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Christopher McGuigan
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69
Balzarini, Jan
50
De Clercq, Erik
35
Andrei, Graciela
34
Snoeck, Robert
12
Brancale, Andrea
11
Carangio, Antonella
8
Ballatore, C
8
Srinivasan, Sheila
8
Naesens, Lieve
7
Daverio, Felice
7
Heard, Charles
6
Blewett, Sally
6
Barucki, Hubert
6
Luoni, Giovanna
6
Sienaert, Rebecca
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All Publications
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2009: McGuigan Christopher; Derudas Marco; Quintiliani Maurizio; Andrei Graciela; Snoeck Robert; Henson Geoffrey; Balzarini Jan
2'-Fluorosugar analogues of the highly potent anti-varicella-zoster virus bicyclic nucleoside analogue (BCNA) Cf 1743.
Bioorganic & medicinal chemistry letters 2009;19(22):6264-7.
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2009: Mehellou Youcef; Balzarini Jan; McGuigan Christopher
Aryloxy phosphoramidate triesters: a technology for delivering monophosphorylated nucleosides and sugars into cells.
ChemMedChem 2009;4(11):1779-91.
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2009: McGuigan Christopher; Balzarini Jan
FV100 as a new approach for the possible treatment of varicella-zoster virus infection.
The Journal of antimicrobial chemotherapy 2009;64(4):671-3.
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2009: Derudas Marco; Carta Davide; Brancale Andrea; Vanpouille Christophe; Lisco Andrea; Margolis Leonid; Balzarini Jan; McGuigan Christopher
The application of phosphoramidate protide technology to acyclovir confers anti-HIV inhibition.
Journal of medicinal chemistry 2009;52(17):5520-30.
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2009: McGuigan Christopher; Perrone Plinio; Madela Karolina; Neyts Johan
The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.
Bioorganic & medicinal chemistry letters 2009;19(15):4316-20.
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2009: McGuigan Christopher; Kelleher Mary Rose; Perrone Plinio; Mulready Sinead; Luoni Giovanna; Daverio Felice; Rajyaguru Sonal; Le Pogam Sophie; Najera Isabel; Martin Joseph A; Klumpp Klaus; Smith David B
The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4'-azidocytidine (R1479).
Bioorganic & medicinal chemistry letters 2009;19(15):4250-4.
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2009: Mehellou Youcef; Balzarini Jan; McGuigan Christopher
An investigation into the anti-HIV activity of 2',3'-didehydro-2',3'-dideoxyuridine (d4U) and 2',3'-dideoxyuridine (ddU) phosphoramidate 'ProTide' derivatives.
Organic & biomolecular chemistry 2009;7(12):2548-53.
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2009: McGuigan Christopher; Daverio Felice; Nájera Isabel; Martin Joseph A; Klumpp Klaus; Smith David B
The application of the phosphoramidate ProTide approach confers micromolar potency against hepatitis C virus on inactive agent 4'-azidoinosine: kinase bypass on a dual base/sugar modified nucleoside.
Bioorganic & medicinal chemistry letters 2009;19(11):3122-4.
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2009: McGuigan Christopher; Bidet Olivier; Derudas Marco; Andrei Graciela; Snoeck Robert; Balzarini Jan
Alkenyl substituted bicyclic nucleoside analogues retain nanomolar potency against Varicella Zoster Virus.
Bioorganic & medicinal chemistry 2009;17(8):3025-7.
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2008: McGuigan Christopher; Derudas Marco; Bugert Joachim J; Andrei Graciela; Snoeck Robert; Balzarini Jan
Successful kinase bypass with new acyclovir phosphoramidate prodrugs.
Bioorganic & medicinal chemistry letters 2008;18(15):4364-7.
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2007: McGuigan Christopher; Pathirana Ranjith N; Migliore Marco; Adak Rina; Luoni Giovanna; Jones Arwyn T; Díez-Torrubia Alberto; Camarasa Maria-Jose; Velázquez Sonsoles; Henson Geoffrey; Verbeken Erik; Sienaert Rebecca; Naesens Lieve; Snoeck Robert; Andrei Graciela; Balzarini Jan
Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus.
