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David McConkey

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TOP 3
Tiewei Cheng; Woonyoung Choi; Colin Dinney; Peter C Black; Beat Roth; David J McConkey
Fibroblast growth factor receptors-1 and -3 play distinct roles in the regulation of bladder cancer growth and metastasis: implications for therapeutic targeting.
Rian J Dickstein; Colin P Dinney; Ashish M Kamat; Barry R Davies; Giovanni Nitti; David J McConkey
Autophagy limits the cytotoxic effects of the AKT inhibitor AZ7328 in human bladder cancer cells.
Heping Liu; David J McConkey; John F Ward; Ti Zhang; Rong Chen; Steven A Curley
Multiple kinase pathways involved in the different de novo sensitivity of pancreatic cancer cell lines to 17-AAG.

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All Publications

2013: Tiewei Cheng; Woonyoung Choi; Colin Dinney; Peter C Black; Beat Roth; David J McConkey
Fibroblast growth factor receptors-1 and -3 play distinct roles in the regulation of bladder cancer growth and metastasis: implications for therapeutic targeting.
PloS one 2013;8(2):e57284.
2012: Rian J Dickstein; Colin P Dinney; Ashish M Kamat; Barry R Davies; Giovanni Nitti; David J McConkey
Autophagy limits the cytotoxic effects of the AKT inhibitor AZ7328 in human bladder cancer cells.
Cancer biology & therapy 2012;13(13):1325-38.
2012: Heping Liu; David J McConkey; John F Ward; Ti Zhang; Rong Chen; Steven A Curley
Multiple kinase pathways involved in the different de novo sensitivity of pancreatic cancer cell lines to 17-AAG.
The Journal of surgical research 2012;176(1):147-53.
2012: Michael P Kim; Craig Logsdon; David J McConkey; Mark J Truty; Huamin Wang; James Abbruzzesse; Woonyoung Choi; Xavier Chopin-Lally; Gary E Gallick; Rosa Hwang; Ya'an Kang; Jason B Fleming
Molecular profiling of direct xenograft tumors established from human pancreatic adenocarcinoma after neoadjuvant therapy.
Annals of surgical oncology 2012;19 Suppl 3():S395-403.
2012: Lauren Marquis; Arlene Siefker-Radtke; Mai Tran; Woonyoung Choi; Colin Dinney; Dennis Huszar; I-Ling Lee; David J McConkey
p63 expression correlates with sensitivity to the Eg5 inhibitor ZD4877 in bladder cancer cells.
Cancer biology & therapy 2012;13(7):477-86.
2012: David J McConkey; Matthew White; Wudan Yan
HDAC inhibitor modulation of proteotoxicity as a therapeutic approach in cancer.
Advances in cancer research 2012;116():131-63.
2012: Woonyoung Choi; Colin Dinney; I-Ling Lee; Lauren Marquis; David J McConkey; Jay B Shah; Yu Shen; Robert S Svatek; Mai Tran; Sijin Wen; Dasom Yu; Liana Adam; Arlene Siefker-Radtke
p63 expression defines a lethal subset of muscle-invasive bladder cancers.
PloS one 2012;7(1):e30206.
2011: Triona Ni Chonghaile; Paul Richardson; Jeremy A Ryan; Stephen E Sallan; Kristopher A Sarosiek; Lewis Silverman; Richard Stone; Yu-Tzu Tai; Anupama Tammareddi; Thanh-Trang Vo; Kenneth C Anderson; Daniel Ruben Carrasco; Daniel J DeAngelo; Jing Deng; Ronny Drapkin; Michelle S Hirsch; Ursula A Matulonis; David J McConkey; Constantine S Mitsiades; Victoria Del Gaizo Moore; Anthony Letai
Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy.
Science (New York, N.Y.) 2011;334(6059):1129-33.
2011: David J McConkey
RAIDDing ER stress for oncolytic viral therapy.
Cancer cell 2011;20(4):416-8.
2011: Filip Janku; David S Hong; David J McConkey; Razelle Kurzrock
Autophagy as a target for anticancer therapy.
Nature reviews. Clinical oncology 2011;8(9):528-39.
2011: Edmund Chiong; I-Ling Lee; Ali Dadbin; Anita L Sabichi; Loleta Harris; Diana Urbauer; David J McConkey; Rian J Dickstein; Tiewei Cheng; H Barton Grossman
Effects of mTOR inhibitor everolimus (RAD001) on bladder cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(9):2863-73.
2011: Jay B Shah; David J McConkey; Colin P N Dinney
New strategies in muscle-invasive bladder cancer: on the road to personalized medicine.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(9):2608-12.
2011: Peter C Black; Gordon A Brown; Colin P Dinney; Wassim Kassouf; Teruo Inamoto; Ameeta Arora; David Gallagher; Mark F Munsell; Menashe Bar-Eli; David J McConkey; Liana Adam
Receptor heterodimerization: a new mechanism for platelet-derived growth factor induced resistance to anti-epidermal growth factor receptor therapy for bladder cancer.
The Journal of urology 2011;185(2):693-700.
2011: Michael P Kim; Scott Kopetz; David J McConkey; Huamin Wang; James L Abbruzzese; Woonyoung Choi; Douglas B Evans; Jason B Fleming; Gary E Gallick
ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma.
PloS one 2011;6(6):e20636.
2010: Mai N Tran; G Goodwin Jinesh; David J McConkey; Ashish M Kamat
Bladder cancer stem cells.
Current stem cell research & therapy 2010;5(4):387-95.
2010: Adam R Metwalli; Sanaz Khanbolooki; Goodwin Jinesh; Debasish Sundi; Jay B Shah; Marissa Shrader; Woonyoung Choi; Laura M Lashinger; Srinivas Chunduru; David J McConkey; Mark McKinlay; Ashish M Kamat
Smac mimetic reverses resistance to TRAIL and chemotherapy in human urothelial cancer cells.
