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Christopher Baum

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

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Gene Transfer Techniques

Genes & Molecular Sequences

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Mutagenesis, Insertional

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TOP 3
Martijn Brugman; Olga S Kustikova; Ute Modlich; Michael Rothe; Axel Schambach; Sebastian Suerbaum; Julia D Suerth; Christopher Baum
Evaluating a ligation-mediated PCR and pyrosequencing method for the detection of clonal contribution in polyclonal retrovirally transduced samples.
Beate Vajen; Alejandro Vaquero; Susanne Wolf; Christopher Baum; Guntram Büsche; Winfried Hofmann; Hans Kreipe; Ute Modlich; Irene Santos-Barriopedro; Andrea Schienke; Brigitte Schlegelberger; Britta Skawran; Cornelia Rudolph
Histone methyltransferase Suv39h1 deficiency prevents Myc-induced chromosomal instability in murine myeloid leukemias.
Olga S Kustikova; Zhixiong Li; T Neumann; Ingo Roeder; Axel Schambach; Brigitte Schlegelberger; A Schwarzer; M Stahlhut; Doris Steinemann; M Yang; Martijn Brugman; S Gerdes; T C Ha; N Heinz; Christopher Baum
Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells.

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All Publications

2013: Martijn Brugman; Olga S Kustikova; Ute Modlich; Michael Rothe; Axel Schambach; Sebastian Suerbaum; Julia D Suerth; Christopher Baum
Evaluating a ligation-mediated PCR and pyrosequencing method for the detection of clonal contribution in polyclonal retrovirally transduced samples.
Human gene therapy methods 2013;24(2):68-79.
2013: Beate Vajen; Alejandro Vaquero; Susanne Wolf; Christopher Baum; Guntram Büsche; Winfried Hofmann; Hans Kreipe; Ute Modlich; Irene Santos-Barriopedro; Andrea Schienke; Brigitte Schlegelberger; Britta Skawran; Cornelia Rudolph
Histone methyltransferase Suv39h1 deficiency prevents Myc-induced chromosomal instability in murine myeloid leukemias.
Genes, chromosomes & cancer 2013;52(4):423-30.
2013: Olga S Kustikova; Zhixiong Li; T Neumann; Ingo Roeder; Axel Schambach; Brigitte Schlegelberger; A Schwarzer; M Stahlhut; Doris Steinemann; M Yang; Martijn Brugman; S Gerdes; T C Ha; N Heinz; Christopher Baum
Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells.
Leukemia 2013;27(5):1127-38.
2013: Kerstin B Kaufmann; Hana Kunkel; Uta Mueller-Kuller; Shweta Pahujani; Axel Schambach; Joachim Schwäble; Julia D Suerth; Christopher Baum; Christian Brendel; Linping Chen-Wichmann; Manuel Grez
Alpharetroviral vector-mediated gene therapy for X-CGD: functional correction and lack of aberrant splicing.
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(3):648-61.
2013: N Lachmann; Ute Modlich; Christopher Baum; S Brennig; J Dahlmann; Ina Gruh; N Pfaff; R Phaltane; Axel Schambach; H Schermeier; T Moritz
Efficient in vivo regulation of cytidine deaminase expression in the haematopoietic system using a doxycycline-inducible lentiviral vector system.
Gene therapy 2013;20(3):298-307.
2013: Axel Schambach; Daniela Zychlinski; Birgitta Ehrnstroem; Christopher Baum
Biosafety features of lentiviral vectors.
Human gene therapy 2013;24(2):132-42.
2013: Melanie Galla; Axel Schambach; Christopher Baum
Retrovirus-based mRNA transfer for transient cell manipulation.
Methods in molecular biology (Clifton, N.J.) 2013;969():139-61.
2012: Axel Schambach; Christopher Baum
Vectorizing mRNA and proteins.
Current gene therapy 2012;12(5):345-6.
2012: Christopher Baum
Conditional negative selection of gene-modified hematopoietic stem cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(10):1841-2.
2012: Julia D Suerth; Axel Schambach; Christopher Baum
Genetic modification of lymphocytes by retrovirus-based vectors.
Current opinion in immunology 2012;24(5):598-608.
2012: Tobias Maetzig; Christopher Baum; Axel Schambach
Retroviral protein transfer: falling apart to make an impact.
Current gene therapy 2012;12(5):389-409.
2012: Hartmut Geiger; John H Griffin; Christopher Baum; Jose A Cancelas; Jose Á Fernández; Louis M Fink; Qiang Fu; Irene Hernandez; Edward J Kerschen; Olga Kustikova; Hai Po H Liang; Kalpana J Nattamai; Snehalata A Pawar; Karl-Uwe Petersen; MA Ryan; Axel Schambach; Junru Wang; Hartmut Weiler; Daohong Zhou; Martin Hauer-Jensen
Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity.
Nature medicine 2012;18(7):1123-9.
2012: Dirk Heckl; Sabine Knoess; Johanna Krause; Zhixiong Li; Cornelia Rudolph; Brigitte Schlegelberger; Adrian Schwarzer; Britta Skawran; Doris Steinemann; Christopher Baum; Reinhard Haemmerle; Ute Modlich
Lentiviral vector induced insertional haploinsufficiency of Ebf1 causes murine leukemia.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(6):1187-95.
2012: Julia D Suerth; Manfred Schmidt; Jens-Uwe Appelt; Christopher Baum; Martijn Brugman; Manuel Grez; Niels Heinz; Kerstin B Kaufmann; Tobias Maetzig; Ute Modlich; Axel Schambach
Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(5):1022-32.
2012: M Rothe; U Rüdrich; Axel Schambach; M Ott; I Rittelmeyer; Christopher Baum; M Bock; S Glage; M Iken; Michael P Manns; Ute Modlich
Epidermal growth factor improves lentivirus vector gene transfer into primary mouse hepatocytes.
