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Ultan McDermott

Research Profile

Physiology

Chemicals & Drugs

Anatomy

Disorders

Genes & Molecular Sequences

Genes, p53

Co-author Network

Publications

TOP 3
Alexandre Puissant; Jun Qi; William A Weiss; Rhamy Zeid; Gabriela Alexe; Christopher F Bassil; Cyril H Benes; James E Bradner; Yvan H Chanthery; Stacey M Frumm; Matthew J Garnett; Patricia Greninger; William Clay Gustafson; Andrew L Kung; Ultan McDermott; Erin A Nekritz; Kimberly Stegmaier
Targeting MYCN in neuroblastoma by BET bromodomain inhibition.
Lei He; Ultan McDermott; Saranya Ramakrishnan; Stephen M Rothenberg; Kristine Torres-Lockhart; Cyril H Benes; Nicole Forster; Mathew J Garnett; Patricia Greninger; Leif W Ellisen
Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma.
Stefan Hart; Ramesh Jayaraman; Babita Madan; Ultan McDermott; Nurulhuda Mustafa; Harish Nagaraj; Bee Kheng Ng; veronica Novotny-diermayr; Lai Chun Ong; Khalid M Pasha; Yong Cheng Tan; Meredith Williams; Chithra Amalini; Cyril Benes; Albert Cheong; Wee Joo Chng; Brian Dymock; Kantharaj Ethirajulu; Mathew Garnett; Boon Cher Goh; Kee Chuan Goh; Jeanette M Wood
VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.