Cancer biology & therapy 2010;10(9):885-92.
2010: Robert S Svatek; Jay B Shah; Jinliang Xing; David Chang; Jie Lin; David J McConkey; Xifeng Wu; Colin P Dinney
A multiplexed, particle-based flow cytometric assay identified plasma matrix metalloproteinase-7 to be associated with cancer-related death among patients with bladder cancer.
Cancer 2010;116(19):4513-9.
2010: David J McConkey; Sangkyou Lee; Woonyoung Choi; Mai Tran; Tadeusz Majewski; Sooyong Lee; Arlene Siefker-Radtke; Colin Dinney; Bogdan Czerniak
Molecular genetics of bladder cancer: Emerging mechanisms of tumor initiation and progression.
Urologic oncology 2010;28(4):429-40.
2010: K Zhu; Kenneth Dunner; David J McConkey
Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells.
Oncogene 2010;29(3):451-62.
2009: David J McConkey; Colin P N Dinney
Urological cancers. Preface.
Cancer metastasis reviews 2009;28(3-4):267.
2009: David J McConkey; Woonyoung Choi; Lauren Marquis; Frances Martin; Michael B Williams; Jay Shah; Robert S Svatek; Aditi Das; Liana Adam; Ashish Kamat; Arlene Siefker-Radtke; Colin P N Dinney
Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer.
Cancer metastasis reviews 2009;28(3-4):335-44.
2009: David J McConkey; Colin P Dinney
The molecular, the bad, and the ugly: preventing bladder cancer via mTOR inhibition.
Cancer prevention research (Philadelphia, Pa.) 2009;2(12):1001-2.
2009: Liana Adam; Meng Zhong; Woonyoung Choi; Wei Qi; Milena S Nicoloso; Ameeta Arora; George A Calin; Hua Wang; Arlene Siefker-Radtke; David J McConkey; Menashe Bar-Eli; Colin P N Dinney
miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(16):5060-72.
2009: Thiruvengadam Arumugam; Vijaya Ramachandran; Keith F Fournier; Huamin Wang; Lauren Marquis; James L Abbruzzese; Gary E Gallick; Craig D Logsdon; David J McConkey; Woonyoung Choi
Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer.
Cancer research 2009;69(14):5820-8.
2009: M B Fisher; X-Q Zhang; David J McConkey; William F Benedict
Measuring soluble forms of extracellular cytokeratin 18 identifies both apoptotic and necrotic mechanisms of cell death produced by adenoviral-mediated interferon alpha: possible use as a surrogate marker.
Cancer gene therapy 2009;16(7):567-72.
2009: Gonzalo Lopez; Juehui Liu; Wenhong Ren; Wei Wei; Suizhao Wang; Guy Lahat; Quan-Sheng Zhu; William G Bornmann; David J McConkey; Raphael E Pollock; Dina lev
Combining PCI-24781, a novel histone deacetylase inhibitor, with chemotherapy for the treatment of soft tissue sarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(10):3472-83.
2009: Keyi Zhu; Waikin Chan; John V Heymach; Miles Wilkinson; David J McConkey
Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression.
Cancer research 2009;69(5):1836-43.
2009: Yasmine Haddad; Woonyoung Choi; David J McConkey
Delta-crystallin enhancer binding factor 1 controls the epithelial to mesenchymal transition phenotype and resistance to the epidermal growth factor receptor inhibitor erlotinib in human head and neck squamous cell carcinoma lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(2):532-42.
2008: Steffan Nawrocki; Jennifer Carew; Kirsteen H Maclean; James F Courage; Peng Huang; Janet A Houghton; John L Cleveland; Francis Giles; David J McConkey
Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA.
Blood 2008;112(7):2917-26.
2008: Kevin B Kim; Omar Eton; Darren W Davis; M L Frazier; David J McConkey; A Hafeez Diwan; Nicholas E Papadopoulos; Agop Bedikian; L H Camacho; M I Ross; J N Cormier; jeffrey gershenwald; J E Lee; P F Mansfield; L A Billings; C S Ng; C Charnsangavej; Menashe Bar-Eli; Marcella M Johnson; A J Murgo; Victor G Prieto
Phase II trial of imatinib mesylate in patients with metastatic melanoma.
British journal of cancer 2008;99(5):734-40.
2008: Wassim Kassouf; Gordon A Brown; Peter C Black; Mark B Fisher; Teruo Inamoto; Tony Luongo; David Gallagher; Menashe Bar-Eli; David J McConkey; Liana Adam; Colin P N Dinney
Is vascular endothelial growth factor modulation a predictor of the therapeutic efficacy of gefitinib for bladder cancer?
The Journal of urology 2008;180(3):1146-53.
2008: David J McConkey; Keyi Zhu
Mechanisms of proteasome inhibitor action and resistance in cancer.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2008;11(4-5):164-79.
2008: David J McConkey
A novel role for a familiar protein in apoptosis induced by proteasome inhibition.
Cancer cell 2008;14(1):1-2.
2008: Peter C Black; Gordon A Brown; Teruo Inamoto; Marissa Shrader; Ameeta Arora; Arlene O Siefker-Radtke; Liana Adam; Dan Theodorescu; Xifeng Wu; Mark F Munsell; Menashe Bar-Eli; David J McConkey; Colin P N Dinney
Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(5):1478-86.
2008: Wassim Kassouf; Peter C Black; Tomasz Tuziak; Jolanta Bondaruk; Sangkyou Lee; Gordon A Brown; Liana Adam; Caimiao Wei; Keith A Baggerly; Menashe Bar-Eli; David J McConkey; Bogdan Czerniak; Colin P N Dinney
Distinctive expression pattern of ErbB family receptors signifies an aggressive variant of bladder cancer.
The Journal of urology 2008;179(1):353-8.
2007: G J Villares; M Zigler; Kelly N Blehm; C Bogdan; David J McConkey; D Colin; Menashe Bar-Eli
Targeting EGFR in bladder cancer.
