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Dorian McGavern

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Bernd H Zinselmeyer; Debasis Nayak; Catarina Sacristán; Michael Cammer; Xiaoxiao Cheng; Simon J Davis; Michael L Dustin; Jasmin Herz; Sara Heydari; Dorian B McGavern
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis.
Jasmin Herz; Bernd H Zinselmeyer; Dorian B McGavern
Two-photon imaging of microbial immunity in living tissues.
lucile garidou; Selamawit Gossa; Sara Heydari; Dorian B McGavern
Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection.

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All Publications

2013: Bernd H Zinselmeyer; Debasis Nayak; Catarina Sacristán; Michael Cammer; Xiaoxiao Cheng; Simon J Davis; Michael L Dustin; Jasmin Herz; Sara Heydari; Dorian B McGavern
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis.
The Journal of experimental medicine 2013;210(4):757-74.
2012: Jasmin Herz; Bernd H Zinselmeyer; Dorian B McGavern
Two-photon imaging of microbial immunity in living tissues.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2012;18(4):730-41.
2012: lucile garidou; Selamawit Gossa; Sara Heydari; Dorian B McGavern
Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection.
Journal of virology 2012;86(13):7060-71.
2012: Michael B A Oldstone; Justin T Cruite; Kurt H Edelmann; Dorian B McGavern; Megan J Welch
Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes.
PLoS pathogens 2012;8(11):e1003044.
2011: Laura M Fahey; Elizabeth B Wilson; Heidi Elsaesser; Chris D Fistonich; Dorian B McGavern; David G Brooks
Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells.
The Journal of experimental medicine 2011;208(5):987-99.
2011: Dorian B McGavern; Silvia S Kang
Illuminating viral infections in the nervous system.
Nature reviews. Immunology 2011;11(5):318-29.
2011: Silvia S Kang; Jasmin Herz; Jiyun V Kim; Debasis Nayak; Phillip Stewart-Hutchinson; Michael L Dustin; Dorian B McGavern
Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection.
The Journal of experimental medicine 2011;208(4):747-59.
2010: Silvia S Kang; Dorian B McGavern
Microbial induction of vascular pathology in the CNS.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2010;5(3):370-86.
2010: Dorian B McGavern
A little 'help' from IL-21 during persistent viral infection.
Journal of molecular cell biology 2010;2(1):8-10.
2009: Phi Truong; Sara Heydari; lucile garidou; Dorian B McGavern
Persistent viral infection elevates central nervous system MHC class I through chronic production of interferons.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3895-905.
2009: lucile garidou; Sara Heydari; Phi Truong; David G Brooks; Dorian B McGavern
Therapeutic memory T cells require costimulation for effective clearance of a persistent viral infection.
Journal of virology 2009;83(17):8905-15.
2009: Sebastien F Emonet; lucile garidou; Dorian B McGavern; Juan C de la Torre
Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3473-8.
2009: David Marsolais; Bumsuk Hahm; Kevin B Walsh; Kurt H Edelmann; Dorian B McGavern; Yasuko Hatta; Yoshihiro Kawaoka; Hugh Rosen; Michael B A Oldstone
A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(5):1560-5.
2009: Jiyun V Kim; Silvia S Kang; Michael L Dustin; Dorian B McGavern
Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis.
Nature 2009;457(7226):191-5.
2009: Silvia S Kang; Dorian B McGavern
Inflammation on the mind: visualizing immunity in the central nervous system.
Current topics in microbiology and immunology 2009;334():227-63.
2008: Matthew J Trifilo; Manuel Sanchez-Alavez; Laura Solforosi; Joie Trifilo; Stefan Kunz; Dorian B McGavern; Michael B A Oldstone
Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway.
Journal of virology 2008;82(20):9890-9.
2008: Phi Truong; Dorian B McGavern
A novel virus carrier state to evaluate immunotherapeutic regimens: regulatory T cells modulate the pathogenicity of antiviral memory cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1161-9.
2008: David G Brooks; Andrew M Lee; Heidi Elsaesser; Dorian B McGavern; Michael B A Oldstone
IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection.
The Journal of experimental medicine 2008;205(3):533-41.
2008: Silvia S Kang; Dorian B McGavern
Lymphocytic choriomeningitis infection of the central nervous system.
Frontiers in bioscience : a journal and virtual library 2008;13():4529-43.
2007: Henning Lauterbach; Phi Truong; Dorian B McGavern
Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification.
Virology journal 2007;4():53.
2006: David G Brooks; Matthew J Trifilo; Kurt H Edelmann; Luc Teyton; Dorian B McGavern; Michael B A Oldstone
Interleukin-10 determines viral clearance or persistence in vivo.
Nature medicine 2006;12(11):1301-9.
