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Roderick McInnes

Research Profile

Anatomy

Living Beings

Mouse

Concepts & Ideas

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

Physiology

Mutation

Procedures

Disorders

Retinal Degeneration

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Publications

TOP 3
Evgueni Ivakine; Vivek Mahadevan; Brooke A Acton; Eric Delpire; Michelle Y Huang; David Ng; Jake Ormond; Jessica C Pressey; Michael W Salter; Man Tang; Melanie A Woodin; Roderick R McInnes
Neto2 is a KCC2 interacting protein required for neuronal Cl- regulation in hippocampal neurons.
Alexa N Bramall; Inik Chang; Eduardo Diez; Pedro D'Orleans-Juste; William W Hauswirth; Laura R Pacione; Duncan J Stewart; Michael J Szego; Masashi Yanagisawa; Roderick R McInnes
Endothelin-2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration.
Man Tang; Michael W Salter; Evgueni Ivakine; Vivek Mahadevan; Roderick R McInnes
Neto2 interacts with the scaffolding protein GRIP and regulates synaptic abundance of kainate receptors.

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All Publications

2013: Evgueni Ivakine; Vivek Mahadevan; Brooke A Acton; Eric Delpire; Michelle Y Huang; David Ng; Jake Ormond; Jessica C Pressey; Michael W Salter; Man Tang; Melanie A Woodin; Roderick R McInnes
Neto2 is a KCC2 interacting protein required for neuronal Cl- regulation in hippocampal neurons.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(9):3561-6.
2013: Alexa N Bramall; Inik Chang; Eduardo Diez; Pedro D'Orleans-Juste; William W Hauswirth; Laura R Pacione; Duncan J Stewart; Michael J Szego; Masashi Yanagisawa; Roderick R McInnes
Endothelin-2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration.
PloS one 2013;8(2):e58023.
2012: Man Tang; Michael W Salter; Evgueni Ivakine; Vivek Mahadevan; Roderick R McInnes
Neto2 interacts with the scaffolding protein GRIP and regulates synaptic abundance of kainate receptors.
PloS one 2012;7(12):e51433.
2011: Man Tang; Evgueni Ivakine; Chris J McBain; David Ng; Kenneth A Pelkey; Michael W Salter; Roderick R McInnes
Neto1 is an auxiliary subunit of native synaptic kainate receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(27):10009-18.
2010: Tomoyuki Inoue; Brenda L K Coles; Kim Dorval; Rod Bremner; Yasumasa Bessho; Ryoichiro Kageyama; Shinjiro Hino; Masao Matsuoka; Cheryl M Craft; Roderick R McInnes; Francois Tremblay; Glen T Prusky; Derek van der Kooy
Maximizing functional photoreceptor differentiation from adult human retinal stem cells.
Stem cells (Dayton, Ohio) 2010;28(3):489-500.
2010: Alexa N Bramall; Alan F Wright; Samuel G Jacobson; Roderick R McInnes
The genomic, biochemical, and cellular responses of the retina in inherited photoreceptor degenerations and prospects for the treatment of these disorders.
Annual review of neuroscience 2010;33():441-72.
2009: Ted Erclik; Volker Hartenstein; Roderick R McInnes; Howard D Lipshitz
Eye evolution at high resolution: the neuron as a unit of homology.
Developmental biology 2009;332(1):70-9.
2008: Ted Erclik; Volker Hartenstein; Howard D Lipshitz; Roderick R McInnes
Conserved role of the Vsx genes supports a monophyletic origin for bilaterian visual systems.
Current biology : CB 2008;18(17):1278-87.
2007: Avril E Castagna; Jane Addis; Roderick R McInnes; Joe T R Clarke; Peter Ashby; Susan Blaser; Brian H Robinson
Late onset Leigh syndrome and ataxia due to a T to C mutation at bp 9,185 of mitochondrial DNA.
American journal of medical genetics. Part A 2007;143A(8):808-16.
2007: Shunbin Xu; Mary E Sunderland; Brenda L K Coles; Angela Kam; Tamara Holowacz; Ruth Ashery-Padan; Till Marquardt; Roderick R McInnes; Derek van der Kooy
The proliferation and expansion of retinal stem cells require functional Pax6.