World journal of urology 2007;25(6):573-9.
2007: Piyush K Agarwal; Peter C Black; David J McConkey; Colin P N Dinney
Emerging drugs for targeted therapy of bladder cancer.
Expert opinion on emerging drugs 2007;12(3):435-48.
2007: Sangkyou Lee; Joon Jeong; Tadeusz Majewski; Steven E Scherer; Mi-Sook Kim; Tomasz Tuziak; Kuang S Tang; Keith A Baggerly; H Barton Grossman; Jain-Hua Zhou; Lanlan Shen; Jolanta Bondaruk; Saira S Ahmed; Susmita Samanta; Philippe E Spiess; Xifeng Wu; Slawomir Filipek; David J McConkey; Menashe Bar-Eli; Jean-Pierre J Issa; William F Benedict; Bogdan Czerniak
Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(34):13732-7.
2007: Claudia P Miller; Kechen Ban; Melanie E Dujka; David J McConkey; Mark F Munsell; Michael Palladino; Joya Chandra
NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells.
Blood 2007;110(1):267-77.
2007: Angela Papageorgiou; Colin P N Dinney; David J McConkey
Interferon-alpha induces TRAIL expression and cell death via an IRF-1-dependent mechanism in human bladder cancer cells.
Cancer biology & therapy 2007;6(6):872-9.
2007: Liana Adam; Peter C Black; Wassim Kassouf; Beryl Eve; David J McConkey; Mark F Munsell; William F Benedict; Colin P N Dinney
Adenoviral mediated interferon-alpha 2b gene therapy suppresses the pro-angiogenic effect of vascular endothelial growth factor in superficial bladder cancer.
The Journal of urology 2007;177(5):1900-6.
2007: Xinqiao Zhang; Z Yang; L Dong; Angela Papageorgiou; David J McConkey; William F Benedict
Adenoviral-mediated interferon alpha overcomes resistance to the interferon protein in various cancer types and has marked bystander effects.
Cancer gene therapy 2007;14(3):241-50.
2007: Marissa Shrader; Maria S Pino; Laura M Lashinger; Menashe Bar-Eli; Liana Adam; Colin P N Dinney; David J McConkey
Gefitinib reverses TRAIL resistance in human bladder cancer cell lines via inhibition of AKT-mediated X-linked inhibitor of apoptosis protein expression.
Cancer research 2007;67(4):1430-5.
2007: David J McConkey
Therapy-induced apoptosis in primary tumors.
Advances in experimental medicine and biology 2007;608():31-51.
2007: Marissa Shrader; Maria S Pino; Gordon Brown; Peter Black; Liana Adam; Menashe Bar-Eli; Colin P N Dinney; David J McConkey
Molecular correlates of gefitinib responsiveness in human bladder cancer cells.
Molecular cancer therapeutics 2007;6(1):277-85.
2006: Angela Papageorgiou; Ashish Kamat; William F Benedict; Colin P N Dinney; David J McConkey
Combination therapy with IFN-alpha plus bortezomib induces apoptosis and inhibits angiogenesis in human bladder cancer cells.
Molecular cancer therapeutics 2006;5(12):3032-41.
2006: Jeffrey Walterscheid; Dat X Nghiem; Nasser Kazimi; Leta K Nutt; David J McConkey; Mary Norval; Stephen Ullrich
Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17420-5.
2006: Sanaz Khanbolooki; Steffan Nawrocki; Thiruvengadam Arumugam; Robert H I Andtbacka; Maria S Pino; Razelle Kurzrock; Craig D Logsdon; James L Abbruzzese; David J McConkey
Nuclear factor-kappaB maintains TRAIL resistance in human pancreatic cancer cells.
Molecular cancer therapeutics 2006;5(9):2251-60.
2006: Steven E Canfield; Keyi Zhu; Simon A Williams; David J McConkey
Bortezomib inhibits docetaxel-induced apoptosis via a p21-dependent mechanism in human prostate cancer cells.
Molecular cancer therapeutics 2006;5(8):2043-50.
2006: Kelly N Blehm; Philippe E Spiess; Jolanta Bondaruk; Melanie E Dujka; Gabriel J Villares; Yi-Jue Zhao; Oliver Bogler; Kenneth Aldape; H Barton Grossman; Liana Adam; David J McConkey; Bogdan Czerniak; Colin P N Dinney; Menashe Bar-Eli
Mutations within the kinase domain and truncations of the epidermal growth factor receptor are rare events in bladder cancer: implications for therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(15):4671-7.
2006: Stacey Ruiz; Yelena Krupnik; Michael Keating; Joya Chandra; Michael Palladino; David J McConkey
The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia.
Molecular cancer therapeutics 2006;5(7):1836-43.
2006: Maria S Pino; Marissa Shrader; Cheryl H Baker; Francesco Cognetti; Henry Q Xiong; James L Abbruzzese; David J McConkey
Transforming growth factor alpha expression drives constitutive epidermal growth factor receptor pathway activation and sensitivity to gefitinib (Iressa) in human pancreatic cancer cell lines.
Cancer research 2006;66(7):3802-12.
2006: Steffan Nawrocki; Jennifer Carew; Maria S Pino; Ralph A Highshaw; Robert H I Andtbacka; Kenneth Dunner; Ashutosh Pal; William G Bornmann; Paul J Chiao; Peng Huang; Henry Xiong; James L Abbruzzese; David J McConkey
Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells.
Cancer research 2006;66(7):3773-81.
2006: Jose G Trevino; Michael J Gray; Steffan Nawrocki; Justin M Summy; Donald P Lesslie; Douglas B Evans; Tomi K Sawyer; William C Shakespeare; Stephanie S Watowich; Paul J Chiao; David J McConkey; Gary E Gallick
Src activation of Stat3 is an independent requirement from NF-kappaB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells.
