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Leo McCluskey

Research Profile

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William T Hu; Howard I Hurtig; Jason Karlawish; Max Kuhn; Virginia M-Y Lee; Leo McCluskey; John C Morris; Richard Perrin; Eve Pickering; Leslie M Shaw; Andrew Siderowf; Holly Soares; Frank Swenson; John Q Trojanowski; Vivianna M Van Deerlin; Chengjie Xiong; Steven E Arnold; Yu Chen; Alice Chen-Plotkin; Christopher M Clark; Rebecca Craig-Schapiro; Lauren B Elman; Anne M Fagan; Murray Grossman; David M Holtzman
Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease.
Maria Martinez-Lage; Leo McCluskey; Laura Molina-Porcel; Dana Falcone; Virginia M-Y Lee; Vivianna M Van Deerlin; John Q Trojanowski
TDP-43 pathology in a case of hereditary spastic paraplegia with a NIPA1/SPG6 mutation.
Johannes Brettschneider; Lauren B Elman; Murray Grossman; David J Irwin; Linda K Kwong; Edward B Lee; Virginia M-Y Lee; Leo McCluskey; Laura Molina-Porcel; Mervyn Monteiro; John L Robinson; Nathaniel Safren; Jon B Toledo; Yousuf O Ali; Vivianna M Van Deerlin; John Q Trojanowski
Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion.

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All Publications

2012: William T Hu; Howard I Hurtig; Jason Karlawish; Max Kuhn; Virginia M-Y Lee; Leo McCluskey; John C Morris; Richard Perrin; Eve Pickering; Leslie M Shaw; Andrew Siderowf; Holly Soares; Frank Swenson; John Q Trojanowski; Vivianna M Van Deerlin; Chengjie Xiong; Steven E Arnold; Yu Chen; Alice Chen-Plotkin; Christopher M Clark; Rebecca Craig-Schapiro; Lauren B Elman; Anne M Fagan; Murray Grossman; David M Holtzman
Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease.
Neurology 2012;79(9):897-905.
2012: Maria Martinez-Lage; Leo McCluskey; Laura Molina-Porcel; Dana Falcone; Virginia M-Y Lee; Vivianna M Van Deerlin; John Q Trojanowski
TDP-43 pathology in a case of hereditary spastic paraplegia with a NIPA1/SPG6 mutation.
Acta neuropathologica 2012;124(2):285-91.
2012: Johannes Brettschneider; Lauren B Elman; Murray Grossman; David J Irwin; Linda K Kwong; Edward B Lee; Virginia M-Y Lee; Leo McCluskey; Laura Molina-Porcel; Mervyn Monteiro; John L Robinson; Nathaniel Safren; Jon B Toledo; Yousuf O Ali; Vivianna M Van Deerlin; John Q Trojanowski
Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion.
Acta neuropathologica 2012;123(6):825-39.
2012: Heather E Moss; Lauren Talman; Leo McCluskey; Laura J Balcer; Lauren B Elman; Steven L Galetta; Murray Grossman; Katelin Hoskins; Grant T Liu
Cross-sectional evaluation of clinical neuro-ophthalmic abnormalities in an amyotrophic lateral sclerosis population.
Journal of the neurological sciences 2012;314(1-2):97-101.
2012: Johannes Brettschneider; Lauren B Elman; Felix Geser; Murray Grossman; Virginia M-Y Lee; David J Libon; Leo McCluskey; Jon B Toledo; Sharon X Xie; John Q Trojanowski
Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis.
Acta neuropathologica 2012;123(3):395-407.
2012: Johannes Brettschneider; Lauren B Elman; Virginia M-Y Lee; Leo McCluskey; Jon B Toledo; Vivianna M Van Deerlin; John Q Trojanowski
Microglial activation correlates with disease progression and upper motor neuron clinical symptoms in amyotrophic lateral sclerosis.
PloS one 2012;7(6):e39216.
2011: Sharon X Xie; Vivianna M Van Deerlin; Steven E Arnold; Young Baek; Lauren B Elman; Murray Grossman; Howard I Hurtig; Jason Karlawish; Virginia M-Y Lee; Leo McCluskey; Andrew Siderowf; John Q Trojanowski
Building an integrated neurodegenerative disease database at an academic health center.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2011;7(4):e84-93.
2011: Alice S Chen-Plotkin; William T Hu; Andrew Siderowf; Daniel Weintraub; Rachel Goldmann Gross; Howard I Hurtig; Sharon X Xie; Steven E Arnold; Murray Grossman; Christopher M Clark; Leslie M Shaw; Leo McCluskey; Lauren Elman; Vivianna M Van Deerlin; Virginia M-Y Lee; Holly Soares; John Q Trojanowski
Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease.