The Journal of antimicrobial chemotherapy 2007;60(6):1316-30.
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2007: Perrone Plinio; Daverio Felice; Valente Rocco; Rajyaguru Sonal; Martin Joseph A; Lévêque Vincent; Le Pogam Sophie; Najera Isabel; Klumpp Klaus; Smith David B; McGuigan Christopher
First example of phosphoramidate approach applied to a 4'-substituted purine nucleoside (4'-azidoadenosine): conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus.
Journal of medicinal chemistry 2007;50(22):5463-70.
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2007: Mehellou Youcef; McGuigan Christopher; Brancale Andrea; Balzarini Jan
Design, synthesis, and anti-HIV activity of 2',3'-didehydro-2',3'-dideoxyuridine (d4U), 2',3'-dideoxyuridine (ddU) phosphoramidate 'ProTide' derivatives.
Bioorganic & medicinal chemistry letters 2007;17(13):3666-9.
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2007: Perrone Plinio; Luoni Giovanna M; Kelleher Mary Rose; Daverio Felice; Angell Annette; Mulready Sinead; Congiatu Costantino; Rajyaguru Sonal; Martin Joseph A; Levêque Vincent; Le Pogam Sophie; Najera Isabel; Klumpp Klaus; Smith David B; McGuigan Christopher
Application of the phosphoramidate ProTide approach to 4'-azidouridine confers sub-micromolar potency versus hepatitis C virus on an inactive nucleoside.
Journal of medicinal chemistry 2007;50(8):1840-9.
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2007: Congiatu C; Brancale A; McGuigan C
Molecular modelling studies on the binding of some protides to the putative human phosphoramidase Hint1.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1121-4.
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2006: McGuigan Christopher; Hassan-Abdallah Alshaimaa; Srinivasan Sheila; Wang Yikang; Siddiqui Adam; Daluge Susan M; Gudmundsson Kristjan S; Zhou Huiqiang; McLean Ed W; Peckham Jennifer P; Burnette Thimysta C; Marr Harry; Hazen Richard; Condreay Lynn D; Johnson Lance; Balzarini Jan
Application of phosphoramidate ProTide technology significantly improves antiviral potency of carbocyclic adenosine derivatives.
Journal of medicinal chemistry 2006;49(24):7215-26.
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2006: McGuigan Christopher; Balzarini Jan
Aryl furano pyrimidines: the most potent and selective anti-VZV agents reported to date.
Antiviral research 2006;71(2-3):149-53.
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2006: Congiatu Costantino; Brancale Andrea; Mason Malcolm D; Jiang Wen G; McGuigan Christopher
Novel potential anticancer naphthyl phosphoramidates of BVdU: separation of diastereoisomers and assignment of the absolute configuration of the phosphorus center.
Journal of medicinal chemistry 2006;49(2):452-5.
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2006: Abdulmajed K; McGuigan C; Heard C M
Topical delivery of retinyl ascorbate co-drug. 5. In vitro degradation studies.
Skin pharmacology and physiology 2006;19(5):248-58.
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2005: Abdulmajed K; McGuigan C; Heard C M
Topical delivery of retinyl ascorbate co-drug: 6. Determination of toxic dose and antioxidant activity in cultured human epidermal keratinocytes.
Die Pharmazie 2005;60(10):794-5.
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2005: Heard Charles M; Gallagher Simon J; Congiatu Costantino; Harwood John; Thomas Christopher P; McGuigan Christopher; Nemcová Marta; Nouskova Tereza
Preferential pi-pi complexation between tamoxifen and borage oil/gamma linolenic acid: transcutaneous delivery and NMR spectral modulation.
International journal of pharmaceutics 2005;302(1-2):47-55.
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2005: Luoni Giovanna; McGuigan Christopher; Andrei Graciela; Snoeck Robert; De Clercq Erik; Balzarini Jan
Bicyclic nucleoside inhibitors of Varicella-Zoster virus: the effect of branching in the p-alkylphenyl side chain.
Bioorganic & medicinal chemistry letters 2005;15(16):3791-6.
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2005: Abdulmajed Kasem; McGuigan Chris; Heard Charles M
Topical delivery of retinyl ascorbate: 4. Comparative anti-oxidant activity towards DPPH.
