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John McAvoy

Research Profile

Anatomy

Living Beings

Physiology

Chemicals & Drugs

Disorders

Cataract

Phenomena

Procedures

Organ Culture Techniques

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Publications

TOP 3
Jingjing You; Li Wen; Chris Hodge; Michele C Madigan; John W McAvoy; Gerard Sutton
Tear levels of SFRP1 are significantly reduced in keratoconus patients.
Lucy J Dawes; Frank J Lovicu; Yuki Sugiyama; Ana S Tanedo; John W McAvoy
Wnt-frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation.
Jingjing You; Li Wen; Chris Hodge; Michele C Madigan; John W McAvoy; Gerard Sutton
Using soybean trypsin inhibitor as an external loading control for Western blot analysis of tear proteins: application to corneal disease.

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All Publications

2013: Jingjing You; Li Wen; Chris Hodge; Michele C Madigan; John W McAvoy; Gerard Sutton
Tear levels of SFRP1 are significantly reduced in keratoconus patients.
Molecular vision 2013;19():509-xxx.
2013: Lucy J Dawes; Frank J Lovicu; Yuki Sugiyama; Ana S Tanedo; John W McAvoy
Wnt-frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation.
Investigative ophthalmology & visual science 2013;54(3):1582-90.
2012: Jingjing You; Li Wen; Chris Hodge; Michele C Madigan; John W McAvoy; Gerard Sutton
Using soybean trypsin inhibitor as an external loading control for Western blot analysis of tear proteins: application to corneal disease.
Experimental eye research 2012;99():55-62.
2012: Eun Hye H Shin; M Albert Basson; John W McAvoy; Michael L Robinson; Frank J Lovicu
Sprouty is a negative regulator of transforming growth factor β-induced epithelial-to-mesenchymal transition and cataract.
Molecular medicine (Cambridge, Mass.) 2012;18():861-73.
2011: Yuki Sugiyama; Frank J Lovicu; John W McAvoy
Planar cell polarity in the mammalian eye lens.
Organogenesis 2011;7(3):191-201.
2011: Georgios Kallifatidis; Jessica Boros; Eun Hye H Shin; John W McAvoy; Frank J Lovicu
The fate of dividing cells during lens morphogenesis, differentiation and growth.
Experimental eye research 2011;92(6):502-11.
2011: Frank J Lovicu; John W McAvoy; Robbert U de Iongh
Understanding the role of growth factors in embryonic development: insights from the lens.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2011;366(1568):1204-18.
2010: Peter Newitt; Jessica Boros; Bhavani P Madakashira; Michael L Robinson; Lixing W Reneker; John W McAvoy; Frank J Lovicu
Sef is a negative regulator of fiber cell differentiation in the ocular lens.
Differentiation; research in biological diversity 2010;80(1):53-67.
2010: Yuki Sugiyama; R J W Stump; Anke Nguyen; Li Wen; Yongjuan Chen; Yanshu Wang; Jennifer N Murdoch; Frank J Lovicu; John W McAvoy
Secreted frizzled-related protein disrupts PCP in eye lens fiber cells that have polarised primary cilia.
Developmental biology 2010;338(2):193-201.
2009: Shiwani Sharma; Katrina S Y Koh; Caitlin Collin; Alpana Dave; Amy McMellon; Yuki Sugiyama; John W McAvoy; Anne K Voss; Jozef Gecz; Jamie E Craig
NHS-A isoform of the NHS gene is a novel interactor of ZO-1.
Experimental cell research 2009;315(14):2358-72.
2009: Qian Wang; Richard Stump; John W McAvoy; Frank J Lovicu
MAPK/ERK1/2 and PI3-kinase signalling pathways are required for vitreous-induced lens fibre cell differentiation.
Experimental eye research 2009;88(2):293-306.
2009: C C W Chong; R J W Stump; Frank J Lovicu; John W McAvoy
TGFbeta promotes Wnt expression during cataract development.
Experimental eye research 2009;88(2):307-13.
2008: Yongjuan Chen; R J W Stump; Frank J Lovicu; Akihiko Shimono; John W McAvoy
Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture.
Developmental biology 2008;324(1):161-76.
