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James McCubrey

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William H Chappell; Francesca Chiarini; Lucio Cocco; Camilla Evangelisti; Richard A Franklin; Michelle M LaHair; Alberto M Martelli; Kristin M Stadelman; Linda S Steelman; Steven L Abrams; James A McCubrey
Increased NGAL (Lnc2) expression after chemotherapeutic drug treatment.
Matilde Y Follo; Pietro Gobbi; Francesco A Manzoli; Sandra Marmiroli; Alberto M Martelli; James A McCubrey; Giulia Ramazzotti; Irene Faenza; Carlo Finelli; Roberta Fiume; Lucio Cocco
Nuclear phospholipase C β1 signaling, epigenetics and treatments in MDS.
J Dulinska-Litewka; James A McCubrey; P Laidler
Increased Akt signaling resulting from the loss of androgen responsiveness in prostate cancer.

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All Publications

2013: William H Chappell; Francesca Chiarini; Lucio Cocco; Camilla Evangelisti; Richard A Franklin; Michelle M LaHair; Alberto M Martelli; Kristin M Stadelman; Linda S Steelman; Steven L Abrams; James A McCubrey
Increased NGAL (Lnc2) expression after chemotherapeutic drug treatment.
Advances in biological regulation 2013;53(1):146-55.
2013: Matilde Y Follo; Pietro Gobbi; Francesco A Manzoli; Sandra Marmiroli; Alberto M Martelli; James A McCubrey; Giulia Ramazzotti; Irene Faenza; Carlo Finelli; Roberta Fiume; Lucio Cocco
Nuclear phospholipase C β1 signaling, epigenetics and treatments in MDS.
Advances in biological regulation 2013;53(1):2-7.
2013: J Dulinska-Litewka; James A McCubrey; P Laidler
Increased Akt signaling resulting from the loss of androgen responsiveness in prostate cancer.
Current medicinal chemistry 2013;20(1):144-57.
2013: Paolo Fagone; Massimo Libra; Santa Mammana; Katia Mangano; James A McCubrey; Marinella Coco; Marco Donia; cinzia quattrocchi; Ferdinando Nicoletti
Comparative study of rapamycin and temsirolimus demonstrates superimposable anti-tumour potency on prostate cancer cells.
Basic & clinical pharmacology & toxicology 2013;112(1):63-9.
2012: William H Chappell; Brian D Lehmann; Linda Steelman; David M Terrian; Steven L Abrams; James A McCubrey
p53 expression controls prostate cancer sensitivity to chemotherapy and the MDM2 inhibitor Nutlin-3.
Cell cycle (Georgetown, Tex.) 2012;11(24):4579-88.
2012: Albert E Berman; Zoya N Demidenko; Olga V Leontieva; James A McCubrey; Venkatesh Natarajan; Mikhail A Nikiforov
Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes.
Oncotarget 2012;3(12):1522-32.
2012: Francesca Chiarini; Mirella Falconi; Ilaria Iacobucci; Annalisa Lonetti; Sergio Amadori; Daniela Bressanin; Alessandra Cappellini; Giovanni Martinelli; James A McCubrey; Andrea Ognibene; Ester Orsini; Pasqualepaolo Pagliaro; Francesca Ricci; Pier Luigi Tazzari; Gabriella Teti; Alberto M Martelli
A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia.
Oncotarget 2012;3(12):1615-28.
2012: William H Chappell; Richard A Franklin; Michelle M LaHair; Massimo Libra; Alberto M Martelli; Michele Milella; Giuseppe Montalto; Ferdinando Nicoletti; Jerry Polesel; Linda Steelman; Agostino Tafuri; Renato Talamini; Steven L Abrams; Saverio Candido; Melchiorre Cervello; James A McCubrey
Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine.
Cell cycle (Georgetown, Tex.) 2012;11(23):4447-61.
2012: C Simioni; Giovanna Tabellini; Pier Luigi Tazzari; D Bressanin; A Cani; S Capitani; Francesca Chiarini; Camilla Evangelisti; James A McCubrey; Fraia Melchionda; Luca M Neri; P Pagliaro; A Pession; Francesca Ricci; Alberto M Martelli
Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia.
Leukemia 2012;26(11):2336-42.
2012: William H Chappell; Massimo Libra; Alberto M Martelli; Steven L Abrams; Ralph Arlinghaus; Saverio Candido; Melchiorre Cervello; Giuseppe Montalto; Jerry Polesel; Linda Steelman; Renato Talamini; James A McCubrey
Effects of ectopic expression of NGAL on doxorubicin sensitivity.
Oncotarget 2012;3(10):1236-45.
2012: James A McCubrey; Sanja Mijatovic; Michele Milella; Giuseppe Montalto; Ferdinando Nicoletti; Linda Steelman; Agostino Tafuri; Maria Clorinda Mazzarino; Steven L Abrams; Jörg Bäsecke; Saverio Candido; Melchiorre Cervello; William H Chappell; Francesca Chiarini; Lucio Cocco; Camilla Evangelisti; Paolo Fagone; Richard A Franklin; Massimo Libra; Danijela Maksimovic-Ivanic; Grazia Malaponte; Alberto M Martelli
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.
Oncotarget 2012;3(10):1068-111.
2012: Giulia Costanza Leonardi; James A McCubrey; Fabio Raiti; Saverio Candido; Maurizio Carbone; Diana Cinà; Valeria Colaianni; Sebastiano Garozzo; Massimo Libra
BRAF mutations in papillary thyroid carcinoma and emerging targeted therapies (review).
Molecular medicine reports 2012;6(4):687-94.
2012: Marija Mojic; Marija Stankovic; Stanislava Stosic-Grujicic; Salvatore Travali; Mai-Britt Zocca; Yousef Al-Abed; Marco Donia; Paolo Fagone; Danijela Maksimovic-Ivanic; Katia Mangano; James A McCubrey; Sanja Mijatovic; Djordje Miljkovic; Ferdinando Nicoletti
Therapeutic potential of nitric oxide-modified drugs in colon cancer cells.
Molecular pharmacology 2012;82(4):700-10.
2012: Maria Rosaria Ricciardi; Maria Cristina Scerpa; Linda S Steelman; Agostino Tafuri; Simona Tavolaro; Twee Tsao; Maria Teresa Petrucci; Stephen L Abrams; Michael Andreeff; Paola Bergamo; Sabina Chiaretti; Ludovica Ciuffreda; Francesco Cognetti; Donatella Del Bufalo; Robin Foà; Marina Konopleva; Antonio Marchetti; Maria Grazia Mascolo; James A McCubrey; Michele Milella
Therapeutic potential of MEK inhibition in acute myelogenous leukemia: rationale for "vertical" and "lateral" combination strategies.
Journal of molecular medicine (Berlin, Germany) 2012;90(10):1133-44.
2012: James A McCubrey; Sanja Mijatovic; Michele Milella; Giuseppe Montalto; Ferdinando Nicoletti; Linda Steelman; Agostino Tafuri; Maria Clorinda Mazzarino; Steven L Abrams; Jörg Bäsecke; Saverio Candido; Melchiorre Cervello; William H Chappell; Francesca Chiarini; Lucio Cocco; Camilla Evangelisti; Paolo Fagone; Massimo Libra; Danijela Maksimovic-Ivanic; Grazia Malaponte; Alberto M Martelli
Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response.
Oncotarget 2012;3(9):954-87.
2012: Nadia Lampiasi; James A McCubrey; Giuseppe Montalto; Kazuo Umezawa; Antonina Azzolina; Melchiorre Cervello
The novel NF-κB inhibitor DHMEQ synergizes with celecoxib to exert antitumor effects on human liver cancer cells by a ROS-dependent mechanism.
Cancer letters 2012;322(1):35-44.
2012: Valentina Bevelacqua; Ylenia Bevelacqua; Saverio Candido; Fabio D'Amico; Pietro Gangemi; Claudio Guarneri; Massimo Libra; Maria Clorinda Mazzarino; James A McCubrey; Evangelia Skarmoutsou; Angela Strazzanti; Alfredo Amoroso; Grazia Malaponte
Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma.
Oncotarget 2012;3(8):882-92.
2012: Daniela Bressanin; Francesca Buontempo; Francesca Chiarini; Camilla Evangelisti; James A McCubrey; Fraia Melchionda; Pasqualepaolo Pagliaro; Andrea Pession; Francesca Ricci; Giovanna Tabellini; Pier Luigi Tazzari; Alberto M Martelli
Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: eliminating activity by targeting at different levels.
Oncotarget 2012;3(8):811-23.
2012: Melchiorre Cervello; Antonella Cusimano; Nadia Lampiasi; James A McCubrey; Antonina Azzolina; Dimcho Bachvarov; Giuseppe Montalto
Molecular mechanisms of sorafenib action in liver cancer cells.
Cell cycle (Georgetown, Tex.) 2012;11(15):2843-55.
2012: Francesca Buontempo; Francesca Chiarini; Milena Fini; James A McCubrey; Fraia Melchionda; Luca M Neri; Andrea Pession; Giovanna Tabellini; Daniela Bressanin; Alberto M Martelli
Activity of the selective IκB kinase inhibitor BMS-345541 against T-cell acute lymphoblastic leukemia: involvement of FOXO3a.
Cell cycle (Georgetown, Tex.) 2012;11(13):2467-75.
