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Malcolm McConville

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Cyrille Y Botté; Ross L Coppel; PK Crellin; Ming Kalanon; James I Macrae; Eric Maréchal; Malcolm J McConville; Kylie A Mullin; Thusitha W T Rupasinghe; Melanie J Shears; Timothy P Spurck; Yoshiki Yamaryo-Botté; Geoffrey I McFadden
Atypical lipid composition in the purified relict plastid (apicoplast) of malaria parasites.
Benjamin Cao; Xingqiang Chen; Ross L Coppel; PK Crellin; George N Khairallah; Kirstee L Martin; Malcolm J McConville; Roisin M O'Flaherty; Richard A J O'Hair; Julie E Ralton; Mark B Richardson; Thusita W T Rupasinghe; Yoshiki Yamaryo-Botte; Spencer J Williams
Synthesis, structural elucidation, and biochemical analysis of immunoactive glucuronosyl diacylglycerides of mycobacteria and corynebacteria.
Fiona M Sansom; Eleanor C Saunders; Leonie Tang; Thomas Naderer; Julie E Ralton; Malcolm J McConville
Leishmania major methionine sulfoxide reductase A is required for resistance to oxidative stress and efficient replication in macrophages.

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All Publications

2013: Cyrille Y Botté; Ross L Coppel; PK Crellin; Ming Kalanon; James I Macrae; Eric Maréchal; Malcolm J McConville; Kylie A Mullin; Thusitha W T Rupasinghe; Melanie J Shears; Timothy P Spurck; Yoshiki Yamaryo-Botté; Geoffrey I McFadden
Atypical lipid composition in the purified relict plastid (apicoplast) of malaria parasites.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(18):7506-11.
2013: Benjamin Cao; Xingqiang Chen; Ross L Coppel; PK Crellin; George N Khairallah; Kirstee L Martin; Malcolm J McConville; Roisin M O'Flaherty; Richard A J O'Hair; Julie E Ralton; Mark B Richardson; Thusita W T Rupasinghe; Yoshiki Yamaryo-Botte; Spencer J Williams
Synthesis, structural elucidation, and biochemical analysis of immunoactive glucuronosyl diacylglycerides of mycobacteria and corynebacteria.
The Journal of organic chemistry 2013;78(6):2175-90.
2013: Fiona M Sansom; Eleanor C Saunders; Leonie Tang; Thomas Naderer; Julie E Ralton; Malcolm J McConville
Leishmania major methionine sulfoxide reductase A is required for resistance to oxidative stress and efficient replication in macrophages.
PloS one 2013;8(2):e56064.
2013: Jillian C Danne; Sebastian G Gornik; James I Macrae; Malcolm J McConville; Ross F Waller
Alveolate mitochondrial metabolic evolution: dinoflagellates force reassessment of the role of parasitism as a driver of change in apicomplexans.
Molecular biology and evolution 2013;30(1):123-39.
2012: Alysha M De Livera; David De Souza; Daniel A Dias; Malcolm J McConville; James Pyke; Ute Roessner; Thusitha Rupasinghe; Dedreia Tull; Terence P Speed
Normalizing and integrating metabolomics data.
Analytical chemistry 2012;84(24):10768-76.
2012: Arek K Rainczuk; Torsten Seemann; Timothy P Stinear; Yoshiki Yamaryo-Botte; Rajini Brammananth; Ross L Coppel; Malcolm J McConville; PK Crellin
The lipoprotein LpqW is essential for the mannosylation of periplasmic glycolipids in Corynebacteria.
The Journal of biological chemistry 2012;287(51):42726-38.
2012: Lars Kjer-Nielsen; Lyudmila Kostenko; Jérôme Le Nours; Ligong Liu; Mugdha Bhati; Zhenjun Chen; Alexandra J Corbett; Nadine L Dudek; David P Fairlie; Dale I Godfrey; George N Khairallah; Malcolm J McConville; Bronwyn Meehan; Richard A J O'Hair; Onisha Patel; Anthony W Purcell; Rangsima Reantragoon; Jamie Rossjohn; Nicholas A Williamson; James McCluskey
MR1 presents microbial vitamin B metabolites to MAIT cells.
Nature 2012;491(7426):717-23.
2012: James I MacRae; Amsha Nahid; Lilach Sheiner; Boris Striepen; Christopher J Tonkin; Malcolm J McConville
Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii.
Cell host & microbe 2012;12(5):682-92.
2012: Darren J Creek; Malcolm J McConville; Jana Anderson; Michael P Barrett
Metabolomic analysis of trypanosomatid protozoa.
Molecular and biochemical parasitology 2012;181(2):73-84.