Developmental biology 2007;304(2):713-21.
2006: John Frank; Erica Di Ruggiero; Roderick R McInnes; Michael Kramer; France Gagnon
Large life-course cohorts for characterizing genetic and environmental contributions: the need for more thoughtful designs.
Epidemiology (Cambridge, Mass.) 2006;17(6):595-8.
2006: John Christodoulou; Hugh J Craig; David C Walker; Linda S Weaving; Christopher E Pearson; Roderick R McInnes
Deletion hotspot in the argininosuccinate lyase gene: association with topoisomerase II and DNA polymerase alpha sites.
Human mutation 2006;27(11):1065-71.
2006: Jaroslav P Novak; Seon-Young Kim; Jun Xu; Olga Modlich; David J Volsky; David Honys; Joan L Slonczewski; Douglas A Bell; Fred R Blattner; Eduardo Blumwald; Marjan Boerma; Manuel Cosio; Zoran Gatalica; Marian Hajduch; Juan Hidalgo; Roderick R McInnes; Merrill C Miller; Milena Penkowa; Michael S Rolph; Jordan Sottosanto; René St-Arnaud; Michael J Szego; David Twell; Charles Wang
Generalization of DNA microarray dispersion properties: microarray equivalent of t-distribution.
Biology direct 2006;1():27.
2006: Brenda L K Coles; D Jonathan Horsford; Roderick R McInnes; Derek van der Kooy
Loss of retinal progenitor cells leads to an increase in the retinal stem cell population in vivo.
The European journal of neuroscience 2006;23(1):75-82.
2005: Chi Wa Cheng; Robert L Chow; Mélanie Lebel; Rui Sakuma; Helen Oi-Lam Cheung; Vijitha Thanabalasingham; Xiaoyun Zhang; Benoit G Bruneau; David G Birch; Chi-Chung Hui; Roderick R McInnes; Shuk Han Cheng
The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development.
Developmental biology 2005;287(1):48-60.
2005: Giovanna Alfano; Carmen Vitiello; Cristina Caccioppoli; Tiziana Caramico; Antonietta Carola; Michael J Szego; Roderick R McInnes; Alberto Auricchio; Sandro Banfi
Natural antisense transcripts associated with genes involved in eye development.
Human molecular genetics 2005;14(7):913-23.
2005: D Jonathan Horsford; Minh-Thanh T Nguyen; Grant C Sellar; Rashmi Kothary; Heinz Arnheiter; Roderick R McInnes
Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity.
Development (Cambridge, England) 2005;132(1):177-87.
2004: Brenda L K Coles; Brigitte Angénieux; Tomoyuki Inoue; Katia Del Rio-Tsonis; Jason R Spence; Roderick R McInnes; Yvan Arsenijevic; Derek van der Kooy
Facile isolation and the characterization of human retinal stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(44):15772-7.
2004: Alan F Wright; Samuel G Jacobson; Artur Vahe Cideciyan; Alejandro J Roman; Xinhua Shu; Dafni Vlachantoni; Roderick R McInnes; Rudolph A Riemersma
Lifespan and mitochondrial control of neurodegeneration.
Nature genetics 2004;36(11):1153-8.
2004: Samuel G Jacobson; Alexander Sumaroka; Tomas S Aleman; Artur Vahe Cideciyan; Sharon B Schwartz; Alejandro J Roman; Roderick R McInnes; Val C Sheffield; Edwin M Stone; Anand Swaroop; Alan F Wright
Nuclear receptor NR2E3 gene mutations distort human retinal laminar architecture and cause an unusual degeneration.
Human molecular genetics 2004;13(17):1893-902.
2004: Robert L Chow; Bela Volgyi; Rachel K Szilard; David Ng; Colin McKerlie; Stewart A Bloomfield; David G Birch; Roderick R McInnes
Control of late off-center cone bipolar cell differentiation and visual signaling by the homeobox gene Vsx1.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(6):1754-9.
2003: Laura R Pacione; Michael J Szego; Sakae Ikeda; Patsy M Nishina; Roderick R McInnes
Progress toward understanding the genetic and biochemical mechanisms of inherited photoreceptor degenerations.
Annual review of neuroscience 2003;26():657-700.
2002: Elise Héon; Alex Greenberg; Kelly K Kopp; David S Rootman; Andrea L Vincent; Gail Billingsley; Megan Priston; Kimberley M Dorval; Robert L Chow; Roderick R McInnes; Godfrey Heathcote; Carol A Westall; John E Sutphin; Elena V Semina; Rod Bremner; Edwin M Stone
