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David McConkey

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
24
Dinney, Colin
22
Davis, Darren
19
Bar-Eli, Menashe
18
Abbruzzese, James
13
Nawrocki, Steffan
11
Adam, Liana
9
Benedict, William
9
Bucana, Corazon
9
Ellis, Lee
7
Chandra, Joya
7
McDonnell, Timothy
7
Nutt, Leta
7
Pino, Maria
6
Carew, Jennifer
6
Xiong, Henry

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Publications

TOP 3
Adam Liana; Zhong Meng; Choi Woonyoung; Qi Wei; Nicoloso Milena; Arora Ameeta; Calin George; Wang Hua; Siefker-Radtke Arlene; McConkey David; Bar-Eli Menashe; Dinney Colin
miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy.
Arumugam Thiruvengadam; Ramachandran Vijaya; Fournier Keith F; Wang Huamin; Marquis Lauren; Abbruzzese James L; Gallick Gary E; Logsdon Craig D; McConkey David J; Choi Woonyoung
Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer.
Fisher M B; Zhang X-Q; McConkey D J; Benedict W F
Measuring soluble forms of extracellular cytokeratin 18 identifies both apoptotic and necrotic mechanisms of cell death produced by adenoviral-mediated interferon alpha: possible use as a surrogate marker.

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All Publications

2009: Adam Liana; Zhong Meng; Choi Woonyoung; Qi Wei; Nicoloso Milena; Arora Ameeta; Calin George; Wang Hua; Siefker-Radtke Arlene; McConkey David; Bar-Eli Menashe; Dinney Colin
miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(16):5060-72.
2009: Arumugam Thiruvengadam; Ramachandran Vijaya; Fournier Keith F; Wang Huamin; Marquis Lauren; Abbruzzese James L; Gallick Gary E; Logsdon Craig D; McConkey David J; Choi Woonyoung
Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer.
Cancer research 2009;69(14):5820-8.
2009: Fisher M B; Zhang X-Q; McConkey D J; Benedict W F
Measuring soluble forms of extracellular cytokeratin 18 identifies both apoptotic and necrotic mechanisms of cell death produced by adenoviral-mediated interferon alpha: possible use as a surrogate marker.
Cancer gene therapy 2009;16(7):567-72.
2009: Lopez Gonzalo; Liu Juehui; Ren Wenhong; Wei Wei; Wang Suizhao; Lahat Guy; Zhu Quan-Sheng; Bornmann William G; McConkey David J; Pollock Raphael E; Lev Dina C
Combining PCI-24781, a novel histone deacetylase inhibitor, with chemotherapy for the treatment of soft tissue sarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(10):3472-83.
2009: Zhu Keyi; Chan Waikin; Heymach John; Wilkinson Miles; McConkey David J
Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression.
Cancer research 2009;69(5):1836-43.
2009: Haddad Yasmine; Choi Woonyoung; McConkey David J
Delta-crystallin enhancer binding factor 1 controls the epithelial to mesenchymal transition phenotype and resistance to the epidermal growth factor receptor inhibitor erlotinib in human head and neck squamous cell carcinoma lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(2):532-42.
2008: Nawrocki Steffan T; Carew Jennifer S; Maclean Kirsteen H; Courage James F; Huang Peng; Houghton Janet A; Cleveland John L; Giles Francis J; McConkey David J
Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA.
Blood 2008;112(7):2917-26.
2008: Kim K B; Eton O; Davis D W; Frazier M L; McConkey D J; Diwan A H; Papadopoulos N E; Bedikian A Y; Camacho L H; Ross M I; Cormier J N; Gershenwald J E; Lee J E; Mansfield P F; Billings L A; Ng C S; Charnsangavej C; Bar-Eli M; Johnson M M; Murgo A J; Prieto V G
Phase II trial of imatinib mesylate in patients with metastatic melanoma.
British journal of cancer 2008;99(5):734-40.
2008: Kassouf Wassim; Brown Gordon A; Black Peter C; Fisher Mark B; Inamoto Teruo; Luongo Tony; Gallagher David; Bar-Eli Menashe; McConkey David J; Adam Liana; Dinney Colin P N
Is vascular endothelial growth factor modulation a predictor of the therapeutic efficacy of gefitinib for bladder cancer?
The Journal of urology 2008;180(3):1146-53.
2008: McConkey David J; Zhu Keyi
Mechanisms of proteasome inhibitor action and resistance in cancer.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2008;11(4-5):164-79.
2008: McConkey David J
A novel role for a familiar protein in apoptosis induced by proteasome inhibition.
Cancer cell 2008;14(1):1-2.
2008: Black Peter C; Brown Gordon A; Inamoto Teruo; Shrader Marissa; Arora Ameeta; Siefker-Radtke Arlene O; Adam Liana; Theodorescu Dan; Wu Xifeng; Munsell Mark F; Bar-Eli Menashe; McConkey David J; Dinney Colin P N
Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(5):1478-86.