2012: Sean O'Callaghan; Moshe Olshansky; Ute Roessner; Dedreia L Tull; Qiao Wang; Bill Appelbe; Antony Bacic; David P De Souza; Tim Erwin; Luke Hodkinson; Andrew Isaac; Malcolm J McConville; Vladimir A Likic
PyMS: a Python toolkit for processing of gas chromatography-mass spectrometry (GC-MS) data. Application and comparative study of selected tools.
BMC bioinformatics 2012;13():115.
2012: Eleanor C Saunders; James I MacRae; Malcolm J McConville; Thomas Naderer; Milica Ng; Vladimir A Likic
LeishCyc: a guide to building a metabolic pathway database and visualization of metabolomic data.
Methods in molecular biology (Clifton, N.J.) 2012;881():505-29.
2012: Phillip van der Peet; Malcolm J McConville; Julie E Ralton; Spencer J Williams
Discovery of inhibitors of Leishmania β-1,2-mannosyltransferases using a click-chemistry-derived guanosine monophosphate library.
PloS one 2012;7(2):e32642.
2012: Dedreia Tull; Thomas Naderer; Paul R Gooley; Joanne Heng; Malcolm J McConville
Acylation-dependent and-independent membrane targeting and distinct functions of small myristoylated proteins (SMPs) in Leishmania major.
International journal for parasitology 2012;42(3):239-47.
2011: Berin A Boughton; Jairus Bowne; Damien L Callahan; Malcolm J McConville; Amsha Nahid; Thusita Rupasinghe; Claudio Silva; Dedreja L Tull; Antony Bacic; Ute Roessner
Comprehensive profiling and quantitation of amine group containing metabolites.
Analytical chemistry 2011;83(19):7523-30.
2011: Cyrille Y Botté; Ross L Coppel; Paul Crellin; Jan Janouskovec; Patrick J Keeling; Eric Maréchal; Malcolm J McConville; Thusita Rupasinghe; Yoshiki Yamaryo-Botté; Geoffrey I McFadden
Identification of plant-like galactolipids in Chromera velia, a photosynthetic relative of malaria parasites.
The Journal of biological chemistry 2011;286(34):29893-903.
2011: Yasu S Morita; Takeshi Fukuda; Chubert B C Sena; Yoshiki Yamaryo-Botte; Malcolm J McConville; Taroh Kinoshita
Inositol lipid metabolism in mycobacteria: biosynthesis and regulatory mechanisms.
Biochimica et biophysica acta 2011;1810(6):630-41.
2011: James E Vince; Dedreia Tull; Scott M Landfear; Malcolm J McConville
Lysosomal degradation of Leishmania hexose and inositol transporters is regulated in a stage-, nutrient- and ubiquitin-dependent manner.
International journal for parasitology 2011;41(7):791-800.
2011: Thomas Naderer; Orwa Dandash; Malcolm J McConville
Calcineurin is required for Leishmania major stress response pathways and for virulence in the mammalian host.
Molecular microbiology 2011;80(2):471-80.
2011: Michael J Dagley; Ian Gentle; Traude H Beilharz; Filomena A Pettolino; Julianne T Djordjevic; Tricia L Lo; Nathalie Uwamahoro; Thusitha Rupasinghe; Dedreja L Tull; Malcolm J McConville; Cecile Beaurepaire; André Nantel; Trevor Lithgow; Aaron P Mitchell; Ana Traven
Cell wall integrity is linked to mitochondria and phospholipid homeostasis in Candida albicans through the activity of the post-transcriptional regulator Ccr4-Pop2.
Molecular microbiology 2011;79(4):968-89.
2011: Thomas Naderer; Malcolm J McConville
Intracellular growth and pathogenesis of Leishmania parasites.
Essays in biochemistry 2011;51():81-95.
2011: Malcolm J McConville; Thomas Naderer
Metabolic pathways required for the intracellular survival of Leishmania.
Annual review of microbiology 2011;65():543-61.
2010: Eleanor C Saunders; David P De Souza; Thomas Naderer; Marijke F Sernee; Julie E Ralton; Maria A Doyle; James I Macrae; Jenny L Chambers; Joanne Heng; Amsha Nahid; Vladimir A Likic; Malcolm J McConville
Central carbon metabolism of Leishmania parasites.
Parasitology 2010;137(9):1303-13.
2010: Wai Yee Low; Susanne C Feil; Hooi Ling Ng; Michael A Gorman; Craig J Morton; James Pyke; Malcolm J McConville; Michael Bieri; Yee-Foong Mok; Charles Robin; Paul R Gooley; Michael W Parker; Philip Batterham
Recognition and detoxification of the insecticide DDT by Drosophila melanogaster glutathione S-transferase D1.
