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Gerd Bauerschmitz

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Daniel T Rein; Thomas Schöndorf; Anne Volkmer; Anne Kathrin Welter; Dirk Bauerschlag; Gerd J Bauerschmitz; Ines M Beyer; Markus C Fleisch; Wolfgang Janni; Martina Breidenbach
Combination of a MDR1-targeted replicative adenovirus and chemotherapy for the therapy of pretreated ovarian cancer.
Daniel T Rein; Anne Volkmer; Stephan E Baldus; Gerd J Bauerschmitz; Ines M Beyer; David T Curiel; Anca Dragoi; Alexandra P Hess; Wolfgang Janni; Nicolai Maass; Martina Breidenbach
Treatment of chemotherapy resistant ovarian cancer with a MDR1 targeted oncolytic adenovirus.
O Hemminki; Gerd J Bauerschmitz; S Hemmi; S Lavilla-Alonso; I Diaconu; Kilian Guse; Antti Koski; Renee A Desmond; M Lappalainen; Anna Kanerva; Vincenzo Cerullo; S Pesonen; Akseli Hemminki
Oncolytic adenovirus based on serotype 3.

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All Publications

2012: Daniel T Rein; Thomas Schöndorf; Anne Volkmer; Anne Kathrin Welter; Dirk Bauerschlag; Gerd J Bauerschmitz; Ines M Beyer; Markus C Fleisch; Wolfgang Janni; Martina Breidenbach
Combination of a MDR1-targeted replicative adenovirus and chemotherapy for the therapy of pretreated ovarian cancer.
Journal of cancer research and clinical oncology 2012;138(4):603-10.
2011: Daniel T Rein; Anne Volkmer; Stephan E Baldus; Gerd J Bauerschmitz; Ines M Beyer; David T Curiel; Anca Dragoi; Alexandra P Hess; Wolfgang Janni; Nicolai Maass; Martina Breidenbach
Treatment of chemotherapy resistant ovarian cancer with a MDR1 targeted oncolytic adenovirus.
Gynecologic oncology 2011;123(1):138-46.
2011: O Hemminki; Gerd J Bauerschmitz; S Hemmi; S Lavilla-Alonso; I Diaconu; Kilian Guse; Antti Koski; Renee A Desmond; M Lappalainen; Anna Kanerva; Vincenzo Cerullo; S Pesonen; Akseli Hemminki
Oncolytic adenovirus based on serotype 3.
Cancer gene therapy 2011;18(4):288-96.
2010: S Pesonen; P Nokisalmi; Sophie Escutenaire; Merja Särkioja; Mari Raki; Vincenzo Cerullo; Lotta Kangasniemi; Leena Laasonen; Camilla Ribacka; Kilian Guse; E Haavisto; M Oksanen; Maria Rajecki; A Helminen; Ari Ristimäki; A Karioja-Kallio; E Karli; T Kantola; Gerd J Bauerschmitz; Anna Kanerva; Timo Joensuu; Akseli Hemminki
Prolonged systemic circulation of chimeric oncolytic adenovirus Ad5/3-Cox2L-D24 in patients with metastatic and refractory solid tumors.
Gene therapy 2010;17(7):892-904.
2010: Iulia Diaconu; Vincenzo Cerullo; Sophie Escutenaire; Anna Kanerva; Gerd J Bauerschmitz; Ruben Hernandez-Alcoceba; Sari Pesonen; Akseli Hemminki
Human adenovirus replication in immunocompetent Syrian hamsters can be attenuated with chlorpromazine or cidofovir.
The journal of gene medicine 2010;12(5):435-45.
2010: Sergio Lavilla-Alonso; Gerd J Bauerschmitz; Usama Abo Ramadan; Juha Halavaara; Sophie Escutenaire; Iulia Diaconu; Turgut Tatlisumak; Anna Kanerva; Akseli Hemminki; Sari Pesonen
Adenoviruses with an αvβ integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases.
Journal of translational medicine 2010;8():80.
2009: Iulia Diaconu; Laura Denby; Sari Pesonen; Vincenzo Cerullo; Gerd J Bauerschmitz; Kilian Guse; Maria Rajecki; João D Dias; Kimmo Taari; Anna Kanerva; Andrew H Baker; Akseli Hemminki
Serotype chimeric and fiber-mutated adenovirus Ad5/19p-HIT for targeting renal cancer and untargeting the liver.
Human gene therapy 2009;20(6):611-20.
2008: Gerd J Bauerschmitz; Tuuli Ranki; Lotta Kangasniemi; Camilla Ribacka; Minna Eriksson; Marius Porten; Isabell Herrmann; Ari Ristimäki; Pekka Virkkunen; Maija Tarkkanen; Tanja Hakkarainen; Anna Kanerva; Daniel Rein; Sari Pesonen; Akseli Hemminki
Tissue-specific promoters active in CD44+CD24-/low breast cancer cells.