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All Publications

2013: Alexandre Puissant; Jun Qi; William A Weiss; Rhamy Zeid; Gabriela Alexe; Christopher F Bassil; Cyril H Benes; James E Bradner; Yvan H Chanthery; Stacey M Frumm; Matthew J Garnett; Patricia Greninger; William Clay Gustafson; Andrew L Kung; Ultan McDermott; Erin A Nekritz; Kimberly Stegmaier
Targeting MYCN in neuroblastoma by BET bromodomain inhibition.
Cancer discovery 2013;3(3):308-23.
2013: Lei He; Ultan McDermott; Saranya Ramakrishnan; Stephen M Rothenberg; Kristine Torres-Lockhart; Cyril H Benes; Nicole Forster; Mathew J Garnett; Patricia Greninger; Leif W Ellisen
Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma.
Cancer discovery 2013;3(3):324-37.
2013: Stefan Hart; Ramesh Jayaraman; Babita Madan; Ultan McDermott; Nurulhuda Mustafa; Harish Nagaraj; Bee Kheng Ng; veronica Novotny-diermayr; Lai Chun Ong; Khalid M Pasha; Yong Cheng Tan; Meredith Williams; Chithra Amalini; Cyril Benes; Albert Cheong; Wee Joo Chng; Brian Dymock; Kantharaj Ethirajulu; Mathew Garnett; Boon Cher Goh; Kee Chuan Goh; Jeanette M Wood
VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.
Molecular cancer therapeutics 2013;12(2):151-61.
2013: Michael P Menden; Pedro J Ballester; Cyril H Benes; Mathew Garnett; Francesco Iorio; Ultan McDermott; Julio Saez-Rodriguez
Machine learning prediction of cancer cell sensitivity to drugs based on genomic and chemical properties.
PloS one 2013;8(4):e61318.
2013: Wanjuan Yang; David M Beare; Cyril Benes; Nidhi Bindal; Elena J Edelman; Simon Forbes; P Andrew Futreal; Patricia Greninger; Daniel A Haber; Howard Lightfoot; Ultan McDermott; Sridhar Ramaswamy; James A Smith; Jorge Soares; Michael R Stratton; I Richard Thompson; Mathew J Garnett
Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells.
Nucleic acids research 2013;41(Database issue):D955-61.
2012: Sidong Huang; Theo Knijnenburg; Ultan McDermott; Lorenza Mittempergher; Jacques Neefjes; Wouter Nijkamp; Anirudh Prahallad; Paul Roepman; Ramon Salazar; Andreas Schlicker; Chong Sun; Fumihiro Tanaka; Peter ten Dijke; Hidetaka Uramoto; Lodewyk F A Wessels; Mathew Garnett; Wipawadee Grernrum; Floris H Groenendijk; Michael Hölzel; Roderick L Beijersbergen; René Bernards
MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling.
Cell 2012;151(5):937-50.
2012: Mathew J Garnett; Ultan McDermott
Exploiting genetic complexity in cancer to improve therapeutic strategies.
Drug discovery today 2012;17(5-6):188-93.
2011: Ultan McDermott; James R Downing; Michael R Stratton
Genomics and the continuum of cancer care.
The New England journal of medicine 2011;364(4):340-50.
2011: Jeongeun Lee; Morgan L Maeder; Ultan McDermott; Sridhar Ramaswamy; Andrew S Hirsh; Sailajah Janarthanan; J Keith Joung; Magdalena Lang; Rajasekhar Singavarapu; Ben S Wittner; Vijay Yajnik; Dennis C Sgroi
Induction of stable drug resistance in human breast cancer cells using a combinatorial zinc finger transcription factor library.
PloS one 2011;6(7):e21112.
2010: Donal P McLornan; Helen L Barrett; Robert Cummins; Ultan McDermott; Cliona McDowell; Susie J Conlon; Victoria M Coyle; Sandra Van Schaeybroeck; Richard Wilson; Elaine W Kay; Daniel B Longley; Patrick G Johnston
Prognostic significance of TRAIL signaling molecules in stage II and III colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(13):3442-51.
2010: Dora Dias-Santagata; Sara Akhavanfard; Serena S David; Kathy Vernovsky; Georgiana Kuhlmann; Susan L Boisvert; Hannah Stubbs; Ultan McDermott; Jeffrey Settleman; Eunice L Kwak; Jeffrey W Clark; Steven J Isakoff; Lecia V Sequist; Jeffrey A Engelman; Thomas J Lynch; Daniel A Haber; David N Louis; Leif W Ellisen; Darrell R Borger; A John Iafrate
Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine.
EMBO molecular medicine 2010;2(5):146-58.
2010: Sreenath V Sharma; Diana Y Lee; Bihua Li; Margaret P Quinlan; Fumiyuki Takahashi; Shyamala Maheswaran; Ultan McDermott; Nancy Azizian; Lee Zou; Michael A Fischbach; Kwok-Kin Wong; Kathleyn Brandstetter; Ben Wittner; Sridhar Ramaswamy; Marie Classon; Jeffrey Settleman
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations.
Cell 2010;141(1):69-80.
2010: Wenjun Zhou; Wooyoung Hur; Ultan McDermott; Amit Dutt; Wa Xian; Scott B Ficarro; Jianming Zhang; Sreenath V Sharma; Joan Brugge; Matthew Meyerson; Jeffrey Settleman; Nathanael S Gray
A structure-guided approach to creating covalent FGFR inhibitors.
Chemistry & biology 2010;17(3):285-95.
2010: Ultan McDermott; Raju V Pusapati; James G Christensen; Nathanael S Gray; Jeffrey Settleman
Acquired resistance of non-small cell lung cancer cells to MET kinase inhibition is mediated by a switch to epidermal growth factor receptor dependency.
Cancer research 2010;70(4):1625-34.
2009: Ultan McDermott; Jeffrey Settleman