Journal of molecular biology 2010;399(3):358-66.
2010: Yasu S Morita; Yoshiki Yamaryo-Botte; Kana Miyanagi; Judy M Callaghan; John H Patterson; Paul K Crellin; Ross Coppel; Helen Billman-Jacobe; Taroh Kinoshita; Malcolm J McConville
Stress-induced synthesis of phosphatidylinositol 3-phosphate in mycobacteria.
The Journal of biological chemistry 2010;285(22):16643-50.
2010: John R Sheedy; Peter R Ebeling; Paul R Gooley; Malcolm J McConville
A sample preparation protocol for 1H nuclear magnetic resonance studies of water-soluble metabolites in blood and urine.
Analytical biochemistry 2010;398(2):263-5.
2010: Dedreia Tull; Thomas Naderer; Timothy P Spurck; Haydyn D T Mertens; Joanne Heng; Geoffrey I McFadden; Paul R Gooley; Malcolm J McConville
Membrane protein SMP-1 is required for normal flagellum function in Leishmania.
Journal of cell science 2010;123(Pt 4):544-54.
2010: Vladimir A Likić; Malcolm J McConville; Trevor Lithgow; Antony Bacic
Systems biology: the next frontier for bioinformatics.
Advances in bioinformatics 2010;():268925.
2010: Thomas Naderer; Joanne Heng; Malcolm J McConville
Evidence that intracellular stages of Leishmania major utilize amino sugars as a major carbon source.
PLoS pathogens 2010;6(12):e1001245.
2009: Maria A Doyle; James I MacRae; David P De Souza; Eleanor C Saunders; Malcolm J McConville; Vladimir A Likić
LeishCyc: a biochemical pathways database for Leishmania major.
BMC systems biology 2009;3():57.
2008: Thomas Naderer; Edmund Wee; Malcolm J McConville
Role of hexosamine biosynthesis in Leishmania growth and virulence.
Molecular microbiology 2008;69(4):858-69.
2008: James E Vince; Dedreia L Tull; Timothy Spurck; Merran C Derby; Geoffrey I McFadden; Paul A Gleeson; Suzanne Gokool; Malcolm J McConville
Leishmania adaptor protein-1 subunits are required for normal lysosome traffic, flagellum biogenesis, lipid homeostasis, and adaptation to temperatures encountered in the mammalian host.
Eukaryotic cell 2008;7(8):1256-67.
2008: Dale Christiansen; Julie Milland; Effie Mouhtouris; Hilary Vaughan; Daniel G Pellicci; Malcolm J McConville; Dale I Godfrey; Mauro S Sandrin
Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation.
PLoS biology 2008;6(7):e172.
2008: PK Crellin; Svetozar Kovacevic; Kirstee L Martin; Rajini Brammananth; Yasu S Morita; Helen Billman-Jacobe; Malcolm J McConville; Ross Coppel
Mutations in pimE restore lipoarabinomannan synthesis and growth in a Mycobacterium smegmatis lpqW mutant.
Journal of bacteriology 2008;190(10):3690-9.
2008: David J Lea-Smith; Kirstee L Martin; James S Pyke; Dedreia Tull; Malcolm J McConville; Ross Coppel; PK Crellin
Analysis of a new mannosyltransferase required for the synthesis of phosphatidylinositol mannosides and lipoarbinomannan reveals two lipomannan pools in corynebacterineae.
The Journal of biological chemistry 2008;283(11):6773-82.
2008: Pavla Bojarová; Emma Denehy; Ian Walker; Karen Loft; David P De Souza; L W Lawrence Woo; Barry V L Potter; Malcolm J McConville; Spencer J Williams
Direct evidence for ArO-S bond cleavage upon inactivation of Pseudomonas aeruginosa arylsulfatase by aryl sulfamates.
Chembiochem : a European journal of chemical biology 2008;9(4):613-23.
2008: Thomas Naderer; Malcolm J McConville
The Leishmania-macrophage interaction: a metabolic perspective.
Cellular microbiology 2008;10(2):301-8.
2007: Haydyn D T Mertens; judy callaghan; James D Swarbrick; Malcolm J McConville; Paul R Gooley
A high-resolution solution structure of a trypanosomatid FYVE domain.
Protein science : a publication of the Protein Society 2007;16(11):2552-9.
2007: Cameron R Stewart; Antonio Haw; Roland Lopez; Thomas O McDonald; judy callaghan; Malcolm J McConville; Kathryn J Moore; Geoffrey J Howlett; Kevin D O'Brien
Serum amyloid P colocalizes with apolipoproteins in human atheroma: functional implications.
Journal of lipid research 2007;48(10):2162-71.