Annals of neurology 2011;69(4):655-63.
2011: Felix Geser; Beth Stein; Michael Partain; Lauren B Elman; Leo McCluskey; Sharon X Xie; Vivianna M Van Deerlin; Linda K Kwong; Virginia M-Y Lee; John Q Trojanowski
Motor neuron disease clinically limited to the lower motor neuron is a diffuse TDP-43 proteinopathy.
Acta neuropathologica 2011;121(4):509-17.
2011: Ryan Vass; Emily Ashbridge; Felix Geser; William T Hu; Murray Grossman; Dana Clay-Falcone; Lauren B Elman; Leo McCluskey; Virginia M-Y Lee; Vivianna M Van Deerlin; John Q Trojanowski; Alice S Chen-Plotkin
Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis.
Acta neuropathologica 2011;121(3):373-80.
2011: Zhenming Yu; Yongqing Zhu; Alice S Chen-Plotkin; Dana Clay-Falcone; Leo McCluskey; Lauren B Elman; Robert G Kalb; John Q Trojanowski; Virginia M-Y Lee; Vivianna M Van Deerlin; Aaron D Gitler; Nancy M Bonini
PolyQ repeat expansions in ATXN2 associated with ALS are CAA interrupted repeats.
PloS one 2011;6(3):e17951.
2010: W T Hu; A Chen-Plotkin; Murray Grossman; Steven E Arnold; Christopher M Clark; L M Shaw; Leo McCluskey; Lauren B Elman; Howard I Hurtig; Andrew Siderowf; V M-Y Lee; H Soares; John Q Trojanowski
Novel CSF biomarkers for frontotemporal lobar degenerations.
Neurology 2010;75(23):2079-86.
2010: William T Hu; Alice Chen-Plotkin; Steven E Arnold; Murray Grossman; Christopher M Clark; Leslie M Shaw; Leo McCluskey; Lauren Elman; Jason Karlawish; Howard I Hurtig; Andrew Siderowf; Virginia M-Y Lee; Holly Soares; John Q Trojanowski
Biomarker discovery for Alzheimer's disease, frontotemporal lobar degeneration, and Parkinson's disease.
Acta neuropathologica 2010;120(3):385-99.
2010: Andrew C Elden; Hyung-Jun Kim; Michael P Hart; Alice S Chen-Plotkin; Brian S Johnson; Xiaodong Fang; Maria Armakola; Felix Geser; Robert Greene; Min Min Lu; Arun Padmanabhan; Dana Clay-Falcone; Leo McCluskey; Lauren Elman; Denise Juhr; Peter J Gruber; Udo Rüb; Georg Auburger; John Q Trojanowski; Virginia M-Y Lee; Vivianna M Van Deerlin; Nancy M Bonini; Aaron D Gitler
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.
Nature 2010;466(7310):1069-75.
2010: William T Hu; Alice Chen-Plotkin; Steven E Arnold; Murray Grossman; Christopher M Clark; Leslie M Shaw; Eve Pickering; Max Kuhn; Yu Chen; Leo McCluskey; Lauren Elman; Jason Karlawish; Howard I Hurtig; Andrew Siderowf; Virginia M-Y Lee; Holly Soares; John Q Trojanowski
Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment.
Acta neuropathologica 2010;119(6):669-78.
2010: Sanjeev Chawla; Sumei Wang; Peachie Moore; John H Woo; Lauren B Elman; Leo McCluskey; Elias Melhem; Murray Grossman; harish poptani
Quantitative proton magnetic resonance spectroscopy detects abnormalities in dorsolateral prefrontal cortex and motor cortex of patients with frontotemporal lobar degeneration.
Journal of neurology 2010;257(1):114-21.
2009: Felix Geser; Maria Martinez-Lage; John Robinson; Kunihiro Uryu; Manuela Neumann; Nicholas J Brandmeir; Sharon X Xie; Linda K Kwong; Lauren B Elman; Leo McCluskey; Chris M Clark; Joe Malunda; Bruce L Miller; Earl A Zimmerman; Jiang Qian; Vivianna M Van Deerlin; Murray Grossman; Virginia M-Y Lee; John Q Trojanowski
Clinical and pathological continuum of multisystem TDP-43 proteinopathies.
Archives of neurology 2009;66(2):180-9.
