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Grant McFadden

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Oncolytic Virotherapy

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Co-Publications
Name
31
Barrett, John
17
Lucas, Alexandra
15
Nash, Piers
13
Werden, Steven
12
Lalani, Alshad
12
Barry, Michele
11
Dai, Erbin
11
Liu, Liying
11
Graham, K
11
Seet, Bruce
11
Stanford, Marianne
11
Rahman, Masmudur
10
Nazarian, Steven
9
Mossman, Karen
9
Johnston, James

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Publications

TOP 3
Werden Steven J; Lanchbury Jerry; Shattuck Donna; Neff Chris; Dufford Max; McFadden Grant
The myxoma virus m-t5 ankyrin repeat host range protein is a novel adaptor that coordinately links the cellular signaling pathways mediated by Akt and Skp1 in virus-infected cells.
Rahman Masmudur M; Mohamed Mohamed R; Kim Manbok; Smallwood Sherin; McFadden Grant
Co-regulation of NF-kappaB and inflammasome-mediated inflammatory responses by myxoma virus pyrin domain-containing protein m013.
Mohamed Mohamed Ragaa; McFadden Grant
NFkB inhibitors: strategies from poxviruses.

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All Publications

2009: Werden Steven J; Lanchbury Jerry; Shattuck Donna; Neff Chris; Dufford Max; McFadden Grant
The myxoma virus m-t5 ankyrin repeat host range protein is a novel adaptor that coordinately links the cellular signaling pathways mediated by Akt and Skp1 in virus-infected cells.
Journal of virology 2009;83(23):12068-83.
2009: Rahman Masmudur M; Mohamed Mohamed R; Kim Manbok; Smallwood Sherin; McFadden Grant
Co-regulation of NF-kappaB and inflammasome-mediated inflammatory responses by myxoma virus pyrin domain-containing protein m013.
PLoS pathogens 2009;5(10):e1000635.
2009: Mohamed Mohamed Ragaa; McFadden Grant
NFkB inhibitors: strategies from poxviruses.
Cell cycle (Georgetown, Tex.) 2009;8(19):3125-32.
2009: McFadden Grant; Mohamed Mohamed R; Rahman Masmudur M; Bartee Eric
Cytokine determinants of viral tropism.
Nature reviews. Immunology 2009;9(9):645-55.
2009: Bartee Eric; McFadden Grant
Human cancer cells have specifically lost the ability to induce the synergistic state caused by tumor necrosis factor plus interferon-beta.
Cytokine 2009;47(3):199-205.
2009: Zhang Leiliang; Villa Nancy Y; Rahman Masmudur M; Smallwood Sherin; Shattuck Donna; Neff Chris; Dufford Max; Lanchbury Jerry S; Labaer Joshua; McFadden Grant
Analysis of vaccinia virus-host protein-protein interactions: validations of yeast two-hybrid screenings.
Journal of proteome research 2009;8(9):4311-8.
2009: Mohamed Mohamed Ragaa; Rahman Masmudur M; Rice Amanda; Moyer Richard W; Werden Steven J; McFadden Grant
Cowpox virus expresses a novel ankyrin repeat NF-kappaB inhibitor that controls inflammatory cell influx into virus-infected tissues and is critical for virus pathogenesis.
Journal of virology 2009;83(18):9223-36.
2009: Zhang Leiliang; Stanford Marianne; Liu Jia; Barrett Catherine; Jiang Lei; Barclay A Neil; McFadden Grant
Inhibition of macrophage activation by the myxoma virus M141 protein (vCD200).
Journal of virology 2009;83(18):9602-7.
2009: Barrett John W; Werden Steven J; Wang Fuan; McKillop William M; Jimenez June; Villeneuve Danielle; McFadden Grant; Dekaban Gregory A
Myxoma virus M130R is a novel virulence factor required for lethal myxomatosis in rabbits.
Virus research 2009;144(1-2):258-65.
2009: Mohamed Mohamed R; Rahman Masmudur M; Lanchbury Jerry S; Shattuck Donna; Neff Chris; Dufford Max; van Buuren Nick; Fagan Katharine; Barry Michele; Smith Scott; Damon Inger; McFadden Grant
Proteomic screening of variola virus reveals a unique NF-kappaB inhibitor that is highly conserved among pathogenic orthopoxviruses.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(22):9045-50.
2009: Wang Fuan; Barrett John W; Ma Yiyue; Dekaban Gregory A; McFadden Grant
Induction of alpha/beta interferon by myxoma virus is selectively abrogated when primary mouse embryo fibroblasts become immortalized.
Journal of virology 2009;83(11):5928-32.
2009: Liu Jia; Wennier Sonia; Reinhard Mary; Roy Edward; MacNeill Amy; McFadden Grant
Myxoma virus expressing interleukin-15 fails to cause lethal myxomatosis in European rabbits.
Journal of virology 2009;83(11):5933-8.
2009: Wang Fuan; Barrett John W; Shao Qing; Gao Xiujuan; Dekaban Gregory A; McFadden Grant
Myxoma virus selectively disrupts type I interferon signaling in primary human fibroblasts by blocking the activation of the Janus kinase Tyk2.
Virology 2009;387(1):136-46.