2007: Malcolm J McConville; David P De Souza; Eleanor Saunders; Vladimir A Likic; Thomas Naderer
Living in a phagolysosome; metabolism of Leishmania amastigotes.
Trends in parasitology 2007;23(8):368-75.
2007: Viraj N Perera; Irving Nachamkin; Huong Ung; John H Patterson; Malcolm J McConville; Peter J Coloe; Benjamin N Fry
Molecular mimicry in Campylobacter jejuni: role of the lipo-oligosaccharide core oligosaccharide in inducing anti-ganglioside antibodies.
FEMS immunology and medical microbiology 2007;50(1):27-36.
2007: Abigail Clements; Dedreia Tull; Adam W Jenney; Jacinta L Farn; Sang-Hyun Kim; Russell E Bishop; Joseph B McPhee; Robert E W Hancock; Elizabeth L Hartland; Martin J Pearse; Odilia L C Wijburg; David C Jackson; Malcolm J McConville; Richard A Strugnell
Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides.
The Journal of biological chemistry 2007;282(21):15569-77.
2007: Daniel H D Gray; Dedreia Tull; Tomoo Ueno; Natalie Seach; Brendan J Classon; Ann P Chidgey; Malcolm J McConville; Richard L Boyd
A unique thymic fibroblast population revealed by the monoclonal antibody MTS-15.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4956-65.
2007: David J Lea-Smith; James S Pyke; Dedreia Tull; Malcolm J McConville; Ross Coppel; Paul K Crellin
The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan.
The Journal of biological chemistry 2007;282(15):11000-8.
2007: Zoran Dinev; Carlie T Gannon; Caroline Egan; Jacinta A Watt; Malcolm J McConville; Spencer J Williams
Galactose-derived phosphonate analogues as potential inhibitors of phosphatidylinositol biosynthesis in mycobacteria.
Organic & biomolecular chemistry 2007;5(6):952-9.
2007: Mark D Robinson; David P De Souza; Woon Wai Keen; Eleanor C Saunders; Malcolm J McConville; Terence P Speed; Vladimir A Likić
A dynamic programming approach for the alignment of signal peaks in multiple gas chromatography-mass spectrometry experiments.
BMC bioinformatics 2007;8():419.
2006: Dale I Godfrey; Malcolm J McConville; Daniel G Pellicci
Chewing the fat on natural killer T cell development.
The Journal of experimental medicine 2006;203(10):2229-32.
2006: Phillip van der Peet; Carlie T Gannon; Ian Walker; Zoran Dinev; Marcus Angelin; Shanna Tam; Julie E Ralton; Malcolm J McConville; Spencer J Williams
Use of click chemistry to define the substrate specificity of Leishmania beta-1,2-mannosyltransferases.
Chembiochem : a European journal of chemical biology 2006;7(9):1384-91.
2006: Yasu S Morita; Chubert B C Sena; Ross F Waller; Ken Kurokawa; M Fleur Sernee; Fumiki Nakatani; Ruth E Haites; Helen Billman-Jacobe; Malcolm J McConville; Yusuke Maeda; Taroh Kinoshita
PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteria.
The Journal of biological chemistry 2006;281(35):25143-55.
2006: M Fleur Sernee; Julie E Ralton; Zoran Dinev; George N Khairallah; Richard A J O'Hair; Spencer J Williams; Malcolm J McConville
Leishmania beta-1,2-mannan is assembled on a mannose-cyclic phosphate primer.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(25):9458-63.
2006: David P De Souza; Eleanor C Saunders; Malcolm J McConville; Vladimir A Likić
Progressive peak clustering in GC-MS Metabolomic experiments applied to Leishmania parasites.
Bioinformatics (Oxford, England) 2006;22(11):1391-6.
2006: Svetozar Kovacevic; Dianne Anderson; Yasu S Morita; John Patterson; Ruth E Haites; Benjamin N I McMillan; Ross Coppel; Malcolm J McConville; Helen Billman-Jacobe
Identification of a novel protein with a role in lipoarabinomannan biosynthesis in mycobacteria.
The Journal of biological chemistry 2006;281(14):9011-7.
2006: Thomas Naderer; Miriam A Ellis; M Fleur Sernee; David P De Souza; Joan Curtis; Emanuela Handman; Malcolm J McConville
Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(14):5502-7.
2006: Paul R Gooley; Haydyn D T Mertens; Dedreia Tull; Malcolm J McConville
1H, 13C and 15N resonance assignments of SMP-1: a small myristoylated protein from Leishmania major.
Journal of biomolecular NMR 2006;36 Suppl 1():26.
2006: Rebecca E Miller; Malcolm J McConville; Ian E Woodrow
Cyanogenic glycosides from the rare Australian endemic rainforest tree Clerodendrum grayi (Lamiaceae).
