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Donald McDonnell

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
30
Norris, John
18
O'Malley, Bert
11
Chang, Ching-Yi
8
Chang, Ching-yi
8
Gaido, Kevin
6
Safe, Stephen
6
Kazmin, Dmitri
6
Nawaz, Zafar
6
Wagner, BL
5
Vegeto, Elisabetta
5
Gaillard, Stéphanie
5
Fan, Daju
5
Hall, Julie
4
Dwyer, Mary
4
Fowlkes, DM

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Publications

TOP 3
Norris John D; Chang Ching-Yi; Wittmann Bryan M; Kunder Rebecca S; Cui Huaxia; Fan Daju; Joseph James D; McDonnell Donald P
The homeodomain protein HOXB13 regulates the cellular response to androgens.
Frigo Daniel E; Sherk Andrea B; Wittmann Bryan M; Norris John D; Wang Qianben; Joseph James D; Toner Aidan P; Brown Myles; McDonnell Donald P
Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro.
Grasfeder Linda L; Gaillard Stephanie; Hammes Stephen R; Ilkayeva Olga; Newgard Christopher B; Hochberg Richard B; Dwyer Mary A; Chang Ching-Yi; McDonnell Donald P
Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha.

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All Publications

2009: Norris John D; Chang Ching-Yi; Wittmann Bryan M; Kunder Rebecca S; Cui Huaxia; Fan Daju; Joseph James D; McDonnell Donald P
The homeodomain protein HOXB13 regulates the cellular response to androgens.
Molecular cell 2009;36(3):405-16.
2009: Frigo Daniel E; Sherk Andrea B; Wittmann Bryan M; Norris John D; Wang Qianben; Joseph James D; Toner Aidan P; Brown Myles; McDonnell Donald P
Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro.
Molecular endocrinology (Baltimore, Md.) 2009;23(9):1385-96.
2009: Grasfeder Linda L; Gaillard Stephanie; Hammes Stephen R; Ilkayeva Olga; Newgard Christopher B; Hochberg Richard B; Dwyer Mary A; Chang Ching-Yi; McDonnell Donald P
Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha.
Molecular endocrinology (Baltimore, Md.) 2009;23(8):1171-82.
2009: Joseph James D; Wittmann Bryan M; Dwyer Mary A; Cui Huaxia; Dye Delita A; McDonnell Donald P; Norris John D
Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):12178-83.
2009: Norris John David; Joseph James David; Sherk Andrea Barreto; Juzumiene Dalia; Turnbull Philip Stewart; Rafferty Stephen William; Cui Huaxia; Anderson Erin; Fan Daju; Dye Delita Arnelle; Deng Xiang; Kazmin Dmitri; Chang Ching-Yi; Willson Timothy Mark; McDonnell Donald Patrick
Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands.
Chemistry & biology 2009;16(4):452-60.
2009: Stein Rebecca A; Gaillard Stéphanie; McDonnell Donald P
Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells.
The Journal of steroid biochemistry and molecular biology 2009;114(1-2):106-12.
2009: Safi Rachid; Muramoto Garrett G; Salter Alice B; Meadows Sarah; Himburg Heather; Russell Lauren; Daher Pamela; Doan Phuong; Leibowitz Mark D; Chao Nelson J; McDonnell Donald P; Chute John P
Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture.
Molecular endocrinology (Baltimore, Md.) 2009;23(2):188-201.
2008: Stein Rebecca A; Chang Ching-Yi; Kazmin Dmitri A; Way James; Schroeder Thies; Wergin Melanie; Dewhirst Mark W; McDonnell Donald P
Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer.
Cancer research 2008;68(21):8805-12.
2008: DuSell Carolyn D; McDonnell Donald P
27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling.
Trends in pharmacological sciences 2008;29(10):510-4.
2008: Sherk Andrea B; Frigo Daniel E; Schnackenberg Christine G; Bray Jeffrey D; Laping Nicholas J; Trizna Walter; Hammond Marlys; Patterson Jaclyn R; Thompson Scott K; Kazmin Dmitri; Norris John D; McDonnell Donald P
Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic.
Cancer research 2008;68(18):7475-83.
2008: Frigo Daniel E; McDonnell Donald P
Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation.
Molecular cancer therapeutics 2008;7(3):659-69.
2008: DuSell Carolyn D; Umetani Michihisa; Shaul Philip W; Mangelsdorf David J; McDonnell Donald P
27-hydroxycholesterol is an endogenous selective estrogen receptor modulator.