Gene therapy 2012;19(4):425-34.
2012: Nils Pfaff; Axel Schambach; Malte Sgodda; Heiner Niemann; Marcos J Arauzo-Bravo; Christopher Baum; Tobias Cantz; Silke Glage; Boris Greber; Saskia Kohlscheen; Wilfried Kues; Nico Lachmann; Thomas Moritz
Efficient hematopoietic redifferentiation of induced pluripotent stem cells derived from primitive murine bone marrow cells.
Stem cells and development 2012;21(5):689-701.
2012: Christine Voelkel; Philip N Dannhauser; Melanie Galla; Tobias Maetzig; Axel Schambach; Beate Sodeik; Christopher Baum
Pseudotype-independent nonspecific uptake of gammaretroviral and lentiviral particles in human cells.
Human gene therapy 2012;23(3):274-86.
2012: J C M van der Loo; David A Williams; Christopher Baum; E Grassman; T Higashimoto; D L Nordling; Lilith Reeves; Axel Schambach; W P Swaney; A Terwilliger; A J Thrasher; P Malik
Scale-up and manufacturing of clinical-grade self-inactivating γ-retroviral vectors by transient transfection.
Gene therapy 2012;19(3):246-54.
2011: Annette Deichmann; Cynthia E Dunbar; Alain Fischer; Richard Gabriel; H Bobby Gaspar; Hanno Glimm; Manuel Grez; Salima Hacein-Bey-Abina; Dieter Hoelzer; Steven J Howe; Fulvio Mavilio; Marion G Ott; Anna Paruzynski; Manfred Schmidt; Kerstin Schwarzwaelder; Reinhard Seger; Adrian J Thrasher; Monique M A Verstegen; Christof von Kalle; Ulrich Abel; Alessandro Aiuti; Anne Arens; Cynthia C Bartholomae; Christopher Baum; Martijn Brugman; Barbara Cassani; Claudia Cattoglio; Marina Cavazzana-Calvo; Gerard Wagemaker
Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(11):2031-9.
2011: Inés Avedillo Díez; Christopher Baum; Kaan Boztug; Emanuele G Coci; Ricardo A Dewey; Melanie Galla; Elmar Jaeckel; Christoph Klein; Tobias Maetzig; Ute Modlich; Nonsikelelo Mpofu; Adrian Schwarzer; Daniela Zychlinski; Axel Schambach
Development of novel efficient SIN vectors with improved safety features for Wiskott-Aldrich syndrome stem cell based gene therapy.
Molecular pharmaceutics 2011;8(5):1525-37.
2011: Christopher Baum; Gudrun Göhring; Ute Modlich; Brigitte Schlegelberger
Concise review: managing genotoxicity in the therapeutic modification of stem cells.
Stem cells (Dayton, Ohio) 2011;29(10):1479-84.
2011: Juliane W Schott; Christopher Baum; Melanie Galla; Tamaryin Godinho; Axel Schambach
Viral and non-viral approaches for transient delivery of mRNA and proteins.
Current gene therapy 2011;11(5):382-98.
2011: Marshall W Huston; Yuedan Li; Fulvio Mavilio; Ali Nowrouzi; Axel Schambach; Manfred Schmidt; Adrian J Thrasher; Niek P van Til; Monique M A Verstegen; Trudi P Visser; Christof von Kalle; Shazia Arshad; Christopher Baum; Mike P Blundell; Martijn Brugman; Claudia Cattoglio; Fang Zhang; Gerard Wagemaker
Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(10):1867-77.
2011: Karin Pike-Overzet; M Rodijk; A Schambach; Adrian J Thrasher; J J M van Dongen; F Zhang; M R M Baert; Christopher Baum; R G M Bredius; M Cavazzana-Calvo; G J A Driessen; Salima Hacein-Bey-Abina; Rob Hoeben; C Lagresle-Peyrou; Arjan C Lankester; Yuk Yin Ng; Frank Staal
Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer.
Leukemia 2011;25(9):1471-83.
2011: Melanie Galla; Gudrun Göhring; Niels Heinz; Zoltán Ivics; Zsuzsanna Izsvák; Johannes Kuehle; Kathrin Lange; Tobias Maetzig; Axel Schambach; Daniela Zychlinski; Martijn Brugman; Christine S Falk; Christopher Baum
Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery.
Nucleic acids research 2011;39(16):7147-60.
2011: Tobias Maetzig; Christopher Baum; Melanie Galla; Axel Schambach
Gammaretroviral vectors: biology, technology and application.
Viruses 2011;3(6):677-713.
2011: Christopher Baum
[Prevention of insertional mutagenesis. Inevitable or manageable?].
Pharmazie in unserer Zeit 2011;40(3):248-52.
2011: Dirk Heckl; Daniel C Wicke; Martijn Brugman; Johann Meyer; Axel Schambach; Guntram Büsche; Matthias Ballmaier; Christopher Baum; Ute Modlich
Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia.
Blood 2011;117(14):3737-47.
2011: Eva Warlich; Johannes Kuehle; Tobias Cantz; Martijn Brugman; Tobias Maetzig; Melanie Galla; Adam A Filipczyk; Stephan Halle; Hannes Klump; Hans R Schöler; Christopher Baum; Timm Schroeder; Axel Schambach
Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(4):782-9.
2011: Tobias Maetzig; Martijn Brugman; Stefan Bartels; Niels Heinz; Olga S Kustikova; Ute Modlich; Zhixiong Li; Melanie Galla; Bernhard Schiedlmeier; Axel Schambach; Christopher Baum
Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.
Blood 2011;117(11):3053-64.
