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Neville McClenaghan

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Hong Guo-Parke; Muhajir Hamid; Catriona Kelly; Neville H McClenaghan; Jane T McCluskey; Peter R Flatt
Configuration of electrofusion-derived human insulin-secreting cell line as pseudoislets enhances functionality and therapeutic utility.
Arif Abed; Charlotte Critchlow; Peter R Flatt; Neville H McClenaghan; Catriona Kelly
Directed differentiation of progenitor cells towards an islet-cell phenotype.
Mauricio S Krause; Neville H McClenaghan; Colin Murphy; Peter R Flatt; Paulo I Homem de Bittencourt; Philip Newsholme
L-arginine is essential for pancreatic β-cell functional integrity, metabolism and defense from inflammatory challenge.

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2012: Hong Guo-Parke; Muhajir Hamid; Catriona Kelly; Neville H McClenaghan; Jane T McCluskey; Peter R Flatt
Configuration of electrofusion-derived human insulin-secreting cell line as pseudoislets enhances functionality and therapeutic utility.
The Journal of endocrinology 2012;214(3):257-65.
2012: Arif Abed; Charlotte Critchlow; Peter R Flatt; Neville H McClenaghan; Catriona Kelly
Directed differentiation of progenitor cells towards an islet-cell phenotype.
American journal of stem cells 2012;1(3):196-204.
2011: Mauricio S Krause; Neville H McClenaghan; Colin Murphy; Peter R Flatt; Paulo I Homem de Bittencourt; Philip Newsholme
L-arginine is essential for pancreatic β-cell functional integrity, metabolism and defense from inflammatory challenge.
The Journal of endocrinology 2011;211(1):87-97.
2011: Jane T McCluskey; Ramon Gomis; Hong Guo-Parke; Muhajir Hamid; Neville H McClenaghan; Peter R Flatt
Development and functional characterization of insulin-releasing human pancreatic beta cell lines produced by electrofusion.
The Journal of biological chemistry 2011;286(25):21982-92.
2011: Nigel Irwin; J M McKinney; Clifford J Bailey; Neville H McClenaghan; Peter R Flatt
Acute and long-term effects of peroxisome proliferator-activated receptor-γ activation on the function and insulin secretory responsiveness of clonal beta-cells.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2011;43(4):244-9.
2011: Catriona Kelly; Neville H McClenaghan; Peter R Flatt
Role of islet structure and cellular interactions in the control of insulin secretion.
Islets 2011;3(2):41-7.
2011: Catriona Kelly; Cara C S Flatt; Neville H McClenaghan
Stem cell-based approaches for the treatment of diabetes.
Stem cells international 2011;2011():424986.
2010: Joan M McKiney; Nigel Irwin; Peter R Flatt; Clifford J Bailey; Neville H McClenaghan
Acute and long-term effects of metformin on the function and insulin secretory responsiveness of clonal β-cells.
Biological chemistry 2010;391(12):1451-9.
2010: Catriona Kelly; Hong Guo Parke; Jane T McCluskey; Peter R Flatt; Neville H McClenaghan
The role of glucagon- and somatostatin-secreting cells in the regulation of insulin release and beta-cell function in heterotypic pseudoislets.
Diabetes/metabolism research and reviews 2010;26(7):525-33.
2010: Catriona Kelly; Hong Guo; Jane T McCluskey; Peter R Flatt; Neville H McClenaghan
Comparison of insulin release from MIN6 pseudoislets and pancreatic islets of Langerhans reveals importance of homotypic cell interactions.
Pancreas 2010;39(7):1016-23.
2010: Catriona Kelly; Peter R Flatt; Neville H McClenaghan
Cell-to-cell communication and cellular environment alter the somatostatin status of delta cells.
Biochemical and biophysical research communications 2010;399(2):162-6.
2010: Philip Newsholme; Celine Gaudel; Neville H McClenaghan
Nutrient regulation of insulin secretion and beta-cell functional integrity.
Advances in experimental medicine and biology 2010;654():91-114.
2009: Katrin Bender; Pierre Maechler; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism.
Clinical science (London, England : 1979) 2009;117(9):321-30.
2009: Aoife Kiely; Aisling Robinson; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
Toll-like receptor agonist induced changes in clonal rat BRIN-BD11 beta-cell insulin secretion and signal transduction.
The Journal of endocrinology 2009;202(3):365-73.
