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John McDonough

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Jacob W Skovira; Tsung-Ming Shih; John H McDonough
Neuropharmacological specificity of brain structures involved in soman-induced seizures.
John C O'Donnell; John H McDonough; Tsung-Ming Shih
In vivo microdialysis and electroencephalographic activity in freely moving guinea pigs exposed to organophosphorus nerve agents sarin and VX: analysis of acetylcholine and glutamate.
Tsung-Ming Shih; John A Guarisco; Todd M Myers; Robert K Kan; John H McDonough
The oxime pro-2-PAM provides minimal protection against the CNS effects of the nerve agents sarin, cyclosarin, and VX in guinea pigs.

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All Publications

2012: Jacob W Skovira; Tsung-Ming Shih; John H McDonough
Neuropharmacological specificity of brain structures involved in soman-induced seizures.
Neurotoxicology 2012;33(3):463-8.
2011: John C O'Donnell; John H McDonough; Tsung-Ming Shih
In vivo microdialysis and electroencephalographic activity in freely moving guinea pigs exposed to organophosphorus nerve agents sarin and VX: analysis of acetylcholine and glutamate.
Archives of toxicology 2011;85(12):1607-16.
2011: Tsung-Ming Shih; John A Guarisco; Todd M Myers; Robert K Kan; John H McDonough
The oxime pro-2-PAM provides minimal protection against the CNS effects of the nerve agents sarin, cyclosarin, and VX in guinea pigs.
Toxicology mechanisms and methods 2011;21(1):53-62.
2010: John C O'Donnell; Cindy Acon-Chen; John H McDonough; Tsung-Ming Shih
Comparison of extracellular striatal acetylcholine and brain seizure activity following acute exposure to the nerve agents cyclosarin and tabun in freely moving guinea pigs.
Toxicology mechanisms and methods 2010;20(9):600-8.
2010: Jacob W Skovira; John C O'Donnell; Irwin Koplovitz; Robert K Kan; John H McDonough; Tsung-Ming Shih
Reactivation of brain acetylcholinesterase by monoisonitrosoacetone increases the therapeutic efficacy against nerve agents in guinea pigs.
Chemico-biological interactions 2010;187(1-3):318-24.
2010: Tsung-Ming Shih; Jacob W Skovira; John C O'Donnell; John H McDonough
In vivo reactivation by oximes of inhibited blood, brain and peripheral tissue cholinesterase activity following exposure to nerve agents in guinea pigs.
Chemico-biological interactions 2010;187(1-3):207-14.
2010: John H McDonough; Joseph D McMonagle; Tsung-Ming Shih
Time-dependent reduction in the anticonvulsant effectiveness of diazepam against soman-induced seizures in guinea pigs.
Drug and chemical toxicology 2010;33(3):279-83.
2010: Benedict R Capacio; B Dusick; JR Smith; John H McDonough; Tsung-Ming Shih
A liquid chromatographic-mass spectrometric (LC-MS) method for the analysis of the bis-pyridinium oxime ICD-585 in plasma: application in a guinea pig model.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(17-18):1420-5.
2010: John C O'Donnell; John H McDonough; Tsung-Ming Shih
Changes in extracellular striatal acetylcholine and brain seizure activity following acute exposure to nerve agents in freely moving guinea pigs.
Toxicology mechanisms and methods 2010;20(3):143-52.
2010: Jacob W Skovira; John H McDonough; Tsung-Ming Shih
Protection against sarin-induced seizures in rats by direct brain microinjection of scopolamine, midazolam or MK-801.
Journal of molecular neuroscience : MN 2010;40(1-2):56-62.
2010: Tsung-Ming Shih; Jacob W Skovira; John C O'Donnell; John H McDonough
Treatment with tertiary oximes prevents seizures and improves survival following sarin intoxication.
Journal of molecular neuroscience : MN 2010;40(1-2):63-9.
2009: Tsung-Ming Shih; Jacob W Skovira; John H McDonough
Effects of 4-pyridine aldoxime on nerve agent-inhibited acetylcholinesterase activity in guinea pigs.
Archives of toxicology 2009;83(12):1083-9.
2007: Christopher E Whalley; Jeffrey M McGuire; Dennis B Miller; Edward M Jakubowski; Robert J Mioduszewski; Sandra A Thomson; Lucille A Lumley; John H McDonough; Tsung-Ming Shih
Kinetics of sarin (GB) following a single sublethal inhalation exposure in the guinea pig.
Inhalation toxicology 2007;19(8):667-81.
2007: Kenneth E Despain; John H McDonough; Joseph D McMonagle; Maura J McGinley; Jackie Evans
The Toxicity of Soman in the African Green Monkey (Chlorocebus aethiops).
Toxicology mechanisms and methods 2007;17(5):255-64.
2007: Tsung-Ming Shih; Tami C Rowland; John H McDonough