2012: Alberto M Martelli; Andrea Ognibene; Anna Maria Billi; Daniela Bressanin; Alessandra Cappellini; Francesca Chiarini; Camilla Evangelisti; Lucia Manzoli; James A McCubrey
Targeting the liver kinase B1/AMP-activated protein kinase pathway as a therapeutic strategy for hematological malignancies.
Expert opinion on therapeutic targets 2012;16(7):729-42.
2012: Ludovica Ciuffreda; Francesco Cognetti; Ruggero De Maria; Donatella Del Bufalo; Marianna Desideri; Cristina Di Sanza; Adriana Eramo; Italia Falcone; James A McCubrey; Andrea Anichini; Paola Bergamo; Francesca Biagioni; Giovanni Blandino; Ursula Cesta Incani; Augusto Orlandi; Daniela Passeri; Maria Rosaria Ricciardi; Kanaga Sabapathy; Giovanni Sette; Agostino Tafuri; Michele Milella
The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms.
Journal of molecular medicine (Berlin, Germany) 2012;90(6):667-79.
2012: Alberto M Martelli; Daniela Bressanin; Francesca Buontempo; Alessandra Cappellini; Francesca Chiarini; Camilla Evangelisti; Milena Fini; James A McCubrey
Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment.
Oncotarget 2012;3(4):371-94.
2012: Marina Konopleva; B Korchin; Duncan H Mak; James A McCubrey; Teresa McQueen; Michele Milella; Maria R Ricciardi; Peter P Ruvolo; A Tafuri; Twee Tsao; J C Watts; P Bergamo; William G Bornmann; W Chen; Michael Andreeff
MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex.
Leukemia 2012;26(4):778-87.
2012: Marija Mojic; Stanislava Stosic-Grujicic; Salvatore Tumino; Mai-Britt Zocca; Yousef Al-Abed; Svetlana Dinic; Paolo Fagone; Nevena Grdovic; Danijela Maksimovic-Ivanic; Katia Mangano; James A McCubrey; Sanja Mijatovic; Djordje Miljkovic; Ferdinando Nicoletti
Saquinavir-NO-targeted S6 protein mediates sensitivity of androgen-dependent prostate cancer cells to TRAIL.
Cell cycle (Georgetown, Tex.) 2012;11(6):1174-82.
2012: Melchiorre Cervello; Antonella Cusimano; Nadia Lampiasi; James A McCubrey; Antonina Azzolina; Giuseppe Montalto
Targeted therapy for hepatocellular carcinoma: novel agents on the horizon.
Oncotarget 2012;3(3):236-60.
2012: James A McCubrey; Sanja Mijatovic; Negin Misaghian; Giuseppeo Montalto; Ferdinando Nicoletti; Linda Steelman; Francac Stivala; Steven L Abrams; Jorg Basecke; Antonio Bonati; Melchiorre Cervello; William H Chappell; Lucio Cocco; Camilla Evangelisti; Piotr Laidler; Massimo Libra; Giovanni Ligresti; Danijela Maksimovic-Ivanic; Alberto M Martelli
Targeting the cancer initiating cell: the ultimate target for cancer therapy.
Current pharmaceutical design 2012;18(13):1784-95.
2012: Matilde Y Follo; Alberto M Martelli; James A McCubrey; Sara Mongiorgi; Manuela Piazzi; Giulia Ramazzotti; Patrizia Santi; Irene Faenza; Carlo Finelli; Lucio Cocco
Nuclear PI-PLCβ1 and myelodysplastic syndromes: genetics and epigenetics.
Current pharmaceutical design 2012;18(13):1751-4.
2012: Francesca Maira; Grazia Malaponte; James A McCubrey; Alessia Erika Russo; Saverio Candido; Alessia Catania; Massimo Libra; Concettina Fenga
Molecular targeted therapy in melanoma: a way to reverse resistance to conventional drugs.
Current drug delivery 2012;9(1):17-29.
2012: Alberto M Martelli; James A McCubrey; Francesca Ricci; Giovanna Tabellini; Roberta Bortul; Francesca Chiarini; Camilla Evangelisti; Francesco Antonio Manzoli
PI3K/AKT/mTORC1 and MEK/ERK signaling in T-cell acute lymphoblastic leukemia: new options for targeted therapy.
Advances in biological regulation 2012;52(1):214-27.
2012: Matilde Y Follo; Francesco Antonio Manzoli; Alberto M Martelli; James A McCubrey; Giulia Ramazzotti; Irene Faenza; Roberta Fiume; Lucio Cocco
Revisiting nuclear phospholipase C signalling in MDS.
Advances in biological regulation 2012;52(1):2-6.
2012: James A McCubrey; Kazuo Umezawa; Steven L Abrams; William H Chappell; Lucio Cocco; Richard A Franklin; Alberto M Martelli; Linda S Steelman
Novel approaches to target cancer initiating cells-eliminating the root of the cancer.
Advances in biological regulation 2012;52(1):249-64.
2011: Zoya N Demidenko; James A McCubrey
Recent progress in targeting cancer.
Aging 2011;3(12):1154-62.
2011: James A McCubrey; Sanja Mijatovic; Giuseppe Montalto; Ferdinando Nicoletti; Linda Steelman; Franca Stivala; Steven L Abrams; Jörg Bäsecke; Melchiorre Cervello; William H Chappell; Lucio Cocco; C Ruth Kempf; Massimo Libra; Danijela Maksimovic-Ivanic; Graziella Malaponte; Alberto M Martelli
Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways.
Journal of cellular physiology 2011;226(11):2762-81.
2011: Alberto M Martelli; James A McCubrey; Andrea Ognibene; Milena Fini; Kaoru Goto; Daniela Bressanin; Francesca Buontempo; Lucio Cocco; Camilla Evangelisti
Nuclear phosphoinositides and their roles in cell biology and disease.
Critical reviews in biochemistry and molecular biology 2011;46(5):436-57.
2011: Linda Steelman; Franca Stivala; Ellis W T Wong; Patrick Navolanic; Ferdinando Nicoletti; Steven L Abrams; William H Chappell; Lucio Cocco; Lyudmyla B Drobot; Richard A Franklin; Massimo Libra; Alberto M Martelli; James A McCubrey
Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells.
Cell cycle (Georgetown, Tex.) 2011;10(17):3003-15.
2011: Emilia Caputo; Giuliano Elia; Massimo Libra; Luigi Maiorana; Francesco M Marincola; James A McCubrey; Franca M Pezzino; Sudhir Sunkara; Salvatore Travali; Valeria Vasta; Kieran Wynne; Marian Kane
Characterization of human melanoma cell lines and melanocytes by proteome analysis.
Cell cycle (Georgetown, Tex.) 2011;10(17):2924-36.
2011: Jackson R Taylor; Linda Steelman; Steven L Abrams; William H Chappell; Brian D Lehmann; James A McCubrey
Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells.
Oncotarget 2011;2(8):610-26.
2011: Melissa L Sokolosky; Kristin M Stadelman; Linda Steelman; Franca Stivala; Steven L Abrams; William H Chappell; Lyudmyla B Drobot; Richard A Franklin; Massimo Libra; Alberto M Martelli; Ferdinando Nicoletti; James A McCubrey
Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy.
Oncotarget 2011;2(7):538-50.
2011: Linda Steelman; Franca Stivala; F Nicoletti; P Ruvolo; V Ruvolo; Steven L Abrams; Jörg Bäsecke; W Chappell; Marco Donia; Camilla Evangelisti; P Fagone; Richard A Franklin; C R Kempf; Massimo Libra; Alberto M Martelli; James A McCubrey
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.
Leukemia 2011;25(7):1080-94.
2011: Alberto M Martelli; F Nicoletti; P Ruvolo; V Ruvolo; Linda Steelman; Franca Stivala; Steven L Abrams; Jörg Bäsecke; W Chappell; Marco Donia; Camilla Evangelisti; P Fagone; C R Kempf; Massimo Libra; James A McCubrey
Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway.
Leukemia 2011;25(7):1064-79.
2011: Melchiorre Cervello; Dimcho Bachvarov; Antonella Cusimano; Francesca Sardina; Antonina Azzolina; Nadia Lampiasi; Lydia Giannitrapani; James A McCubrey; Giuseppe Montalto
COX-2-dependent and COX-2-independent mode of action of celecoxib in human liver cancer cells.
Omics : a journal of integrative biology 2011;15(6):383-92.
2011: Camilla Evangelisti; Francesca Ricci; Pier Luigi Tazzari; Giovanna Tabellini; Michela Battistelli; Elisabetta Falcieri; Francesca Chiarini; Roberta Bortul; Fraia Melchionda; P Pagliaro; Andrea Pession; James A McCubrey; Alberto M Martelli
Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia.
Leukemia 2011;25(5):781-91.
2011: Linda Steelman; Alberto M Martelli; Ferdinando Nicoletti; James A McCubrey
Exploiting p53 status to enhance effectiveness of chemotherapy by lowering associated toxicity.
Oncotarget 2011;2(3):109-12.