Molecular endocrinology (Baltimore, Md.) 2008;22(1):65-77.
2007: Wittmann Bryan M; Sherk Andrea; McDonnell Donald P
Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators.
Cancer research 2007;67(19):9549-60.
2007: Mettu Niharika B; Stanley Thomas B; Dwyer Mary A; Jansen Michelle S; Allen John E; Hall Julie M; McDonnell Donald P
The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator-activated receptors.
Molecular endocrinology (Baltimore, Md.) 2007;21(10):2361-77.
2007: Hall Julie M; McDonnell Donald P
The molecular mechanisms underlying the proinflammatory actions of thiazolidinediones in human macrophages.
Molecular endocrinology (Baltimore, Md.) 2007;21(8):1756-68.
2007: Gaillard Stéphanie; Dwyer Mary A; McDonnell Donald P
Definition of the molecular basis for estrogen receptor-related receptor-alpha-cofactor interactions.
Molecular endocrinology (Baltimore, Md.) 2007;21(1):62-76.
2006: Gaillard Stéphanie; Grasfeder Linda L; Haeffele Christiane L; Lobenhofer Edward K; Chu Tzu-Ming; Wolfinger Russ; Kazmin Dmitri; Koves Timothy R; Muoio Deborah M; Chang Ching-yi; McDonnell Donald P
Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs.
Molecular cell 2006;24(5):797-803.
2006: McDonnell Donald P
Mechanism-based discovery as an approach to identify the next generation of estrogen receptor modulators.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(14):2432-4.
2006: Chute John P; Muramoto Garrett G; Whitesides John; Colvin Michael; Safi Rachid; Chao Nelson J; McDonnell Donald P
Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11707-12.
2006: Noble Schroeder M; Carnahan Virginia E; Moore Linda B; Luntz Tom; Wang Hongbing; Ittoop Olivia R; Stimmel Julie B; Davis-Searles Paula R; Watkins Ryan E; Wisely G Bruce; LeCluyse Ed; Tripathy Ashutosh; McDonnell Donald P; Redinbo Matthew R
Human PXR forms a tryptophan zipper-mediated homodimer.
Biochemistry 2006;45(28):8579-89.
2006: Kazmin Dmitri; Prytkova Tatiana; Cook C Edgar; Wolfinger Russell; Chu Tzu-Ming; Beratan David; Norris J D; Chang Ching-yi; McDonnell Donald P
Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators.
Molecular endocrinology (Baltimore, Md.) 2006;20(6):1201-17.
2005: Hall Julie M; McDonnell Donald P
Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting.
Molecular interventions 2005;5(6):343-57.
2005: Safi Rachid; Kovacic Agnes; Gaillard Stéphanie; Murata Yoko; Simpson Evan R; McDonnell Donald P; Clyne Colin D
Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy.
Cancer research 2005;65(24):11762-70.
2005: Solomon Isaac H; Hager Janet M; Safi Rachid; McDonnell Donald P; Redinbo Matthew R; Ortlund Eric A
Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity.
Journal of molecular biology 2005;354(5):1091-102.
2005: Chang Ching-Yi; Abdo Jennifer; Hartney Tanya; McDonnell Donald P
Development of peptide antagonists for the androgen receptor using combinatorial peptide phage display.
Molecular endocrinology (Baltimore, Md.) 2005;19(10):2478-90.
2005: Wu Ya-Ling; Yang Xiaojing; Ren Zhong; McDonnell Donald P; Norris John D; Willson Timothy M; Greene Geoffrey L
Structural basis for an unexpected mode of SERM-mediated ER antagonism.
Molecular cell 2005;18(4):413-24.
2005: Chang Ching-yi; McDonnell Donald P
Androgen receptor-cofactor interactions as targets for new drug discovery.
Trends in pharmacological sciences 2005;26(5):225-8.
2005: Ortlund Eric A; Lee Yoonkwang; Solomon Isaac H; Hager Janet M; Safi Rachid; Choi Yunhee; Guan Ziqiang; Tripathy Ashutosh; Raetz Christian R H; McDonnell Donald P; Moore David D; Redinbo Matthew R
Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP.
Nature structural & molecular biology 2005;12(4):357-63.
2005: Shaffer Paul L; McDonnell Donald P; Gewirth Daniel T
Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor.
Biochemistry 2005;44(7):2678-85.
2005: McDonnell Donald P
The molecular pharmacology of estrogen receptor modulators: implications for the treatment of breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 2):871s-7s.
