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Michael McDermott

Research Profile

Disorders

Chemicals & Drugs

Physiology

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Anatomy

Leukocytes, Mononuclear

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Publications

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Laura J Dickie; Paul Emery; Janina Geiler; Philip N Hawkins; Helen J Lachmann; Thirusha Lane; Orso M Lucherini; Dennis McGonagle; Philip A Robinson; Sinisa Savic; Chi H Wong; Azad M Aziz; Luca Cantarini; Robert Coughlan; Michael F McDermott
Involvement of X-box binding protein 1 and reactive oxygen species pathways in the pathogenesis of tumour necrosis factor receptor-associated periodic syndrome.
Sarah M Churchman; Paul Emery; Janina Geiler; Elizabeth A Horner; Michael F McDermott; Rekha Parmar; Maya H Buch; Leigh D Church; Frederique Ponchel
Multiplexing immunoassays for cytokine detection in the serum of patients with rheumatoid arthritis: lack of sensitivity and interference by rheumatoid factor.
Justin Gillespie; Ronald Grigg; Aiden Hempshall; Martyn Inman; Sinisa Savic; Chi Wong; Paul Emery; Michael F McDermott
Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients.

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All Publications

2012: Laura J Dickie; Paul Emery; Janina Geiler; Philip N Hawkins; Helen J Lachmann; Thirusha Lane; Orso M Lucherini; Dennis McGonagle; Philip A Robinson; Sinisa Savic; Chi H Wong; Azad M Aziz; Luca Cantarini; Robert Coughlan; Michael F McDermott
Involvement of X-box binding protein 1 and reactive oxygen species pathways in the pathogenesis of tumour necrosis factor receptor-associated periodic syndrome.
Annals of the rheumatic diseases 2012;71(12):2035-43.
2012: Sarah M Churchman; Paul Emery; Janina Geiler; Elizabeth A Horner; Michael F McDermott; Rekha Parmar; Maya H Buch; Leigh D Church; Frederique Ponchel
Multiplexing immunoassays for cytokine detection in the serum of patients with rheumatoid arthritis: lack of sensitivity and interference by rheumatoid factor.
Clinical and experimental rheumatology 2012;30(4):534-42.
2012: Justin Gillespie; Ronald Grigg; Aiden Hempshall; Martyn Inman; Sinisa Savic; Chi Wong; Paul Emery; Michael F McDermott
Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients.
Arthritis and rheumatism 2012;64(2):418-22.
2012: Sinisa Savic; Michele Battellino; Laura J Dickie; Michael F McDermott
Familial Mediterranean fever and related periodic fever syndromes/autoinflammatory diseases.
Current opinion in rheumatology 2012;24(1):103-12.
2011: Sarah R Kingsbury; Philip G Conaghan; Michael F McDermott
The role of the NLRP3 inflammasome in gout.
Journal of inflammation research 2011;4():39-49.
2011: Janina Geiler; Maya Buch; Michael F McDermott
Anti-TNF treatment in rheumatoid arthritis.
Current pharmaceutical design 2011;17(29):3141-54.
2011: belinda nedjai; Graham A Hitman; Leigh D Church; Kirsten Minden; Margo L Whiteford; Shane McKee; Susanna Stjernberg; Tom Pettersson; Annamari Ranki; Philip N Hawkins; Peter Arkwright; Michael F McDermott; Mark D Turner
Differential cytokine secretion results from p65 and c-Rel NF-κB subunit signaling in peripheral blood mononuclear cells of TNF receptor-associated periodic syndrome patients.
Cellular immunology 2011;268(2):55-9.
2011: belinda nedjai; Niamh Quillinan; Robert J Coughlan; Leigh Church; Michael F McDermott; Graham A Hitman; Mark D Turner
