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Donald McDonnell

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TOP 3
Erik Nelson; Suzanne E Wardell; Donald P McDonnell
The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis.
Julie A Pollock; Donald P McDonnell; Jeff S Jasper; Michelle D Larrea; Dewey G McCafferty
Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners.
Suzanne E Wardell; Dmitri Kazmin; Donald P McDonnell
Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes.

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2013: Erik Nelson; Suzanne E Wardell; Donald P McDonnell
The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis.
Bone 2013;53(1):42-50.
2012: Julie A Pollock; Donald P McDonnell; Jeff S Jasper; Michelle D Larrea; Dewey G McCafferty
Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners.
ACS chemical biology 2012;7(7):1221-31.
2012: Suzanne E Wardell; Dmitri Kazmin; Donald P McDonnell
Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes.
Molecular endocrinology (Baltimore, Md.) 2012;26(7):1235-48.
2011: Erik Nelson; Jeffrey C Rathmell; Michihisa Umetani; Xiaojuan Wang; Carolyn D DuSell; Glenda Evans; Diane Gesty-Palmer; Matthew K Howe; Sundeep Khosla; Ryan Michalek; Donald P McDonnell
The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors.
Endocrinology 2011;152(12):4691-705.
2011: Ryan Michalek; Erik Nelson; Amanda G Nichols; Kristen N Pollizzi; Jonathan D Powell; Mari L Shinohara; William J Zuercher; Ching-Yi Chang; Mary A Dwyer; Valerie A Gerriets; Vincent Giguere; Olga Ilkayeva; Makoto Inoue; Dmitri Kazmin; Donald P McDonnell; Jeffrey C Rathmell
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(45):18348-53.
2011: Ching-Yi Chang; Jeff S Jasper; Dmitri Kazmin; Rebecca Kunder; William J Zuercher; Donald P McDonnell
The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer.
Cancer cell 2011;20(4):500-10.
2011: Suzanne E Wardell; Jeffrey R Marks; Donald P McDonnell
The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy.
Biochemical pharmacology 2011;82(2):122-30.
2011: Daniel E Frigo; Matthew K Howe; Bryan M Wittmann; Abigail M Brunner; Ian Cushman; Qianben Wang; Myles Brown; Anthony R Means; Donald P McDonnell
CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells.
Cancer research 2011;71(2):528-37.
2011: Jun Yang; Ching-yi Chang; Rachid Safi; James Morgan; Donald P McDonnell; Peter J Fuller; Colin D Clyne; Morag J Young
Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display.
Molecular endocrinology (Baltimore, Md.) 2011;25(1):32-43.
2010: Sakiko Kobayashi; James P Stice; Dmitri Kazmin; Bryan M Wittmann; Erin A Kimbrel; Dean P Edwards; Ching-Yi Chang; Donald P McDonnell
Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer.
Molecular endocrinology (Baltimore, Md.) 2010;24(12):2292-302.
2010: Donald P McDonnell; Suzanne E Wardell
The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer.
Current opinion in pharmacology 2010;10(6):620-8.
2010: Mary A Dwyer; James D Joseph; Hilary E Wade; Matthew L Eaton; Rebecca S Kunder; Dmitri Kazmin; Ching-Yi Chang; Donald P McDonnell
WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration.
Cancer research 2010;70(22):9298-308.
2010: Carolyn D DuSell; Erik Nelson; Xiaojuan Wang; Jennifer Abdo; Ulrike I Mödder; Michihisa Umetani; Diane Gesty-Palmer; Norman B Javitt; Sundeep Khosla; Donald P McDonnell
The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.
Endocrinology 2010;151(8):3675-85.
2010: Hilary E Wade; Sakiko Kobayashi; Matthew L Eaton; Michelle S Jansen; Edward K Lobenhofer; Mathieu Lupien; Timothy R Geistlinger; Wencheng Zhu; Joseph R Nevins; Myles Brown; Deborah C Otteson; Donald P McDonnell
Multimodal regulation of E2F1 gene expression by progestins.