2008: Kassouf Wassim; Black Peter C; Tuziak Tomasz; Bondaruk Jolanta; Lee Sangkyou; Brown Gordon A; Adam Liana; Wei Caimiao; Baggerly Keith; Bar-Eli Menashe; McConkey David; Czerniak Bogdan; Dinney Colin P
Distinctive expression pattern of ErbB family receptors signifies an aggressive variant of bladder cancer.
The Journal of urology 2008;179(1):353-8.
2007: Villares G J; Zigler M; Blehm K; Bogdan C; McConkey D; Colin D; Bar-Eli Menashe
Targeting EGFR in bladder cancer.
World journal of urology 2007;25(6):573-9.
2007: Agarwal Piyush K; Black Peter C; McConkey David J; Dinney Colin P N
Emerging drugs for targeted therapy of bladder cancer.
Expert opinion on emerging drugs 2007;12(3):435-48.
2007: Lee Sangkyou; Jeong Joon; Majewski Tadeusz; Scherer Steven E; Kim Mi-Sook; Tuziak Tomasz; Tang Kuang S; Baggerly Keith; Grossman Herbert Barton; Zhou Jain-Hua; Shen Lanlan; Bondaruk Jolanta; Ahmed Saira S; Samanta Susmita; Spiess Philippe; Wu Xifeng; Filipek Slawomir; McConkey David; Bar-Eli Menashe; Issa Jean-Pierre; Benedict William F; Czerniak Bogdan
Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(34):13732-7.
2007: Miller Claudia P; Ban Kechen; Dujka Melanie E; McConkey David J; Munsell Mark; Palladino Michael; Chandra Joya
NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells.
Blood 2007;110(1):267-77.
2007: Papageorgiou Angela; Dinney Colin P N; McConkey David J
Interferon-alpha induces TRAIL expression and cell death via an IRF-1-dependent mechanism in human bladder cancer cells.
Cancer biology & therapy 2007;6(6):872-9.
2007: Adam Liana; Black Peter C; Kassouf Wassim; Eve Beryl; McConkey David; Munsell Mark F; Benedict William F; Dinney Colin P N
Adenoviral mediated interferon-alpha 2b gene therapy suppresses the pro-angiogenic effect of vascular endothelial growth factor in superficial bladder cancer.
The Journal of urology 2007;177(5):1900-6.
2007: Zhang X; Yang Z; Dong L; Papageorgiou A; McConkey D J; Benedict W F
Adenoviral-mediated interferon alpha overcomes resistance to the interferon protein in various cancer types and has marked bystander effects.
Cancer gene therapy 2007;14(3):241-50.
2007: Shrader Marissa; Pino Maria Simona; Lashinger Laura; Bar-Eli Menashe; Adam Liana; Dinney Colin P N; McConkey David J
Gefitinib reverses TRAIL resistance in human bladder cancer cell lines via inhibition of AKT-mediated X-linked inhibitor of apoptosis protein expression.
Cancer research 2007;67(4):1430-5.
2007: Shrader Marissa; Pino Maria Simona; Brown Gordon; Black Peter; Adam Liana; Bar-Eli Menahse; Dinney Colin P N; McConkey David J
Molecular correlates of gefitinib responsiveness in human bladder cancer cells.
Molecular cancer therapeutics 2007;6(1):277-85.
2007: McConkey David J
Therapy-induced apoptosis in primary tumors.
Advances in experimental medicine and biology 2007;608():31-51.
2006: Papageorgiou Angela; Kamat Ashish; Benedict William F; Dinney Colin; McConkey David J
Combination therapy with IFN-alpha plus bortezomib induces apoptosis and inhibits angiogenesis in human bladder cancer cells.
Molecular cancer therapeutics 2006;5(12):3032-41.
2006: Walterscheid Jeffrey P; Nghiem Dat X; Kazimi Nasser; Nutt Leta K; McConkey David J; Norval Mary; Ullrich Stephen E
Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17420-5.
2006: Khanbolooki Sanaz; Nawrocki Steffan T; Arumugam Thiruvengadam; Andtbacka Robert; Pino Maria S; Kurzrock Razelle; Logsdon Craig D; Abbruzzese James L; McConkey David J
Nuclear factor-kappaB maintains TRAIL resistance in human pancreatic cancer cells.
Molecular cancer therapeutics 2006;5(9):2251-60.
2006: Canfield Steven E; Zhu Keyi; Williams Simon A; McConkey David J
Bortezomib inhibits docetaxel-induced apoptosis via a p21-dependent mechanism in human prostate cancer cells.
Molecular cancer therapeutics 2006;5(8):2043-50.
2006: Blehm Kelly N; Spiess Philippe E; Bondaruk Jolanta E; Dujka Melanie E; Villares Gabriel J; Zhao Yi-Jue; Bogler Oliver; Aldape Kenneth D; Grossman H Barton; Adam Liana; McConkey David J; Czerniak Bogdan A; Dinney Colin P; Bar-Eli Menashe
Mutations within the kinase domain and truncations of the epidermal growth factor receptor are rare events in bladder cancer: implications for therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(15):4671-7.
