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Robert McDonald

Research Profile

Chemicals & Drugs

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Frank Stegmeier; Michael Rape; Viji M Draviam; Grzegorz Nalepa; Mathew E Sowa; Xiaolu L Ang; E Robert McDonald; Mamie Z Li; Gregory J Hannon; Peter K Sorger; Marc W Kirschner; J Wade Harper; Stephen J Elledge
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.
Wensheng Yang; Laura M Rozan; E Robert McDonald; Arunasalam Navaraj; Jue Judy Liu; Elizabeth M Matthew; Wenge Wang; David T Dicker; Wafik S El-Deiry
CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation.
Zhaoyu Jin; E Robert McDonald; David T Dicker; Wafik S El-Deiry
Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis.

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All Publications

2007: Frank Stegmeier; Michael Rape; Viji M Draviam; Grzegorz Nalepa; Mathew E Sowa; Xiaolu L Ang; E Robert McDonald; Mamie Z Li; Gregory J Hannon; Peter K Sorger; Marc W Kirschner; J Wade Harper; Stephen J Elledge
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.
Nature 2007;446(7138):876-81.
2007: Wensheng Yang; Laura M Rozan; E Robert McDonald; Arunasalam Navaraj; Jue Judy Liu; Elizabeth M Matthew; Wenge Wang; David T Dicker; Wafik S El-Deiry
CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation.
The Journal of biological chemistry 2007;282(5):3273-81.
2004: Zhaoyu Jin; E Robert McDonald; David T Dicker; Wafik S El-Deiry
Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis.
The Journal of biological chemistry 2004;279(34):35829-39.
2004: E Robert McDonald; Wafik S El-Deiry
Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6170-5.
2003: Paul G Corn; E Robert McDonald; James G Herman; Wafik S El-Deiry
Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein.
Nature genetics 2003;35(3):229-37.
2003: E Robert McDonald; Wafik S El-Deiry
Yeast two-hybrid screening as a means of deciphering tumor suppressor pathways.
Methods in molecular biology (Clifton, N.J.) 2003;223():173-85.
2001: E Robert McDonald; Patricia C Chui; P F Martelli; David T Dicker; Wafik S El-Deiry
Death domain mutagenesis of KILLER/DR5 reveals residues critical for apoptotic signaling.
The Journal of biological chemistry 2001;276(18):14939-45.
2001: E Robert McDonald; Wafik S El-Deiry
Checkpoint genes in cancer.
Annals of medicine 2001;33(2):113-22.
2000: E Robert McDonald; Wafik S El-Deiry
Cell cycle control as a basis for cancer drug development (Review).
International journal of oncology 2000;16(5):871-86.
2000: Raymond De Meng; E Robert McDonald; M S Sheikh; A J Fornace; Wafik S El-Deiry
The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(2):130-44.
1999: Gen Sheng Wu; Timothy F Burns; E Robert McDonald; Raymond De Meng; Gary D Kao; Ruth J Muschel; T Yen; Wafik S El-Deiry
Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest.
Oncogene 1999;18(47):6411-8.
1997: Gen Sheng Wu; Timothy F Burns; E Robert McDonald; W Jiang; Raymond De Meng; I D Krantz; Gary D Kao; D D Gan; J Y Zhou; Ruth J Muschel; S R Hamilton; Nancy B Spinner; S Markowitz; G Wu; Wafik S El-Deiry
KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene.
Nature genetics 1997;17(2):141-3.
1996: E Robert McDonald; Gen Sheng Wu; Todd Waldman; Wafik S El-Deiry
Repair Defect in p21 WAF1/CIP1 -/- human cancer cells.
Cancer research 1996;56(10):2250-5.