2011: Linda Steelman; William H Chappell; Steven L Abrams; Ruth C Kempf; Jacquelyn Long; Piotr Laidler; Sanja Mijatovic; Danijela Maksimovic-Ivanic; Franca Stivala; Maria Clorinda Mazzarino; Marco Donia; Paolo Fagone; Graziella Malaponte; Ferdinando Nicoletti; Massimo Libra; Michele Milella; Agostino Tafuri; Antonio Bonati; Jörg Bäsecke; Lucio Cocco; Camilla Evangelisti; Alberto M Martelli; Giuseppe Montalto; Melchiorre Cervello; James A McCubrey
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging.
Aging 2011;3(3):192-222.
2011: William H Chappell; Linda Steelman; Jacquelyn M Long; Ruth C Kempf; Steven L Abrams; Richard A Franklin; Jörg Bäsecke; Franca Stivala; Marco Donia; Paolo Fagone; Graziella Malaponte; Maria C Mazzarino; Ferdinando Nicoletti; Massimo Libra; Danijela Maksimovic-Ivanic; Sanja Mijatovic; Giuseppe Montalto; Melchiorre Cervello; Piotr Laidler; Michele Milella; Agostino Tafuri; Antonio Bonati; Camilla Evangelisti; Lucio Cocco; Alberto M Martelli; James A McCubrey
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health.
Oncotarget 2011;2(3):135-64.
2011: Camilla Evangelisti; Francesca Ricci; Pier Luigi Tazzari; Francesca Chiarini; Michela Battistelli; Elisabetta Falcieri; Andrea Ognibene; Pasqualepaolo Pagliaro; Lucio Cocco; James A McCubrey; Alberto M Martelli
Preclinical testing of the Akt inhibitor triciribine in T-cell acute lymphoblastic leukemia.
Journal of cellular physiology 2011;226(3):822-31.
2011: Marco Donia; Danijela Maksimovic-Ivanic; Sanja Mijatovic; Marija Mojic; Djordje Miljkovic; Gordana Timotijevic; Paolo Fagone; Salvatore Caponnetto; Yousef Al-Abed; James A McCubrey; Stanislava Stosic-Grujicic; Ferdinando Nicoletti
In vitro and in vivo anticancer action of Saquinavir-NO, a novel nitric oxide-derivative of the protease inhibitor saquinavir, on hormone resistant prostate cancer cells.
Cell cycle (Georgetown, Tex.) 2011;10(3):492-9.
2011: Alberto M Martelli; James A McCubrey; Giulia Ramazzotti; Camilla Evangelisti; Milena Fini; M Y Follo; Roberto Giardino; Lamberto Manzoli; Lucio Cocco
Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in cancer stem cells.
Current medicinal chemistry 2011;18(18):2715-26.
2011: Dorota Gil; Dorota Ciołczyk-Wierzbicka; Joanna Dulińska-Litewka; Karolina Zwawa; James A McCubrey; Piotr Laidler
The mechanism of contribution of integrin linked kinase (ILK) to epithelial-mesenchymal transition (EMT).
Advances in enzyme regulation 2011;51(1):195-207.
2011: James A McCubrey; William H Chappell; Steven L Abrams; Richard A Franklin; Jacquelyn M Long; Jennifer A Sattler; C Ruth Kempf; Piotr Laidler; Linda Steelman
Targeting the cancer initiating cell: the Achilles' heel of cancer.
Advances in enzyme regulation 2011;51(1):152-62.
2010: Marco Donia; James A McCubrey; Klaus Bendtzen; Ferdinando Nicoletti
Potential use of rapamycin in HIV infection.
British journal of clinical pharmacology 2010;70(6):784-93.
2010: Marco Donia; Bruno Cacopardo; Massimo Libra; Guido Scalia; James A McCubrey; Ferdinando Nicoletti
New perspectives in HCV therapy: entry inhibitors.
Recent patents on anti-infective drug discovery 2010;5(3):181-94.
2010: Francesca Chiarini; Cecilia Grimaldi; Francesca Ricci; Pier Luigi Tazzari; Camilla Evangelisti; Andrea Ognibene; Michela Battistelli; Elisabetta Falcieri; Fraia Melchionda; Andrea Pession; Pasqualepaolo Pagliaro; James A McCubrey; Alberto M Martelli
Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against T-cell acute lymphoblastic leukemia.
Cancer research 2010;70(20):8097-107.
2010: Alberto M Martelli; Camilla Evangelisti; Francesca Chiarini; Cecilia Grimaldi; Alessandra Cappellini; Andrea Ognibene; James A McCubrey
The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis.
Biochimica et biophysica acta 2010;1803(9):991-1002.
2010: Alberto M Martelli; Camilla Evangelisti; Francesca Chiarini; James A McCubrey
The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients.
Oncotarget 2010;1(2):89-103.
2010: James A McCubrey; Linda Steelman; Steven L Abrams; William H Chappell; Suzanne Russo; Roger Ove; Michele Milella; Agostino Tafuri; Paolo Lunghi; Antonio Bonati; Franca Stivala; Ferdinando Nicoletti; Massimo Libra; Alberto M Martelli; Giuseppe Montalto; Melchiorre Cervello
Emerging MEK inhibitors.
Expert opinion on emerging drugs 2010;15(2):203-23.
2010: Steven L Abrams; Linda Steelman; John G Shelton; Ellis W T Wong; William H Chappell; Jörg Bäsecke; Franca Stivala; Marco Donia; Ferdinando Nicoletti; Massimo Libra; Alberto M Martelli; James A McCubrey
The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy.
Cell cycle (Georgetown, Tex.) 2010;9(9):1781-91.
2010: Steven L Abrams; Linda Steelman; John G Shelton; William Chappell; Jörg Bäsecke; Franca Stivala; Marco Donia; Ferdinando Nicoletti; Massimo Libra; Alberto M Martelli; James A McCubrey
Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy.
Cell cycle (Georgetown, Tex.) 2010;9(9):1839-46.
2010: Alberto M Martelli; Francesca Chiarini; Camilla Evangelisti; Cecilia Grimaldi; Andrea Ognibene; Lucia Manzoli; Anna Maria Billi; James A McCubrey
The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin signaling network and the control of normal myelopoiesis.
Histology and histopathology 2010;25(5):669-80.
2010: Linda Steelman; Steven L Abrams; John G Shelton; William H Chappell; Jörg Bäsecke; Franca Stivala; Marco Donia; Ferdinando Nicoletti; Massimo Libra; Alberto M Martelli; James A McCubrey
Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs.
Cell cycle (Georgetown, Tex.) 2010;9(8):1629-38.
2010: Antonella Cusimano; Antonina Azzolina; Juan L Iovanna; Dimcho Bachvarov; James A McCubrey; Natale D'Alessandro; Giuseppe Montalto; Melchiorre Cervello
Novel combination of celecoxib and proteasome inhibitor MG132 provides synergistic antiproliferative and proapoptotic effects in human liver tumor cells.
Cell cycle (Georgetown, Tex.) 2010;9(7):1399-410.
2010: Alberto M Martelli; Veronica Papa; Pier Luigi Tazzari; Francesca Ricci; Camilla Evangelisti; Francesca Chiarini; C Grimaldi; Alessandra Cappellini; giovanni martinelli; Emanuela Ottaviani; P Pagliaro; S Horn; J Bäsecke; L H Lindner; H Eibl; James A McCubrey
Erucylphosphohomocholine, the first intravenously applicable alkylphosphocholine, is cytotoxic to acute myelogenous leukemia cells through JNK- and PP2A-dependent mechanisms.
Leukemia 2010;24(4):687-98.
2010: Giancarlo Castellano; Elena Torrisi; Giovanni Ligresti; Ferdinando Nicoletti; Grazia Malaponte; Salvatore Traval; James A McCubrey; Silvana Canevari; Massimo Libra
Yin Yang 1 overexpression in diffuse large B-cell lymphoma is associated with B-cell transformation and tumor progression.
Cell cycle (Georgetown, Tex.) 2010;9(3):557-63.
2010: Camilla Evangelisti; Gian Carlo Gaboardi; Anna Maria Billi; Andrea Ognibene; Kaoru Goto; Pier Luigi Tazzari; James A McCubrey; Alberto M Martelli
Identification of a functional nuclear export sequence in diacylglycerol kinase-zeta.
Cell cycle (Georgetown, Tex.) 2010;9(2):384-8.
2010: James A McCubrey; Steven L Abrams; Kristin Stadelman; William H Chappell; Michelle Lahair; Richard A Ferland; Linda Steelman
Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells.
Advances in enzyme regulation 2010;50(1):285-307.
2009: James A McCubrey; Linda Steelman; Steven L Abrams; William H Chappell; Suzanne Russo; Roger Ove; Michele Milella; Agostino Tafuri; Paolo Lunghi; Antonio Bonati; Franca Stivala; Ferdinando Nicoletti; Massimo Libra; Alberto M Martelli; Giuseppe Montalto; Melchiorre Cervello
Emerging Raf inhibitors.
Expert opinion on emerging drugs 2009;14(4):633-48.
2009: Linda S Steelman; James A McCubrey
Intriguing novel abilities of Nutlin-3A: induction of cellular quiescence as opposed to cellular senescence--implications for chemotherapy.
Cell cycle (Georgetown, Tex.) 2009;8(22):3634-5.
2009: Catherine Sánchez; Patricia Mendoza; Héctor Contreras; Jorge Vergara; James A McCubrey; Christian Huidobro; Enrique Castellón
Expression of multidrug resistance proteins in prostate cancer is related with cell sensitivity to chemotherapeutic drugs.