Free radical research 2005;39(5):491-8.
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2005: McGuigan Christopher; Harris Sarah A; Daluge Susan M; Gudmundsson Kristjan S; McLean Ed W; Burnette Thimysta C; Marr Harry; Hazen Richard; Condreay Lynn D; Johnson Lance; De Clercq Erik; Balzarini Jan
Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency.
Journal of medicinal chemistry 2005;48(10):3504-15.
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2005: McGuigan Christopher; Thiery Jean-Christophe; Daverio Felice; Jiang Wen G; Davies Gaynor; Mason Malcolm
Anti-cancer ProTides: tuning the activity of BVDU phosphoramidates related to thymectacin.
Bioorganic & medicinal chemistry 2005;13(9):3219-27.
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2005: Andrei Graciela; Sienaert Rebecca; McGuigan Chris; De Clercq Erik; Balzarini Jan; Snoeck Robert
Susceptibilities of several clinical varicella-zoster virus (VZV) isolates and drug-resistant VZV strains to bicyclic furano pyrimidine nucleosides.
Antimicrobial agents and chemotherapy 2005;49(3):1081-6.
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2005: Kelleher M R; McGuigan C; Bidet O; Carangio A; Weldon H; Andrei G; Snoeck R; De Clercq E; Balzarini J
The journey towards elucidating the anti-HCMV activity of alkylated bicyclic furano pyrimidines.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):643-5.
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2005: Gavazza F; Daverio F; Chaytor A T; Griffith T M; McGuigan C
Phosphoramidate derivatives of 2',5'-dideoxyadenosine as potential inhibitors of the EDHF phenomenon.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):553-5.
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2005: Congiatu C; McGuigan C; Jiang W G; Davies G; Mason M D
Naphthyl phosphoramidate derivatives of BVdU as potential anticancer agents: design, synthesis and biological evaluation.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):485-9.
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2004: Luoni Giovanna M; McGuigan Christopher; Andrei Graciela; Snoeck Robert; De Clercq Erik; Balzarini Jan
Bicyclic nucleoside inhibitors of varicella-zoster virus modified on the sugar moiety: 3' and 5' derivatives.
Antiviral chemistry & chemotherapy 2004;15(6):333-41.
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2004: Bidet Olivier; McGuigan Christopher; Snoeck Robert; Andrei Graciela; De Clercq Erik; Balzarini Jan
Non-nucleoside structures retain full anti-HCMV potency of the dideoxy furanopyrimidine family.
Antiviral chemistry & chemotherapy 2004;15(6):329-32.
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2004: Abdulmajed K; Heard C M; McGuigan C; Pugh W J
Topical delivery of retinyl ascorbate co-drug. 2. Comparative skin tissue and keratin binding studies.
Skin pharmacology and physiology 2004;17(6):274-82.
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2004: Balzarini Jan; Aquaro Stefano; Hassan-Abdallah Alshaimaa; Daluge Susan M; Perno Carlo-Federico; McGuigan Chris
Improved antiviral activity of the aryloxymethoxyalaninyl phosphoramidate (APA) prodrug of abacavir (ABC) is due to the formation of markedly increased carbovir 5'-triphosphate metabolite levels.
FEBS letters 2004;573(1-3):38-44.
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2004: Jarvis Chris A; McGuigan Chris; Heard Charles M
In vitro delivery of novel, highly potent anti-varicella zoster virus nucleoside analogues to their target site in the skin.
Pharmaceutical research 2004;21(6):914-9.
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2004: Griffith Tudor M; Chaytor Andrew T; Edwards David H; Daverio Felice; McGuigan Christopher
Enhanced inhibition of the EDHF phenomenon by a phenyl methoxyalaninyl phosphoramidate derivative of dideoxyadenosine.
British journal of pharmacology 2004;142(1):27-30.
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2004: Siccardi Dario; Gumbleton Mark; Omidi Yadollah; McGuigan Chistopher
Stereospecific chemical and enzymatic stability of phosphoramidate triester prodrugs of d4T in vitro.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;22(1):25-31.
