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Grant McClarty

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Lihua Song; Daniel E Sturdevant; Gail L Sturdevant; Kimmo Virtaneva; Heather Watkins; William M Whitmire; Bing Zhou; John H Carlson; Laszlo Kari; Grant McClarty; Stephen F Porcella; Harlan D Caldwell
Chlamydia trachomatis plasmid-encoded Pgp4 is a transcriptional regulator of virulence-associated genes.
Laszlo Kari; William M Whitmire; John H Carlson; Deborah D Crane; Nathalie Reveneau; David E Nelson; David C W Mabey; Robin L Bailey; Martin Holland; Grant McClarty; Harlan D Caldwell
Pathogenic diversity among Chlamydia trachomatis ocular strains in nonhuman primates is affected by subtle genomic variations.
Nina Voevodskaya; Marcus Galander; Martin Högbom; Pål Stenmark; Grant McClarty; Astrid Gräslund; Friedhelm Lendzian
Structure of the high-valent FeIIIFeIV state in ribonucleotide reductase (RNR) of Chlamydia trachomatis--combined EPR, 57Fe-, 1H-ENDOR and X-ray studies.

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All Publications

2013: Lihua Song; Daniel E Sturdevant; Gail L Sturdevant; Kimmo Virtaneva; Heather Watkins; William M Whitmire; Bing Zhou; John H Carlson; Laszlo Kari; Grant McClarty; Stephen F Porcella; Harlan D Caldwell
Chlamydia trachomatis plasmid-encoded Pgp4 is a transcriptional regulator of virulence-associated genes.
Infection and immunity 2013;81(3):636-44.
2008: Laszlo Kari; William M Whitmire; John H Carlson; Deborah D Crane; Nathalie Reveneau; David E Nelson; David C W Mabey; Robin L Bailey; Martin Holland; Grant McClarty; Harlan D Caldwell
Pathogenic diversity among Chlamydia trachomatis ocular strains in nonhuman primates is affected by subtle genomic variations.
The Journal of infectious diseases 2008;197(3):449-56.
2007: Nina Voevodskaya; Marcus Galander; Martin Högbom; Pål Stenmark; Grant McClarty; Astrid Gräslund; Friedhelm Lendzian
Structure of the high-valent FeIIIFeIV state in ribonucleotide reductase (RNR) of Chlamydia trachomatis--combined EPR, 57Fe-, 1H-ENDOR and X-ray studies.
Biochimica et biophysica acta 2007;1774(10):1254-63.
2007: David E Nelson; Lacey D Taylor; Jeffrey G Shannon; William M Whitmire; Deborah D Crane; Grant McClarty; Hua Su; Laszlo Kari; Harlan D Caldwell
Phenotypic rescue of Chlamydia trachomatis growth in IFN-gamma treated mouse cells by irradiated Chlamydia muridarum.
Cellular microbiology 2007;9(9):2289-98.
2007: Grant McClarty; Harlan D Caldwell; David E Nelson
Chlamydial interferon gamma immune evasion influences infection tropism.
Current opinion in microbiology 2007;10(1):47-51.
2006: John H Carlson; Heidi Wood; Christine Roshick; Harlan D Caldwell; Grant McClarty
In vivo and in vitro studies of Chlamydia trachomatis TrpR:DNA interactions.
Molecular microbiology 2006;59(6):1678-91.
2006: Christine Roshick; Heidi Wood; Harlan D Caldwell; Grant McClarty
Comparison of gamma interferon-mediated antichlamydial defense mechanisms in human and mouse cells.
Infection and immunity 2006;74(1):225-38.
2005: John H Carlson; Stephen F Porcella; Grant McClarty; Harlan D Caldwell
Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains.
Infection and immunity 2005;73(10):6407-18.
2005: David E Nelson; Virok Dezso; Heidi Wood; Christine Roshick; Raymond M Johnson; William M Whitmire; Deborah D Crane; Olivia Steele-Mortimer; Laszlo Kari; Grant McClarty; Harlan D Caldwell
Chlamydial IFN-gamma immune evasion is linked to host infection tropism.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(30):10658-63.
2005: Jonathon Griffin; Christine Roshick; Emma R Iliffe-Lee; Grant McClarty
Catalytic mechanism of Chlamydia trachomatis flavin-dependent thymidylate synthase.
The Journal of biological chemistry 2005;280(7):5456-67.
2004: John H Carlson; Scott Hughes; Daniel Hogan; Gordon Cieplak; Daniel E Sturdevant; Grant McClarty; Harlan D Caldwell; Robert J Belland
Polymorphisms in the Chlamydia trachomatis cytotoxin locus associated with ocular and genital isolates.