2011: Mathias Rhein; Adrian Schwarzer; Min Yang; Volkhard Kaever; Martijn Brugman; Johann Meyer; Arnold Ganser; Christopher Baum; Zhixiong Li
Leukemias induced by altered TRK-signaling are sensitive to mTOR inhibitors in preclinical models.
Annals of hematology 2011;90(3):283-92.
2011: Christopher Baum
Parachuting in the epigenome: the biology of gene vector insertion profiles in the context of clinical trials.
EMBO molecular medicine 2011;3(2):75-7.
2011: Niels Heinz; Axel Schambach; Melanie Galla; Tobias Maetzig; Christopher Baum; Rainer Loew; Bernhard Schiedlmeier
Retroviral and transposon-based tet-regulated all-in-one vectors with reduced background expression and improved dynamic range.
Human gene therapy 2011;22(2):166-76.
2010: Soeren Turan; Johannes Kuehle; Axel Schambach; Christopher Baum; Juergen Bode
Multiplexing RMCE: versatile extensions of the Flp-recombinase-mediated cassette-exchange technology.
Journal of molecular biology 2010;402(1):52-69.
2010: Olga S Kustikova; Martijn Brugman; Christopher Baum
The genomic risk of somatic gene therapy.
Seminars in cancer biology 2010;20(4):269-78.
2010: Axel Schambach; Tobias Cantz; Christopher Baum; Toni Cathomen
Generation and genetic modification of induced pluripotent stem cells.
Expert opinion on biological therapy 2010;10(7):1089-103.
2010: Julia D Suerth; Tobias Maetzig; Melanie Galla; Christopher Baum; Axel Schambach
Self-inactivating alpharetroviral vectors with a split-packaging design.
Journal of virology 2010;84(13):6626-35.
2010: Christine Voelkel; Melanie Galla; Tobias Maetzig; Eva Warlich; Johannes Kuehle; Daniela Zychlinski; Juergen Bode; Tobias Cantz; Axel Schambach; Christopher Baum
Protein transduction from retroviral Gag precursors.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(17):7805-10.
2010: Christopher Baum
The promise of polyclonality.
Human gene therapy 2010;21(4):365-7.
2010: T Maetzig; Melanie Galla; Martijn Brugman; R Loew; Christopher Baum; Axel Schambach
Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors.
Gene therapy 2010;17(3):400-11.
2010: Daniel C Wicke; Johann Meyer; Guntram Buesche; Dirk Heckl; Hans Kreipe; Zhixiong Li; Karl H Welte; Matthias Ballmaier; Christopher Baum; Ute Modlich
Gene therapy of MPL deficiency: challenging balance between leukemia and pancytopenia.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(2):343-52.
2009: Daniela Zychlinski; Steffen Erkelenz; Vanessa Melhorn; Christopher Baum; Heiner Schaal; Jens Bohne
Limited complementarity between U1 snRNA and a retroviral 5' splice site permits its attenuation via RNA secondary structure.
Nucleic acids research 2009;37(22):7429-40.
2009: Paritha I Arumugam; Tomoyasu Higashimoto; Fabrizia Urbinati; Ute Modlich; Shawna Nestheide; Ping Xia; Catherine Fox; Andrea Corsinotti; Christopher Baum; Punam Malik
Genotoxic potential of lineage-specific lentivirus vectors carrying the beta-globin locus control region.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(11):1929-37.
2009: Ute Modlich; Susana Navarro; Daniela Zychlinski; Tobias Maetzig; Sabine Knoess; Martijn Brugman; Axel Schambach; Sabine Charrier; Anne Galy; Adrian J Thrasher; Juan Bueren; Christopher Baum
Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(11):1919-28.
2009: Olga S Kustikova; Bernhard Schiedlmeier; Martijn Brugman; Maike Stahlhut; Stefan Bartels; Zhixiong Li; Christopher Baum
Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(9):1537-47.
2009: Christopher Baum; R Förster; Reinhold E Schmidt
[Advancement of the medical doctorate].
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 2009;52(8):856-61.
2009: Ute Modlich; Christopher Baum
Preventing and exploiting the oncogenic potential of integrating gene vectors.
The Journal of clinical investigation 2009;119(4):755-8.
2009: Felix G Hermann; Holger Martinius; Marc Egelhofer; Tsanan Giroglou; Torsten Tonn; Stefanie D Roth; Roland Zahn; Patricia Schult-Dietrich; Alexander Alexandrov; Ursula Dietrich; Christopher Baum; Dorothee von Laer
Protein scaffold and expression level determine antiviral activity of membrane-anchored antiviral peptides.
Human gene therapy 2009;20(4):325-36.
2008: Michael D Milsom; Moran Jerabek-Willemsen; Chad E Harris; Axel Schambach; Emily Broun; Jeff Bailey; Michael Jansen; David Schleimer; Kalpana Nattamai; Jamie Wilhelm; Amanda Watson; Hartmut Geiger; Geoffrey P Margison; Thomas Moritz; Christopher Baum; Jürgen Thomale; David A Williams
Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells.
Cancer research 2008;68(15):6171-80.
2008: Ute Modlich; Axel Schambach; Martijn Brugman; D C Wicke; S Knoess; Zhixiong Li; T Maetzig; Cornelia Rudolph; Brigitte Schlegelberger; Christopher Baum
Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16.
Leukemia 2008;22(8):1519-28.
2008: Daniela Zychlinski; Axel Schambach; Ute Modlich; Tobias Maetzig; Johann Meyer; Elke Grassman; Anjali Mishra; Christopher Baum
Physiological promoters reduce the genotoxic risk of integrating gene vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(4):718-25.
2008: Melanie Galla; Axel Schambach; Greg J Towers; Christopher Baum
Cellular restriction of retrovirus particle-mediated mRNA transfer.
Journal of virology 2008;82(6):3069-77.