Angiogenesis 2006;9(2):101-10.
2006: Jennifer Carew; Steffan Nawrocki; Yelena V Krupnik; Kenneth Dunner; David J McConkey; Michael J Keating; Peng Huang
Targeting endoplasmic reticulum protein transport: a novel strategy to kill malignant B cells and overcome fludarabine resistance in CLL.
Blood 2006;107(1):222-31.
2005: Steffan Nawrocki; Jennifer Carew; Maria S Pino; Ralph A Highshaw; Kenneth Dunner; Peng Huang; James L Abbruzzese; David J McConkey
Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis.
Cancer research 2005;65(24):11658-66.
2005: Steffan Nawrocki; Jennifer Carew; Kenneth Dunner; Lawrence Boise; Paul J Chiao; Peng Huang; James L Abbruzzese; David J McConkey
Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells.
Cancer research 2005;65(24):11510-9.
2005: Wassim Kassouf; Colin P N Dinney; Gordon Brown; David J McConkey; Alan J Diehl; Menashe Bar-Eli; Liana Adam
Uncoupling between epidermal growth factor receptor and downstream signals defines resistance to the antiproliferative effect of Gefitinib in bladder cancer cells.
Cancer research 2005;65(22):10524-35.
2005: Maria S Pino; Steffan Nawrocki; Francesco Cognetti; James L Abruzzese; Henry Q Xiong; David J McConkey
Prostaglandin E2 drives cyclooxygenase-2 expression via cyclic AMP response element activation in human pancreatic cancer cells.
Cancer biology & therapy 2005;4(11):1263-9.
2005: Laura M Lashinger; Keyi Zhu; Simon A Williams; Marissa Shrader; Colin P N Dinney; David J McConkey
Bortezomib abolishes tumor necrosis factor-related apoptosis-inducing ligand resistance via a p21-dependent mechanism in human bladder and prostate cancer cells.
Cancer research 2005;65(11):4902-8.
2005: David J McConkey; Steffan Nawrocki; Robert H I Andtbacka
Velcade displays promising activity in primary effusion lymphoma cells.
Cancer biology & therapy 2005;4(4):491-2.
2005: Leta K Nutt; Vladimir Gogvadze; Wanlaya Uthaisang; Banafsheh Mirnikjoo; David J McConkey; Sten Orrenius
Indirect effects of Bax and Bak initiate the mitochondrial alterations that lead to cytochrome c release during arsenic trioxide-induced apoptosis.
Cancer biology & therapy 2005;4(4):459-67.
2005: Darren W Davis; Ryan Takamori; Chandrajit P Raut; Henry Q Xiong; Roy S Herbst; Walter M Stadler; John V Heymach; George D Demetri; Asif Rashid; Yu Shen; Sijin Wen; James L Abbruzzese; David J McConkey
Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 1):678-89.
2004: Angela Papageorgiou; Laura M Lashinger; Randall Millikan; H Barton Grossman; William F Benedict; Colin P N Dinney; David J McConkey
Role of tumor necrosis factor-related apoptosis-inducing ligand in interferon-induced apoptosis in human bladder cancer cells.
Cancer research 2004;64(24):8973-9.
2004: Jennifer Carew; Steffan Nawrocki; Rui-Hua Xu; Kenneth Dunner; David J McConkey; William G Wierda; Michael J Keating; P Huang
Increased mitochondrial biogenesis in primary leukemia cells: the role of endogenous nitric oxide and impact on sensitivity to fludarabine.
Leukemia 2004;18(12):1934-40.
2004: Chandrajit P Raut; Steffan Nawrocki; Laura M Lashinger; Darren W Davis; Sanaz Khanbolooki; Henry Xiong; Lee M Ellis; David J McConkey
Celecoxib inhibits angiogenesis by inducing endothelial cell apoptosis in human pancreatic tumor xenografts.
Cancer biology & therapy 2004;3(12):1217-24.
2004: Henry Q Xiong; Roy Herbst; Silvana C Faria; Catherine Scholz; Darren Davis; Edward F Jackson; Timothy Madden; David J McConkey; Marshall Hicks; Kenneth Hess; Chusilp Charnsangavej; James L Abbruzzese
A phase I surrogate endpoint study of SU6668 in patients with solid tumors.
Investigational new drugs 2004;22(4):459-66.
2004: John V Heymach; Jayesh Desai; Judith Manola; Darren W Davis; David J McConkey; David Harmon; David P Ryan; Glenwood Goss; Travis Quigley; Annick D Van den Abbeele; Stuart G Silverman; Susan Connors; Judah Folkman; Christopher D M Fletcher; George D Demetri
Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(17):5732-40.
2004: William F Benedict; Ziming Tao; Chang-Soo Kim; Xinqiao Zhang; Jain-Hua Zhou; Liana Adam; David J McConkey; Angela Papageorgiou; Mark F Munsell; Jennifer Philopena; Heidrun Engler; William Demers; Daniel Maneval; Colin P N Dinney; Robert J Connor
Intravesical Ad-IFNalpha causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-alpha protein.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(3):525-32.
2004: Ralph A Highshaw; David J McConkey; Colin P N Dinney
Integrating basic science and clinical research in bladder cancer: update from the first bladder Specialized Program of Research Excellence (SPORE).
Current opinion in urology 2004;14(5):295-300.
2004: Colin P N Dinney; David J McConkey; Randall E Millikan; Xifeng Wu; Menashe Bar-Eli; Liana Adam; Ashish M Kamat; Arlene Siefker-Radtke; Tomasz Tuziak; Anita L Sabichi; H Barton Grossman; William F Benedict; Bogdan Czerniak
Focus on bladder cancer.
Cancer cell 2004;6(2):111-6.
2004: Darren W Davis; Keiji Inoue; Colin P N Dinney; Daniel J Hicklin; James L Abbruzzese; David J McConkey
Regional effects of an antivascular endothelial growth factor receptor monoclonal antibody on receptor phosphorylation and apoptosis in human 253J B-V bladder cancer xenografts.