2009: Rahman Masmudur M; Jeng David; Singh Rajkumari; Coughlin Jake; Essani Karim; McFadden Grant
Interaction of human TNF and beta2-microglobulin with Tanapox virus-encoded TNF inhibitor, TPV-2L.
Virology 2009;386(2):462-8.
2009: Zhang Leiliang; Villa Nancy Y; McFadden Grant
Interplay between poxviruses and the cellular ubiquitin/ubiquitin-like pathways.
FEBS letters 2009;583(4):607-14.
2009: Bartee Eric; Mohamed Mohamed R; Lopez M Cecilia; Baker Henry V; McFadden Grant
The addition of tumor necrosis factor plus beta interferon induces a novel synergistic antiviral state against poxviruses in primary human fibroblasts.
Journal of virology 2009;83(2):498-511.
2009: Bartee Mee Y; Dai Erbin; Liu Liying; Munuswamy-Ramanujam Ganesh; Macaulay Colin; McIvor Dana; McFadden Grant; Lucas Alexandra R
10 M-T7: measuring chemokine-modulating activity.
Methods in enzymology 2009;460():209-28.
2008: Bartee Eric; Mohamed Mohamed R; McFadden Grant
Tumor necrosis factor and interferon: cytokines in harmony.
Current opinion in microbiology 2008;11(4):378-83.
2008: Wang Fuan; Gao Xiujuan; Barrett John W; Shao Qing; Bartee Eric; Mohamed Mohamed R; Rahman Masmudur; Werden Steve; Irvine Timothy; Cao Jingxin; Dekaban Gregory A; McFadden Grant
RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages.
PLoS pathogens 2008;4(7):e1000099.
2008: Wu Yushui; Lun Xueqing; Zhou Hongyuan; Wang Limei; Sun Beichen; Bell John C; Barrett John W; McFadden Grant; Biegel Jaclyn A; Senger Donna L; Forsyth Peter A
Oncolytic efficacy of recombinant vesicular stomatitis virus and myxoma virus in experimental models of rhabdoid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(4):1218-27.
2008: Stanford Marianne M; Breitbach Caroline J; Bell John C; McFadden Grant
Innate immunity, tumor microenvironment and oncolytic virus therapy: friends or foes?
Current opinion in molecular therapeutics 2008;10(1):32-7.
2008: Stanford Marianne M; Shaban Mae; Barrett John W; Werden Steven J; Gilbert Philippe-Alexandre; Bondy-Denomy Joe; Mackenzie Lisa; Graham Kevin C; Chambers Ann F; McFadden Grant
Myxoma virus oncolysis of primary and metastatic B16F10 mouse tumors in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(1):52-9.
2008: Nazarian Steven H; Rahman Masmudur M; Werden Steven J; Villeneuve Danielle; Meng Xiangzhi; Brunetti Craig; Valeriano Chalice; Wong Christina; Singh Rajkumari; Barrett John W; Xiang Yan; McFadden Grant
Yaba monkey tumor virus encodes a functional inhibitor of interleukin-18.
Journal of virology 2008;82(1):522-8.
2008: Werden Steven J; McFadden Grant
The role of cell signaling in poxvirus tropism: the case of the M-T5 host range protein of myxoma virus.
Biochimica et biophysica acta 2008;1784(1):228-37.
2008: Moussatché Nissin; Damaso Clarissa R; McFadden Grant
When good vaccines go wild: Feral Orthopoxvirus in developing countries and beyond.
Journal of infection in developing countries 2008;2(3):156-73.
2008: Li Xing; Schneider Heather; Peters Andrew; Macaulay Colin; King Elaine; Sun Yunming; Liu Liying; Dai Erbin; Davids Jennifer A; McFadden Grant; Lucas Alexandra
Heparin alters viral serpin, serp-1, anti-thrombolytic activity to anti-thrombotic activity.
The open biochemistry journal 2008;2():6-15.
2008: Werden Steven J; Rahman Masmudur M; McFadden Grant
Poxvirus host range genes.
Advances in virus research 2008;71():135-71.
2007: Barrett John W; Alston Lindsay R; Wang Fuan; Stanford Marianne M; Gilbert Philippe-Alexandre; Gao Xiujuan; Jimenez June; Villeneuve Danielle; Forsyth Peter; McFadden Grant
Identification of host range mutants of myxoma virus with altered oncolytic potential in human glioma cells.
Journal of neurovirology 2007;13(6):549-60.
2007: Jiang Jifu; Arp Jacqueline; Kubelik Dalibor; Zassoko Roman; Liu Weihua; Wise Yishai; Macaulay Colin; Garcia Bertha; McFadden Grant; Lucas Alexandra R; Wang Hao
Induction of indefinite cardiac allograft survival correlates with toll-like receptor 2 and 4 downregulation after serine protease inhibitor-1 (Serp-1) treatment.
Transplantation 2007;84(9):1158-67.
2007: Stanford Marianne M; Barrett John W; Gilbert Philippe-Alexandre; Bankert Richard; McFadden Grant
Myxoma virus expressing human interleukin-12 does not induce myxomatosis in European rabbits.
Journal of virology 2007;81(22):12704-8.
2007: Nazarian Steven H; Barrett John W; Stanford Marianne M; Johnston James B; Essani Karim; McFadden Grant
Tropism of Tanapox virus infection in primary human cells.
Virology 2007;368(1):32-40.
