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Richard McClelland

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Alex W White; Nicholas Carpenter; Jerome R P Lottin; Richard A McClelland; Robert I Nicholson
Synthesis and evaluation of novel anti-proliferative pyrroloazepinone and indoloazepinone oximes derived from the marine natural product hymenialdisine.
Andrew Stone; Robert L Sutherland; Fatima Valdés-Mora; Carol M Dutkowski; Lynne Farrow; Heidi Fiegl; Julia M W Gee; Richard A McClelland; Rachael A McCloy; Elizabeth A Musgrove; Robert I Nicholson
Tamoxifen-induced epigenetic silencing of oestrogen-regulated genes in anti-hormone resistant breast cancer.
Iain R Hutcheson; Janice M Knowlden; Richard A McClelland; Robert I Nicholson; Denise Barrow; Hayley E Francies; Lindy Goddard; J M W Gee
Fulvestrant-induced expression of ErbB3 and ErbB4 receptors sensitizes oestrogen receptor-positive breast cancer cells to heregulin β1.

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All Publications

2012: Alex W White; Nicholas Carpenter; Jerome R P Lottin; Richard A McClelland; Robert I Nicholson
Synthesis and evaluation of novel anti-proliferative pyrroloazepinone and indoloazepinone oximes derived from the marine natural product hymenialdisine.
European journal of medicinal chemistry 2012;56():246-53.
2012: Andrew Stone; Robert L Sutherland; Fatima Valdés-Mora; Carol M Dutkowski; Lynne Farrow; Heidi Fiegl; Julia M W Gee; Richard A McClelland; Rachael A McCloy; Elizabeth A Musgrove; Robert I Nicholson
Tamoxifen-induced epigenetic silencing of oestrogen-regulated genes in anti-hormone resistant breast cancer.
PloS one 2012;7(7):e40466.
2011: Iain R Hutcheson; Janice M Knowlden; Richard A McClelland; Robert I Nicholson; Denise Barrow; Hayley E Francies; Lindy Goddard; J M W Gee
Fulvestrant-induced expression of ErbB3 and ErbB4 receptors sensitizes oestrogen receptor-positive breast cancer cells to heregulin β1.
Breast cancer research : BCR 2011;13(2):R29.
2006: Iain R Hutcheson; Janice M Knowlden; Helen E Jones; Rajpal S Burmi; Richard A McClelland; Denise Barrow; J M W Gee; Robert I Nicholson
Inductive mechanisms limiting response to anti-epidermal growth factor receptor therapy.
Endocrine-related cancer 2006;13 Suppl 1():S89-97.
2006: J M W Gee; V E Shaw; Stephen Hiscox; Richard A McClelland; Neil K Rushmere; Robert I Nicholson
Deciphering antihormone-induced compensatory mechanisms in breast cancer and their therapeutic implications.
Endocrine-related cancer 2006;13 Suppl 1():S77-88.
2006: D J Britton; Iain R Hutcheson; Janice M Knowlden; Denise Barrow; M Giles; Richard A McClelland; J M W Gee; Robert I Nicholson
Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth.
Breast cancer research and treatment 2006;96(2):131-46.
2003: J M W Gee; Maureen E Harper; Iain R Hutcheson; Tracie-Ann Madden; Denise Barrow; Janice M Knowlden; Richard A McClelland; Nicola J Jordan; Alan E Wakeling; Robert I Nicholson
The antiepidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves antihormone response and prevents development of resistance in breast cancer in vitro.
Endocrinology 2003;144(11):5105-17.
2002: Robert I Nicholson; Iain R Hutcheson; Maureen E Harper; Janice M Knowlden; Denise Barrow; Richard A McClelland; Helen E Jones; Alan E Wakeling; J M W Gee
Modulation of epidermal growth factor receptor in endocrine-resistant, estrogen-receptor-positive breast cancer.
Annals of the New York Academy of Sciences 2002;963():104-15.