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2004: Angell Annette; McGuigan Christopher; Garcia Sevillano Luis; Snoeck Robert; Andrei Graciela; De Clercq Erik; Balzarini Jan
Bicyclic anti-VZV nucleosides: thieno analogues bearing an alkylphenyl side chain have reduced antiviral activity.
Bioorganic & medicinal chemistry letters 2004;14(10):2397-9.
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2004: McGuigan Christopher; Pathirana Ranjith N; Snoeck Robert; Andrei Graciela; De Clercq Erik; Balzarini Jan
Discovery of a new family of inhibitors of human cytomegalovirus (HCMV) based upon lipophilic alkyl furano pyrimidine dideoxy nucleosides: action via a novel non-nucleosidic mechanism.
Journal of medicinal chemistry 2004;47(7):1847-51.
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2004: Sienaert R; Andrei G; Snoeck R; De Clercq E; McGuigan C; Balzarini J
Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase.
Biochemical and biophysical research communications 2004;315(4):877-83.
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2004: Gudmundsson Kristjan S; Wang Zhicheng; Daluge Susan M; Johnson Lance C; Hazen Richard; Condreay Lynn D; McGuigan Christopher
Phosphoramidate protides of carbocyclic 2',3'-dideoxy-2',3'-didehydro-7-deazaadenosine with potent activity against HIV and HBV.
Nucleosides, nucleotides & nucleic acids 2004;23(12):1929-37.
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2004: McGuigan Christopher; Carangio Antonella; Snoeck Robert; Andrei Graciela; De Clercq Erik; Balzarini Jan
Synthesis and antiviral evaluation of some 3'-fluoro bicyclic nucleoside analogues.
Nucleosides, nucleotides & nucleic acids 2004;23(1-2):1-5.
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2003: McGuigan Christopher; Brancale Andrea; Andrei Graciela; Snoeck Robert; De Clercq Erik; Balzarini Jan
Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity.
Bioorganic & medicinal chemistry letters 2003;13(24):4511-3.
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2003: Siccardi Dario; Kandalaft Lana E; Gumbleton Mark; McGuigan Christopher
Stereoselective and concentration-dependent polarized epithelial permeability of a series of phosphoramidate triester prodrugs of d4T: an in vitro study in Caco-2 and Madin-Darby canine kidney cell monolayers.
The Journal of pharmacology and experimental therapeutics 2003;307(3):1112-9.
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2003: Gudmundsson Kristjan S; Daluge Susan M; Johnson Lance C; Jansen Robert; Hazen Richard; Condreay Lynn D; McGuigan Christopher
Phosphoramidate protides of 2',3'-dideoxy-3'-fluoroadenosine and related nucleosides with potent activity against HIV and HBV.
Nucleosides, nucleotides & nucleic acids 2003;22(10):1953-61.
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2003: Jarvis Chris A; Heard Charles M; McGuigan Chris
Targeted dermal delivery of highly potent anti-varicella zoster virus nucleoside analogues from saturated solutions and ethanolic oil-in-water creams.
Journal of drug targeting 2003;11(7):433-41.
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2003: Sienaert R; Naesens L; Brancale A; Carangio A; Andrei G; Snoeck R; Van Kuilenburg A; De Clercq E; McGuigan C; Balzarini J
Metabolic and pharmacological characteristics of the bicyclic nucleoside analogues (BCNAs) as highly selective inhibitors of varicella-zoster virus (VZV).
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):995-7.
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2003: Carangio A; McGuigan C; Andrei G; Snoeck R; De Clercq E; Balzarini J
Bicyclic nucleoside inhibitors of varicella-zoster virus: synthesis and biological evaluation of 2',3'-dideoxy-3'-fluoro and 2'-deoxy-xylo derivatives.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):935-7.
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2003: Luoni G; McGuigan C; Andrei G; Snoeck R; De Clercq E; Balzarini J
Bicyclic nucleoside inhibitors of varicella-zoster virus: 5'-chloro and 3'-chloro derivatives.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):931-3.
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2003: Bidet O; McGuigan C; Andrei G; Snoeck R; De Clercq E; Balzarini J
Synthesis of unusual bicyclic nucleosides bearing an unsaturated side-chain, as potential inhibitors of varicella-zoster virus (VZV).