Cancer research 2004;64(13):4601-10.
2004: Chandrajit P Raut; Ryan Takamori; Darren W Davis; Bridget Sweeney-Gotsch; Michael S O'Reilly; David J McConkey
Direct effects of recombinant human endostatin on tumor cell IL-8 production are associated with increased endothelial cell apoptosis in an orthotopic model of human pancreatic cancer.
Cancer biology & therapy 2004;3(7):679-87.
2004: Jorge Cortes; Deborah Thomas; Charles Koller; Francis Giles; Elihu Estey; Stefan Faderl; Guillermo Garcia-Manero; David J McConkey; Stacey Ruiz; Gira Patel; Roberto Guerciolini; John Wright; Andrew Lamb
Phase I study of bortezomib in refractory or relapsed acute leukemias.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(10):3371-6.
2004: Bei Zheng; Georgios V Georgakis; Yang Li; Alok C Bharti; David J McConkey; Bharat B Aggarwal; Anas Younes
Induction of cell cycle arrest and apoptosis by the proteasome inhibitor PS-341 in Hodgkin disease cell lines is independent of inhibitor of nuclear factor-kappaB mutations or activation of the CD30, CD40, and RANK receptors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(9):3207-15.
2004: Simona M Pino; Henry Q Xiong; David J McConkey; James L Abbruzzese
Novel therapies for pancreatic adenocarcinoma.
Current oncology reports 2004;6(3):199-206.
2004: Simona M Pino; Henry Q Xiong; David J McConkey; James L Abbruzzese
Novel therapies for pancreatic adenocarcinoma.
Current gastroenterology reports 2004;6(2):119-25.
2004: Ashish M Kamat; Takashi Karashima; Darren W Davis; Laura M Lashinger; Menashe Bar-Eli; Randall Millikan; Yu Shen; Colin P N Dinney; David J McConkey
The proteasome inhibitor bortezomib synergizes with gemcitabine to block the growth of human 253JB-V bladder tumors in vivo.
Molecular cancer therapeutics 2004;3(3):279-90.
2004: David J McConkey; Leta K Nutt
Measurement of changes in intracellular calcium during apoptosis.
Methods in molecular biology (Clifton, N.J.) 2004;282():117-30.
2004: Steffan Nawrocki; Bridget Sweeney-Gotsch; Ryan Takamori; David J McConkey
The proteasome inhibitor bortezomib enhances the activity of docetaxel in orthotopic human pancreatic tumor xenografts.
Molecular cancer therapeutics 2004;3(1):59-70.
2004: Darren W Davis; Yu Shen; Nizar A Mullani; Sijin Wen; Roy S Herbst; Michael O'Reilly; James L Abbruzzese; David J McConkey
Quantitative analysis of biomarkers defines an optimal biological dose for recombinant human endostatin in primary human tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(1 Pt 1):33-42.
2003: Simon A Williams; David J McConkey
The proteasome inhibitor bortezomib stabilizes a novel active form of p53 in human LNCaP-Pro5 prostate cancer cells.
Cancer research 2003;63(21):7338-44.
2003: Jessica C Pahler; Stacey Ruiz; Irina Niemer; Leslie R Calvert; Michael Andreeff; Michael Keating; Stefan Faderl; David J McConkey
Effects of the proteasome inhibitor, bortezomib, on apoptosis in isolated lymphocytes obtained from patients with chronic lymphocytic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(12):4570-7.
2003: Simon Williams; Curtis A Pettaway; Rendu Song; Christos N Papandreou; Christopher Logothetis; David J McConkey
Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumor xenografts.
Molecular cancer therapeutics 2003;2(9):835-43.
2003: Badar M Mian; Colin P N Dinney; Carlos Bermejo; Paul Sweeney; Carmen Tellez; X D Yang; Jean M Gudas; David J McConkey; Menashe Bar-Eli
Fully human anti-interleukin 8 antibody inhibits tumor growth in orthotopic bladder cancer xenografts via down-regulation of matrix metalloproteases and nuclear factor-kappaB.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(8):3167-75.
2003: Takashi Karashima; Paul Sweeney; Ashish Kamat; Suyun Huang; Sun J Kim; Menashe Bar-Eli; David J McConkey; Colin P N Dinney
Nuclear factor-kappaB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(7):2786-97.
2003: Peiying Yang; Peter Collin; Timothy Madden; Diana Chan; Bridget Sweeney-Gotsch; David J McConkey; Robert A Newman
Inhibition of proliferation of PC3 cells by the branched-chain fatty acid, 12-methyltetradecanoic acid, is associated with inhibition of 5-lipoxygenase.
The Prostate 2003;55(4):281-91.
2003: Darren W Davis; David J McConkey; Wei Zhang; Roy S Herbst
Antiangiogenic tumor therapy.
BioTechniques 2003;34(5):1048-50, 1052, 1054 passim.
2003: Darren W Davis; Thomas Buchholz; Kenneth R Hess; Aysegul A Sahin; Vicente Valero; David J McConkey
Automated quantification of apoptosis after neoadjuvant chemotherapy for breast cancer: early assessment predicts clinical response.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(3):955-60.
2003: Xinqiao Zhang; Asha S Multani; Jain-Hua Zhou; Jerry W Shay; David J McConkey; Li Dong; Chang-Soo Kim; Charles J Rosser; Sen Pathak; William F Benedict
Adenoviral-mediated retinoblastoma 94 produces rapid telomere erosion, chromosomal crisis, and caspase-dependent apoptosis in bladder cancer and immortalized human urothelial cells but not in normal urothelial cells.
Cancer research 2003;63(4):760-5.