Molecular and cellular biology 2010;30(8):1866-77.
2010: Garrett G Muramoto; J Lauren Russell; Rachid Safi; Alice B Salter; Heather A Himburg; Pamela Daher; Sarah K Meadows; Phuong Doan; Robert W Storms; Nelson J Chao; Donald P McDonnell; John P Chute
Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity.
Stem cells (Dayton, Ohio) 2010;28(3):523-34.
2010: John P Chute; Joel R Ross; Donald P McDonnell
Minireview: Nuclear receptors, hematopoiesis, and stem cells.
Molecular endocrinology (Baltimore, Md.) 2010;24(1):1-10.
2010: Carolyn D DuSell; Erik Nelson; Bryan M Wittmann; Jackie A Fretz; Dmitri Kazmin; Russell S Thomas; J Wesley Pike; Donald P McDonnell
Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators.
Molecular endocrinology (Baltimore, Md.) 2010;24(1):33-46.
2009: John D Norris; Ching-Yi Chang; Bryan M Wittmann; Rebecca S Kunder; Huaxia Cui; Daju Fan; James D Joseph; Donald P McDonnell
The homeodomain protein HOXB13 regulates the cellular response to androgens.
Molecular cell 2009;36(3):405-16.
2009: Daniel E Frigo; Andrea B Sherk; Bryan M Wittmann; John D Norris; Qianben Wang; James D Joseph; Aidan P Toner; Myles Brown; Donald P McDonnell
Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro.
Molecular endocrinology (Baltimore, Md.) 2009;23(9):1385-96.
2009: Linda L Grasfeder; Stéphanie Gaillard; Stephen R Hammes; Olga Ilkayeva; Christopher B Newgard; Richard B Hochberg; Mary A Dwyer; Ching-Yi Chang; Donald P McDonnell
Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha.
Molecular endocrinology (Baltimore, Md.) 2009;23(8):1171-82.
2009: James D Joseph; Bryan M Wittmann; Mary A Dwyer; Huaxia Cui; Delita A Dye; Donald P McDonnell; John D Norris
Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):12178-83.
2009: John D Norris; James David Joseph; Andrea Barreto Sherk; Dalia Juzumiene; Philip Stewart Turnbull; Stephen William Rafferty; Huaxia Cui; Erin Anderson; Daju Fan; Delita Arnelle Dye; Xiang Deng; Dmitri Kazmin; Ching-Yi Chang; Timothy M Willson; Donald P McDonnell
Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands.
Chemistry & biology 2009;16(4):452-60.
2009: Rebecca A Stein; Stéphanie Gaillard; Donald P McDonnell
Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells.
The Journal of steroid biochemistry and molecular biology 2009;114(1-2):106-12.
2009: Rachid Safi; Garrett G Muramoto; Alice B Salter; Sarah Meadows; Heather Himburg; Lauren Russell; Pamela Daher; Phuong Doan; Mark D Leibowitz; Nelson J Chao; Donald P McDonnell; John P Chute
Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture.
Molecular endocrinology (Baltimore, Md.) 2009;23(2):188-201.
2008: Rebecca A Stein; Ching-Yi Chang; Dmitri Kazmin; James Way; Thies Schroeder; Melanie Wergin; Mark Dewhirst; Donald P McDonnell
Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer.
Cancer research 2008;68(21):8805-12.
2008: Carolyn D DuSell; Donald P McDonnell
27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling.
Trends in pharmacological sciences 2008;29(10):510-4.
2008: Andrea B Sherk; Daniel E Frigo; Christine G Schnackenberg; Jeffrey D Bray; Nicholas J Laping; Walter Trizna; Marlys Hammond; Jaclyn R Patterson; Scott K Thompson; Dmitri Kazmin; John D Norris; Donald P McDonnell
Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic.
Cancer research 2008;68(18):7475-83.
2008: Daniel E Frigo; Donald P McDonnell
Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation.
Molecular cancer therapeutics 2008;7(3):659-69.