2007: Nazarian Steven H; Barrett John W; Frace A Michael; Olsen-Rasmussen Melissa; Khristova Marina; Shaban Mae; Neering Sarah; Li Yu; Damon Inger K; Esposito Joseph J; Essani Karim; McFadden Grant
Comparative genetic analysis of genomic DNA sequences of two human isolates of Tanapox virus.
Virus research 2007;129(1):11-25.
2007: Lun Xue Qing; Zhou Hongyuan; Alain Tommy; Sun Beichen; Wang Limei; Barrett John W; Stanford Marianne M; McFadden Grant; Bell John; Senger Donna L; Forsyth Peter A
Targeting human medulloblastoma: oncolytic virotherapy with myxoma virus is enhanced by rapamycin.
Cancer research 2007;67(18):8818-27.
2007: Stanford Marianne M; McFadden Grant
Myxoma virus and oncolytic virotherapy: a new biologic weapon in the war against cancer.
Expert opinion on biological therapy 2007;7(9):1415-25.
2007: Rahman Masmudur M; McFadden Grant
BAFfled by poxviruses?
Cell host & microbe 2007;1(3):159-60.
2007: Barrett John W; Shun Chang Chew; Wang Gen; Werden Steven J; Shao Zhuhong; Barrett Catherine; Gao Xiujuan; Belsito Tara A; Villenevue Danielle; McFadden Grant
Myxoma virus M063R is a host range gene essential for virus replication in rabbit cells.
Virology 2007;361(1):123-32.
2007: Stanford Marianne M; Werden Steven J; McFadden Grant
Myxoma virus in the European rabbit: interactions between the virus and its susceptible host.
Veterinary research 2007;38(2):299-318.
2007: Werden Steven J; Barrett John W; Wang Gen; Stanford Marianne M; McFadden Grant
M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A.
Journal of virology 2007;81(5):2340-8.
2007: Stanford Marianne M; McFadden Grant; Karupiah Gunasegaran; Chaudhri Geeta
Immunopathogenesis of poxvirus infections: forecasting the impending storm.
Immunology and cell biology 2007;85(2):93-102.
2007: Stanford Marianne M; Barrett John W; Nazarian Steven H; Werden Steven; McFadden Grant
Oncolytic virotherapy synergism with signaling inhibitors: Rapamycin increases myxoma virus tropism for human tumor cells.
Journal of virology 2007;81(3):1251-60.
2007: Barrett John W; Sypula Joanna; Wang Fuan; Alston Lindsay R; Shao Zhuhong; Gao Xiujuan; Irvine Timothy S; McFadden Grant
M135R is a novel cell surface virulence factor of myxoma virus.
Journal of virology 2007;81(1):106-14.
2006: Barrett John W; Sun Yunming; Nazarian Steven H; Belsito Tara A; Brunetti Craig R; McFadden Grant
Optimization of codon usage of poxvirus genes allows for improved transient expression in mammalian cells.
Virus genes 2006;33(1):15-26.
2006: Rahman Masmudur M; Barrett John W; Brouckaert Peter; McFadden Grant
Variation in ligand binding specificities of a novel class of poxvirus-encoded tumor necrosis factor-binding protein.
The Journal of biological chemistry 2006;281(32):22517-26.
2006: Bédard Eric L R; Jiang Jifu; Arp Jacqueline; Qian Hua; Wang Hao; Guan Haiyan; Liu Liying; Parry Neil; Kim Peter; Garcia Bertha; Li Xing; Macaulay Colin; McFadden Grant; Lucas Alexandra; Zhong Robert
Prevention of chronic renal allograft rejection by SERP-1 protein.
Transplantation 2006;81(6):908-14.
2006: Wang Gen; Barrett John W; Stanford Marianne; Werden Steven J; Johnston James B; Gao Xiujuan; Sun Mei; Cheng Jin Q; McFadden Grant
Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4640-5.
2006: Dai Erbin; Viswanathan Kasinath; Sun Yun Ming; Li Xing; Liu Li Ying; Togonu-Bickersteth Babajide; Richardson Jakob; Macaulay Colin; Nash Piers; Turner Peter; Nazarian Steven H; Moyer Richard; McFadden Grant; Lucas Alexandra R
Identification of myxomaviral serpin reactive site loop sequences that regulate innate immune responses.
The Journal of biological chemistry 2006;281(12):8041-50.
2006: Rahman Masmudur M; McFadden Grant
Modulation of tumor necrosis factor by microbial pathogens.
PLoS pathogens 2006;2(2):e4.
2006: Su Jin; Wang Gen; Barrett John W; Irvine Timothy S; Gao Xiujuan; McFadden Grant
Myxoma virus M11L blocks apoptosis through inhibition of conformational activation of Bax at the mitochondria.
Journal of virology 2006;80(3):1140-51.
2005: Johnston James B; Barrett John W; Nazarian Steven H; Goodwin Megan; Ricciuto Dan; Wang Gen; McFadden Grant
A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection.
Immunity 2005;23(6):587-98.
2005: Lun Xueqing; Yang Wenqing; Alain Tommy; Shi Zhong-Qiao; Muzik Huong; Barrett John W; McFadden Grant; Bell John; Hamilton Mark G; Senger Donna L; Forsyth Peter A
Myxoma virus is a novel oncolytic virus with significant antitumor activity against experimental human gliomas.
