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Lesley McFarlane

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Arun Nair; Karine Clearie; Daniel Menzies; Karen Meldrum; Lesley C McFarlane; Brian J Lipworth
A novel breath-actuated integrated vortex spacer device increases relative lung bioavailability of fluticasone/salmeterol in combination.
Arun Nair; Daniel Menzies; Pippa Hopkinson; Lesley C McFarlane; Brian J Lipworth
In vivo comparison of the relative systemic bioavailability of fluticasone propionate from three anti-static spacers and a metered dose inhaler.
Arun Nair; Daniel Menzies; Martyn Barnes; Patricia Burns; Lesley C McFarlane; Brian J Lipworth
Respirable dose delivery of fluticasone propionate from a small valved holding chamber, a compact breath actuated integrated vortex device and a metered dose inhaler.

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All Publications

2009: Arun Nair; Karine Clearie; Daniel Menzies; Karen Meldrum; Lesley C McFarlane; Brian J Lipworth
A novel breath-actuated integrated vortex spacer device increases relative lung bioavailability of fluticasone/salmeterol in combination.
Pulmonary pharmacology & therapeutics 2009;22(4):305-10.
2009: Arun Nair; Daniel Menzies; Pippa Hopkinson; Lesley C McFarlane; Brian J Lipworth
In vivo comparison of the relative systemic bioavailability of fluticasone propionate from three anti-static spacers and a metered dose inhaler.
British journal of clinical pharmacology 2009;67(2):191-8.
2008: Arun Nair; Daniel Menzies; Martyn Barnes; Patricia Burns; Lesley C McFarlane; Brian J Lipworth
Respirable dose delivery of fluticasone propionate from a small valved holding chamber, a compact breath actuated integrated vortex device and a metered dose inhaler.
British journal of clinical pharmacology 2008;66(1):20-6.
2007: Zia R Tayab; Tom C Fardon; Daniel K C Lee; Kay Haggart; Lesley C McFarlane; Brian J Lipworth; Günther Hochhaus
Pharmacokinetic/pharmacodynamic evaluation of urinary cortisol suppression after inhalation of fluticasone propionate and mometasone furoate.
British journal of clinical pharmacology 2007;64(5):698-705.
2007: Daniel Menzies; A Nair; P Hopkinson; Lesley C McFarlane; Brian J Lipworth
Differential anti-inflammatory effects of large and small particle size inhaled corticosteroids in asthma.
Allergy 2007;62(6):661-7.
2006: Daniel Menzies; Arun Nair; Peter A Williamson; Stuart Schembri; Mudher Z H Al-Khairalla; Martyn Barnes; Tom C Fardon; Lesley C McFarlane; Gareth J Magee; Brian J Lipworth
Respiratory symptoms, pulmonary function, and markers of inflammation among bar workers before and after a legislative ban on smoking in public places.
JAMA : the journal of the American Medical Association 2006;296(14):1742-8.
2005: Daniel K C Lee; Tom C Fardon; Caroline E Bates; Kay Haggart; Lesley C McFarlane; Brian J Lipworth
Airway and systemic effects of hydrofluoroalkane formulations of high-dose ciclesonide and fluticasone in moderate persistent asthma.
Chest 2005;127(3):851-60.
2004: Tom C Fardon; Daniel K C Lee; Kay Haggart; Lesley C McFarlane; Brian J Lipworth
Adrenal suppression with dry powder formulations of fluticasone propionate and mometasone furoate.
American journal of respiratory and critical care medicine 2004;170(9):960-6.
2004: Daniel K C Lee; Caroline E Bates; Graeme P Currie; Louise M Cowan; Lesley C McFarlane; Brian J Lipworth
Effects of high-dose inhaled fluticasone propionate on the hypothalamic-pituitary-adrenal axis in asthmatic patients with severely impaired lung function.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2004;93(3):253-8.
2003: Graeme P Currie; N J Syme-Grant; Lesley C McFarlane; Francis A Carey; Brian J Lipworth
Effects of low dose fluticasone/salmeterol combination on surrogate inflammatory markers in moderate persistent asthma.
Allergy 2003;58(7):602-7.
2003: Daniel K C Lee; Fiona M Robb; Erika J Sims; Graeme P Currie; Lesley C McFarlane; Brian J Lipworth
Systemic bioactivity of intranasal triamcinolone and mometasone in perennial allergic rhinitis.