2009: Neville H McClenaghan; Siobhan M Scullion; Brian Mion; Chandralal Hewage; J Paul G Malthouse; Peter R Flatt; Philip Newsholme; Lorraine Brennan
Prolonged L-alanine exposure induces changes in metabolism, Ca(2+) handling and desensitization of insulin secretion in clonal pancreatic beta-cells.
Clinical science (London, England : 1979) 2009;116(4):341-51.
2007: Aoife Kiely; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
Pro-inflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic beta-cell line.
The Journal of endocrinology 2007;195(1):113-23.
2007: Steven Patterson; Peter R Flatt; Neville H McClenaghan
Major metabolic homocysteine-derivative, homocysteine thiolactone, exerts changes in pancreatic beta-cell glucose-sensing, cellular signal transduction and integrity.
Archives of biochemistry and biophysics 2007;461(2):287-93.
2007: Neville H McClenaghan
Physiological regulation of the pancreatic {beta}-cell: functional insights for understanding and therapy of diabetes.
Experimental physiology 2007;92(3):481-96.
2007: Steven Patterson; Siobhan M J Scullion; Jane T McCluskey; Peter R Flatt; Neville H McClenaghan
Prolonged exposure to homocysteine results in diminished but reversible pancreatic beta-cell responsiveness to insulinotropic agents.
Diabetes/metabolism research and reviews 2007;23(4):324-34.
2007: Steven Patterson; Peter R Flatt; Neville H McClenaghan
Homocysteine-induced impairment of insulin secretion from clonal pancreatic BRIN-BD11 beta-cells is not prevented by catalase.
Pancreas 2007;34(1):144-51.
2006: Lorraine Brennan; Chandralal Hewage; J Paul G Malthouse; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism.
The FEBS journal 2006;273(22):5160-8.
2006: Neville H McClenaghan; Peter R Flatt; Andrew Ball
Actions of glucagon-like peptide-1 on KATP channel-dependent and -independent effects of glucose, sulphonylureas and nateglinide.
The Journal of endocrinology 2006;190(3):889-96.
2006: Mary Corless; Aoife Kiely; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
Glutamine regulates expression of key transcription factor, signal transduction, metabolic gene, and protein expression in a clonal pancreatic beta-cell line.
The Journal of endocrinology 2006;190(3):719-27.
2006: Lamin Marenah; Jane T McCluskey; Yasser H A Abdel-Wahab; Finbarr P M O'Harte; Neville H McClenaghan; Peter R Flatt
A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL16), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones.
Biological chemistry 2006;387(7):941-7.
2006: Steven Patterson; Peter R Flatt; Neville H McClenaghan
Homocysteine and other structurally-diverse amino thiols can alter pancreatic beta cell function without evoking cellular damage.
Biochimica et biophysica acta 2006;1760(7):1109-14.
2006: Steven Patterson; Peter R Flatt; L Brennan; Philip Newsholme; Neville H McClenaghan
Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion.
The Journal of endocrinology 2006;189(2):301-10.
2006: Liu Hui-Kang; Brian D Green; Neville H McClenaghan; Jane T McCluskey; Peter R Flatt
Deleterious effects of supplementation with dehydroepiandrosterone sulphate or dexamethasone on rat insulin-secreting cells under in vitro culture condition.
Bioscience reports 2006;26(1):31-8.
2005: Grainne A Cunningham; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic beta-cell line and protects from pro-inflammatory cytokine-induced apoptosis.
Clinical science (London, England : 1979) 2005;109(5):447-55.
2005: Brian D Green; Liu Hui-Kang; Jane T McCluskey; Nicola A Duffy; Finbarr P M O'Harte; Neville H McClenaghan; Peter R Flatt
Function of a long-term, GLP-1-treated, insulin-secreting cell line is improved by preventing DPP IV-mediated degradation of GLP-1.
Diabetes, obesity & metabolism 2005;7(5):563-9.
2005: Andrew Ball; Peter R Flatt; Neville H McClenaghan
Alterations of insulin secretion following long-term manipulation of ATP-sensitive potassium channels by diazoxide and nateglinide.
Biochemical pharmacology 2005;69(1):59-63.
2004: Andrew Ball; Jane T McCluskey; Peter R Flatt; Neville H McClenaghan
Chronic exposure to tolbutamide and glibenclamide impairs insulin secretion but not transcription of K(ATP) channel components.
Pharmacological research : the official journal of the Italian Pharmacological Society 2004;50(1):41-6.
2004: Andrew Ball; Peter R Flatt; Neville H McClenaghan
Acute and long-term effects of nateglinide on insulin secretory pathways.