Cancer research 2005;65(21):9982-90.
2005: Johnston J B; Wang G; Barrett J W; Nazarian S H; Colwill K; Moran M; McFadden G
Myxoma virus M-T5 protects infected cells from the stress of cell cycle arrest through its interaction with host cell cullin-1.
Journal of virology 2005;79(16):10750-63.
2005: Gilbert Philippe-Alexandre; Comanita Lacrimioara; Barrett John; Peters Andrew; Szabat Marta; McFadden Grant; Dekaban Gregory A
Current Status for High Titre Poxvirus Stock Preparation in CEF Under Serum-Free Medium Conditions: Implication for Vaccine Development.
Cytotechnology 2005;48(1-3):79-88.
2005: Stanford Marianne M; McFadden Grant
The 'supervirus'? Lessons from IL-4-expressing poxviruses.
Trends in immunology 2005;26(6):339-45.
2005: Cameron C M; Barrett J W; Mann M; Lucas A; McFadden Grant
Myxoma virus M128L is expressed as a cell surface CD47-like virulence factor that contributes to the downregulation of macrophage activation in vivo.
Virology 2005;337(1):55-67.
2005: McFadden Grant
Poxvirus tropism.
Nature reviews. Microbiology 2005;3(3):201-13.
2005: Johnston J B; Nazarian Steven H; Natale Renato; McFadden Grant
Myxoma virus infection of primary human fibroblasts varies with cellular age and is regulated by host interferon responses.
Virology 2005;332(1):235-48.
2004: Wang Fuan; Ma Yiyue; Barrett John W; Gao Xiujuan; Loh Joy; Barton Erik; Virgin Herbert W; McFadden Grant
Disruption of Erk-dependent type I interferon induction breaks the myxoma virus species barrier.
Nature immunology 2004;5(12):1266-74.
2004: McFadden Grant
Smallpox: an ancient disease enters the modern era of virogenomics.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(42):14994-5.
2004: Lucas Alexandra; McFadden Grant
Secreted immunomodulatory viral proteins as novel biotherapeutics.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):4765-74.
2004: Johnston J B; McFadden Grant
Technical knockout: understanding poxvirus pathogenesis by selectively deleting viral immunomodulatory genes.
Cellular microbiology 2004;6(8):695-705.
2004: Wang Gen; Barrett John W; Nazarian Steven H; Everett Helen; Gao Xiujuan; Bleackley Chris; Colwill Karen; Moran Michael F; McFadden Grant
Myxoma virus M11L prevents apoptosis through constitutive interaction with Bak.
Journal of virology 2004;78(13):7097-111.
2004: Liu Liying; Dai Erbin; Miller Leslie; Seet Bruce; Lalani Alshad; Macauley Colin; Li Xing; Virgin Herbert W; Bunce Campbell; Turner Peter; Moyer Richard; McFadden Grant; Lucas Alexandra
Viral chemokine-binding proteins inhibit inflammatory responses and aortic allograft transplant vasculopathy in rat models.
Transplantation 2004;77(11):1652-60.
2004: Seet Bruce T; McFadden Grant
Interaction analysis of viral cytokine-binding proteins using surface plasmon resonance.
Methods in molecular biology (Clifton, N.J.) 2004;269():219-42.
2003: Seet Bruce T; McCaughan Catherine A; Handel Tracy M; Mercer Andrew; Brunetti Craig; McFadden Grant; Fleming Stephen B
Analysis of an orf virus chemokine-binding protein: Shifting ligand specificities among a family of poxvirus viroceptors.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15137-42.
2003: Brunetti Craig R; Amano Hiroko; Ueda Yoshiaki; Qin Jing; Miyamura Tatsuo; Suzuki Tetsuro; Li Xing; Barrett John W; McFadden Grant
Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus.
Journal of virology 2003;77(24):13335-47.
2003: Bédard Eric L R; Kim Peter; Jiang Jifu; Parry Neil; Liu Liying; Wang Hao; Garcia Bertha; Li Xing; McFadden Grant; Lucas Alexandra; Zhong Robert
Chemokine-binding viral protein M-T7 prevents chronic rejection in rat renal allografts.
Transplantation 2003;76(1):249-52.
2003: Johnston J B; McFadden Grant
Poxvirus immunomodulatory strategies: current perspectives.
Journal of virology 2003;77(11):6093-100.
2003: Johnston J B; Barrett John W; Chang Wen; Chung Che-Sheng; Zeng Wei; Masters Jennefer; Mann Melissa; Wang Fuan; Cao Jingxin; McFadden Grant
Role of the serine-threonine kinase PAK-1 in myxoma virus replication.
Journal of virology 2003;77(10):5877-88.
2003: Dai Erbin; Guan Haiyan; Liu Liying; Little Stephen; McFadden Grant; Vaziri Sepideh; Cao Henian; Ivanova Iordanka A; Bocksch Leila; Lucas Alexandra
Serp-1, a viral anti-inflammatory serpin, regulates cellular serine proteinase and serpin responses to vascular injury.
The Journal of biological chemistry 2003;278(20):18563-72.
2003: Brunetti Craig R; Paulose-Murphy Mini; Singh Rajkumari; Qin Jing; Barrett John W; Tardivel Aubry; Schneider Pascal; Essani Karim; McFadden Grant
A secreted high-affinity inhibitor of human TNF from Tanapox virus.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(8):4831-6.