2003: Thomas Buchholz; Darren W Davis; David J McConkey; W Fraser Symmans; Vicente Valero; Anuja Jhingran; Susan L Tucker; Lajos Pusztai; Massimo Cristofanilli; Francisco J Esteva; Gabriel N Hortobagyi; Aysegul A Sahin
Chemotherapy-induced apoptosis and Bcl-2 levels correlate with breast cancer response to chemotherapy.
Cancer journal (Sudbury, Mass.) 2003;9(1):33-41.
2002: Xiaobo X Cao; Imran Mohuiddin; Sunil Chada; Abner M Mhashilkar; Mustafa K Ozvaran; David J McConkey; Steven D Miller; Jonathan C Daniel; W Roy Smythe
Adenoviral transfer of mda-7 leads to BAX up-regulation and apoptosis in mesothelioma cells, and is abrogated by over-expression of BCL-XL.
Molecular medicine (Cambridge, Mass.) 2002;8(12):869-76.
2002: Steffan Nawrocki; Christiane J Bruns; Matthew T Harbison; Richard J Bold; Bridget Sweeney Gotsch; James L Abbruzzese; Peter Elliott; Julian Adams; David J McConkey
Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts.
Molecular cancer therapeutics 2002;1(14):1243-53.
2002: T Christopher Windham; Nila U Parikh; Doris R Siwak; Justin M Summy; David J McConkey; Alan J Kraker; Gary E Gallick
Src activation regulates anoikis in human colon tumor cell lines.
Oncogene 2002;21(51):7797-807.
2002: Victor M Bondar; Bridget Sweeney-Gotsch; Michael Andreeff; Gordon B Mills; David J McConkey
Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo.
Molecular cancer therapeutics 2002;1(12):989-97.
2002: Roy S Herbst; Nizar A Mullani; Darren W Davis; Kenneth R Hess; David J McConkey; Chusilp Charnsangavej; Michael S O'Reilly; Hyung Woo Kim; Cheryl Baker; Jennifer Roach; Lee M Ellis; Asif Rashid; James Pluda; Corazon D Bucana; Timothy L Madden; Hai T Tran; James L Abbruzzese
Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(18):3804-14.
2002: Roy S Herbst; Kenneth R Hess; Hai T Tran; Jennifer E Tseng; Nizar A Mullani; Chusilp Charnsangavej; Timothy Madden; Darren W Davis; David J McConkey; Michael S O'Reilly; Lee M Ellis; James Pluda; Waun Ki Hong; James L Abbruzzese
Phase I study of recombinant human endostatin in patients with advanced solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(18):3792-803.
2002: Zijian Guo; Gavin Clydesdale; Jinke Cheng; Kihwan Kim; Lin Gan; David J McConkey; Stephen Ullrich; Yuan Zhuang; Bing Su
Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction.
Molecular and cellular biology 2002;22(16):5761-8.
2002: Leta K Nutt; Joya Chandra; Abujiang Pataer; Bingliang Fang; Jack A Roth; Stephen G Swisher; Roger G O'Neil; David J McConkey
Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis.
The Journal of biological chemistry 2002;277(23):20301-8.
2002: A B Santamaria; D W Davis; Dat X Nghiem; David J McConkey; Stephen Ullrich; M Kapoor; G Lozano; Honnavara N Ananthaswamy
p53 and Fas ligand are required for psoralen and UVA-induced apoptosis in mouse epidermal cells.
Cell death and differentiation 2002;9(5):549-60.
2002: Victor M Bondar; David J McConkey
Anoikis is regulated by BCL-2-independent pathways in human prostate carcinoma cells.
The Prostate 2002;51(1):42-9.
2002: Leta K Nutt; Abujiang Pataer; Jessica Pahler; Bingliang Fang; Jack Roth; David J McConkey; Stephen G Swisher
Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores.
The Journal of biological chemistry 2002;277(11):9219-25.
2002: Paula M Termuhlen; Bridget Sweeney-Gotsch; Russell S Berman; Lee M Ellis; Corazon D Bucana; Yu Shen; Karen R Cleary; David J McConkey
Increased apoptosis in metastatic human colonic adenocarcinomas.
Cancer biology & therapy 2002;1(1):58-63.
2001: Xiaobo X Cao; Imran Mohuiddin; Ferrah Ece; David J McConkey; W Roy Smythe
Histone deacetylase inhibitor downregulation of bcl-xl gene expression leads to apoptotic cell death in mesothelioma.
American journal of respiratory cell and molecular biology 2001;25(5):562-8.
2001: Carmen C Solorzano; Young D Jung; Corazon D Bucana; David J McConkey; Gary E Gallick; G McMahon; Lee M Ellis
In vivo intracellular signaling as a marker of antiangiogenic activity.
Cancer research 2001;61(19):7048-51.
2001: Joel W Slaton; Takashi Karashima; Paul Perrotte; Keji Inoue; Sun J Kim; Jonathan I Izawa; Daniel Kedar; David J McConkey; Randall Millikan; Paul Sweeney; Chiaki Yoshikawa; Taro Shuin; Colin P N Dinney
Treatment with low-dose interferon-alpha restores the balance between matrix metalloproteinase-9 and E-cadherin expression in human transitional cell carcinoma of the bladder.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(9):2840-53.
2001: Okot Nyormoi; Zhengxin Wang; Dao Doan; Maribelis Ruiz; David J McConkey; Menashe Bar-Eli
Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells.
Molecular and cellular biology 2001;21(15):4856-67.
2001: RM Shaheen; WW Tseng; Darren W Davis; Wenbiao Liu; Niels Reinmuth; R Vellagas; A A Wieczorek; Y Ogura; David J McConkey; KE Drazan; Corazon D Bucana; G McMahon; Lee M Ellis
Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms.
Cancer research 2001;61(4):1464-8.
2001: David J McConkey; Leta K Nutt
Calcium flux measurements in apoptosis.
Methods in cell biology 2001;66():229-46.