2009: Leo McCluskey; Lauren B Elman; Maria Martinez-Lage; Vivianna M Van Deerlin; Wuxing Yuan; Dana Clay; Andrew Siderowf; John Q Trojanowski
Amyotrophic lateral sclerosis-plus syndrome with TAR DNA-binding protein-43 pathology.
Archives of neurology 2009;66(1):121-4.
2008: Murray Grossman; C Anderson; A Khan; Brian Avants; Lauren B Elman; Leo McCluskey
Impaired action knowledge in amyotrophic lateral sclerosis.
Neurology 2008;71(18):1396-401.
2008: Lionel M Igaz; Linda K Kwong; Yan Xu; Adam C Truax; Kunihiro Uryu; Manuela Neumann; Christopher M Clark; Lauren B Elman; Bruce L Miller; Murray Grossman; Leo McCluskey; John Q Trojanowski; Virginia M-Y Lee
Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
The American journal of pathology 2008;173(1):182-94.
2008: Felix Geser; Nicholas J Brandmeir; Linda K Kwong; Maria Martinez-Lage; Lauren B Elman; Leo McCluskey; Sharon X Xie; Virginia M-Y Lee; John Q Trojanowski
Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis.
Archives of neurology 2008;65(5):636-41.
2008: Vivianna M Van Deerlin; James B Leverenz; Lynn M Bekris; Thomas D Bird; Wuxing Yuan; Lauren B Elman; Dana Clay; Elisabeth McCarty Wood; Alice S Chen-Plotkin; Maria Martinez-Lage; Ellen Steinbart; Leo McCluskey; Murray Grossman; Manuela Neumann; I-Lin Wu; Wei-Shiung Yang; Robert Kalb; Douglas Galasko; Thomas J Montine; John Q Trojanowski; Virginia M-Y Lee; Gerard D Schellenberg; Chang-En Yu
TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis.
Lancet neurology 2008;7(5):409-16.
2008: Lauren B Elman; Leo McCluskey; Murray Grossman
Motor neuron disease and frontotemporal lobar degeneration: a tale of two disorders linked to TDP-43.
Neuro-Signals 2008;16(1):85-90.
2007: Hui Zhang; Brian Avants; Paul A Yushkevich; John H Woo; Sumei Wang; Leo McCluskey; Lauren B Elman; Elias Melhem; James C Gee
High-dimensional spatial normalization of diffusion tensor images improves the detection of white matter differences: an example study using amyotrophic lateral sclerosis.
IEEE transactions on medical imaging 2007;26(11):1585-97.
2007: Murray Grossman; Elisabeth M Wood; Peachie Moore; Manuela Neumann; Linda K Kwong; Mark S Forman; Christopher M Clark; Leo McCluskey; Bruce L Miller; Virginia M-Y Lee; John Q Trojanowski
TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Archives of neurology 2007;64(10):1449-54.
2007: Lauren B Elman; David J Houghton; Tom Li Stephen; Howard I Hurtig; Clyde E Markowitz; Leo McCluskey
Palliative care in amyotrophic lateral sclerosis, Parkinson's disease, and multiple sclerosis.
Journal of palliative medicine 2007;10(2):433-57.
2007: Leo McCluskey
Amyotrophic Lateral Sclerosis: ethical issues from diagnosis to end of life.
NeuroRehabilitation 2007;22(6):463-72.
2007: Merisa Palovcak; James M Mancinelli; Lauren B Elman; Leo McCluskey
Diagnostic and therapeutic methods in the management of dysphagia in the ALS population: issues in efficacy for the out-patient setting.
NeuroRehabilitation 2007;22(6):417-23.
2006: Manuela Neumann; Deepak M Sampathu; Linda K Kwong; Adam C Truax; Matthew Micsenyi; Thomas T Chou; Jennifer Bruce; Theresa Schuck; Murray Grossman; Christopher M Clark; Leo McCluskey; Bruce L Miller; Eliezer Masliah; Ian R A Mackenzie; Howard Feldman; Wolfgang Feiden; Hans A Kretzschmar; John Q Trojanowski; Virginia M-Y Lee
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Science (New York, N.Y.) 2006;314(5796):130-3.
2006: Lauren B Elman; Lisa Stanley; Patricia Gibbons; Leo McCluskey
A cost comparison of hospice care in amyotrophic lateral sclerosis and lung cancer.
The American journal of hospice & palliative care 2006;23(3):212-6.
2006: Sumei Wang; harish poptani; Michel Bilello; X Wu; John H Woo; Lauren B Elman; Leo McCluskey; Jaroslaw Krejza; Elias Melhem
Diffusion tensor imaging in amyotrophic lateral sclerosis: volumetric analysis of the corticospinal tract.