2008: Michael D O'Connor; Elizabeth D Wederell; Robbert U de Iongh; Frank J Lovicu; John W McAvoy
Generation of transparency and cellular organization in lens explants.
Experimental eye research 2008;86(5):734-45.
2007: Robyn V Jamieson; Nicola Farrar; Katrina Stewart; Rahat Perveen; Marija Mihelec; Martin Carette; John R Grigg; John W McAvoy; Frank J Lovicu; Patrick P L Tam; Peter J Scambler; Christopher Lloyd; Dian Donnai; Graeme C M Black
Characterization of a familial t(16;22) balanced translocation associated with congenital cataract leads to identification of a novel gene, TMEM114, expressed in the lens and disrupted by the translocation.
Human mutation 2007;28(10):968-77.
2007: Laxmi Iyengar; Qian Wang; John Rasko; John W McAvoy; Frank J Lovicu
Duration of ERK1/2 phosphorylation induced by FGF or ocular media determines lens cell fate.
Differentiation; research in biological diversity 2007;75(7):662-8.
2007: Michael D O'Connor; John W McAvoy
In vitro generation of functional lens-like structures with relevance to age-related nuclear cataract.
Investigative ophthalmology & visual science 2007;48(3):1245-52.
2007: David J Pennisi; Lorine Wilkinson; Gabriel Kolle; Michael L Sohaskey; Kevin Gillinder; Michael Piper; John W McAvoy; Frank J Lovicu; Melissa H Little
Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(2):502-11.
2006: Yongjuan Chen; R J W Stump; Frank J Lovicu; John W McAvoy
A role for Wnt/planar cell polarity signaling during lens fiber cell differentiation?
Seminars in cell & developmental biology 2006;17(6):712-25.
2006: Jessica Boros; Peter Newitt; Qian Wang; John W McAvoy; Frank J Lovicu
Sef and Sprouty expression in the developing ocular lens: implications for regulating lens cell proliferation and differentiation.
Seminars in cell & developmental biology 2006;17(6):741-52.
2006: R J W Stump; Frank J Lovicu; S L Ang; Suresh K Pandey; John W McAvoy
Lithium stabilizes the polarized lens epithelial phenotype and inhibits proliferation, migration, and epithelial mesenchymal transition.
The Journal of pathology 2006;210(2):249-57.
2006: Laxmi Iyengar; Bramilla Patkunanathan; Oonagh T Lynch; John W McAvoy; John Rasko; Frank J Lovicu
Aqueous humour- and growth factor-induced lens cell proliferation is dependent on MAPK/ERK1/2 and Akt/PI3-K signalling.
Experimental eye research 2006;83(3):667-78.
2006: Shiwani Sharma; Sharyn L Ang; Marie Shaw; David A Mackey; Jozef Gécz; John W McAvoy; Jamie E Craig
Nance-Horan syndrome protein, NHS, associates with epithelial cell junctions.
Human molecular genetics 2006;15(12):1972-83.
2006: Lavinia Taliana; Margaret D M Evans; Sharyn Ang; John W McAvoy
Vitronectin is present in epithelial cells of the intact lens and promotes epithelial mesenchymal transition in lens epithelial explants.
Molecular vision 2006;12():1233-42.
2005: Elizabeth D Wederell; Heidi Brown; Michael O'connor; Coral G Chamberlain; John W McAvoy; Robbert U de Iongh
Laminin-binding integrins in rat lens morphogenesis and their regulation during fibre differentiation.
Experimental eye research 2005;81(3):326-39.
2005: Frank J Lovicu; John W McAvoy
Growth factor regulation of lens development.
Developmental biology 2005;280(1):1-14.
2005: Robbert U de Iongh; Elizabeth D Wederell; Frank J Lovicu; John W McAvoy
Transforming growth factor-beta-induced epithelial-mesenchymal transition in the lens: a model for cataract formation.
Cells, tissues, organs 2005;179(1-2):43-55.
2004: Robbert U de Iongh; Yongjuan Chen; Maria I Kokkinos; John W McAvoy
BMP and activin receptor expression in lens development.
Molecular vision 2004;10():566-76.
2004: Frank J Lovicu; Philipp Steven; Shizuya Saika; John W McAvoy