2006: Ruiz Stacey; Krupnik Yelena; Keating Michael; Chandra Joya; Palladino Michael; McConkey David
The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia.
Molecular cancer therapeutics 2006;5(7):1836-43.
2006: Pino Maria S; Shrader Marissa; Baker Cheryl H; Cognetti Francesco; Xiong Henry Q; Abbruzzese James L; McConkey David J
Transforming growth factor alpha expression drives constitutive epidermal growth factor receptor pathway activation and sensitivity to gefitinib (Iressa) in human pancreatic cancer cell lines.
Cancer research 2006;66(7):3802-12.
2006: Nawrocki Steffan T; Carew Jennifer S; Pino Maria S; Highshaw Ralph A; Andtbacka Robert H I; Dunner Kenneth; Pal Ashutosh; Bornmann William G; Chiao Paul J; Huang Peng; Xiong Henry; Abbruzzese James L; McConkey David J
Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells.
Cancer research 2006;66(7):3773-81.
2006: Carew Jennifer S; Nawrocki Steffan T; Krupnik Yelena V; Dunner Kenneth; McConkey David J; Keating Michael J; Huang Peng
Targeting endoplasmic reticulum protein transport: a novel strategy to kill malignant B cells and overcome fludarabine resistance in CLL.
Blood 2006;107(1):222-31.
2006: Trevino Jose G; Gray Michael J; Nawrocki Steffan T; Summy Justin M; Lesslie Donald P; Evans Douglas B; Sawyer Tomi K; Shakespeare William C; Watowich Stephanie S; Chiao Paul J; McConkey David J; Gallick Gary E
Src activation of Stat3 is an independent requirement from NF-kappaB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells.
Angiogenesis 2006;9(2):101-10.
2005: Nawrocki Steffan T; Carew Jennifer S; Pino Maria S; Highshaw Ralph A; Dunner Kenneth; Huang Peng; Abbruzzese James L; McConkey David J
Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis.
Cancer research 2005;65(24):11658-66.
2005: Nawrocki Steffan T; Carew Jennifer S; Dunner Kenneth; Boise Lawrence H; Chiao Paul J; Huang Peng; Abbruzzese James L; McConkey David J
Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells.
Cancer research 2005;65(24):11510-9.
2005: Pino Maria S; Nawrocki Steffan T; Cognetti Francesco; Abruzzese James L; Xiong Henry Q; McConkey David J
Prostaglandin E2 drives cyclooxygenase-2 expression via cyclic AMP response element activation in human pancreatic cancer cells.
Cancer biology & therapy 2005;4(11):1263-9.
2005: Kassouf Wassim; Dinney Colin P N; Brown Gordon; McConkey David J; Diehl Alan J; Bar-Eli Menashe; Adam Liana
Uncoupling between epidermal growth factor receptor and downstream signals defines resistance to the antiproliferative effect of Gefitinib in bladder cancer cells.
Cancer research 2005;65(22):10524-35.
2005: Lashinger Laura M; Zhu Keyi; Williams Simon A; Shrader Marissa; Dinney Colin P N; McConkey David J
Bortezomib abolishes tumor necrosis factor-related apoptosis-inducing ligand resistance via a p21-dependent mechanism in human bladder and prostate cancer cells.
Cancer research 2005;65(11):4902-8.
2005: McConkey David; Nawrocki Steffan T; Andtbacka Robert
Velcade displays promising activity in primary effusion lymphoma cells.
Cancer biology & therapy 2005;4(4):491-2.
2005: Nutt Leta K; Gogvadze Vladimir; Uthaisang Wanlaya; Mirnikjoo Banafsheh; McConkey David J; Orrenius Sten
Indirect effects of Bax and Bak initiate the mitochondrial alterations that lead to cytochrome c release during arsenic trioxide-induced apoptosis.
Cancer biology & therapy 2005;4(4):459-67.
2005: Davis Darren W; Takamori Ryan; Raut Chandrajit P; Xiong Henry Q; Herbst Roy S; Stadler Walter M; Heymach John V; Demetri George D; Rashid Asif; Shen Yu; Wen Sijin; Abbruzzese James L; McConkey David J
Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 1):678-89.
2004: Papageorgiou Angela; Lashinger Laura; Millikan Randall; Grossman H Barton; Benedict William; Dinney Colin P N; McConkey David J
Role of tumor necrosis factor-related apoptosis-inducing ligand in interferon-induced apoptosis in human bladder cancer cells.
Cancer research 2004;64(24):8973-9.
2004: Carew J S; Nawrocki S T; Xu R H; Dunner K; McConkey D J; Wierda W G; Keating M J; Huang P
Increased mitochondrial biogenesis in primary leukemia cells: the role of endogenous nitric oxide and impact on sensitivity to fludarabine.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2004;18(12):1934-40.