Infection and immunity 2004;72(12):7063-72.
2004: Martin Högbom; Pål Stenmark; Nina Voevodskaya; Grant McClarty; Astrid Gräslund; Pär Nordlund
The radical site in chlamydial ribonucleotide reductase defines a new R2 subclass.
Science (New York, N.Y.) 2004;305(5681):245-8.
2004: Heidi Wood; Christine Roshick; Grant McClarty
Tryptophan recycling is responsible for the interferon-gamma resistance of Chlamydia psittaci GPIC in indoleamine dioxygenase-expressing host cells.
Molecular microbiology 2004;52(3):903-16.
2004: Heng Su; Grant McClarty; Feng Dong; Grant M Hatch; Zhixing K Pan; Guangming Zhong
Activation of Raf/MEK/ERK/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids.
The Journal of biological chemistry 2004;279(10):9409-16.
2004: Grant M Hatch; Grant McClarty
C. trachomatis-infection accelerates metabolism of phosphatidylcholine derived from low density lipoprotein but does not affect phosphatidylcholine secretion from hepatocytes.
BMC microbiology 2004;4():8.
2004: Pål Stenmark; Martin Högbom; Christine Roshick; Grant McClarty; Pär Nordlund
Crystals of the ribonucleotide reductase R2 protein from Chlamydia trachomatis obtained by heavy-atom co-crystallization.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 2):376-8.
2004: Whitney Greene; Yangming Xiao; Yanqing Huang; Grant McClarty; Guangming Zhong
Chlamydia-infected cells continue to undergo mitosis and resist induction of apoptosis.
Infection and immunity 2004;72(1):451-60.
2003: Heidi Wood; Christine Fehlner-Gardner; Jody Berry; Elizabeth Fischer; Bonnie Graham; Ted Hackstadt; Christine Roshick; Grant McClarty
Regulation of tryptophan synthase gene expression in Chlamydia trachomatis.
Molecular microbiology 2003;49(5):1347-59.
2003: Harlan D Caldwell; Heidi Wood; Deborah D Crane; Robin Bailey; Robert B Jones; David Mabey; Ian Maclean; Zeena Mohammed; Rosanna W Peeling; Christine Roshick; Julius Schachter; Anthony W Solomon; Walter E Stamm; Robert J Suchland; Lacey Taylor; Sheila K West; Thomas C Quinn; Robert J Belland; Grant McClarty
Polymorphisms in Chlamydia trachomatis tryptophan synthase genes differentiate between genital and ocular isolates.
The Journal of clinical investigation 2003;111(11):1757-69.
2003: Timothy D Read; Garry S A Myers; Robert brunham; William C Nelson; Ian Paulsen; John F Heidelberg; Erik Holtzapple; Hoda Khouri; N B Federova; H A Carty; Lowell Umayam; Daniel H Haft; J Peterson; Maureen J Beanan; Owen R White; Steven L Salzberg; Ruching Hsia; Grant McClarty; Roger Rank; Patrik M Bavoil; Claire M Fraser-Liggett
Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae.
Nucleic acids research 2003;31(8):2134-47.
2002: Christine Fehlner-Gardiner; Christine Roshick; John H Carlson; Scott Hughes; Robert J Belland; Harlan D Caldwell; Grant McClarty
Molecular basis defining human Chlamydia trachomatis tissue tropism. A possible role for tryptophan synthase.
The Journal of biological chemistry 2002;277(30):26893-903.
2002: Emma R Iliffe-Lee; Grant McClarty
Pyruvate kinase from Chlamydia trachomatis is activated by fructose-2,6-bisphosphate.
Molecular microbiology 2002;44(3):819-28.
2001: Robert J Belland; Marci scidmore; Deborah D Crane; Daniel M Hogan; William M Whitmire; Grant McClarty; Harlan D Caldwell
Chlamydia trachomatis cytotoxicity associated with complete and partial cytotoxin genes.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13984-9.
2000: Christine Roshick; Emma R Iliffe-Lee; Grant McClarty
Cloning and characterization of ribonucleotide reductase from Chlamydia trachomatis.
The Journal of biological chemistry 2000;275(48):38111-9.
2000: Emma R Iliffe-Lee; Grant McClarty
Regulation of carbon metabolism in Chlamydia trachomatis.
Molecular microbiology 2000;38(1):20-30.
2000: Timothy D Read; Robert brunham; C Shen; Steven R Gill; John F Heidelberg; Owen R White; EK Hickey; J Peterson; Teresa Utterback; K Berry; S Bass; K Linher; Janice Weidman; Hoda Khouri; B Craven; C Bowman; Robert J Dodson; Michelle G Giglio; W Nelson; Robert T Deboy; James F Kolonay; Grant McClarty; Steven L Salzberg; Jonathan Eisen; Claire M Fraser-Liggett
Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39.