2008: Susannah I Thornhill; Axel Schambach; Steven J Howe; Meera Ulaganathan; Elke Grassman; David Williams; Bernhard Schiedlmeier; Neil J Sebire; H Bobby Gaspar; Christine Kinnon; Christopher Baum; Adrian J Thrasher
Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(3):590-8.
2008: Olga S Kustikova; Christopher Baum; Boris Fehse
Retroviral integration site analysis in hematopoietic stem cells.
Methods in molecular biology (Clifton, N.J.) 2008;430():255-67.
2007: Christopher Baum; Axel Schambach; Ute Modlich; A Thrasher
[Gene therapy of SCID-X1].
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 2007;50(12):1507-17.
2007: Bernhard Schiedlmeier; Ana Cristina Santos; Ana Ribeiro; Natalia Moncaut; Dietrich Lesinski; Herbert Auer; Karl Kornacker; Wolfram Ostertag; Christopher Baum; Moises Mallo; Hannes Klump
HOXB4's road map to stem cell expansion.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):16952-7.
2007: Johann Meyer; M Rhein; Bernhard Schiedlmeier; Olga S Kustikova; Cornelia Rudolph; Kenji Kamino; T Neumann; M Yang; Anke Wahlers; Boris Fehse; Gary W Reuther; Brigitte Schlegelberger; Arnold Ganser; Christopher Baum; Zhixiong Li
Remarkable leukemogenic potency and quality of a constitutively active neurotrophin receptor, deltaTrkA.
Leukemia 2007;21(10):2171-80.
2007: Michael Heuser; Bob Argiropoulos; Florian Kuchenbauer; Eric Yung; Jessica Piper; Stephen Fung; Richard F Schlenk; Konstanze Dohner; Tanja Hinrichsen; Cornelia Rudolph; Axel Schambach; Christopher Baum; Brigitte Schlegelberger; Hartmut Dohner; Arnold Ganser; R Keith Humphries
MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML.
Blood 2007;110(5):1639-47.
2007: Axel Schambach; Christopher Baum
Vector design for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells.
DNA repair 2007;6(8):1187-96.
2007: Christopher Baum
Insertional mutagenesis in gene therapy and stem cell biology.
Current opinion in hematology 2007;14(4):337-42.
2007: Axel Schambach; Melanie Galla; Tobias Maetzig; Rainer Loew; Christopher Baum
Improving transcriptional termination of self-inactivating gamma-retroviral and lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(6):1167-73.
2007: Zhixiong Li; Olga S Kustikova; Kenji Kamino; Thomas Neumann; Mathias Rhein; Elke Grassman; Boris Fehse; Christopher Baum
Insertional mutagenesis by replication-deficient retroviral vectors encoding the large T oncogene.
Annals of the New York Academy of Sciences 2007;1106():95-113.
2007: Christopher Baum
I could die for you: new prospects for suicide in gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(5):848-9.
2007: Jan van Lunzen; Tobias Glaunsinger; Ingrid Stahmer; Volker von Baehr; Christopher Baum; Andrea Schilz; Klaus Kuehlcke; Sonja Naundorf; Holger Martinius; Felix Hermann; Tsanan Giroglou; Sebastian Newrzela; Ingrid Müller; Francis Brauer; Gunda Brandenburg; Alexander Alexandrov; Dorothee von Laer
Transfer of autologous gene-modified T cells in HIV-infected patients with advanced immunodeficiency and drug-resistant virus.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(5):1024-33.
2007: Claudia Lange; Zhixiong Li; Lubin Fang; Christopher Baum; Boris Fehse
CD34 modulates the trafficking behavior of hematopoietic cells in vivo.
Stem cells and development 2007;16(2):297-304.
2007: Elke Will; Jeff Bailey; Todd Schuesler; Ute Modlich; Brenden Balcik; Ben Burzynski; David Witte; Gerlinde Layh-Schmitt; Cornelia Rudolph; Brigitte Schlegelberger; Christof von Kalle; Christopher Baum; Brian P Sorrentino; Lars M Wagner; Patrick Kelly; Lilith Reeves; David A Williams
Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trials.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(4):782-91.
2007: Olga S Kustikova; Hartmut Geiger; Zhixiong Li; Martijn Brugman; Stuart M Chambers; Chad A Shaw; Karin Pike-Overzet; Dick de Ridder; Frank Staal; Gottfried von Keudell; Kerstin Cornils; Kalpana J Nattamai; Ute Modlich; Gerard Wagemaker; Margaret A Goodell; Boris Fehse; Christopher Baum
Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.
Blood 2007;109(5):1897-907.
2006: Janine Kraunus; Daniela Zychlinski; Tilman Heise; Melanie Galla; Jens Bohne; Christopher Baum
Murine leukemia virus regulates alternative splicing through sequences upstream of the 5' splice site.
The Journal of biological chemistry 2006;281(49):37381-90.
2006: Axel Schambach; D Mueller; Melanie Galla; M M A Verstegen; Gerard Wagemaker; R Loew; Christopher Baum; Jens Bohne
Overcoming promoter competition in packaging cells improves production of self-inactivating retroviral vectors.
Gene therapy 2006;13(21):1524-33.
2006: Ute Modlich; Jens Bohne; Manfred Schmidt; Christof von Kalle; Sabine Knöss; Axel Schambach; Christopher Baum
Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity.
Blood 2006;108(8):2545-53.
2006: Julia Skokowa; Gunnar Cario; Murat Uenalan; Axel Schambach; Manuela Germeshausen; Karin Battmer; Cornelia Zeidler; Ulrich Lehmann; Matthias Eder; Christopher Baum; Rudolf Grosschedl; Martin Stanulla; Michaela Scherr; Karl Welte
LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia.
Nature medicine 2006;12(10):1191-7.