2000: Keji Inoue; Joel W Slaton; Paul Perrotte; Darren W Davis; Christiane J Bruns; Daniel J Hicklin; David J McConkey; Paul Sweeney; Robert Radinsky; Colin P N Dinney
Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(12):4874-84.
2000: S Yano; H Shinohara; Roy S Herbst; H Kuniyasu; Corazon D Bucana; Lee M Ellis; Darren W Davis; David J McConkey; Isaiah J Fidler
Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis.
Cancer research 2000;60(17):4959-67.
2000: Christiane J Bruns; Wenbiao Liu; Darren W Davis; RM Shaheen; David J McConkey; M R Wilson; Corazon D Bucana; Daniel J Hicklin; Lee M Ellis
Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases.
Cancer 2000;89(3):488-99.
2000: David J McConkey; Y Lin; Leta K Nutt; H Z Ozel; Robert A Newman
Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells.
Cancer research 2000;60(14):3807-12.
2000: Asha S Multani; M Ozen; S Narayan; V Kumar; J Chandra; David J McConkey; Robert A Newman; Sen Pathak
Caspase-dependent apoptosis induced by telomere cleavage and TRF2 loss.
Neoplasia (New York, N.Y.) 2000;2(4):339-45.
2000: Keji Inoue; Joel W Slaton; Darren W Davis; Daniel J Hicklin; David J McConkey; Takashi Karashima; Robert Radinsky; Colin P N Dinney
Treatment of human metastatic transitional cell carcinoma of the bladder in a murine model with the anti-vascular endothelial growth factor receptor monoclonal antibody DC101 and paclitaxel.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(7):2635-43.
2000: Didier Jean; Carmen Tellez; Suyun Huang; Darren W Davis; Christiane J Bruns; David J McConkey; S H Hinrichs; Menashe Bar-Eli
Inhibition of tumor growth and metastasis of human melanoma by intracellular anti-ATF-1 single chain Fv fragment.
Oncogene 2000;19(22):2721-30.
2000: Christiane J Bruns; Matthew T Harbison; Darren W Davis; Charles Portera; Rachel Tsan; David J McConkey; Douglas B Evans; James L Abbruzzese; Daniel J Hicklin; Robert Radinsky
Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):1936-48.
2000: Christiane J Bruns; H Shinohara; Matthew T Harbison; Darren W Davis; Gina M Nelkin; Jerald J Killion; David J McConkey; Zhongyun Dong; Isaiah J Fidler
Therapy of human pancreatic carcinoma implants by irinotecan and the oral immunomodulator JBT 3002 is associated with enhanced expression of inducible nitric oxide synthase in tumor-infiltrating macrophages.
Cancer research 2000;60(1):2-7.
1999: RM Shaheen; Darren W Davis; Wenbiao Liu; BK Zebrowski; M R Wilson; Corazon D Bucana; David J McConkey; G McMahon; Lee M Ellis
Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis.
Cancer research 1999;59(21):5412-6.
1999: Michael A Davies; Dimpy Koul; H Dhesi; R Berman; Timothy J McDonnell; David J McConkey; W K Alfred Yung; PA Steck
Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN.
Cancer research 1999;59(11):2551-6.
1999: Richard J Bold; K R Hess; A Scott Pearson; Ana M Grau; Frank A Sinicrope; M Jennings; David J McConkey; Corazon D Bucana; Karen R Cleary; P A Hallin; Paul J Chiao; James L Abbruzzese; Douglas B Evans
Prognostic factors in resectable pancreatic cancer: p53 and bcl-2.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 1999;3(3):263-77.
1999: David J McConkey; Joya Chandra
Protease activation and glucocorticoid-induced apoptosis in chronic lymphocytic leukemia.
Leukemia & lymphoma 1999;33(5-6):421-31.
1999: Richard J Bold; J Chandra; David J McConkey
Gemcitabine-induced programmed cell death (apoptosis) of human pancreatic carcinoma is determined by Bcl-2 content.
Annals of surgical oncology 1999;6(3):279-85.
1999: C Diaz; A T Lee; David J McConkey; Alan J Schroit
Phosphatidylserine externalization during differentiation-triggered apoptosis of erythroleukemic cells.
Cell death and differentiation 1999;6(3):218-26.
1998: Michael Bouvet; Richard J Bold; J Lee; Douglas B Evans; James L Abbruzzese; Paul J Chiao; David J McConkey; J Chandra; Sunil Chada; Bingliang Fang; J A Roth
Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments].
Annals of surgical oncology 1998;5(8):681-8.
1998: Joya Chandra; I Niemer; J Gilbreath; Kay-Oliver Kliche; Michael Andreeff; Emil J Freireich; Michael Keating; David J McConkey
Proteasome inhibitors induce apoptosis in glucocorticoid-resistant chronic lymphocytic leukemic lymphocytes.
Blood 1998;92(11):4220-9.
1998: Didier Jean; Matthew T Harbison; David J McConkey; Z Ronai; Menashe Bar-Eli
CREB and its associated proteins act as survival factors for human melanoma cells.
The Journal of biological chemistry 1998;273(38):24884-90.
1998: David Voehringer; David J McConkey; Timothy J McDonnell; Shawn Brisbay; Raymond E Meyn
Bcl-2 expression causes redistribution of glutathione to the nucleus.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):2956-60.
1997: Richard J Bold; Paula M Termuhlen; David J McConkey
Apoptosis, cancer and cancer therapy.
Surgical oncology 1997;6(3):133-42.
1997: Joya Chandra; J Gilbreath; Emil J Freireich; Kay-Oliver Kliche; Michael Andreeff; Michael Keating; David J McConkey
Protease activation is required for glucocorticoid-induced apoptosis in chronic lymphocytic leukemic lymphocytes.
Blood 1997;90(9):3673-81.
1997: N Mirkovic; David Voehringer; Michael D Story; David J McConkey; Timothy J McDonnell; Raymond E Meyn
Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols.
Oncogene 1997;15(12):1461-70.