British journal of clinical pharmacology 2003;55(3):310-3.
2002: Stephen J Fowler; Linda C Orr; Erika J Sims; Andrew M Wilson; Graeme P Currie; Lesley C McFarlane; Brian J Lipworth
Therapeutic ratio of hydrofluoroalkane and chlorofluorocarbon formulations of fluticasone propionate.
Chest 2002;122(2):618-23.
2000: AF Lee; Lesley C McFarlane; Allan D Struthers
Ovarian hormones in man: their effects on resting vascular tone, angiotensin converting enzyme activity and angiotensin II-induced vasoconstriction.
British journal of clinical pharmacology 2000;50(1):73-6.
1999: I Aziz; Lesley C McFarlane; Brian J Lipworth
Comparative trough effects of formoterol and salmeterol on lymphocyte beta2-adrenoceptor--regulation and bronchodilatation.
European journal of clinical pharmacology 1999;55(6):431-6.
1998: Andrew M Wilson; Erika J Sims; Lesley C McFarlane; Brian J Lipworth
Effects of intranasal corticosteroids on adrenal, bone, and blood markers of systemic activity in allergic rhinitis.
The Journal of allergy and clinical immunology 1998;102(4 Pt 1):598-604.
1998: Andrew M Wilson; Lesley C McFarlane; Brian J Lipworth
Systemic bioactivity profiles of oral prednisolone and nebulized budesonide in adult asthmatics.
Chest 1998;114(4):1022-7.
1998: I Aziz; Lesley C McFarlane; Brian J Lipworth
Concomitant inhaled corticosteroid resensitises cardiac beta2-adrenoceptors in the presence of long-acting beta2-agonist therapy.
European journal of clinical pharmacology 1998;54(5):377-81.
1998: Andrew M Wilson; Lesley C McFarlane; Brian J Lipworth
Effects of repeated once daily dosing of three intranasal corticosteroids on basal and dynamic measures of hypothalamic-pituitary-adrenal-axis activity.
The Journal of allergy and clinical immunology 1998;101(4 Pt 1):470-4.
1998: I Aziz; Ian P Hall; Lesley C McFarlane; Brian J Lipworth
Beta2-adrenoceptor regulation and bronchodilator sensitivity after regular treatment with formoterol in subjects with stable asthma.
The Journal of allergy and clinical immunology 1998;101(3):337-41.
1998: Andrew M Wilson; Lesley C McFarlane; Brian J Lipworth
Effects of low and high doses of inhaled flunisolide and triamcinolone acetonide on basal and dynamic measures of adrenocortical activity in healthy volunteers.
The Journal of clinical endocrinology and metabolism 1998;83(3):922-5.
1998: KS Tan; Lesley C McFarlane; Brian J Lipworth
Beta2-adrenoceptor regulation and function in female asthmatic patients receiving the oral combined contraceptive pill.
Chest 1998;113(2):278-82.
1998: Andrew M Wilson; DJ Clark; M M Devlin; Lesley C McFarlane; Brian J Lipworth
Adrenocortical activity with repeated administration of one-daily inhaled fluticasone propionate and budesonide in asthmatic adults.
European journal of clinical pharmacology 1998;53(5):317-20.
1998: KS Tan; Lesley C McFarlane; Brian J Lipworth
Concomitant administration of low-dose prednisolone protects against in vivo beta2-adrenoceptor subsensitivity induced by regular formoterol.
Chest 1998;113(1):34-41.
1997: KS Tan; Lesley C McFarlane; Brian J Lipworth
Effects of oral and inhaled corticosteroid on lymphocyte beta2-adrenoceptor function in asthmatic patients.
British journal of clinical pharmacology 1997;44(6):565-8.
1997: Andrew M Wilson; Lesley C McFarlane; Brian J Lipworth
Dose-response effect for adrenal suppression with repeated twice daily inhaled fluticasone propionate and triamcinolone acetonide in adult asthmatics.
American journal of respiratory and critical care medicine 1997;156(4 Pt 1):1274-7.
1997: Brian J Lipworth; DJ Clark; Lesley C McFarlane
Adrenocortical activity with repeated twice daily dosing of fluticasone propionate and budesonide given via a large volume spacer to asthmatic school children.