2003: Seet Bruce T; Johnston J B; Brunetti Craig R; Barrett John W; Everett Helen; Cameron Cheryl; Sypula Joanna; Nazarian Steven H; Lucas Alexandra; McFadden Grant
Poxviruses and immune evasion.
Annual review of immunology 2003;21():377-423.
2002: Chang Chew Shun; McFadden Grant
Characterization of a pan-species reactive monoclonal antibody specific for a cell surface epitope which could serve as a marker for human monocytic and megakaryocytic differentiation.
Hybridoma and hybridomics 2002;21(6):445-56.
2002: Everett Helen; Barry Michele; Sun Xuejun; Lee Siow Fong; Frantz Christine; Berthiaume Luc G; McFadden Grant; Bleackley R Chris
The myxoma poxvirus protein, M11L, prevents apoptosis by direct interaction with the mitochondrial permeability transition pore.
The Journal of experimental medicine 2002;196(9):1127-39.
2002: Chang Chew Shun; McFadden Grant
Characterization of a monoclonal antibody specific for a novel primate cell surface marker with distinct biochemical properties on human erythroleukemia and myeloid cell lines.
Hybridoma and hybridomics 2002;21(4):271-80.
2002: Everett Helen; McFadden Grant
Poxviruses and apoptosis: a time to die.
Current opinion in microbiology 2002;5(4):395-402.
2002: Seet Bruce T; McFadden Grant
Viral chemokine-binding proteins.
Journal of leukocyte biology 2002;72(1):24-34.
2002: Cao Jing Xin; Teoh Melissa L T; Moon Mijin; McFadden Grant; Evans David H
Leporipoxvirus Cu-Zn superoxide dismutase homologs inhibit cellular superoxide dismutase, but are not essential for virus replication or virulence.
Virology 2002;296(1):125-35.
2001: Everett H; McFadden G
Viruses and apoptosis: meddling with mitochondria.
Virology 2001;288(1):1-7.
2001: Seet B T; Barrett J; Robichaud J; Shilton B; Singh R; McFadden G
Glycosaminoglycan binding properties of the myxoma virus CC-chemokine inhibitor, M-T1.
The Journal of biological chemistry 2001;276(32):30504-13.
2001: Seet B T; Singh R; Paavola C; Lau E K; Handel T M; McFadden G
Molecular determinants for CC-chemokine recognition by a poxvirus CC-chemokine inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9008-13.
2001: Everett H; McFadden G
Viral proteins and the mitochondrial apoptotic checkpoint.
Cytokine & growth factor reviews 2001;12(2-3):181-8.
2001: Barrett J W; Cao J X; Hota-Mitchell S; McFadden G
Immunomodulatory proteins of myxoma virus.
Seminars in immunology 2001;13(1):73-84.
2000: Lucas A; Dai E; Liu L; Guan H; Nash P; McFadden G; Miller L
Transplant vasculopathy: viral anti-inflammatory serpin regulation of atherogenesis.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2000;19(11):1029-38.
2000: McFadden G; Murphy P M
Host-related immunomodulators encoded by poxviruses and herpesviruses.
Current opinion in microbiology 2000;3(4):371-8.
2000: Christov A; Dai E; Drangova M; Liu L; Abela G S; Nash P; McFadden G; Lucas A
Optical detection of triggered atherosclerotic plaque disruption by fluorescence emission analysis.
Photochemistry and photobiology 2000;72(2):242-52.
2000: Nash P; McFadden G; Whitty A
Application of linear free energy relationships to the serpin-proteinase inhibition mechanism.
FEBS letters 2000;475(1):1-6.
2000: Liu L; Lalani A; Dai E; Seet B; Macauley C; Singh R; Fan L; McFadden G; Lucas A
The viral anti-inflammatory chemokine-binding protein M-T7 reduces intimal hyperplasia after vascular injury.
The Journal of clinical investigation 2000;105(11):1613-21.
2000: Everett H; Barry M; Lee S F; Sun X; Graham K; Stone J; Bleackley R C; McFadden G
M11L: a novel mitochondria-localized protein of myxoma virus that blocks apoptosis of infected leukocytes.
The Journal of experimental medicine 2000;191(9):1487-98.
2000: Nash P; Barry M; Seet B T; Veugelers K; Hota S; Heger J; Hodgkinson C; Graham K; Jackson R J; McFadden G
Post-translational modification of the myxoma-virus anti-inflammatory serpin SERP-1 by a virally encoded sialyltransferase.
The Biochemical journal 2000;347(Pt 2):375-82.
2000: Miller L W; Dai E; Nash P; Liu L; Icton C; Klironomos D; Fan L; Nation P N; Zhong R; McFadden G; Lucas A
Inhibition of transplant vasculopathy in a rat aortic allograft model after infusion of anti-inflammatory viral serpin.
Circulation 2000;101(13):1598-605.
2000: Xu X; Nash P; McFadden G
Myxoma virus expresses a TNF receptor homolog with two distinct functions.
Virus genes 2000;21(1-2):97-109.
1999: Lalani A S; Masters J; Zeng W; Barrett J; Pannu R; Everett H; Arendt C W; McFadden G
Use of chemokine receptors by poxviruses.