1997: Keping Xie; Yunfei Wang; Suyun Huang; Lei Xu; Diane R Bielenberg; Thomas R Salas; David J McConkey; Wei Jiang; Isaiah J Fidler
Nitric oxide-mediated apoptosis of K-1735 melanoma cells is associated with downregulation of Bcl-2.
Oncogene 1997;15(7):771-9.
1996: David J McConkey; G Greene; Curtis A Pettaway
Apoptosis resistance increases with metastatic potential in cells of the human LNCaP prostate carcinoma line.
Cancer research 1996;56(24):5594-9.
1996: Suyun Huang; MR Luca; M Gutman; David J McConkey; K E Langley; S D Lyman; Menashe Bar-Eli
Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential.
Oncogene 1996;13(11):2339-47.
1996: David J McConkey; D Goodrich; Corazon D Bucana; Jim Klostergaard
The human retinoblastoma gene product suppresses ceramide-induced apoptosis in human bladder tumor cells.
Oncogene 1996;13(8):1693-700.
1996: Keping Xie; Suyun Huang; Y Wang; P J Beltran; SH Juang; Zhongyun Dong; J C Reed; Timothy J McDonnell; David J McConkey; Isaiah J Fidler
Bcl-2 protects cells from cytokine-induced nitric-oxide-dependent apoptosis.
Cancer immunology, immunotherapy : CII 1996;43(2):109-15.
1996: David J McConkey
Calcium-dependent, interleukin 1-converting enzyme inhibitor-insensitive degradation of lamin B1 and DNA fragmentation in isolated thymocyte nuclei.
The Journal of biological chemistry 1996;271(37):22398-406.
1996: M C Marin; A Fernandez; R J Bick; Shawn Brisbay; L Maximilian Buja; M Snuggs; David J McConkey; Andrew C von Eschenbach; M J Keating; Timothy J McDonnell
Apoptosis suppression by bcl-2 is correlated with the regulation of nuclear and cytosolic Ca2+.
Oncogene 1996;12(11):2259-66.
1996: David J McConkey; S Orrenius
The role of calcium in the regulation of apoptosis.
Journal of leukocyte biology 1996;59(6):775-83.
1996: A P Warren; K Patel; David J McConkey; R Palacios
CD98: a type II transmembrane glycoprotein expressed from the beginning of primitive and definitive hematopoiesis may play a critical role in the development of hematopoietic cells.
Blood 1996;87(9):3676-87.
1996: David J McConkey; Joya Chandra; S Wright; William Plunkett; Timothy J McDonnell; J C Reed; Michael Keating
Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(7):2624-30.
1996: David J McConkey
The role of calcium in the regulation of apoptosis.
Scanning microscopy 1996;10(3):777-93; discussion 793-4.
1995: A Fernandez; Jeff Kiefer; L Fosdick; David J McConkey
Oxygen radical production and thiol depletion are required for Ca(2+)-mediated endogenous endonuclease activation in apoptotic thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(11):5133-9.
1995: Jeff Kiefer; S Okret; M Jondal; David J McConkey
Functional glucocorticoid receptor expression is required for cAMP-mediated apoptosis in a human leukemic T cell line.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4525-8.
1995: David J McConkey; A Fernandez; J Trent; Honnavara N Ananthaswamy
Oncogene regulation of endonuclease activation in apoptosis.
Cancer letters 1995;94(1):9-16.
1995: N Neamati; A Fernandez; S Wright; Jeff Kiefer; David J McConkey
Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(8):3788-95.
1995: A Fernandez; L J Fosdick; M C Marin; C Diaz; Timothy J McDonnell; Honnavara N Ananthaswamy; David J McConkey
Differential regulation of endogenous endonuclease activation in isolated murine fibroblast nuclei by ras and bcl-2.
Oncogene 1995;10(4):769-74.
1994: David J McConkey; L Fosdick; Luciano D'Adamio; M Jondal; S Orrenius
Co-receptor (CD4/CD8) engagement enhances CD3-induced apoptosis in thymocytes. Implications for negative selection.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(6):2436-43.
1993: P Moingeon; H R Rodewald; David J McConkey; A Mildonian; K Awad; Ellis L Reinherz
Generation of natural killer cells from both Fc gamma RII/III+ and Fc gamma RII/III- murine fetal liver progenitors.
Blood 1993;82(5):1453-62.
1993: Rebecca E Hussey; Linda K Clayton; A Diener; David J McConkey; F D Howard; H R Rodewald; Luciano D'Adamio; F Dallenbach; H Stein; E V Schmidt
Overexpression of CD3 eta during thymic development does not alter the negative selection process.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(4):1183-94.
1992: F D Howard; P Moingeon; U Moebius; David J McConkey; B Yandava; T E Gennert; Ellis L Reinherz
The CD3 zeta cytoplasmic domain mediates CD2-induced T cell activation.
The Journal of experimental medicine 1992;176(1):139-45.
1992: S Koyasu; David J McConkey; Linda K Clayton; S Abraham; B Yandava; T Katagiri; P Moingeon; T Yamamoto; Ellis L Reinherz
Phosphorylation of multiple CD3 zeta tyrosine residues leads to formation of pp21 in vitro and in vivo. Structural changes upon T cell receptor stimulation.
The Journal of biological chemistry 1992;267(5):3375-81.
1992: P Moingeon; J L Lucich; David J McConkey; F Letourneur; B Malissen; JP Kochan; Hsiu-Ching Chang; H R Rodewald; Ellis L Reinherz
CD3 zeta dependence of the CD2 pathway of activation in T lymphocytes and natural killer cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1492-6.
1991: A Bauer; David J McConkey; F D Howard; Linda K Clayton; D Novick; S Koyasu; Ellis L Reinherz
Differential signal transduction via T-cell receptor CD3 zeta 2, CD3 zeta-eta, and CD3 eta 2 isoforms.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3842-6.

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