2008: Carolyn D DuSell; Michihisa Umetani; Philip W Shaul; David J Mangelsdorf; Donald P McDonnell
27-hydroxycholesterol is an endogenous selective estrogen receptor modulator.
Molecular endocrinology (Baltimore, Md.) 2008;22(1):65-77.
2007: Bryan M Wittmann; Andrea Sherk; Donald P McDonnell
Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators.
Cancer research 2007;67(19):9549-60.
2007: Niharika B Mettu; Thomas B Stanley; Mary A Dwyer; Michelle S Jansen; John E Allen; Julie M Hall; Donald P McDonnell
The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator-activated receptors.
Molecular endocrinology (Baltimore, Md.) 2007;21(10):2361-77.
2007: Julie M Hall; Donald P McDonnell
The molecular mechanisms underlying the proinflammatory actions of thiazolidinediones in human macrophages.
Molecular endocrinology (Baltimore, Md.) 2007;21(8):1756-68.
2007: Stéphanie Gaillard; Mary A Dwyer; Donald P McDonnell
Definition of the molecular basis for estrogen receptor-related receptor-alpha-cofactor interactions.
Molecular endocrinology (Baltimore, Md.) 2007;21(1):62-76.
2006: Stéphanie Gaillard; Linda L Grasfeder; Christiane L Haeffele; Edward K Lobenhofer; Tzu-Ming Chu; Russell D Wolfinger; Dmitri Kazmin; Timothy R Koves; Deborah M Muoio; Ching-yi Chang; Donald P McDonnell
Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs.
Molecular cell 2006;24(5):797-803.
2006: Donald P McDonnell
Mechanism-based discovery as an approach to identify the next generation of estrogen receptor modulators.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(14):2432-4.
2006: John P Chute; Garrett G Muramoto; John F Whitesides; Michael Colvin; Rachid Safi; Nelson J Chao; Donald P McDonnell
Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11707-12.
2006: Schroeder M Noble; Virginia E Carnahan; Linda B Moore; Tom Luntz; Hongbing Wang; Olivia R Ittoop; Julie B Stimmel; Paula R Davis-Searles; Ryan E Watkins; G Bruce Wisely; Edward LeCluyse; Ashutosh Tripathy; Donald P McDonnell; Matthew R Redinbo
Human PXR forms a tryptophan zipper-mediated homodimer.
Biochemistry 2006;45(28):8579-89.
2006: Dmitri Kazmin; Tatiana Prytkova; C Edgar Cook; Russell D Wolfinger; Tzu-Ming Chu; David Beratan; John D Norris; Ching-yi Chang; Donald P McDonnell
Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators.
Molecular endocrinology (Baltimore, Md.) 2006;20(6):1201-17.
2005: Isaac H Solomon; Janet M Hager; Rachid Safi; Donald P McDonnell; Matthew R Redinbo; Eric ORTLUND
Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity.
Journal of molecular biology 2005;354(5):1091-102.
2005: Rachid Safi; Agnes Kovacic; Stéphanie Gaillard; Yoko Murata; Evan R Simpson; Donald P McDonnell; Colin D Clyne
Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy.
Cancer research 2005;65(24):11762-70.
2005: Julie M Hall; Donald P McDonnell
Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting.
Molecular interventions 2005;5(6):343-57.
2005: Ching-Yi Chang; Jennifer Abdo; Tanya Hartney; Donald P McDonnell
Development of peptide antagonists for the androgen receptor using combinatorial peptide phage display.
Molecular endocrinology (Baltimore, Md.) 2005;19(10):2478-90.
2005: Ya-Ling Wu; Xiaojing Yang; Zhong Ren; Donald P McDonnell; John D Norris; Timothy M Willson; Geoffrey L Greene
Structural basis for an unexpected mode of SERM-mediated ER antagonism.
Molecular cell 2005;18(4):413-24.
2005: Ching-yi Chang; Donald P McDonnell
Androgen receptor-cofactor interactions as targets for new drug discovery.
