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Edward McDonald

Research Profile

Chemicals & Drugs

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Drug Design

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Anatomy

Genes & Molecular Sequences

Molecular Structure

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Publications

TOP 3
Stuart C Wilson; Paul Workman; Butrus Atrash; Clare Barlow; Suzanne A Eccles; Peter M Fischer; Angela Hayes; Wayne Jackson; Michael Jarman; Lloyd Kelland; Amin Mirza; Javier Moreno; Bernard P Nutley; Florence I Raynaud; Peter Sheldrake; Mike Walton; Robert Westwood; Steven Whittaker; Edward McDonald
Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors.
Nathalie Bouloc; Jonathan M Large; Magda Kosmopoulou; Chongbo Sun; Amir Faisal; Mizio Matteucci; Jóhannes Reynisson; Nathan Brown; Butrus Atrash; Julian Blagg; Edward McDonald; Spiros Linardopoulos; Richard Bayliss; Vassilios Bavetsias
Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells.
Vassilios Bavetsias; Jonathan M Large; Chongbo Sun; Nathalie Bouloc; Magda Kosmopoulou; Mizio Matteucci; Nicola E Wilsher; Vanessa Martins; Jóhannes Reynisson; Butrus Atrash; Amir Faisal; Frederique Urban; Melanie Valenti; Alexis de Haven Brandon; Gary Box; Florence I Raynaud; Paul Workman; Suzanne A Eccles; Richard Bayliss; Julian Blagg; Spiros Linardopoulos; Edward McDonald
Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate.

