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Barbara McGrath

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Xu Xu; Sounak Gupta; Wenli Hu; Barbara C McGrath; Douglas R Cavener
Hyperthermia induces the ER stress pathway.
Douglas R Cavener; Sounak Gupta; Barbara C McGrath
PERK in beta cell biology and insulin biogenesis.
Daorong Feng; Jianwen Wei; Sounak Gupta; Barbara C McGrath; Douglas R Cavener
Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation.

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All Publications

2011: Xu Xu; Sounak Gupta; Wenli Hu; Barbara C McGrath; Douglas R Cavener
Hyperthermia induces the ER stress pathway.
PloS one 2011;6(8):e23740.
2010: Douglas R Cavener; Sounak Gupta; Barbara C McGrath
PERK in beta cell biology and insulin biogenesis.
Trends in endocrinology and metabolism: TEM 2010;21(12):714-21.
2009: Daorong Feng; Jianwen Wei; Sounak Gupta; Barbara C McGrath; Douglas R Cavener
Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation.
BMC cell biology 2009;10():61.
2007: Kaori Iida; Yulin Li; Barbara C McGrath; Ami Frank; Douglas R Cavener
PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice.
BMC cell biology 2007;8():38.
2006: Francesca Fallarino; Ursula Grohmann; Sylvaine You; Barbara C McGrath; Douglas R Cavener; Carmine Vacca; Ciriana Orabona; Roberta Bianchi; Maria Laura Belladonna; Claudia Volpi; Maria C Fioretti; Paolo Puccetti
Tryptophan catabolism generates autoimmune-preventive regulatory T cells.
Transplant immunology 2006;17(1):58-60.
2006: Francesca Fallarino; Ursula Grohmann; Sylvaine You; Barbara C McGrath; Douglas R Cavener; Carmine Vacca; Ciriana Orabona; Roberta Bianchi; Maria Laura Belladonna; Claudia Volpi; Pere Santamaria; Maria C Fioretti; Paolo Puccetti
The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):6752-61.
2006: Shun-Hsin Liang; Wei Zhang; Barbara C McGrath; Peichuan Zhang; Douglas R Cavener
PERK (eIF2alpha kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis.
The Biochemical journal 2006;393(Pt 1):201-9.
2005: Cheri R Owen; Rita Kumar; Peichuan Zhang; Barbara C McGrath; Douglas R Cavener; Gary S Krause
PERK is responsible for the increased phosphorylation of eIF2alpha and the severe inhibition of protein synthesis after transient global brain ischemia.
Journal of neurochemistry 2005;94(5):1235-42.
2005: Shuzhen Hao; James W Sharp; Catherine M Ross-Inta; Brent J McDaniel; Tracy G Anthony; Ronald C Wek; Douglas R Cavener; Barbara C McGrath; John B Rudell; Thomas J Koehnle; Dorothy W Gietzen
Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.
Science (New York, N.Y.) 2005;307(5716):1776-8.
2004: Tracy G Anthony; Brent J McDaniel; Rachel L Byerley; Barbara C McGrath; Douglas R Cavener; Margaret A McNurlan; Ronald C Wek
Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.
The Journal of biological chemistry 2004;279(35):36553-61.
2004: Hao-Yuan Jiang; Sheree A Wek; Barbara C McGrath; Dan Lu; Tsonwin Hai; Heather P Harding; Xiaozhong Wang; David Ron; Douglas R Cavener; Ronald C Wek
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response.
Molecular and cellular biology 2004;24(3):1365-77.
2003: Hao-Yuan Jiang; Sheree A Wek; Barbara C McGrath; Donalyn Scheuner; Randal J Kaufman; Douglas R Cavener; Ronald C Wek
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses.
Molecular and cellular biology 2003;23(16):5651-63.
2002: Peichuan Zhang; Barbara C McGrath; Jamie Reinert; Deanne S Olsen; Li Lei; Sangeeta Gill; Sheree A Wek; Krishna M Vattem; Ronald C Wek; Scot R Kimball; Leonard S Jefferson; Douglas R Cavener
The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.
Molecular and cellular biology 2002;22(19):6681-8.