Phytochemistry 2006;67(1):43-51.
2005: Paul R Sanders; Paul R Gilson; Greg T Cantin; Doron C Greenbaum; Thomas Nebl; Daniel J Carucci; Malcolm J McConville; Louis Schofield; Anthony N Hodder; John R Yates; Brendan S Crabb
Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum.
The Journal of biological chemistry 2005;280(48):40169-76.
2005: Yasu S Morita; René Velasquez; Ellen Taig; Ross F Waller; John H Patterson; Dedreia Tull; Spencer J Williams; Helen Billman-Jacobe; Malcolm J McConville
Compartmentalization of lipid biosynthesis in mycobacteria.
The Journal of biological chemistry 2005;280(22):21645-52.
2005: Ruth E Haites; Yasu S Morita; Malcolm J McConville; Helen Billman-Jacobe
Function of phosphatidylinositol in mycobacteria.
The Journal of biological chemistry 2005;280(12):10981-7.
2004: Dedreia Tull; James E Vince; judy callaghan; Thomas Naderer; Timothy P Spurck; Geoffrey I McFadden; Graeme Currie; Kris Ferguson; Antony Bacic; Malcolm J McConville
SMP-1, a member of a new family of small myristoylated proteins in kinetoplastid parasites, is targeted to the flagellum membrane in Leishmania.
Molecular biology of the cell 2004;15(11):4775-86.
2004: Dharshini Jeevarajah; John H Patterson; Ellen Taig; Tobias Sargeant; Malcolm J McConville; Helen Billman-Jacobe
Methylation of GPLs in Mycobacterium smegmatis and Mycobacterium avium.
Journal of bacteriology 2004;186(20):6792-9.
2004: Sumi Bandyopadhyay; Mitali Chatterjee; Santanu Pal; Ross F Waller; Shyam Sundar; Malcolm J McConville; Chitra Mandal
Purification, characterization of O-acetylated sialoglycoconjugates-specific IgM, and development of an enzyme-linked immunosorbent assay for diagnosis and follow-up of indian visceral leishmaniasis patients.
Diagnostic microbiology and infectious disease 2004;50(1):15-24.
2004: Thomas Naderer; James E Vince; Malcolm J McConville
Surface determinants of Leishmania parasites and their role in infectivity in the mammalian host.
Current molecular medicine 2004;4(6):649-65.
2004: Matthew A Dodge; Ross F Waller; Larry M C Chow; Muhammad M Zaman; Leanne M Cotton; Malcolm J McConville; Dyann F Wirth
Localization and activity of multidrug resistance protein 1 in the secretory pathway of Leishmania parasites.
Molecular microbiology 2004;51(6):1563-75.
2004: Yasu S Morita; John H Patterson; Helen Billman-Jacobe; Malcolm J McConville
Biosynthesis of mycobacterial phosphatidylinositol mannosides.
The Biochemical journal 2004;378(Pt 2):589-97.
2004: Ross F Waller; Malcolm J McConville; Geoffrey I McFadden
More plastids in human parasites?
Trends in parasitology 2004;20(2):54-7.
2003: Julie E Ralton; Thomas Naderer; Helena L Piraino; Tanya A Bashtannyk; judy callaghan; Malcolm J McConville
Evidence that intracellular beta1-2 mannan is a virulence factor in Leishmania parasites.
The Journal of biological chemistry 2003;278(42):40757-63.
2003: Michael J de Veer; Joan M Curtis; Tracey M Baldwin; Joseph A DiDonato; Adrienne Clare Sexton; Malcolm J McConville; Emanuela Handman; Louis Schofield
MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll-like receptor 2 signaling.
European journal of immunology 2003;33(10):2822-31.
2003: John H Patterson; Ross F Waller; Dharshini Jeevarajah; Helen Billman-Jacobe; Malcolm J McConville
Mannose metabolism is required for mycobacterial growth.
The Biochemical journal 2003;372(Pt 1):77-86.
2002: Bernardo J Foth; Aline Piani; Joan M Curtis; Thomas Ilg; Malcolm J McConville; Emanuela Handman
Leishmania major proteophosphoglycans exist as membrane-bound and soluble forms and localise to the cell membrane, the flagellar pocket and the lysosome.
International journal for parasitology 2002;32(14):1701-8.
2002: Thomas Naderer; Malcolm J McConville
Characterization of a Leishmania mexicana mutant defective in synthesis of free and protein-linked GPI glycolipids.
Molecular and biochemical parasitology 2002;125(1-2):147-61.
2002: Ross F Waller; Malcolm J McConville
Developmental changes in lysosome morphology and function Leishmania parasites.
International journal for parasitology 2002;32(12):1435-45.