Personalized cancer therapy with selective kinase inhibitors: an emerging paradigm in medical oncology.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(33):5650-9.
2009: Alice T Shaw; Beow Y Yeap; Mari Mino-Kenudson; Subba R Digumarthy; Daniel B Costa; C. Rebecca Suk Heist; Benjamin Solomon; Hannah Stubbs; Sonal Admane; Ultan McDermott; Jeffrey Settleman; Susumu Kobayashi; Eugene J Mark; Scott J Rodig; Lucian R Chirieac; Eunice L Kwak; Thomas J Lynch; A John Iafrate
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(26):4247-53.
2009: Ultan McDermott; Rachel Y Ames; A John Iafrate; Shyamala Maheswaran; Hannah Stubbs; Patricia Greninger; Kaitlin McCutcheon; Randy Milano; Angela Tam; Diana Y Lee; Laury Lucien; Brian W Brannigan; Lindsey Ulkus; Xiao-Jun Ma; Mark G Erlander; Daniel A Haber; Sreenath V Sharma; Jeffrey Settleman
Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors.
Cancer research 2009;69(9):3937-46.
2009: Leena Gandhi; Kate McNamara; Danan Li; Christa L Borgman; Ultan McDermott; Kathleyn A Brandstetter; Robert F Padera; Lucian R Chirieac; Jeffrey E Settleman; Kwok-Kin Wong
Sunitinib prolongs survival in genetically engineered mouse models of multistep lung carcinogenesis.
Cancer prevention research (Philadelphia, Pa.) 2009;2(4):330-7.
2008: Clara Montagut; Sreenath V Sharma; Toshi Shioda; Ultan McDermott; Matthew Ulman; Lindsey Ulkus; Dora Dias-Santagata; Hannah Stubbs; Diana Y Lee; Anurag Singh; Lisa Drew; Daniel A Haber; Jeffrey Settleman
Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma.
Cancer research 2008;68(12):4853-61.
2008: Ultan McDermott; A John Iafrate; Nathanael S Gray; Toshi Shioda; Marie Classon; Shyamala Maheswaran; Wenjun Zhou; Hwan Geun Choi; Shannon L Smith; Lori Dowell; Lindsey Ulkus; Georgiana Kuhlmann; Patricia Greninger; James G Christensen; Daniel A Haber; Jeffrey Settleman
Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors.
Cancer research 2008;68(9):3389-95.
2008: Nadia Godin-Heymann; Lindsey Ulkus; Brian W Brannigan; Ultan McDermott; Jennifer Lamb; Shyamala Maheswaran; Jeffrey Settleman; Daniel A Haber
The T790M "gatekeeper" mutation in EGFR mediates resistance to low concentrations of an irreversible EGFR inhibitor.
Molecular cancer therapeutics 2008;7(4):874-9.
2008: Ultan McDermott; Sreenath V Sharma; Jeffrey Settleman
High-throughput lung cancer cell line screening for genotype-correlated sensitivity to an EGFR kinase inhibitor.
Methods in enzymology 2008;438():331-41.
2007: Ultan McDermott; Sreenath V Sharma; Lori Dowell; Patricia Greninger; Clara Montagut; Jennifer Lamb; Heidi Archibald; Raul Raudales; Angela Tam; Diana Lee; S Michael Rothenberg; Jeffrey G Supko; Raffaella Sordella; Lindsey Ulkus; A John Iafrate; Shyamala Maheswaran; Ching-Ni Njauw; Hensin Tsao; Lisa Drew; Jeff H Hanke; Xiao-Jun Ma; Mark G Erlander; Nathanael S Gray; Daniel A Haber; Jeffrey Settleman
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):19936-41.
2006: Daniel B Longley; Timothy R Wilson; Miranda McEwan; Wendy L Allen; Ultan McDermott; Leeona Galligan; Patrick G Johnston
c-FLIP inhibits chemotherapy-induced colorectal cancer cell death.
Oncogene 2006;25(6):838-48.
2005: Ultan McDermott; Daniel B Longley; Leeona Galligan; Wendy Allen; Timothy Wilson; Patrick G Johnston
Effect of p53 status and STAT1 on chemotherapy-induced, Fas-mediated apoptosis in colorectal cancer.
Cancer research 2005;65(19):8951-60.
2004: Daniel B Longley; Wendy L Allen; Ultan McDermott; Timothy R Wilson; Tariq Latif; John Boyer; Maria Lynch; Patrick G Johnston
The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(10):3562-71.
2003: Pamela J Maxwell; Daniel B Longley; Tariq Latif; John Boyer; Wendy Allen; Maria Lynch; Ultan McDermott; D Paul Harkin; Carmen J Allegra; Patrick G Johnston
Identification of 5-fluorouracil-inducible target genes using cDNA microarray profiling.
Cancer research 2003;63(15):4602-6.
2003: Daniel B Longley; Ultan McDermott; Patrick G Johnston
Predictive markers for colorectal cancer: current status and future prospects.
Clinical colorectal cancer 2003;2(4):223-30.
2002: Daniel B Longley; John Boyer; Wendy L Allen; Tariq Latif; Paul R Ferguson; Pamela J Maxwell; Ultan McDermott; Maria Lynch; D Paul Harkin; Patrick G Johnston
The role of thymidylate synthase induction in modulating p53-regulated gene expression in response to 5-fluorouracil and antifolates.
Cancer research 2002;62(9):2644-9.
2002: Ultan McDermott; Daniel B Longley; Patrick G Johnston
Molecular and biochemical markers in colorectal cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2002;13 Suppl 4():235-45.
2002: Daniel B Longley; Ultan McDermott; Patrick G Johnston
Clinical significance of prognostic and predictive markers in colorectal cancer.
The pharmacogenomics journal 2002;2(4):209-16.