Science (New York, N.Y.) 1999;286(5446):1968-71.
1999: Willer D O; McFadden G; Evans D H
The complete genome sequence of shope (rabbit) fibroma virus.
Virology 1999;264(2):319-43.
1999: Cameron C; Hota-Mitchell S; Chen L; Barrett J; Cao J X; Macaulay C; Willer D; Evans D; McFadden G
The complete DNA sequence of myxoma virus.
Virology 1999;264(2):298-318.
1999: Hnatiuk S; Barry M; Zeng W; Liu L; Lucas A; Percy D; McFadden G
Role of the C-terminal RDEL motif of the myxoma virus M-T4 protein in terms of apoptosis regulation and viral pathogenesis.
Virology 1999;263(2):290-306.
1999: Nash P; Barrett J; Cao J X; Hota-Mitchell S; Lalani A S; Everett H; Xu X M; Robichaud J; Hnatiuk S; Ainslie C; Seet B T; McFadden G
Immunomodulation by viruses: the myxoma virus story.
Immunological reviews 1999;168():103-20.
1999: Everett H; McFadden G
Apoptosis: an innate immune response to virus infection.
Trends in microbiology 1999;7(4):160-5.
1999: Lalani A S; Masters J; Graham K; Liu L; Lucas A; McFadden G
Role of the myxoma virus soluble CC-chemokine inhibitor glycoprotein, M-T1, during myxoma virus pathogenesis.
Virology 1999;256(2):233-45.
1999: Christov A; Dai E; Liu L; Miller L W; Nash P; Lalani A; McFadden G; Nation P N; Tulip J; Lucas A
Detection of transplant vasculopathy in a rat aortic allograft model by fluorescence spectroscopic optical analysis.
Lasers in surgery and medicine 1999;24(5):346-59.
1998: Lalani A S; Ness T L; Singh R; Harrison J K; Seet B T; Kelvin D J; McFadden G; Moyer R W
Functional comparisons among members of the poxvirus T1/35kDa family of soluble CC-chemokine inhibitor glycoproteins.
Virology 1998;250(1):173-84.
1998: Barry M; McFadden G
Apoptosis regulators from DNA viruses.
Current opinion in immunology 1998;10(4):422-30.
1998: Nash P; Whitty A; Handwerker J; Macen J; McFadden G
Inhibitory specificity of the anti-inflammatory myxoma virus serpin, SERP-1.
The Journal of biological chemistry 1998;273(33):20982-91.
1998: McFadden G; Lalani A; Everett H; Nash P; Xu X
Virus-encoded receptors for cytokines and chemokines.
Seminars in cell & developmental biology 1998;9(3):359-68.
1998: McFadden G
Even viruses can learn to cope with stress.
Science (New York, N.Y.) 1998;279(5347):40-1.
1997: Barry M; Hnatiuk S; Mossman K; Lee S F; Boshkov L; McFadden G
The myxoma virus M-T4 gene encodes a novel RDEL-containing protein that is retained within the endoplasmic reticulum and is important for the productive infection of lymphocytes.
Virology 1997;239(2):360-77.
1997: Lalani A S; McFadden G
Secreted poxvirus chemokine binding proteins.
Journal of leukocyte biology 1997;62(5):570-6.
1997: Lalani A S; Graham K; Mossman K; Rajarathnam K; Clark-Lewis I; Kelvin D; McFadden G
The purified myxoma virus gamma interferon receptor homolog M-T7 interacts with the heparin-binding domains of chemokines.
Journal of virology 1997;71(6):4356-63.
1997: Graham K A; Lalani A S; Macen J L; Ness T L; Barry M; Liu L Y; Lucas A; Clark-Lewis I; Moyer R W; McFadden G
The T1/35kDa family of poxvirus-secreted proteins bind chemokines and modulate leukocyte influx into virus-infected tissues.
Virology 1997;229(1):12-24.
1997: Schreiber M; Sedger L; McFadden G
Distinct domains of M-T2, the myxoma virus tumor necrosis factor (TNF) receptor homolog, mediate extracellular TNF binding and intracellular apoptosis inhibition.
Journal of virology 1997;71(3):2171-81.
1997: McFadden G; Schreiber M; Sedger L
Myxoma T2 protein as a model for poxvirus TNF receptor homologs.
Journal of neuroimmunology 1997;72(2):119-26.
1997: Barry M; McFadden G
Virus encoded cytokines and cytokine receptors.
Parasitology 1997;115 Suppl():S89-100.
1997: Nash P; Lucas A; McFadden G
SERP-1, a poxvirus-encoded serpin, is expressed as a secreted glycoprotein that inhibits the inflammatory response to myxoma virus infection.
Advances in experimental medicine and biology 1997;425():195-205.
1996: Sedger L; McFadden G
M-T2: a poxvirus TNF receptor homologue with dual activities.
Immunology and cell biology 1996;74(6):538-45.
1996: Lucas A; Liu L; Macen J; Nash P; Dai E; Stewart M; Graham K; Etches W; Boshkov L; Nation P N; Humen D; Hobman M L; McFadden G
Virus-encoded serine proteinase inhibitor SERP-1 inhibits atherosclerotic plaque development after balloon angioplasty.
Circulation 1996;94(11):2890-900.