Trends in pharmacological sciences 2005;26(5):225-8.
2005: Eric ORTLUND; Yoonkwang Lee; Isaac H Solomon; Janet M Hager; Rachid Safi; Yunhee Choi; Ziqiang Guan; Ashutosh Tripathy; Christian R H Raetz; Donald P McDonnell; David D Moore; Matthew R Redinbo
Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP.
Nature structural & molecular biology 2005;12(4):357-63.
2005: Paul L Shaffer; Donald P McDonnell; Daniel T Gewirth
Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor.
Biochemistry 2005;44(7):2678-85.
2005: Donald P McDonnell
The molecular pharmacology of estrogen receptor modulators: implications for the treatment of breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 2):871s-7s.
2005: Dalia Juzumiene; Ching-yi Chang; Daju Fan; Tanya Hartney; John D Norris; Donald P McDonnell
Single-step purification of full-length human androgen receptor.
Nuclear receptor signaling 2005;3():e001.
2004: Donald P McDonnell
The molecular determinants of estrogen receptor pharmacology.
Maturitas 2004;48 Suppl 1():S7-12.
2004: Michelle S Jansen; Susan C Nagel; Phillippa J Miranda; Edward K Lobenhofer; Cynthia A Afshari; Donald P McDonnell
Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):7199-204.
2003: Ganesan Sathya; Ching-yi Chang; Dmitri Kazmin; C Edgar Cook; Donald P McDonnell
Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion.
Cancer research 2003;63(22):8029-36.
2003: Donald P McDonnell
Mining the complexities of the estrogen signaling pathways for novel therapeutics.
Endocrinology 2003;144(10):4237-40.
2003: Heather L Rincavage; Donald P McDonnell; Cynthia M Kuhn
Expression of functional estrogen receptor beta in locus coeruleus-derived Cath.a cells.
Endocrinology 2003;144(7):2829-35.
2003: Ching-yi Chang; John D Norris; Michelle Jansen; Huey-Jing Huang; Donald P McDonnell
Application of random peptide phage display to the study of nuclear hormone receptors.
Methods in enzymology 2003;364():118-42.
2002: Huey-Jing Huang; John D Norris; Donald P McDonnell
Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists.
Molecular endocrinology (Baltimore, Md.) 2002;16(8):1778-92.
2002: Ganesan Sathya; Michelle S Jansen; Susan C Nagel; C Edgar Cook; Donald P McDonnell
Identification and characterization of novel estrogen receptor-beta-sparing antiprogestins.
Endocrinology 2002;143(8):3071-82.
2002: Donald P McDonnell; Ashini Wijayaratne; Ching-yi Chang; John D Norris
Elucidation of the molecular mechanism of action of selective estrogen receptor modulators.
The American journal of cardiology 2002;90(1A):35F-43F.
2002: Xiaolin Li; Erin A Kimbrel; Daniel J Kenan; Donald P McDonnell
Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation.
Molecular endocrinology (Baltimore, Md.) 2002;16(7):1482-91.
2002: Xiaolin Li; Donald P McDonnell
The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.
Molecular and cellular biology 2002;22(11):3663-73.
2002: Donald P McDonnell; John D Norris
Connections and regulation of the human estrogen receptor.
Science (New York, N.Y.) 2002;296(5573):1642-4.
2002: Ching-Yi Chang; Donald P McDonnell
Evaluation of ligand-dependent changes in AR structure using peptide probes.
Molecular endocrinology (Baltimore, Md.) 2002;16(4):647-60.
2002: John D Norris; Daju Fan; Andrea Sherk; Donald P McDonnell
A negative coregulator for the human ER.
Molecular endocrinology (Baltimore, Md.) 2002;16(3):459-68.
2002: Donald P McDonnell; Caroline E Connor; Ashini Wijayaratne; Ching-Yi Chang; John D Norris
Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators.
Recent progress in hormone research 2002;57():295-316.
2001: Ching-yi Chang; P J Walther; Donald P McDonnell
Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer.