Aberrant lens fiber differentiation in anterior subcapsular cataract formation: a process dependent on reduced levels of Pax6.
Investigative ophthalmology & visual science 2004;45(6):1946-53.
2004: Sharyn Ang; R J W Stump; Frank J Lovicu; John W McAvoy
Spatial and temporal expression of Wnt and Dickkopf genes during murine lens development.
Gene expression patterns : GEP 2004;4(3):289-95.
2004: Frank J Lovicu; S Ang; M Chorazyczewska; John W McAvoy
Deregulation of lens epithelial cell proliferation and differentiation during the development of TGFbeta-induced anterior subcapsular cataract.
Developmental neuroscience 2004;26(5-6):446-55.
2004: Yongjuan Chen; R J W Stump; Frank J Lovicu; John W McAvoy
Expression of Frizzleds and secreted frizzled-related proteins (Sfrps) during mammalian lens development.
The International journal of developmental biology 2004;48(8-9):867-77.
2003: R J W Stump; Sharyn Ang; Yongjuan Chen; Tatiana von Bahr; Frank J Lovicu; Kathleen Pinson; Robbert U de Iongh; Terry P Yamaguchi; David A Sassoon; John W McAvoy
A role for Wnt/beta-catenin signaling in lens epithelial differentiation.
Developmental biology 2003;259(1):48-61.
2002: Alison Kok; Frank J Lovicu; Coral G Chamberlain; John W McAvoy
Influence of platelet-derived growth factor on lens epithelial cell proliferation and differentiation.
Growth factors (Chur, Switzerland) 2002;20(1):27-34.
2002: Kevin A Maruno; Frank J Lovicu; Coral G Chamberlain; John W McAvoy
Apoptosis is a feature of TGF beta-induced cataract.
Clinical & experimental optometry : journal of the Australian Optometrical Association 2002;85(2):76-82.
2002: Frank J Lovicu; Mark W Schulz; Angela M Hales; Lisa N Vincent; Paul A Overbeek; Coral G Chamberlain; John W McAvoy
TGFbeta induces morphological and molecular changes similar to human anterior subcapsular cataract.
The British journal of ophthalmology 2002;86(2):220-6.
2001: Frank J Lovicu; John W McAvoy
FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/2) signalling.
Development (Cambridge, England) 2001;128(24):5075-84.
2001: Robbert U de Iongh; Frank J Lovicu; Paul A Overbeek; M D Schneider; J Joya; E D Hardeman; John W McAvoy
Requirement for TGFbeta receptor signaling during terminal lens fiber differentiation.
Development (Cambridge, England) 2001;128(20):3995-4010.
2001: Robbert U de Iongh; Clare Gordon-Thomson; Coral G Chamberlain; Angela M Hales; John W McAvoy
Tgfbeta receptor expression in lens: implications for differentiation and cataractogenesis.
Experimental eye research 2001;72(6):649-59.
2000: Angela M Hales; Coral G Chamberlain; John W McAvoy
Susceptibility to TGFbeta2-induced cataract increases with aging in the rat.
Investigative ophthalmology & visual science 2000;41(11):3544-51.
2000: John W McAvoy; Coral G Chamberlain; Robbert U de Iongh; Angela M Hales; Frank J Lovicu
Peter Bishop Lecture: growth factors in lens development and cataract: key roles for fibroblast growth factor and TGF-beta.
Clinical & experimental ophthalmology 2000;28(3):133-9.
2000: Y Ueda; Coral G Chamberlain; K Satoh; John W McAvoy
Inhibition of FGF-induced alphaA-crystallin promoter activity in lens epithelial explants by TGFbeta.
Investigative ophthalmology & visual science 2000;41(7):1833-9.
2000: Frank J Lovicu; Gabriel Kolle; Toshiya Yamada; Melissa H Little; John W McAvoy
Expression of Crim1 during murine ocular development.
Mechanisms of development 2000;94(1-2):261-5.
1999: Angela M Hales; Coral G Chamberlain; Bogdan Dreher; John W McAvoy
Intravitreal injection of TGFbeta induces cataract in rats.
Investigative ophthalmology & visual science 1999;40(13):3231-6.
1999: Frank J Lovicu; John W McAvoy
Spatial and temporal expression of p57(KIP2) during murine lens development.
Mechanisms of development 1999;86(1-2):165-9.