VSX1: a gene for posterior polymorphous dystrophy and keratoconus.
Human molecular genetics 2002;11(9):1029-36.
2001: Robert L Chow; B Snow; J Novak; J Looser; Carol L Freund-Taylor; D Vidgen; LA Ploder; Roderick R McInnes
Vsx1, a rapidly evolving paired-like homeobox gene expressed in cone bipolar cells.
Mechanisms of development 2001;109(2):315-22.
2001: Geoff Clarke; Charles J Lumsden; Roderick R McInnes
Inherited neurodegenerative diseases: the one-hit model of neurodegeneration.
Human molecular genetics 2001;10(20):2269-75.
2001: Wojciech Kedzierski; Steven Nusinowitz; David Birch; Geoff Clarke; Roderick R McInnes; Dean Bok; Gabriel H Travis
Deficiency of rds/peripherin causes photoreceptor death in mouse models of digenic and dominant retinitis pigmentosa.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(14):7718-23.
2000: E Ferda Percin; LA Ploder; J J Yu; K Arici; D Jonathan Horsford; A Rutherford; B Bapat; Diane W Cox; AM Duncan; V I Kalnins; A Kocak-Altintas; Jane C Sowden; E Traboulsi; M Sarfarazi; Roderick R McInnes
Human microphthalmia associated with mutations in the retinal homeobox gene CHX10.
Nature genetics 2000;25(4):397-401.
2000: Geoff Clarke; R A Collins; Blair R Leavitt; D F Andrews; Michael R Hayden; Charles J Lumsden; Roderick R McInnes
A one-hit model of cell death in inherited neuronal degenerations.
Nature 2000;406(6792):195-9.
2000: Geoff Clarke; Elise Héon; Roderick R McInnes
Recent advances in the molecular basis of inherited photoreceptor degeneration.
Clinical genetics 2000;57(5):313-29.
2000: Geoff Clarke; Andrew F X Goldberg; D Vidgen; L Collins; LA Ploder; L Schwarz; Laurie L Molday; Janet Rossant; Ágoston Szél; Robert S Molday; David G Birch; Roderick R McInnes
Rom-1 is required for rod photoreceptor viability and the regulation of disk morphogenesis.
Nature genetics 2000;25(1):67-73.
2000: Vincent Tropepe; Brenda L K Coles; BJ Chiasson; D Jonathan Horsford; Andrew Elia; Roderick R McInnes; Derek van der Kooy
Retinal stem cells in the adult mammalian eye.
Science (New York, N.Y.) 2000;287(5460):2032-6.
1999: S Xu; R Ladak; DA Swanson; A Soltyk; H Sun; LA Ploder; D Vidgen; A M Duncan; E Garami; David Valle; Roderick R McInnes
PHR1 encodes an abundant, pleckstrin homology domain-containing integral membrane protein in the photoreceptor outer segments.
The Journal of biological chemistry 1999;274(50):35676-85.
1998: Samuel G Jacobson; Artur Vahe Cideciyan; Y Huang; D B Hanna; Carol L Freund-Taylor; Louisa M Affatigato; R E Carr; Donald J Zack; Edwin M Stone; Roderick R McInnes
Retinal degenerations with truncation mutations in the cone-rod homeobox (CRX) gene.
Investigative ophthalmology & visual science 1998;39(12):2417-26.
1998: Melanie M Sohocki; Lori S Sullivan; HA Mintz-Hittner; David Birch; John R Heckenlively; Carol L Freund-Taylor; Roderick R McInnes; Stephen P Daiger
A range of clinical phenotypes associated with mutations in CRX, a photoreceptor transcription-factor gene.
American journal of human genetics 1998;63(5):1307-15.
1998: SJ Tang; T C Suen; Roderick R McInnes; Manuel Buchwald
Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins.
The Journal of biological chemistry 1998;273(39):25356-63.
1998: SJ Tang; PA Hoodless; Z Lu; M L Breitman; Roderick R McInnes; Jeffrey L Wrana; Manuel Buchwald
The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development.
Development (Cambridge, England) 1998;125(10):1877-87.
1998: Carol L Freund-Taylor; Q L Wang; S Chen; B L Muskat; C D Wiles; V C Sheffield; S G Jacobson; Roderick R McInnes; Donald J Zack; E M Stone
De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis.
Nature genetics 1998;18(4):311-2.