Cancer research 2008;68(14):5533-9.
2008: Anna Kanerva; Sergio Lavilla-Alonso; Mari Raki; Lotta Kangasniemi; Gerd J Bauerschmitz; Koichi Takayama; Ari Ristimäki; Renee A Desmond; Akseli Hemminki
Systemic therapy for cervical cancer with potentially regulatable oncolytic adenoviruses.
PloS one 2008;3(8):e2917.
2007: Minna Eriksson; Kilian Guse; Gerd J Bauerschmitz; Pekka Virkkunen; Maija Tarkkanen; Minna Tanner; Tanja Hakkarainen; Anna Kanerva; Renee A Desmond; Sari Pesonen; Akseli Hemminki
Oncolytic adenoviruses kill breast cancer initiating CD44+CD24-/low cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(12):2088-93.
2007: Mari Raki; Tanja Hakkarainen; Gerd J Bauerschmitz; Merja Särkioja; Renee A Desmond; Anna Kanerva; Akseli Hemminki
Utility of TK/GCV in the context of highly effective oncolysis mediated by a serotype 3 receptor targeted oncolytic adenovirus.
Gene therapy 2007;14(19):1380-8.
2007: Kilian Guse; J D Dias; Gerd J Bauerschmitz; Tanja Hakkarainen; Einari Aavik; Tuuli Ranki; T Pisto; Merja Särkioja; Renee A Desmond; Anna Kanerva; Akseli Hemminki
Luciferase imaging for evaluation of oncolytic adenovirus replication in vivo.
Gene therapy 2007;14(11):902-11.
2006: Gerd J Bauerschmitz; Kilian Guse; Anna Kanerva; Artur Menzel; Isabell Herrmann; Renee A Desmond; Masato Yamamoto; Dirk M Nettelbeck; Tanja Hakkarainen; Peter Dall; David T Curiel; Akseli Hemminki
Triple-targeted oncolytic adenoviruses featuring the cox2 promoter, E1A transcomplementation, and serotype chimerism for enhanced selectivity for ovarian cancer cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(2):164-74.
2006: Mariam A Stoff-Khalili; Angel A Rivera; Long P Le; Alexander Stoff; Maaike Everts; Juan L Contreras; D Chen; L Teng; Marianne G Rots; Hidde J Haisma; Rodney P Rocconi; Gerd J Bauerschmitz; Daniel T Rein; Masato Yamamoto; Gene P Siegal; Peter Dall; J Michael Mathis; David T Curiel
Employment of liver tissue slice analysis to assay hepatotoxicity linked to replicative and nonreplicative adenoviral agents.
Cancer gene therapy 2006;13(6):606-18.
2005: Mariam A Stoff-Khalili; Angel A Rivera; Joel N Glasgow; Long P Le; Alexander Stoff; Maaike Everts; Yuko Tsuruta; Yosuke Kawakami; Gerd J Bauerschmitz; J Michael Mathis; Larisa Pereboeva; G P Seigal; Peter Dall; David T Curiel
A human adenoviral vector with a chimeric fiber from canine adenovirus type 1 results in novel expanded tropism for cancer gene therapy.
Gene therapy 2005;12(23):1696-706.
2005: Daniel T Rein; Martina Breidenbach; Tyler O Kirby; Tie Han; Gene P Siegal; Gerd J Bauerschmitz; Minghui Wang; Dirk M Nettelbeck; Yuko Tsuruta; Masato Yamamoto; Peter Dall; Akseli Hemminki; David T Curiel
A fiber-modified, secretory leukoprotease inhibitor promoter-based conditionally replicating adenovirus for treatment of ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(3):1327-35.
2005: Peter Dall; Isabell Herrmann; Bettina Durst; Mariam A Stoff-Khalili; Gerd J Bauerschmitz; Bettina Hanstein; Dieter Niederacher
In vivo cervical cancer growth inhibition by genetically engineered cytotoxic T cells.
Cancer immunology, immunotherapy : CII 2005;54(1):51-60.
2004: John T Lam; Anna Kanerva; Gerd J Bauerschmitz; Koichi Takayama; Kaori Suzuki; Masato Yamamoto; Snehal M Bhoola; Bin Liu; Minghui Wang; Mack N Barnes; Ronald D Alvarez; Gene P Siegal; David T Curiel; Akseli Hemminki
Inter-patient variation in efficacy of five oncolytic adenovirus candidates for ovarian cancer therapy.
The journal of gene medicine 2004;6(12):1333-42.
2004: Daniel T Rein; Martina Breidenbach; Dirk M Nettelbeck; Yosuke Kawakami; Gene P Siegal; Warner K Huh; Minghui Wang; Akseli Hemminki; Gerd J Bauerschmitz; Masato Yamamoto; Yasuo Adachi; Koichi Takayama; Peter Dall; David T Curiel
Evaluation of tissue-specific promoters in carcinomas of the cervix uteri.