2004: Raut Chandrajit P; Nawrocki Steffan; Lashinger Laura M; Davis Darren W; Khanbolooki Sanaz; Xiong Henry; Ellis Lee M; McConkey David J
Celecoxib inhibits angiogenesis by inducing endothelial cell apoptosis in human pancreatic tumor xenografts.
Cancer biology & therapy 2004;3(12):1217-24.
2004: Xiong Henry Q; Herbst Roy; Faria Silvana C; Scholz Catherine; Davis Darren; Jackson Edward F; Madden Timothy; McConkey David; Hicks Marshall; Hess Kenneth; Charnsangavej Chusilp Arthur; Abbruzzese James L
A phase I surrogate endpoint study of SU6668 in patients with solid tumors.
Investigational new drugs 2004;22(4):459-66.
2004: Heymach John V; Desai Jayesh; Manola Judith; Davis Darren W; McConkey David J; Harmon David; Ryan David P; Goss Geraldine; Quigley Travis; Van den Abbeele Annick D; Silverman Stuart G; Connors Susan; Folkman Judah; Fletcher Christopher D M; Demetri George D
Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(17):5732-40.
2004: Benedict William F; Tao Ziming; Kim Chang-Soo; Zhang Xinqiao; Zhou Jain-Hua; Adam Liana; McConkey David J; Papageorgiou Angela; Munsell Mark; Philopena Jennifer; Engler Heidrun; Demers William; Maneval Daniel C; Dinney Colin P N; Connor Robert J
Intravesical Ad-IFNalpha causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-alpha protein.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(3):525-32.
2004: Highshaw Ralph A; McConkey David J; Dinney Colin P
Integrating basic science and clinical research in bladder cancer: update from the first bladder Specialized Program of Research Excellence (SPORE).
Current opinion in urology 2004;14(5):295-300.
2004: Dinney Colin P N; McConkey David J; Millikan Randall E; Wu Xifeng; Bar-Eli Menashe; Adam Liana; Kamat Ashish M; Siefker-Radtke Arlene O; Tuziak Tomasz; Sabichi Anita L; Grossman H Barton; Benedict William F; Czerniak Bogdan
Focus on bladder cancer.
Cancer cell 2004;6(2):111-6.
2004: Davis Darren W; Inoue Keiji; Dinney Colin P N; Hicklin Daniel J; Abbruzzese James L; McConkey David J
Regional effects of an antivascular endothelial growth factor receptor monoclonal antibody on receptor phosphorylation and apoptosis in human 253J B-V bladder cancer xenografts.
Cancer research 2004;64(13):4601-10.
2004: Raut Chandrajit P; Takamori Ryan K; Davis Darren W; Sweeney-Gotsch Bridget; O'Reilly Michael S; McConkey David J
Direct effects of recombinant human endostatin on tumor cell IL-8 production are associated with increased endothelial cell apoptosis in an orthotopic model of human pancreatic cancer.
Cancer biology & therapy 2004;3(7):679-87.
2004: Cortes Jorge; Thomas Deborah; Koller Charles; Giles Francis; Estey Elihu; Faderl Stefan; Garcia-Manero Guillermo; McConkey David; Ruiz Stacey L; Guerciolini Roberto; Wright John; Kantarjian Hagop
Phase I study of bortezomib in refractory or relapsed acute leukemias.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(10):3371-6.
2004: Zheng Bei; Georgakis Georgios V; Li Yang; Bharti Alok; McConkey David; Aggarwal Bharat B; Younes Anas
Induction of cell cycle arrest and apoptosis by the proteasome inhibitor PS-341 in Hodgkin disease cell lines is independent of inhibitor of nuclear factor-kappaB mutations or activation of the CD30, CD40, and RANK receptors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(9):3207-15.
2004: Pino Simona M; Xiong Henry Q; McConkey David; Abbruzzese James L
Novel therapies for pancreatic adenocarcinoma.
Current oncology reports 2004;6(3):199-206.
2004: Pino Simona M; Xiong Henry Q; McConkey David; Abbruzzese James L
Novel therapies for pancreatic adenocarcinoma.
Current gastroenterology reports 2004;6(2):119-25.
2004: Kamat Ashish M; Karashima Takashi; Davis Darren W; Lashinger Laura; Bar-Eli Menashe; Millikan Randall; Shen Yu; Dinney Colin P N; McConkey David J
The proteasome inhibitor bortezomib synergizes with gemcitabine to block the growth of human 253JB-V bladder tumors in vivo.
Molecular cancer therapeutics 2004;3(3):279-90.
2004: Nawrocki Steffan T; Sweeney-Gotsch Bridget; Takamori Ryan; McConkey David J
The proteasome inhibitor bortezomib enhances the activity of docetaxel in orthotopic human pancreatic tumor xenografts.
Molecular cancer therapeutics 2004;3(1):59-70.