Thorax 1997;52(8):686-9.
1997: KS Tan; Lesley C McFarlane; Brian J Lipworth
Loss of normal cyclical beta 2 adrenoceptor regulation and increased premenstrual responsiveness to adenosine monophosphate in stable female asthmatic patients.
Thorax 1997;52(7):608-11.
1997: KS Tan; Lesley C McFarlane; Brian J Lipworth
Paradoxical down-regulation and desensitization of beta2-adrenoceptors by exogenous progesterone in female asthmatics.
Chest 1997;111(4):847-51.
1997: KS Tan; Lesley C McFarlane; Brian J Lipworth
Modulation of airway reactivity and peak flow variability in asthmatics receiving the oral contraceptive pill.
American journal of respiratory and critical care medicine 1997;155(4):1273-7.
1997: Andrew M Wilson; DJ Clark; Lesley C McFarlane; Brian J Lipworth
Adrenal suppression with high doses of inhaled fluticasone propionate and triamcinolone acetonide in healthy volunteers.
European journal of clinical pharmacology 1997;53(1):33-7.
1997: KS Tan; Lesley C McFarlane; Brian J Lipworth
Effect of exogenous female sex-steroid hormones on beta 2-adrenoceptors in healthy males.
European journal of clinical pharmacology 1997;52(4):281-3.
1996: KS Tan; Lesley C McFarlane; Wendy J R Coutie; Brian J Lipworth
Effects of exogenous female sex-steroid hormones on lymphocyte beta 2-adrenoceptors in normal females.
British journal of clinical pharmacology 1996;41(5):414-6.
1996: KS Tan; A Grove; R I Cargill; Lesley C McFarlane; Brian J Lipworth
Effects of inhaled fluticasone propionate and oral prednisolone on lymphocyte beta 2-adrenoceptor function in asthmatic patients.
Chest 1996;109(2):343-7.
1996: R I Cargill; Lesley C McFarlane; Wendy J R Coutie; Brian J Lipworth
Acute neurohormonal responses to hypoxaemia in man.
European journal of applied physiology and occupational physiology 1996;72(3):256-60.
1996: A Grove; Lesley C McFarlane; C M Jackson; Brian J Lipworth
Effects of short-term exposure to high-dose inhaled corticosteroids on novel markers of bone metabolism.
European journal of clinical pharmacology 1996;50(4):275-7.
1995: A Grove; Lesley C McFarlane; Brian J Lipworth
Expression of the beta 2 adrenoceptor partial agonist/antagonist activity of salbutamol in states of low and high adrenergic tone.
Thorax 1995;50(2):134-8.
1994: A Grove; C Allam; Lesley C McFarlane; G McPhate; C M Jackson; Brian J Lipworth
A comparison of the systemic bioactivity of inhaled budesonide and fluticasone propionate in normal subjects.
British journal of clinical pharmacology 1994;38(6):527-32.
1994: N M Wheeldon; DG McDevitt; Lesley C McFarlane; Brian J Lipworth
Beta-adrenoceptor subtypes mediating the metabolic effects of BRL 35135 in man.
Clinical science (London, England : 1979) 1994;86(3):331-7.
1994: D M Newnham; N M Wheeldon; Lesley C McFarlane; G A Clark; DG McDevitt; Brian J Lipworth
Extrapulmonary beta 2-responses to intravenous salbutamol during the menstrual cycle.
European journal of clinical pharmacology 1994;46(6):511-5.
1993: D M Newnham; Wendy J R Coutie; Lesley C McFarlane; Brian J Lipworth
Comparison of parameters of in vitro lymphocyte beta 2-adrenoceptor function in normal and asthmatic subjects.
European journal of clinical pharmacology 1993;45(6):535-8.
1989: Brian J Lipworth; Lesley C McFarlane; Wendy J R Coutie; DG McDevitt
Evaluation of the metabolic responses to inhaled salbutamol in the measurement of beta 2-adrenoceptor blockade.
European journal of clinical pharmacology 1989;37(3):297-300.
1988: J McMurray; Wendy J R Coutie; Lesley C McFarlane; Allan D Struthers
Atrial natriuretic factor inhibits ACTH stimulated aldosterone, but not cortisol, secretion in man.
European journal of clinical pharmacology 1988;35(4):409-12.