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All Publications

2011: Stuart C Wilson; Paul Workman; Butrus Atrash; Clare Barlow; Suzanne A Eccles; Peter M Fischer; Angela Hayes; Wayne Jackson; Michael Jarman; Lloyd Kelland; Amin Mirza; Javier Moreno; Bernard P Nutley; Florence I Raynaud; Peter Sheldrake; Mike Walton; Robert Westwood; Steven Whittaker; Edward McDonald
Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors.
Bioorganic & medicinal chemistry 2011;19(22):6949-65.
2010: Nathalie Bouloc; Jonathan M Large; Magda Kosmopoulou; Chongbo Sun; Amir Faisal; Mizio Matteucci; Jóhannes Reynisson; Nathan Brown; Butrus Atrash; Julian Blagg; Edward McDonald; Spiros Linardopoulos; Richard Bayliss; Vassilios Bavetsias
Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells.
Bioorganic & medicinal chemistry letters 2010;20(20):5988-93.
2010: Vassilios Bavetsias; Jonathan M Large; Chongbo Sun; Nathalie Bouloc; Magda Kosmopoulou; Mizio Matteucci; Nicola E Wilsher; Vanessa Martins; Jóhannes Reynisson; Butrus Atrash; Amir Faisal; Frederique Urban; Melanie Valenti; Alexis de Haven Brandon; Gary Box; Florence I Raynaud; Paul Workman; Suzanne A Eccles; Richard Bayliss; Julian Blagg; Spiros Linardopoulos; Edward McDonald
Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate.
Journal of medicinal chemistry 2010;53(14):5213-28.
2009: Edward McDonald
Vitamins and cofactors: highlights of ESBOC 2009.
Nature chemical biology 2009;5(8):530-3.
2009: Florence I Raynaud; Suzanne A Eccles; Sonal Patel; Sonia Alix; Gary Box; Irina Chuckowree; Adrian Folkes; Sharon M Gowan; Alexis De Haven Brandon; Francesca Di-Stefano; Angela Hayes; Alan Henley; Letitia Lensun; Giles Pergl-Wilson; Anthony Robson; Nahid Saghir; Alexander Zhyvoloup; Edward McDonald; Peter Sheldrake; Stephen Shuttleworth; Melanie Valenti; Nan Chi Wan; Paul A Clarke; Paul Workman
Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941.
Molecular cancer therapeutics 2009;8(7):1725-38.
2009: Jóhannes Reynisson; William Court; Ciaran O'Neill; James Day; Lisa Patterson; Edward McDonald; Paul Workman; Matilda Katan; Suzanne A Eccles
The identification of novel PLC-gamma inhibitors using virtual high throughput screening.
Bioorganic & medicinal chemistry 2009;17(8):3169-76.
2009: Jane E Torr; Jonathan M Large; Edward McDonald
Design and combinatorial synthesis of a library of methylenesulfonamides and related compounds as potential kinase inhibitors.
Combinatorial chemistry & high throughput screening 2009;12(3):275-84.
2009: Stephen Gorsuch; Vassilios Bavetsias; Martin G Rowlands; G Wynne Aherne; Paul Workman; Michael Jarman; Edward McDonald
Synthesis of isothiazol-3-one derivatives as inhibitors of histone acetyltransferases (HATs).
Bioorganic & medicinal chemistry 2009;17(2):467-74.
2008: Corey D Gutierrez; Vassilios Bavetsias; Edward McDonald
ClTi(OiPr)3-promoted reductive amination on the solid phase: combinatorial synthesis of a biaryl-based sulfonamide library.
Journal of combinatorial chemistry 2008;10(2):280-4.
2007: Florence Chan; Chongbo Sun; Meg Perumal; Quang-De Nguyen; Vassilios Bavetsias; Edward McDonald; Vanessa Martins; Nicola E Wilsher; Florence I Raynaud; Melanie Valenti; Suzanne A Eccles; Robert te Poele; Paul Workman; Eric O Aboagye; Spiros Linardopoulos
Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity.
Molecular cancer therapeutics 2007;6(12 Pt 1):3147-57.
2007: Vassilios Bavetsias; Chongbo Sun; Nathalie Bouloc; Jóhannes Reynisson; Paul Workman; Spiros Linardopoulos; Edward McDonald
Hit generation and exploration: imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases.
Bioorganic & medicinal chemistry letters 2007;17(23):6567-71.
2007: Swee Y Sharp; Chrisostomos Prodromou; Kathy Boxall; Marissa V Powers; Joanna L Holmes; Gary Box; Thomas P Matthews; Kwai-Ming J Cheung; Andrew Kalusa; Karen James; Angela Hayes; Anthea Hardcastle; Brian Dymock; Paul A Brough; Xavier Barril; Julie E Cansfield; Lisa Wright; Allan Surgenor; Nicolas Foloppe; Roderick E Hubbard; Wynne Aherne; Laurence H Pearl; Keith Jones; Edward McDonald; Florence I Raynaud; Suzanne A Eccles; Martin J Drysdale; Paul Workman
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.
Molecular cancer therapeutics 2007;6(4):1198-211.
2007: Anthea Hardcastle; Peter Tomlin; Clair Norris; Juliet Richards; Matthew Cordwell; Kathy Boxall; Martin G Rowlands; Keith Jones; Ian Collins; Edward McDonald; Paul Workman; Wynne Aherne