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):817-9.
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2003: McGuigan Christopher; Jukes Alison; Blewett Sally; Barucki Hubert; Erichsen Jonathan T; Andrei Graciella; Snoeck Robert; De Clercq Erik; Balzarini Jan
Halophenyl furanopyrimidines as potent and selective anti-VZV agents.
Antiviral chemistry & chemotherapy 2003;14(3):165-70.
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2002: Carangio A; Srinivasan S; McGuigan C; Andrei G; Snoeck R; De Clercq E; Balzarini J
Bicyclic nucleoside inhibitors of varicella-zoster virus: effect of terminal aryl substitution in the side-chain.
Antiviral chemistry & chemotherapy 2002;13(5):263-71.
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2002: Balzarini J; McGuigan C
Chemotherapy of varicella-zoster virus by a novel class of highly specific anti-VZV bicyclic pyrimidine nucleosides.
Biochimica et biophysica acta 2002;1587(2-3):287-95.
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2002: Balzarini Jan; Sienaert Rebecca; Liekens Sandra; Van Kuilenburg André; Carangio Antonella; Esnouf Robert; De Clercq Erik; McGuigan Chris
Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase.
Molecular pharmacology 2002;61(5):1140-5.
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2002: McGuigan Christopher; Blewett Sally; Siccardi Dario; Erichsen Jonathan T; Andrei Graciela; Snoek Robert; De Clercq Erik; Balzarini Jan
Alkyloxyphenyl furano pyrimidines as potent and selective anti-VZV agents with enhanced water solubility.
Antiviral chemistry & chemotherapy 2002;13(2):91-9.
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2002: Sienaert Rebecca; Naesens Lieve; Brancale Andrea; De Clercq Erik; McGuigan Christopher; Balzarini Jan
Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase.
Molecular pharmacology 2002;61(2):249-54.
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2001: Harris S A; McGuigan C; Andrei G; Snoeck R; De Clercq E; Balzarini J
Synthesis and antiviral evaluation of phosphoramidate derivatives of (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Antiviral chemistry & chemotherapy 2001;12(5):293-300.
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2001: Brancale A; McGuigan C; Algain B; Savy P; Benhida R; Fourrey J L; Andrei G; Snoeck R; De Clercq E; Balzarini J
Bicyclic anti-VZV nucleosides: Thieno analogues retain full antiviral activity.
Bioorganic & medicinal chemistry letters 2001;11(18):2507-10.
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2001: Carangio A; McGuigan C; Andrei G; Snoeck R; De Clercq E; Balzarini J
Bicyclic nucleoside inhibitors of varicella-zoster virus (VZV): Pd-catalysed synthesis of 5-aryl derivatives and their biological evaluation.
Antiviral chemistry & chemotherapy 2001;12(3):187-97.
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2001: Srinivasan S; McGuigan C; Andrei G; Snoeck R; De Clercq E; Balzarini J
Bicyclic nucleoside inhibitors of varicella-zoster virus (VZV): effect of terminal unsaturation in the side-chain.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):763-6.
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2001: Carangio A; McGuigan C; Cahard D; Andrei G; Snoeck R; De Clercq E; Balzarini J
Synthesis and in vitro evaluation of novel anti-varicella-zoster virus (VZV) nucleosides.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):653-6.
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2001: McGuigan C; Barucki H; Carangio A; Blewett S; Srinivasan S; Andrei G; Snoeck R; De Clercq E; Balzarini J
Novel aryl substituted bicyclic furo nucleosides as extremely potent and selective anti-VZV agents.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):287-96.
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2001: Blewett S; McGuigan C; Barucki H; Andrei G; Snoeck R; De Clercq E; Balzarini J
Bicyclic furo pyrimidine nucleosides with aryloxyphenyl and halophenyl substituted side chains as potent and selective varicella-zoster virus inhibitors.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):1063-6.
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2001: Ballatore C; McGuigan C; De Clercq E; Balzarini J
Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA.
Bioorganic & medicinal chemistry letters 2001;11(8):1053-6.