Cancer research 2001;61(24):8712-7.
2001: Donald P McDonnell; Ching-Yi Chang; John D Norris
Capitalizing on the complexities of estrogen receptor pharmacology in the quest for the perfect SERM.
Annals of the New York Academy of Sciences 2001;949():16-35.
2001: Susan C Nagel; J L Hagelbarger; Donald P McDonnell
Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics.
Endocrinology 2001;142(11):4721-8.
2001: Ashini Wijayaratne; Donald P McDonnell
The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators.
The Journal of biological chemistry 2001;276(38):35684-92.
2001: M H Hamilton; Irina Tcherepanova; Jon M Huibregtse; Donald P McDonnell
Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates.
The Journal of biological chemistry 2001;276(28):26324-31.
2001: C E Connor; John D Norris; Gloria Broadwater; Timothy M Willson; M M Gottardis; Mark Dewhirst; Donald P McDonnell
Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor.
Cancer research 2001;61(7):2917-22.
2001: John D Norris; C Chang; Donald P McDonnell
Estrogen receptor-cofactor interactions as targets for novel drug discovery.
Ernst Schering Research Foundation workshop 2001;(34):181-201.
2000: Julie M Hall; Ching-Yi Chang; Donald P McDonnell
Development of peptide antagonists that target estrogen receptor beta-coactivator interactions.
Molecular endocrinology (Baltimore, Md.) 2000;14(12):2010-23.
2000: Donald P McDonnell; C Y Chang; John D Norris
Development of peptide antagonists that target estrogen receptor-cofactor interactions.
The Journal of steroid biochemistry and molecular biology 2000;74(5):327-35.
2000: Kevin W Gaido; SC Maness; Donald P McDonnell; Shangara S Dehal; David Kupfer; Stephen Safe
Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies.
Molecular pharmacology 2000;58(4):852-8.
2000: Irina Tcherepanova; Pere Puigserver; John D Norris; Bruce M Spiegelman; Donald P McDonnell
Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1.
The Journal of biological chemistry 2000;275(21):16302-8.
2000: Paloma H Giangrande; E A Kimbrel; D P Edwards; Donald P McDonnell
The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding.
Molecular and cellular biology 2000;20(9):3102-15.
2000: Donald P McDonnell
Selective estrogen receptor modulators (SERMs): A first step in the development of perfect hormone replacement therapy regimen.
Journal of the Society for Gynecologic Investigation 2000;7(1 Suppl):S10-5.
1999: Ashini Wijayaratne; Susan C Nagel; LA Paige; Dale J Christensen; John D Norris; DM Fowlkes; Donald P McDonnell
Comparative analyses of mechanistic differences among antiestrogens.
Endocrinology 1999;140(12):5828-40.
1999: Kevin W Gaido; LS Leonard; SC Maness; J M Hall; Donald P McDonnell; B Saville; Stephen Safe
Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta.
Endocrinology 1999;140(12):5746-53.
1999: Julie M Hall; Donald P McDonnell
The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens.
Endocrinology 1999;140(12):5566-78.
1999: C y Chang; John D Norris; H Grøn; LA Paige; Paul T Hamilton; Daniel J Kenan; DM Fowlkes; Donald P McDonnell
Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta.
Molecular and cellular biology 1999;19(12):8226-39.
1999: John D Norris; LA Paige; Dale J Christensen; Ching-Yi Chang; M R Huacani; D Fan; Paul T Hamilton; DM Fowlkes; Donald P McDonnell
Peptide antagonists of the human estrogen receptor.
Science (New York, N.Y.) 1999;285(5428):744-6.
1999: T Improta-Brears; A Richard Whorton; F Codazzi; John D York; Tobias meyer; Donald P McDonnell
Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4686-91.
1999: LA Paige; Dale J Christensen; H Grøn; John D Norris; Elizabeth B Gottlin; K M Padilla; Ching-Yi Chang; L M Ballas; Paul T Hamilton; Donald P McDonnell; DM Fowlkes
Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3999-4004.