Nucleic acids research 2000;28(6):1397-406.
1999: Emma R Iliffe-Lee; Grant McClarty
Glucose metabolism in Chlamydia trachomatis: the 'energy parasite' hypothesis revisited.
Molecular microbiology 1999;33(1):177-87.
1998: Grant M Hatch; Grant McClarty
Phospholipid composition of purified Chlamydia trachomatis mimics that of the eucaryotic host cell.
Infection and immunity 1998;66(8):3727-35.
1998: T Fan; H Lu; H Hu; L Shi; Grant McClarty; Dwight M Nance; Arnold H Greenberg; Guangming Zhong
Inhibition of apoptosis in chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation.
The Journal of experimental medicine 1998;187(4):487-96.
1998: Grant M Hatch; Grant McClarty
Cardiolipin remodeling in eukaryotic cells infected with Chlamydia trachomatis is linked to elevated mitochondrial metabolism.
Biochemical and biophysical research communications 1998;243(2):356-60.
1997: J L Wylie; Grant M Hatch; Grant McClarty
Host cell phospholipids are trafficked to and then modified by Chlamydia trachomatis.
Journal of bacteriology 1997;179(23):7233-42.
1997: D Zhang; Xi Yang; Jody Berry; Caixia Shen; Grant McClarty; Robert brunham
DNA vaccination with the major outer-membrane protein gene induces acquired immunity to Chlamydia trachomatis (mouse pneumonitis) infection.
The Journal of infectious diseases 1997;176(4):1035-40.
1997: AJ Rusnak; Rabban Mangat; F Xu; Grant McClarty; Grant M Hatch
Cardiolipin remodeling in a Chinese hamster lung fibroblast cell line deficient in oxidative energy production.
Journal of bioenergetics and biomembranes 1997;29(3):291-8.
1997: J L Wylie; E R Iliffe; L L Wang; Grant McClarty
Identification, characterization, and developmental regulation of Chlamydia trachomatis 3-deoxy-D-manno-octulosonate (KDO)-8-phosphate synthetase and CMP-KDO synthetase.
Infection and immunity 1997;65(4):1527-30.
1996: J L Wylie; Jody Berry; Grant McClarty
Chlamydia trachomatis CTP synthetase: molecular characterization and developmental regulation of expression.
Molecular microbiology 1996;22(4):631-42.
1996: Grant M Hatch; Grant McClarty
Regulation of cardiolipin biosynthesis in H9c2 cardiac myoblasts by cytidine 5'-triphosphate.
The Journal of biological chemistry 1996;271(42):25810-6.
1996: J L Wylie; L L Wang; G Tipples; Grant McClarty
A single point mutation in CTP synthetase of Chlamydia trachomatis confers resistance to cyclopentenyl cytosine.
The Journal of biological chemistry 1996;271(26):15393-400.
1995: G Tipples; Grant McClarty
Cloning and expression of the Chlamydia trachomatis gene for CTP synthetase.
The Journal of biological chemistry 1995;270(14):7908-14.
1995: D J Zhang; H Fan; Grant McClarty; Robert brunham
Identification of the Chlamydia trachomatis RecA-encoding gene.
Infection and immunity 1995;63(2):676-80.
1994: L L Wang; E Henson; Grant McClarty
Characterization of trimethoprim- and sulphisoxazole-resistant Chlamydia trachomatis.
Molecular microbiology 1994;14(2):271-81.
1994: Grant McClarty
Chlamydiae and the biochemistry of intracellular parasitism.
Trends in microbiology 1994;2(5):157-64.
1993: Grant McClarty; H Fan
Purine metabolism by intracellular Chlamydia psittaci.
Journal of bacteriology 1993;175(15):4662-9.
1993: Grant McClarty; B Qin
Pyrimidine metabolism by intracellular Chlamydia psittaci.
Journal of bacteriology 1993;175(15):4652-61.
1993: G Tipples; Grant McClarty
The obligate intracellular bacterium Chlamydia trachomatis is auxotrophic for three of the four ribonucleoside triphosphates.
Molecular microbiology 1993;8(6):1105-14.
1993: Grant McClarty; H Fan; A A Andersen
Diversity in nucleotide acquisition by antigenically similar Chlamydia psittaci of avian origin.
FEMS microbiology letters 1993;108(3):325-31.
1992: H Fan; Robert brunham; Grant McClarty
Acquisition and synthesis of folates by obligate intracellular bacteria of the genus Chlamydia.