The Prostate 2009;69(13):1448-59.
2009: Alberto M Martelli; Camilla Evangelisti; Francesca Chiarini; Cecilia Grimaldi; Lucia Manzoli; James A McCubrey
Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia.
Expert opinion on investigational drugs 2009;18(9):1333-49.
2009: Nadia Lampiasi; Antonina Azzolina; Natale D'Alessandro; Kazuo Umezawa; James A McCubrey; Giuseppe Montalto; Melchiorre Cervello
Antitumor effects of dehydroxymethylepoxyquinomicin, a novel nuclear factor-kappaB inhibitor, in human liver cancer cells are mediated through a reactive oxygen species-dependent mechanism.
Molecular pharmacology 2009;76(2):290-300.
2009: Richard A Franklin; James A McCubrey
The involvement of CaM-KII in insulin induced cell proliferation.
Cell cycle (Georgetown, Tex.) 2009;8(13):1979.
2009: Alessia E Russo; Elena Torrisi; Ylenia Bevelacqua; Rosario Perrotta; Massimo Libra; James A McCubrey; Demetrios A Spandidos; Franca Stivala; Grazia Malaponte
Melanoma: molecular pathogenesis and emerging target therapies (Review).
International journal of oncology 2009;34(6):1481-9.
2009: Danijela Maksimovic-Ivanic; Sanja Mijatovic; Djordje Miljkovic; Ljubica Harhaji-Trajkovic; Gordana Timotijevic; Marija Mojic; Darrin Dabideen; Kai Fan Cheng; James A McCubrey; Katia Mangano; Yousef Al-Abed; Massimo Libra; Gianni Garotta; Stanislava Stosic-Grujicic; Ferdinando Nicoletti
The antitumor properties of a nontoxic, nitric oxide-modified version of saquinavir are independent of Akt.
Molecular cancer therapeutics 2009;8(5):1169-78.
2009: Giancarlo Castellano; Elena Torrisi; Giovanni Ligresti; Grazia Malaponte; Loredana Militello; Alessia E Russo; James A McCubrey; Silvana Canevari; Massimo Libra
The involvement of the transcription factor Yin Yang 1 in cancer development and progression.
Cell cycle (Georgetown, Tex.) 2009;8(9):1367-72.
2009: Alessandra Cappellini; Francesca Chiarini; Andrea Ognibene; James A McCubrey; Alberto M Martelli
The cyclin-dependent kinase inhibitor roscovitine and the nucleoside analog sangivamycin induce apoptosis in caspase-3 deficient breast cancer cells independent of caspase mediated P-glycoprotein cleavage: implications for therapy of drug resistant breast cancers.
Cell cycle (Georgetown, Tex.) 2009;8(9):1421-5.
2009: Giovanni Ligresti; Loredana Militello; Linda Steelman; Andrea Cavallaro; Francesco Basile; Ferdinando Nicoletti; Franca Stivala; James A McCubrey; Massimo Libra
PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches.
Cell cycle (Georgetown, Tex.) 2009;8(9):1352-8.
2009: Francesca Chiarini; Federica Falà; Pier Luigi Tazzari; Francesca Ricci; Annalisa Astolfi; Andrea Pession; Pasqualepaolo Pagliaro; James A McCubrey; Alberto M Martelli
Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia.
Cancer research 2009;69(8):3520-8.
2009: V Badireenath Konkimalla; James A McCubrey; Thomas Efferth
The role of downstream signaling pathways of the epidermal growth factor receptor for Artesunate's activity in cancer cells.
Current cancer drug targets 2009;9(1):72-80.
2009: N Misaghian; G Ligresti; Linda Steelman; Fred E Bertrand; Jörg Bäsecke; Massimo Libra; F Nicoletti; Franca Stivala; Michele Milella; A Tafuri; Melchiorre Cervello; A M Martelli; James A McCubrey
Targeting the leukemic stem cell: the Holy Grail of leukemia therapy.
Leukemia 2009;23(1):25-42.
2008: Pier Luigi Tazzari; Giovanna Tabellini; Francesca Ricci; Veronica Papa; Roberta Bortul; Francesca Chiarini; Camilla Evangelisti; giovanni martinelli; Andrea Bontadini; Lucio Cocco; James A McCubrey; Alberto M Martelli
Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells.
Cancer research 2008;68(22):9394-403.
2008: James A McCubrey; Steven L Abrams; G Ligresti; N Misaghian; E W T Wong; Linda Steelman; Jörg Bäsecke; J Troppmair; Massimo Libra; F Nicoletti; S Molton; Martin McMahon; C Evangelisti; A M Martelli
Involvement of p53 and Raf/MEK/ERK pathways in hematopoietic drug resistance.
Leukemia 2008;22(11):2080-90.
2008: Jacquelyn M Long; Charles W Bell; W Samuel Fagg; Mary E Kushman; Kevin G Becker; James A McCubrey; Mary A Farwell
Microarray and pathway analysis reveals decreased CDC25A and increased CDC42 associated with slow growth of BCL2 overexpressing immortalized breast cell line.
Cell cycle (Georgetown, Tex.) 2008;7(19):3062-73.
2008: Brian D Lehmann; Matthew S Paine; Adam M Brooks; James A McCubrey; Randall H Renegar; Rong Wang; David M Terrian
Senescence-associated exosome release from human prostate cancer cells.
Cancer research 2008;68(19):7864-71.
2008: Linda Steelman; Kristin M Stadelman; William H Chappell; Stefan Horn; Jörg Bäsecke; Melchiorre Cervello; Ferdinando Nicoletti; Massimo Libra; Franca Stivala; Alberto M Martelli; James A McCubrey
Akt as a therapeutic target in cancer.
Expert opinion on therapeutic targets 2008;12(9):1139-65.
2008: Federica Falà; William L Blalock; Pier Luigi Tazzari; Alessandra Cappellini; Francesca Chiarini; giovanni martinelli; Agostino Tafuri; James A McCubrey; Lucio Cocco; Alberto M Martelli
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia.
Molecular pharmacology 2008;74(3):884-95.
2008: Linda Steelman; Patrick M Navolanic; M L Sokolosky; J R Taylor; B D Lehmann; William H Chappell; Steven L Abrams; E W T Wong; K M Stadelman; David M Terrian; N R Leslie; A M Martelli; Franca Stivala; Massimo Libra; Richard A Franklin; James A McCubrey
Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.
Oncogene 2008;27(29):4086-95.
2008: Giovanni Ligresti; Massimo Libra; Loredana Militello; Silvia Clementi; Marco Donia; Rosa Imbesi; Grazia Malaponte; Alessandro Cappellani; James A McCubrey; Franca Stivala
Breast cancer: Molecular basis and therapeutic strategies (Review).
Molecular medicine reports 2008;1(4):451-8.
2008: James A McCubrey; Jörg Bäsecke; Melchiorre Cervello; Alberto M Martelli; Richard A Franklin
GSK-3beta is a critical mediator of tetrandrine induced cell cycle arrest and cytotoxicity.
Cancer biology & therapy 2008;7(7):1079.
2008: John Lee; Brian D Lehmann; David M Terrian; William H Chappell; Franca Stivala; Massimo Libra; Alberto M Martelli; Linda Steelman; James A McCubrey
Targeting prostate cancer based on signal transduction and cell cycle pathways.
Cell cycle (Georgetown, Tex.) 2008;7(12):1745-62.
2008: James A McCubrey; Michele Milella; Agostino Tafuri; Alberto M Martelli; Paolo Lunghi; Antonio Bonati; Melchiorre Cervello; John Lee; Linda Steelman
Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors.
Current opinion in investigational drugs (London, England : 2000) 2008;9(6):614-30.
2008: Brian D Lehmann; James A McCubrey; Matthew S Paine; Adam M Brooks; William H Chappell; David M Terrian
Distinct roles for p107 and p130 in Rb-independent cellular senescence.
Cell cycle (Georgetown, Tex.) 2008;7(9):1262-8.
2008: Richard A Franklin; James A McCubrey
A multipronged approach to prostate cancer.
Cancer biology & therapy 2008;7(4):594-5.
2008: Linda Steelman; Steven L Abrams; J Whelan; Fred E Bertrand; D E Ludwig; J Bäsecke; Massimo Libra; Franca Stivala; Michele Milella; A Tafuri; P Lunghi; A Bonati; A M Martelli; James A McCubrey
Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.
Leukemia 2008;22(4):686-707.
2008: James A McCubrey; Linda Steelman; Steven L Abrams; Fred E Bertrand; D E Ludwig; J Bäsecke; Massimo Libra; Franca Stivala; Michele Milella; A Tafuri; P Lunghi; A Bonati; A M Martelli
Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy.
Leukemia 2008;22(4):708-22.
2008: W Zhang; Marina Konopleva; Vivian Ruvolo; Teresa McQueen; RL Evans; William G Bornmann; James A McCubrey; Jorge Cortes; Michael Andreeff
Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway.
Leukemia 2008;22(4):808-18.
2008: Linda Steelman; Patrick M Navolanic; Richard A Franklin; Antonio Bonati; Massimo Libra; Franca Stivala; Alberto M Martelli; James A McCubrey
Combining chemo-, hormonal and targeted therapies to treat breast cancer (Review).
Molecular medicine reports 2008;1(2):139-60.