Lessons from anti-TNF biologics: infliximab failure in a TRAPS family with the T50M mutation in TNFRSF1A.
Advances in experimental medicine and biology 2011;691():409-19.
2011: Lydia R Coulthard; John C Taylor; Steve Eyre; James Robinson; Anthony G Wilson; John D Isaacs; Kimme Hyrich; Paul Emery; Anne Barton; Jennifer H Barrett; Ann W Morgan; Michael F McDermott
Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients.
Annals of the rheumatic diseases 2011;70(1):98-103.
2010: Janina Geiler; Michael F McDermott
Gevokizumab, an anti-IL-1β mAb for the potential treatment of type 1 and 2 diabetes, rheumatoid arthritis and cardiovascular disease.
Current opinion in molecular therapeutics 2010;12(6):755-69.
2010: Laura J Dickie; Leigh D Church; Lydia R Coulthard; Rebeccah J Mathews; Paul Emery; Michael F McDermott
Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes.
Rheumatology (Oxford, England) 2010;49(8):1466-71.
2010: Justin Gillespie; Rebeccah Mathews; Michael F McDermott
Rilonacept in the management of cryopyrin-associated periodic syndromes (CAPS).
Journal of inflammation research 2010;3():1-8.
2010: Laura J Dickie; Sinisa Savic; Azad Aziz; Michael Sprakes; Michael F McDermott
Periodic fever syndrome and autoinflammatory diseases.
F1000 medicine reports 2010;2():.
2009: Lydia R Coulthard; Danielle E White; Dominic L Jones; Michael F McDermott; Susan A Burchill
p38(MAPK): stress responses from molecular mechanisms to therapeutics.
Trends in molecular medicine 2009;15(8):369-79.
2009: Michael F McDermott
Rilonacept in the treatment of chronic inflammatory disorders.
Drugs of today (Barcelona, Spain : 1998) 2009;45(6):423-30.
2009: belinda nedjai; Graham A Hitman; Niamh Quillinan; Robert J Coughlan; Leigh Church; Michael F McDermott; Mark D Turner
Proinflammatory action of the antiinflammatory drug infliximab in tumor necrosis factor receptor-associated periodic syndrome.
Arthritis and rheumatism 2009;60(2):619-25.
2009: Leigh D Church; Michael F McDermott
Canakinumab, a fully-human mAb against IL-1beta for the potential treatment of inflammatory disorders.
Current opinion in molecular therapeutics 2009;11(1):81-9.
2008: S M Churchman; L D Church; Sinisa Savic; L R Coulthard; B Hayward; B Nedjai; Mark D Turner; R J Mathews; E Baguley; Graham A Hitman; H C Gooi; P M D Wood; P Emery; Michael F McDermott
A novel TNFRSF1A splice mutation associated with increased nuclear factor kappaB (NF-kappaB) transcription factor activation in patients with tumour necrosis factor receptor associated periodic syndrome (TRAPS).
Annals of the rheumatic diseases 2008;67(11):1589-95.
2008: Rebeccah J Mathews; Michael B Sprakes; Michael F McDermott
NOD-like receptors and inflammation.
Arthritis research & therapy 2008;10(6):228.
2008: J Barrie Ross; Laura A Finlayson; P Jennifer Klotz; Richard G B Langley; Roxanne Gaudet; Kara Thompson; Sarah M Churchman; Michael F McDermott; Philip N Hawkins
Use of anakinra (Kineret) in the treatment of familial cold autoinflammatory syndrome with a 16-month follow-up.
Journal of cutaneous medicine and surgery 2008;12(1):8-16.
2008: belinda nedjai; Graham A Hitman; Nasim Yousaf; Yuti Chernajovsky; S Stjernberg-Salmela; Tom Pettersson; Annamari Ranki; Philip N Hawkins; Peter Arkwright; Michael F McDermott; Mark D Turner
Abnormal tumor necrosis factor receptor I cell surface expression and NF-kappaB activation in tumor necrosis factor receptor-associated periodic syndrome.
Arthritis and rheumatism 2008;58(1):273-83.
2006: M Rynne; C Maclean; Alison Bybee; Michael F McDermott; Paul Emery