2005: Juzumiene Dalia; Chang Ching-yi; Fan Daju; Hartney Tanya; Norris John D; McDonnell Donald P
Single-step purification of full-length human androgen receptor.
Nuclear receptor signaling 2005;3():e001.
2004: McDonnell Donald P
The molecular determinants of estrogen receptor pharmacology.
Maturitas 2004;48 Suppl 1():S7-12.
2004: Jansen Michelle S; Nagel Susan C; Miranda Phillippa J; Lobenhofer Edward K; Afshari Cynthia A; McDonnell Donald P
Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):7199-204.
2003: Sathya Ganesan; Chang Ching-yi; Kazmin Dmitri; Cook C Edgar; McDonnell Donald P
Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion.
Cancer research 2003;63(22):8029-36.
2003: McDonnell Donald P
Mining the complexities of the estrogen signaling pathways for novel therapeutics.
Endocrinology 2003;144(10):4237-40.
2003: Rincavage Heather L; McDonnell Donald P; Kuhn Cynthia M
Expression of functional estrogen receptor beta in locus coeruleus-derived Cath.a cells.
Endocrinology 2003;144(7):2829-35.
2003: Chang Ching-yi; Norris John D; Jansen Michelle; Huang Huey-Jing; McDonnell Donald P
Application of random peptide phage display to the study of nuclear hormone receptors.
Methods in enzymology 2003;364():118-42.
2002: Huang Huey-Jing; Norris John D; McDonnell Donald P
Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists.
Molecular endocrinology (Baltimore, Md.) 2002;16(8):1778-92.
2002: Sathya Ganesan; Jansen Michelle S; Nagel Susan C; Cook C Edgar; McDonnell Donald P
Identification and characterization of novel estrogen receptor-beta-sparing antiprogestins.
Endocrinology 2002;143(8):3071-82.
2002: McDonnell Donald P; Wijayaratne Ashini; Chang Ching-yi; Norris John D
Elucidation of the molecular mechanism of action of selective estrogen receptor modulators.
The American journal of cardiology 2002;90(1A):35F-43F.
2002: Li Xiaolin; Kimbrel Erin A; Kenan Daniel J; McDonnell Donald P
Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation.
Molecular endocrinology (Baltimore, Md.) 2002;16(7):1482-91.
2002: Li Xiaolin; McDonnell Donald P
The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.
Molecular and cellular biology 2002;22(11):3663-73.
2002: McDonnell Donald P; Norris John D
Connections and regulation of the human estrogen receptor.
Science (New York, N.Y.) 2002;296(5573):1642-4.
2002: Chang Ching-Yi; McDonnell Donald P
Evaluation of ligand-dependent changes in AR structure using peptide probes.
Molecular endocrinology (Baltimore, Md.) 2002;16(4):647-60.
2002: Norris John D; Fan Daju; Sherk Andrea; McDonnell Donald P
A negative coregulator for the human ER.
Molecular endocrinology (Baltimore, Md.) 2002;16(3):459-68.
2002: McDonnell Donald P; Connor Caroline E; Wijayaratne Ashini; Chang Ching-Yi; Norris John D
Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators.
Recent progress in hormone research 2002;57():295-316.
2001: McDonnell D P; Chang C Y; Norris J D
Capitalizing on the complexities of estrogen receptor pharmacology in the quest for the perfect SERM.
Annals of the New York Academy of Sciences 2001;949():16-35.
2001: Chang C Y; Walther P J; McDonnell D P
Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer.
Cancer research 2001;61(24):8712-7.
2001: Nagel S C; Hagelbarger J L; McDonnell D P
Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics.
Endocrinology 2001;142(11):4721-8.
2001: Wijayaratne A L; McDonnell D P
The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators.
The Journal of biological chemistry 2001;276(38):35684-92.
2001: Hamilton M H; Tcherepanova I; Huibregtse J M; McDonnell D P
Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates.
The Journal of biological chemistry 2001;276(28):26324-31.
2001: Connor C E; Norris J D; Broadwater G; Willson T M; Gottardis M M; Dewhirst M W; McDonnell D P
Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor.
Cancer research 2001;61(7):2917-22.
2001: Norris J D; Chang C; McDonnell D P
Estrogen receptor-cofactor interactions as targets for novel drug discovery.
Ernst Schering Research Foundation workshop 2001;(34):181-201.
2000: Hall J M; Chang C Y; McDonnell D P
Development of peptide antagonists that target estrogen receptor beta-coactivator interactions.
Molecular endocrinology (Baltimore, Md.) 2000;14(12):2010-23.
