 1996;4(3):207-12.
1996: M Kratzmeier; A Poch; Amal K Mukhopadhyay; Craig A McArdle
Selective translocation of non-conventional protein kinase C isoenzymes by gonadotropin-releasing hormone (GnRH) in the gonadotrope-derived alpha T3-1 cell line.
Molecular and cellular endocrinology 1996;118(1-2):103-11.
1996: Craig A McArdle; W Forrest-Owen; James S Davidson; R Fowkes; R Bunting; W T Mason; A Poch; M Kratzmeier
Ca2+ entry in gonadotrophs and alpha T3-1 cells: does store-dependent Ca2+ influx mediate gonadotrophin-releasing hormone action?
The Journal of endocrinology 1996;149(1):155-69.
1996: Z P Chen; M Kratzmeier; A Poch; S Xu; Craig A McArdle; Andy Levy; Amal K Mukhopadhyay; Stafford L Lightman
Effects of extracellular nucleotides in the pituitary: adenosine triphosphate receptor-mediated intracellular responses in gonadotrope-derived alpha T3-1 cells.
Endocrinology 1996;137(1):248-56.
1995: Craig A McArdle; W Forrest-Owen; Gary B Willars; J Davidson; A Poch; M Kratzmeier
Desensitization of gonadotropin-releasing hormone action in the gonadotrope-derived alpha T3-1 cell line.
Endocrinology 1995;136(11):4864-71.
1995: Z P Chen; M Kratzmeier; Andy Levy; Craig A McArdle; A Poch; A Day; Amal K Mukhopadhyay; Stafford L Lightman
Evidence for a role of pituitary ATP receptors in the regulation of pituitary function.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):5219-23.
1994: Craig A McArdle; James Olcese; C Schmidt; A Poch; M Kratzmeier; Ralf Middendorff
C-type natriuretic peptide (CNP) in the pituitary: is CNP an autocrine regulator of gonadotropes?
Endocrinology 1994;135(6):2794-801.
1994: Z P Chen; Andy Levy; Craig A McArdle; Stafford L Lightman
Pituitary ATP receptors: characterization and functional localization to gonadotropes.
Endocrinology 1994;135(3):1280-3.
1994: Craig A McArdle; A Poch; E Schomerus; M Kratzmeier
Pituitary adenylate cyclase-activating polypeptide effects in pituitary cells: modulation by gonadotropin-releasing hormone in alpha T3-1 cells.
Endocrinology 1994;134(6):2599-605.
1994: James Olcese; Ralf Middendorff; M Münker; C Schmidt; Craig A McArdle
Natriuretic peptides stimulate cyclic GMP production in an immortalized LHRH neuronal cell line.
Journal of neuroendocrinology 1994;6(2):127-30.
1994: E Schomerus; A Poch; R Bunting; W T Mason; Craig A McArdle
Effects of pituitary adenylate cyclase-activating polypeptide in the pituitary: activation of two signal transduction pathways in the gonadotrope-derived alpha T3-1 cell line.
Endocrinology 1994;134(1):315-23.
1993: Craig A McArdle; A Poch; K Käppler
Cyclic guanosine monophosphate production in the pituitary: stimulation by C-type natriuretic peptide and inhibition by gonadotropin-releasing hormone in alpha T3-1 cells.
Endocrinology 1993;132(5):2065-72.
1992: Craig A McArdle; E Schomerus; I Gröner; A Poch
Estradiol regulates gonadotropin-releasing hormone receptor number, growth and inositol phosphate production in alpha T3-1 cells.
Molecular and cellular endocrinology 1992;87(1-3):95-103.
1992: Craig A McArdle; A Poch
Dependence of gonadotropin-releasing hormone-stimulated luteinizing hormone release upon intracellular Ca2+ pools is revealed by desensitization and thapsigargin blockade.
Endocrinology 1992;130(6):3567-74.
1991: Craig A McArdle; C Kohl; K Rieger; I Gröner; U Wehrenberg
Effects of gonadotropins, insulin and insulin-like growth factor I on ovarian oxytocin and progesterone production.
Molecular and cellular endocrinology 1991;78(3):211-20.
1991: Craig A McArdle; E J Cragoe; A Poch
Na+ dependence of gonadotropin-releasing hormone action: characterization of the Na+/H+ antiport in pituitary gonadotropes.
Endocrinology 1991;128(2):771-8.
1990: Craig A McArdle
Chronic regulation of ovarian oxytocin and progesterone release by prostaglandins: opposite effects in bovine granulosa and early luteal cells.
The Journal of endocrinology 1990;126(2):245-53.
1989: Anke-Peggy Holtorf; K Furuya; Richard Ivell; Craig A McArdle
Oxytocin production and oxytocin messenger ribonucleic acid levels in bovine granulosa cells are regulated by insulin and insulin-like growth factor-I: dependence on developmental status of the ovarian follicle.
Endocrinology 1989;125(5):2612-20.
1989: Craig A McArdle; Anke-Peggy Holtorf
Oxytocin and progesterone release from bovine corpus luteal cells in culture: effects of insulin-like growth factor I, insulin, and prostaglandins.
Endocrinology 1989;124(3):1278-86.