1999: BL Wagner; G Pollio; Paloma H Giangrande; JC Webster; M Breslin; D E Mais; C Edgar Cook; W V Vedeckis; John A Cidlowski; Donald P McDonnell
The novel progesterone receptor antagonists RTI 3021-012 and RTI 3021-022 exhibit complex glucocorticoid receptor antagonist activities: implications for the development of dissociated antiprogestins.
Endocrinology 1999;140(3):1449-58.
1999: P H Giangrande; Donald P McDonnell
The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene.
Recent progress in hormone research 1999;54():291-313; discussion 313-4.
1998: J C Gould; LS Leonard; SC Maness; BL Wagner; K Conner; Timothy R Zacharewski; Stephen Safe; Donald P McDonnell; Kevin W Gaido
Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol.
Molecular and cellular endocrinology 1998;142(1-2):203-14.
1998: SC Maness; Donald P McDonnell; Kevin W Gaido
Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells.
Toxicology and applied pharmacology 1998;151(1):135-42.
1998: John D Norris; D Fan; M R Stallcup; Donald P McDonnell
Enhancement of estrogen receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation function 2 in determining estrogen receptor pharmacology.
The Journal of biological chemistry 1998;273(12):6679-88.
1998: BL Wagner; John D Norris; T A Knotts; Nancy L Weigel; Donald P McDonnell
The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor.
Molecular and cellular biology 1998;18(3):1369-78.
1997: P H Giangrande; G Pollio; Donald P McDonnell
Mapping and characterization of the functional domains responsible for the differential activity of the A and B isoforms of the human progesterone receptor.
The Journal of biological chemistry 1997;272(52):32889-900.
1997: K Ramamoorthy; CA Vyhlidal; Fen Wang; I Chen; Stephen Safe; Donald P McDonnell; L S Leonard; Kevin W Gaido
Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol.
Toxicology and applied pharmacology 1997;147(1):93-100.
1997: Timothy M Willson; John D Norris; BL Wagner; I Asplin; P Baer; H R Brown; Stacey A Jones; Brad R Henke; H Sauls; S Wolfe; DC Morris; Donald P McDonnell
Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone.
Endocrinology 1997;138(9):3901-11.
1997: John D Norris; Daju Fan; S A Kerner; Donald P McDonnell
Identification of a third autonomous activation domain within the human estrogen receptor.
Molecular endocrinology (Baltimore, Md.) 1997;11(6):747-54.
1997: K Ramamoorthy; Fen Wang; I C Chen; John D Norris; Donald P McDonnell; L S Leonard; Kevin W Gaido; W P Bocchinfuso; K S Korach; Stephen Safe
Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism.
Endocrinology 1997;138(4):1520-7.
1997: Kevin W Gaido; LS Leonard; S Lovell; J C Gould; D Babaï; Christopher Portier; Donald P McDonnell
Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay.
Toxicology and applied pharmacology 1997;143(1):205-12.
1997: K Ramamoorthy; Fen Wang; I C Chen; Stephen Safe; John D Norris; Donald P McDonnell; Kevin W Gaido; W P Bocchinfuso; K S Korach
Potency of combined estrogenic pesticides.
Science (New York, N.Y.) 1997;275(5298):405-6.
1997: Donald P McDonnell; John D Norris
Analysis of the molecular pharmacology of estrogen receptor agonists and antagonists provides insights into the mechanism of action of estrogen in bone.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 1997;7 Suppl 1():S29-34.
1996: J D Fan; BL Wagner; Donald P McDonnell
Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity.
Molecular endocrinology (Baltimore, Md.) 1996;10(12):1605-16.
1996: BL Wagner; G Pollio; S Leonhardt; Mansukh C Wani; D Y Lee; M O Imhof; D P Edwards; C E Cook; Donald P McDonnell
16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8739-44.
1996: M O Imhof; Donald P McDonnell
Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors.
Molecular and cellular biology 1996;16(6):2594-605.