Anticonvulsants for nerve agent-induced seizures: The influence of the therapeutic dose of atropine.
The Journal of pharmacology and experimental therapeutics 2007;320(1):154-61.
2006: Tsung-Ming Shih; S W Hulet; John H McDonough
The effects of repeated low-dose sarin exposure.
Toxicology and applied pharmacology 2006;215(2):119-34.
2005: Tsung-Ming Shih; Robert K Kan; John H McDonough
In vivo cholinesterase inhibitory specificity of organophosphorus nerve agents.
Chemico-biological interactions 2005;157-158():293-303.
2004: Benedict R Capacio; CE Byers; K A Merk; JR Smith; John H McDonough
Pharmacokinetic studies of intramuscular midazolam in guinea pigs challenged with soman.
Drug and chemical toxicology 2004;27(2):95-110.
2004: John H McDonough; Alex Benjamin; Joseph D McMonagle; Tami Rowland; Tsung-Ming Shih
Effects of fosphenytoin on nerve agent-induced status epilepticus.
Drug and chemical toxicology 2004;27(1):27-39.
2003: Tsung-Ming Shih; Steven M Duniho; John H McDonough
Control of nerve agent-induced seizures is critical for neuroprotection and survival.
Toxicology and applied pharmacology 2003;188(2):69-80.
2003: Benedict R Capacio; CE Byers; S T Caro; John H McDonough
Pharmacokinetics of intramuscularly administered biperiden in guinea pigs challenged with soman.
Drug and chemical toxicology 2003;26(1):1-13.
2002: S W Hulet; John H McDonough; Tsung-Ming Shih
The dose-response effects of repeated subacute sarin exposure on guinea pigs.
Pharmacology, biochemistry, and behavior 2002;72(4):835-45.
2001: Benedict R Capacio; Christopher E Whalley; CE Byers; John H McDonough
Intramuscular diazepam pharmacokinetics in soman-exposed guinea pigs.
Journal of applied toxicology : JAT 2001;21 Suppl 1():S67-74.
2000: Tsung-Ming Shih; John H McDonough
Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication.
Archives of toxicology 2000;74(3):165-72.
2000: M C Ross; L D Zoeffel; Joseph D McMonagle; John H McDonough
Isoflurane anesthesia for guinea pigs (Cavia porcella) in a stereotaxic surgical apparatus.
Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science 2000;39(2):43-6.
2000: John H McDonough; L D Zoeffel; Joseph D McMonagle; T L Copeland; C D Smith; Tsung-Ming Shih
Anticonvulsant treatment of nerve agent seizures: anticholinergics versus diazepam in soman-intoxicated guinea pigs.
Epilepsy research 2000;38(1):1-14.
1999: John H McDonough; Joseph D McMonagle; T Copeland; D Zoeffel; Tsung-Ming Shih
Comparative evaluation of benzodiazepines for control of soman-induced seizures.
Archives of toxicology 1999;73(8-9):473-8.
1999: Tsung-Ming Shih; John H McDonough
Organophosphorus nerve agents-induced seizures and efficacy of atropine sulfate as anticonvulsant treatment.
Pharmacology, biochemistry, and behavior 1999;64(1):147-53.
1998: John H McDonough; T R Clark; T W Slone; D Zoeffel; K Brown; S Kim; C D Smith
Neural lesions in the rat and their relationship to EEG delta activity following seizures induced by the nerve agent soman.
Neurotoxicology 1998;19(3):381-91.
1997: John H McDonough; Tsung-Ming Shih
Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology.
Neuroscience and biobehavioral reviews 1997;21(5):559-79.
1997: Tsung-Ming Shih; John H McDonough
Neurochemical mechanisms in soman-induced seizures.
Journal of applied toxicology : JAT 1997;17(4):255-64.
1996: Guy Lallement; T M Shih; I Pernot-Marino; Dominique Baubichon; Annie Foquin; John H McDonough
The role of nitric oxide in soman-induced seizures, neuropathology, and lethality.
Pharmacology, biochemistry, and behavior 1996;54(4):731-7.
1995: John H McDonough; T M Shih
A study of the N-methyl-D-aspartate antagonistic properties of anticholinergic drugs.
Pharmacology, biochemistry, and behavior 1995;51(2-3):249-53.
1995: John H McDonough; L W Dochterman; C D Smith; T M Shih
Protection against nerve agent-induced neuropathology, but not cardiac pathology, is associated with the anticonvulsant action of drug treatment.
Neurotoxicology 1995;16(1):123-32.
1993: John H McDonough; T M Shih
Pharmacological modulation of soman-induced seizures.
Neuroscience and biobehavioral reviews 1993;17(2):203-15.
1990: T M Shih; D M Penetar; John H McDonough; J A Romano; J M King
Age-related differences in soman toxicity and in blood and brain regional cholinesterase activity.
Brain research bulletin 1990;24(3):429-36.
1983: D M Penetar; John H McDonough
Effects of cholinergic drugs on delayed match-to-sample performance of rhesus monkeys.
Pharmacology, biochemistry, and behavior 1983;19(6):963-7.