The Journal of clinical investigation 1992;90(5):1803-11.
1992: B Qin; Grant McClarty
Effect of 6-thioguanine on Chlamydia trachomatis growth in wild-type and hypoxanthine-guanine phosphoribosyltransferase-deficient cells.
Journal of bacteriology 1992;174(9):2865-73.
1991: H Z Fan; Grant McClarty; Robert brunham
Biochemical evidence for the existence of thymidylate synthase in the obligate intracellular parasite Chlamydia trachomatis.
Journal of bacteriology 1991;173(21):6670-7.
1991: Grant McClarty; G Tipples
In situ studies on incorporation of nucleic acid precursors into Chlamydia trachomatis DNA.
Journal of bacteriology 1991;173(16):4922-31.
1991: G Tipples; Grant McClarty
Isolation and initial characterization of a series of Chlamydia trachomatis isolates selected for hydroxyurea resistance by a stepwise procedure.
Journal of bacteriology 1991;173(16):4932-40.
1990: JA Wright; A K Chan; B K Choy; R A Hurta; Grant McClarty; A Y Tagger
Regulation and drug resistance mechanisms of mammalian ribonucleotide reductase, and the significance to DNA synthesis.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1990;68(12):1364-71.
1990: Grant McClarty; A K Chan; B K Choy; JA Wright
Increased ferritin gene expression is associated with increased ribonucleotide reductase gene expression and the establishment of hydroxyurea resistance in mammalian cells.
The Journal of biological chemistry 1990;265(13):7539-47.
1989: B K Choy; Grant McClarty; JA Wright
Transient elevation of ribonucleotide reductase activity, M2 mRNA and M2 protein in BALB/c 3T3 fibroblasts in the presence of 12-O-tetradecanoylphorbol-13-acetate.
Biochemical and biophysical research communications 1989;162(3):1417-24.
1988: Grant McClarty; A K Chan; B K Choy; L Thelander; JA Wright
Molecular mechanisms responsible for the drug-induced posttranscriptional modulation of ribonucleotide reductase levels in a hydroxyurea-resistant mouse L cell line.
Biochemistry 1988;27(19):7524-31.
1988: Grant McClarty; Patricia N Tonin; P R Srinivasan; JA Wright
Relationships between reversion of hydroxyurea resistance in hamster cells and the co-amplification of ribonucleotide reductase M2 component, ornithine decarboxylase and P5-8 genes.
Biochemical and biophysical research communications 1988;154(3):975-81.
1988: B K Choy; Grant McClarty; A K Chan; L Thelander; JA Wright
Molecular mechanisms of drug resistance involving ribonucleotide reductase: hydroxyurea resistance in a series of clonally related mouse cell lines selected in the presence of increasing drug concentrations.
Cancer research 1988;48(8):2029-35.
1988: Asher Begleiter; Marsha K Leith; Grant McClarty; S Beenken; Gerald J Goldenberg; JA Wright
Characterization of L5178Y murine lymphoblasts resistant to quinone antitumor agents.
Cancer research 1988;48(7):1727-35.
1987: Grant McClarty; A K Chan; Y Engstrom; JA Wright; L Thelander
Elevated expression of M1 and M2 components and drug-induced posttranscriptional modulation of ribonucleotide reductase in a hydroxyurea-resistant mouse cell line.
Biochemistry 1987;26(24):8004-11.
1987: Grant McClarty; A K Chan; B K Choy; JA Wright
Reversion of hydroxyurea resistance, decline in ribonucleotide reductase activity, and loss of M2 gene amplification.
Biochemical and biophysical research communications 1987;145(3):1276-82.
1987: JA Wright; T G Alam; Grant McClarty; A Y Tagger; L Thelander
Altered expression of ribonucleotide reductase and role of M2 gene amplification in hydroxyurea-resistant hamster, mouse, rat, and human cell lines.
Somatic cell and molecular genetics 1987;13(2):155-65.
1986: Grant McClarty; A K Chan; JA Wright
Hydroxyurea-induced conversion of mammalian ribonucleotide reductase to a form hypersensitive to bleomycin.
Cancer research 1986;46(9):4516-21.
1986: Grant McClarty; A K Chan; JA Wright
Characterization of a mouse cell line selected for hydroxyurea resistance by a stepwise procedure: drug-dependent overproduction of ribonucleotide reductase activity.
Somatic cell and molecular genetics 1986;12(2):121-31.
1985: Grant McClarty; A K Chan; D C Creasey; JA Wright
Ribonucleotide reductase: an intracellular target for the male antifertility agent, gossypol.
Biochemical and biophysical research communications 1985;133(1):300-5.