2001: Robert I Nicholson; Iain R Hutcheson; Maureen E Harper; Janice M Knowlden; Denise Barrow; Richard A McClelland; Helen E Jones; Alan E Wakeling; J M W Gee
Modulation of epidermal growth factor receptor in endocrine-resistant, oestrogen receptor-positive breast cancer.
Endocrine-related cancer 2001;8(3):175-82.
2001: Richard A McClelland; Denise Barrow; Tracie-Ann Madden; Carol M Dutkowski; J Pamment; Janice M Knowlden; J M W Gee; Robert I Nicholson
Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex).
Endocrinology 2001;142(7):2776-88.
2000: Tracie-Ann Madden; Denise Barrow; Richard A McClelland; J M W Gee; Robert I Nicholson
Modulation of oestrogen action by receptor gene inhibition.
European journal of cancer (Oxford, England : 1990) 2000;36 Suppl 4():S34-5.
1999: Robert I Nicholson; Richard A McClelland; John F R Robertson; J M W Gee
Involvement of steroid hormone and growth factor cross-talk in endocrine response in breast cancer.
Endocrine-related cancer 1999;6(3):373-87.
1999: Richard A McClelland; J M W Gee; L O'Sullivan; D M Barnes; John F R Robertson; Ian O Ellis; Robert I Nicholson
p21(WAF1) expression and endocrine response in breast cancer.
The Journal of pathology 1999;188(2):126-32.
1998: Rina Hui; J R Ball; R D Macmillan; FS Kenny; Owen W J Prall; DH Campbell; AL Cornish; Richard A McClelland; Roger J Daly; J F Forbes; Roger W Blamey; Elizabeth A Musgrove; John F R Robertson; Robert I Nicholson; Robert L Sutherland
EMS1 gene expression in primary breast cancer: relationship to cyclin D1 and oestrogen receptor expression and patient survival.
Oncogene 1998;17(8):1053-9.
1998: Richard A McClelland; DL Manning; J M W Gee; PC Willsher; John F R Robertson; Ian O Ellis; Roger W Blamey; Robert I Nicholson
Oestrogen-regulated genes in breast cancer: association of pLIV1 with response to endocrine therapy.
British journal of cancer 1998;77(10):1653-6.
1997: Janice M Knowlden; J M W Gee; S Bryant; Richard A McClelland; DL Manning; Robert E Mansel; Ian O Ellis; Roger W Blamey; John F R Robertson; Robert I Nicholson
Use of reverse transcription-polymerase chain reaction methodology to detect estrogen-regulated gene expression in small breast cancer specimens.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(11):2165-72.
1996: Robert I Nicholson; J M W Gee; S Bryant; A B Francis; Richard A McClelland; Janice M Knowlden; A E Wakeling; C Kent Osborne
Pure antiestrogens. The most important advance in the endocrine therapy of breast cancer since 1896.
Annals of the New York Academy of Sciences 1996;784():325-35.
1996: Richard A McClelland; J M W Gee; A B Francis; John F R Robertson; Roger W Blamey; A E Wakeling; Robert I Nicholson
Short-term effects of pure anti-oestrogen ICI 182780 treatment on oestrogen receptor, epidermal growth factor receptor and transforming growth factor-alpha protein expression in human breast cancer.
European journal of cancer (Oxford, England : 1990) 1996;32A(3):413-6.
1996: Richard A McClelland; DL Manning; J M W Gee; E Anderson; R Clarke; A Howell; M Dowsett; John F R Robertson; Roger W Blamey; A E Wakeling; Robert I Nicholson
Effects of short-term antiestrogen treatment of primary breast cancer on estrogen receptor mRNA and protein expression and on estrogen-regulated genes.
Breast cancer research and treatment 1996;41(1):31-41.
1995: Robert I Nicholson; Richard A McClelland; J M W Gee
Steroid hormone receptors and their clinical significance in cancer.
Journal of clinical pathology 1995;48(10):890-5.
1995: J M W Gee; Ian O Ellis; John F R Robertson; PC Willsher; Richard A McClelland; K N Hewitt; Roger W Blamey; Robert I Nicholson
Immunocytochemical localization of Fos protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy.