2004: Davis Darren W; Shen Yu; Mullani Nizar A; Wen Sijin; Herbst Roy S; O'Reilly Michael; Abbruzzese James L; McConkey David J
Quantitative analysis of biomarkers defines an optimal biological dose for recombinant human endostatin in primary human tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(1 Pt 1):33-42.
2004: McConkey David J; Nutt Leta
Measurement of changes in intracellular calcium during apoptosis.
Methods in molecular biology (Clifton, N.J.) 2004;282():117-30.
2003: Williams Simon A; McConkey David J
The proteasome inhibitor bortezomib stabilizes a novel active form of p53 in human LNCaP-Pro5 prostate cancer cells.
Cancer research 2003;63(21):7338-44.
2003: Pahler Jessica C; Ruiz Stacey; Niemer Irina; Calvert Leslie R; Andreeff Michael; Keating Michael; Faderl Stefan; McConkey David J
Effects of the proteasome inhibitor, bortezomib, on apoptosis in isolated lymphocytes obtained from patients with chronic lymphocytic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(12):4570-7.
2003: Williams Simon; Pettaway Curtis; Song Rendu; Papandreou Christos; Logothetis Christopher; McConkey David J
Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumor xenografts.
Molecular cancer therapeutics 2003;2(9):835-43.
2003: Mian Badar M; Dinney Colin P N; Bermejo Carlos E; Sweeney Paul; Tellez Carmen; Yang X D; Gudas Jean M; McConkey David J; Bar-Eli Menashe
Fully human anti-interleukin 8 antibody inhibits tumor growth in orthotopic bladder cancer xenografts via down-regulation of matrix metalloproteases and nuclear factor-kappaB.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(8):3167-75.
2003: Karashima Takashi; Sweeney Paul; Kamat Ashish; Huang Suyun; Kim Sun J; Bar-Eli Menashe; McConkey David J; Dinney Colin P N
Nuclear factor-kappaB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(7):2786-97.
2003: Yang Peiying; Collin Peter; Madden Timothy; Chan Diana; Sweeney-Gotsch Bridget; McConkey David; Newman Robert A
Inhibition of proliferation of PC3 cells by the branched-chain fatty acid, 12-methyltetradecanoic acid, is associated with inhibition of 5-lipoxygenase.
The Prostate 2003;55(4):281-91.
2003: Davis Darren W; McConkey David J; Zhang Wei; Herbst Roy S
Antiangiogenic tumor therapy.
BioTechniques 2003;34(5):1048-50, 1052, 1054 passim.
2003: Davis Darren W; Buchholz Thomas A; Hess Kenneth R; Sahin Aysegul A; Valero Vincente; McConkey David J
Automated quantification of apoptosis after neoadjuvant chemotherapy for breast cancer: early assessment predicts clinical response.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(3):955-60.
2003: Zhang Xinqiao; Multani Asha S; Zhou Jain-Hua; Shay Jerry W; McConkey David; Dong Li; Kim Chang-Soo; Rosser Charles J; Pathak Sen; Benedict William F
Adenoviral-mediated retinoblastoma 94 produces rapid telomere erosion, chromosomal crisis, and caspase-dependent apoptosis in bladder cancer and immortalized human urothelial cells but not in normal urothelial cells.
Cancer research 2003;63(4):760-5.
2003: Buchholz Thomas A; Davis Darren W; McConkey David J; Symmans W Fraser; Valero Vicente; Jhingran Anuja; Tucker Susan L; Pusztai Lajos; Cristofanilli Massimo; Esteva Francisco J; Hortobagyi Gabriel N; Sahin Aysegul A
Chemotherapy-induced apoptosis and Bcl-2 levels correlate with breast cancer response to chemotherapy.
Cancer journal (Sudbury, Mass.) 2003;9(1):33-41.
2002: Cao Xiaobo X; Mohuiddin Imran; Chada Sunil; Mhashilkar Abner M; Ozvaran Mustafa K; McConkey David J; Miller Steven D; Daniel Jonathon C; Smythe W Roy
Adenoviral transfer of mda-7 leads to BAX up-regulation and apoptosis in mesothelioma cells, and is abrogated by over-expression of BCL-XL.
Molecular medicine (Cambridge, Mass.) 2002;8(12):869-76.
2002: Nawrocki Steffan T; Bruns Christiane J; Harbison Matthew T; Bold Richard J; Gotsch Bridget Sweeney; Abbruzzese James L; Elliott Peter; Adams Julian; McConkey David J
Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts.
Molecular cancer therapeutics 2002;1(14):1243-53.
2002: Windham T Christopher; Parikh Nila U; Siwak Doris R; Summy Justin M; McConkey David J; Kraker Alan J; Gallick Gary E
Src activation regulates anoikis in human colon tumor cell lines.
Oncogene 2002;21(51):7797-807.
2002: Bondar Victor M; Sweeney-Gotsch Bridget; Andreeff Michael; Mills Gordon B; McConkey David J
Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo.
Molecular cancer therapeutics 2002;1(12):989-97.
