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Frank McCormick

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Amy Young; David Lou; Frank McCormick
Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling.
Irma B Stowe; Timothy R Stowe; Ellen L Mercado; Juan A Oses-Prieto; Erika L Bell; Alma L Burlingame; Hilda Hernández; Frank McCormick
A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1.
Katherine A Rauen; Anuradha Banerjee; W Robert Bishop; Jennifer O Lauchle; Frank McCormick; Martin McMahon; Teri Melese; Pamela N Munster; Sorena Nadaf; Roger J Packer; Judith Leopold; David H Viskochil
Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies.

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All Publications

2013: Amy Young; David Lou; Frank McCormick
Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling.
Cancer discovery 2013;3(1):112-23.
2012: Irma B Stowe; Timothy R Stowe; Ellen L Mercado; Juan A Oses-Prieto; Erika L Bell; Alma L Burlingame; Hilda Hernández; Frank McCormick
A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1.
Genes & development 2012;26(13):1421-6.
2011: Katherine A Rauen; Anuradha Banerjee; W Robert Bishop; Jennifer O Lauchle; Frank McCormick; Martin McMahon; Teri Melese; Pamela N Munster; Sorena Nadaf; Roger J Packer; Judith Leopold; David H Viskochil
Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies.
American journal of medical genetics. Part C, Seminars in medical genetics 2011;157(2):136-46.
2011: Frank McCormick
Cancer therapy based on oncogene addiction.
Journal of surgical oncology 2011;103(6):464-7.
2011: Stephan Gysin; Megan Salt; Amy Young; Frank McCormick
Therapeutic strategies for targeting ras proteins.
Genes & cancer 2011;2(3):359-72.
2011: Frank McCormick
Mutant onco-proteins as drug targets: successes, failures, and future prospects.
Current opinion in genetics & development 2011;21(1):29-33.
2010: Seiko Ishida; Frank McCormick; Karen Smith-McCune; Douglas Hanahan
Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator.
Cancer cell 2010;17(6):574-83.
2010: Vernon T Phan; Vivianne W Ding; Fenglei Li; Robert J Chalkley; Alma Burlingame; Frank McCormick
The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans.
Molecular and cellular biology 2010;30(9):2264-79.
2010: Frank McCormick
How blocking Raf activates the MAPK pathway.
Pigment cell & melanoma research 2010;23(2):187-9.
2010: Cynthia Lyle; Frank McCormick
Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells.
Virology journal 2010;7():148.
2009: Olga K Mirzoeva; Debopriya Das; Laura M Heiser; Sanchita Bhattacharya; Doris Siwak; Rina Gendelman; Nora Bayani; Nicholas J Wang; Richard M Neve; Yinghui Guan; Zhi Hu; Zachary A Knight; Heidi S Feiler; Philippe Gascard; Bahram Parvin; Paul Spellman; Kevan M Shokat; Andrew J Wyrobek; Mina J Bissell; Frank McCormick; Wen-Lin Kuo; Gordon B Mills; Joe Gray; W Michael Korn
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition.
Cancer research 2009;69(2):565-72.
2009: Qi-Wen Fan; Christine Cheng; Zachary A Knight; Daphne A Haas-Kogan; David Stokoe; C David James; Frank McCormick; Kevan M Shokat; William A Weiss
EGFR signals to mTOR through PKC and independently of Akt in glioma.
Science signaling 2009;2(55):ra4.
2008: Sang Hyun Lee; Harry Sterling; Alma Burlingame; Frank McCormick
Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint.
Genes & development 2008;22(21):2926-31.
2008: Katsutoshi Oda; Jennifer Okada; Luika Timmerman; Pablo Rodriguez-Viciana; David Stokoe; Keiko Shoji; Yuji Taketani; Hiroyuki Kuramoto; Zachary A Knight; Kevan M Shokat; Frank McCormick
PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation.
Cancer research 2008;68(19):8127-36.
2008: Katherine A Rauen; Erin Hefner; Kristin Carrillo; Jill Taylor; Laure Messier; Yoko Aoki; Karen W Gripp; Yoichi Matsubara; Virginia K Proud; Peter Hammond; Judith E Allanson; Marie-Ange Delrue; Marni E Axelrad; Angela E Lin; Daniel A Doyle; Bronwyn Kerr; John C Carey; Frank McCormick; Alcino J Silva; Mark W Kieran; Aleksander Hinek; Tan T Nguyen; Lisa Schoyer
Molecular aspects, clinical aspects and possible treatment modalities for Costello syndrome: Proceedings from the 1st International Costello Syndrome Research Symposium 2007.
American journal of medical genetics. Part A 2008;146A(9):1205-17.