International journal of cancer. Journal international du cancer 1995;64(4):269-73.
1995: DL Manning; Richard A McClelland; Janice M Knowlden; S Bryant; J M W Gee; Chris D Green; John F R Robertson; Roger W Blamey; Robert L Sutherland; Christopher J Ormandy
Differential expression of oestrogen regulated genes in breast cancer.
Acta oncologica (Stockholm, Sweden) 1995;34(5):641-6.
1994: J M W Gee; John F R Robertson; Ian O Ellis; PC Willsher; Richard A McClelland; H B Hoyle; S R Kyme; P Finlay; Roger W Blamey; Robert I Nicholson
Immunocytochemical localization of BCL-2 protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy.
International journal of cancer. Journal international du cancer 1994;59(5):619-28.
1994: Robert I Nicholson; Richard A McClelland; J M W Gee; DL Manning; P Cannon; John F R Robertson; Ian O Ellis; Roger W Blamey
Transforming growth factor-alpha and endocrine sensitivity in breast cancer.
Cancer research 1994;54(7):1684-9.
1994: A K Sharma; Kieran Horgan; Richard A McClelland; Anthony Douglas-Jones; Ton van Agthoven; Lambert C J Dorssers; Robert I Nicholson
A dual immunocytochemical assay for oestrogen and epidermal growth factor receptors in tumour cell lines.
The Histochemical journal 1994;26(4):306-10.
1994: DL Manning; John F R Robertson; Ian O Ellis; C W Elston; Richard A McClelland; J M W Gee; R J Jones; Chris D Green; P Cannon; Roger W Blamey
Oestrogen-regulated genes in breast cancer: association of pLIV1 with lymph node involvement.
European journal of cancer (Oxford, England : 1990) 1994;30A(5):675-8.
1994: Robert I Nicholson; Richard A McClelland; J M W Gee; DL Manning; P Cannon; John F R Robertson; Ian O Ellis; Roger W Blamey
Epidermal growth factor receptor expression in breast cancer: association with response to endocrine therapy.
Breast cancer research and treatment 1994;29(1):117-25.
1993: DL Manning; Richard A McClelland; J M W Gee; C M Chan; Chris D Green; Roger W Blamey; Robert I Nicholson
The role of four oestrogen-responsive genes, pLIV1, pS2, pSYD3 and pSYD8, in predicting responsiveness to endocrine therapy in primary breast cancer.
European journal of cancer (Oxford, England : 1990) 1993;29A(10):1462-8.
1993: Robert I Nicholson; Richard A McClelland; P Finlay; C L Eaton; W J Gullick; A R Dixon; John F R Robertson; Ian O Ellis; Roger W Blamey
Relationship between EGF-R, c-erbB-2 protein expression and Ki67 immunostaining in breast cancer and hormone sensitivity.
European journal of cancer (Oxford, England : 1990) 1993;29A(7):1018-23.
1992: K J Walker; Richard A McClelland; W Candlish; Roger W Blamey; Robert I Nicholson
Heterogeneity of oestrogen receptor expression in normal and malignant breast tissue.
European journal of cancer (Oxford, England : 1990) 1992;28(1):34-7.
1991: Richard A McClelland; D Wilson; R Leake; P Finlay; Robert I Nicholson
A multicentre study into the reliability of steroid receptor immunocytochemical assay quantification. British Quality Control Group.
European journal of cancer (Oxford, England : 1990) 1991;27(6):711-5.
1990: Robert I Nicholson; K J Walker; Richard A McClelland; A Dixon; John F R Robertson; Roger W Blamey
Zoladex plus tamoxifen versus Zoladex alone in pre- and peri-menopausal metastatic breast cancer.
The Journal of steroid biochemistry and molecular biology 1990;37(6):989-95.
1990: Richard A McClelland; P Finlay; K J Walker; D Nicholson; John F R Robertson; Roger W Blamey; Robert I Nicholson
Automated quantitation of immunocytochemically localized estrogen receptors in human breast cancer.
Cancer research 1990;50(12):3545-50.