1996: Schreiber M; McFadden G
Mutational analysis of the ligand-binding domain of M-T2 protein, the tumor necrosis factor receptor homologue of myxoma virus.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(10):4486-95.
1996: Ellison K S; Peng W; McFadden G
Mutations in active-site residues of the uracil-DNA glycosylase encoded by vaccinia virus are incompatible with virus viability.
Journal of virology 1996;70(11):7965-73.
1996: Macen J L; Garner R S; Musy P Y; Brooks M A; Turner P C; Moyer R W; McFadden G; Bleackley R C
Differential inhibition of the Fas- and granule-mediated cytolysis pathways by the orthopoxvirus cytokine response modifier A/SPI-2 and SPI-1 protein.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):9108-13.
1996: McFadden G; Graham K; Barry M
New strategies of immune modulation by DNA viruses.
Transplantation proceedings 1996;28(4):2085-8.
1996: Mossman K; Lee S F; Barry M; Boshkov L; McFadden G
Disruption of M-T5, a novel myxoma virus gene member of poxvirus host range superfamily, results in dramatic attenuation of myxomatosis in infected European rabbits.
Journal of virology 1996;70(7):4394-410.
1996: Schreiber M; Rajarathnam K; McFadden G
Myxoma virus T2 protein, a tumor necrosis factor (TNF) receptor homolog, is secreted as a monomer and dimer that each bind rabbit TNFalpha, but the dimer is a more potent TNF inhibitor.
The Journal of biological chemistry 1996;271(23):13333-41.
1996: Maksymowych W P; Nation N; Nash P; Macen J; Lucas A; McFadden G; Russell A S
Amelioration of antigen induced arthritis in rabbits treated with a secreted viral serine proteinase inhibitor.
The Journal of rheumatology 1996;23(5):878-82.
1996: Macen J L; Graham K A; Lee S F; Schreiber M; Boshkov L K; McFadden G
Expression of the myxoma virus tumor necrosis factor receptor homologue and M11L genes is required to prevent virus-induced apoptosis in infected rabbit T lymphocytes.
Virology 1996;218(1):232-7.
1996: Mossman K; Nation P; Macen J; Garbutt M; Lucas A; McFadden G
Myxoma virus M-T7, a secreted homolog of the interferon-gamma receptor, is a critical virulence factor for the development of myxomatosis in European rabbits.
Virology 1996;215(1):17-30.
1995: Barry M; Lee S F; Boshkov L; McFadden G
Myxoma virus induces extensive CD4 downregulation and dissociation of p56lck in infected rabbit CD4+ T lymphocytes.
Journal of virology 1995;69(9):5243-51.
1995: McFadden G; Graham K; Ellison K; Barry M; Macen J; Schreiber M; Mossman K; Nash P; Lalani A; Everett H
Interruption of cytokine networks by poxviruses: lessons from myxoma virus.
Journal of leukocyte biology 1995;57(5):731-8.
1995: McFadden G
Getting to know you: viruses meet CD40 ligand.
Nature medicine 1995;1(5):408-9.
1995: Mossman K; Upton C; Buller R M; McFadden G
Species specificity of ectromelia virus and vaccinia virus interferon-gamma binding proteins.
Virology 1995;208(2):762-9.
1995: Mossman K; Upton C; McFadden G
The myxoma virus-soluble interferon-gamma receptor homolog, M-T7, inhibits interferon-gamma in a species-specific manner.
The Journal of biological chemistry 1995;270(7):3031-8.
1995: Mossman K; Ostergaard H; Upton C; McFadden G
Myxoma virus and Shope fibroma virus encode dual-specificity tyrosine/serine phosphatases which are essential for virus viability.
Virology 1995;206(1):572-82.
1994: Schreiber M; McFadden G
The myxoma virus TNF-receptor homologue (T2) inhibits tumor necrosis factor-alpha in a species-specific fashion.
Virology 1994;204(2):692-705.
1994: Upton C; Schiff L; Rice S A; Dowdeswell T; Yang X; McFadden G
A poxvirus protein with a RING finger motif binds zinc and localizes in virus factories.
Journal of virology 1994;68(7):4186-95.
1994: McFadden G; Kane K
How DNA viruses perturb functional MHC expression to alter immune recognition.
Advances in cancer research 1994;63():117-209.
1993: Macen J L; Upton C; Nation N; McFadden G
SERP1, a serine proteinase inhibitor encoded by myxoma virus, is a secreted glycoprotein that interferes with inflammation.
Virology 1993;195(2):348-63.
1993: Stuart D T; Upton C; Higman M A; Niles E G; McFadden G
A poxvirus-encoded uracil DNA glycosylase is essential for virus viability.
Journal of virology 1993;67(5):2503-12.
1993: Upton C; Stuart D T; McFadden G
Identification of a poxvirus gene encoding a uracil DNA glycosylase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4518-22.
1993: Opgenorth A; Nation N; Graham K; McFadden G
Transforming growth factor alpha, Shope fibroma growth factor, and vaccinia growth factor can replace myxoma growth factor in the induction of myxomatosis in rabbits.
Virology 1993;192(2):701-9.
1992: Upton C; Mossman K; McFadden G
Encoding of a homolog of the IFN-gamma receptor by myxoma virus.
Science (New York, N.Y.) 1992;258(5086):1369-72.