2008: John Lee; Linda Steelman; William H Chappell; James A McCubrey
Akt inactivates ERK causing decreased response to chemotherapeutic drugs in advanced CaP cells.
Cell cycle (Georgetown, Tex.) 2008;7(5):631-6.
2008: James A McCubrey; Melissa L Sokolosky; Brian D Lehmann; Jackson R Taylor; Patrick M Navolanic; William H Chappell; Steven L Abrams; Kristin M Stadelman; Ellis W T Wong; Negin Misaghian; Stefan Horn; Jörg Bäsecke; Massimo Libra; Franca Stivala; Giovanni Ligresti; Agostino Tafuri; Michele Milella; Marek Zarzycki; Andrzej Dzugaj; Francesca Chiarini; Camilla Evangelisti; Alberto M Martelli; David M Terrian; Richard A Franklin; Linda Steelman
Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy.
Advances in enzyme regulation 2008;48():113-35.
2007: James A McCubrey; Linda Steelman; William H Chappell; Steven L Abrams; Ellis W T Wong; Fumin Chang; Brian D Lehmann; David M Terrian; Michele Milella; Agostino Tafuri; Franca Stivala; Massimo Libra; Jorg Basecke; Camilla Evangelisti; Alberto M Martelli; Richard A Franklin
Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance.
Biochimica et biophysica acta 2007;1773(8):1263-84.
2007: Giampaolo Tortora; Roberto Bianco; gennaro daniele; Fortunato Ciardiello; James A McCubrey; Maria R Ricciardi; Ludovica Ciuffreda; Francesco Cognetti; Agostino Tafuri; Michele Milella
Overcoming resistance to molecularly targeted anticancer therapies: Rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2007;10(3):81-100.
2007: Phelps J Lambert; Aniqa Z Shahrier; Audy G Whitman; Ossie F Dyson; Adrian Reber; James A McCubrey; Shaw M Akula
Targeting the PI3K and MAPK pathways to treat Kaposi's-sarcoma-associated herpes virus infection and pathogenesis.
Expert opinion on therapeutic targets 2007;11(5):589-99.
2007: Brian D Lehmann; James A McCubrey; Holly S Jefferson; Matthew S Paine; William H Chappell; David M Terrian
A dominant role for p53-dependent cellular senescence in radiosensitization of human prostate cancer cells.
Cell cycle (Georgetown, Tex.) 2007;6(5):595-605.
2007: Katherine A B Knostman; James A McCubrey; Carl D Morrison; Zhaoxia Zhang; Charles C Capen; Sissy M Jhiang
PI3K activation is associated with intracellular sodium/iodide symporter protein expression in breast cancer.
BMC cancer 2007;7():137.
2007: James A McCubrey; Linda Steelman; Richard A Franklin; Steven L Abrams; William H Chappell; Ellis W T Wong; Brian D Lehmann; David M Terrian; Jorg Basecke; Franca Stivala; Massimo Libra; Camilla Evangelisti; Alberto M Martelli
Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.
Advances in enzyme regulation 2007;47():64-103.
2007: Richard A Franklin; James A McCubrey
Polyphenols in breast cancer treatment.
Cancer biology & therapy 2007;6(1):62-3.
2006: Ruben Garcia; Richard A Franklin; James A McCubrey
EGF induces cell motility and multi-drug resistance gene expression in breast cancer cells.
Cell cycle (Georgetown, Tex.) 2006;5(23):2820-6.
2006: Marina Konopleva; Rooha Contractor; Twee Tsao; Ismael Samudio; Peter P Ruvolo; Shinichi Kitada; Xingming Deng; Dayong Zhai; Yue-Xi Shi; Thomas B Sneed; Monique Verhaegen; Maria S Soengas; Vivian Ruvolo; Teresa McQueen; Wendy D Schober; Julie C Watt; Tilahun Jiffar; Xiaoyang Ling; Frank C Marini; David Harris; Martin Dietrich; Zeev Estrov; James A McCubrey; W Stratford May; John C Reed; Michael Andreeff
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.
Cancer cell 2006;10(5):375-88.
2006: Richard A Franklin; Oswaldo Rodriguez-Mora; Michelle M LaHair; James A McCubrey
Activation of the calcium/calmodulin-dependent protein kinases as a consequence of oxidative stress.
Antioxidants & redox signaling 2006;8(9-10):1807-17.
2006: James A McCubrey; Michelle M LaHair; Richard A Franklin
Reactive oxygen species-induced activation of the MAP kinase signaling pathways.
Antioxidants & redox signaling 2006;8(9-10):1775-89.
2006: Michelle M LaHair; Christopher J Howe; Oswaldo Rodriguez-Mora; James A McCubrey; Richard A Franklin
Molecular pathways leading to oxidative stress-induced phosphorylation of Akt.
Antioxidants & redox signaling 2006;8(9-10):1749-56.
2006: James A McCubrey; Richard A Franklin
Reactive oxygen intermediates and signaling through kinase pathways.
Antioxidants & redox signaling 2006;8(9-10):1745-8.
2006: Ruben Garcia; Richard A Franklin; James A McCubrey
Cell death of MCF-7 human breast cancer cells induced by EGFR activation in the absence of other growth factors.
Cell cycle (Georgetown, Tex.) 2006;5(16):1840-6.
2006: Oswaldo Rodriguez-Mora; Michelle M LaHair; Mark J Evans; Charles J Kovacs; Ron R Allison; Claudio Sibata; Kawana S White; James A McCubrey; Richard A Franklin
Inhibition of the CaM-kinases augments cell death in response to oxygen radicals and oxygen radical inducing cancer therapies in MCF-7 human breast cancer cells.
Cancer biology & therapy 2006;5(8):1022-30.
2006: James A McCubrey; Michelle M LaHair; Richard A Franklin
OSU-03012 in the treatment of glioblastoma.
Molecular pharmacology 2006;70(2):437-9.
2006: Fred E Bertrand; Linda Steelman; William H Chappell; Steven L Abrams; John G Shelton; Edmund R White; D L Ludwig; James A McCubrey
Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells.
Leukemia 2006;20(7):1254-60.
2006: Massimo Libra; Grazia Malaponte; Valentina Bevelacqua; Roberta Siciliano; Paola Castrogiovanni; Alberto Fulvi; Giuseppe Micali; Giovanni Ligresti; Maria Clorinda Mazzarino; Franca Stivala; Salvatore Travali; James A McCubrey
Absence of BRAF gene mutation in non-melanoma skin tumors.
Cell cycle (Georgetown, Tex.) 2006;5(9):968-70.
2006: Grazia Malaponte; Massimo Libra; Pietro Gangemi; Valentina Bevelacqua; Katia Mangano; Fabio D'Amico; Maria Clorinda Mazzarino; Franca Stivala; James A McCubrey; Salvatore Travali
Detection of BRAF gene mutation in primary choroidal melanoma tissue.
Cancer biology & therapy 2006;5(2):225-7.
2006: Manuela Indelicato; Valentina Chiarenza; Massimo Libra; Grazia Malaponte; Valentina Bevelacqua; Maurizio Marchini; James A McCubrey; Franca Stivala; Raffaella Scorza; Maria Clorinda Mazzarino
Analysis of TIMP-1 gene polymorphisms in Italian sclerodermic patients.
Journal of clinical laboratory analysis 2006;20(5):173-6.
2006: James A McCubrey; Linda Steelman; Steven L Abrams; John Lee; Fumin Chang; Fred E Bertrand; Patrick M Navolanic; David M Terrian; Richard A Franklin; Antonio B D'Assoro; Jeffrey Salisbury; Maria Clorinda Mazzarino; Franca Stivala; Massimo Libra
Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.
Advances in enzyme regulation 2006;46():249-79.
2005: Patrick W Ford; Khalief E Hamden; Audy G Whitman; Benjaman A Bryan; Vishnu Chintalgattu; James A McCubrey; Ossie F Dyson; Shaw M Akula
Cigarette smoke concentrate inhibits Kaposi's sarcoma-associated herpesvirus infection.
Virus research 2005;114(1-2):172-6.
2005: Richard A Franklin; Massimo Libra; Franca Stivala; James A McCubrey
Two targets are better than one. Promising combination therapy to treat breast cancer.
Cancer biology & therapy 2005;4(11):1190-1.
2005: Marina Konopleva; Yuexi Shi; Linda Steelman; John G Shelton; Mark F Munsell; Frank C Marini; Teresa McQueen; Rooha Contractor; James A McCubrey; Michael Andreeff
Development of a conditional in vivo model to evaluate the efficacy of small molecule inhibitors for the treatment of Raf-transformed hematopoietic cells.
Cancer research 2005;65(21):9962-70.
2005: Patrick M Navolanic; James A McCubrey
Pharmacological breast cancer therapy (review).
International journal of oncology 2005;27(5):1341-4.
2005: Massimo Libra; Manuela Indelicato; Valli De Re; Anna Linda Zignego; Annalisa Chiocchetti; Grazia Malaponte; Umberto Dianzani; Ferdinando Nicoletti; Franca Stivala; James A McCubrey; Maria Clorinda Mazzarino
Elevated Serum Levels of Osteopontin in HCV-Associated Lymphoproliferative Disorders.
Cancer biology & therapy 2005;4(11):1192-4.
2005: Takayuki Asano; Yixin Yao; Sonyo Shin; James A McCubrey; James L Abbruzzese; Shrikanth A G Reddy
Insulin receptor substrate is a mediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells.