1999: John W McAvoy; Coral G Chamberlain; Robbert U de Iongh; Angela M Hales; Frank J Lovicu
Lens development.
Eye (London, England) 1999;13 ( Pt 3b)():425-37.
1998: E j Klok; N H Lubsen; Coral G Chamberlain; John W McAvoy
Induction and maintenance of differentiation of rat lens epithelium by FGF-2, insulin and IGF-1.
Experimental eye research 1998;67(4):425-31.
1998: Clare Gordon-Thomson; Robbert U de Iongh; Angela M Hales; Coral G Chamberlain; John W McAvoy
Differential cataractogenic potency of TGF-beta1, -beta2, and -beta3 and their expression in the postnatal rat eye.
Investigative ophthalmology & visual science 1998;39(8):1399-409.
1997: Robbert U de Iongh; Frank J Lovicu; Coral G Chamberlain; John W McAvoy
Differential expression of fibroblast growth factor receptors during rat lens morphogenesis and growth.
Investigative ophthalmology & visual science 1997;38(9):1688-99.
1997: Frank J Lovicu; Robbert U de Iongh; John W McAvoy
Expression of FGF-1 and FGF-2 mRNA during lens morphogenesis, differentiation and growth.
Current eye research 1997;16(3):222-30.
1997: Angela M Hales; Coral G Chamberlain; C R Murphy; John W McAvoy
Estrogen protects lenses against cataract induced by transforming growth factor-beta (TGFbeta).
The Journal of experimental medicine 1997;185(2):273-80.
1997: M W Schulz; Coral G Chamberlain; John W McAvoy
Binding of FGF-1 and FGF-2 to heparan sulphate proteoglycans of the mammalian lens capsule.
Growth factors (Chur, Switzerland) 1997;14(1):1-13.
1996: J Liu; Coral G Chamberlain; John W McAvoy
IGF enhancement of FGF-induced fibre differentiation and DNA synthesis in lens explants.
Experimental eye research 1996;63(6):621-9.
1996: Robbert U de Iongh; Frank J Lovicu; A Hanneken; A Baird; John W McAvoy
FGF receptor-1 (flg) expression is correlated with fibre differentiation during rat lens morphogenesis and growth.
Developmental dynamics : an official publication of the American Association of Anatomists 1996;206(4):412-26.
1996: M W Schulz; Coral G Chamberlain; John W McAvoy
Inhibition of transforming growth factor-beta-induced cataractous changes in lens explants by ocular media and alpha 2-macroglobulin.
Investigative ophthalmology & visual science 1996;37(8):1509-19.
1995: Angela M Hales; Coral G Chamberlain; John W McAvoy
Cataract induction in lenses cultured with transforming growth factor-beta.
Investigative ophthalmology & visual science 1995;36(8):1709-13.
1995: Frank J Lovicu; Coral G Chamberlain; John W McAvoy
Differential effects of aqueous and vitreous on fiber differentiation and extracellular matrix accumulation in lens epithelial explants.
Investigative ophthalmology & visual science 1995;36(7):1459-69.
1994: Angela M Hales; M W Schulz; Coral G Chamberlain; John W McAvoy
TGF-beta 1 induces lens cells to accumulate alpha-smooth muscle actin, a marker for subcapsular cataracts.
Current eye research 1994;13(12):885-90.
1994: J Liu; Angela M Hales; Coral G Chamberlain; John W McAvoy
Induction of cataract-like changes in rat lens epithelial explants by transforming growth factor beta.
Investigative ophthalmology & visual science 1994;35(2):388-401.
1993: N A Richardson; Coral G Chamberlain; John W McAvoy
IGF-1 enhancement of FGF-induced lens fiber differentiation in rats of different ages.
Investigative ophthalmology & visual science 1993;34(12):3303-12.
1993: Frank J Lovicu; John W McAvoy
Localization of acidic fibroblast growth factor, basic fibroblast growth factor, and heparan sulphate proteoglycan in rat lens: implications for lens polarity and growth patterns.
Investigative ophthalmology & visual science 1993;34(12):3355-65.
1993: Robbert U de Iongh; John W McAvoy
Spatio-temporal distribution of acidic and basic FGF indicates a role for FGF in rat lens morphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 1993;198(3):190-202.