2002: Herbst Roy S; Mullani Nizar A; Davis Darren W; Hess Kenneth R; McConkey David J; Charnsangavej Chusilp; O'Reilly Michael S; Kim Hyung-Woo; Baker Cheryl; Roach Jennifer; Ellis Lee M; Rashid Asif; Pluda James; Bucana Corazon; Madden Timothy L; Tran Hai T; Abbruzzese James L
Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(18):3804-14.
2002: Herbst Roy S; Hess Kenneth R; Tran Hai T; Tseng Jennifer E; Mullani Nizar A; Charnsangavej Chusilp; Madden Timothy; Davis Darren W; McConkey David J; O'Reilly Michael S; Ellis Lee M; Pluda James; Hong Waun K; Abbruzzese James L
Phase I study of recombinant human endostatin in patients with advanced solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(18):3792-803.
2002: Guo Zijian; Clydesdale Gavin; Cheng Jinke; Kim Kihwan; Gan Lin; McConkey David J; Ullrich Stephen E; Zhuang Yuan; Su Bing
Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction.
Molecular and cellular biology 2002;22(16):5761-8.
2002: Nutt Leta K; Chandra Joya; Pataer Abujiang; Fang Bingliang; Roth Jack A; Swisher Stephen G; O'Neil Roger G; McConkey David J
Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis.
The Journal of biological chemistry 2002;277(23):20301-8.
2002: Santamaria A B; Davis D W; Nghiem D X; McConkey D J; Ullrich S E; Kapoor M; Lozano G; Ananthaswamy H N
p53 and Fas ligand are required for psoralen and UVA-induced apoptosis in mouse epidermal cells.
Cell death and differentiation 2002;9(5):549-60.
2002: Bondar Victor M; McConkey David J
Anoikis is regulated by BCL-2-independent pathways in human prostate carcinoma cells.
The Prostate 2002;51(1):42-9.
2002: Nutt Leta K; Pataer Abujiang; Pahler Jessica; Fang Bingliang; Roth Jack; McConkey David J; Swisher Stephen G
Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores.
The Journal of biological chemistry 2002;277(11):9219-25.
2002: Termuhlen Paula M; Sweeney-Gotsch Bridget M; Berman Russell S; Ellis Lee M; Bucana Corazon; Shen Yu; Cleary Karen R; McConkey David J
Increased apoptosis in metastatic human colonic adenocarcinomas.
Cancer biology & therapy 2002;1(1):58-63.
2001: Cao X X; Mohuiddin I; Ece F; McConkey D J; Smythe W R
Histone deacetylase inhibitor downregulation of bcl-xl gene expression leads to apoptotic cell death in mesothelioma.
American journal of respiratory cell and molecular biology 2001;25(5):562-8.
2001: Solorzano C C; Jung Y D; Bucana C D; McConkey D J; Gallick G E; McMahon G; Ellis L M
In vivo intracellular signaling as a marker of antiangiogenic activity.
Cancer research 2001;61(19):7048-51.
2001: Slaton J W; Karashima T; Perrotte P; Inoue K; Kim S J; Izawa J; Kedar D; McConkey D J; Millikan R; Sweeney P; Yoshikawa C; Shuin T; Dinney C P
Treatment with low-dose interferon-alpha restores the balance between matrix metalloproteinase-9 and E-cadherin expression in human transitional cell carcinoma of the bladder.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(9):2840-53.
2001: Nyormoi O; Wang Z; Doan D; Ruiz M; McConkey D; Bar-Eli M
Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells.
Molecular and cellular biology 2001;21(15):4856-67.
2001: Shaheen R M; Tseng W W; Davis D W; Liu W; Reinmuth N; Vellagas R; Wieczorek A A; Ogura Y; McConkey D J; Drazan K E; Bucana C D; McMahon G; Ellis L M
Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms.
Cancer research 2001;61(4):1464-8.
2001: McConkey D J; Nutt L K
Calcium flux measurements in apoptosis.
Methods in cell biology 2001;66():229-46.
2000: Inoue K; Slaton J W; Perrotte P; Davis D W; Bruns C J; Hicklin D J; McConkey D J; Sweeney P; Radinsky R; Dinney C P
Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(12):4874-84.
2000: Yano S; Shinohara H; Herbst R S; Kuniyasu H; Bucana C D; Ellis L M; Davis D W; McConkey D J; Fidler I J
Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis.
Cancer research 2000;60(17):4959-67.
2000: Bruns C J; Liu W; Davis D W; Shaheen R M; McConkey D J; Wilson M R; Bucana C D; Hicklin D J; Ellis L M
Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases.
Cancer 2000;89(3):488-99.
2000: Multani A S; Ozen M; Narayan S; Kumar V; Chandra J; McConkey D J; Newman R A; Pathak S
Caspase-dependent apoptosis induced by telomere cleavage and TRF2 loss.
Neoplasia (New York, N.Y.) 2000;2(4):339-45.
2000: McConkey D J; Lin Y; Nutt L K; Ozel H Z; Newman R A
Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells.