2008: Mayumi Kitagawa; Sang Hyun Lee; Frank McCormick
Skp2 suppresses p53-dependent apoptosis by inhibiting p300.
Molecular cell 2008;29(2):217-31.
2008: Thanaset Senawong; Janyaporn Phuchareon; Osamu Ohara; Frank McCormick; Katherine A Rauen; Osamu Tetsu
Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options.
Human molecular genetics 2008;17(3):419-30.
2007: Demetris C Iacovides; Clodagh C. O'Shea; Juan Oses-Prieto; Al L Burlingame; Frank McCormick
Critical role for arginine methylation in adenovirus-infected cells.
Journal of virology 2007;81(23):13209-17.
2007: Anne L Estep; Chana Palmer; Frank McCormick; Katherine A Rauen
Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy.
PloS one 2007;2(12):e1279.
2006: Richard M Neve; Koei Chin; Jane Fridlyand; Jennifer Yeh; Frederick L Baehner; Tea Fevr; Laura Clark; Nora Bayani; Jean-Philippe Coppe; Frances Tong; Terence P Speed; Paul Spellman; Sandy Devries; Anna Lapuk; Nick J Wang; Wen-Lin Kuo; Jackie L Stilwell; Daniel Pinkel; Donna G Albertson; Frederic M Waldman; Frank McCormick; Robert B Dickson; Michael D Johnson; Marc Lippman; Stephen Ethier; Adi F Gazdar; Joe Gray
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Cancer cell 2006;10(6):515-27.
2006: Sang Hyun Lee; Frank McCormick
p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins.
The EMBO journal 2006;25(17):4008-19.
2006: Pablo Rodriguez-Viciana; Juan Oses-Prieto; Al L Burlingame; Mike Fried; Frank McCormick
A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.
Molecular cell 2006;22(2):217-30.
2006: Pablo Rodriguez-Viciana; Frank McCormick
Ras ubiquitination: coupling spatial sorting and signal transmission.
Cancer cell 2006;9(4):243-4.
2006: Pablo Rodriguez-Viciana; Osamu Tetsu; William E Tidyman; Anne L Estep; Brenda A Conger; Molly Santa Cruz; Frank McCormick; Katherine A Rauen
Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome.
Science (New York, N.Y.) 2006;311(5765):1287-90.
2006: Hiroshi Okabe; Sang-Hyun Lee; Janyaporn Phuchareon; Donna G Albertson; Frank McCormick; Osamu Tetsu
A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation.
PloS one 2006;1():e128.
2006: Pablo Rodriguez-Viciana; Frank McCormick
Characterization of interactions between ras family GTPases and their effectors.
Methods in enzymology 2006;407():187-94.
2006: Liang You; Jae Kim; Biao He; Zhidong Xu; Frank McCormick; David M Jablons
Wnt-1 signal as a potential cancer therapeutic target.
Drug news & perspectives 2006;19(1):27-31.
2005: Katsutoshi Oda; David Stokoe; Yuji Taketani; Frank McCormick
High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma.
Cancer research 2005;65(23):10669-73.
2005: Julien Mazieres; Liang You; Biao He; Zhidong Xu; Amie Y Lee; Iwao Mikami; Frank McCormick; David M Jablons
Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis.
Oncogene 2005;24(34):5396-400.
2005: Madhu Macrae; Richard M Neve; Pablo Rodriguez-Viciana; Christopher Haqq; Jennifer Yeh; Chira Chen; Joe Gray; Frank McCormick
A conditional feedback loop regulates Ras activity through EphA2.
Cancer cell 2005;8(2):111-8.
2005: Clodagh C. O'Shea; Conrado Soria; Bridget Bagus; Frank McCormick
Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy.
Cancer cell 2005;8(1):61-74.
2005: Clodagh C. O'Shea; Serah Choi; Frank McCormick; David Stokoe
Adenovirus overrides cellular checkpoints for protein translation.
Cell cycle (Georgetown, Tex.) 2005;4(7):883-8.
2005: Biao He; Noemi Reguart; Liang You; Julien Mazieres; Zhidong Xu; Amie Y Lee; Iwao Mikami; Frank McCormick; David M Jablons
Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations.
Oncogene 2005;24(18):3054-8.
2005: Sang Hyun Lee; Frank McCormick
Downregulation of Skp2 and p27/Kip1 synergistically induces apoptosis in T98G glioblastoma cells.
Journal of molecular medicine (Berlin, Germany) 2005;83(4):296-307.
2005: Clodagh C. O'Shea; Kristina Klupsch; Serah Choi; Bridget Bagus; Conrado Soria; Jerry Shen; Frank McCormick; David Stokoe
Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication.