2006: Adrian J Thrasher; H Bobby Gaspar; Christopher Baum; Ute Modlich; Axel Schambach; Fabio Candotti; Makoto Otsu; Brian P Sorrentino; Linda Scobie; Ewan Cameron; Karen Blyth; Jim Neil; Salima Hacein-Bey Abina; Marina Cavazzana-Calvo; Alain Fischer
Gene therapy: X-SCID transgene leukaemogenicity.
Nature 2006;443(7109):E5-6; discussion E6-7.
2006: Axel Schambach; Bernhard Schiedlmeier; Klaus Kühlcke; M Verstegen; Geoffrey P Margison; Zhixiong Li; K Kamino; Jens Bohne; Alexander Alexandrov; Felix Hermann; Dorothee von Laer; Christopher Baum
Towards hematopoietic stem cell-mediated protection against infection with human immunodeficiency virus.
Gene therapy 2006;13(13):1037-47.
2006: Christopher Baum; Axel Schambach; Jens Bohne; Melanie Galla
Retrovirus vectors: toward the plentivirus?
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(6):1050-63.
2006: Axel Schambach; Melanie Galla; Ute Modlich; Elke Will; Saurabh Chandra; Lilith Reeves; Melissa Colbert; David A Williams; Christof von Kalle; Christopher Baum
Lentiviral vectors pseudotyped with murine ecotropic envelope: increased biosafety and convenience in preclinical research.
Experimental hematology 2006;34(5):588-92.
2006: Axel Schambach; Jens Bohne; Christopher Baum; Felix Hermann; L Egerer; Dorothee von Laer; Tsanan Giroglou
Woodchuck hepatitis virus post-transcriptional regulatory element deleted from X protein and promoter sequences enhances retroviral vector titer and expression.
Gene therapy 2006;13(7):641-5.
2006: Christopher Baum; Olga S Kustikova; Ute Modlich; Zhixiong Li; Boris Fehse
Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors.
Human gene therapy 2006;17(3):253-63.
2006: Axel Schambach; Jens Bohne; Saurabh Chandra; Elke Will; Geoffrey P Margison; David A Williams; Christopher Baum
Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(2):391-400.
2006: Elke Will; Daniel Speidel; Zheng Wang; Gabriel Ghiaur; Andreas Rimek; Bernhard Schiedlmeier; David A Williams; Christopher Baum; Wolfram Ostertag; Hannes Klump
HOXB4 inhibits cell growth in a dose-dependent manner and sensitizes cells towards extrinsic cues.
Cell cycle (Georgetown, Tex.) 2006;5(1):14-22.
2005: Gernot Beutel; Johann Meyer; Liping Ma; Songmei Yin; Matthias Eder; Nils von neuhoff; Ludwig Wilkens; Jing Wei; Bernd Hertenstein; Gerhard Heil; Brigitte Schlegelberger; Arnold Ganser; Zhixiong Li; Christopher Baum
Expression of the p75 neurotrophin receptor in acute leukaemia.
British journal of haematology 2005;131(1):67-70.
2005: Sandra Pilat; Sebastian Carotta; Bernhard Schiedlmeier; Kenji Kamino; Andreas Mairhofer; Elke Will; Ute Modlich; Peter Steinlein; Wolfram Ostertag; Christopher Baum; Hartmut Beug; Hannes Klump
HOXB4 enforces equivalent fates of ES-cell-derived and adult hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(34):12101-6.
2005: Hannes Klump; Bernhard Schiedlmeier; Christopher Baum
Control of self-renewal and differentiation of hematopoietic stem cells: HOXB4 on the threshold.
Annals of the New York Academy of Sciences 2005;1044():6-15.
2005: Ute Modlich; Olga S Kustikova; Manfred Schmidt; Cornelia Rudolph; Johann Meyer; Zhixiong Li; Kenji Kamino; Nils von neuhoff; Brigitte Schlegelberger; Klaus Kuehlcke; Kevin D Bunting; Sonja Schmidt; Annette Deichmann; Christof von Kalle; Boris Fehse; Christopher Baum
Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.
Blood 2005;105(11):4235-46.
2005: Olga S Kustikova; Boris Fehse; Ute Modlich; Min Yang; Jochen Düllmann; Kenji Kamino; Nils von neuhoff; Brigitte Schlegelberger; Zhixiong Li; Christopher Baum
Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking.
Science (New York, N.Y.) 2005;308(5725):1171-4.
2004: Oliver Frank; Cornelia Rudolph; Christoph Heberlein; Nils von neuhoff; Evelin Schröck; Axel Schambach; Brigitte Schlegelberger; Boris Fehse; Wolfram Ostertag; Carol Stocking; Christopher Baum
Tumor cells escape suicide gene therapy by genetic and epigenetic instability.
Blood 2004;104(12):3543-9.
2004: Janine Kraunus; D H S Schaumann; Johann Meyer; Ute Modlich; Boris Fehse; Gunda Brandenburg; Dorothee von Laer; Hannes Klump; Axel Schambach; Jens Bohne; Christopher Baum
Self-inactivating retroviral vectors with improved RNA processing.
Gene therapy 2004;11(21):1568-78.
2004: Melanie Galla; Elke Will; Janine Kraunus; Lei Chen; Christopher Baum
Retroviral pseudotransduction for targeted cell manipulation.
Molecular cell 2004;16(2):309-15.
2004: Christof von Kalle; B Fehse; Gerlinde Layh-Schmitt; M Schmidt; Patrick Kelly; Christopher Baum
Stem cell clonality and genotoxicity in hematopoietic cells: gene activation side effects should be avoidable.
Seminars in hematology 2004;41(4):303-18.
2004: Zhixiong Li; Ute Modlich; Christopher Baum
Safety and efficacy in retrovirally modified haematopoietic cell therapy.
Best practice & research. Clinical haematology 2004;17(3):493-503.