Cancer research 2005;65(20):9164-8.
2005: John G Shelton; Linda Steelman; Steven L Abrams; Fred E Bertrand; Richard A Franklin; Martin McMahon; James A McCubrey
The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it?
Expert opinion on therapeutic targets 2005;9(5):1009-30.
2005: Massimo Libra; Grazia Malaponte; Patrick M Navolanic; Pietro Gangemi; Valentina Bevelacqua; Lidia Proietti; Bibiana Bruni; Franca Stivala; Maria Clorinda Mazzarino; Salvatore Travali; James A McCubrey
Analysis of BRAF mutation in primary and metastatic melanoma.
Cell cycle (Georgetown, Tex.) 2005;4(10):1382-4.
2005: William H Chappell; Thomas D Green; Justin D Spengeman; James A McCubrey; Shaw M Akula; Fred E Bertrand
Increased protein expression of the PTEN tumor suppressor in the presence of constitutively active Notch-1.
Cell cycle (Georgetown, Tex.) 2005;4(10):1389-95.
2005: Oswaldo Rodriguez-Mora; Michelle M LaHair; Christopher J Howe; James A McCubrey; Richard A Franklin
Calcium/calmodulin-dependent protein kinases as potential targets in cancer therapy.
Expert opinion on therapeutic targets 2005;9(4):791-808.
2005: Oswaldo Rodriguez-Mora; Michelle M LaHair; James A McCubrey; Richard A Franklin
Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells.
Cancer research 2005;65(12):5408-16.
2005: Oswaldo Rodriguez-Mora; Christopher J Howe; Michelle M LaHair; James A McCubrey; Richard A Franklin
Inhibition of CREB transcriptional activity in human T lymphocytes by oxidative stress.
Free radical biology & medicine 2005;38(12):1653-61.
2005: John G Shelton; Linda Steelman; Steven L Abrams; Edmund R White; Shaw M Akula; Richard A Franklin; Fred E Bertrand; Martin McMahon; James A McCubrey
Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines.
Cell cycle (Georgetown, Tex.) 2005;4(6):822-30.
2005: John G Shelton; Linda Steelman; Steven L Abrams; Edmund R White; Shaw M Akula; Fred E Bertrand; Richard A Franklin; James A McCubrey
Effects of endogenous epidermal growth factor receptor signaling on DNA synthesis and ERK activation in a cytokine-dependent hematopoietic cell line.
Cell cycle (Georgetown, Tex.) 2005;4(6):818-21.
2005: John Lee; Linda Steelman; James A McCubrey
Modulation of Raf/MEK/ERK kinase activity does not affect the chemoresistance profile of advanced prostate cancer cells.
International journal of oncology 2005;26(6):1637-44.
2005: Shaw M Akula; Patrick W Ford; Audy G Whitman; Khalief E Hamden; Benjaman A Bryan; Paul Cook; James A McCubrey
B-Raf-dependent expression of vascular endothelial growth factor-A in Kaposi sarcoma-associated herpesvirus-infected human B cells.
Blood 2005;105(11):4516-22.
2005: Zoya N Demidenko; Dorota H Halicka; Jan Kunicki; James A McCubrey; Zbigniew Darzynkiewicz; Mikhail V Blagosklonny
Selective killing of adriamycin-resistant (G2 checkpoint-deficient and MRP1-expressing) cancer cells by docetaxel.
Cancer research 2005;65(10):4401-7.
2005: James A McCubrey; Fred E Bertrand
Upping the bid on engineered inducible cell death.
Cancer biology & therapy 2005;4(5):537.
2005: Zoya N Demidenko; Won G An; John T Lee; Larisa Y Romanova; James A McCubrey; Mikhail V Blagosklonny
Kinase-addiction and bi-phasic sensitivity-resistance of Bcr-Abl- and Raf-1-expressing cells to imatinib and geldanamycin.
Cancer biology & therapy 2005;4(4):484-90.
2005: Rooha Contractor; Ismael Samudio; Zeev Estrov; David Harris; James A McCubrey; Stephen H Safe; Michael Andreeff; Marina Konopleva
A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia.
Cancer research 2005;65(7):2890-8.
2005: Justin D Spengeman; Thomas D Green; James A McCubrey; Fred E Bertrand
Activated EGFR promotes the survival of B-lineage acute leukemia in the absence of stromal cells.
Cell cycle (Georgetown, Tex.) 2005;4(3):483-7.
2005: M Worth Calfee; John G Shelton; James A McCubrey; Everett C Pesci
Solubility and bioactivity of the Pseudomonas quinolone signal are increased by a Pseudomonas aeruginosa-produced surfactant.
Infection and immunity 2005;73(2):878-82.
2005: Fred E Bertrand; James A McCubrey
Acquired immunodeficiency syndrome associated lymphoma.
Frontiers in bioscience : a journal and virtual library 2005;10():2972-7.
2005: Benjaman A Bryan; Ossie F Dyson; James A McCubrey; Shaw M Akula
Biology of Kaposi's sarcoma-associated herpesvirus.
Frontiers in bioscience : a journal and virtual library 2005;10():2882-91.
2005: Fred E Bertrand; J D Spengemen; John G Shelton; James A McCubrey
Inhibition of PI3K, mTOR and MEK signaling pathways promotes rapid apoptosis in B-lineage ALL in the presence of stromal cell support.
Leukemia 2005;19(1):98-102.
2005: Khalief E Hamden; Audy G Whitman; Patrick W Ford; John G Shelton; James A McCubrey; Shaw M Akula
Raf and VEGF: emerging therapeutic targets in Kaposi's sarcoma-associated herpesvirus infection and angiogenesis in hematopoietic and nonhematopoietic tumors.
Leukemia 2005;19(1):18-26.
2004: Linda Steelman; Fred E Bertrand; James A McCubrey
The complexity of PTEN: mutation, marker and potential target for therapeutic intervention.
Expert opinion on therapeutic targets 2004;8(6):537-50.
2004: Khalief E Hamden; Patrick W Ford; Audy G Whitman; Ossie F Dyson; Shi-Yuan Cheng; James A McCubrey; Shaw M Akula
Raf-induced vascular endothelial growth factor augments Kaposi's sarcoma-associated herpesvirus infection.
Journal of virology 2004;78(23):13381-90.
2004: John Lee; Linda Steelman; James A McCubrey
Phosphatidylinositol 3'-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells.
Cancer research 2004;64(22):8397-404.
2004: Daqing Wu; Chittam U Thakore; Ginger G Wescott; James A McCubrey; David M Terrian
Integrin signaling links protein kinase Cepsilon to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells.
Oncogene 2004;23(53):8659-72.
2004: Christopher J Howe; Michelle M LaHair; James A McCubrey; Richard A Franklin
Redox regulation of the calcium/calmodulin-dependent protein kinases.
The Journal of biological chemistry 2004;279(43):44573-81.
2004: James A McCubrey; John G Shelton; Linda Steelman; Richard A Franklin; Thazepadath Sreevalsan; Martin McMahon
Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells.
Oncogene 2004;23(47):7810-20.
2004: Katherine A B Knostman; Je-Yoel Cho; Kwon-Yul Ryu; Xiaoqin Lin; James A McCubrey; Timothy Hla; Catherine H Liu; Emma Di Carlo; Ruth Keri; Ming Zhang; Dae Y Hwang; William C Kisseberth; Charles C Capen; Sissy M Jhiang
Signaling through 3',5'-cyclic adenosine monophosphate and phosphoinositide-3 kinase induces sodium/iodide symporter expression in breast cancer.
The Journal of clinical endocrinology and metabolism 2004;89(10):5196-203.
2004: Patrick W Ford; Khalief E Hamden; Audy G Whitman; James A McCubrey; Shaw M Akula
Vascular endothelial growth factor augments human herpesvirus-8 (HHV-8/KSHV) infection.
Cancer biology & therapy 2004;3(9):876-81.
2004: Audy G Whitman; Khalief E Hamden; Patrick W Ford; James A McCubrey; Shaw M Akula
Role for Raf in the entry of viruses associated with AIDS (review).
International journal of oncology 2004;25(2):469-80.
2004: Shaw M Akula; Patrick W Ford; Audy G Whitman; Khalief E Hamden; John G Shelton; James A McCubrey
Raf promotes human herpesvirus-8 (HHV-8/KSHV) infection.
Oncogene 2004;23(30):5227-41.
2004: John G Shelton; William L Blalock; Edmund R White; Linda Steelman; James A McCubrey
Ability of the activated PI3K/Akt oncoproteins to synergize with MEK1 and induce cell cycle progression and abrogate the cytokine-dependence of hematopoietic cells.
Cell cycle (Georgetown, Tex.) 2004;3(4):503-12.
2004: John G Shelton; Linda Steelman; Edmund R White; James A McCubrey
Synergy between PI3K/Akt and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells.
Cell cycle (Georgetown, Tex.) 2004;3(3):372-9.
2004: Patrick M Navolanic; Shaw M Akula; James A McCubrey
Neosis and its potential role in cancer development and chemoresistance.
Cancer biology & therapy 2004;3(2):219-20.
2004: Linda Steelman; Steven C Pohnert; John G Shelton; Richard A Franklin; Fred E Bertrand; James A McCubrey
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.