2000: McDonnell D P; Chang C Y; Norris J D
Development of peptide antagonists that target estrogen receptor-cofactor interactions.
The Journal of steroid biochemistry and molecular biology 2000;74(5):327-35.
2000: Gaido K W; Maness S C; McDonnell D P; Dehal S S; Kupfer D; Safe S
Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies.
Molecular pharmacology 2000;58(4):852-8.
2000: Giangrande P H; Kimbrel E A; Edwards D P; McDonnell D P
The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding.
Molecular and cellular biology 2000;20(9):3102-15.
2000: Tcherepanova I; Puigserver P; Norris J D; Spiegelman B M; McDonnell D P
Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1.
The Journal of biological chemistry 2000;275(21):16302-8.
2000: McDonnell D P
Selective estrogen receptor modulators (SERMs): A first step in the development of perfect hormone replacement therapy regimen.
Journal of the Society for Gynecologic Investigation 2000;7(1 Suppl):S10-5.
1999: Wijayaratne A L; Nagel S C; Paige L A; Christensen D J; Norris J D; Fowlkes D M; McDonnell D P
Comparative analyses of mechanistic differences among antiestrogens.
Endocrinology 1999;140(12):5828-40.
1999: Gaido K W; Leonard L S; Maness S C; Hall J M; McDonnell D P; Saville B; Safe S
Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta.
Endocrinology 1999;140(12):5746-53.
1999: Hall J M; McDonnell D P
The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens.
Endocrinology 1999;140(12):5566-78.
1999: Chang C y; Norris J D; Grøn H; Paige L A; Hamilton P T; Kenan D J; Fowlkes D; McDonnell D P
Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta.
Molecular and cellular biology 1999;19(12):8226-39.
1999: Norris J D; Paige L A; Christensen D J; Chang C Y; Huacani M R; Fan D; Hamilton P T; Fowlkes D M; McDonnell D P
Peptide antagonists of the human estrogen receptor.
Science (New York, N.Y.) 1999;285(5428):744-6.
1999: Improta-Brears T; Whorton A R; Codazzi F; York J D; Meyer T; McDonnell D P
Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4686-91.
1999: Paige L A; Christensen D J; Grøn H; Norris J D; Gottlin E B; Padilla K M; Chang C Y; Ballas L M; Hamilton P T; McDonnell D P; Fowlkes D M
Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3999-4004.
1999: Wagner B L; Pollio G; Giangrande P; Webster J C; Breslin M; Mais D E; Cook C E; Vedeckis W V; Cidlowski J A; McDonnell D P
The novel progesterone receptor antagonists RTI 3021-012 and RTI 3021-022 exhibit complex glucocorticoid receptor antagonist activities: implications for the development of dissociated antiprogestins.
Endocrinology 1999;140(3):1449-58.
1999: Giangrande P H; McDonnell D P
The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene.
Recent progress in hormone research 1999;54():291-313; discussion 313-4.
1998: Gould J C; Leonard L S; Maness S C; Wagner B L; Conner K; Zacharewski T; Safe S; McDonnell D P; Gaido K W
Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol.
Molecular and cellular endocrinology 1998;142(1-2):203-14.
1998: Maness S C; McDonnell D P; Gaido K W
Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells.
Toxicology and applied pharmacology 1998;151(1):135-42.
1998: Norris J D; Fan D; Stallcup M R; McDonnell D P
Enhancement of estrogen receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation function 2 in determining estrogen receptor pharmacology.
The Journal of biological chemistry 1998;273(12):6679-88.
1998: Wagner B L; Norris J D; Knotts T A; Weigel N L; McDonnell D P
The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor.
Molecular and cellular biology 1998;18(3):1369-78.
1997: Giangrande P H; Pollio G; McDonnell D P
Mapping and characterization of the functional domains responsible for the differential activity of the A and B isoforms of the human progesterone receptor.
The Journal of biological chemistry 1997;272(52):32889-900.
1997: Ramamoorthy K; Vyhlidal C; Wang F; Chen I; Safe S; McDonnell D P; Leonard L S; Gaido K W
Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol.
Toxicology and applied pharmacology 1997;147(1):93-100.
1997: Willson T M; Norris J D; Wagner B L; Asplin I; Baer P; Brown H R; Jones S A; Henke B; Sauls H; Wolfe S; Morris D C; McDonnell D P
Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone.
Endocrinology 1997;138(9):3901-11.
1997: Norris J D; Fan D; Kerner S A; McDonnell D P
Identification of a third autonomous activation domain within the human estrogen receptor.