2004: Boris Fehse; Olga S Kustikova; M Bubenheim; Christopher Baum
Pois(s)on--it's a question of dose...
Gene therapy 2004;11(11):879-81.
2004: Rainer Loew; Nathalie Selevsek; Boris Fehse; Dorothee von Laer; Christopher Baum; Axel A Fauser; Klaus Kuehlcke
Simplified generation of high-titer retrovirus producer cells for clinically relevant retroviral vectors by reversible inclusion of a lox-P-flanked marker gene.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(5):738-46.
2004: Christoph Klein; Christopher Baum
Gene therapy for inherited disorders of haematopoietic cells.
The hematology journal : the official journal of the European Haematology Association / EHA 2004;5(2):103-11.
2004: Christopher Baum; Christof von Kalle; Frank Staal; Zhixiong Li; Boris Fehse; Manfred Schmidt; Floor Weerkamp; Stefan Karlsson; Gerard Wagemaker; David A Williams
Chance or necessity? Insertional mutagenesis in gene therapy and its consequences.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(1):5-13.
2004: Marc Egelhofer; Gunda Brandenburg; Holger Martinius; Patricia Schult-Dietrich; Gregory Melikian; Renate Kunert; Christopher Baum; Ingrid Choi; Alexander Alexandrov; Dorothee von Laer
Inhibition of human immunodeficiency virus type 1 entry in cells expressing gp41-derived peptides.
Journal of virology 2004;78(2):568-75.
2003: Zhixiong Li; Maike Schwieger; Claudia Lange; Janine Kraunus; Hanying Sun; Eric van den Akker; Ute Modlich; Ebru Serinsöz; Elke Will; Dorothee von Laer; Carol Stocking; Boris Fehse; Bernhard Schiedlmeier; Christopher Baum
Predictable and efficient retroviral gene transfer into murine bone marrow repopulating cells using a defined vector dose.
Experimental hematology 2003;31(12):1206-14.
2003: Olga S Kustikova; Anke Wahlers; Klaus Kuhlcke; Birgit Stahle; Axel R Zander; Christopher Baum; Boris Fehse
Dose finding with retroviral vectors: correlation of retroviral vector copy numbers in single cells with gene transfer efficiency in a cell population.
Blood 2003;102(12):3934-7.
2003: David A Williams; Christopher Baum
Medicine. Gene therapy--new challenges ahead.
Science (New York, N.Y.) 2003;302(5644):400-1.
2003: Christopher Baum; Boris Fehse
Mutagenesis by retroviral transgene insertion: risk assessment and potential alternatives.
Current opinion in molecular therapeutics 2003;5(5):458-62.
2003: Jana Cmejlova; M Hildinger; Radek Cmejla; Ota Fuchs; D Kalabova; Christopher Baum; Jaroslav Jelinek
Impact of splice-site mutations of the human MDR1 cDNA on its stability and expression following retroviral gene transfer.
Gene therapy 2003;10(12):1061-5.
2003: Christopher Baum; Jochen Düllmann; Zhixiong Li; Boris Fehse; Johann Meyer; David A Williams; Christof von Kalle
Side effects of retroviral gene transfer into hematopoietic stem cells.
Blood 2003;101(6):2099-114.
2003: Bernhard Schiedlmeier; Hannes Klump; Elke Will; Gökhan Arman-Kalcek; Zhixiong Li; Zheng Wang; Andreas Rimek; Jutta Friel; Christopher Baum; Wolfram Ostertag
High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation.
Blood 2003;101(5):1759-68.
2003: Christopher Baum; Christof von Kalle
Gene therapy targeting hematopoietic cells: better not leave it to chance.
Acta haematologica 2003;110(2-3):107-9.
2002: Boris Fehse; Olga S Kustikova; Zhixiong Li; Anke Wahlers; Wolfgang Bohn; W R Beyer; D Chalmers; P Tiberghien; Klaus Kühlcke; Axel R Zander; Christopher Baum
A novel 'sort-suicide' fusion gene vector for T cell manipulation.
Gene therapy 2002;9(23):1633-8.
2002: Stephanie Laufs; Christopher Baum; Stefan Fruehauf
Transplantation of human hematopoietic progenitor cells transduced with a retroviral vector containing the human multidrug-resistance-1 gene for myeloprotective gene therapy.
Transplantation proceedings 2002;34(6):2325-9.
2002: Anke Wahlers; Olga S Kustikova; Peter F Zipfel; Katsuhiko Itoh; Markus Koester; Christoph Heberlein; Zhixiong Li; Bernhard Schiedlmeier; Christine Skerka; Boris Fehse; Christopher Baum
Upstream conserved sequences of mouse leukemia viruses are important for high transgene expression in lymphoid and hematopoietic cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(3):313-20.
2002: Zhixiong Li; Boris Fehse; Bernhard Schiedlmeier; Jochen Düllmann; O Frank; A R Zander; Wolfram Ostertag; Christopher Baum
Persisting multilineage transgene expression in the clonal progeny of a hematopoietic stem cell.
Leukemia 2002;16(9):1655-63.
2002: Elke Will; Hannes Klump; Nicole Heffner; Maike Schwieger; Bernhard Schiedlmeier; Wolfram Ostertag; Christopher Baum; Carol Stocking
Unmodified Cre recombinase crosses the membrane.
Nucleic acids research 2002;30(12):e59.
2002: Zhixiong Li; Jochen Düllmann; Bernhard Schiedlmeier; Manfred Schmidt; Christof von Kalle; Johann Meyer; Martin Forster; Carol Stocking; Anke Wahlers; Oliver Frank; Wolfram Ostertag; Klaus Kühlcke; Hans-Georg Eckert; Boris Fehse; Christopher Baum
Murine leukemia induced by retroviral gene marking.
Science (New York, N.Y.) 2002;296(5567):497.