Hearing improvement in a patient with variant Muckle-Wells syndrome in response to interleukin 1 receptor antagonism.
Annals of the rheumatic diseases 2006;65(4):533-4.
2005: Silvia Stojanov; Michael F McDermott
The tumour necrosis factor receptor-associated periodic syndrome: current concepts.
Expert reviews in molecular medicine 2005;7(22):1-18.
2005: Nasim Yousaf; David J Gould; Ebun Omoyinmi; Linda Hammond; Rita M Mirakian; Mark D Turner; Graham A Hitman; Michael F McDermott; Yuti Chernajovsky
Tumor necrosis factor receptor I from patients with tumor necrosis factor receptor-associated periodic syndrome interacts with wild-type tumor necrosis factor receptor I and induces ligand-independent NF-kappaB activation.
Arthritis and rheumatism 2005;52(9):2906-16.
2004: Anthony Gordon; A L Lagan; Ebun Omoyinmi; L Cheung; C J Peters; Michael F McDermott; Julian L Millo; K I Welsh; P Holloway; Graham A Hitman; R D Piper; Christopher S Garrard; Charles J Hinds
TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study.
Genes and immunity 2004;5(8):631-40.
2004: Rebecca Allotey; Viswananthan Mohan; Michael F McDermott; Raj Deepa; Gopal Premalatha; Zahid Hassan; Paul G Cassell; Bernard V North; M Vaxillaire; Charles A Mein; Daniel C Swan; E O'Grady; Ambady Ramachandran; Chamukuttan Snehalatha; P J Sinnot; S K Hemmatpour; philippe froguel; Graham A Hitman
The EIF2AK3 gene region and type I diabetes in subjects from South India.
Genes and immunity 2004;5(8):648-52.
2004: Kirsten Minden; Ebun Omoyinmi; Michael F McDermott; Angela Zink
Tumour necrosis factor receptor associated periodic syndrome (TRAPS) with central nervous system involvement.
Annals of the rheumatic diseases 2004;63(10):1356-7.
2004: Michael F McDermott
A common pathway in periodic fever syndromes.
Trends in immunology 2004;25(9):457-60.
2004: Philip N Hawkins; Alison Bybee; Ebun Omoyinmi; Michael F McDermott
Response to anakinra in a de novo case of neonatal-onset multisystem inflammatory disease.
Arthritis and rheumatism 2004;50(8):2708-9.
2004: Ebun Omoyinmi; Philip N Hawkins; S Ozen; Tom Pettersson; Alison Bybee; S A McKee; Helen J Lachmann; Leena Karenko; Annamari Ranki; A Bakkaloglu; N Besbas; R Topaloglu; H M Hoffman; Graham A Hitman; Patricia Woo; Michael F McDermott
Allelic variants in genes associated with hereditary periodic fever syndromes as susceptibility factors for reactive systemic AA amyloidosis.
Genes and immunity 2004;5(4):289-93.
2004: Silvia Stojanov; Peter Lohse; Michael F McDermott; Ellen D Renner; Anja Kéry; Rita M Mirakian; LJ Hammond; Ebun Omoyinmi; Florian Hoffmann; Stephanie Zellerer; Bernd H Belohradsky
Periodic fever due to a novel TNFRSF1A mutation in a heterozygous Chinese carrier of MEFV E148Q.
Rheumatology (Oxford, England) 2004;43(4):526-7.
2004: Laetitia Agostini; Fabio Martinon; Kimberly Burns; Michael F McDermott; Philip N Hawkins; Jürg Tschopp
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
Immunity 2004;20(3):319-25.
2004: Philip N Hawkins; Helen J Lachmann; Ebun Omoyinmi; Michael F McDermott
Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra.
Arthritis and rheumatism 2004;50(2):607-12.
2003: Philip N Hawkins; Helen J Lachmann; Michael F McDermott
Interleukin-1-receptor antagonist in the Muckle-Wells syndrome.
The New England journal of medicine 2003;348(25):2583-4.
2003: Martin Grootveld; Michael F McDermott
BMS-561392. Bristol-Myers Squibb.
Current opinion in investigational drugs (London, England : 2000) 2003;4(5):598-602.