1993: M W Schulz; Coral G Chamberlain; Robbert U de Iongh; John W McAvoy
Acidic and basic FGF in ocular media and lens: implications for lens polarity and growth patterns.
Development (Cambridge, England) 1993;118(1):117-26.
1992: N A Richardson; John W McAvoy; Coral G Chamberlain
Age of rats affects response of lens epithelial explants to fibroblast growth factor.
Experimental eye research 1992;55(5):649-56.
1992: R Peek; John W McAvoy; Nicolette H Lubsen; J G Schoenmakers
Rise and fall of crystallin gene messenger levels during fibroblast growth factor induced terminal differentiation of lens cells.
Developmental biology 1992;152(1):152-60.
1992: Frank J Lovicu; John W McAvoy
The age of rats affects the response of lens epithelial explants to fibroblast growth factor. An ultrastructural analysis.
Investigative ophthalmology & visual science 1992;33(7):2269-78.
1992: Robbert U de Iongh; John W McAvoy
Distribution of acidic and basic fibroblast growth factors (FGF) in the foetal rat eye: implications for lens development.
Growth factors (Chur, Switzerland) 1992;6(2):159-77.
1991: C M Parmigiani; John W McAvoy
The roles of laminin and fibronectin in the development of the lens capsule.
Current eye research 1991;10(6):501-11.
1991: Coral G Chamberlain; John W McAvoy; N A Richardson
The effects of insulin and basic fibroblast growth factor on fibre differentiation in rat lens epithelial explants.
Growth factors (Chur, Switzerland) 1991;4(3):183-8.
1991: John W McAvoy; Coral G Chamberlain; Robbert U de Iongh; N A Richardson; Frank J Lovicu
The role of fibroblast growth factor in eye lens development.
Annals of the New York Academy of Sciences 1991;638():256-74.
1990: N A Richardson; John W McAvoy
Age-related changes in fibre differentiation of rat lens epithelial explants exposed to fibroblast growth factor.
Experimental eye research 1990;50(2):203-11.
1990: John W McAvoy; Coral G Chamberlain
Growth factors in the eye.
Progress in growth factor research 1990;2(1):29-43.
1989: N A Richardson; John W McAvoy
An enzyme-linked immunosorbent assay for the quantitation of DNA.
Journal of immunological methods 1989;125(1-2):287-9.
1989: C M Parmigiani; John W McAvoy
A morphometric analysis of the development of the rat lens capsule.
Current eye research 1989;8(12):1271-7.
1989: John W McAvoy; Coral G Chamberlain
Fibroblast growth factor (FGF) induces different responses in lens epithelial cells depending on its concentration.
Development (Cambridge, England) 1989;107(2):221-8.
1989: Frank J Lovicu; John W McAvoy
Structural analysis of lens epithelial explants induced to differentiate into fibres by fibroblast growth factor (FGF).
Experimental eye research 1989;49(3):479-94.
1989: Coral G Chamberlain; John W McAvoy
Induction of lens fibre differentiation by acidic and basic fibroblast growth factor (FGF).
Growth factors (Chur, Switzerland) 1989;1(2):125-34.
1988: John W McAvoy
Cell lineage analysis of lens epithelial cells induced to differentiate into fibres.
Experimental eye research 1988;47(6):869-83.
1988: N A Richardson; John W McAvoy
Age-related changes in fibre differentiation of rat lens epithelial cells in vitro.
Experimental eye research 1988;46(2):259-67.
1987: Coral G Chamberlain; John W McAvoy
Evidence that fibroblast growth factor promotes lens fibre differentiation.
Current eye research 1987;6(9):1165-9.
1986: N A Richardson; John W McAvoy
Analysis of an inductive interaction between lens and neural retina in rats of different ages.
Experimental eye research 1986;43(6):1031-42.
1986: John W McAvoy; N A Richardson
Nuclear pyknosis during lens fibre differentiation in epithelial explants.
Current eye research 1986;5(9):711-5.