The journal of gene medicine 2004;6(11):1281-9.
2004: Gerd J Bauerschmitz; Anna Kanerva; Minghui Wang; Isabell Herrmann; Denise R Shaw; Theresa V Strong; Renee A Desmond; Daniel T Rein; Peter Dall; David T Curiel; Akseli Hemminki
Evaluation of a selectively oncolytic adenovirus for local and systemic treatment of cervical cancer.
International journal of cancer. Journal international du cancer 2004;111(2):303-9.
2004: Gerd J Bauerschmitz; Akseli Hemminki; D T Curiel; Peter Dall
[Tumour-dependent replicating adenoviruses in the treatment of carcinomas].
Zentralblatt für Gynäkologie 2004;126(4):280-1.
2004: Joel N Glasgow; Gerd J Bauerschmitz; David T Curiel; Akseli Hemminki
Transductional and transcriptional targeting of adenovirus for clinical applications.
Current gene therapy 2004;4(1):1-14.
2004: Anna Kanerva; Gerd J Bauerschmitz; Masato Yamamoto; John T Lam; Ronald D Alvarez; Gene P Siegal; David T Curiel; Akseli Hemminki
A cyclooxygenase-2 promoter-based conditionally replicating adenovirus with enhanced infectivity for treatment of ovarian adenocarcinoma.
Gene therapy 2004;11(6):552-9.
2003: Andrea L Volk; Angel A Rivera; Anna Kanerva; Gerd J Bauerschmitz; Igor Dmitriev; Dirk M Nettelbeck; David T Curiel
Enhanced adenovirus infection of melanoma cells by fiber-modification: incorporation of RGD peptide or Ad5/3 chimerism.
Cancer biology & therapy 2003;2(5):511-5.
2003: Anna Kanerva; Kurt R Zinn; Tandra R Chaudhuri; John T Lam; Kaori Suzuki; taco uil; Tanja Hakkarainen; Gerd J Bauerschmitz; Minghui Wang; Bin Liu; Zhihong Cao; Ronald D Alvarez; David T Curiel; Akseli Hemminki
Enhanced therapeutic efficacy for ovarian cancer with a serotype 3 receptor-targeted oncolytic adenovirus.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(3):449-58.
2003: John T Lam; Gerd J Bauerschmitz; Anna Kanerva; Shannon D Barker; J Michael Straughn; Minghui Wang; Mack N Barnes; Jerry L Blackwell; Gene P Siegal; Ronald D Alvarez; David T Curiel; Akseli Hemminki
Replication of an integrin targeted conditionally replicating adenovirus on primary ovarian cancer spheroids.
Cancer gene therapy 2003;10(5):377-87.
2003: Gernot Röder; Oliver Keil; Hans-Bernd Prisack; Gerd J Bauerschmitz; Bettina Hanstein; Caroline Nestle-Krämling; Akseli Hemminki; Hans Georg Bender; Dieter Niederacher; Peter Dall
Novel cGMP liposomal vectors mediate efficient gene transfer.
Cancer gene therapy 2003;10(4):312-7.
2003: Akseli Hemminki; Anna Kanerva; Eric J Kremer; Gerd J Bauerschmitz; Bruce F Smith; Bin Liu; Minghui Wang; Renee A Desmond; Anne Keriel; Brian G Barnett; Henry J Baker; Gene P Siegal; David T Curiel
A canine conditionally replicating adenovirus for evaluating oncolytic virotherapy in a syngeneic animal model.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(2):163-73.
2002: Gerd J Bauerschmitz; Shannon D Barker; Akseli Hemminki
Adenoviral gene therapy for cancer: from vectors to targeted and replication competent agents (review).
International journal of oncology 2002;21(6):1161-74.
2002: Anna Kanerva; Minghui Wang; Gerd J Bauerschmitz; John T Lam; Renee A Desmond; Snehal M Bhoola; Mack N Barnes; Ronald D Alvarez; Gene P Siegal; David T Curiel; Akseli Hemminki
Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(6):695-704.
2002: Gerd J Bauerschmitz; Dirk M Nettelbeck; Anna Kanerva; Andrew H Baker; Akseli Hemminki; Paul N Reynolds; David T Curiel
The flt-1 promoter for transcriptional targeting of teratocarcinoma.
Cancer research 2002;62(5):1271-4.
2002: Gerd J Bauerschmitz; John T Lam; Anna Kanerva; Kaori Suzuki; Dirk M Nettelbeck; Igor Dmitriev; Victor Krasnykh; Galina Mikheeva; Mack N Barnes; Ronald D Alvarez; Peter Dall; Ramon Alemany; David T Curiel; Akseli Hemminki
Treatment of ovarian cancer with a tropism modified oncolytic adenovirus.
Cancer research 2002;62(5):1266-70.