Molecular endocrinology (Baltimore, Md.) 1997;11(6):747-54.
1997: Ramamoorthy K; Wang F; Chen I C; Norris J D; McDonnell D P; Leonard L S; Gaido K W; Bocchinfuso W P; Korach K S; Safe S
Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism.
Endocrinology 1997;138(4):1520-7.
1997: Gaido K W; Leonard L S; Lovell S; Gould J C; Babaï D; Portier C J; McDonnell D P
Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay.
Toxicology and applied pharmacology 1997;143(1):205-12.
1997: Ramamoorthy K; Wang F; Chen I C; Safe S; Norris J D; McDonnell D P; Gaido K W; Bocchinfuso W P; Korach K S
Potency of combined estrogenic pesticides.
Science (New York, N.Y.) 1997;275(5298):405-6.
1997: McDonnell D P; Norris J D
Analysis of the molecular pharmacology of estrogen receptor agonists and antagonists provides insights into the mechanism of action of estrogen in bone.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 1997;7 Suppl 1():S29-34.
1996: Fan J D; Wagner B L; McDonnell D P
Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity.
Molecular endocrinology (Baltimore, Md.) 1996;10(12):1605-16.
1996: Wagner B L; Pollio G; Leonhardt S; Wani M C; Lee D Y; Imhof M O; Edwards D P; Cook C E; McDonnell D P
16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8739-44.
1996: Imhof M O; McDonnell D P
Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors.
Molecular and cellular biology 1996;16(6):2594-605.
1995: Norris J; Fan D; Aleman C; Marks J R; Futreal P A; Wiseman R W; Iglehart J D; Deininger P L; McDonnell D P
Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers.
The Journal of biological chemistry 1995;270(39):22777-82.
1995: McDonnell D P; Clemm D L; Hermann T; Goldman M E; Pike J W
Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.
Molecular endocrinology (Baltimore, Md.) 1995;9(6):659-69.
1995: Clemm D L; Macy B L; Santiso-Mere D; McDonnell D P
Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor.
The Journal of steroid biochemistry and molecular biology 1995;53(1-6):487-95.
1995: McDonnell D P; Dana S L; Hoener P A; Lieberman B A; Imhof M O; Stein R B
Cellular mechanisms which distinguish between hormone- and antihormone-activated estrogen receptor.
Annals of the New York Academy of Sciences 1995;761():121-37.
1994: Wen D X; Xu Y F; Mais D E; Goldman M E; McDonnell D P
The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells.
Molecular and cellular biology 1994;14(12):8356-64.
1994: McDonnell D P; Clemm D L; Imhof M O
Definition of the cellular mechanisms which distinguish between hormone and antihormone activated steroid receptors.
Seminars in cancer biology 1994;5(5):327-36.
1994: Dana S L; Hoener P A; Wheeler D A; Lawrence C B; McDonnell D P
Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells.
Molecular endocrinology (Baltimore, Md.) 1994;8(9):1193-207.
1994: McDonnell D P; Shahbaz M M; Vegeto E; Goldman M E
The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity.
The Journal of steroid biochemistry and molecular biology 1994;48(5-6):425-32.
1994: McDonnell D P; Goldman M E
RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism.
The Journal of biological chemistry 1994;269(16):11945-9.
1994: Tzukerman M T; Esty A; Santiso-Mere D; Danielian P; Parker M G; Stein R B; Pike J W; McDonnell D P
Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.
Molecular endocrinology (Baltimore, Md.) 1994;8(1):21-30.
1993: McDonnell D P; Clevenger B; Dana S; Santiso-Mere D; Tzukerman M T; Gleeson M A
The mechanism of action of steroid hormones: a new twist to an old tale.
Journal of clinical pharmacology 1993;33(12):1165-72.
1993: McDonnell D P; Vegeto E; Gleeson M A
Nuclear hormone receptors as targets for new drug discovery.
Bio/technology (Nature Publishing Company) 1993;11(11):1256-61.
1993: Vegeto E; Shahbaz M M; Wen D X; Goldman M E; O'Malley B W; McDonnell D P
Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.
Molecular endocrinology (Baltimore, Md.) 1993;7(10):1244-55.
1993: Poletti A; Conneely O M; McDonnell D P; Schrader W T; O'Malley B W; Weigel N L
Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites.
Biochemistry 1993;32(37):9563-9.
1993: Santiso-Mere D; Sone T; Hilliard G M; Pike J W; McDonnell D P
Positive regulation of the vitamin D receptor by its cognate ligand in heterologous expression systems.
