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Raymond Baumann

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Rui Zhu; Krishnamurthy Shyam; Raymond P Baumann; Kimiko Ishiguro; Eric Patridge; Philip G Penketh; Alan C Sartorelli
Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells.
Rui Zhu; Krishnamurthy Shyam; Raymond P Baumann; Philip G Penketh; Alan C Sartorelli
Hypoxia-selective O6-alkylguanine-DNA alkyltransferase inhibitors: design, synthesis, and evaluation of 6-(benzyloxy)-2-(aryldiazenyl)-9H-purines as prodrugs of O6-benzylguanine.
Rui Zhu; Helen A Seow; Krishnamurthy Shyam; Raymond P Baumann; Kimiko Ishiguro; Philip G Penketh; Alan C Sartorelli
Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase.

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2013: Rui Zhu; Krishnamurthy Shyam; Raymond P Baumann; Kimiko Ishiguro; Eric Patridge; Philip G Penketh; Alan C Sartorelli
Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells.
Bioorganic & medicinal chemistry letters 2013;23(6):1853-9.
2013: Rui Zhu; Krishnamurthy Shyam; Raymond P Baumann; Philip G Penketh; Alan C Sartorelli
Hypoxia-selective O6-alkylguanine-DNA alkyltransferase inhibitors: design, synthesis, and evaluation of 6-(benzyloxy)-2-(aryldiazenyl)-9H-purines as prodrugs of O6-benzylguanine.
Journal of medicinal chemistry 2013;56(3):1355-9.
2012: Rui Zhu; Helen A Seow; Krishnamurthy Shyam; Raymond P Baumann; Kimiko Ishiguro; Philip G Penketh; Alan C Sartorelli
Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase.
Bioorganic & medicinal chemistry letters 2012;22(19):6242-7.
2012: Eric V Patridge; Philip G Penketh; Raymond P Baumann; Emma S E Eriksson; Leif A Eriksson; Krishnamurthy Shyam; Rui Zhu; Alan C Sartorelli
7-Nitro-4-(phenylthio)benzofurazan is a potent generator of superoxide and hydrogen peroxide.
Archives of toxicology 2012;86(10):1613-25.
2012: Philip G Penketh; Raymond P Baumann; Kimiko Ishiguro; Eric V Patridge; Krishnamurthy Shyam; Rui Zhu; Alan C Sartorelli
A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditions.
Chemical biology & drug design 2012;80(2):279-90.
2012: Sara Rockwell; Helen A Seow; Krishnamurthy Shyam; Oluwatoyin M Akintujoye; Raymond P Baumann; Peter M Glazer; Kimiko Ishiguro; Yanfeng Liu; Philip G Penketh; Alan C Sartorelli
Preclinical evaluation of Laromustine for use in combination with radiation therapy in the treatment of solid tumors.
International journal of radiation biology 2012;88(3):277-85.
2011: Rui Zhu; Krishnamurthy Shyam; Raymond P Baumann; Mao-Chin Liu; Mei-Zhen Luo; Philip G Penketh; Alan C Sartorelli
4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine.
Journal of medicinal chemistry 2011;54(21):7720-8.
2011: Philip G Penketh; Krishnamurthy Shyam; Hugh S Williamson; Rui Zhu; Raymond P Baumann; Emma S E Eriksson; Leif A Eriksson; Kimiko Ishiguro; Alan C Sartorelli
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119): a cytotoxic prodrug with two stable conformations differing in biological and physical properties.
Chemical biology & drug design 2011;78(4):513-26.
2011: Raymond P Baumann; Kimiko Ishiguro; Philip G Penketh; Krishnamurthy Shyam; Rui Zhu; Alan C Sartorelli
KS900: A hypoxia-directed, reductively activated methylating antitumor prodrug that selectively ablates O(6)-alkylguanine-DNA alkyltransferase in neoplastic cells.
Biochemical pharmacology 2011;81(10):1201-10.
2010: Kimiko Ishiguro; Yong-Lian Zhu; Krishnamurthy Shyam; Philip G Penketh; Raymond P Baumann; Alan C Sartorelli
Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase.
Biochemical pharmacology 2010;80(9):1317-25.
2010: Raymond P Baumann; Philip G Penketh; Kimiko Ishiguro; Krishnamurthy Shyam; Yong L Zhu; Alan C Sartorelli
Reductive activation of the prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively occurs in oxygen-deficient cells and overcomes O(6)-alkylguanine-DNA alkyltransferase mediated KS119 tumor cell resistance.
Biochemical pharmacology 2010;79(11):1553-61.
2008: Philip G Penketh; Raymond P Baumann; Kimiko Ishiguro; Krishnamurthy Shyam; Helen A Seow; Alan C Sartorelli
Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species.
Leukemia research 2008;32(10):1546-53.
2005: Raymond P Baumann; Helen A Seow; Krishnamurthy Shyam; Philip G Penketh; Alan C Sartorelli
The antineoplastic efficacy of the prodrug Cloretazine is produced by the synergistic interaction of carbamoylating and alkylating products of its activation.
Oncology research 2005;15(6):313-25.
2004: Philip G Penketh; Krishnamurthy Shyam; Raymond P Baumann; Joanna S Remack; Thomas P Brent; Alan C Sartorelli
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): I. Direct inhibition of O6-alkylguanine-DNA alkyltransferase (AGT) by electrophilic species generated by decomposition.
Cancer chemotherapy and pharmacology 2004;53(4):279-87.
2004: Raymond P Baumann; Krishnamurthy Shyam; Philip G Penketh; Joanna S Remack; Thomas P Brent; Alan C Sartorelli
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): II. Role of O6-alkylguanine-DNA alkyltransferase in cytotoxicity.
Cancer chemotherapy and pharmacology 2004;53(4):288-95.
2004: Helen A Seow; Philip G Penketh; Raymond P Baumann; Alan C Sartorelli
Bioactivation and resistance to mitomycin C.
Methods in enzymology 2004;382():221-33.
2002: Raymond P Baumann; David H Sherman; Alan C Sartorelli
Novel selection marker for mammalian cell transfection.
BioTechniques 2002;32(5):1030, 1032, 1034 passim.
2001: Raymond P Baumann; William F Hodnick; Helen A Seow; Michael F Belcourt; S Rockwell; David H Sherman; Alan C Sartorelli
Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells.
Cancer research 2001;61(21):7770-6.