Cancer research 2000;60(14):3807-12.
2000: Inoue K; Slaton J W; Davis D W; Hicklin D J; McConkey D J; Karashima T; Radinsky R; Dinney C P
Treatment of human metastatic transitional cell carcinoma of the bladder in a murine model with the anti-vascular endothelial growth factor receptor monoclonal antibody DC101 and paclitaxel.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(7):2635-43.
2000: Jean D; Tellez C; Huang S; Davis D W; Bruns C J; McConkey D J; Hinrichs S H; Bar-Eli M
Inhibition of tumor growth and metastasis of human melanoma by intracellular anti-ATF-1 single chain Fv fragment.
Oncogene 2000;19(22):2721-30.
2000: Bruns C J; Harbison M T; Davis D W; Portera C A; Tsan R; McConkey D J; Evans D B; Abbruzzese J L; Hicklin D J; Radinsky R
Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):1936-48.
2000: Bruns C J; Shinohara H; Harbison M T; Davis D W; Nelkin G; Killion J J; McConkey D J; Dong Z; Fidler I J
Therapy of human pancreatic carcinoma implants by irinotecan and the oral immunomodulator JBT 3002 is associated with enhanced expression of inducible nitric oxide synthase in tumor-infiltrating macrophages.
Cancer research 2000;60(1):2-7.
1999: Shaheen R M; Davis D W; Liu W; Zebrowski B K; Wilson M R; Bucana C D; McConkey D J; McMahon G; Ellis L M
Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis.
Cancer research 1999;59(21):5412-6.
1999: Davies M A; Koul D; Dhesi H; Berman R; McDonnell T J; McConkey D; Yung W K; Steck P A
Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN.
Cancer research 1999;59(11):2551-6.
1999: Bold R J; Hess K R; Pearson A S; Grau A M; Sinicrope F A; Jennings M; McConkey D J; Bucana C D; Cleary K R; Hallin P A; Chiao P J; Abbruzzese J L; Evans D B
Prognostic factors in resectable pancreatic cancer: p53 and bcl-2.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 1999;3(3):263-77.
1999: McConkey D J; Chandra J
Protease activation and glucocorticoid-induced apoptosis in chronic lymphocytic leukemia.
Leukemia & lymphoma 1999;33(5-6):421-31.
1999: Bold R J; Chandra J; McConkey D J
Gemcitabine-induced programmed cell death (apoptosis) of human pancreatic carcinoma is determined by Bcl-2 content.
Annals of surgical oncology 1999;6(3):279-85.
1999: Diaz C; Lee A T; McConkey D J; Schroit A J
Phosphatidylserine externalization during differentiation-triggered apoptosis of erythroleukemic cells.
Cell death and differentiation 1999;6(3):218-26.
1998: Bouvet M; Bold R J; Lee J; Evans D B; Abbruzzese J L; Chiao P J; McConkey D J; Chandra J; Chada S; Fang B; Roth J A
Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments]
Annals of surgical oncology 1998;5(8):681-8.
1998: Chandra J; Niemer I; Gilbreath J; Kliche K O; Andreeff M; Freireich E J; Keating M; McConkey D J
Proteasome inhibitors induce apoptosis in glucocorticoid-resistant chronic lymphocytic leukemic lymphocytes.
Blood 1998;92(11):4220-9.
1998: Jean D; Harbison M; McConkey D J; Ronai Z; Bar-Eli M
CREB and its associated proteins act as survival factors for human melanoma cells.
The Journal of biological chemistry 1998;273(38):24884-90.
1998: Voehringer D W; McConkey D J; McDonnell T J; Brisbay S; Meyn R E
Bcl-2 expression causes redistribution of glutathione to the nucleus.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):2956-60.
1997: Bold R J; Termuhlen P M; McConkey D J
Apoptosis, cancer and cancer therapy.
Surgical oncology 1997;6(3):133-42.
1997: Chandra J; Gilbreath J; Freireich E J; Kliche K O; Andreeff M; Keating M; McConkey D J
Protease activation is required for glucocorticoid-induced apoptosis in chronic lymphocytic leukemic lymphocytes.
Blood 1997;90(9):3673-81.
1997: Mirkovic N; Voehringer D W; Story M D; McConkey D J; McDonnell T J; Meyn R E
Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols.
Oncogene 1997;15(12):1461-70.
1997: Xie K; Wang Y; Huang S; Xu L; Bielenberg D; Salas T; McConkey D J; Jiang W; Fidler I J
Nitric oxide-mediated apoptosis of K-1735 melanoma cells is associated with downregulation of Bcl-2.
Oncogene 1997;15(7):771-9.
1996: McConkey D J; Greene G; Pettaway C A
Apoptosis resistance increases with metastatic potential in cells of the human LNCaP prostate carcinoma line.
Cancer research 1996;56(24):5594-9.
1996: Huang S; Luca M; Gutman M; McConkey D J; Langley K E; Lyman S D; Bar-Eli M
Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential.