1995: J Norris; D Fan; C Aleman; Jeffrey R Marks; P Andrew Futreal; Roger W Wiseman; J Dirk Iglehart; P L Deininger; Donald P McDonnell
Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers.
The Journal of biological chemistry 1995;270(39):22777-82.
1995: Donald P McDonnell; S L Dana; P A Hoener; B A Lieberman; M O Imhof; R B Stein
Cellular mechanisms which distinguish between hormone- and antihormone-activated estrogen receptor.
Annals of the New York Academy of Sciences 1995;761():121-37.
1995: Donald P McDonnell; D L Clemm; T Hermann; M E Goldman; J W Pike
Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.
Molecular endocrinology (Baltimore, Md.) 1995;9(6):659-69.
1995: D L Clemm; B L Macy; D Santiso-Mere; Donald P McDonnell
Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor.
The Journal of steroid biochemistry and molecular biology 1995;53(1-6):487-95.
1994: D X Wen; Y F Xu; D E Mais; M E Goldman; Donald P McDonnell
The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells.
Molecular and cellular biology 1994;14(12):8356-64.
1994: Donald P McDonnell; D L Clemm; M O Imhof
Definition of the cellular mechanisms which distinguish between hormone and antihormone activated steroid receptors.
Seminars in cancer biology 1994;5(5):327-36.
1994: S L Dana; P A Hoener; D A Wheeler; C B Lawrence; Donald P McDonnell
Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells.
Molecular endocrinology (Baltimore, Md.) 1994;8(9):1193-207.
1994: Donald P McDonnell; M E Goldman
RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism.
The Journal of biological chemistry 1994;269(16):11945-9.
1994: Donald P McDonnell; M M Shahbaz; Elisabetta Vegeto; M E Goldman
The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity.
The Journal of steroid biochemistry and molecular biology 1994;48(5-6):425-32.
1994: M T Tzukerman; A Esty; D Santiso-Mere; P Danielian; M G Parker; R B Stein; J W Pike; Donald P McDonnell
Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.
Molecular endocrinology (Baltimore, Md.) 1994;8(1):21-30.
1993: Donald P McDonnell; B Clevenger; S Dana; D Santiso-Mere; M T Tzukerman; M A Gleeson
The mechanism of action of steroid hormones: a new twist to an old tale.
Journal of clinical pharmacology 1993;33(12):1165-72.
1993: Donald P McDonnell; Elisabetta Vegeto; M A Gleeson
Nuclear hormone receptors as targets for new drug discovery.
Bio/technology (Nature Publishing Company) 1993;11(11):1256-61.
1993: Elisabetta Vegeto; M M Shahbaz; D X Wen; M E Goldman; Bert W O'Malley; Donald P McDonnell
Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.
Molecular endocrinology (Baltimore, Md.) 1993;7(10):1244-55.
1993: A Poletti; O M Conneely; Donald P McDonnell; W T Schrader; Bert W O'Malley; Nancy L Weigel
Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites.
Biochemistry 1993;32(37):9563-9.
1993: D Santiso-Mere; T Sone; G M Hilliard; J W Pike; Donald P McDonnell
Positive regulation of the vitamin D receptor by its cognate ligand in heterologous expression systems.
Molecular endocrinology (Baltimore, Md.) 1993;7(7):833-9.
1993: Zafar Nawaz; George M Stancel; Donald P McDonnell; Salman M Hyder
Creation of an active estrogen-responsive element by a single base change in the flanking sequence of a cellular oncogene: a possible mechanism for hormonal carcinogenesis?
Molecular carcinogenesis 1993;7(2):76-82.
1992: Donald P McDonnell; Elisabetta Vegeto; Bert W O'Malley
Identification of a negative regulatory function for steroid receptors.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10563-7.
1992: Salman M Hyder; George M Stancel; Zafar Nawaz; Donald P McDonnell; D S Loose-Mitchell
Identification of an estrogen response element in the 3'-flanking region of the murine c-fos protooncogene.