1998: P Lynne Howell; MA Turner; John Christodoulou; David C Walker; Hugh J Craig; L R Simard; LA Ploder; Roderick R McInnes
Intragenic complementation at the argininosuccinate lyase locus: reconstruction of the active site.
Journal of inherited metabolic disease 1998;21 Suppl 1():72-85.
1997: Carol L Freund-Taylor; Cheryl Y Gregory-Evans; T Furukawa; Mary Papaioannou; J Looser; LA Ploder; James Bellingham; D Ng; Jo-Anne Herbrick; A Duncan; Stephen W Scherer; Lap-Chee Tsui; A Loutradis-Anagnostou; Samuel G Jacobson; C L Cepko; Shomi S Bhattacharya; Roderick R McInnes
Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor.
Cell 1997;91(4):543-53.
1997: MA Turner; A Simpson; Roderick R McInnes; P Lynne Howell
Human argininosuccinate lyase: a structural basis for intragenic complementation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9063-8.
1997: B E Snow; Hong-Qiang Heng; XM Shi; Y Zhou; K Du; R Taub; Lap-Chee Tsui; Roderick R McInnes
Expression analysis and chromosomal assignment of the human SFRS5/SRp40 gene.
Genomics 1997;43(2):165-70.
1997: Teri L Belecky-Adams; S Tomarev; H S Li; LA Ploder; Roderick R McInnes; Olof H Sundin; Ruben Adler
Pax-6, Prox 1, and Chx10 homeobox gene expression correlates with phenotypic fate of retinal precursor cells.
Investigative ophthalmology & visual science 1997;38(7):1293-303.
1997: DA Swanson; Carol L Freund-Taylor; J M Steel; S Xu; LA Ploder; Roderick R McInnes; David Valle
A differential hybridization scheme to identify photoreceptor-specific genes.
Genome research 1997;7(5):513-21.
1997: David C Walker; John Christodoulou; Hugh J Craig; L R Simard; LA Ploder; P Lynne Howell; Roderick R McInnes
Intragenic complementation at the human argininosuccinate lyase locus. Identification of the major complementing alleles.
The Journal of biological chemistry 1997;272(10):6777-83.
1996: DA Swanson; Carol L Freund-Taylor; LA Ploder; Roderick R McInnes; David Valle
A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders.
Human molecular genetics 1996;5(4):533-8.
1996: Margit Burmeister; J Novak; M Y Liang; S Basu; LA Ploder; Norman L Hawes; D Vidgen; F Hoover; Daniel Goldman; VI Kalnins; TH Roderick; B A Taylor; MH Hankin; Roderick R McInnes
Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation.
Nature genetics 1996;12(4):376-84.
1996: Carol L Freund-Taylor; D J Horsford; Roderick R McInnes
Transcription factor genes and the developing eye: a genetic perspective.
Human molecular genetics 1996;5 Spec No():1471-88.
1995: R A Bascom; L Liu; John R Heckenlively; E M Stone; Roderick R McInnes
Mutation analysis of the ROM1 gene in retinitis pigmentosa.
Human molecular genetics 1995;4(10):1895-902.
1994: R G Taylor; Roderick R McInnes
Site-directed mutagenesis of conserved serines in rat histidase. Identification of serine 254 as an essential active site residue.
The Journal of biological chemistry 1994;269(44):27473-7.
1994: Benjamin A Taylor; S J Phillips; R A Bascom; Roderick R McInnes
The retinal outer segment membrane protein-1 gene (Rom1) maps to the proximal end of mouse chromosome 19.
Genomics 1994;23(2):510-1.
1994: I S Liu; J D Chen; LA Ploder; D Vidgen; D van der Kooy; VI Kalnins; Roderick R McInnes
Developmental expression of a novel murine homeobox gene (Chx10): evidence for roles in determination of the neuroretina and inner nuclear layer.
Neuron 1994;13(2):377-93.
1994: MA Turner; A M Achyuthan; M S Hershfield; Roderick R McInnes; P Lynne Howell
Expression, purification, crystallization and preliminary X-ray analysis of human argininosuccinic acid lyase.
Journal of molecular biology 1994;239(2):336-8.
1994: Keqin Zheng; P S Thorner; P Marrano; R Baumal; Roderick R McInnes
Canine X chromosome-linked hereditary nephritis: a genetic model for human X-linked hereditary nephritis resulting from a single base mutation in the gene encoding the alpha 5 chain of collagen type IV.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3989-93.