AJNR. American journal of neuroradiology 2006;27(6):1234-8.
2006: Sumei Wang; harish poptani; John H Woo; Lisa M Desiderio; Lauren B Elman; Leo McCluskey; Jaroslaw Krejza; Elias Melhem
Amyotrophic lateral sclerosis: diffusion-tensor and chemical shift MR imaging at 3.0 T.
Radiology 2006;239(3):831-8.
2006: Keith M Robinson; S C Lacey; PK Grugan; Guila Glosser; Murray Grossman; Leo McCluskey
Cognitive functioning in sporadic amyotrophic lateral sclerosis: a six month longitudinal study.
Journal of neurology, neurosurgery, and psychiatry 2006;77(5):668-70.
2006: Leo McCluskey
Presymptomatic Genetic Testing for ALS.
The virtual mentor : VM 2006;8(1):16-9.
2005: Lauren B Elman; Randy M Dubin; Mary Kelley; Leo McCluskey
Management of oropharyngeal and tracheobronchial secretions in patients with neurologic disease.
Journal of palliative medicine 2005;8(6):1150-9.
2005: Lauren B Elman; Andrew Siderowf; Gail Houseman; Mary Kelley; Leo McCluskey
Venous thrombosis in an ALS population over four years.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 2005;6(4):246-9.
2005: Tsao-Wei Liang; Mark S Forman; John E Duda; Leo McCluskey; John Q Trojanowski; Andrew Siderowf
Multiple pathologies in a patient with a progressive neurodegenerative syndrome.
Journal of neurology, neurosurgery, and psychiatry 2005;76(2):252-5.
2004: Leo McCluskey; David Casarett; Andrew Siderowf
Breaking the news: a survey of ALS patients and their caregivers.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 2004;5(3):131-5.
2004: Lauren B Elman; Leo McCluskey
Occupational and sport related traumatic neuropathy.
The neurologist 2004;10(2):82-96.
2004: Leo McCluskey; Gail Houseman
Medicare hospice referral criteria for patients with amyotrophic lateral sclerosis: a need for improvement.
Journal of palliative medicine 2004;7(1):47-53.
2003: Lauren B Elman; Andrew Siderowf; Leo McCluskey
Nocturnal oximetry: utility in the respiratory management of amyotrophic lateral sclerosis.
American journal of physical medicine & rehabilitation / Association of Academic Physiatrists 2003;82(11):866-70.
2002: Susan Gregory; Andrew Siderowf; Ame L Golaszewski; Leo McCluskey
Gastrostomy insertion in ALS patients with low vital capacity: respiratory support and survival.
Neurology 2002;58(3):485-7.
2001: J Varrato; Andrew Siderowf; P Damiano; S Gregory; D Feinberg; Leo McCluskey
Postural change of forced vital capacity predicts some respiratory symptoms in ALS.
Neurology 2001;57(2):357-9.
2001: W Robinson; S L Galetta; Leo McCluskey; M S Forman; L J Balcer
Retinal findings in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (cadasil).
Survey of ophthalmology 2001;45(5):445-8.
2000: Tudor G Jovin; R A Vitti; Leo McCluskey
Evolution of temporal lobe hypoperfusion in transient global amnesia: a serial single photon emission computed tomography study.
Journal of neuroimaging : official journal of the American Society of Neuroimaging 2000;10(4):238-41.
1999: Leo McCluskey; D Feinberg; C Cantor; S Bird
"Pseudo-conduction block" in vasculitic neuropathy.
Muscle & nerve 1999;22(10):1361-6.
1999: Leo McCluskey; S Bird
Conduction block in vasculitic neuropathy.
Muscle & nerve 1999;22(7):968.
1999: Leo McCluskey; D Feinberg; Carol A Dolinskas
Suprascapular neuropathy related to a glenohumeral joint cyst.
Muscle & nerve 1999;22(6):772-7.
1999: Leo McCluskey; L B Webb
Compression and entrapment neuropathies of the lower extremity.
Clinics in podiatric medicine and surgery 1999;16(1):97-125, vii.
1997: Mark M Rich; Shawn J Bird; EC Raps; Leo McCluskey; James Wallace Teener
Direct muscle stimulation in acute quadriplegic myopathy.
Muscle & nerve 1997;20(6):665-73.
1988: J E Mollman; W M Hogan; D J Glover; Leo McCluskey
Unusual presentation of cis-platinum neuropathy.
Neurology 1988;38(3):488-90.