2002: Dharshini Jeevarajah; John H Patterson; Malcolm J McConville; Helen Billman-Jacobe
Modification of glycopeptidolipids by an O-methyltransferase of Mycobacterium smegmatis.
Microbiology (Reading, England) 2002;148(Pt 10):3079-87.
2002: Malcolm J McConville; Steven C Ilgoutz; Rohan Teasdale; Bernardo J Foth; Antony Matthews; Kylie A Mullin; Paul A Gleeson
Targeting of the GRIP domain to the trans-Golgi network is conserved from protists to animals.
European journal of cell biology 2002;81(9):485-95.
2002: Julie E Ralton; Kylie A Mullin; Malcolm J McConville
Intracellular trafficking of glycosylphosphatidylinositol (GPI)-anchored proteins and free GPIs in Leishmania mexicana.
The Biochemical journal 2002;363(Pt 2):365-75.
2002: Malcolm J McConville; Kylie A Mullin; Steven C Ilgoutz; Rohan Teasdale
Secretory pathway of trypanosomatid parasites.
Microbiology and molecular biology reviews : MMBR 2002;66(1):122-54; table of contents.
2001: Kylie A Mullin; Bernardo J Foth; Steven C Ilgoutz; judy callaghan; JL Zawadzki; Geoffrey I McFadden; Malcolm J McConville
Regulated degradation of an endoplasmic reticulum membrane protein in a tubular lysosome in Leishmania mexicana.
Molecular biology of the cell 2001;12(8):2364-77.
2001: Steven C Ilgoutz; Malcolm J McConville
Function and assembly of the Leishmania surface coat.
International journal for parasitology 2001;31(9):899-908.
2000: John H Patterson; Malcolm J McConville; Ruth E Haites; Ross Coppel; Helen Billman-Jacobe
Identification of a methyltransferase from Mycobacterium smegmatis involved in glycopeptidolipid synthesis.
The Journal of biological chemistry 2000;275(32):24900-6.
2000: James D Hilley; JL Zawadzki; Malcolm J McConville; Graham H Coombs; Jeremy C Mottram
Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI):protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins.
Molecular biology of the cell 2000;11(4):1183-95.
2000: S Moody-Haupt; John H Patterson; David Mirelman; Malcolm J McConville
The major surface antigens of Entamoeba histolytica trophozoites are GPI-anchored proteophosphoglycans.
Journal of molecular biology 2000;297(2):409-20.
2000: Malcolm J McConville; A K Menon
Recent developments in the cell biology and biochemistry of glycosylphosphatidylinositol lipids (review).
Molecular membrane biology 2000;17(1):1-16.
1999: Helen Billman-Jacobe; Malcolm J McConville; Ruth E Haites; Svetozar Kovacevic; Ross Coppel
Identification of a peptide synthetase involved in the biosynthesis of glycopeptidolipids of Mycobacterium smegmatis.
Molecular microbiology 1999;33(6):1244-53.
1999: Steven C Ilgoutz; Kylie A Mullin; Bridget R Southwell; Malcolm J McConville
Glycosylphosphatidylinositol biosynthetic enzymes are localized to a stable tubular subcompartment of the endoplasmic reticulum in Leishmania mexicana.
The EMBO journal 1999;18(13):3643-54.
1999: Steven C Ilgoutz; JL Zawadzki; Julie E Ralton; Malcolm J McConville
Evidence that free GPI glycolipids are essential for growth of Leishmania mexicana.
The EMBO journal 1999;18(10):2746-55.
1999: JM Moss; Gavin E Reid; Kylie A Mullin; JL Zawadzki; R J Simpson; Malcolm J McConville
Characterization of a novel GDP-mannose:Serine-protein mannose-1-phosphotransferase from Leishmania mexicana.
The Journal of biological chemistry 1999;274(10):6678-88.
1998: JL Zawadzki; C Scholz; Graeme Currie; Graham H Coombs; Malcolm J McConville
The glycoinositolphospholipids from Leishmania panamensis contain unusual glycan and lipid moieties.
Journal of molecular biology 1998;282(2):287-99.
1998: Julie E Ralton; Malcolm J McConville
Delineation of three pathways of glycosylphosphatidylinositol biosynthesis in Leishmania mexicana. Precursors from different pathways are assembled on distinct pools of phosphatidylinositol and undergo fatty acid remodeling.
The Journal of biological chemistry 1998;273(7):4245-57.
1997: Malcolm J McConville; Julie E Ralton
Developmentally regulated changes in the cell surface architecture of Leishmania parasites.
Behring Institute Mitteilungen 1997;(99):34-43.