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2001: McGuigan C; Brancale A; Barucki H; Srinivasan S; Jones G; Pathirana R; Carangio A; Blewett S; Luoni G; Bidet O; Jukes A; Jarvis C; Andrei G; Snoeck R; De Clercq E; Balzarini J
Furano pyrimidines as novel potent and selective anti-VZV agents.
Antiviral chemistry & chemotherapy 2001;12(2):77-89.
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2001: Srinivasan S; McGuigan C; Andrei G; Snoeck R; De Clercq E; Balzarini J
Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of terminal unsaturation in the side chain.
Bioorganic & medicinal chemistry letters 2001;11(3):391-3.
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2000: McGuigan C; Barucki H; Carangio A; Blewett S; Andrei G; Snoeck R; De Clercq E; Balzarini J; Erichsen J T
Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain.
Journal of medicinal chemistry 2000;43(26):4993-7.
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2000: Brancale A; Srinivasan S; McGuigan C; Andrei G; Snoeck R; De Clercq E; Balzarini J
Synthesis and anti-varicella-zoster virus activity of some novel bicyclic nucleoside inhibitors: effect of enhanced aqueous solubility.
Antiviral chemistry & chemotherapy 2000;11(6):383-93.
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2000: McGuigan C; Pathirana R N; Jones G; Andrei G; Snoeck R; De Clercq E; Balzarini J
Anti-varicella-zoster virus bicyclic nucleosides: replacement of furo by pyrro base reduces antiviral potency.
Antiviral chemistry & chemotherapy 2000;11(5):343-8.
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2000: Knaggs M H; McGuigan C; Harris S A; Heshmati P; Cahard D; Gilbert I H; Balzarini J
A QSAR study investigating the effect of L-alanine ester variation on the anti-HIV activity of some phosphoramidate derivatives of d4T.
Bioorganic & medicinal chemistry letters 2000;10(18):2075-8.
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2000: Brancale A; McGuigan C; Andrei G; Snoeck R; De Clercq E; Balzarini J
Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of a terminal halogen substitution in the side-chain.
Bioorganic & medicinal chemistry letters 2000;10(11):1215-7.
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2000: McGuigan C; Slater M J; Parry N R; Perry A; Harris S
Synthesis and antiviral activity of acyclovir-5'-(phenyl methoxy alaninyl) phosphate as a possible membrane-soluble nucleotide prodrug.
Bioorganic & medicinal chemistry letters 2000;10(7):645-7.
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2000: McGuigan C; Bidois L; Hiouni A; Ballatore C; De Clercq E; Balzarini J
Phosphoramidate derivatives of stavudine as inhibitors of HIV: unnatural amino acids may substitute for alanine.
Antiviral chemistry & chemotherapy 2000;11(2):111-6.
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2000: Siddiqui A; McGuigan C; Ballatore C; Srinivasan S; De Clercq E; Balzarini J
Enhancing the aqueous solubility of d4T-based phosphoramidate prodrugs.
Bioorganic & medicinal chemistry letters 2000;10(4):381-4.
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2000: Aquaro S; Wedgwood O; Yarnold C; Cahard D; Pathinara R; McGuigan C; Calio' R; de Clercq E; Balzarini J; Perno C F
Activities of masked 2',3'-dideoxynucleoside monophosphate derivatives against human immunodeficiency virus in resting macrophages.
Antimicrobial agents and chemotherapy 2000;44(1):173-7.
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1999: McGuigan C; Yarnold C J; Jones G; Velázquez S; Barucki H; Brancale A; Andrei G; Snoeck R; De Clercq E; Balzarini J
Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base.
Journal of medicinal chemistry 1999;42(22):4479-84.
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1999: Siddiqui A Q; McGuigan C; Ballatore C; Zuccotto F; Gilbert I H; De Clercq E; Balzarini J
Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR.
Journal of medicinal chemistry 1999;42(20):4122-8.
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1999: Saboulard D; Naesens L; Cahard D; Salgado A; Pathirana R; Velazquez S; McGuigan C; De Clercq E; Balzarini J
Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine.
Molecular pharmacology 1999;56(4):693-704.