Oncogene 1996;13(11):2339-47.
1996: Xie K; Huang S; Wang Y; Beltran P J; Juang S H; Dong Z; Reed J C; McDonnell T J; McConkey D J; Fidler I J
Bcl-2 protects cells from cytokine-induced nitric-oxide-dependent apoptosis.
Cancer immunology, immunotherapy : CII 1996;43(2):109-15.
1996: McConkey D J; Goodrich D; Bucana C; Klostergaard J
The human retinoblastoma gene product suppresses ceramide-induced apoptosis in human bladder tumor cells.
Oncogene 1996;13(8):1693-700.
1996: McConkey D J
Calcium-dependent, interleukin 1-converting enzyme inhibitor-insensitive degradation of lamin B1 and DNA fragmentation in isolated thymocyte nuclei.
The Journal of biological chemistry 1996;271(37):22398-406.
1996: McConkey D J; Orrenius S
The role of calcium in the regulation of apoptosis.
Journal of leukocyte biology 1996;59(6):775-83.
1996: Marin M C; Fernandez A; Bick R J; Brisbay S; Buja L M; Snuggs M; McConkey D J; von Eschenbach A C; Keating M J; McDonnell T J
Apoptosis suppression by bcl-2 is correlated with the regulation of nuclear and cytosolic Ca2+.
Oncogene 1996;12(11):2259-66.
1996: Warren A P; Patel K; McConkey D J; Palacios R
CD98: a type II transmembrane glycoprotein expressed from the beginning of primitive and definitive hematopoiesis may play a critical role in the development of hematopoietic cells.
Blood 1996;87(9):3676-87.
1996: McConkey D J; Chandra J; Wright S; Plunkett W; McDonnell T J; Reed J C; Keating M
Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(7):2624-30.
1996: McConkey D J
The role of calcium in the regulation of apoptosis.
Scanning microscopy 1996;10(3):777-93; discussion 793-4.
1995: Fernandez A; Kiefer J; Fosdick L; McConkey D J
Oxygen radical production and thiol depletion are required for Ca(2+)-mediated endogenous endonuclease activation in apoptotic thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(11):5133-9.
1995: Kiefer J; Okret S; Jondal M; McConkey D J
Functional glucocorticoid receptor expression is required for cAMP-mediated apoptosis in a human leukemic T cell line.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4525-8.
1995: McConkey D J; Fernandez A; Trent J; Ananthaswamy H N
Oncogene regulation of endonuclease activation in apoptosis.
Cancer letters 1995;94(1):9-16.
1995: Neamati N; Fernandez A; Wright S; Kiefer J; McConkey D J
Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(8):3788-95.
1995: Fernandez A; Fosdick L J; Marin M C; Diaz C; McDonnell T J; Ananthaswamy H N; McConkey D J
Differential regulation of endogenous endonuclease activation in isolated murine fibroblast nuclei by ras and bcl-2.
Oncogene 1995;10(4):769-74.
1994: McConkey D J; Fosdick L; D'Adamio L; Jondal M; Orrenius S
Co-receptor (CD4/CD8) engagement enhances CD3-induced apoptosis in thymocytes. Implications for negative selection.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(6):2436-43.
1993: Moingeon P; Rodewald H R; McConkey D; Mildonian A; Awad K; Reinherz E L
Generation of natural killer cells from both Fc gamma RII/III+ and Fc gamma RII/III- murine fetal liver progenitors.
Blood 1993;82(5):1453-62.
1993: Hussey R E; Clayton L K; Diener A; McConkey D J; Howard F D; Rodewald H R; D'Adamio L; Dallenbach F; Stein H; Schmidt E V
Overexpression of CD3 eta during thymic development does not alter the negative selection process.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(4):1183-94.
1992: Howard F D; Moingeon P; Moebius U; McConkey D J; Yandava B; Gennert T E; Reinherz E L
The CD3 zeta cytoplasmic domain mediates CD2-induced T cell activation.
The Journal of experimental medicine 1992;176(1):139-45.
1992: Koyasu S; McConkey D J; Clayton L K; Abraham S; Yandava B; Katagiri T; Moingeon P; Yamamoto T; Reinherz E L
Phosphorylation of multiple CD3 zeta tyrosine residues leads to formation of pp21 in vitro and in vivo. Structural changes upon T cell receptor stimulation.
The Journal of biological chemistry 1992;267(5):3375-81.
1992: Moingeon P; Lucich J L; McConkey D J; Letourneur F; Malissen B; Kochan J; Chang H C; Rodewald H R; Reinherz E L
CD3 zeta dependence of the CD2 pathway of activation in T lymphocytes and natural killer cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1492-6.
1991: Bauer A; McConkey D J; Howard F D; Clayton L K; Novick D; Koyasu S; Reinherz E L
Differential signal transduction via T-cell receptor CD3 zeta 2, CD3 zeta-eta, and CD3 eta 2 isoforms.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3842-6.

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