2006: Stefan Kunz; Jillian M Rojek; Amanda J Roberts; Dorian B McGavern; Michael B A Oldstone; Juan Carlos de la Torre
Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus.
Journal of virology 2006;80(18):9082-92.
2006: Henning Lauterbach; Elina I Zuniga; Phi Truong; Michael B A Oldstone; Dorian B McGavern
Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection.
The Journal of experimental medicine 2006;203(8):1963-75.
2006: David G Brooks; Dorian B McGavern; Michael B A Oldstone
Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection.
The Journal of clinical investigation 2006;116(6):1675-85.
2006: Antoinette Tishon; Hanna Lewicki; Abegail Andaya; Dorian B McGavern; Lee Martin; Michael B A Oldstone
CD4 T cell control primary measles virus infection of the CNS: regulation is dependent on combined activity with either CD8 T cells or with B cells: CD4, CD8 or B cells alone are ineffective.
Virology 2006;347(1):234-45.
2006: Dorian B McGavern
Immunotherapeutic relief from persistent infections and amyloid disorders.
Neurology 2006;66(2 Suppl 1):S59-64.
2005: David G Brooks; Luc Teyton; Michael B A Oldstone; Dorian B McGavern
Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection.
Journal of virology 2005;79(16):10514-27.
2005: Mikhail Popkov; Nina Jendreyko; Dorian B McGavern; Christoph Rader; Carlos F Barbas
Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody.
Cancer research 2005;65(3):972-81.
2005: Dorian B McGavern
The role of bystander T cells in CNS pathology and pathogen clearance.
Critical reviews in immunology 2005;25(4):289-303.
2004: Elina I Zuniga; Dorian B McGavern; Jose L Pruneda-Paz; Chao Teng; Michael B A Oldstone
Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection.
Nature immunology 2004;5(12):1227-34.
2004: Urs Christen; Kurt H Edelmann; Dorian B McGavern; Tom Wolfe; Bryan Coon; Meghann K Teague; Stephen D Miller; Michael B A Oldstone; Matthias G von Herrath
A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes.
The Journal of clinical investigation 2004;114(9):1290-8.
2004: Dorian B McGavern; Phi Truong
Rebuilding an immune-mediated central nervous system disease: weighing the pathogenicity of antigen-specific versus bystander T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):4779-90.
2004: Dirk Homann; Dorian B McGavern; Michael B A Oldstone
Visualizing the viral burden: phenotypic and functional alterations of T cells and APCs during persistent infection.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6239-50.
2004: Laura Solforosi; José R Criado; Dorian B McGavern; Sebastian A Wirz; Manuel Sánchez-Alavez; Shuei Sugama; Lorraine A DeGiorgio; Bruce T Volpe; Erika Wiseman; Gil Abalos; Eliezer Masliah; Donald Gilden; Michael B A Oldstone; Bruno Conti; R Anthony Williamson
Cross-linking cellular prion protein triggers neuronal apoptosis in vivo.
Science (New York, N.Y.) 2004;303(5663):1514-6.
2004: Noemí Sevilla; Dorian B McGavern; Chao Teng; Stefan Kunz; Michael B A Oldstone
Viral targeting of hematopoietic progenitors and inhibition of DC maturation as a dual strategy for immune subversion.
The Journal of clinical investigation 2004;113(5):737-45.
2003: Urs Christen; Dorian B McGavern; Andrew D Luster; Matthias G von Herrath; Michael B A Oldstone
Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6838-45.
2003: Nina Jendreyko; Mikhail Popkov; Roger R Beerli; Junho Chung; Dorian B McGavern; Christoph Rader; Carlos F Barbas
Intradiabodies, bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors.
The Journal of biological chemistry 2003;278(48):47812-9.
2003: Thomas Stratmann; Natalia Martin-Orozco; Valérie Mallet-Designe; Laurent Poirot; Dorian B McGavern; Grigoriy Losyev; Cathleen Dobbs; Michael B A Oldstone; Kenji Yoshida; Hitoshi Kikutani; Diane Mathis; Christophe Benoist; Kathryn Haskins; Luc Teyton
Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.
The Journal of clinical investigation 2003;112(6):902-14.
2003: Laurie J Zoecklein; Kevin Pavelko; Jeff Gamez; Louisa M Papke; Dorian B McGavern; Daren R Ure; M Kariuki Njenga; Aaron J Johnson; Shunya Nakane; Moses Rodriguez
Direct comparison of demyelinating disease induced by the Daniel's strain and BeAn strain of Theiler's murine encephalomyelitis virus.
Brain pathology (Zurich, Switzerland) 2003;13(3):291-308.
2003: Noemí Sevilla; Stefan Kunz; Dorian B McGavern; Michael B A Oldstone
Infection of dendritic cells by lymphocytic choriomeningitis virus.