Leukemia 2004;18(2):189-218.
2004: John G Shelton; Fumin Chang; John Lee; Richard A Franklin; Linda Steelman; James A McCubrey
B-raf and insulin synergistically prevent apoptosis and induce cell cycle progression in hematopoietic cells.
Cell cycle (Georgetown, Tex.) 2004;3(2):189-96.
2004: Michael Andreeff; Michele Milella; Bing Z Carter; Yoko Tabe; Maria R Ricciardi; Thomas B Sneed; Peter P Ruvolo; Rooha Contractor; Twee Tsao; Wendy D Schober; Randall Evans; Teresa McQueen; Zhihong Zeng; Steven M Kornblau; James A McCubrey; Elihu Estey; Gordon B Mills; John C Reed; Marina Konopleva
Targeted therapy of AML new concepts.
Annals of hematology 2004;83 Suppl 1():S51-3.
2003: Patrick M Navolanic; John Lee; James A McCubrey
Docetaxel cytotoxicity is enhanced by inhibition of the Raf/MEK/ERK signal transduction pathway.
Cancer biology & therapy 2003;2(6):677-8.
2003: Bing Z Carter; Michele Milella; Twee Tsao; Teresa McQueen; Wendy D Schober; Wei Hu; Nicholas Dean; Linda Steelman; James A McCubrey; Michael Andreeff
Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia.
Leukemia 2003;17(11):2081-9.
2003: John G Shelton; Phillip W Moye; Linda Steelman; William L Blalock; John Lee; Richard A Franklin; Martin McMahon; James A McCubrey
Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation.
Leukemia 2003;17(9):1765-82.
2003: Christopher J Howe; Michelle M LaHair; Penni J Robinson; Oswaldo Rodriguez-Mora; James A McCubrey; Richard A Franklin
Models of anergy in the human Jurkat T cell line.
Assay and drug development technologies 2003;1(4):537-44.
2003: Oswaldo Rodriguez-Mora; Richard A Franklin; James A McCubrey
A new hope for treatment of glioblastomas.
Cancer biology & therapy 2003;2(4):354-5.
2003: Fumin Chang; Linda Steelman; John Lee; John G Shelton; Patrick M Navolanic; William L Blalock; Richard A Franklin; James A McCubrey
Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.
Leukemia 2003;17(7):1263-93.
2003: John Lee; James A McCubrey
BAY-43-9006 Bayer/Onyx.
Current opinion in investigational drugs (London, England : 2000) 2003;4(6):757-63.
2003: William L Blalock; Patrick M Navolanic; Linda Steelman; John G Shelton; Phillip W Moye; John Lee; Richard A Franklin; A Mirza; Martin McMahon; Martyn K White; James A McCubrey
Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.
Leukemia 2003;17(6):1058-67.
2003: John G Shelton; Linda Steelman; John Lee; Steven L Knapp; William L Blalock; Phillip W Moye; Richard A Franklin; Steven C Pohnert; Amer M Mirza; Martin McMahon; James A McCubrey
Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells.
Oncogene 2003;22(16):2478-92.
2003: Fumin Chang; John Lee; Patrick M Navolanic; Linda Steelman; John G Shelton; William L Blalock; Richard A Franklin; James A McCubrey
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.
Leukemia 2003;17(3):590-603.
2003: Patrick M Navolanic; Ching-Hon Pui; R A Larson; Michael Bishop; T E Pearce; Mitchell S Cairo; Stanton C Goldman; S C Jeha; Carl Shanholtz; J P Leonard; James A McCubrey
Elitek-rasburicase: an effective means to prevent and treat hyperuricemia associated with tumor lysis syndrome, a Meeting Report, Dallas, Texas, January 2002.
Leukemia 2003;17(3):499-514.
2003: Julianne M Davis; Patrick M Navolanic; Caroline R Weinstein-Oppenheimer; Linda Steelman; Wei Hu; Marina Konopleva; Mikhail V Blagosklonny; James A McCubrey
Raf-1 and Bcl-2 induce distinct and common pathways that contribute to breast cancer drug resistance.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(3):1161-70.
2003: Fumin Chang; Linda Steelman; John G Shelton; John Lee; Patrick M Navolanic; William L Blalock; Richard Franklin; James A McCubrey
Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).
International journal of oncology 2003;22(3):469-80.
2003: Patrick M Navolanic; Linda Steelman; James A McCubrey
EGFR family signaling and its association with breast cancer development and resistance to chemotherapy (Review).
International journal of oncology 2003;22(2):237-52.
2003: Linda Steelman; William L Blalock; Xiao-Yang Wang; Phillip W Moye; John Lee; John G Shelton; Patrick M Navolanic; Julianne M Davis; Steven L Knapp; Richard A Franklin; Martyn K White; James A McCubrey
Elucidation of signal transduction pathways by retroviral infection of cells with modified oncogenes.
Methods in molecular biology (Clifton, N.J.) 2003;218():221-52.
2003: Linda Steelman; William L Blalock; Xiao-Yang Wang; Phillip W Moye; John Lee; John G Shelton; Patrick M Navolanic; Julianne M Davis; Steven L Knapp; Richard A Franklin; Martyn K White; James A McCubrey
Elucidation of signal transduction pathways by transfection of cells with modified oncogenes.
Methods in molecular biology (Clifton, N.J.) 2003;218():203-20.
2003: Linda Steelman; William L Blalock; Xiao-Yang Wang; Phillip W Moye; John Lee; John G Shelton; Patrick M Navolanic; Julianne M Davis; Steven L Knapp; Richard A Franklin; Martyn K White; James A McCubrey
Fibroblastic, hematopoietic, and hormone responsive epithelial cell lines and culture conditions for elucidation of signal transduction and drug resistance pathways by gene transfer.
Methods in molecular biology (Clifton, N.J.) 2003;218():185-201.
2002: John Lee; James A McCubrey
Targeting the Raf kinase cascade in cancer therapy--novel molecular targets and therapeutic strategies.
Expert opinion on therapeutic targets 2002;6(6):659-78.
2002: Oussama A Saleh; William L Blalock; Carlo Burrows; Linda Steelman; Parul D Doshi; John P McKearn; James A McCubrey
Enhanced ability of the progenipoietin-1 to suppress apoptosis in human hematopoietic cells.
International journal of molecular medicine 2002;10(4):385-94.
2002: Christopher J Howe; Michelle M LaHair; Jill A Maxwell; John Lee; Penni J Robinson; Oswaldo Rodriguez-Mora; James A McCubrey; Richard A Franklin
Participation of the calcium/calmodulin-dependent kinases in hydrogen peroxide-induced Ikappa B phosphorylation in human T lymphocytes.
The Journal of biological chemistry 2002;277(34):30469-76.
2002: Caroline R Weinstein-Oppenheimer; Carlo Burrows; Linda Steelman; James A McCubrey
The effects of beta-estradiol on Raf activity, cell cycle progression and growth factor synthesis in the MCF-7 breast cancer cell line.
Cancer biology & therapy 2002;1(3):256-62.
2002: Fumin Chang; Linda Steelman; James A McCubrey
Raf-induced cell cycle progression in human TF-1 hematopoietic cells.
Cell cycle (Georgetown, Tex.) 2002;1(3):220-6.
2002: John Lee; James A McCubrey
The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia.
Leukemia 2002;16(4):486-507.
2001: Caroline R Weinstein-Oppenheimer; C F Henríquez-Roldán; Julianne M Davis; Patrick M Navolanic; Oussama A Saleh; Linda Steelman; Richard A Franklin; P J Robinson; Martin McMahon; James A McCubrey
Role of the Raf signal transduction cascade in the in vitro resistance to the anticancer drug doxorubicin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(9):2898-907.
2001: James A McCubrey; William L Blalock; Oussama A Saleh; M Pearce; Carlo Burrows; Linda Steelman; John Lee; Richard A Franklin; Stephanie M Oberhaus; Phillip W Moye; Parul D Doshi; John P McKearn
Enhanced ability of daniplestim and myelopoietin-1 to suppress apoptosis in human hematopoietic cells.
Leukemia 2001;15(8):1203-16.
2001: Fumin Chang; James A McCubrey
P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells.
Oncogene 2001;20(32):4354-64.
2001: William L Blalock; M Pearce; Fumin Chang; John Lee; Steven C Pohnert; Carlo Burrows; Linda Steelman; Richard A Franklin; Martin McMahon; James A McCubrey
Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells.
Leukemia 2001;15(5):794-807.
2001: James A McCubrey; John Lee; Linda Steelman; William L Blalock; Phillip W Moye; Fumin Chang; M Pearce; John G Shelton; Martyn K White; Richard A Franklin; Steven C Pohnert
Interactions between the PI3K and Raf signaling pathways can result in the transformation of hematopoietic cells.
Cancer detection and prevention 2001;25(4):375-93.
2001: James A McCubrey; Linda Steelman; William L Blalock; John Lee; Phillip W Moye; Fumin Chang; M Pearce; John G Shelton; Martyn K White; Richard A Franklin; Steven C Pohnert
Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf.
Advances in enzyme regulation 2001;41():289-323.
2000: Caroline R Weinstein-Oppenheimer; William L Blalock; Linda Steelman; Fumin Chang; James A McCubrey
The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors.
Pharmacology & therapeutics 2000;88(3):229-79.