A duplexed phenotypic screen for the simultaneous detection of inhibitors of the molecular chaperone heat shock protein 90 and modulators of cellular acetylation.
Molecular cancer therapeutics 2007;6(3):1112-22.
2007: Swee Y Sharp; Kathy Boxall; Martin G Rowlands; Chrisostomos Prodromou; S Mark Roe; Alison Maloney; Marissa Powers; Paul A Clarke; Gary Box; Sharon Sanderson; Lisa Patterson; Thomas P Matthews; Kwai-Ming J Cheung; Karen Ball; Angela Hayes; Florence I Raynaud; Richard Marais; Laurence H Pearl; Suzanne A Eccles; Wynne Aherne; Edward McDonald; Paul Workman
In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors.
Cancer research 2007;67(5):2206-16.
2006: Nicola F Smith; Angela Hayes; Karen James; Bernard P Nutley; Edward McDonald; Alan Henley; Brian Dymock; Martin J Drysdale; Florence I Raynaud; Paul Workman
Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors.
Molecular cancer therapeutics 2006;5(6):1628-37.
2006: Rob Howes; Xavier Barril; Brian Dymock; Kate Grant; C J Northfield; Alan G S Robertson; Allan Surgenor; J Wayne; Lisa Wright; Karen James; T Matthews; Kwai-Ming J Cheung; Edward McDonald; Paul Workman; Martin J Drysdale
A fluorescence polarization assay for inhibitors of Hsp90.
Analytical biochemistry 2006;350(2):202-13.
2006: Yvette M Newbatt; Samantha Burns; Robert Hayward; Steven Whittaker; Ruth Kirk; Christopher Marshall; Caroline Springer; Edward McDonald; Richard Marais; Paul Workman; Wynne Aherne
Identification of inhibitors of the kinase activity of oncogenic V600E BRAF in an enzyme cascade high-throughput screen.
Journal of biomolecular screening 2006;11(2):145-54.
2006: Ian Collins; John Caldwell; Tatiana Fonseca; Alastair Donald; Vassilios Bavetsias; Lisa-Jane K Hunter; Michelle D Garrett; Martin G Rowlands; G Wynne Aherne; Thomas G Davies; Valerio Berdini; Steven J Woodhead; Deborah Davis; Lisa C A Seavers; Paul G Wyatt; Paul Workman; Edward McDonald
Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B.
Bioorganic & medicinal chemistry 2006;14(4):1255-73.
2006: Edward McDonald; Keith Jones; Paul A Brough; Martin J Drysdale; Paul Workman
Discovery and development of pyrazole-scaffold Hsp90 inhibitors.
Current topics in medicinal chemistry 2006;6(11):1193-203.
2006: Edward McDonald; Paul Workman; Keith Jones
Inhibitors of the HSP90 molecular chaperone: attacking the master regulator in cancer.
Current topics in medicinal chemistry 2006;6(11):1091-107.
2005: Lindsay Stimson; Martin G Rowlands; Yvette M Newbatt; Nicola F Smith; Florence I Raynaud; Paul Rogers; Vassilios Bavetsias; Stephen Gorsuch; Michael Jarman; Andrew Bannister; Tony Kouzarides; Edward McDonald; Paul Workman; G Wynne Aherne
Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity.
Molecular cancer therapeutics 2005;4(10):1521-32.
2005: Kwai-Ming J Cheung; Thomas P Matthews; Karen James; Martin G Rowlands; Kathy Boxall; Swee Y Sharp; Alison Maloney; S Mark Roe; Chrisostomos Prodromou; Laurence H Pearl; G Wynne Aherne; Edward McDonald; Paul Workman
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(14):3338-43.
2005: Brian Dymock; Xavier Barril; Paul A Brough; Julie E Cansfield; Andrew James Massey; Edward McDonald; Roderick E Hubbard; Allan Surgenor; Stephen D Roughley; Paul Webb; Paul Workman; Lisa Wright; Martin J Drysdale
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.
Journal of medicinal chemistry 2005;48(13):4212-5.
2005: Noan-Minh Chau; Paul Rogers; Wynne Aherne; Veronica A Carroll; Ian Collins; Edward McDonald; Paul Workman; Margaret Ashcroft
Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors.
Cancer research 2005;65(11):4918-28.
2004: Jóhannes Reynisson; Edward McDonald
Tuning of hydrogen bond strength using substituents on phenol and aniline: a possible ligand design strategy.
Journal of computer-aided molecular design 2004;18(6):421-31.
2003: Michelle D Garrett; Mike I Walton; Edward McDonald; Ian Judson; Paul Workman
The contemporary drug development process: advances and challenges in preclinical and clinical development.
Progress in cell cycle research 2003;5():145-58.
2002: G Wynne Aherne; Edward McDonald; Paul Workman
Finding the needle in the haystack: why high-throughput screening is good for your health.
Breast cancer research : BCR 2002;4(4):148-54.