1997: S Moody; S Becker; Yael Nuchamowitz; Malcolm J McConville; David Mirelman
The lipophosphoglycan-like molecules of virulent and avirulent E. histolytica as well as of E. dispar differ in both composition and abundance.
Archives of medical research 1997;28 Spec No():98-102.
1996: SD Tachado; Peter Gerold; Malcolm J McConville; T Baldwin; D Quilici; Ralph T Schwarz; Louis Schofield
Glycosylphosphatidylinositol toxin of Plasmodium induces nitric oxide synthase expression in macrophages and vascular endothelial cells by a protein tyrosine kinase-dependent and protein kinase C-dependent signaling pathway.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(5):1897-1907.
1996: Louis Schofield; S Novakovic; Peter Gerold; Ralph T Schwarz; Malcolm J McConville; SD Tachado
Glycosylphosphatidylinositol toxin of Plasmodium up-regulates intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin expression in vascular endothelial cells and increases leukocyte and parasite cytoadherence via tyrosine kinase-dependent signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(5):1886-96.
1996: P Schneider; Achim Treumann; Kenneth G Milne; Malcolm J McConville; Nicole Zitzmann; Michael A J Ferguson
Structural studies on a lipoarabinogalactan of Crithidia fasciculata.
The Biochemical journal 1996;313 ( Pt 3)():963-71.
1995: Malcolm J McConville
The surface glycoconjugates of parasitic protozoa: potential targets for new drugs.
Australian and New Zealand journal of medicine 1995;25(6):768-76.
1995: Malcolm J McConville; L F Schnur; C Jaffe; P Schneider
Structure of Leishmania lipophosphoglycan: inter- and intra-specific polymorphism in Old World species.
The Biochemical journal 1995;310 ( Pt 3)():807-18.
1995: L Proudfoot; P Schneider; Michael A J Ferguson; Malcolm J McConville
Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major.
The Biochemical journal 1995;308 ( Pt 1)():45-55.
1994: P Schneider; L F Schnur; Charles L Jaffe; Michael A J Ferguson; Malcolm J McConville
Glycoinositol-phospholipid profiles of four serotypically distinct Old World Leishmania strains.
The Biochemical journal 1994;304 ( Pt 2)():603-9.
1994: C T Weller; Malcolm J McConville; Steve W Homans
Solution structure and dynamics of a glycoinositol phospholipid (GIPL-6) from Leishmania major.
Biopolymers 1994;34(9):1155-63.
1994: P Schneider; Malcolm J McConville; Michael A J Ferguson
Characterization of GDP-alpha-D-arabinopyranose, the precursor of D-Arap in Leishmania major lipophosphoglycan.
The Journal of biological chemistry 1994;269(28):18332-7.
1994: Malcolm J McConville; P Schneider; L Proudfoot; C Masterson; Michael A J Ferguson
The developmental regulation and biosynthesis of GPI-related structures in Leishmania parasites.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1994;27(2):139-44.
1994: Michael A J Ferguson; John S Brimacombe; S Cottaz; Robert A Field; L S Güther; Steve W Homans; Malcolm J McConville; Angela Mehlert; Kenneth G Milne; Julie E Ralton
Glycosyl-phosphatidylinositol molecules of the parasite and the host.
Parasitology 1994;108 Suppl():S45-54.
1993: C Fankhauser; Steve W Homans; J E Thomas-Oates; Malcolm J McConville; Chantal Desponds; Andreas Conzelmann; Michael A J Ferguson
Structures of glycosylphosphatidylinositol membrane anchors from Saccharomyces cerevisiae.
The Journal of biological chemistry 1993;268(35):26365-74.
1993: P Schneider; J P Rosat; A Ransijn; Michael A J Ferguson; Malcolm J McConville
Characterization of glycoinositol phospholipids in the amastigote stage of the protozoan parasite Leishmania major.
The Biochemical journal 1993;295 ( Pt 2)():555-64.
1993: S F Moody; Emanuela Handman; Malcolm J McConville; Antony Bacic
The structure of Leishmania major amastigote lipophosphoglycan.
The Journal of biological chemistry 1993;268(25):18457-66.
1993: Malcolm J McConville; Michael A J Ferguson
The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes.
The Biochemical journal 1993;294 ( Pt 2)():305-24.
1993: Malcolm J McConville; T A Collidge; Michael A J Ferguson; P Schneider
The glycoinositol phospholipids of Leishmania mexicana promastigotes. Evidence for the presence of three distinct pathways of glycolipid biosynthesis.
The Journal of biological chemistry 1993;268(21):15595-604.
1993: P Schneider; Julie E Ralton; Malcolm J McConville; Michael A J Ferguson
Analysis of the neutral glycan fractions of glycosyl-phosphatidylinositols by thin-layer chromatography.