1993: R A Bascom; L Liu; P Humphries; Gerald A Fishman; J C Murray; Roderick R McInnes
Polymorphisms and rare sequence variants at the ROM1 locus.
Human molecular genetics 1993;2(11):1975-7.
1993: R G Taylor; D C Walker; Roderick R McInnes
E. coli host strains significantly affect the quality of small scale plasmid DNA preparations used for sequencing.
Nucleic acids research 1993;21(7):1677-8.
1993: R A Bascom; K Schappert; Roderick R McInnes
Cloning of the human and murine ROM1 genes: genomic organization and sequence conservation.
Human molecular genetics 1993;2(4):385-91.
1993: R G Taylor; D Grieco; G A Clarke; Roderick R McInnes; B A Taylor
Identification of the mutation in murine histidinemia (his) and genetic mapping of the murine histidase locus (Hal) on chromosome 10.
Genomics 1993;16(1):231-40.
1992: R A Bascom; J García-Heras; C L Hsieh; D S Gerhard; C Jones; U Francke; H F Willard; David Ledbetter; Roderick R McInnes
Localization of the photoreceptor gene ROM1 to human chromosome 11 and mouse chromosome 19: sublocalization to human 11q13 between PGA and PYGM.
American journal of human genetics 1992;51(5):1028-35.
1992: R A Bascom; S Manara; L Collins; R S Molday; VI Kalnins; Roderick R McInnes
Cloning of the cDNA for a novel photoreceptor membrane protein (rom-1) identifies a disk rim protein family implicated in human retinopathies.
Neuron 1992;8(6):1171-84.
1992: Roderick R McInnes; R A Bascom
Retinal genetics: a nullifying effect for rhodopsin.
Nature genetics 1992;1(3):155-7.
1991: R Baumal; P Thorner; V E Valli; Roderick R McInnes; P Marrano; R Jacobs; A Binnington; A G Bloedow
Renal disease in carrier female dogs with X-linked hereditary nephritis. Implications for female patients with this disease.
The American journal of pathology 1991;139(4):751-64.
1991: G Connell; R Bascom; Laurie L Molday; D Reid; Roderick R McInnes; Robert S Molday
Photoreceptor peripherin is the normal product of the gene responsible for retinal degeneration in the rds mouse.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):723-6.
1991: R G Taylor; H L Levy; Roderick R McInnes
Histidase and histidinemia. Clinical and molecular considerations.
Molecular biology & medicine 1991;8(1):101-16.
1991: R G Taylor; J García-Heras; S J Sadler; R G Lafreniere; H F Willard; David Ledbetter; Roderick R McInnes
Localization of histidase to human chromosome region 12q22----q24.1 and mouse chromosome region 10C2----D1.
Cytogenetics and cell genetics 1991;56(3-4):178-81.
1990: D C Walker; D A McCloskey; Louise R Simard; Roderick R McInnes
Molecular analysis of human argininosuccinate lyase: mutant characterization and alternative splicing of the coding region.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9625-9.
1990: R G Taylor; M A Lambert; E Sexsmith; S J Sadler; Peter N Ray; Don J Mahuran; Roderick R McInnes
Cloning and expression of rat histidase. Homology to two bacterial histidases and four phenylalanine ammonia-lyases.
The Journal of biological chemistry 1990;265(30):18192-9.
1989: P Thorner; R Baumal; V E Valli; D Mahuran; Roderick R McInnes; P Marrano
Abnormalities in the NC1 domain of collagen type IV in GBM in canine hereditary nephritis.
Kidney international 1989;35(3):843-50.
1986: Louise R Simard; W E O'Brien; Roderick R McInnes
Argininosuccinate lyase deficiency: evidence for heterogeneous structural gene mutations by immunoblotting.
American journal of human genetics 1986;39(1):38-51.
1986: M A Lambert; Louise R Simard; Peter N Ray; Roderick R McInnes
Molecular cloning of cDNA for rat argininosuccinate lyase and its expression in rat hepatoma cell lines.
Molecular and cellular biology 1986;6(5):1722-8.