The EMBO journal 2005;24(6):1211-21.
2005: Pablo Rodriguez-Viciana; Frank McCormick
RalGDS comes of age.
Cancer cell 2005;7(3):205-6.
2005: Biao He; Amie Y Lee; Sina Dadfarmay; Liang You; Zhidong Xu; Noemi Reguart; Julien Mazieres; Iwao Mikami; Frank McCormick; David M Jablons
Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells.
Cancer research 2005;65(3):743-8.
2005: Christian H Brandts; Benoit Bilanges; Gregor Hare; Frank McCormick; David Stokoe
Phosphorylation-independent stabilization of p27kip1 by the phosphoinositide 3-kinase pathway in glioblastoma cells.
The Journal of biological chemistry 2005;280(3):2012-9.
2005: Pablo Rodriguez-Viciana; Osamu Tetsu; K Oda; J Okada; Katherine A Rauen; Frank McCormick
Cancer targets in the Ras pathway.
Cold Spring Harbor symposia on quantitative biology 2005;70():461-7.
2004: Clodagh C. O'Shea; Leisa Johnson; Bridget Bagus; Serah Choi; Cory Nicholas; Arthur Shen; Larry Boyle; Kusum Pandey; Conrado Soria; John Kunich; Yuqiao Shen; Gaston Habets; David Ginzinger; Frank McCormick
Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity.
Cancer cell 2004;6(6):611-23.
2004: Noemi Reguart; Biao He; Zhidong Xu; Liang You; Amie Y Lee; Julien Mazieres; Iwao Mikami; Sonny Batra; Rafael Rosell; Frank McCormick; David M Jablons
Cloning and characterization of the promoter of human Wnt inhibitory factor-1.
Biochemical and biophysical research communications 2004;323(1):229-34.
2004: Amie Y Lee; Biao He; Liang You; Sina Dadfarmay; Zhidong Xu; Julien Mazieres; Iwao Mikami; Frank McCormick; David M Jablons
Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma.
Oncogene 2004;23(39):6672-6.
2004: Liang You; Biao He; Zhidong Xu; Kazutsugu Uematsu; Julien Mazieres; Iwao Mikami; Noemi Reguart; Terry W Moody; Jan Kitajewski; Frank McCormick; David M Jablons
Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells.
Oncogene 2004;23(36):6170-4.
2004: Liang You; Biao He; Zhidong Xu; Kazutsugu Uematsu; Julien Mazieres; Naoaki Fujii; Iwao Mikami; Noemi Reguart; Joe K McIntosh; Mohammed Kashani-Sabet; Frank McCormick; David M Jablons
An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth.
Cancer research 2004;64(15):5385-9.
2004: Julien Mazieres; Biao He; Liang You; Zhidong Xu; Amie Y Lee; Iwao Mikami; Noemi Reguart; Rafael Rosell; Frank McCormick; David M Jablons
Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer.
Cancer research 2004;64(14):4717-20.
2004: Pablo Rodriguez-Viciana; Celine Sabatier; Frank McCormick
Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate.
Molecular and cellular biology 2004;24(11):4943-54.
2004: Liang You; Biao He; Kazutsugu Uematsu; Zhidong Xu; Julien Mazieres; Amie Lee; Frank McCormick; David M Jablons
Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells.
Cancer research 2004;64(10):3474-8.
2004: Biao He; Liang You; Kazutsugu Uematsu; Zhidong Xu; Amie Y Lee; Maria Matsangou; Frank McCormick; David M Jablons
A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells.
Neoplasia (New York, N.Y.) 2004;6(1):7-14.
2004: Liang You; Biao He; Zhidong Xu; Frank McCormick; David M Jablons
Future directions: oncolytic viruses.
Clinical lung cancer 2004;5(4):226-30.
2003: Biao He; Liang You; Kazutsugu Uematsu; Keling Zang; Zhidong Xu; Amie Y Lee; Joseph F Costello; Frank McCormick; David M Jablons
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14133-8.
2003: Donna G Albertson; Colin Collins; Frank McCormick; Joe Gray
Chromosome aberrations in solid tumors.
Nature genetics 2003;34(4):369-76.
2003: Mario Anders; Christine Christian; Martin McMahon; Frank McCormick; W Michael Korn
Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells.
Cancer research 2003;63(9):2088-95.
2003: Osamu Tetsu; Frank McCormick
Proliferation of cancer cells despite CDK2 inhibition.
Cancer cell 2003;3(3):233-45.
2003: Jay Gump; David Stokoe; Frank McCormick
Phosphorylation of p16INK4A correlates with Cdk4 association.
The Journal of biological chemistry 2003;278(9):6619-22.