British journal of pharmacology 2004;142(2):367-73.
2004: Liu Hui-Kang; Brian D Green; Neville H McClenaghan; Jane T McCluskey; Peter R Flatt
Long-term beneficial effects of vanadate, tungstate, and molybdate on insulin secretion and function of cultured beta cells.
Pancreas 2004;28(4):364-8.
2004: Liu Hui-Kang; Brian D Green; Peter R Flatt; Neville H McClenaghan; Jane T McCluskey
Effects of long-term exposure to nicotinamide and sodium butyrate on growth, viability, and the function of clonal insulin secreting cells.
Endocrine research 2004;30(1):61-8.
2004: Gordon Dixon; John Nolan; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity.
Clinical science (London, England : 1979) 2004;106(2):191-9.
2004: Liu Hui-Kang; Brian D Green; Victor A Gault; Jane T McCluskey; Neville H McClenaghan; Finbarr P M O'Harte; Peter R Flatt
N-acetyl-GLP-1: a DPP IV-resistant analogue of glucagon-like peptide-1 (GLP-1) with improved effects on pancreatic beta-cell-associated gene expression.
Cell biology international 2004;28(1):69-73.
2003: G Dixon; J Nolan; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
A comparative study of amino acid consumption by rat islet cells and the clonal beta-cell line BRIN-BD11 - the functional significance of L-alanine.
The Journal of endocrinology 2003;179(3):447-54.
2003: L Brennan; Mary Corless; Chandralal Hewage; J Paul G Malthouse; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line.
Diabetologia 2003;46(11):1512-21.
2002: S F Picton; Jane T McCluskey; Peter R Flatt; Neville H McClenaghan
Effects of cytotoxic agents on functional integrity and antioxidant enzymes in clonal beta-cells.
Diabetes & metabolism 2002;28(6 Pt 2):3S70-7; discussion 3S108-12.
2002: Lorraine Brennan; Aine Shine; Chandralal Hewage; J Paul G Malthouse; Kevin M Brindle; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secretion.
Diabetes 2002;51(6):1714-21.
2002: SJ Conroy; I Green; G Dixon; P M Byrne; J Nolan; Yasser H A Abdel-Wahab; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
Evidence for a sustained increase in clonal beta-cell basal intracellular Ca2+ levels after incubation in the presence of newly diagnosed Type-1 diabetic patient sera. Possible role in serum-induced inhibition of insulin secretion.
The Journal of endocrinology 2002;173(1):53-62.
2002: M Hamid; Jane T McCluskey; Neville H McClenaghan; Peter R Flatt
Comparison of the secretory properties of four insulin-secreting cell lines.
Endocrine research 2002;28(1-2):35-47.
2001: M Hamid; Jane T McCluskey; Neville H McClenaghan; Peter R Flatt
Comparative functional study of clonal insulin-secreting cells cultured in five commercially available tissue culture media.
Cell transplantation 2001;10(2):153-9.
2001: Neville H McClenaghan; Andrew Ball; Peter R Flatt
Specific desensitization of sulfonylurea- but not imidazoline-induced insulin release after prolonged tolbutamide exposure.
Biochemical pharmacology 2001;61(5):527-36.
2001: S F Picton; Peter R Flatt; Neville H McClenaghan
Differential acute and long term actions of succinic acid monomethyl ester exposure on insulin-secreting BRIN-BD11 cells.
International journal of experimental diabetes research 2001;2(1):19-27.
2001: M Hamid; Jane T McCluskey; Neville H McClenaghan; Peter R Flatt
Functional examination of microencapsulated bioengineered insulin-secreting beta-cells.
Cell biology international 2001;25(6):553-6.
2000: Andrew Ball; Peter R Flatt; Neville H McClenaghan
Stimulation of insulin secretion in clonal BRIN-BD11 cells by the imidazoline derivatives KU14r and RX801080.
Pharmacological research : the official journal of the Italian Pharmacological Society 2000;42(6):575-9.
2000: Andrew Ball; Peter R Flatt; Neville H McClenaghan
Desensitization of sulphonylurea- and nutrient-induced insulin secretion following prolonged treatment with glibenclamide.
European journal of pharmacology 2000;408(3):327-33.
2000: M Hamid; Jane T McCluskey; Neville H McClenaghan; Peter R Flatt
Culture and function of electrofusion-derived clonal insulin-secreting cells immobilized on solid and macroporous microcarrier beads.
Bioscience reports 2000;20(3):167-76.
