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Carolyn McClain

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Nhat-Tu Le; Hakjoo Lee; Faqian Li; Carolyn McClain; Craig N Morrell; Iana M Serafimova; Mark A Sullivan; Yuichiro Takei; Jack Taunton; Xin Wang; Chang-Hoon Woo; Haodong Xu; Eugene Chang; Michael S Cohen; Keigi Fujiwara; Kyung-Sun Heo; Cheryl Hurley; Jun-Ichi Abe
A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis.
Nhat-Tu Le; Hakjoo Lee; Yan Lu; Carolyn McClain; Carlos A Molina; Craig N Morrell; Masayoshi Oikawa; Cam Patterson; Tetsuro Shishido; Yuichiro Takei; Jack Taunton; Cathy Tournier; Xin Wang; Chang-Hoon Woo; Chen Yan; Jay Yang; Eugene Chang; Keigi Fujiwara; Kyung-Sun Heo; Jun-ichi Abe
p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.
Kyung-Sun Heo; Hakjoo Lee; Patrizia Nigro; Tamlyn Thomas; Nhat-Tu Le; Eugene Chang; Carolyn McClain; Cynthia A Reinhart-King; Michael R King; Bradford C Berk; Keigi Fujiwara; Chang-Hoon Woo; Jun-ichi Abe
PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation.

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All Publications

2013: Nhat-Tu Le; Hakjoo Lee; Faqian Li; Carolyn McClain; Craig N Morrell; Iana M Serafimova; Mark A Sullivan; Yuichiro Takei; Jack Taunton; Xin Wang; Chang-Hoon Woo; Haodong Xu; Eugene Chang; Michael S Cohen; Keigi Fujiwara; Kyung-Sun Heo; Cheryl Hurley; Jun-Ichi Abe
A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis.
Circulation 2013;127(4):486-99.
2012: Nhat-Tu Le; Hakjoo Lee; Yan Lu; Carolyn McClain; Carlos A Molina; Craig N Morrell; Masayoshi Oikawa; Cam Patterson; Tetsuro Shishido; Yuichiro Takei; Jack Taunton; Cathy Tournier; Xin Wang; Chang-Hoon Woo; Chen Yan; Jay Yang; Eugene Chang; Keigi Fujiwara; Kyung-Sun Heo; Jun-ichi Abe
p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.
Circulation research 2012;110(4):536-50.
2011: Kyung-Sun Heo; Hakjoo Lee; Patrizia Nigro; Tamlyn Thomas; Nhat-Tu Le; Eugene Chang; Carolyn McClain; Cynthia A Reinhart-King; Michael R King; Bradford C Berk; Keigi Fujiwara; Chang-Hoon Woo; Jun-ichi Abe
PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation.
The Journal of cell biology 2011;193(5):867-84.
2010: Chang-Hoon Woo; Nhat-Tu Le; Tetsuro Shishido; Eugene Chang; Hakjoo Lee; Kyung-Sun Heo; Deanne M Mickelsen; Yan Lu; Carolyn McClain; Thomas Spangenberg; Chen Yan; Carlos A Molina; Jay Yang; Cam Patterson; Jun-ichi Abe
Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(12):4917-28.
2010: Patrizia Nigro; Jun-ichi Abe; Chang-Hoon Woo; Kimio Satoh; Carolyn McClain; Michael R O'Dell; Hakjoo Lee; Jae Hyang Lim; Jian-Dong Li; Kyung-Sun Heo; Keigi Fujiwara; Bradford C Berk
PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5.
Blood 2010;116(11):1971-9.
2008: Zhibo Lu; Jun-ichi Abe; Jack Taunton; Yan Lu; Tetsuro Shishido; Carolyn McClain; Chen Yan; Sheng Ping Xu; Thomas M Spangenberg; Haodong Xu
Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity.
Circulation research 2008;103(3):269-78.
2008: Tetsuro Shishido; Chang-Hoon Woo; Bo Ding; Carolyn McClain; Carlos A Molina; Chen Yan; Jay Yang; Jun-ichi Abe
Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: implications for diabetic ventricular dysfunction after myocardial infarction.
Circulation research 2008;102(11):1416-25.
2008: Chang-Hoon Woo; Tetsuro Shishido; Carolyn McClain; Jae Hyang Lim; Jian-Dong Li; Jay Yang; Chen Yan; Jun-ichi Abe
Extracellular signal-regulated kinase 5 SUMOylation antagonizes shear stress-induced antiinflammatory response and endothelial nitric oxide synthase expression in endothelial cells.
Circulation research 2008;102(5):538-45.
2007: Chen Yan; Bo Ding; Tetsuro Shishido; Chang-Hoon Woo; Seigo Itoh; Kye-Im Jeon; Weimin Liu; Haodong Xu; Carolyn McClain; Carlos A Molina; Burns C Blaxall; Jun-ichi Abe
Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop.
Circulation research 2007;100(4):510-9.
2006: Chang-Hoon Woo; Michael P Massett; Tetsuro Shishido; Seigo Itoh; Bo Ding; Carolyn McClain; Wenyi Che; Sreesatya Raju Vulapalli; Chen Yan; Jun-ichi Abe
ERK5 activation inhibits inflammatory responses via peroxisome proliferator-activated receptor delta (PPARdelta) stimulation.
The Journal of biological chemistry 2006;281(43):32164-74.
2000: Ami Mankodi; Eric L Logigian; L Callahan; Carolyn McClain; R White; Don Henderson; Matt Krym; Charles A Thornton
Myotonic dystrophy in transgenic mice expressing an expanded CUG repeat.
Science (New York, N.Y.) 2000;289(5485):1769-73.
1997: Charles A Thornton; J P Wymer; Zachary Simmons; Carolyn McClain; Richard T Moxley
Expansion of the myotonic dystrophy CTG repeat reduces expression of the flanking DMAHP gene.
Nature genetics 1997;16(4):407-9.