2002: Michael F McDermott; Ivona Aksentijevich
The autoinflammatory syndromes.
Current opinion in allergy and clinical immunology 2002;2(6):511-6.
2002: Michael F McDermott
Genetic clues to understanding periodic fevers, and possible therapies.
Trends in molecular medicine 2002;8(12):550-4.
2002: Peter Arkwright; Michael F McDermott; Sander M Houten; Joost Frenkel; Hans R Waterham; Ebun Omoyinmi; LJ Hammond; Rita M Mirakian; P I Tomlin; P I Vijaydurai; A J Cant
Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept.
Clinical and experimental immunology 2002;130(3):484-8.
2002: Zahid Hassan; Viswananthan Mohan; Liaquat Ali; Rebecca Allotey; Khalid Barakat; M Omar Faruque; Raj Deepa; Michael F McDermott; Alan E Jackson; Paul G Cassell; David Curtis; Susan V Gelding; Shanti Vijayaravaghan; Niklaus Gyr; david whitcomb; A K Azad Khan; Graham A Hitman
SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent.
American journal of human genetics 2002;71(4):964-8.
2002: Ebun Omoyinmi; Fabio Martinon; Philip N Hawkins; John B Ross; Daniel C Swan; David R Booth; Helen J Lachmann; Alison Bybee; Roxanne Gaudet; Patricia Woo; Conleth Feighery; Finbarr E Cotter; Margot Thome; Graham A Hitman; Jürg Tschopp; Michael F McDermott
Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis.
Arthritis and rheumatism 2002;46(9):2445-52.
2002: Babatunji-William Ogunkolade; Barbara J Boucher; Jean M Prahl; Stephen Andrew Bustin; Jacky M Burrin; Kate Noonan; Bernard V North; Nasima Mannan; Michael F McDermott; Hector F Deluca; Graham A Hitman
Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians.
Diabetes 2002;51(7):2294-300.
2002: Hanna Nevala; Leena Karenko; Susanna Stjernberg; Maria Raatikainen; Hanna Suomalainen; Anssi Lagerstedt; Jenita Rauta; Michael F McDermott; Pärt Peterson; Tom Pettersson; Annamari Ranki
A novel mutation in the third extracellular domain of the tumor necrosis factor receptor 1 in a Finnish family with autosomal-dominant recurrent fever.
Arthritis and rheumatism 2002;46(4):1061-6.
2002: Z Md Chowdhury; Michael F McDermott; S Davey; Zahid Hassan; P J Sinnott; S K Hemmatpour; S Sherwin; Liaquat Ali; Ebun Omoyinmi; Rebecca Allotey; Bernard V North; Paul G Cassell; Abul Kalam Azad Khan; Graham A Hitman
Genetic susceptibility to fibrocalculous pancreatic diabetes in Bangladeshi subjects: a family study.
Genes and immunity 2002;3(1):5-8.
2002: Ebun Omoyinmi; Avraham Zeharia; Graham A Hitman; Lina Basel-Vanagaite; Rebecca Allotey; David R Booth; Philip N Hawkins; Catherine Thacker; Denise Syndercombe-Court; Michael F McDermott
An Israeli Arab patient with a de novo TNFRSF1A mutation causing tumor necrosis factor receptor-associated periodic syndrome.
Arthritis and rheumatism 2002;46(1):245-9.
2001: Michael F McDermott; Joost Frenkel
Hereditary periodic fever syndromes.
The Netherlands journal of medicine 2001;59(3):118-25.
2001: Michael F McDermott
TNF and TNFR biology in health and disease.
Cellular and molecular biology (Noisy-le-Grand, France) 2001;47(4):619-35.
2001: Frank Waldron-Lynch; Claire Adams; C Amos; D K Zhu; Michael F McDermott; Fergus Shanahan; Michael G Molloy; Fergal O'Gara
Tumour necrosis factor 5' promoter single nucleotide polymorphisms influence susceptibility to rheumatoid arthritis (RA) in immunogenetically defined multiplex RA families.
Genes and immunity 2001;2(2):82-7.
2001: Ebun Omoyinmi; Ivona Aksentijevich; Graham A Hitman; Daniel Kastner; A I Hoepelman; F D Posma; E J Zweers; Michael F McDermott