Molecular endocrinology (Baltimore, Md.) 1993;7(7):833-9.
1993: Nawaz Z; Stancel G M; McDonnell D P; Hyder S M
Creation of an active estrogen-responsive element by a single base change in the flanking sequence of a cellular oncogene: a possible mechanism for hormonal carcinogenesis?
Molecular carcinogenesis 1993;7(2):76-82.
1992: McDonnell D P; Vegeto E; O'Malley B W
Identification of a negative regulatory function for steroid receptors.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10563-7.
1992: Hyder S M; Stancel G M; Nawaz Z; McDonnell D P; Loose-Mitchell D S
Identification of an estrogen response element in the 3'-flanking region of the murine c-fos protooncogene.
The Journal of biological chemistry 1992;267(25):18047-54.
1992: Pham T A; Hwung Y P; Santiso-Mere D; McDonnell D P; O'Malley B W
Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast.
Molecular endocrinology (Baltimore, Md.) 1992;6(7):1043-50.
1992: Vegeto E; Allan G F; Schrader W T; Tsai M J; McDonnell D P; O'Malley B W
The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor.
Cell 1992;69(4):703-13.
1992: Pham T A; McDonnell D P; Tsai M J; O'Malley B W
Modulation of progesterone receptor binding to progesterone response elements by positioned nucleosomes.
Biochemistry 1992;31(5):1570-8.
1992: Nawaz Z; Tsai M J; McDonnell D P; O'Malley B W
Identification of novel steroid-response elements.
Gene expression 1992;2(1):39-47.
1991: Pham T A; Hwung Y P; McDonnell D P; O'Malley B W
Transactivation functions facilitate the disruption of chromatin structure by estrogen receptor derivatives in vivo.
The Journal of biological chemistry 1991;266(27):18179-87.
1991: McDonnell D P; Nawaz Z; Densmore C; Weigel N L; Pham T A; Clark J H; O'Malley B W
High level expression of biologically active estrogen receptor in Saccharomyces cerevisiae.
The Journal of steroid biochemistry and molecular biology 1991;39(3):291-7.
1991: McDonnell D P; Nawaz Z; O'Malley B W
In situ distinction between steroid receptor binding and transactivation at a target gene.
Molecular and cellular biology 1991;11(9):4350-5.
1991: Pham T A; Elliston J F; Nawaz Z; McDonnell D P; Tsai M J; O'Malley B W
Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3125-9.
1990: Liao J; Ozono K; Sone T; McDonnell D P; Pike J W
Vitamin D receptor interaction with specific DNA requires a nuclear protein and 1,25-dihydroxyvitamin D3.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9751-5.
1990: Sone T; McDonnell D P; O'Malley B W; Pike J W
Expression of human vitamin D receptor in Saccharomyces cerevisiae. Purification, properties, and generation of polyclonal antibodies.
The Journal of biological chemistry 1990;265(35):21997-2003.
1990: Power R F; Conneely O M; McDonnell D P; Clark J H; Butt T R; Schrader W T; O'Malley B W
High level expression of a truncated chicken progesterone receptor in Escherichia coli.
The Journal of biological chemistry 1990;265(3):1419-24.
1989: Mak P; McDonnell D P; Weigel N L; Schrader W T; O'Malley B W
Expression of functional chicken oviduct progesterone receptors in yeast (Saccharomyces cerevisiae).
The Journal of biological chemistry 1989;264(36):21613-8.
1989: McDonnell D P; Pike J W; Drutz D J; Butt T R; O'Malley B W
Reconstitution of the vitamin D-responsive osteocalcin transcription unit in Saccharomyces cerevisiae.
Molecular and cellular biology 1989;9(8):3517-23.
1989: McDonnell D P; Scott R A; Kerner S A; O'Malley B W; Pike J W
Functional domains of the human vitamin D3 receptor regulate osteocalcin gene expression.
Molecular endocrinology (Baltimore, Md.) 1989;3(4):635-44.
1988: McDonnell D P; Pike J W; O'Malley B W
The vitamin D receptor: a primitive steroid receptor related to thyroid hormone receptor.
Journal of steroid biochemistry 1988;30(1-6):41-6.
1987: Maxwell B L; McDonnell D P; Conneely O M; Schulz T Z; Greene G L; O'Malley B W
Structural organization and regulation of the chicken estrogen receptor.
Molecular endocrinology (Baltimore, Md.) 1987;1(1):25-35.

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