2000: Richard A Franklin; James A McCubrey
Kinases: positive and negative regulators of apoptosis.
Leukemia 2000;14(12):2019-34.
2000: Caroline R Weinstein-Oppenheimer; Linda Steelman; P A Algate; William L Blalock; Carlo Burrows; PE Hoyle; John Lee; Phillip W Moye; John G Shelton; Richard Franklin; James A McCubrey
Effects of deregulated Raf activation on integrin, cytokine-receptor expression and the induction of apoptosis in hematopoietic cells.
Leukemia 2000;14(11):1921-38.
2000: Richard A Franklin; PA Atherfold; James A McCubrey
Calcium-induced ERK activation in human T lymphocytes occurs via p56(Lck) and CaM-kinase.
Molecular immunology 2000;37(11):675-83.
2000: William L Blalock; Phillip W Moye; Fumin Chang; M Pearce; Linda Steelman; Martin McMahon; James A McCubrey
Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells.
Leukemia 2000;14(6):1080-96.
2000: Phillip W Moye; William L Blalock; PE Hoyle; Fumin Chang; Richard A Franklin; Caroline R Weinstein-Oppenheimer; M Pearce; Linda Steelman; Martin McMahon; James A McCubrey
Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells.
Leukemia 2000;14(6):1060-79.
2000: PE Hoyle; Phillip W Moye; Linda Steelman; William L Blalock; Richard A Franklin; M Pearce; Holly Cherwinski; E Bosch; Martin McMahon; James A McCubrey
Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism.
Leukemia 2000;14(4):642-56.
2000: William L Blalock; M Pearce; Linda Steelman; Richard A Franklin; S A McCarthy; Holly Cherwinski; Martin McMahon; James A McCubrey
A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.
Oncogene 2000;19(4):526-36.
2000: James A McCubrey; Linda Steelman; Phillip W Moye; PE Hoyle; Caroline R Weinstein-Oppenheimer; Fumin Chang; M Pearce; Martyn K White; Richard Franklin; William L Blalock
Effects of deregulated RAF and MEK1 expression on the cytokine-dependency of hematopoietic cells.
Advances in enzyme regulation 2000;40():305-37.
2000: James A McCubrey; W S May; V Duronio; A Mufson
Serine/threonine phosphorylation in cytokine signal transduction.
Leukemia 2000;14(1):9-21.
1999: William L Blalock; Caroline R Weinstein-Oppenheimer; Fumin Chang; PE Hoyle; Xiao-Yang Wang; P A Algate; Richard A Franklin; Stephanie M Oberhaus; Linda Steelman; James A McCubrey
Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs.
Leukemia 1999;13(8):1109-66.
1998: James A McCubrey; Linda Steelman; PE Hoyle; William L Blalock; Caroline R Weinstein-Oppenheimer; Richard A Franklin; Holly Cherwinski; E Bosch; Martin McMahon
Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells.
Leukemia 1998;12(12):1903-29.
1998: Xiao-Yang Wang; PE Hoyle; James A McCubrey
Characterization of proteins binding the 3' regulatory region of the IL-3 gene in IL-3-dependent and autocrine-transformed hematopoietic cells.
Leukemia 1998;12(4):520-31.
1997: Xiao-Yang Wang; James A McCubrey
Differential effects of retroviral long terminal repeats on interleukin-3 gene expression and autocrine transformation.
Leukemia 1997;11(10):1711-25.
1997: PE Hoyle; Linda Steelman; James A McCubrey
Autocrine transformation of human hematopoietic cells after transfection with an activated granulocyte/macrophage colony stimulating factor gene.
Cytokines, cellular & molecular therapy 1997;3(3):159-68.
1997: Xiao-Yang Wang; Linda Steelman; James A McCubrey
Abnormal activation of cytokine gene expression by intracisternal type A particle transposition: effects of mutations that result in autocrine growth stimulation and malignant transformation.
Cytokines, cellular & molecular therapy 1997;3(1):3-19.
1996: Xiao-Yang Wang; James A McCubrey
Malignant transformation induced by cytokine genes: a comparison of the abilities of germline and mutated interleukin 3 genes to transform hematopoietic cells by transcriptional and posttranscriptional mechanisms.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(4):487-500.
1996: Linda Steelman; P A Algate; William L Blalock; Xiao-Yang Wang; K D Prevost; PE Hoyle; James A McCubrey
Oncogenic effects of overexpression of the interleukin-3 receptor on hematopoietic cells.
Leukemia 1996;10(3):528-42.
1995: M W Mayo; Xiao-Yang Wang; P A Algate; G F Arana; PE Hoyle; Linda Steelman; James A McCubrey
Synergy between AUUUA motif disruption and enhancer insertion results in autocrine transformation of interleukin-3-dependent hematopoietic cells.
Blood 1995;86(8):3139-50.
1994: M W Mayo; Linda Steelman; James A McCubrey
Phorbol esters support the proliferation of a hematopoietic cell line by upregulating c-jun expression.
Oncogene 1994;9(7):1999-2008.
1994: P A Algate; Linda Steelman; M W Mayo; A Miyajima; James A McCubrey
Regulation of the interleukin-3 (IL-3) receptor by IL-3 in the fetal liver-derived FL5.12 cell line.
Blood 1994;83(9):2459-68.
1993: James A McCubrey; S R Smith; P A Algate; J E DeVente; Martyn K White; Linda Steelman
Retroviral infection can abrogate the factor-dependency of hematopoietic cells by autocrine and non-autocrine mechanisms depending on the presence of a functional viral oncogene.
Oncogene 1993;8(11):2905-15.
1993: P A Algate; James A McCubrey
Autocrine transformation of hemopoietic cells resulting from cytokine message stabilization after intracisternal A particle transposition.
Oncogene 1993;8(5):1221-32.
1993: T M Buttke; James A McCubrey; T C Owen
Use of an aqueous soluble tetrazolium/formazan assay to measure viability and proliferation of lymphokine-dependent cell lines.
Journal of immunological methods 1993;157(1-2):233-40.
1991: D K Ways; W Qin; R S Riddle; T D Garris; T E Bennett; Linda Steelman; James A McCubrey
Differential effect of phorbol esters and interleukin-3 on protein kinase C isoform content and kinase activity in the FDC-P1 cell line.
Blood 1991;78(10):2633-41.
1991: James A McCubrey; Linda Steelman; M W Mayo; P A Algate; R A Dellow; M Kaleko
Growth-promoting effects of insulin-like growth factor-1 (IGF-1) on hematopoietic cells: overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism.
Blood 1991;78(4):921-9.
1991: James A McCubrey; Linda Steelman; J P McKearn
Interleukin-3 and phorbol esters induce different patterns of immediate-early gene expression in an interleukin-3 dependent cell line.
Oncogene research 1991;6(1):1-12.
1990: James A McCubrey; Linda Steelman; G Sandlin; R S Riddle; D K Ways
Effects of phorbol esters on an interleukin-3-dependent cell line.
Blood 1990;76(1):63-72.
1989: James A McCubrey; Linda Steelman; R G Risser; J P McKearn
Structure and expression of the T cell receptor gamma locus in pre-B and early hemopoietic cells.
European journal of immunology 1989;19(12):2303-8.
1989: T M Buttke; S Van Cleave; Linda Steelman; James A McCubrey
Absence of unsaturated fatty acid synthesis in murine T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(16):6133-7.
1989: James A McCubrey; G Holland; J McKearn; R Risser
Abrogation of factor-dependence in two IL-3-dependent cell lines can occur by two distinct mechanisms.
Oncogene research 1989;4(2):97-109.
1986: P L Green; G D Holland; D Kaehler; J McKearn; James A McCubrey; R Risser
Determinants of Abelson murine leukemia virus pathogenesis.
Current topics in microbiology and immunology 1986;132():62-74.
1985: J P McKearn; James A McCubrey; B Fagg
Enrichment of hematopoietic precursor cells and cloning of multipotential B-lymphocyte precursors.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(21):7414-8.
1985: James A McCubrey; J P McKearn; Georges J F Köhler
Transformation of B and non-B cell lines with the 2,4,6,-trinitrophenyl (TNP)-specific immunoglobulin genes.
European journal of immunology 1985;15(11):1117-24.
1983: James A McCubrey; R Risser
Activation of nonexpressed endogenous ecotropic murine leukemia virus by transfection of genomic DNA into embryo cells.
Journal of virology 1983;45(3):950-5.
1983: R Risser; J M Horowitz; James A McCubrey
Endogenous mouse leukemia viruses.
Annual review of genetics 1983;17():85-121.
1982: James A McCubrey; J M Horowitz; R Risser
Structure and expression of endogenous ecotropic murine leukemia viruses in RF/J mice.
The Journal of experimental medicine 1982;156(5):1461-74.
1982: James A McCubrey; R Risser
Genetic interactions in the spontaneous production of endogenous murine leukemia virus in low leukemic mouse strains.
The Journal of experimental medicine 1982;156(2):337-49.
1982: James A McCubrey; R Risser
Genetic interactions in induction of endogenous murine leukemia virus from low leukemic mice.
Cell 1982;28(4):881-8.
1982: James A McCubrey; R Risser
Allelism and linkage studies of murine leukemia virus activation genes in low leukemic strains of mice.
The Journal of experimental medicine 1982;155(4):1233-8.