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in a Dutch family: evidence for a TNFRSF1A mutation with reduced penetrance.
European journal of human genetics : EJHG 2001;9(1):63-6.
2000: Zahid Hassan; Viswananthan Mohan; Michael F McDermott; Liaquat Ali; William Ogunkolade; Ebun Omoyinmi; Paul G Cassell; Raj Deepa; A K Azad Khan; Graham A Hitman
Pancreatitis in fibrocalculous pancreatic diabetes mellitus is not associated with common mutations in the trypsinogen gene.
Diabetes/metabolism research and reviews 2000;16(6):454-57.
2000: Michael F McDermott; Ebun Omoyinmi; Graham A Hitman; Babatunji-William Ogunkolade; David R Booth; Philip N Hawkins
An autosomal dominant periodic fever associated with AA amyloidosis in a north Indian family maps to distal chromosome 1q.
Arthritis and rheumatism 2000;43(9):2034-40.
2000: Jérôme Galon; Ivona Aksentijevich; Michael F McDermott; John O'Shea; Daniel Kastner
TNFRSF1A mutations and autoinflammatory syndromes.
Current opinion in immunology 2000;12(4):479-86.
2000: William Ogunkolade; Ambady Ramachandran; Michael F McDermott; T R Kumarajeewa; David Curtis; Chamukuttan Snehalatha; Viswananthan Mohan; Paul G Cassell; Joyce Eskdale; Grant Gallagher; Graham A Hitman
Family association studies of markers on chromosome 2q and Type 1 diabetes in subjects from South India.
Diabetes/metabolism research and reviews 2000;16(4):276-80.
1999: Michael F McDermott
Autosomal dominant recurrent fevers. Clinical and genetic aspects.
Revue du rhumatisme (English ed.) 1999;66(10):484-91.
1998: Michael F McDermott; Babatunji-William Ogunkolade; E M McDermott; L C Jones; Y Wan; Kathleen A Quane; J McCarthy; M Phelan; Michael G Molloy; R J Powell; C I Amos; Graham A Hitman
Linkage of familial Hibernian fever to chromosome 12p13.
American journal of human genetics 1998;62(6):1446-51.
1998: Michael F McDermott; E M McDermott; Kathleen A Quane; L C Jones; Babatunji-William Ogunkolade; D Curtis; Frank Waldron-Lynch; M Phelan; Graham A Hitman; Michael G Molloy; R J Powell
Exclusion of the familial Mediterranean fever locus as a susceptibility region for autosomal dominant familial Hibernian fever.
Journal of medical genetics 1998;35(5):432-4.
1998: Graham A Hitman; Nasima Mannan; Michael F McDermott; Ebun Omoyinmi; Babatunji-William Ogunkolade; C N Hales; Barbara J Boucher
Vitamin D receptor gene polymorphisms influence insulin secretion in Bangladeshi Asians.
Diabetes 1998;47(4):688-90.
1997: Michael F McDermott; A Ramachandran; Babatunji-William Ogunkolade; Ebun Omoyinmi; D Curtis; Barbara J Boucher; Chamukuttan Snehalatha; Graham A Hitman
Allelic variation in the vitamin D receptor influences susceptibility to IDDM in Indian Asians.
Diabetologia 1997;40(8):971-5.
1996: Michael F McDermott; G Schmidt-Wolf; Animesh Sinha; M Koo; M A Porter; L Briant; Anne Cambon-Thomsen; N K Maclaren; D Fiske; S Bertera; Massimo Trucco; C I Amos; H O McDevitt; Daniel Kastner
No linkage or association of telomeric and centromeric T-cell receptor beta-chain markers with susceptibility to type 1 insulin-dependent diabetes in HLA-DR4 multiplex families.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 1996;23(5):361-70.
1996: B Mulcahy; Frank Waldron-Lynch; Michael F McDermott; C Adams; Christopher I Amos; D K Zhu; R H Ward; D O Clegg; F Shanahan; Michael G Molloy; Fergal O'Gara
Genetic variability in the tumor necrosis factor-lymphotoxin region influences susceptibility to rheumatoid arthritis.
American journal of human genetics 1996;59(3):676-83.