2002: Alexander Carpinteiro; Stefan Peinert; Wolfram Ostertag; Axel R Zander; Dieter K Hossfeld; Klaus Kühlcke; Hans-Georg Eckert; Christopher Baum; Susanna Hegewisch-Becker
Genetic protection of repopulating hematopoietic cells with an improved MDR1-retrovirus allows administration of intensified chemotherapy following stem cell transplantation in mice.
International journal of cancer. Journal international du cancer 2002;98(5):785-92.
2002: Ursula Valentiner; Uwe Steffen Pfueller; Christopher Baum; Udo Schumacher
The cytotoxic effect of mistletoe lectins I, II and III on sensitive and multidrug resistant human colon cancer cell lines in vitro.
Toxicology 2002;171(2-3):187-99.
2002: Carsten Lindemann; Andrea Schilz; Barbara Emons; Christopher Baum; Rainer Löw; Axel A Fauser; Klaus Kuehlcke; Hans-Georg Eckert
Down-regulation of retroviral transgene expression during differentiation of progenitor-derived dendritic cells.
Experimental hematology 2002;30(2):150-7.
2002: Bernhard Schiedlmeier; Andrea Schilz; Klaus Kühlcke; Stephanie Laufs; Christopher Baum; W Jens Zeller; Hans-Georg Eckert; Stefan Fruehauf
Multidrug resistance 1 gene transfer can confer chemoprotection to human peripheral blood progenitor cells engrafted in immunodeficient mice.
Human gene therapy 2002;13(2):233-42.
2002: Anke Wahlers; Peter F Zipfel; Maike Schwieger; Wolfram Ostertag; Christopher Baum
In vivo analysis of retroviral enhancer mutations in hematopoietic cells: SP1/EGR1 and ETS/GATA motifs contribute to long terminal repeat specificity.
Journal of virology 2002;76(1):303-12.
2001: Hannes Klump; Bernhard Schiedlmeier; B Vogt; M Ryan; Wolfram Ostertag; Christopher Baum
Retroviral vector-mediated expression of HoxB4 in hematopoietic cells using a novel coexpression strategy.
Gene therapy 2001;8(10):811-7.
2001: Anke Wahlers; Maike Schwieger; Zhixiong Li; D Meier-Tackmann; Carsten Lindemann; Hans-Georg Eckert; Dorothee von Laer; Christopher Baum
Influence of multiplicity of infection and protein stability on retroviral vector-mediated gene expression in hematopoietic cells.
Gene therapy 2001;8(6):477-86.
2001: B Vogt; Susanne Roscher; B Abel; M Hildinger; A Lamarre; Christopher Baum; Dorothee von Laer
Lack of superinfection interference in retroviral vector producer cells.
Human gene therapy 2001;12(4):359-65.
2001: R Knipper; Klaus Kuehlcke; Bernhard Schiedlmeier; M Hildinger; Carsten Lindemann; Andrea Schilz; Axel A Fauser; Stefan Fruehauf; W Jens Zeller; Wolfram Ostertag; Hans-Georg Eckert; Christopher Baum
Improved post-transcriptional processing of an MDR1 retrovirus elevates expression of multidrug resistance in primary human hematopoietic cells.
Gene therapy 2001;8(3):239-46.
2000: Andrea Schilz; Bernhard Schiedlmeier; Klaus Kühlcke; Stefan Fruehauf; Carsten Lindemann; W Jens Zeller; Manuel Grez; Axel A Fauser; Christopher Baum; Hans-Georg Eckert
MDR1 gene expression in NOD/SCID repopulating cells after retroviral gene transfer under clinically relevant conditions.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(6):609-18.
2000: Axel Schambach; Harald Wodrich; M Hildinger; Jens Bohne; Hans-Georg Kräusslich; Christopher Baum
Context dependence of different modules for posttranscriptional enhancement of gene expression from retroviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(5):435-45.
2000: SD Turner; Joseph Rafferty; Leslie J Fairbairn; J Ashby; H Tinwell; Hans-Georg Eckert; Christopher Baum; Linda S Lashford
The effects of dose, route of administration, drug scheduling and MDR-1 gene transfer on the genotoxicity of etoposide in bone marrow.
Leukemia 2000;14(10):1796-802.
2000: Boris Fehse; A Richters; K Putimtseva-Scharf; Hannes Klump; Zhixiong Li; Wolfram Ostertag; Axel R Zander; Christopher Baum
CD34 splice variant: an attractive marker for selection of gene-modified cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(5 Pt 1):448-56.
2000: Bernhard Schiedlmeier; K Wermann; Klaus Kühlcke; Hans-Georg Eckert; Christopher Baum; Stefan Fruehauf; W Jens Zeller
Human multidrug resistance-1 gene transfer to long-term repopulating human mobilized peripheral blood progenitor cells.
Bone marrow transplantation 2000;25 Suppl 2():S118-24.
2000: Hans-Georg Eckert; Klaus Kühlcke; Andrea Schilz; Carsten Lindemann; Nadezda Basara; Axel A Fauser; Christopher Baum
Clinical scale production of an improved retroviral vector expressing the human multidrug resistance 1 gene (MDR1).
Bone marrow transplantation 2000;25 Suppl 2():S114-7.
2000: Dorothee von Laer; A Corovic; B Vogt; Uwe Herwig; Susanne Roscher; Boris Fehse; Christopher Baum
Amphotropic and VSV-G-pseudotyped retroviral vectors transduce human hematopoietic progenitor cells with similar efficiency.
Bone marrow transplantation 2000;25 Suppl 2():S75-9.
2000: Christopher Baum; Stefan Peinert; A Carpinteiro; Hans-Georg Eckert; Leslie J Fairbairn
Genetic modification of haematopoietic cells for combined resistance to podophyllotoxins, other agents covered by MDR1-mediated efflux activity and nitrosoureas.
