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Patrick McConnell

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Noel A Powell; John Quin; Derek J Sheehan; Sangita M Baxi; Cornel Catana; Fred Ciske; Amy Delaney; Jennifer K Hoffman; Michael D Kaufman; Jeffrey T Kohrt; Patrick McConnell; Jeffrey F Ohren; Lisa A Perrin; Jeremy J Edmunds
Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.
Artem G Evdokimov; Marlene Mekel; Kim Hutchings; Lakshmi Narasimhan; Tod Holler; Teresa McGrath; Bryan Beattie; Eric Fauman; Chunhong Yan; Holly Heaslet; Richard Walter; Barry Finzel; Jeffrey Ohren; Patrick McConnell; Timothy Braden; Fang Sun; Cindy Spessard; Craig Banotai; Loola Al-Kassim; Weijun Ma; Paul Wengender; Denis Kole; Norman Garceau; Peter Toogood; Jia Liu
Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.
Adam R Johnson; Alexander Pavlovsky; Daniel F Ortwine; Faith Prior; Chiu-Fai Man; Dirk A Bornemeier; Craig Banotai; W Thomas Mueller; Patrick McConnell; Chunhong Yan; Vijay Baragi; Charles Lesch; W Howard Roark; Michael Wilson; Kaushik Datta; Roberto Guzman; Hyo-Kyung Han; Richard D Dyer
Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects.