2000: Neville H McClenaghan; Andrew Ball; Peter R Flatt
Induced desensitization of the insulinotropic effects of antidiabetic drugs, BTS 67 582 and tolbutamide.
British journal of pharmacology 2000;130(2):478-84.
2000: Andrew Ball; Jane T McCluskey; Peter R Flatt; Neville H McClenaghan
Drug-induced desensitization of insulinotropic actions of sulfonylureas.
Biochemical and biophysical research communications 2000;271(1):234-9.
2000: Neville H McClenaghan; Peter R Flatt
Metabolic and K(ATP) channel-independent actions of keto acid initiators of insulin secretion.
Pancreas 2000;20(1):38-46.
1999: Neville H McClenaghan; Peter R Flatt
Physiological and pharmacological regulation of insulin release: insights offered through exploitation of insulin-secreting cell lines.
Diabetes, obesity & metabolism 1999;1(3):137-50.
1999: Neville H McClenaghan; Peter R Flatt
Glucose and non-glucidic nutrients exert permissive effects on 2-keto acid regulation of pancreatic beta-cell function.
Biochimica et biophysica acta 1999;1426(1):110-8.
1999: Neville H McClenaghan; Peter R Flatt
Engineering cultured insulin-secreting pancreatic B-cell lines.
Journal of molecular medicine (Berlin, Germany) 1999;77(1):235-43.
1998: Neville H McClenaghan; Christopher R Barnett; Peter R Flatt
Na+ cotransport by metabolizable and nonmetabolizable amino acids stimulates a glucose-regulated insulin-secretory response.
Biochemical and biophysical research communications 1998;249(2):299-303.
1998: Neville H McClenaghan; Peter R Flatt; C J Bailey
Insulin-releasing action of the novel antidiabetic agent BTS 67 582.
British journal of pharmacology 1998;123(3):400-4.
1997: Neville H McClenaghan; Christopher R Barnett; Peter R Flatt
Mechanisms of action of cationic amino acids on insulin-secreting BRIN-BD11 cells.
Biochemical Society transactions 1997;25(1):144S.
1996: Neville H McClenaghan; Christopher R Barnett; Finbarr P M O'Harte; Peter R Flatt
Mechanisms of amino acid-induced insulin secretion from the glucose-responsive BRIN-BD11 pancreatic B-cell line.
The Journal of endocrinology 1996;151(3):349-57.
1996: Yasser H A Abdel-Wahab; Finbarr P M O'Harte; H Ratcliff; Neville H McClenaghan; Christopher R Barnett; Peter R Flatt
Glycation of insulin in the islets of Langerhans of normal and diabetic animals.
Diabetes 1996;45(11):1489-96.
1996: Neville H McClenaghan; Christopher R Barnett; E Ah-Sing; Yasser H A Abdel-Wahab; Finbarr P M O'Harte; T W Yoon; S K Swanston-Flatt; Peter R Flatt
Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion.
Diabetes 1996;45(8):1132-40.
1996: Neville H McClenaghan; AM Gray; Christopher R Barnett; Peter R Flatt
Hexose recognition by insulin-secreting BRIN-BD11 cells.
Biochemical and biophysical research communications 1996;223(3):724-8.
1996: Joanne Rasschaert; P R Flatt; Christopher R Barnett; Neville H McClenaghan; Willy J Malaisse
D-glucose metabolism in BRIN-BD11 islet cells.
Biochemical and molecular medicine 1996;57(2):97-105.
1996: Neville H McClenaghan; Christopher R Barnett; Finbarr P M O'Harte; S K Swanston-Flatt; E Ah-Sing; Peter R Flatt
Characteristics of BRIN-BG5 and BRIN-BG7, two novel glucose-responsive insulin-secreting cell lines produced by electrofusion.
The Journal of endocrinology 1996;148(3):409-17.
1996: Neville H McClenaghan; Christopher R Barnett; E Ah-Sing; S K Swanston-Flatt; Peter R Flatt
Secretory properties of clonal insulin-secreting BRIN-BG5 cells, produced by electrofusion.
Biochemical Society transactions 1996;24(1):101S.
1994: Neville H McClenaghan; T W Yoon; Christopher R Barnett; A M Wilson; Yasser H A Abdel-Wahab; S Swanston-Flatt; E Ah-Singh; Peter R Flatt
Effect of glucose and amino acids on insulin-secretion from a novel pancreatic B-cell line produced by electrofusion.
Biochemical Society transactions 1994;22(2):237S.