The Journal of biological chemistry 1992;267(25):18047-54.
1992: T A Pham; Y P Hwung; D Santiso-Mere; Donald P McDonnell; Bert W O'Malley
Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast.
Molecular endocrinology (Baltimore, Md.) 1992;6(7):1043-50.
1992: Elisabetta Vegeto; G F Allan; W T Schrader; Ming-Jer Tsai; Donald P McDonnell; Bert W O'Malley
The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor.
Cell 1992;69(4):703-13.
1992: T A Pham; Donald P McDonnell; Ming-Jer Tsai; Bert W O'Malley
Modulation of progesterone receptor binding to progesterone response elements by positioned nucleosomes.
Biochemistry 1992;31(5):1570-8.
1992: Zafar Nawaz; Ming-Jer Tsai; Donald P McDonnell; Bert W O'Malley
Identification of novel steroid-response elements.
Gene expression 1992;2(1):39-47.
1991: T A Pham; Y P Hwung; Donald P McDonnell; Bert W O'Malley
Transactivation functions facilitate the disruption of chromatin structure by estrogen receptor derivatives in vivo.
The Journal of biological chemistry 1991;266(27):18179-87.
1991: Donald P McDonnell; Zafar Nawaz; C Densmore; Nancy L Weigel; T A Pham; J H Clark; Bert W O'Malley
High level expression of biologically active estrogen receptor in Saccharomyces cerevisiae.
The Journal of steroid biochemistry and molecular biology 1991;39(3):291-7.
1991: Donald P McDonnell; Zafar Nawaz; Bert W O'Malley
In situ distinction between steroid receptor binding and transactivation at a target gene.
Molecular and cellular biology 1991;11(9):4350-5.
1991: T A Pham; J F Elliston; Zafar Nawaz; Donald P McDonnell; Ming-Jer Tsai; Bert W O'Malley
Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3125-9.
1990: T Sone; Donald P McDonnell; Bert W O'Malley; J W Pike
Expression of human vitamin D receptor in Saccharomyces cerevisiae. Purification, properties, and generation of polyclonal antibodies.
The Journal of biological chemistry 1990;265(35):21997-2003.
1990: J Liao; K Ozono; T Sone; Donald P McDonnell; J W Pike
Vitamin D receptor interaction with specific DNA requires a nuclear protein and 1,25-dihydroxyvitamin D3.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9751-5.
1990: R F Power; Orla M Conneely; Donald P McDonnell; J H Clark; T R Butt; W T Schrader; Bert W O'Malley
High level expression of a truncated chicken progesterone receptor in Escherichia coli.
The Journal of biological chemistry 1990;265(3):1419-24.
1989: P Mak; Donald P McDonnell; Nancy L Weigel; W T Schrader; Bert W O'Malley
Expression of functional chicken oviduct progesterone receptors in yeast (Saccharomyces cerevisiae).
The Journal of biological chemistry 1989;264(36):21613-8.
1989: Donald P McDonnell; J W Pike; D J Drutz; T R Butt; Bert W O'Malley
Reconstitution of the vitamin D-responsive osteocalcin transcription unit in Saccharomyces cerevisiae.
Molecular and cellular biology 1989;9(8):3517-23.
1989: Donald P McDonnell; R A Scott; S A Kerner; Bert W O'Malley; J W Pike
Functional domains of the human vitamin D3 receptor regulate osteocalcin gene expression.
Molecular endocrinology (Baltimore, Md.) 1989;3(4):635-44.
1988: Donald P McDonnell; J W Pike; Bert W O'Malley
The vitamin D receptor: a primitive steroid receptor related to thyroid hormone receptor.
Journal of steroid biochemistry 1988;30(1-6):41-6.
1987: B L Maxwell; Donald P McDonnell; Orla M Conneely; T Z Schulz; G L Greene; Bert W O'Malley
Structural organization and regulation of the chicken estrogen receptor.
Molecular endocrinology (Baltimore, Md.) 1987;1(1):25-35.