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James McCarthy

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TOP 3
David M Bender; Jingqi Bao; Anne H Dantzig; William D Diseroad; Kevin L Law; Nicholas A Magnus; Jeffrey A Peterson; Everett J Perkins; Yangwei J Pu; Susan M Reutzel-Edens; David M Remick; James J Starling; Gregory A Stephenson; Radhe K Vaid; Deyi Zhang; James R McCarthy
Synthesis, crystallization, and biological evaluation of an orally active prodrug of gemcitabine.
Isabel Rojo; José Alfredo Martín; Howard Broughton; David Timm; Jon Erickson; Hsiu-Chiung Yang; James R McCarthy
Macrocyclic peptidomimetic inhibitors of beta-secretase (BACE): first X-ray structure of a macrocyclic peptidomimetic-BACE complex.
Paloma Vidal; David Timm; Howard Broughton; Shu-Hui Chen; José Alfredo Martín; Alfonso Rivera-Sagredo; James R McCarthy; michael shapiro; Juan F Espinosa
Preorganization of the hydroxyethylene dipeptide isostere: the preferred conformation in solution resembles the conformation bound to BACE.

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All Publications

2009: David M Bender; Jingqi Bao; Anne H Dantzig; William D Diseroad; Kevin L Law; Nicholas A Magnus; Jeffrey A Peterson; Everett J Perkins; Yangwei J Pu; Susan M Reutzel-Edens; David M Remick; James J Starling; Gregory A Stephenson; Radhe K Vaid; Deyi Zhang; James R McCarthy
Synthesis, crystallization, and biological evaluation of an orally active prodrug of gemcitabine.
Journal of medicinal chemistry 2009;52(22):6958-61.
2006: Isabel Rojo; José Alfredo Martín; Howard Broughton; David Timm; Jon Erickson; Hsiu-Chiung Yang; James R McCarthy
Macrocyclic peptidomimetic inhibitors of beta-secretase (BACE): first X-ray structure of a macrocyclic peptidomimetic-BACE complex.
Bioorganic & medicinal chemistry letters 2006;16(1):191-5.
2005: Paloma Vidal; David Timm; Howard Broughton; Shu-Hui Chen; José Alfredo Martín; Alfonso Rivera-Sagredo; James R McCarthy; michael shapiro; Juan F Espinosa
Preorganization of the hydroxyethylene dipeptide isostere: the preferred conformation in solution resembles the conformation bound to BACE.
Journal of medicinal chemistry 2005;48(24):7623-7.
2004: minmin wang; Leonard L Winneroski; Robert J Ardecky; Robert E Babine; Dawn A Brooks; Garret J Etgen; Darrell R Hutchison; Raymond F Kauffman; Aaron Kunkel; Dale E Mais; Chahrzad Montrose-Rafizadeh; Kathleen M Ogilvie; Brian A Oldham; Mary K Peters; Christopher J Rito; Deepa Rungta; Allie E Tripp; Sarah B Wilson; Yanping Xu; Richard W Zink; James R McCarthy
Conversion of human-selective PPARalpha agonists to human/mouse dual agonists: a molecular modeling analysis.
Bioorganic & medicinal chemistry letters 2004;14(24):6113-6.
2004: Hsiu-Chiung Yang; Xiyun Chai; Marian Mosior; Wayne Kohn; Leonard N Boggs; Jon A Erickson; Don B McClure; Wu-Kuang Yeh; Lianshen Zhang; Patricia A Gonzalez-DeWhitt; John P Mayer; Jose Alfredo Martin; Jingdan Hu; Shu-Hui Chen; Ana Belen Bueno; Sheila P Little; James R McCarthy; Patrick May
Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1.
Journal of neurochemistry 2004;91(6):1249-59.
2004: Yanping Xu; Christopher J Rito; Garret J Etgen; Robert J Ardecky; James S Bean; William R Bensch; Jacob R Bosley; Carol L Broderick; Dawn A Brooks; Samuel J Dominianni; Patric J Hahn; Sha Liu; Dale E Mais; Chahrzad Montrose-Rafizadeh; Kathleen M Ogilvie; Brian A Oldham; Mary Peters; Deepa Rungta; Anthony J Shuker; Gregory A Stephenson; Allie E Tripp; Sarah B Wilson; Leonard L Winneroski; Richard W Zink; Raymond F Kauffman; James R McCarthy
Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists.
Journal of medicinal chemistry 2004;47(10):2422-5.
2003: Jingdan Hu; Cynthia L Cwi; David L Smiley; David Timm; Jon A Erickson; James E McGee; Hsiu-Chiung Yang; David Mendel; Patrick May; Mike Shapiro; James R McCarthy
Design and synthesis of statine-containing BACE inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(24):4335-9.
2003: Alexander G Godfrey; Dawn A Brooks; Lynne A Hay; Mary Peters; James R McCarthy; David Mitchell
Application of the Dakin-West reaction for the synthesis of oxazole-containing dual PPARalpha/gamma agonists.
The Journal of organic chemistry 2003;68(7):2623-32.
2002: Garret J Etgen; Brian A Oldham; William T Johnson; Carol L Broderick; Chahrzad R Montrose; Joseph T Brozinick; Elizabeth A Misener; James S Bean; William R Bensch; Dawn A Brooks; Anthony J Shuker; Christopher J Rito; James R McCarthy; Robert J Ardecky; John S Tyhonas; Sharon L Dana; James M Bilakovics; James R Paterniti; Kathleen M Ogilvie; Sha Liu; Raymond F Kauffman
A tailored therapy for the metabolic syndrome: the dual peroxisome proliferator-activated receptor-alpha/gamma agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while improving cardiovascular risk factors in preclinical models.
Diabetes 2002;51(4):1083-7.
2001: Dawn A Brooks; Garret J Etgen; Christopher J Rito; Anthony J Shuker; Samuel J Dominianni; Alan M Warshawsky; Robert J Ardecky; James R Paterniti; John S Tyhonas; Donald S Karanewsky; Raymond F Kauffman; Carol L Broderick; Brian A Oldham; Chahrzad Montrose-Rafizadeh; Leonard L Winneroski; Margaret M Faul; James R McCarthy
Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists.
Journal of medicinal chemistry 2001;44(13):2061-4.