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1999: Siddiqui A Q; McGuigan C; Ballatore C; Wedgwood O; De Clercq E; Balzarini J
Simple mono-derivatisation of the aryl moiety of D4A and DDA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture.
Bioorganic & medicinal chemistry letters 1999;9(17):2555-60.
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1999: Ballatore C; McGuigan C; De Clercq E; Balzarini J
An in situ pig liver esterase assay as a useful predictive tool for the likely in vitro anti viral activity of phosphoramidate pro-drugs.
Nucleosides & nucleotides 1999;18(4-5):967-9.
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1999: Siddiqui A Q; Ballatore C; McGuigan C; De Clercq E; Balzarini J
The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: A structure-activity relationship.
Journal of medicinal chemistry 1999;42(3):393-9.
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1998: McGuigan C; Cahard D; Ballatore C; Siddiqui A; De Clercq E; Balzarini J
Lactate cannot substitute for alanine in d4T-based anti-HIV nucleotide prodrugs--despite efficient esterase-mediated hydrolysis.
Bioorganic & medicinal chemistry letters 1998;8(21):2949-54.
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1998: McGuigan C; Sutton P W; Cahard D; Turner K; O'Leary G; Wang Y; Gumbleton M; De Clercq E; Balzarini J
Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T).
Antiviral chemistry & chemotherapy 1998;9(6):473-9.
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1998: McGuigan C; Perry A; Yarnold C J; Sutton P W; Lowe D; Miller W; Rahim S G; Slater M J
Synthesis and evaluation of some masked phosphate esters of the anti-herpesvirus drug 882C (netivudine) as potential antiviral agents.
Antiviral chemistry & chemotherapy 1998;9(3):233-43.
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1998: Balzarini J; Cahard D; Wedgwood O; Salgado A; Velázquez S; Yarnold C J; De Clercq E; McGuigan C; Thormar H
Marked inhibitory activity of masked aryloxy aminoacyl phosphoramidate derivatives of dideoxynucleoside analogues against visna virus infection.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1998;17(4):296-302.
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1998: McGuigan C; Tsang H W; Sutton P W; De Clercq E; Balzarini J
Synthesis and anti-HIV activity of some novel chain-extended phosphoramidate derivatives of d4T (stavudine): esterase hydrolysis as a rapid predictive test for antiviral potency.
Antiviral chemistry & chemotherapy 1998;9(2):109-15.
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1998: Naesens L; Cahard D; Salgado A; Bidois L; De Clercq E; McGuigan C; Balzarini J
Metabolism and anti-HIV activity of phosphoramidate derivatives of D4T-MP with variations in the amino acid moiety.
Advances in experimental medicine and biology 1998;431():753-7.
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1997: McGuigan C; Tsang H W; Cahard D; Turner K; Velazquez S; Salgado A; Bidois L; Naesens L; De Clercq E; Balzarini J
Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation.
Antiviral research 1997;35(3):195-204.
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1997: Balzarini J; Kruining J; Wedgwood O; Pannecouque C; Aquaro S; Perno C F; Naesens L; Witvrouw M; Heijtink R; De Clercq E; McGuigan C
Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus.
FEBS letters 1997;410(2-3):324-8.
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1996: Balzarini J; Egberink H; Hartmann K; Cahard D; Vahlenkamp T; Thormar H; De Clercq E; McGuigan C
Antiretrovirus specificity and intracellular metabolism of 2',3' -didehydro-2',3'-dideoxythymidine (stavudine) and its 5'-monophosphate triester prodrug So324.
Molecular pharmacology 1996;50(5):1207-13.
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1996: Balzarini J; Wedgwood O; Kruining J; Pelemans H; Heijtink R; De Clercq E; McGuigan C
Anti-HIV and anti-HBV activity and resistance profile of 2',3'-dideoxy-3'-thiacytidine (3TC) and its arylphosphoramidate derivative CF 1109.
Biochemical and biophysical research communications 1996;225(2):363-9.
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1996: Balzarini J; Karlsson A; Aquaro S; Perno C F; Cahard D; Naesens L; De Clercq E; McGuigan C
Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):7295-9.
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1996: McGuigan C; Cahard D; Sheeka H M; De Clercq E; Balzarini J
Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.