1992: Graham K A; Opgenorth A; Upton C; McFadden G
Myxoma virus M11L ORF encodes a protein for which cell surface localization is critical in manifestation of viral virulence.
Virology 1992;191(1):112-24.
1992: Opgenorth A; Graham K; Nation N; Strayer D; McFadden G
Deletion analysis of two tandemly arranged virulence genes in myxoma virus, M11L and myxoma growth factor.
Journal of virology 1992;66(8):4720-31.
1992: Stuart D; Ellison K; Graham K; McFadden G
In vitro resolution of poxvirus replicative intermediates into linear minichromosomes with hairpin termini by a virally induced Holliday junction endonuclease.
Journal of virology 1992;66(3):1551-63.
1992: Boshkov L K; Macen J L; McFadden G
Virus-induced loss of class I MHC antigens from the surface of cells infected with myxoma virus and malignant rabbit fibroma virus.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(3):881-7.
1992: Opgenorth A; Strayer D; Upton C; McFadden G
Deletion of the growth factor gene related to EGF and TGF alpha reduces virulence of malignant rabbit fibroma virus.
Virology 1992;186(1):175-91.
1991: Upton C; Macen J L; Schreiber M; McFadden G
Myxoma virus expresses a secreted protein with homology to the tumor necrosis factor receptor gene family that contributes to viral virulence.
Virology 1991;184(1):370-82.
1991: Upton C; Stuart D; McFadden G
Identification and DNA sequence of the large subunit of the capping enzyme from Shope fibroma virus.
Virology 1991;183(2):773-7.
1991: Stuart D; Graham K; Schreiber M; Macaulay C; McFadden G
The target DNA sequence for resolution of poxvirus replicative intermediates is an active late promoter.
Journal of virology 1991;65(1):61-70.
1990: Upton C; Macen J L; Wishart D S; McFadden G
Myxoma virus and malignant rabbit fibroma virus encode a serpin-like protein important for virus virulence.
Virology 1990;179(2):618-31.
1990: Upton C; Opgenorth A; Traktman P; McFadden G
Identification and DNA sequence of the Shope fibroma virus DNA topoisomerase gene.
Virology 1990;176(2):439-47.
1990: DeLange A M; McFadden G
The role of telomeres in poxvirus DNA replication.
Current topics in microbiology and immunology 1990;163():71-92.
1989: Macaulay C; McFadden G
Tumorigenic poxviruses: characterization of an early promoter from Shope fibroma virus.
Virology 1989;172(1):237-46.
1988: Upton C; Macen J L; Maranchuk R A; DeLange A M; McFadden G
Tumorigenic poxviruses: fine analysis of the recombination junctions in malignant rabbit fibroma virus, a recombinant between Shope fibroma virus and myxoma virus.
Virology 1988;166(1):229-39.
1988: Dickie P; Morgan A R; McFadden G
Conformational isomerization of the Holliday junction associated with a cruciform during branch migration in supercoiled plasmid DNA.
Journal of molecular biology 1988;201(1):19-30.
1988: Henning W D; Upton C; McFadden G; Majumdar R; Bridger W A
Cloning and sequencing of the cytoplasmic precursor to the alpha subunit of rat liver mitochondrial succinyl-CoA synthetase.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(5):1432-6.
1987: Dickie P; McFadden G; Morgan A R
The site-specific cleavage of synthetic Holliday junction analogs and related branched DNA structures by bacteriophage T7 endonuclease I.
The Journal of biological chemistry 1987;262(30):14826-36.
1987: Upton C; DeLange A M; McFadden G
Tumorigenic poxviruses: genomic organization and DNA sequence of the telomeric region of the Shope fibroma virus genome.
Virology 1987;160(1):20-30.
1987: Dickie P; Morgan A R; McFadden G
Cruciform extrusion in plasmids bearing the replicative intermediate configuration of a poxvirus telomere.
Journal of molecular biology 1987;196(3):541-58.
1987: DeLange A M; McFadden G
Efficient resolution of replicated poxvirus telomeres to native hairpin structures requires two inverted symmetrical copies of a core target DNA sequence.
Journal of virology 1987;61(6):1957-63.
1987: Upton C; Macen J L; McFadden G
Mapping and sequencing of a gene from myxoma virus that is related to those encoding epidermal growth factor and transforming growth factor alpha.
Journal of virology 1987;61(4):1271-5.
1986: DeLange A M; Reddy M; Scraba D; Upton C; McFadden G
Replication and resolution of cloned poxvirus telomeres in vivo generates linear minichromosomes with intact viral hairpin termini.
Journal of virology 1986;59(2):249-59.
1986: DeLange A M; McFadden G
Sequence-nonspecific replication of transfected plasmid DNA in poxvirus-infected cells.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(3):614-8.
1984: Delange A M; Macaulay C; Block W; Mueller T; McFadden G
Tumorigenic poxviruses: construction of the composite physical map of the Shope fibroma virus genome.
Journal of virology 1984;50(2):408-16.
1984: DeLange A M; Futcher B; Morgan R; McFadden G
Cloning of the vaccinia virus telomere in a yeast plasmid vector.
Gene 1984;27(1):13-21.
1983: Wills A; Delange A M; Gregson C; Macaulay C; McFadden G
Physical characterization and molecular cloning of the Shope fibroma virus DNA genome.
Virology 1983;130(2):403-14.

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