Current topics in microbiology and immunology 2003;276():125-44.
2002: Dorian B McGavern; Dirk Homann; Michael B A Oldstone
T cells in the central nervous system: the delicate balance between viral clearance and disease.
The Journal of infectious diseases 2002;186 Suppl 2():S145-51.
2002: Dorian B McGavern; Urs Christen; Michael B A Oldstone
Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivo.
Nature immunology 2002;3(10):918-25.
2002: Claudia F Lucchinetti; Raul N Mandler; Dorian B McGavern; Wolfgang Bruck; Gerald Gleich; Richard M Ransohoff; Corinna Trebst; Brian G Weinshenker; Dean M Wingerchuk; Joseph E Parisi; Hans Lassmann
A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica.
Brain : a journal of neurology 2002;125(Pt 7):1450-61.
2002: Paul D Murray; Dorian B McGavern; Larry R Pease; Moses Rodriguez
Cellular sources and targets of IFN-gamma-mediated protection against viral demyelination and neurological deficits.
European journal of immunology 2002;32(3):606-15.
2001: Stefan Kunz; Noemí Sevilla; Dorian B McGavern; Kevin P Campbell; Michael B A Oldstone
Molecular analysis of the interaction of LCMV with its cellular receptor [alpha]-dystroglycan.
The Journal of cell biology 2001;155(2):301-10.
2001: Paul D Murray; Dorian B McGavern; S Sathornsumetee; Moses Rodriguez
Spontaneous remyelination following extensive demyelination is associated with improved neurological function in a viral model of multiple sclerosis.
Brain : a journal of neurology 2001;124(Pt 7):1403-16.
2000: S Sathornsumetee; Dorian B McGavern; Daren R Ure; Moses Rodriguez
Quantitative ultrastructural analysis of a single spinal cord demyelinated lesion predicts total lesion load, axonal loss, and neurological dysfunction in a murine model of multiple sclerosis.
The American journal of pathology 2000;157(4):1365-76.
2000: Dorian B McGavern; Laurie J Zoecklein; S Sathornsumetee; Moses Rodriguez
Assessment of hindlimb gait as a powerful indicator of axonal loss in a murine model of progressive CNS demyelination.
Brain research 2000;877(2):396-400.
2000: Moses Rodriguez; Raymond P Roos; Dorian B McGavern; Laurie J Zoecklein; Kevin Pavelko; H Sang; Xiaoqi Lin
The CD4-mediated immune response is critical in determining the outcome of infection using Theiler's viruses with VP1 capsid protein point mutations.
Virology 2000;275(1):9-19.
2000: Kevin Pavelko; Kristen Drescher; Dorian B McGavern; Chella S David; Moses Rodriguez
HLA-DQ polymorphism influences progression of demyelination and neurologic deficits in a viral model of multiple sclerosis.
Molecular and cellular neurosciences 2000;15(6):495-509.
2000: Dorian B McGavern; Paul D Murray; C Rivera-Quiñones; James D Schmelzer; Phillip A Low; Moses Rodriguez
Axonal loss results in spinal cord atrophy, electrophysiological abnormalities and neurological deficits following demyelination in a chronic inflammatory model of multiple sclerosis.
Brain : a journal of neurology 2000;123 Pt 3():519-31.
1999: Dorian B McGavern; Paul D Murray; Moses Rodriguez
Quantitation of spinal cord demyelination, remyelination, atrophy, and axonal loss in a model of progressive neurologic injury.
Journal of neuroscience research 1999;58(4):492-504.
1999: Dorian B McGavern; Laurie J Zoecklein; Kristen Drescher; Moses Rodriguez
Quantitative assessment of neurologic deficits in a chronic progressive murine model of CNS demyelination.
Experimental neurology 1999;158(1):171-81.
1999: M Kariuki Njenga; Paul D Murray; Dorian B McGavern; Xiaoqi Lin; Kristen Drescher; Moses Rodriguez
Absence of spontaneous central nervous system remyelination in class II-deficient mice infected with Theiler's virus.
Journal of neuropathology and experimental neurology 1999;58(1):78-91.
1998: Paul D Murray; Dorian B McGavern; Xiaoqi Lin; M Kariuki Njenga; J Leibowitz; Larry R Pease; Moses Rodriguez
Perforin-dependent neurologic injury in a viral model of multiple sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(18):7306-14.
1998: C Rivera-Quiñones; Dorian B McGavern; James D Schmelzer; SF Hunter; Phillip A Low; Moses Rodriguez
Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis.
Nature medicine 1998;4(2):187-93.
1997: Marc S Horwitz; Claire F Evans; Dorian B McGavern; M Rodriguez; Michael B A Oldstone
Primary demyelination in transgenic mice expressing interferon-gamma.
Nature medicine 1997;3(9):1037-41.