Journal of medicinal chemistry 1996;39(8):1748-53.
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1995: McGuigan C; Wang Y; Riley P A
Synthesis and biological evaluation of substituted phosphate triester alkyl lyso phospholipids (ALPs) as novel potential anti-neoplastic agents.
FEBS letters 1995;372(2-3):259-63.
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1995: Attard G S; McGuigan C; Mackenzie A
Phase behaviour of novel phospholipid analogues.
Chemistry and physics of lipids 1995;76(1):41-8.
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1994: McGuigan C; Wang Y; Riley P A
Synthesis and biological evaluation of phosphate triester alkyl lysophospholipids (ALPs) as novel potential anti-neoplastic agents.
Anti-cancer drug design 1994;9(6):539-48.
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1994: McGuigan C; Bellevergue P; Sheeka H; Mahmood N; Hay A J
Certain phosphoramidate derivatives of dideoxy uridine (ddU) are active against HIV and successfully by-pass thymidine kinase.
FEBS letters 1994;351(1):11-4.
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1994: McGuigan C; Davies M; Pathirana R; Mahmood N; Hay A J
Synthesis and anti-HIV activity of some novel diaryl phosphate derivatives of AZT.
Antiviral research 1994;24(1):69-77.
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1993: McGuigan C; Kinchington D; Wang M F; Nicholls S R; Nickson C; Galpin S; Jeffries D J; O'Connor T J
Nucleoside analogues previously found to be inactive against HIV may be activated by simple chemical phosphorylation.
FEBS letters 1993;322(3):249-52.
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1993: McGuigan C; Pathirana R N; Balzarini J; De Clercq E
Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT.
Journal of medicinal chemistry 1993;36(8):1048-52.
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1992: McGuigan C; Nickson C; Petrik J; Karpas A
Phosphate derivatives of AZT display enhanced selectivity of action against HIV 1 by comparison to the parent nucleoside.
FEBS letters 1992;310(2):171-4.
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1992: McGuigan C; Pathirana R N; Mahmood N; Devine K G; Hay A J
Aryl phosphate derivatives of AZT retain activity against HIV1 in cell lines which are resistant to the action of AZT.
Antiviral research 1992;17(4):311-21.
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1992: McGuigan C; Nickson C; O'Connor T J; Kinchington D
Synthesis and anti-HIV activity of some novel lactyl and glycolyl phosphate derivatives.
Antiviral research 1992;17(3):197-212.
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1991: McGuigan C; O'Connor T J; Swords B; Kinchington D
Simple phospholipids have selective anti-HIV activity.
AIDS (London, England) 1991;5(12):1536-7.
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1991: McGuigan C; Devine K G; O'Connor T J; Kinchington D
Synthesis and anti-HIV activity of some haloalkyl phosphoramidate derivatives of 3'-azido-3'-deoxythymidine (AZT): potent activity of the trichloroethyl methoxyalaninyl compound.
Antiviral research 1991;15(3):255-63.
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1990: Curley D; McGuigan C; Devine K G; O'Connor T J; Jeffries D J; Kinchington D
Synthesis and anti-HIV evaluation of some phosphoramidate derivatives of AZT: studies on the effect of chain elongation on biological activity.
Antiviral research 1990;14(6):345-56.
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1990: Devine K G; McGuigan C; O'Connor T J; Nicholls S R; Kinchington D
Novel phosphate derivatives of zidovudine as anti-HIV compounds.
AIDS (London, England) 1990;4(4):371-3.
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1989: McGuigan C; Shackleton J M; Tollerfield S M; Riley P A
Synthesis and evaluation of some novel phosphate and phosphinate derivatives of araA. Studies on the mechanism of action of phosphate triesters.
Nucleic acids research 1989;17(24):10171-7.
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1989: Jones B C; McGuigan C; Riley P A
Synthesis and biological evaluation of some phosphate triester derivatives of the anti-cancer drug araC.
Nucleic acids research 1989;17(18):7195-201.
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1989: McGuigan C; Tollerfield S M; Riley P A
Synthesis and biological evaluation of some phosphate triester derivatives of the anti-viral drug AraA.
Nucleic acids research 1989;17(15):6065-75.
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