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All Publications

2013: Noel A Powell; John Quin; Derek J Sheehan; Sangita M Baxi; Cornel Catana; Fred Ciske; Amy Delaney; Jennifer K Hoffman; Michael D Kaufman; Jeffrey T Kohrt; Patrick McConnell; Jeffrey F Ohren; Lisa A Perrin; Jeremy J Edmunds
Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.
Bioorganic & medicinal chemistry letters 2013;23(4):1046-50.
2008: Artem G Evdokimov; Marlene Mekel; Kim Hutchings; Lakshmi Narasimhan; Tod Holler; Teresa McGrath; Bryan Beattie; Eric Fauman; Chunhong Yan; Holly Heaslet; Richard Walter; Barry Finzel; Jeffrey Ohren; Patrick McConnell; Timothy Braden; Fang Sun; Cindy Spessard; Craig Banotai; Loola Al-Kassim; Weijun Ma; Paul Wengender; Denis Kole; Norman Garceau; Peter Toogood; Jia Liu
Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.
Journal of structural biology 2008;162(1):152-69.
2007: Adam R Johnson; Alexander Pavlovsky; Daniel F Ortwine; Faith Prior; Chiu-Fai Man; Dirk A Bornemeier; Craig Banotai; W Thomas Mueller; Patrick McConnell; Chunhong Yan; Vijay Baragi; Charles Lesch; W Howard Roark; Michael Wilson; Kaushik Datta; Roberto Guzman; Hyo-Kyung Han; Richard D Dyer
Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects.
The Journal of biological chemistry 2007;282(38):27781-91.
2007: Noel A Powell; Fred Ciske; Cuiman Cai; Daniel D Holsworth; Ken Mennen; Chad A Van Huis; Mehran Jalaie; Jacqueline Day; Michelle Mastronardi; Patrick McConnell; Igor Mochalkin; Erli Zhang; Michael J Ryan; John Bryant; Wendy Collard; Suzie Ferreira; Chungang Gu; Roxane Collins; Jeremy J Edmunds
Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors.
Bioorganic & medicinal chemistry 2007;15(17):5912-49.
2007: Daniel D Holsworth; Mehran Jalaie; Thomas R Belliotti; Cuiman Cai; Wendy Collard; Suzie Ferreira; Noel A Powell; Michael A Stier; Erli Zhang; Patrick McConnell; Igor Mochalkin; Michael J Ryan; John Bryant; Tingsheng Li; Aparna Kasani; Rajendra Subedi; Samarendra N Maiti; Jeremy J Edmunds
Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(13):3575-80.
2007: Ronald W Sarver; Jeanette Peevers; Wayne L Cody; Fred Ciske; Jim Dyer; S Donald Emerson; Jeanne C Hagadorn; Daniel D Holsworth; Mehran Jalaie; Michael Kaufman; Michelle Mastronardi; Patrick McConnell; Noel A Powell; John Quin; Chad A Van Huis; Erli Zhang; Igor Mochalkin
Binding thermodynamics of substituted diaminopyrimidine renin inhibitors.
Analytical biochemistry 2007;360(1):30-40.
2006: Daniel D Holsworth; Cuiman Cai; Xue-Min Cheng; Wayne L Cody; Dennis M Downing; Noe Erasga; Chitase Lee; Noel A Powell; Jeremy J Edmunds; Michael A Stier; Mehran Jalaie; Erli Zhang; Patrick McConnell; Michael J Ryan; John Bryant; Tingsheng Li; Aparna Kasani; Eric Hall; Rajendra Subedi; Mohammad Rahim; Samarendra Maiti
Ketopiperazine-based renin inhibitors: optimization of the "C" ring.
Bioorganic & medicinal chemistry letters 2006;16(9):2500-4.
2006: Lain-Yen Hu; Peter A Boxer; Suzanne R Kesten; Huangshu J Lei; David J Wustrow; David W Moreland; Liming Zhang; Kyunghye Ahn; Todd R Ryder; Xiaohong Liu; John R Rubin; Kelly Fahnoe; Richard T Carroll; Satavisha Dutta; Douglass C Fahnoe; Albert W Probert; Robin L Roof; Michael F Rafferty; Catherine R Kostlan; Jeffrey D Scholten; Molly Hood; Xiao-Dan Ren; Gerald P Schielke; Ti-Zhi Su; Charles P Taylor; Anil Mistry; Patrick McConnell; Charles A Hasemann; Jeffrey F Ohren
The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases.
Bioorganic & medicinal chemistry letters 2006;16(9):2337-40.
2004: Jeffrey F Ohren; Huifen Chen; Alexander Pavlovsky; Christopher Whitehead; Erli Zhang; Peter Kuffa; Chunhong Yan; Patrick McConnell; Cindy Spessard; Craig Banotai; W Thomas Mueller; Amy Delaney; Charles Omer; Judith Leopold; David T Dudley; Iris K Leung; Cathlin Flamme; Joseph Warmus; Michael Kaufman; Stephen Barrett; Haile Tecle; Charles A Hasemann
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.
Nature structural & molecular biology 2004;11(12):1192-7.
2000: MH Parker; Daniel F Ortwine; PM O'Brien; Elizabeth A Lunney; Craig Banotai; W Thomas Mueller; Patrick McConnell; Christie G Brouillette
Stereoselective binding of an enantiomeric pair of stromelysin-1 inhibitors caused by conformational entropy factors.
Bioorganic & medicinal chemistry letters 2000;10(21):2427-30.
1999: T S Gipson; NM Bless; Thomas P Shanley; LD Crouch; M R Bleavins; Ellen M Younkin; J Vidya Sarma; DF Gibbs; W Tefera; Patrick McConnell; W T Mueller; Kent J Johnson; Peter A Ward
Regulatory effects of endogenous protease inhibitors in acute lung inflammatory injury.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3653-62.
1999: M D Reily; A M Bokman; J Offord; Patrick McConnell
Nuclear magnetic resonance spectroscopy of peptide ion channel ligands: cloning and expression as aid to evaluation of structural and dynamic properties.
Methods in enzymology 1999;294():92-117.
1998: Joseph A Loo; Tod P Holler; S K Foltin; Patrick McConnell; Craig Banotai; N M Horne; W Thomas Mueller; T I Stevenson; DP Mack
Application of electrospray ionization mass spectrometry for studying human immunodeficiency virus protein complexes.
Proteins 1998;Suppl 2():28-37.
1997: Mark S Plummer; D R Holland; Aurash B Shahripour; Elizabeth A Lunney; J H Fergus; J S Marks; Patrick McConnell; W Thomas Mueller; Tomi K Sawyer
Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand.
Journal of medicinal chemistry 1997;40(23):3719-25.
1996: Kevin Thornton; W Thomas Mueller; Patrick McConnell; G Zhu; Alan Saltiel; V Thanabal
Nuclear magnetic resonance solution structure of the growth factor receptor-bound protein 2 Src homology 2 domain.
Biochemistry 1996;35(36):11852-64.
1996: Nywana Sizemore; R C Dudeck; C M Barksdale; G D Nordblom; W Thomas Mueller; Patrick McConnell; DS Wright; A Guglietta; B S Kuo
Development and validation of two solid-phase enzyme immunoassays (ELISA) for quantitation of human epidermal growth factors (hEGFs).
Pharmaceutical research 1996;13(7):1088-94.