Analytical biochemistry 1993;210(1):106-12.
1993: Michael A J Ferguson; P Murray; H Rutherford; Malcolm J McConville
A simple purification of procyclic acidic repetitive protein and demonstration of a sialylated glycosyl-phosphatidylinositol membrane anchor.
The Biochemical journal 1993;291 ( Pt 1)():51-5.
1993: M J Elhay; Malcolm J McConville; Joan M Curtis; Antony Bacic; Emanuela Handman
Identification of truncated forms of lipophosphoglycan in mutant cloned lines of Leishmania major that are deficient in mature lipophosphoglycan.
Parasitology research 1993;79(5):435-8.
1992: Malcolm J McConville; S J Turco; Michael A J Ferguson; D L Sacks
Developmental modification of lipophosphoglycan during the differentiation of Leishmania major promastigotes to an infectious stage.
The EMBO journal 1992;11(10):3593-600.
1992: J R Thomas; Malcolm J McConville; J E Thomas-Oates; Steve W Homans; Michael A J Ferguson; P A Gorin; K D Greis; S J Turco
Refined structure of the lipophosphoglycan of Leishmania donovani.
The Journal of biological chemistry 1992;267(10):6829-33.
1992: K D Greis; Salvatore J Turco; J R Thomas; Malcolm J McConville; Steve W Homans; M A Ferguson
Purification and characterization of an extracellular phosphoglycan from Leishmania donovani.
The Journal of biological chemistry 1992;267(9):5876-81.
1992: Malcolm J McConville; Steve W Homans
Identification of the defect in lipophosphoglycan biosynthesis in a non-pathogenic strain of Leishmania major.
The Journal of biological chemistry 1992;267(9):5855-61.
1991: Michael A J Ferguson; W J Masterson; Steve W Homans; Malcolm J McConville
Evolutionary aspects of GPI metabolism in kinetoplastid parasites.
Cell biology international reports 1991;15(11):991-1005.
1991: Malcolm J McConville
Glycosylated-phosphatidylinositols as virulence factors in Leishmania.
Cell biology international reports 1991;15(9):779-98.
1991: Malcolm J McConville; J M Blackwell
Developmental changes in the glycosylated phosphatidylinositols of Leishmania donovani. Characterization of the promastigote and amastigote glycolipids.
The Journal of biological chemistry 1991;266(23):15170-9.
1990: Malcolm J McConville; J E Thomas-Oates; Michael A J Ferguson; Steve W Homans
Structure of the lipophosphoglycan from Leishmania major.
The Journal of biological chemistry 1990;265(32):19611-23.
1990: Pascal Schneider; Michael A J Ferguson; Malcolm J McConville; Angela Mehlert; Steve W Homans; C Bordier
Structure of the glycosyl-phosphatidylinositol membrane anchor of the Leishmania major promastigote surface protease.
The Journal of biological chemistry 1990;265(28):16955-64.
1990: Malcolm J McConville; Steve W Homans; J E Thomas-Oates; A Dell; Antony Bacic
Structures of the glycoinositolphospholipids from Leishmania major. A family of novel galactofuranose-containing glycolipids.
The Journal of biological chemistry 1990;265(13):7385-94.
1990: M Elhay; M Kelleher; Antony Bacic; Malcolm J McConville; D L Tolson; Terry W Pearson; Emanuela Handman
Lipophosphoglycan expression and virulence in ricin-resistant variants of Leishmania major.
Molecular and biochemical parasitology 1990;40(2):255-67.
1990: Malcolm J McConville; Antony Bacic
The glycoinositolphospholipid profiles of two Leishmania major strains that differ in lipophosphoglycan expression.
Molecular and biochemical parasitology 1990;38(1):57-67.
1989: Malcolm J McConville; Antony Bacic
A family of glycoinositol phospholipids from Leishmania major. Isolation, characterization, and antigenicity.
The Journal of biological chemistry 1989;264(2):757-66.
1988: M J Elhay; Malcolm J McConville; Emanuela Handman
Immunochemical characterization of a glyco-inositol-phospholipid membrane antigen of Leishmania major.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(4):1326-31.
1987: Malcolm J McConville; Antony Bacic; G F Mitchell; Emanuela Handman
Lipophosphoglycan of Leishmania major that vaccinates against cutaneous leishmaniasis contains an alkylglycerophosphoinositol lipid anchor.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):8941-5.
1987: G F Mitchell; Emanuela Handman; H Moll; Malcolm J McConville; Terry W Spithill; G Z Kidane; N Samaras; M J Elhay
Resistance and susceptibility of mice to Leishmania major: a view from Melbourne.
Annales de l'Institut Pasteur. Immunology 1987;138(5):738-43.