Bone marrow transplantation 2000;25 Suppl 2():S71-4.
2000: Dorothee von Laer; A Corovic; B Vogt; Boris Fehse; Susanne Roscher; Andreas Rimek; Christopher Baum; Wolfram Ostertag
Loss of CD38 antigen on CD34+CD38+ cells during short-term culture.
Leukemia 2000;14(5):947-8.
2000: Bernhard Schiedlmeier; Klaus Kühlcke; Hans-Georg Eckert; Christopher Baum; W Jens Zeller; Stefan Fruehauf
Quantitative assessment of retroviral transfer of the human multidrug resistance 1 gene to human mobilized peripheral blood progenitor cells engrafted in nonobese diabetic/severe combined immunodeficient mice.
Blood 2000;95(4):1237-48.
1999: Christopher Baum; A Richters; Wolfram Ostertag
Retroviral vector-mediated gene expression in hematopoietic cells.
Current opinion in molecular therapeutics 1999;1(5):605-12.
1999: Christopher Baum; Leslie J Fairbairn; M Hildinger; Linda S Lashford; Susanna Hegewisch-Becker; Joseph Rafferty
New perspectives for cancer chemotherapy by genetic protection of haematopoietic cells.
Expert reviews in molecular medicine 1999;1999():1-28.
1999: Jaroslav Jelinek; Joseph Rafferty; Radek Cmejla; M Hildinger; Dhanalakshmi Chinnasamy; Linda S Lashford; Wolfram Ostertag; Geoffrey P Margison; TM Dexter; Leslie J Fairbairn; Christopher Baum
A novel dual function retrovirus expressing multidrug resistance 1 and O6-alkylguanine-DNA-alkyltransferase for engineering resistance of haemopoietic progenitor cells to multiple chemotherapeutic agents.
Gene therapy 1999;6(8):1489-93.
1999: M Hildinger; Andrea Schilz; Hans-Georg Eckert; Wolfgang Bohn; Boris Fehse; Axel Zander; Wolfram Ostertag; Christopher Baum
Bicistronic retroviral vectors for combining myeloprotection with cell-surface marking.
Gene therapy 1999;6(7):1222-30.
1999: Hrvoje Miletic; Michael Bruns; K Tsiakas; B Vogt; R Rezai; Christopher Baum; K Kühlke; F L Cosset; Wolfram Ostertag; Heinz Lother; Dorothee von Laer
Retroviral vectors pseudotyped with lymphocytic choriomeningitis virus.
Journal of virology 1999;73(7):6114-6.
1999: M Hildinger; K L Abel; Wolfram Ostertag; Christopher Baum
Design of 5' untranslated sequences in retroviral vectors developed for medical use.
Journal of virology 1999;73(5):4083-9.
1998: M Hildinger; Hans-Georg Eckert; Andrea Schilz; J John; Wolfram Ostertag; Christopher Baum
FMEV vectors: both retroviral long terminal repeat and leader are important for high expression in transduced hematopoietic cells.
Gene therapy 1998;5(11):1575-9.
1998: Christopher Baum; N Hunt; M Hildinger; Hans-Georg Eckert; Holm Zaehres; A Richters; J John; Jürgen Löhler; Wolfram Ostertag
cis-Active elements of Friend spleen focus-forming virus: from disease induction to disease prevention.
Acta haematologica 1998;99(3):156-64.
1998: M Hildinger; Boris Fehse; Susanna Hegewisch-Becker; J John; J R Rafferty; Wolfram Ostertag; Christopher Baum
Dominant selection of hematopoietic progenitor cells with retroviral MDR1 co-expression vectors.
Human gene therapy 1998;9(1):33-42.
1997: Christopher Baum; Katsuhiko Itoh; Johann Meyer; Christine Laker; Y Ito; Wolfram Ostertag
The potent enhancer activity of the polycythemic strain of spleen focus-forming virus in hematopoietic cells is governed by a binding site for Sp1 in the upstream control region and by a unique enhancer core motif, creating an exclusive target for PEBP/CBF.
Journal of virology 1997;71(9):6323-31.
1996: Hans-Georg Eckert; Marcus Stockschläder; U Just; Susanna Hegewisch-Becker; M Grez; A Uhde; Axel Zander; Wolfram Ostertag; Christopher Baum
High-dose multidrug resistance in primary human hematopoietic progenitor cells transduced with optimized retroviral vectors.
Blood 1996;88(9):3407-15.
1996: Christopher Baum; Hans-Georg Eckert; Marcus Stockschläder; U Just; Susanna Hegewisch-Becker; M Hildinger; A Uhde; J John; Wolfram Ostertag
Improved retroviral vectors for hematopoietic stem cell protection and in vivo selection.
Journal of hematotherapy 1996;5(4):323-9.
1996: Christopher Baum; Hans-Georg Eckert; Carol Stocking; Wolfram Ostertag
Activity of Friend mink cell focus-forming retrovirus during myelo-erythroid hematopoiesis.
Experimental hematology 1996;24(2):364-70.
1996: Christopher Baum; Geoffrey P Margison; Hans-Georg Eckert; Leslie J Fairbairn; Wolfram Ostertag; Joseph Rafferty
Gene transfer to augment the therapeutic index of anticancer chemotherapy.
Gene therapy 1996;3(1):1-3.
1995: Christopher Baum; Susanna Hegewisch-Becker; Hans-Georg Eckert; Carol Stocking; Wolfram Ostertag
Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells.
Journal of virology 1995;69(12):7541-7.
1994: Christopher Baum; P Forster; Susanna Hegewisch-Becker; K Harbers
An optimized electroporation protocol applicable to a wide range of cell lines.
BioTechniques 1994;17(6):1058-62.