2002: Chunyao Xia; Zhidong Xu; Xiaocheng Yuan; Kazutsugu Uematsu; Liang You; Kai Li; Li Li; Frank McCormick; David M Jablons
Induction of apoptosis in mesothelioma cells by antisurvivin oligonucleotides.
Molecular cancer therapeutics 2002;1(9):687-94.
2002: Katherine A Rauen; Daniel Sudilovsky; Jason L Le; Karen L Chew; Byron Hann; Vivian Weinberg; Lars Schmitt; Frank McCormick
Expression of the coxsackie adenovirus receptor in normal prostate and in primary and metastatic prostate carcinoma: potential relevance to gene therapy.
Cancer research 2002;62(13):3812-8.
2002: Leisa Johnson; Arthur Shen; Larry Boyle; John Kunich; Kusum Pandey; Marilyn Lemmon; Terry W Hermiston; Marty Giedlin; Frank McCormick; Ali Fattaey
Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents.
Cancer cell 2002;1(4):325-37.
2002: Carola Biederer; Stefan Ries; Christian H Brandts; Frank McCormick
Replication-selective viruses for cancer therapy.
Journal of molecular medicine (Berlin, Germany) 2002;80(3):163-75.
2001: K Wakita; Frank McCormick; Osamu Tetsu
Method for screening ecdysone-inducible stable cell lines.
BioTechniques 2001;31(2):414-8.
2001: J Xie; Michelle Aszterbaum; Xinjiang Zhang; Jeannette Bonifas; CB Zachary; E Epstein; Frank McCormick
A role of PDGFRalpha in basal cell carcinoma proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9255-9.
2001: R H Chen; Frank McCormick
Selective targeting to the hyperactive beta-catenin/T-cell factor pathway in colon cancer cells.
Cancer research 2001;61(11):4445-9.
2001: Garret Yount; Golnar Afshar; Stefan Ries; M Korn; Noga Shalev; Daniel Basila; Frank McCormick; Daphne A Haas-Kogan
Transcriptional activation of TRADD mediates p53-independent radiation-induced apoptosis of glioma cells.
Oncogene 2001;20(22):2826-35.
2001: J W Park; Frank McCormick
ErbB receptors and Ras: upstream, downstream?
Cancer journal (Sudbury, Mass.) 2001;7(3):178-80.
2001: K Wakita; Osamu Tetsu; Frank McCormick
A mammalian two-hybrid system for adenomatous polyposis coli-mutated colon cancer therapeutics.
Cancer research 2001;61(3):854-8.
2000: V W Ding; RH Chen; Frank McCormick
Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling.
The Journal of biological chemistry 2000;275(42):32475-81.
2000: Stefan Ries; Carola Biederer; D Woods; O Shifman; S Shirasawa; T Sasazuki; Martin McMahon; M Oren; Frank McCormick
Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.
Cell 2000;103(2):321-30.
2000: Stefan Ries; C H Brandts; Alicia Chung; Carola Biederer; B C Hann; E M Lipner; Frank McCormick; W Michael Korn
Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).
Nature medicine 2000;6(10):1128-33.
2000: Carola Biederer; Stefan Ries; M Moser; M Florio; Mark Israel; Frank McCormick; R Buettner
The basic helix-loop-helix transcription factors myogenin and Id2 mediate specific induction of caveolin-3 gene expression during embryonic development.
The Journal of biological chemistry 2000;275(34):26245-51.
2000: A M Crompton; L H Foley; A Wood; W Roscoe; David Stokoe; Frank McCormick; Marc Symons; Gideon Bollag
Regulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligands.
The Journal of biological chemistry 2000;275(33):25751-9.
2000: RH Chen; W V Ding; Frank McCormick
Wnt signaling to beta-catenin involves two interactive components. Glycogen synthase kinase-3beta inhibition and activation of protein kinase C.
The Journal of biological chemistry 2000;275(23):17894-9.
2000: C T Yang; Liang You; C C Yeh; J W Chang; F Zhang; Frank McCormick; David M Jablons
Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells.
Journal of the National Cancer Institute 2000;92(8):636-41.
2000: T Tominaga; E Sahai; P Chardin; Frank McCormick; S A Courtneidge; ARTHUR S ALBERTS
Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling.
Molecular cell 2000;5(1):13-25.
1999: P Sabbatini; Frank McCormick
Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis.
The Journal of biological chemistry 1999;274(34):24263-9.
1999: P Chardin; Frank McCormick
Brefeldin A: the advantage of being uncompetitive.
Cell 1999;97(2):153-5.
1999: Osamu Tetsu; Frank McCormick
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.
Nature 1999;398(6726):422-6.